nutrients Article Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats 1, 1, 1 1 2 Yong-Hyun Park y, Jae-Joon Lee y, Hee-Kyoung Son , Bok-Hee Kim , Jaemin Byun and Jung-Heun Ha 3,* 1 Department of Food and Nutrition, Chosun University, Gwangju 61452, Korea;
[email protected] (Y.-H.P.);
[email protected] (J.-J.L.);
[email protected] (H.-K.S.);
[email protected] (B.-H.K.) 2 Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA;
[email protected] 3 Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea * Correspondence:
[email protected]; Tel.: +82-41-550-3479 These authors contributed equally to this work. y Received: 25 December 2019; Accepted: 23 January 2020; Published: 27 January 2020 Abstract: Obesity has recently risen and become a serious health concern in Korea according to the westernized diet and altered lifestyle. Hence, there is a growing interest in the supplementation of phytochemicals to find a safe and effective functional ingredient to treat obesity. Spergularia marina Griseb (SM) has traditionally been used as a natural herb against chronic diseases in Korea. In this study, we investigated the antiobesity effects of SM in vitro and in vivo. SM ethanol extract (SME) inhibited proliferation and differentiation in murine adipocytes and primary porcine pre-adipocytes in a dose-dependent manner. In the in vivo study, supplementation of SM powder (SMP) remarkably attenuated fat accumulation in HFD-induced obese rats. In addition, SMP supplementation improved lipid profiles in the serum and tissues of high-fat induced obese rats.