AUTHOR INDEX
Abdo, Kamal M., 31 Colburn, W. A., 458 Gorodetzky, Charles W., 446 Keirns, James J., 568 Abou-Donia, Mohamed B., 31 Colby, Howard D., 67 Grant,D.M.,218 Kido, Yasumasa, 152, 190 Adline, Jacques, 574 Collins, Jerry M., 41 Greenblatt, D. J., 70 Kiechel, Jean R., 585 Alley, Earl 0., 611 Colvin, Michael E., 103 Griffeth, Landis K., 517 Kinnes, Carolyn G., 31 Al-Wathiqui, MahmOOd H., 172 Cone, Edward J., 446 GriflithS, L. A., 602 Klaassen, Curtis D., 37 Andersson, Tommy, 494 Conney, Allan H., 556 Grimley, J. M., 611 Klingensmith, J. Scott, 329 Andrews, Paul A., 167 Conradi, E. C., 344 Gruenke, Larry D., 244 Klippert, Pierre J. M., 62 Angevine, Linda S., 25 Cook, M. W., 59 Guarna, Antonio, 581 Knapp, D. R., 344 Araujo, M. E., 85 Coomes, M. W., 550 Gumbrecht, Judy Raucy., 312 Kolis,S.J., 324 Arison, B. H., 54, 147 Corpet, D. E., 249 Guyot, M., 286 Kostenbauder, Harry B., 361 Au, Wiffiam Y. W., 531 Coder, S., 458 Krause, W., 91 Aulerich, R. J., 441 Craig, John C., 244 Hackett, A. M., 602 K#{252}hne,0., 91 Crankshaw, Daune L., 477 Hadley, William M., 275 Kwan, K. C., 79 Baba, Shigeo, 387 Cresteil, Thierry, 585 Haegele, Klaus D., 195 Bachur, Nicholas R., 41, 167 Hallstr#{246}m,G#{246}sta.,15,47 La Du, Bert N., 283 Bai, S. A., 266, 394, 544 DaM, Alan R., 275 Hansen, D. K., 21 Lane, E. A., 286 Bailey, Keith, 277 Dali!, Raymond R., 411 Hansson, Tiiu, 494 Latini, Roberto, 509 Baker, Max T., 308 Dairman, W., 70 Hanzlik, Robert P., 201 La Bigot, Jean F., 585 Bargar, E. M., 266, 344 D’Ambrosio, Steven M., 158 Harigaya, S., 371 LeCh,J.J., 319 Barsuhn, Karen J., 507 Daniel, F. Bernard, 158 Hartmann, Franz, 244 Lee, Steven, 239 Lehman, Bateman, C. P., 301 Darwin, William D., 446 Hashimura, Yoshimasa, 377 James P., 221 Baughman, Robert A., Jr., 143 Dawson, Christopher A., 411 Heck, Henry d’A., 417, 421 Leibman, Kenneth C., 164, 620 Beaune, Philippe, 499, 585 Della Corte, Laura, 581 Hemberger, Judith A., 73, 615 La Provost, Evelyne, 499 Bekersky, I., 512 DePaulo, J. R., 221 Hill, Donald E., 531 Lerner, Brad D., 41 Benet, Leslie Z., 143 Dc Sarlo, Francesco, 581 Hinson, Jack A., 103 Leroux, Jean-Paul, 499 Bertilsson,L., 115 Dickinson, R. 0., 607 Hodes,M.E.,2l Levin,V.A., 175 Bickel, M. H., 597 Di Stefano, Emma W., 47 Holtzman, Jordan L., 477 Levin, W., 339 Bickers, David R., 562 Divoll, M., 70 Hooper, W. D., 607 Levine, Walter 0., 239 Birgersson,C., 115 Doull, John, 366 Homing, E. C., 463 Levy, R. H., 286 Birnbaum, L. S., 537 Duncan,C.A.H., 147 Homing, M. 0., 463 Lin, Yi-Jong, 75, 273 Bissell, D. Montgomery, 244 Duncan, J. D., 15 Houston, J. Brian, 131 Lindberg, C., 590 Bjornsson, Thorir D., 31 Duquette, Peter H., 477 Houston, T., 617 Lindeke, B., 15 Blake, J. W., 120, 226, 617 Huang, Mou-Taun, 556 Lindemann, Nancy J., 477 Bonati, M., 509 Eadie, M. J., 607 Hucker, H. B., 54 Little, Peter J., 350 Bones, 0. F., 249 Eastin, W. C., Jr., 537 Huebert, Norman D., 195 