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We're Here to Help A PROSTATE CANCER TOOLKIT FOR NEWLY DIAGNOSED MEN AND FAMILIES So you’re newly diagnosed with prostate cancer... We’re here to help. A PATIENT EDUCATION SERIES ZEROCANCER.ORG We’re here to help. TABLE OF CONTENTS Page 1. Overview 3 2. Prostate Cancer Basics 4 3. How is Prostate Cancer Diagnosed? 6 4. Understanding Your Prostate Cancer 10 5. Choosing Your Health Care Team 15 6. Treatment Options 17 7. Research and Clinical Trials 21 8. Nutrition and Exercise 23 9. Additional Resources and Downloadable Tools 25 10. Glossary Prostate Cancer Terms 31 Health Care “Words that Matter” 34 11. ZERO Patient Programs 40 2 A PROSTATE CANCER TOOLKIT FOR NEWLY DIAGNOSED MEN AND FAMILIES You’ve Been Diagnosed With Prostate Cancer. Now What? A prostate cancer diagnosis can be scary and overwhelming, but finding helpful resources to aid in your fight shouldn’t be. We developed this guide for newly- diagnosed men and their families to help cut through the clutter and provide clear, easy to digest information about prostate cancer tailored for someone like you who is just beginning his journey. This toolkit focuses on the basics of your prostate cancer diagnosis, treatment options, lifestyle changes, and support resources. We’ll also share advice and words of wisdom from men who are fighting the disease or who’ve won their battles. It’s important to remain hopeful on your journey. Most prostate cancer is slow growing and more than 2.9 million American men are living with the disease today. Arm yourself with education and rally your support network. You aren’t alone in your fight: ZERO is here to help. Don’t panic. Do your research. Seek out support – whether that might be with a support group or with your family or friend – continue to do your research, as the disease doesn’t affect all men the same way. Johnny Payne, prostate cancer survivor 3 A PATIENT EDUCATION SERIES ZEROCANCER.ORG A PROSTATE CANCER TOOLKIT FOR NEWLY DIAGNOSED MEN AND FAMILIES Prostate Cancer Basics Now that you’ve been diagnosed with prostate cancer, it is very important that you arm yourself with education so that you can understand the disease you’re fighting and make the most informed decisions about your treatment options. Prostate cancer is usually a very slow growing disease and once diagnosed there is time to gather information, consider your options, and make a plan. More than 50 percent of men newly diagnosed with prostate cancer have low-risk disease that will likely not spread beyond the prostate to cause harm, problems, or symptoms. However, some prostate cancers are aggressive and will spread to other parts of the body. There are more than 2.9 million prostate cancer survivors in the U.S. today. You have cause to hope for a long, healthy life. The Basics: What is my prostate? The prostate is a walnut-shaped gland located below the bladder, behind the base of the penis, and in front of the rectum. It surrounds the upper part of the urethra, which is the tube that carries urine from the bladder. The prostate makes seminal fluid that protects, supports, and helps transport sperm. The Basics: What is prostate cancer? Normally, as cells grow old and die, new cells take their place. Prostate can- cer is a disease in which normal cells in a man’s prostate gland change and grow uncontrollably to form a tumor. Only men can develop prostate cancer because only men have a prostate gland. Prostate cancer is the most common type of cancer diagnosed in American men. Drawing of four panels showing how normal cells may become cancer cells. The first panel shows normal cells. The second and third panels show abnormal cell changes called hyperplasia and dysplasia. The fourth panel shows cancer cells. 4 A PATIENT EDUCATION SERIES ZEROCANCER.ORG A PROSTATE CANCER TOOLKIT FOR NEWLY DIAGNOSED MEN AND FAMILIES LEARN DOWNLOAD LEARN DOWNLOAD more of the basics on our About prostate cancer at Prostate Cancer zerocancer.org Fact Sheet. The Basics: Statistics and Risk Factors Now that you’ve been diagnosed with prostate cancer, you may want to familiarize yourself with some statistics and risk factors about the disease. Knowing how many men are affected and what risk factors contribute to a prostate cancer diagnosis is one way to better understand what you’re fighting. READ READ READ: READ: American Men and 10 Things Everyone Prostate Cancer By Should Know About The Numbers Prostate Cancer • One in nine American men will have prostate cancer during his lifetime. • Prostate cancer is the second leading cause of cancer death among American men and is the most commonly diagnosed. • The American Cancer Society estimates in its Cancer Facts & Figures 2018 report that 164,690 men will be told they have prostate cancer in 2018 and 29,430 will die from the disease this year. • The most recent research shows the five-year survival rate for all men with prostate cancer is nearly 100 percent. • The relative 10-year survival rate is 98 percent, and 96 percent for 15 years. • Currently there are nearly 2.9 million American men living with the disease – roughly equal to the population of Chicago. 