List of Selected Carcinogens, Toxics, and Reactive Substances
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COMBINED LIST of Particularly Hazardous Substances
COMBINED LIST of Particularly Hazardous Substances revised 2/4/2021 IARC list 1 are Carcinogenic to humans list compiled by Hector Acuna, UCSB IARC list Group 2A Probably carcinogenic to humans IARC list Group 2B Possibly carcinogenic to humans If any of the chemicals listed below are used in your research then complete a Standard Operating Procedure (SOP) for the product as described in the Chemical Hygiene Plan. Prop 65 known to cause cancer or reproductive toxicity Material(s) not on the list does not preclude one from completing an SOP. Other extremely toxic chemicals KNOWN Carcinogens from National Toxicology Program (NTP) or other high hazards will require the development of an SOP. Red= added in 2020 or status change Reasonably Anticipated NTP EPA Haz list COMBINED LIST of Particularly Hazardous Substances CAS Source from where the material is listed. 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide Acutely Toxic Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- Acutely Toxic 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Prop 65 KNOWN Carcinogens NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) IARC list Group 2A Reasonably Anticipated NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Prop 65 1-(o-Chlorophenyl)thiourea Acutely Toxic 1,1,1,2-Tetrachloroethane IARC list Group 2B 1,1,2,2-Tetrachloroethane Prop 65 IARC list Group 2B 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) Prop 65 1,1-Dichloroethane -
Preparation of Aromatic Carbonyl Compounds
~" ' MM II II II Ml I III II II I Ml II I II J European Patent Office © Publication number: 0 178 184 B1 Office_„. europeen- desj brevets^ » © EUROPEAN PATENT SPECIFICATION © Date of publication of patent specification: 28.04.93 © Int. CI.5: C07C 45/45, C07C 49/76, C07C 51/58 © Application number: 85307320.3 @ Date of filing: 11.10.85 © Preparation of aromatic carbonyl compounds. © Priority: 11.10.84 US 659598 (73) Proprietor: RAYCHEM CORPORATION (a Dela- ware corporation) @ Date of publication of application: 300 Constitution Drive 16.04.86 Bulletin 86/16 Menlo Park, California 94025(US) © Publication of the grant of the patent: @ Inventor: Horner, Patrick James 28.04.93 Bulletin 93/17 139 Buckthorn Way Menlo Park California 94025(US) © Designated Contracting States: Inventor: Jansons, Vlktors AT BE CH DE FR GB IT LI NL SE 123 New York Avenue Los Gatos California 95030(US) References cited: Inventor: Gors, Helnrlch Carl EP-A- 0 024 286 EP-A- 0 069 598 2508 Mardell Way DE-A- 2 014 514 GB-A- 1 420 506 Mountain View California, 94043(US) GB-A- 2 103 604 US-A- 1 874 580 US-A- 3 282 989 Representative: Jay, Anthony William et al Raychem Limited Intellectual Property Law Department Faraday Road Dorcan Swindon Wiltshire (GB) 00 00 00 Note: Within nine months from the publication of the mention of the grant of the European patent, any person ® may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition CL shall be filed in a written reasoned statement. -
Chemical Hygiene Plan Manual
CHEMICAL HYGIENE PLAN AND HAZARDOUS MATERIALS SAFETY MANUAL FOR LABORATORIES This is the Chemical Hygiene Plan specific to the following areas: Laboratory name or room number(s): ___________________________________ Building: __________________________________________________________ Supervisor: _______________________________________________________ Department: _______________________________________________________ Telephone numbers 911 for Emergency and urgent consultation 48221 Police business line 46919 Fire Dept business line 46371 Radiological and Environmental Management Revisied on: Enter a revision date here. All laboratory chemical use areas must maintain a work-area specific Chemical Hygiene Plan which conforms to the requirements of the OSHA Laboraotry Standard 29 CFR 19190.1450. Purdue University laboratories may use this document as a starting point for creating their work area specific CHP. Minimally this cover page is to be edited for work area specificity (non-West Lafayette laboratories are to place their own emergency, fire, and police telephone numbers in the space above) AND appendix K must be completed. This instruction and information box should remain. This model CHP is version 2010A; updates are to be found at www.purdue.edu/rem This page intentionally blank. PURDUE CHEMICAL HYGIENE PLAN AWARENESS CERTIFICATION For CHP of: ______________________________ Professor, building, rooms The Occupational Safety and Health Administration (OSHA) requires that laboratory employees be made aware of the Chemical Hygiene Plan at their place of employment (29 CFR 1910.1450). The Purdue University Chemical Hygiene Plan and Hazardous Materials Safety Manual serves as the written Chemical Hygiene Plan (CHP) for laboratories using chemicals at Purdue University. The CHP is a regular, continuing effort, not a standby or short term activity. Departments, divisions, sections, or other work units engaged in laboratory work whose hazards are not sufficiently covered in this written manual must customize it by adding their own sections as appropriate (e.g. -