Liu, Shean-Jang, 335 Bortolotti, Angela, 509 Eastman,C.L., 109 Hugenroth, S., 463 Loiseau, P., 286 Brachet-Liermain, A., 286 Edsb#{228}cker,S., 590 Hunter, Eric, 361 Lynn,R.K., 109,293 Branfman, Alan R., 206, 211 Egorin, Merrill J., 41, 167 Hun, J. E., 54 Macgregor, Thomas R., 568 Breger, R. K., 319 Eigenberg, David A., 366 Marlowe, Carolyn, 172 Breimer, D. D., 489 Emudianughe, Towuanse S., 97 Igwe, 0. J., 120 Matthews, H. B., 537 Brendel, Klaus, 433 Estus, 0. Steven, 471 Ikebuchi, Hideharu, 152 Maya, M. R., 85 Brown, Robert A., Jr., 355, 392 Ishida, TakaShi, 190 McCall, John M., 507 Bruni, Robert J., 206 Falany, C. N., 426 McComish, Madeline F., 206, 211 Buchwald, Wiffiam F., 446 Farina, Peter R., 568 Jacobsen, N. W., 607 McNulty, Michael J., 417, 421 Bugg#{233},C. J. L., 458 Feng, Paul C. C., 103 James, Margaret 0., 350 Mehendale, Harihara M., 25, 329 Burke, Terrence R., Jr., 126 Fenselau, Catherine, 103, 221 Jeffrey, Alan M., 556 MellstrOm, B., 115 Butz, Robert F., 481 Figueira, M. A., 85 Jerina, Donald M., 1 Mico, Bruce A., 143 Findlay, John W. A., 481 Jiritano, Luisa, 509 Mieyal, John J., 471 Caidwell, John, 97 Flinois, Jean-Pierre, 499 Joeres, R. P., 489 Milam, D. F., 109, 293 Callahan, Marianne M., 206, 211 FOrlin, Lan, 494 Johnson, Garland A., 507 Miles, Philip R., 67 Carvathas, M. L., 85 Foster, P. M. D., 59 Johnson, L., 537 Miller, Mark Steven, 556 Casanova-Schmitz, Mercedes, 421 Franklin, Michael R., 312 Johnson, Peggy B., 67 Miura, Y., 371 Case, Roger S., 611 Franklin, R. B., 319 Jollow, David J., 451 Miwa, B. J.,70 Cashman, John R., 201 Furuuchi, S., 371 Jondorfl W. R., 597 Montgomery, Mark R., 526 Cenraud, B., 286 Jones, Evelyn C., 481 Moody, D. E., 339 Chambers, Janice E., 611 Gangolli, S. D., 59 JOnsson, S., 590 Mori, Yukio, 387 Chao, Stella T., 10 Garattini, Silvio, 509 Juchau, Mont R., 10 Morris, Patricia L., 126 Chatteiji, Dulal C., 5 Garland. W. A., 70 Moustafa, Mohamed A. A., 574 Chay, Sylvia, 226 Garvie-Gould, C., 109, 293 Kadlubar, Fred F., 531 Miihlebach, S., 597 Chiueh, M. C. C., 70 Gasiewicz, Thomas A., 397 Kajfei,F., 137 Mukhtar, Hasan, 562 Cho, Arthur K., 15,47 Geiger, Lee E., 397 Kalow,W.,2l8 Murphy, S. D., 232 Chowdhury, J. Roy, 426 Giovannini, Maria Grazia, 581 Kammerer, R. Craig, 47 Chowdhury, N. Roy, 426 G#{246}ransson,M., 115 Kappell, B., 70 Nagamatsu, Kunisuke, 152, 190 Claesen, Michel, 574 Gordon, W. P., 164 Karl, Peter I., 611 Nakatsu, K., 463 623 624 AUTHOR INDEX
Nakazawa, Hiroyuki, 167 Prough, R. A., 550 Slikker, William, Jr., 531 Van Dyke, Russell A., 308 Namkung, Moses J., 10 Sloneker, Steven D., 361 Veber, D. F., 147 Narang, Prem K., 5 Ramjit, H. 0., 147 Smith, Robert L., 97 Vermeulen, N. P. E., 489 Nastasi, Linda, 568 Rauckman, Elmer J., 517 Smuckler, E. A., 339 V#{233}zina,Manon, 277 Neal, Robert A., 397 Rendi#{233},S., 137 Solomonraj, G., 277 Vickers, S., 147 Nelson, Rita M., 308 Rhodes,JohnC., 131 Spiegel, James