THEORETICALLY DETECTABLE COMPOUNDS for NOVAPID (10.6 EV) Updated on 06/30/2020 NO
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Wo 2009/082437 A9
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 2 July 2009 (02.07.2009) WO 2009/082437 A9 (51) International Patent Classification: KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, C07D 207/08 (2006.01) A61K 31/402 (2006.01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, C07D 207/09 (2006.01) A61P 5/26 (2006.01) NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, C07D 498/04 (2006.01) SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: PCT/US2008/013657 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: G M M N S D S L s z τ z U G Z M 12 December 2008 (12.12.2008) z w Eurasian (A M B γ KG> M D RU> τ (25) Filing Language: English TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English M C M T N L N O P L P T R O S E S I s T R OAPI (30) Priority Data: B F ' B J ' C F ' C G ' C I' C M ' G A ' G N ' 0 G W ' M L ' M R ' 61/008,731 2 1 December 2007 (21 .12.2007) US N E ' S N ' T D ' T G ) - (71) Applicant (for all designated States except US): LIG- Declarations under Rule 4.17: AND PHARMACEUTICALS INCORPORATED [US/ — as to applicant's entitlement to apply for and be granted US]; 11085 N. -
United States Patent (19) 11) Patent Number: 5,072,065 Sun Et Al
United States Patent (19) 11) Patent Number: 5,072,065 Sun et al. 45 Date of Patent: Dec. 10, 1991 54 NHIBITING POPCORN POLYMER FORMATION WITH ALKYL HALDES FOREIGN PATENT DOCUMENTS 63-223003 9/1988 Japan. (75) inventors: Hsiang-ning Sun, Houston, Tex.; Steven J. Potlock, Baton Rouge, La. OTHER PUBLICATIONS Liu, Plugging-Up of Equipment by Self-Polymeriza (73) Assignee: Exxon Chemical Patents Inc., tion Butadiene Production and its Prevention, China Linden, N.J. Synthetic Rubber Industry, 11(5) 356-360 (1988) & English abstract. 21 Appl. No.: 647,358 Liu et al., Determination of Traces of Diethylhydrox ylamine Inhibitor in c5 Fraction by Gas Chromatogra 22 Fied: Jan. 29, 1991 phy, China Synthetic Rubber Industry, 12(6), 408-410 (1989) & English abstract. (51 Int, C. ........................... C07C 7/20; B08B 9/00 (52) U.S. C. ..................................... 585/2; 134/22.19; Primary Examiner-Curtis R. Davis 585/3,585/950 Attorney, Agent, or Firm-Linda K. Russell (58 Field of Search ............................... 585/3, 2,950; 57 ABSTRACT 34/22.19 Inhibition of popcorn polymer growth by treatment with an alkyl halide. This compound can be admixed (56) References Cited with organic material from which popcorn polymer is U.S. PATENT DOCUMENTS formed, or added to a system for the recovery, use or 4,404,413 9/1983 Heskell ................................ 585/950 storage of such organic material. 4,941,926 7/1990 Nakajima ................................ 585/5 4,956,020 9/1990 Nakajima ................................ 585/5 16 Claims, No Drawings 5,072,065 1. 2 once present in a system. Some of the seeds become NHIBITING POPCORN POLYMER FORMATION attached to the processing and handling equipment, and WITH ALKYL HALDES cannot be readily removed by mechanical means; more over, being insoluble in most common solvents, they are CONCURRENTLY FILED APPLICATIONS virtually impossible to wash out by use of such solvents. -
Aldrich Vapor
Aldrich Vapor Library Listing – 6,611 spectra This library is an ideal tool for investigator using FT-IR to analyze gas phase materials. It contains gas phase spectra collected by Aldrich using a GC-IR interface to ensure chromatographically pure samples. The Aldrich FT-IR Vapor Phase Library contains 6,611 gas phase FT-IR spectra collected by Aldrich Chemical Company using a GC interface. The library includes compound name, molecular formula, CAS (Chemical Abstract Service) registry number, Aldrich catalog number, and page number in the Aldrich Library of FT-IR Spectra, Edition 1, Volume 3, Vapor-Phase. Aldrich Vapor Index Compound Name Index Compound Name 6417 ((1- 3495 (1,2-Dibromoethyl)benzene; Styrene