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Quaternary Ammonium Compounds
FACT SHEET: Quaternary Ammonium Compounds Quaternary ammonium compounds, also known as “quats” or “QACs,” include a number of chemicals used as sanitizers and disinfectants, including benzalkonium chloride, benzethonium chloride, cetalkonium chloride, cetrimide, cetrimonium bromide, cetylpyridinium chloride, glycidyl trimethyl, ammonium chloride, and stearalkonium chloride.[i] In general, quats cause toxic effects through all Mutagenicity routes of exposure including inhalation, Some quats have shown to be mutagenic and to ingestion, dermal application, and irrigation of damage animal DNA and DNA in human body cavities. Exposure to diluted solutions may lymphocytes at much lower levels than are result in mild irritation, while concentrated present in cleaning chemicals.[6] solutions are corrosive, causing burns to the skin and mucous Membranes. They can produce Antimicrobial Resistance systemic toxicity and can also cause allergic Genes have been discovered that mediate reactions.[2] resistance to quats. There has been an association of some of these genes with beta lactamase genes, Asthma and Allergies raising concern for a relationship between Of particular interest with regard to use as disinfectant resistance and antibiotic resistance.[7] disinfectants in the COVID-19 pandemic, quats increase the risk for asthma and allergic Reproductive Toxicity sensitization. Evidence from occupational Mice whose cages were cleaned with QACs had exposures shows increased risk of rhinitis and very low fertility rates. [8] Exposure to a common asthma -
Set up for Heating Kcl + Kcloз
Set Up for heating KCl + KClOз Crucible with unknown mixture plus MnO₂ Extension clamp Bunsen Burner To Gas Line Set Up for heating KCl + KClOз by Ashley Kajioka is licensed under a Creative Commons Attribution 4.0 International License. Procedure: Obtain a porcelain crucible, crucible lid, and a clay triangle. Clean the crucible, removing any loose particulate matter, and check the crucible for cracks. It is not necessary to remove all debris from the crucible as most of it has been fused to the porcelain and cannot be removed. In you fume hood, set up the apparatus as shown in Figure 5. a . b. e. Figure 5: Crucible setup d. a. Ring stand b. Crucible lid c. Iron ring d. Clay triangle c. e. Crucible “Lab Instructions” by Ashley Kajioka is licensed under CC BY 4.0 Using your crucible tongs, practice the following techniques on the cool crucible: Lifting the lid from the crucible Placing the lid ajar so that the crucible is slightly open, but the lid will not fall off, as in Figure 5. Quickly, but gently, pushing the lid from its ajar position to completely cover the crucible Lifting the crucible, with its lid, from the clay triangle Carrying the crucible and lid while supporting from underneath with your wire gauze. Practicing these techniques may seem silly, but it is worth your time to do so. Would you rather repeat a trial because you dropped a crucible, shattering it into a million pieces? With your covered crucible in the clay triangle, fire the crucible for 3-5 minutes. -
FDA-2015-N-0101; and FDA-2016-N-0124
DE PARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Silver Spring MD 20993 November 18, 2020 Docket Nos. FDA-1975-N-0012; FDA-2015-N-0101; and FDA-2016-N-0124 The American Cleaning Institute Attention: James Kim, PhD Vice President, Science and Regulatory Affairs 1401 H Street, N.W. Suite 700 Washington, D.C. 20005 Re: Benzalkonium Chloride, Benzethonium Chloride, Chloroxylenol, Ethanol, and Povidone-Iodine Dear Dr. Kim: This letter responds to The American Cleaning Institute’s (ACI’s) July 14, 2020 communication regarding the deferral from final rulemaking under the over-the-counter (OTC) Drug Review on benzalkonium chloride, benzethonium chloride, chloroxylenol, ethanol, and povidone-iodine for use in nonprescription (often referred to as over-the-counter or OTC) consumer antiseptic wash, health