F., 41 vonBahr,C., 115 Nelson,S.D., 164 Rickert,D.,3l9 Steffenrud, Steffen, 255 Nguyen, Cam H., 47 Streeter, A. J., 179, 184 Robertson, Roy, 206,211 Waddell, William J., 172 Noordhoek, Jan, 62 Sullivan, Timothy M., 526 Rodgers, R. M., 109, 293 Wal,J.M.,249 Novak, R. F., 319 Sultatos, L. 0., 232 Roerig, David L, 335, 411 Walle, T., 266,344,394,544 Nugent, Thomas E., 226 Sundheimer, David W., 433 Rosegay, A., 147 Waile, U. K., 266, 344, 394, 544 Nutt,R.F., 147 Suzuki, Toshikazu, 377 Rosen, Gerald M., 517 Walters, D. 0., 59 Rowse, Kim, 226 Wang, Richard 1. H., 335,411 Ohmiya, Yoshio, 25 Rucci, George, 397 Takeyama, Shigeyuki, 377 Watkins,JohnB., 37 Olson, B. A., 441 Ruf, H.-H., 137 Talcott, R. E., 175 Welch, Richard M., 481 O’Neill, Dondra., 5 Rush, 0. F., 441 Tang, B. K., 218 White, S. D., 54 Ortiz, Elsa, 620 Ryrfeldt, A., s o Taylor, L. A., 339 Whitehouse, L. W., 277 Otsuka, M., 371 Taylor, Wesley 0., 404 Williams, Gary M., 556 Sakai, Yoshiyuki, 387 Tephly, T. R., 426 Williams, T. H., 324 Paifreyman, Michael 0, 195 Sasso, 0. J., 324 Terao, Tadao, 152, 190 Wilson, M. J., 394, 544 Pang, K. Sandy, 79 Schanker, Lewis S., 73, 75, 273, 355, Teshima, Reiko, 152 Wisniewski, J. A., 441 Patel, J. M., 164, 620 392, 615 Thal#{233}n,A., 590 Witiak, Donald T., 158 Patrick, J. E., 301 Schmid, Stephen E., 531 Thomas, Barry H., 277 Wong, F. A., 301 Paulsen-SOrman, U., 15 Schmitz, Debra A., 47 Thomas, L. V., 59 Woods, William E., 226 Pazdernik, Thomas L., 366 Schwartz, M. A., 324 Thomas, P. E., 339 Wyss, P. A., 597 Peleran, J. C., 249 Scott, K. F., 109, 293 Timbrell, J. A., 179, 184 Peterson, Francis J., 477 Sgaragli, Giampietro, 581 Tobin, Thomas, 226, 617 Yarbrough, James D., 611 Pohl,LanccR., 126 Shaw,C.J., 301 Toki, Satoshi, 190 Yesair, David W., 206, 211 Pope, Marlene R., 67 Sheikh, Younus M., 158 Toyoshi, Kazumi, 387 Yokoya, Fusayuki, 387 Popick, A., 512 Sheng, L-S., 463 Treston, A. M., 607 Poplack, David 0., 5 Shiverick, Kathleen T., 620 Tschanz, Christian, 517 Postma, E. J., 324 Shull, L. R., 441 Zacchei, A. 0., 54 Poupaert, Jacques H., 574 Sinclair, Keith A., 97 van der Graaff, M., 489 Zeitz, W., 277 Price, Veronica Froble, 451 Sleight, S. D., 441 Vandervorst, Daniel, 574 Zulkoski, J. S., 67 SUBJECT INDEX
Acetaminophen, hepatoxicity, 451 9-Deoxo-16,l6-dimethyl-9-methylene prostaglandin E2, 255 5-Acetylamino-6-formylamino-3-methyluradil, isolation and identifica- Diaminouracil, 206 tion, 218 Diaziquone, pharmacokinetics, 41 3-Acetyl-2-(2,6-dimethyl-5-heptenyl)oxazolidine, hydroxylation by micro- O,O-Diethyl-O-4-nitrophenyl phenylphosphonothioate, metabolism, 31 somes, 404 Digitoxin, 17a-hydroxylation, 85 Aclacinomycin A, in human urine, 167 2,2’-Dihydroxy-3,3’-di-t-butyl-5,5-dimethoxydiphenyl, metabolite of Aerosols, 355 BHA, 581 A-esterases, 232 3,3’-Dimethoxybenzidine, 293 Afloqualone, urinary metabolites, 371 (-)-a-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol, Allyl