5 A PATIENT EDUCATION SERIES ZEROCANCER.ORG A PROSTATE CANCER TOOLKIT FOR NEWLY DIAGNOSED MEN AND FAMILIES All men are at risk of developing prostate cancer. Women are not at risk because they do not have a prostate. The greatest risk factors for developing the disease are increasing age, family history, ethnicity, and diet. If any of the following describe you, you are at increased risk for prostate cancer. RISK FACTORS • I am older than 50 FAMILY • I have a family history of prostate cancer RACE HISTORY • I am African-American AGING DIET LEARN LEARN more about risk factors. GENE CHANGES CHEMICALS How is Prostate Cancer Diagnosed? If you’re reading this guide, you likely have been diagnosed with prostate cancer. Prostate cancer is diagnosed using a number of tests described below. You likely have already had some of these, but you may need further tests to find out whether the cancer has spread and how aggressive it is. You may not need to have all of these tests, and you might not have them in this order. PSA Test – The PSA Test is a blood test that measures the amount of prostate specific antigen (PSA) in your blood. PSA is a protein produced by normal cells in your prostate and also by prostate cancer cells. It’s normal to have a small amount of PSA in your blood, and the amount rises as you get older. Digital Rectal Examination (DRE) – During a Digital Rectal Examination (DRE) a doctor or nurse feels your prostate through the wall of the back passage (rectum) to check for any lumps or hard areas and to get an idea of its size. They’ll wear gloves and put some lubricant onto their finger to make it more comfortable. Prostate Biopsy – A biopsy involves using thin needles to take small pieces of tissue from the prostate. The tissue is then looked at under a microscope to check for cancer. Cancer can only be diagnosed with a tissue sample. 6 A PATIENT EDUCATION SERIES ZEROCANCER.ORG A PROSTATE CANCER TOOLKIT FOR NEWLY DIAGNOSED MEN AND FAMILIES NEW TESTING OPTIONS Recent research has yielded additional tests that can give you and your medical team more information to help determine the probability of both finding cancer during a biopsy and determining how aggressive that cancer is likely to be. 4Kscore – 4Kscore is a blood test providing patient-specific probability of finding an aggressive form of prostate cancer during a biopsy. Doctors and patients can then make an informed decision on whether to have a biopsy. The test measures total PSA, free PSA, Intact PSA, and for certain enzymes called kallikrein. An algo- rithm used with the patient’s age and physical exam gives a probability percent- age of having aggressive disease. AR-V7 – The blood-based test detects the V7 variant of the androgen receptor protein (AR-V7) in the nucleus of circulating tumor cells (CTC) — information that can help guide treatment selection in patients with metastatic castration-resistant prostate cancer. Axumin – A molecular imaging agent indicated for use in PET imaging to identify suspected sites of prostate cancer recurrence in men who have elevated blood levels of PSA following prior treatment. ConfirmMDx – The ConfirmMDx test addresses false-negative biopsy concerns to prevent undergoing unnecessary repeat biopsies and screening procedures and help reduce complications for patients. A specimen from the biopsy is required in order to benefit from this test. EPI – The EPI test is a completely non-invasive, urine-based test to help rule out high-grade prostate cancer. Know Error – The Know Error® system utilizes bar coding and forensic principles testing to confirm that surgical biopsy samples being evaluated belong exclu- sively to the patient being diagnosed and further confirm tissue specimens are free from contamination which can otherwise confound test results. PCA3 – PCA3 is a urine test that more accurately detects the possibility of prostate cancer by examining the expression of PCA3 – a gene specific to prostate cancer. The PCA3 score is used to determine the need for repeated biopsies. Research has continued for years to look into whether PCA3 can replace or serve as a substitute for the PSA test Phi – The Prostate Health Index combines three blood tests that give a more accurate “Phi Score,” which gives information based on a high PSA to better de- termine the probability of finding cancer during a biopsy.
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