care antiseptic, and consumer antiseptic rub drug products. In March 2016, FDA issued letters granting requests to defer three active ingredients— benzalkonium chloride, benzethonium chloride, and chloroxylenol—from inclusion in the final rulemaking for the December 2013 proposed rule for OTC consumer antiseptic washes (78 FR 76444). Similarly, in January 2017, FDA issued letters granting requests to defer six active ingredients—benzalkonium chloride, benzethonium chloride, chloroxylenol, ethanol, povidone- iodine, and isopropyl alcohol—from inclusion in the final rulemaking for the May 2015 proposed rule for OTC health care antiseptics (80 FR 25166). In October 2017, FDA issued letters granting requests to defer three active -
Metalware and Laboratory Tools 109
metalware and laboratory tools 109 Rubber vacuum tubing Natural rubber, red reference Øinner Øouter type meters per FYI: (mm) (mm) per roll roll per meter RUTT-004-002 4 10 for 4/5 hose 2 RUTT-006-002 6 16 for 8/9 hose 2 RUTT-008-002 8 16 for 9/10 hose 2 RUTT-010-002 10 22 for 12/13 hose 2 "Saving package" RUTT-004-010 4 10 for 4/5 hose 10 RUTT-006-010 6 16 for 8/9 hose 10 RUTT-008-010 8 16 for 9/10 hose 10 RUTT-010-010 10 22 for 12/13 hose 10 Silicone tubing, translucent For lab applications where liquids must be transfered. Service temperature from -60 up to +200 ºC. Certificate of biocompatibility USP Class VI. Meets FDA and BgVV positive lists. reference Øinner Øouter meters per FYI: (mm) (mm) per roll roll per meter SILT-001-005 1 3 5 SILT-002-005 2 4 5 SILT-004-005 4 8 5 SILT-006-005 6 10 5 SILT-008-005 8 12 5 SILT-010-005 10 14 5 SILT-012-005 12 16 5 SILT-014-005 14 20 5 SILT-016-005 16 20 5 "Saving package" SILT-001-025 1 3 25 SILT-002-025 2 4 25 SILT-004-025 4 8 25 SILT-006-025 6 10 25 SILT-008-025 8 12 25 SILT-010-025 10 14 25 SILT-012-025 12 16 25 SILT-014-025 14 20 25 SILT-016-025 16 20 25 PTFE tubing Excellent chemical and thermal resistance (from -200 to 260 ºC) reference Øinner Øouter meters per FYI: (mm) (mm) per roll roll per meter TEFT-002-005 2 4 5 TEFT-004-005 4 6 5 TEFT-006-005 6 8 5 TEFT-008-005 8 10 5 TEFT-010-005 10 12 5 110 metalware and laboratory tools Latex tubing Amber colour. -
Science Equipment
Block Heaters with BioCote Science Equipment Colony Counter Homogenisers ® Hotplates and Stirrers protection antimicrobial Incubators Melting Point Apparatus Stuart Mixers ® Catalogue Rotary Evaporators Rockers and Shakers Water Baths and Purification Page 1 Bibby Scientific Limited Some of the most famous names in science... As one of the largest broad based manufacturers of benchtop laboratory equipment worldwide, Bibby Scientific Ltd provides internationally recognised brands with reputations for product quality and high performance. These four famous brands are now brought together in a single package to offer an excellent level of quality, service and support. Electrothermal® are the newest addition to the Bibby Scientific portfolio and are market leaders in heating mantle design and manufacture. The extensive Electrothermal® range includes controlled, stirring, Bunsen and spill-proof mantles in various shapes and capacities. Alongside the heating mantle range, Electrothermal® offer an extensive selection of stirrers and melting point apparatus. Jenway® manufactures a wide range of analytical scientific instruments including UV/Vis spectrophotometers, flame photometers, colorimeters, portable and laboratory meters for the measurement of dissolved oxygen, pH, conductivity and specific ions. The extensive Stuart® range includes blood tube rotators, colony counters, hotplates, hybridisation ovens, rockers, shakers, stirrers and water purification systems. Techne® is a world leader in the manufacture of temperature control equipment, -
Simple Chemical Experiments Simple Chemical Experiments