alcohol, oxidation and hepatotoxicity, 164 377 l-Aminocyclopentanecarboxylic acid (cycloleucine), 75 Dimethylamine 6-Amino-5-(N-methylformylamino)-l,3-dimethyluracil disposition, 509 disposition in the rat, 417, 421 2-Amino-5-phenyl-2-oxazoline-4-one, pemoline, pharmacokinetics, 120 inhalation and metabolism, 417, 421 Amitriptyline, 221 N,N-Dimethyl-4-aminoazobenzene metabolism, 239 Anticonvulsants, 607 4-(Dimethylamino)azobenzene-4’-sulfonyl chloride, 417, 421 Antipyrine 7,l2-Dimethylbenz(a)anthracene, metabolism, 158 metabolic kinetics, 131 Di-n-butyl phthalate metabolism, species differences, 59 metabolism, 517 Drug-induced phospholipidosis, 25 Aromatic amine metabolism, 293 Equine pharmacology, 226 Benzene, 499 Estradiol l7 6, 10 Benzidine, metabolism, 109 Ethanol, 499 Benzo(a)pyrene, 10 7-Ethoxycoumarin, metabolism in trout liver, 494 metabolism, 350, 562 Ethylmorphine, 481 Betamethasone, effects on biphenyl hydroxylation, 556 Extrahepatic metabolism, 62 Biphenyl hydroxylation, 556 N,N’-Bis(2-chloroethyl)-N-thtrosourea (BCNU), glutathione-dependent Flurazepam, metabolism, 70 denitrosation, 175 Furosemide, 226 $-Blocker, 91 Bromperidol, metabolism, 301 Budesonide, metabolism, 590 Glucose analogs, 273 Bumetanide, metabolism, 512 t-Butylmorphine, 481 Halothane, 308 Harmol, metabolism and transport, 433 Caffeine Hematin, 10 metabolism in nonsmoking populations, 211 Hepatotoxins, 312 metabolite, 5-acetylamino-6-formylamino-3-methyluradil, 218 2,2’,4,4’,5,5’-Hexachlorobiphenyl disposition, 597 metabolites, 206 Hexobarbital enantiomers, disposition, 489 Carbamazepine, 286 Hydralazine Carbinolamine, 47 covalent binding, 179 Carbon tetrachioride metabolism, 329 metabolism, 184 CCLI, metabolism, 329 Hydrazine metabolism, 550 Chloramphenicol N-Hydroxyacetanalide, 103 dechlorination, 126 N-Hydroxy-2-acetylaminofluorene, 103 metabolic profiles in rat, man, and goat, 249 N-Hydroxy-2-acetylaminonaphthalene, 103 Chiordecone, 329 N-Hydroxy-p-chloroacetanilide, 103 Chiorphentermine, 25 N-(5-Hydroxypentyl)-l-phenylcyclohexylamine, 47 pulmonary disposition, 25 N-Hydroxyphenacetin, 103, 471 Chlorpromazine, 221 metabolism in small intestine and liver, 244 Imidazobenzodiazeprine, metabolism, 324 N-oxide, 25 Imipramine, 221 Chlorpyrifos oxon, 232 Imipramine, uptake and efflux, 361 Cimetidine, 137 Imipramine N-oxide, 25 Citronella!, N-acetyloxazoilidine derivative, 404 Inorganic fluoride, 308 Clobazam, 286 Insect repellent, 404 Clofibrate and clofibric acid, metabolic conjugation, 97 Intrinsic clearance, 62 Codeine, 481 In vitro metabolism, 47 demethylation, 477 Isotope effect, allyl alcohol metabolism and toxicity, 164 Cytochrome P-450, 275, 339, 499 Isotretinoin bioavailability, 458 interactions, 137 stability in lyophilized microsomes, 620 subpopulations, 312 Ketone production, 451 Cytochrome P-450a, immunochemical location, 339 Ketotifen metabolism, 585