Ethoxycyclopropyl)oxy)trimethylsilane dibromide 2081 (+)-3-(Heptafluorobutyryl)camphor 3494 (1-Bromoethyl)benzene; 1-Phenylethyl 2080 (+)-3-(Trifluoroacetyl)camphor bromide 262 (+)-Camphene; 2,2-Dimethyl-3- 6410 (1-Hydroxyallyl)trimethylsilane methylenebicyclo[2.2.1]heptane 6605 (1-Methyl-2,4-cyclopentadien-1- 2828 (+)-Diisopropyl L-tartrate yl)manganese tricarbonyl 947 (+)-Isomenthol; [1S-(1a,2b,5b)]-2- 6250 (1-Propynyl)benzene; 1-Phenylpropyne Isopropyl-5-methylcyclohexano 2079 (1R)-(+)-3-Bromocamphor, endo- 1230 (+)-Limonene oxide, cis + trans; (+)-1,2- 2077 (1R)-(+)-Camphor; (1R)-(+)-1,7,7- Epoxy-4-isopropenyl-1- Trimethylbicyclo[2.2.1]heptan- 317 (+)-Longifolene; (1S)-8-Methylene- 976 (1R)-(+)-Fenchyl alcohol, endo- 3,3,7-trimethyltricyclo[5.4.0 2074 (1R)-(+)-Nopinone; (1R)-(+)-6,6- 949 (+)-Menthol; [1S-(1a,2b,5a)]-(+)-2- Dimethylbicyclo[3.1.1]heptan-2- -
Pre-Validation of an Acute Inhalation Toxicity Assay Using the Epiairway in Vitro Human Airway Model
Pre-Validation of an Acute Inhalation Toxicity Assay Using the EpiAirway In Vitro Human Airway Model George R. Jackson, Jr., Michelle Debatis, Anna G. Maione, Patrick J. Hayden Exposure to potentially dangerous chemicals can occur through inhalation. UNDERSTANDING HUMAN BIOLOGY IN DIMENSIONS3 2 Regulatory systems for classifying the acute inhalation toxicity of chemicals ≤ 0.05 mg/l > 0.05 ≤ 0.5 mg/l > 0.5 ≤ 2 mg/l > 2 mg/l Respirator Use Required 3 Regulatory systems for classifying the acute inhalation toxicity of chemicals 4 OECD 403/436 is the currently accepted test method for determining acute inhalation toxicity OECD Test Guidelines 403/436: In vivo rat LD50 test (dose at which 50% of the animals die) 4 hour exposure 14 Days Examination: - Death -Signs of toxicity -Necropsy should be performed (not always reported) Nose/Head only (preferred) Whole body Repeat stepwise with additional concentrations as necessary 5 Our goal is to develop & validate an in vitro test for acute inhalation toxicity UNDERSTANDING HUMAN BIOLOGY IN DIMENSIONS3 6 The EpiAirway Model EpiAirway is an in vitro 3D organotypic model of human tracheal/bronchial tissue. - Constructed from primary cells - Highly reproducible - Differentiated epithelium at the air-liquid interface - Beating cilia - Mucus secretion - Barrier function - Physiologically relevant & predictive of the human outcome Air Cilia Differentiated epithelium Microporous membrane Media 7 EpiAirwayTM acute inhalation toxicity test method Prepare 4-point dose Apply chemical to Incubate for 3 hours Examination: curve of chemical in the apical surface - Tissue viability (MTT) dH2O or corn oil Advantages of using the in vitro EpiAirway test: 1. -
Effect of Rutin on Gentamicin-Induced Ototoxicity in Rats: a Biochemical and Histopathological Examination
ORIGINAL ARTICLE ENT UPDATES 11(1):8-13 DOI: 10.5152/entupdates.2021.887158 Effect of Rutin on Gentamicin-Induced Ototoxicity in Rats: A Biochemical and Histopathological Examination Abstract Objective: Gentamicin is a broad-spectrum aminoglycoside antibiotic administered parenterally for moderate to severe gram-negative infections. Ototoxicity is an im- portant side effect that limits gentamicin use. The aim of this study is to investigate the effect of rutin on gentamicin-induced ototoxicity in rats biochemically and histo- pathologically. Methods: Distilled water was administered by oral gavage to healthy controls (HG) and cobalt administered group (GC). 50 mg/kg rutin was administered by oral gavage to rutin + gentamicin (RGG) group. After one hour, 100 mg/kg gentamicin was injected intraperitoneally (i.p) to the RGG and GC animal groups. This procedure was repeated once a day for 14 days. Results: Malondialdehyde (MDA), nuclear factor-κB(NF-κB), tumor necrosis factor alpha (TNF-α) and interleukin-1 beta(IL-1β) levels in the cochlear nerve tissue of gen- tamicin-treated animals were significantly higher compared to healthy controls and rutin + gentamicin treated rats. On the other hand, the amount of total Glutathione (tGSH) was significantly lower compared to the control and rutin group. Histopatho- logical examination revealed degenerated myelinated nerve fibers in the gentamicin group and Schwann cell nuclei were generally not seen. There was a high accumula- tion of collagen fiber in the tissue and dilated blood capillaries. In the rutin group, my- elinated nerve fibers mostly exhibited normal morphology, Schwann cell nuclei were İsmail Salcan1 evident and the vessels were normal. -