SIMPLE CHEMICAL EXPERIMENTS SIMPLE CHEMICAL EXPERIMENTS By ALFRED MORGAN Illustrated by THE AUTHOR APPLETON-CENTURY-CROFTS, INC. NEW YORK COPYRIGHT, 1941, BY D. APPLETON-CENTURY COMPANY, INC All rights reserved. This book, or parts thereof, must not be reproduced in any form without permission of the publisher. PRINTED IN THE UNITED STATES OF AMERICA CONTENTS CHAPTER PAGE I. YOUR LABORATORY i II. EXPERIMENTS WITH PRECIPITATES .... 26 III. EXPERIMENTS WITH SULFUR AND SOME OF ITS COMPOUNDS 54 IV. EXPERIMENTS WITH OXYGEN AND OXYGEN COM POUNDS 73 V. EXPERIMENTS WITH GASES AND SOME OF THEIR COMPOUNDS 103 VI. CHEMICAL TESTS 123 VII. SAFE "FIREWORKS" 144 VIII. EXPERIMENTS WITH A FEW ORGANIC COMPOUNDS 156 IX. CHEMICAL TRICKS AND MAGIC 170 X. MISCELLANEOUS EXPERIMENTS 186 XI. PRACTICAL USES FOR YOUR CHEMICAL KNOWL EDGE 214 XII. THE CHEMICALS YOU WILL NEED . .231 INDEX OF CHEMICALS 259 GENERAL INDEX 263 V SIMPLE CHEMICAL EXPERIMENTS *> CHAPTER I I YOUR LABORATORY I OST of the experiments described in this book can be M performed without elaborate equipment or apparatus. | For them you will need only a few bottles, test-tubes, meas- i uring-spoons, and an alcohol lamp. Jelly glasses, mayonnaise f jars, small enameled saucepans, and thin glass tumblers can | often be substituted for the beakers, flasks, and glassware of I the professional chemist. t A few of the experiments require beakers, flasks, tubing, | funnels, filter paper, crucibles, mortar and pestle, and Bunsen I burner. The small sizes of these are not expensive. Frequently the cost of apparatus and chemicals can be shared by estab lishing a "community" laboratory which is used by two or more experimenters. -
Laboratory Glasswares
We Are The Manufacture and supplier of all kinds of Laboratory Glassware, Plastic Ware, seed and rice lab equipment other Scientific Instruments having a technical excellence of many years in trade for Educational, Scientific, Medical, Research, Industrial Laboratories & Bio-Medical Institutes. Having Skilled labour and a very personal touch of service we can provide you Consistent Quality at a very Economical Price. We are Having number of machines and a skilled labour , Supervised by 6 Technically sound supervisors. We have various departments to produce the best quality and quantity too..At Present the company has major departments to cater the various needs as given Below:- 1). Research & Development 2). Manufacturing 3). Inspection at Manufacturing end. 4). Testing & Calibration under controlled atmospheric Temperature. 5). Internal Inspection Regarding Quality & Standards. 6). Printing & Annealing 7). Packing & Dispatch. The Vision of the company is to be a leading creator of Quality Glassware in Glassware Industry by using the energy of their team and by implementing Leading Edge Technology to deliver world class solutions. We Give More Than 40% Discount On Our Catalogue (Price – List )s Volumetric / Graduated Glassware - BURETTES 1 Burettes with Pinch Cock "KANHA", Rubber tubing and glass jet. Accuracy ml as per Class `B' of I.S. 1997 : 2008, ISO 385 : 2005. 0 1 Cat. No. Capacity Sub. Div. Tolerance Minimum Price/Piece 2 3 4 ml. ml. ± ml. Qty/Pack IN US $ / INR (`) 5 1.75 $ 105.00 6 1/1 **10 0.05 0.05 6 44 45 1.60$ 95.00 1/2 25 0.1 0.1 6 46 47 1.80$ 110.00 48 1/3 50 0.1 0.1 6 49 2.10$ 130.00 50 1/4 100 0.2 0.2 6 2 Burettes with Straight Bore Glass Key Stopcock "KANHA", Accuracy as per Class 'A' of I.S. -
Laboratory Equipment Reference Sheet
Laboratory Equipment Stirring Rod: Reference Sheet: Iron Ring: Description: Glass rod. Uses: To stir combinations; To use in pouring liquids. Evaporating Dish: Description: Iron ring with a screw fastener; Several Sizes Uses: To fasten to the ring stand as a support for an apparatus Description: Porcelain dish. Buret Clamp/Test Tube Clamp: Uses: As a container for small amounts of liquids being evaporated. Glass Plate: Description: Metal clamp with a screw fastener, swivel and lock nut, adjusting screw, and a curved clamp. Uses: To hold an apparatus; May be fastened to a ring stand. Mortar and Pestle: Description: Thick glass. Uses: Many uses; Should not be heated Description: Heavy porcelain dish with a grinder. Watch