Clinical and Translational Science Award (CTSA)

Transforming Biomedical Research To Improve the Health of Our Nation’s People

Dr. Jody Sachs NIH Roadmap Project Officer Division of Clinical Research National Center for Research Resources

[email protected] Re-engineering Clinical Research

Interdisciplinary Research Public-Private Partnerships Innovator Award Bench Bedside Practice

Building Blocks and Pathways • Molecular Libraries • Bioinformatics • Integrated Research Networks Translational • Computational Biology • Clinical Research Informatics Research • Nanomedicine • NIH Clinical Research Associates Initiatives • Clinical Outcomes

Cross-cutting: Harmonization, Training Challenges to Interdisciplinary Research

ƒ The current system of academic advancement favors the independent investigator

ƒ Most institutions house scientists in discrete departments

ƒ Interdisciplinary research teams take time to assemble and require unique resources Impetus for the CTSA Program

ƒ Catalyze change - break silos, break barriers, and break conventions

ƒ Advance the new intellectual discipline of clinical and translational science

ƒ Integrate resources and training

ƒ Identify and remove impediments to clinical and translational science Philosophy of the CTSA Consortium

Team Science

Connectivity Partnerships CTSA Philosophy

Breaking Down Collaboration Institutional Barriers Clinical and Translational Science Award (CTSA)

Background: ƒ Trans-NIH collaboration through the NIH Roadmap

ƒ First RFA released October, 2005 • reviewed in summer of 2006 for October 2006 funding

ƒ Cooperative agreement mechanism • Between awardee academic institution and NIH • Multi-faceted research program • Complex award mechanism: Combined U54, T32 and K12 • 5 year award GovernanceConsortium Governance for & Organization Cooperative Agreement

Governance Manual available at http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf Building a National CTSA Consortium Building a National CTSA Consortium FY06 Grantees FY07 Grantees FY08 Grantees The Rockefeller University Emory University (partnering with Albert Einstein College of Medicine Morehouse College) University of Texas Health Sciences Boston University Medical Campus Case Western University Center at Houston Harvard University Washington University Indiana University-Purdue University at University of California, Davis Weill Cornell Medical College Indianapolis (partnering with Hunter College) University of Pittsburgh Northwestern University University Of Wisconsin Madison University of California, San Francisco Ohio State University Johns Hopkins University of Rochester School of Scripps Research Institute Medicine and Dentistry University Of Washington Stanford University Duke University University Of Michigan At Ann Arbor Tufts University Boston University of Pennsylvania University of Texas Southwestern University of Alabama at Birmingham Medical Center – Dallas Columbia University University of Colorado Denver/HSC University Of Chicago Aurora Mayo Clinic University of North Carolina Chapel Hill University Of Iowa Oregon Health and Science University University of Texas Health Science (partnering with Kaiser Permanente) Vanderbilt University (partnering with Center San Antonio Meharry Medical College) Yale University University of Utah Building a National CTSA Consortium Building a National CTSA Consortium

WA

ME MT ND VT OR MN NH ID WI NY SD MI MA WY RI CT IA PA NJ NV NE OH IN DE UT IL CO WV MD VA CA KS MO KY NC TN AZ OK AR SC NM

MS AL GA TX AK LA FL

HI Participating Institutions New members 2008 Members 2006 & 2007 Atlanta Clinical and Translational Science Institute (Atlanta-CTSI) at Emory University

Kaiser Permanente Yerkes National Primate CDC Georgia Research Center

Children’s Morehouse Emory Georgia Healthcare School of University Tech of Atlanta Medicine

Complex Carbohydrate Atlanta VA Georgia Research Center Georgia Bio Medical Center Research Alliance at U Georgia University of California, Davis Clinical and Translational Science Award

School of Veterinary Medicine

College of Agriculture and UC Davis Cancer Center Environmental Sciences

UC Davis Shriners Hospitals College of Engineering for Children– CTSC Northern California

College of Lawrence Livermore Biological Sciences National Laboratory

Department of Veterans California National Primate Affairs Northern California Research Center Health Care System CTSAWeb.org CTSA Committees and Groups ƒInstitutional Activities ƒNational Activities ƒMembership ƒMeeting schedules and summaries

http://www.ctsaweb.org/ CTSA — Creating Regional Networking Opportunities CTSA Creating Regional Networking Opportunities

University of Mayo Clinic Washington College of University of Wisconsin Medicine University Oregon Health & WA of Chicago Science University MT University of ME ND Rochester VT OR NH WI Yale University University of ID MN NY MA California, Davis SD MI CT Weill Cornell WY RI Medical College University University of of Iowa Columbia University California, PA NJ NV NE IA OH Rockefeller University San Francisco IN DE UT IL Albert Einstein Stanford CO WV MD College of Medicine University VA CA KS MO KY NC TN AZ OK AR SC The Scripps NM = CTSA Institutions Research Institute = East Coast Consortium AL GA MS = Midwest Consortium TX = West Coast Consortium AK LA FL

Washington University HI in St. Louis Find Clinical Research Networks CTSA Community Engagement CommitteeConsortium Governance & Organization

Priorities ƒ Leverage partnerships for funding ƒ Interact with other CTSA programs ƒ Foster new research on the dissemination and implementation of relevant clinical & population-based research ƒ Establish a registry of community- generated research ideas and needs assessment

Governance Manual available at http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf Clinical Research Network Feasibility Awards (CRNFA)

CRNFA RFP-W08-001 due on Nov 13, 2008 ƒ Funding was intended to support a new collaboration between a CTSA investigator and an ongoing Government funded clinical research network or clinical practice network.

ƒ The funds are not intended to support the development of a new network. ƒ Proposal focus in 3 areas; Translational Science Dissemination Research, Cost-Benefit/Cost- Effectiveness Research, and Community Engagement Research. CTSA Consortium Strategic Planning Oct 6-7, 2008 Defined National CTSA Consortium Goals

Goal 1: Enhancing National Clinical and Translational Research Capability • Clinical research management • Expand Research infrastructure • Phenotyping - human and preclinical models

Goal 2: Enhancing the Training and Career Development of Clinical and Translational Scientists CTSA Strategic Planning 2008 Defined National CTSA Consortium Goals

Goal 3: Enhancing Consortium-Wide Collaborations •National Resource Inventory •Data Sharing Network •Social Networking Initiative

Goal 4: Enhancing the Health of Our Communities and the Nation •National Model for Community Engagement •Inform Public Health Policy Through Research Transforming medicine and NIH health through discovery