Of Grignard Reagent Formation. the Surface Nature of the Reaction
286 Ace. Chem. Res. 1990,23, 286-293 Mechanism of Grignard Reagent Formation. The Surface Nature of the Reaction H. M. WALBORSKY Dittmer Laboratory of Chemistry, Florida State University, Tallahassee, Florida 32306 Received February 23, 1990 (Revised Manuscript Received May 7, 1990) The reaction of organic halides (Br, C1, I) with mag- Scheme I nesium metal to yield what is referred to today as a Kharasch-Reinmuth Mechanism for Grignard Reagent Grignard reagent has been known since the turn of the Formation century,' The name derives from its discoverer, Nobel (1)(Mg0)AMg*)2y + RX 4 [(M~'~(MQ')~~-,('MQX)+ R.] + laureate Victor Grignard. How this reagent is formed, (Mgo)x-2(MQ')2~MgX)(MgR) that is, how a magnesium atom is inserted into a car- bon-halogen bond, is the subject of this Account. ('4 (Ms0),-*(M9')2~MgX)(MgR) + + (Mg0)x-dMg*)2y+2 + 2RMgX RX + Mg - RMgX Kharasch and Reinmuth,, persuaded by the work of late under the same conditions gave Itl = 6.2 X s-l. Another system that meets the above criterion is the Gomberg and Bachmad as well as by product analyses of many Grignard formation reactions that existed in vinyl system. The lack of reactivity of vinyl halides toward SN1reactions is well-known and is exemplified the literature prior to 1954,speculated that the reaction involved radicals and that the radical reactions might by the low solvolysis rate of 2-propenyl triflate5 in 80% involve "surface adherent radicals, at least in part". The ethanol at 25 OC, kl being 9.8 X s-l. -
Aldrich Raman
Aldrich Raman Library Listing – 14,033 spectra This library represents the most comprehensive collection of FT-Raman spectral references available. It contains many common chemicals found in the Aldrich Handbook of Fine Chemicals. To create the Aldrich Raman Condensed Phase Library, 14,033 compounds found in the Aldrich Collection of FT-IR Spectra Edition II Library were excited with an Nd:YVO4 laser (1064 nm) using laser powers between 400 - 600 mW, measured at the sample. A Thermo FT-Raman spectrometer (with a Ge detector) was used to collect the Raman spectra. The spectra were saved in Raman Shift format. Aldrich Raman Index Compound Name Index Compound Name 4803 ((1R)-(ENDO,ANTI))-(+)-3- 4246 (+)-3-ISOPROPYL-7A- BROMOCAMPHOR-8- SULFONIC METHYLTETRAHYDRO- ACID, AMMONIUM SALT PYRROLO(2,1-B)OXAZOL-5(6H)- 2207 ((1R)-ENDO)-(+)-3- ONE, BROMOCAMPHOR, 98% 12568 (+)-4-CHOLESTEN-3-ONE, 98% 4804 ((1S)-(ENDO,ANTI))-(-)-3- 3774 (+)-5,6-O-CYCLOHEXYLIDENE-L- BROMOCAMPHOR-8- SULFONIC ASCORBIC ACID, 98% ACID, AMMONIUM SALT 11632 (+)-5-BROMO-2'-DEOXYURIDINE, 2208 ((1S)-ENDO)-(-)-3- 97% BROMOCAMPHOR, 98% 11634 (+)-5-FLUORODEOXYURIDINE, 769 ((1S)-ENDO)-(-)-BORNEOL, 99% 98+% 13454 ((2S,3S)-(+)- 11633 (+)-5-IODO-2'-DEOXYURIDINE, 98% BIS(DIPHENYLPHOSPHINO)- 4228 (+)-6-AMINOPENICILLANIC ACID, BUTANE)(N3-ALLYL)PD(II) CL04, 96% 97 8167 (+)-6-METHOXY-ALPHA-METHYL- 10297 ((3- 2- NAPHTHALENEACETIC ACID, DIMETHYLAMINO)PROPYL)TRIPH 98% ENYL- PHOSPHONIUM BROMIDE, 12586 (+)-ANDROSTA-1,4-DIENE-3,17- 99% DIONE, 98% 13458 ((R)-(+)-2,2'- 963 (+)-ARABINOGALACTAN BIS(DIPHENYLPHOSPHINO)-1,1'- -
An Overview on “Stages of Anesthesia and Some Novel General Anesthetics Drug”