Glass: Uses: To grind chemicals to a powder. Spatula: Description: Curved glass. Uses: May be used as a beaker cover; May be used in evaporating very small amounts of Description: Made of metal or porcelain. liquid. Uses: To transfer solid chemicals in weighing. Funnel: Triangular File: Description: Metal file with three cutting edges. Uses: To scratch glass or file. Rubber Connector: Description: Glass or plastic. Uses: To hold filter paper; May be used in pouring Description: Short length of tubing. Medicine Dropper: Uses: To connect parts of an apparatus. Pinch Clamp: Description: Glass tip with a rubber bulb. Uses: To transfer small amounts of liquid. Forceps: Description: Metal clamp with finger grips. Uses: To clamp a rubber connector. Test Tube Rack: Description: Metal Uses: To pick up or hold small objects. Beaker: Description: Rack; May be wood, metal, or plastic. Uses: To hold test tubes in an upright position. -
A Screening-Based Approach to Circumvent Tumor Microenvironment
JBXXXX10.1177/1087057113501081Journal of Biomolecular ScreeningSingh et al. 501081research-article2013 Original Research Journal of Biomolecular Screening 2014, Vol 19(1) 158 –167 A Screening-Based Approach to © 2013 Society for Laboratory Automation and Screening DOI: 10.1177/1087057113501081 Circumvent Tumor Microenvironment- jbx.sagepub.com Driven Intrinsic Resistance to BCR-ABL+ Inhibitors in Ph+ Acute Lymphoblastic Leukemia Harpreet Singh1,2, Anang A. Shelat3, Amandeep Singh4, Nidal Boulos1, Richard T. Williams1,2*, and R. Kiplin Guy2,3 Abstract Signaling by the BCR-ABL fusion kinase drives Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myelogenous leukemia (CML). Despite their clinical activity in many patients with CML, the BCR-ABL kinase inhibitors (BCR-ABL-KIs) imatinib, dasatinib, and nilotinib provide only transient leukemia reduction in patients with Ph+ ALL. While host-derived growth factors in the leukemia microenvironment have been invoked to explain this drug resistance, their relative contribution remains uncertain. Using genetically defined murine Ph+ ALL cells, we identified interleukin 7 (IL-7) as the dominant host factor that attenuates response to BCR-ABL-KIs. To identify potential combination drugs that could overcome this IL-7–dependent BCR-ABL-KI–resistant phenotype, we screened a small-molecule library including Food and Drug Administration–approved drugs. Among the validated hits, the well-tolerated antimalarial drug dihydroartemisinin (DHA) displayed potent activity in vitro and modest in vivo monotherapy activity against engineered murine BCR-ABL-KI–resistant Ph+ ALL. Strikingly, cotreatment with DHA and dasatinib in vivo strongly reduced primary leukemia burden and improved long-term survival in a murine model that faithfully captures the BCR-ABL-KI–resistant phenotype of human Ph+ ALL. -
Flinn Scientific 2019 Purchase Guide a Quick and Easy Checklist of Science Essentials
Flinn Scientific 2019 Purchase Guide A Quick and Easy Checklist of Science Essentials Use this Purchase Guide as a handy tool for: • Taking Inventory • Order Preparation • Budget Management • Future Planning See your Flinn Scientific Catalog/Reference Manual SCIENTIFIC or visit www.flinnsci.com for product details. It’s Easy to Order Tom Trapp from Flinn Scientific! National Account Development Consultant [email protected] www.flinnsci.com/tom-trapp/sa1001 Online 402-960-5578 (mobile) www.flinnsci.com Offering personal assistance to help meet your science curriculum, supply, and lab safety needs. Email [email protected] Quality Products, Fast Delivery, Fax and Low Prices Guaranteed 1-866-452-1436 (toll free) Mail Flinn Scientific, Inc. P.O. Box 219 Batavia, IL 60510-0219 Phone 1-800-452-1261 7:30 am to 5:00 pm CT Monday through Friday Our Guarantee Flinn Scientific, Inc. guarantees that no sale is complete unless the customer is satisfied. Every item we furnish will either conform to the catalog specification, or we will ask your permission, prior to shipment, to ship an alternative product. If you find a lower published nationally advertised catalog price for an identical item, Flinn will “meet or beat” that price. Use this purchase guide containing popular product recommendations ©2019 Flinn Scientific, Inc. All Rights Reserved. to prepare your order, take inventory, and manage your budget. 