History of Toxicology 525 History of Toxicology
HISTORY OF TOXICOLOGY 525 HISTORY OF TOXICOLOGY A Aggrawal, Maulana Azad Medical College, and legend of poison have been linked to hunting, New Delhi, India crime, punishment, politics, romance, and, of course, ß 2005, Elsevier Ltd. All Rights Reserved. medicine and the development of antidotes. Toxicology has been known from very early times in all cultures. According to Indian mythology and tra- Introduction dition, the origin of poisons is attributed to Lord Brahma, who is one of the Holy Trinity of Indian The word ‘‘poison’’ immediately conjures up images of gods (the Hindu Holy Trinity comprises Lord cloak-and-dagger conspiracies, diabolically sneering Brahma, the creator of the universe; Lord Vishnu, poisoners, unfaithful and murderous wives, mad and the preserver; and Lord Shiva, the destroyer of the cruel kings, and greedy nieces and nephews. No other universe). It is said that after the creator of the uni- single subject has a history as full of intrigue and ro- verse was offended by a devil (asura) named Kaitabha, mance as that of poison. As is the case with every he created poison to kill him. He was, no doubt, subject, the study of the history of poisons provides successful in destroying the demon with his new weap- valuable insights. The oft-quoted maxim ‘‘those who on, but its evil spread over the whole world. So much do not study history may be condemned to repeat it,’’ so that, to minimize its bad effects, Brahma had to applies very aptly to poisons. distribute it through the vegetable, animal, and miner- What exactly is a poison? A poison can be defined al kingdom and also create its antidote.
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