Rohit Jaysing Bhor. et al. /Asian Journal of Research in Chemistry and Pharmaceutical Sciences. 5(4), 2017, 132-140. Review Article ISSN: 2349 – 7106 Asian Journal of Research in Chemistry and Pharmaceutical Sciences Journal home page: www.ajrcps.com AN OVERVIEW ON “STAGES OF ANESTHESIA AND SOME NOVEL GENERAL ANESTHETICS DRUG” Rohit Jaysing Bhor *1 , Bhadange Shubhangi 1, C. J. Bhangale 1 1* Department of Pharmaceutical Chemistry, PRES’s College of Pharmacy Chincholi, Tal-Sinner, Dist-Nasik, Maharashtra, India. ABSTRACT Anesthesia is a painless performance of medical producers. There are both major and minor risks of anesthesia. Anesthesia is a state of temporary induced loss of sensation or awareness. It gives analgesia i.e. relief from pain or prevention of pain and paralysis. General anaesthesia is a medically induced state of unconsciousness. It gives loss of protective reflux. It is carried out to allow medical procedures or medical surgery. It can be classified into 3 types like Intravenous Anesthetics Drug; Miscellaneous Drug; and Inhalational anesthetic Drug. Sodium thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of anesthesia. Methohexital is an example of barbiturates derivatives. It is classified as short-acting, and has a rapid onset of action. KEYWORDS Anesthesia, Sodium thiopental, Methohexital and Propofol. Author for Correspondence: INTRODUCTON Anesthesia is a state of temporary induced loss of sensation or awareness. It gives analgesia i.e. relief 1 Rohit Jaysing Bhor, from pain or prevention of pain and paralysis . A patient under the effects of anesthetic drug is known Department of Pharmaceutical Chemistry, as anesthetized. -
The Asymmetric Synthesis of Styrene-Oxide and Its Reactions with Dialkylmagnesium Reagents and Boron Hydrides
University of New Hampshire University of New Hampshire Scholars' Repository Doctoral Dissertations Student Scholarship Summer 1971 THE ASYMMETRIC SYNTHESIS OF STYRENE-OXIDE AND ITS REACTIONS WITH DIALKYLMAGNESIUM REAGENTS AND BORON HYDRIDES RONALD LEROY ATKINS Follow this and additional works at: https://scholars.unh.edu/dissertation Recommended Citation ATKINS, RONALD LEROY, "THE ASYMMETRIC SYNTHESIS OF STYRENE-OXIDE AND ITS REACTIONS WITH DIALKYLMAGNESIUM REAGENTS AND BORON HYDRIDES" (1971). Doctoral Dissertations. 964. https://scholars.unh.edu/dissertation/964 This Dissertation is brought to you for free and open access by the Student Scholarship at University of New Hampshire Scholars' Repository. It has been accepted for inclusion in Doctoral Dissertations by an authorized administrator of University of New Hampshire Scholars' Repository. For more information, please contact [email protected]. 72-3736 ATKINS, Ronald Leroy, 1939- THE ASYMMETRIC SYNTHESIS OF STYRENE OXIDE AND ITS REACTIONS WITH DIALKYLMAGNESIUM REAGENTS AND BORON HYDRIDES. University of New Hampshire, Ph.D., 1971 Chemistry, organic University Microfilms, A XEROX Company, Ann Arbor, Michigan © 1971 Ronald LeRoy Atkina ALL RIGHTS RESERVED THE ASYMMETRIC SYNTHESIS OF STYRENE OXIDE AND ITS REACTIONS WITH DIALKYLMAGNESIUM REAGENTS AND BORON HYDRIDES by RONALD L. ATKINS B. S., The University of Wyoming, 1966 M. S., The University of Wyoming, 1968 A THESIS Submitted to the University of New Hampshire In Partial Fulfillment of The Requirements for the Degree of DOCTOR OF PHILOSOPHY Graduate School Department of Chemistry August, 1971 This thesis has been examined and approved. f b w < M & > YUffvyido— The^js Director, James D. Morrison Asspaiate Professor of Chemistry & L DJitdsh-iU. _____ Colin D. -
Methoxyethane, Physical Properties, Safety, MSDS, Enthalpy, Gas Liquid
(c) Bürkle GmbH 2021 Important Important information The tables “Chemical resistance of plastics”, “Plastics and their properties” and “Viscosity of liquids" as well as the information about chemical resistance given in the particular product descriptions have been drawn up based on information provided by various raw material manufacturers. These values are based solely on laboratory tests with raw materials. Plastic components produced from these raw materials are frequently subject to influences that cannot be recognized in laboratory tests (temperature, pressure, material stress, effects of chemicals, construction features, etc.). For this reason the values given are only to be regarded as being guidelines. In critical cases it is essential that