625 626 SUBJECT INDEX
l-a-Acetylmethadol Parathion, hemoperfusion and pharmacokinetics, 366 metabolism and distribution, 411 Phenacetin analogs, 471 pulmonary uptake, 411 Phenazopyridine, metabolite 2,6-diamino-5-hydroxy-3-(phenylazo)-pyri- Lung permeability, 73, 75 dine, 277 Lyophilized microsomes, stability ofenzymes, 620 Phencycidine, 47 Phenobarbital, 329,441,607 Mepindolol sulfate, 91 1-Phenylcyclohexylamine, 47 6-Mercaptopurine, pharmacokinetics, 5 5-(l-Phenylcyclohexylamino)valeric acid, 47 Metabolite formation, kinetic estimation, 79 N-(l-Phenylcyclohexyl)-l,2,3,4-tetrahydmpytidine, 47 Meta-hydroxylation, 574 Phenytoin, metabolism, 21, 574 Metaproterenol, 568 Pholcodine, 481 Mctaprotcrenol-3-O-sulfatc, 568 Prazosin hydrochloride, first-pass metabolism, 143 Methadone Primidone, 607 brain level, 335 Procarbazine metabolism, 550 brain and plasma correlation, 335 Propranolol 3-O-(+)-f’4ClMethyl-catechin metabolism, 602 intravenous kinetics of enantiomers, 394 3-Methylcholanthrenc, 441 metabolism, sulfate conjugates, 344 (+)-5-Methyl- 10, 1 l-dihydro-5H-dibenzofa,d)cyclohcpten-5, 10- metabolites, 544 iniine, metabolic disposition, 54 quantitative metabolic fate, 266 2-Methylnaphthalcne, 319 stereoselective plasma binding, 394 distribution, metabolism, 152 Pulmonary absorption, 73, 75, 273, 355 S-(7-Methyl-l-naphthyl)cystcine, 152 neonatal guinea pig, 615 S-(7-Methyl-l-naphthyl)glutathione, 152 sex comparison in the rat, 392 O-Methyloxime, 47 L-Pyro-2-aminoadipyl-L-hlstidyl[3H)-L-thioazolidine-4-carboxamide N-Methyl-2-phcnethylamines, N-demethylation, 15 (MK-77l), metabolism, 147 MFO inhibition by Cd or Zn, 67 Mink, effects ofphenobarbital and 3-methylcholanthrene, 441 Quaternary ammonium compounds, 73 Minoxidil sulfate, 507 Quaternary ammonium-linked glucuronides, 221 Mire; 329 cLi’. and trans-5,l0 dihydrogen, metabolism, 611 Racing medication, 226 Monooxygenases, 10 R.anitidine,137 Morphine, 481 14C-labeled, autoradiography, 172 metabolite, 190 Stereoselective binding of(-)-propranolol, 394 Morphine-3-alkyl ethcrs pharmacokinetics and O-dealkylation, 481 Steroid 3- and 17-hydroxy glucuroaldation, 426 Morphinone, 190 Steroids, cytochrome P-450 oxidation, 531 Morphinone-glutathione conjugate, 190 Styrene oxide, 463 Suprofen, absorption and excretion, 387
NADPH-cytochrome c reductase, stability in lyophilized microsomes, 620 Nortriptyline; E- and Z-lO-hydroxylation, 115 2,3,7,8-Tetrachlorodibenzo-p-dioxin, metabolism and disposition, 397 Thiobenzamide, 201 Oxymorphone, 446 Thobenzamide-S-oxide, 201 Oxyphenbutazone, 617 4,4’-Thiobis(6-:-butyl-m-cresol), 537 Tiodazosin levulinate, pharmacokinetics, 143 Para-hydroxylation, 574 Traumatic injury, 517 Paraoxon, 232 hemoperfusion and pharmacokinetics, 366 UDPGA, alteration in rat liver, 37 Paraquat, covalent binding in lung, 526 UDP-glucuronyltransferasc, stability in lyophilized microsomes, 620