5 Phosphorus Oxychloride1 Acute Exposure Guideline Levels
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 10 Committee on Acute Exposure Guideline Levels Committee on Toxicology Board on Environmental Studies and Toxicology Division on Earth and Life Studies Copyright © National Academy of Sciences. All rights reserved. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 10 THE NATIONAL ACADEMIES PRESS 500 FIFTH STREET, NW WASHINGTON, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Insti- tute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This project was supported by Contract No. W81K04-06-D-0023 and EP-W-09-007 be- tween the National Academy of Sciences and the U.S. Department of Defense and the U.S. Environmental Protection Agency. Any opinions, findings, conclusions, or recom- mendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project. International Standard Book Number-13: 978-0-309-21987-7 International Standard Book Number-10: 0-309-21987-6 Additional copies of this report are available from The National Academies Press 500 Fifth Street, NW Box 285 Washington, DC 20055 800-624-6242 202-334-3313 (in the Washington metropolitan area) http://www.nap.edu Copyright 2011 by the National Academy of Sciences. -
Elemental Fluorine Product Information (Pdf)
Elemental Fluorine Contents 1 Introduction ............................................................................................................... 4 2.1 Technical Application of Fluorine ............................................................................. 5 2.2 Electronic Application of Fluorine ........................................................................... 7 2.3 Fluorine On-Site Plant ............................................................................................ 8 3 Specifications ............................................................................................................ 9 4 Safety ...................................................................................................................... 10 4.1 Maintenance of the F2 system .............................................................................. 12 4.2 First Aid ................................................................................................................ 13 5.1 Chemical Properties ............................................................................................. 14 5.2 Physical Data ....................................................................................................... 15 6 Toxicity .................................................................................................................... 18 7 Shipping and Transport ........................................................................................... 20 8 Environment ........................................................................................................... -
The Decomposition Kinetics of Peracetic Acid and Hydrogen Peroxide in Municipal Wastewaters
Disinfection Forum No 10, October 2015 The Decomposition Kinetics of Peracetic Acid and Hydrogen Peroxide in Municipal Wastewaters INTRODUCTION Efficient control of microbial populations in municipal wastewater using peracetic acid (PAA) requires an understanding of the PAA decomposition kinetics. This knowledge is critical to ensure the proper dosing of PAA needed to achieve an adequate concentration within the contact time of the disinfection chamber. In addition, the impact of PAA on the environment, post-discharge into the receiving water body, also is dependent upon the longevity of the PAA in the environment, before decomposing to acetic acid, oxygen and water. As a result, the decomposition kinetics of PAA may have a significant impact on aquatic and environmental toxicity. PAA is not manufactured as a pure compound. The solution exists as an equilibrium mixture of PAA, hydrogen peroxide, acetic acid, and water: ↔ + + Acetic Acid Hydrogen Peroxide Peracetic Acid Water PeroxyChem’s VigorOx® WWT II Wastewater Disinfection Technology contains 15% peracetic acid by weight and 23% hydrogen peroxide as delivered. Although hydrogen peroxide is present in the formulation, peracetic acid is considered to be the active component for disinfection1 in wastewater. There have been several published studies investigating the decomposition kinetics of PAA in different water matrices, including municipal wastewater2-7. Yuan7 states that PAA may be consumed in the following three competitive reactions: 1. Spontaneous decomposition 2 CH3CO3H à 2 CH3CO2H + O2 Eq (1) 2. Hydrolysis CH3CO3H + H2O à CH3CO2H + H2O2 Eq (2) 3. Transition metal catalyzed decomposition + CH3CO3H + M à CH3CO2H + O2 + other products Eq (3) At neutral pH’s, both peracetic acid and hydrogen peroxide can be rapidly consumed by these reactions7 (hydrogen peroxide will decompose to water and oxygen via 2H2O2 à 2H2O + O2). -