a test is carried out first. No legal claims can be derived from this information; nor do we accept any liability for it. A knowledge of the chemical and mechanical resistance alone is not sufficient for the evaluation of the usability of a product. For example, the regulations concerning flammable liquids (explosion prevention) must also be taken into consideration. Copyright This table has been published and updated by Bürkle GmbH, D-79415 Bad Bellingen as a work of reference. This Copyright clause must not be removed. The table may be freely passed on and copied, provided that the information about the publisher is retained. Extensions, additions and translations If your own experiences with materials and media could be used to extend this table then we would be pleased to receive any additional information. Please send an E-Mail to [email protected]. We would also like to receive translations into other languages. -
United States Patent (19) 11) Patent Number: 4,585,788 Helsley Et Al
United States Patent (19) 11) Patent Number: 4,585,788 Helsley et al. 45) Date of Patent: Apr. 29, 1986 54 6,11-DIHYDRODIBENZB,EOXEPIN ACETIC ACIDS AND DERVATIVES FOREIGN PATENT DOCUMENTS 48-389 6/1972 Japan . 75 Inventors: Grover C. Helsley, Pottersville; 000425 7/1972 Japan. Arthur R. McFadden, East Brunswick, both of N.J.; David Primary Examiner-Norma S. Milestone Hoffman, North Kingstown, R.I. Attorney, Agent, or Firm-Curtis, Morris & Safford 57 ABSTRACT (73) Assignee: American Hoechst Corporation, 6,11-Dihydrodibenzb,eoxepin-acetic acids and deriva Somerville, N.J. tives having the general formula 21 Appl. No.: 459,774 1 22 Fied: Apr. 10, 1974 210 X Yn C-Z Related U.S. Application Data St. 5 k 63 Continuation-in-part of Ser. No. 394,801, Sep. 6, 1973, abandoned. (51) Int. Cl." .................. C07D 313/12; A61K 31/335 are prepared by multi-step sequences. X is C=O, CHCl, 52) U.S. C. ..................................... 514/450; 549/354 CHBr, CH2 or CHOR; Y is alkyl or alkoxy of 1 to 4 (58) Field of Search ........................ 260/333; 549/354; carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 514/450 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and Rl-Rs are hydrogen or alkyl of 1 to 4 carbon atoms. 56) References Cited These compounds and the physiologically tolerable U.S. PATENT DOCUMENTS salts thereof are useful as antiinflammatory and analge 3,702,852 11/1972 Yale et al. ........................... 260/333 sic agents. 3,714,201 1/1973 Yale et al. ........................... 260/333 3,758,528 9/1973 Malen et al. -
Pacs by Chemical Name (Mg/M3) (Pdf)
Table 4: Protective Action Criteria (PAC) Rev 25 based on applicable 60-minute AEGLs, ERPGs, or TEELs. Values are presented in mg/m3. August 2009 Table 4 is an alphabetical listing of the chemicals in the PAC data set. It provides Chemical Abstract Service Registry Numbers (CASRNs)1, PAC values, and technical information on the source of the PAC values. Table 4 presents all values for TEEL-0, PAC-1, PAC-2, and PAC-3 in mg/m3. The conversion of ppm to mg/m3 is calculated assuming 25 ºC and 760 mm Hg. The columns presented in Table 4 provide the following information: Heading Definition No. The ordered numbering of the chemicals as they appear in this alphabetical listing. Chemical Name The chemical name given to the PAC Development Team. CASRN The Chemical Abstract Service Registry Number for this chemical. TEEL-0 This is the threshold concentration below which most people will experience no adverse health effects. This PAC is always based on TEEL-0 because AEGL-0 or ERPG-0 values do not exist. PAC-1 Based on the applicable AEGL-1, ERPG-1, or TEEL-1 value. PAC-2 Based on the applicable AEGL-2, ERPG-2, or TEEL-2 value. PAC-3 Based on the applicable AEGL-3, ERPG-3, or TEEL-3 value. Source of PACs: Technical comments provided by the PAC development team that TEEL-0, PAC-1, indicate the source of the data used to derive PAC values. Future efforts PAC-2, PAC-3 are directed at reviewing, revising, and enhancing this information.