1 www.flinnsci.com Flinn Scientific 2019 Purchase Guide 1 Item Rec. Item Rec. Product / Item Name Qty 2019 Price Total Product / Item Name Qty 2019 Price Total No. Qty No. Qty Safety & Personal Protection Equipment Aspirator, Water, Polypropylene AP1203 1 $ 19.30 $ - Apron, rubberized, 27" W X 36" L AP7125 30 $ 15.00 $ - Autoclave, Electric, Portable AP1004 1 $ 865.20 $ - Apron, plastic, 30" W x 36" L AP7120 30 $ 7.25 $ - ♦ Balance, Flinn Triple Beam OB2181 $ 115.00 $ - Gloves, Butyl rubber for conc. -
OHAUS New Scout Balance Range
Catalogue OHAUS new Scout Balance Range Touchscreen Page 121 Memmert Ovens & Incubators New bollé German Made Page 140 Rush Plus Small Has Arrived Page 77 Schott-DURAN Youtility Bottles A New Age Page 6 SAVINGS Up to 70% off major brands Bacto Laboratories Feb 2018 BactoIssue Laboratories 7.5 Pty Ltd - Phone (02) 9823-9000Proudly - Email [email protected] Supplying - (prices Science excl GST) Since 1966 1 Contents A Centrifuge 145 Flask, Volumetric Glass 17 Alcohol Wipes 55 Centrifuge Tube, Glass 24 Flask, Volumetric Plastic 29 Analytical Balance 117 Centrifuge Tube, Plastic 44 Forceps 88 Aspirator Bottle, Plastic 42 Chemicals 67 Forceps, Artery 92 Autoclave Indicators 59 Clamps, Bosshead 96 Fridge Thermometers 102 Autoclave Tape 59 Clamps, Burettes 97 Funnel, Glass 15 Autoclave Waste Bags 61 Clamps, Retort 96 Funnel, Plastic 30 Clinical Centrifuge 145 G - H B Coats, Laboratory 74 Gloves, Examination 72 Bacticinerator 82 Cold Bricks 69 Gloves, Safety 71 Bags, Waste 61 Colony Counter 81 Gowns 75 Balance, Moisture 119 Conductivity Meter 109 Hand Wash, Alcohol 55 Balances 116 Conical Measure, Plastic 27 Hand Wash, Cleanser 56 Batteries 102 Contaminated Waste Bags 62 Hand Wash, Sanitiser 55 Beaker, Glass 11 Coplin Jar 53 Hockey Stick 50 Beaker, Plastic 27 Corrosive Cabinets 85 Hotplate 124 Bench Roll 58 Cover Slips, Glass 52 Hotplate Stirrer 124 Biju McCartney Bottle 25 Cryo Vial, Plastic 37 Hygrometers 102 Bins, Broken Glass 61 Culture Media 50 I Bins, Chemotherapy 65 Culture Tube, Glass 24 Incubator 138 Bins, Contaminated Waste 61 Cuvettes, -
Laboratory Supplies and Equipment
Laboratory Supplies and Equipment Beakers: 9 - 12 • Beakers with Handles • Printed Square Ratio Beakers • Griffin Style Molded Beakers • Tapered PP, PMP & PTFE Beakers • Heatable PTFE Beakers Bottles: 17 - 32 • Plastic Laboratory Bottles • Rectangular & Square Bottles Heatable PTFE Beakers Page 12 • Tamper Evident Plastic Bottles • Concertina Collapsible Bottle • Plastic Dispensing Bottles NEW Straight-Side Containers • Plastic Wash Bottles PETE with White PP Closures • PTFE Bottle Pourers Page 39 Containers: 38 - 42 • Screw Cap Plastic Jars & Containers • Snap Cap Plastic Jars & Containers • Hinged Lid Plastic Containers • Dispensing Plastic Containers • Graduated Plastic Containers • Disposable Plastic Containers Cylinders: 45 - 48 • Clear Plastic Cylinder, PMP • Translucent Plastic Cylinder, PP • Short Form Plastic Cylinder, PP • Four Liter Plastic Cylinder, PP NEW Polycarbonate Graduated Bottles with PP Closures Page 21 • Certified Plastic Cylinder, PMP • Hydrometer Jar, PP • Conical Shape Plastic Cylinder, PP Disposal Boxes: 54 - 55 • Bio-bin Waste Disposal Containers • Glass Disposal Boxes • Burn-upTM Bins • Plastic Recycling Boxes • Non-Hazardous Disposal Boxes Printed Cylinders Page 47 Drying Racks: 55 - 56 • Kartell Plastic Drying Rack, High Impact PS • Dynalon Mega-Peg Plastic Drying Rack • Azlon Epoxy Coated Drying Rack • Plastic Draining Baskets • Custom Size Drying Racks Available Burn-upTM Bins Page 54 Dynalon® Labware Table of Contents and Introduction ® Dynalon Labware, a leading wholesaler of plastic lab supplies throughout