Peracetic Acid Processing
Peracetic Acid Processing Identification Chemical Name(s): CAS Number: peroxyacetic acid, ethaneperoxic acid 79-21-0 Other Names: Other Codes: per acid, periacetic acid, PAA NIOSH Registry Number: SD8750000 TRI Chemical ID: 000079210 UN/ID Number: UN3105 Summary Recommendation Synthetic / Allowed or Suggested Non-Synthetic: Prohibited: Annotation: Synthetic Allowed (consensus) Allowed only for direct food contact for use in wash water. Allowed as a (consensus) sanitizer on surfaces in contact with organic food. (consensus) From hydrogen peroxide and fermented acetic acid sources only. (Not discussed by processing reviewers--see discussion of source under Crops PAA TAP review.) Characterization Composition: C2H4O3. Peracetic acid is a mixture of acetic acid (CH3COOH) and hydrogen peroxide (H2O2) in an aqueous solution. Acetic acid is the principle component of vinegar. Hydrogen peroxide has been previously recommended by the NOSB for the National List in processing (synthetic, allowed at Austin, 1995). Properties: It is a very strong oxidizing agent and has stronger oxidation potential than chlorine or chlorine dioxide. Liquid, clear, and colorless with no foaming capability. It has a strong pungent acetic acid odor, and the pH is acid (2.8). Specific gravity is 1.114 and weighs 9.28 pounds per gallon. Stable upon transport. How Made: Peracetic acid (PAA) is produced by reacting acetic acid and hydrogen peroxide. The reaction is allowed to continue for up to ten days in order to achieve high yields of product according to the following equation. O O || || CH3-C-OH + H2O2 CH3C-O-OH + H2O acetic acid hydrogen peroxyacetic peroxide acid Due to reaction limitations, PAA generation can be up to 15% with residual levels of hydrogen peroxide (up to 25%) and acetic acid (up to 35%) with water up to 25%. -
2018 Annual Survey of Biological and Chemical Agents Regulated by Homeland Security (And Carcinogens Regulated by OSHA)
Name: Dept: Date: 2018 Annual Survey of Biological and Chemical Agents regulated by Homeland Security (and carcinogens regulated by OSHA) Due (date) All labs that do not have a current chemical inventory in Chematix MUST complete this survey. The University is required to make an annual report of all chemicals on the Chemical Facility Anti-Terrorism Standards (CFATS) lists. Additional information regarding the regulations is available on the EH&S website at http://www.safety.rochester.edu/restricted/occsafe/chemicalagent.html and https://www.selectagents.gov. 1. Please review the lists on the following pages and indicate if any are possessed by your lab. The CAS# has been added to the list for ease of searching databases. The CAS# is a Chemical Abstract Service numbering system which assigns a unique number to every chemical substance based on structure; this helps avoid confusion by use of synonyms or different naming conventions. a. If yes for possession, place an X in the applicable box and if requested, include the quantity held in your lab. b. If no, leave blank. 2. After reviewing the list, please complete the information box below (or on last page for possession), then sign, date and return to EH&S. 3. Please call Donna Douglass at 275-2402 if you have any questions. Thank you for your cooperation in collecting data required by the Department of Homeland Security! Possession: 1) Fill in applicable boxes, 2) have PI sign last page, 3) return all pages to Donna Douglass OR Non-possession: 1) Check only one box on the left, 2) sign, 3) return just this page to Donna Douglass I do not have a lab, do not work in a lab, nor do I possess any of the agents in this survey. -
Benzene MSDS
He a lt h 2 3 Fire 3 2 0 Re a c t iv it y 0 Pe rs o n a l Pro t e c t io n H Material Safety Data Sheet Benzene MSDS Section 1: Chemical Product and Company Identification Product Name: Benzene Contact Information: Catalog Codes: SLB1564, SLB3055, SLB2881 Sciencelab.com, Inc. 14025 Smith Rd. CAS#: 71-43-2 Houston, Texas 77396 RTECS: CY1400000 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 TSCA: TSCA 8(b) inventory: Benzene Order Online: ScienceLab.com CI#: Not available. CHEMTREC (24HR Emergency Telephone), call: Synonym: Benzol; Benzine 1-800-424-9300 Chemical Name: Benzene International CHEMTREC, call: 1-703-527-3887 Chemical Formula: C6-H6 For non-emergency assistance, call: 1-281-441-4400 Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight Benzene 71-43-2 100 Toxicological Data on Ingredients: Benzene: ORAL (LD50): Acute: 930 mg/kg [Rat]. 4700 mg/kg [Mouse]. DERMAL (LD50): Acute: >9400 mg/kg [Rabbit]. VAPOR (LC50): Acute: 10000 ppm 7 hours [Rat]. Section 3: Hazards Identification Potential Acute Health Effects: Very hazardous in case of eye contact (irritant), of inhalation. Hazardous in case of skin contact (irritant, permeator), of ingestion. Inflammation of the eye is characterized by redness, watering, and itching. Potential Chronic Health Effects: CARCINOGENIC EFFECTS: Classified A1 (Confirmed for human.) by ACGIH, 1 (Proven for human.) by IARC. MUTAGENIC EFFECTS: Classified POSSIBLE for human. Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female [POSSIBLE]. -
Argonne Report.Pdf
CONTENTS NOTATION ........................................................................................................................... xi ABSTRACT ........................................................................................................................... 1 1 INTRODUCTION ........................................................................................................... 5 1.1 Overview of the Emergency Response Guidebook ................................................ 5 1.2 Organization of this Report ..................................................................................... 7 2 GENERAL METHODOLOGY ....................................................................................... 9 2.1 TIH List ................................................................................................................... 10 2.1.1 Background ................................................................................................. 10 2.1.2 Changes in the TIH List for the ERG2012 ................................................. 11 2.2 Shipment and Release Scenarios ............................................................................ 11 2.2.1 Shipment Profiles ........................................................................................ 12 2.2.2 Treatment of Chemical Agents ................................................................... 14 2.3 Generics, Mixtures, and Solutions .......................................................................... 17 2.4 Analysis of Water-Reactive -
Chemical Chemical Hazard and Compatibility Information
Chemical Chemical Hazard and Compatibility Information Acetic Acid HAZARDS & STORAGE: Corrosive and combustible liquid. Serious health hazard. Reacts with oxidizing and alkali materials. Keep above freezing point (62 degrees F) to avoid rupture of carboys and glass containers.. INCOMPATIBILITIES: 2-amino-ethanol, Acetaldehyde, Acetic anhydride, Acids, Alcohol, Amines, 2-Amino-ethanol, Ammonia, Ammonium nitrate, 5-Azidotetrazole, Bases, Bromine pentafluoride, Caustics (strong), Chlorosulfonic acid, Chromic Acid, Chromium trioxide, Chlorine trifluoride, Ethylene imine, Ethylene glycol, Ethylene diamine, Hydrogen cyanide, Hydrogen peroxide, Hydrogen sulfide, Hydroxyl compounds, Ketones, Nitric Acid, Oleum, Oxidizers (strong), P(OCN)3, Perchloric acid, Permanganates, Peroxides, Phenols, Phosphorus isocyanate, Phosphorus trichloride, Potassium hydroxide, Potassium permanganate, Potassium-tert-butoxide, Sodium hydroxide, Sodium peroxide, Sulfuric acid, n-Xylene. Acetone HAZARDS & STORAGE: Store in a cool, dry, well ventilated place. INCOMPATIBILITIES: Acids, Bromine trifluoride, Bromine, Bromoform, Carbon, Chloroform, Chromium oxide, Chromium trioxide, Chromyl chloride, Dioxygen difluoride, Fluorine oxide, Hydrogen peroxide, 2-Methyl-1,2-butadiene, NaOBr, Nitric acid, Nitrosyl chloride, Nitrosyl perchlorate, Nitryl perchlorate, NOCl, Oxidizing materials, Permonosulfuric acid, Peroxomonosulfuric acid, Potassium-tert-butoxide, Sulfur dichloride, Sulfuric acid, thio-Diglycol, Thiotrithiazyl perchlorate, Trichloromelamine, 2,4,6-Trichloro-1,3,5-triazine -
Chemical Name Federal P Code CAS Registry Number Acutely
Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extremely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extremely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extremely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extremely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extremely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extremely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extremely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extremely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extremely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime.