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Neurological Disease

A range of neurological disorders, including and , may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in and the loss of in nigrostriatum, associated with rigidity, resting , gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, , peripheral neuropathy, migraine, , strokelike episodes and and depend on the part of the affected.

www.MedChemExpress.com 1 Neurological Disease Inhibitors & Modulators

(+)- hydrochloride hemihydrate (+)- hydrochloride Cat. No.: HY-76772A (DAR-0100 hydrochloride) Cat. No.: HY-101299

Bioactivity: Cevimeline hydrochloride hemihydrate, a novel muscarinic Bioactivity: (+)-Dihydrexidine hydrochloride is a dopamine D1 receptor , is a candidate therapeutic for agonist with an EC50 of 72± 21 nM. in Sjogren's syndrome. IC50 value: Target: mAChR The general pharmacol. properties of this drug on the gastrointestinal, urinary, and reproductive systems and other… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 mg, 5 mg

(+)-MK 801 Maleate (+)-PD 128907 hydrochloride ( maleate; Dizocilpine hydrogen maleate) Cat. No.: HY-15084 Cat. No.: HY-110000

Bioactivity: (+)-MK 801 Maleate is a potent, selective and non-competitive Bioactivity: (+)-PD 128907 hydrochloride is a selective dopamine D2/D3 NMDA with Kd of 37.2 nM in rat brain receptor agonist, with Kis of 1.7, 0.84 nM for human and rat D membranes. 3 receptors, 179, 770 n M for human and rat D 3 receptors, respectively. Purity: 99.98% Purity: 98.83% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg

(+)- (-)-(S)-Equol Cat. No.: HY-16009 Cat. No.: HY-100583

Bioactivity: Posiphen is a novel selective noncompetitive Bioactivity: (-)-(S)-Equol is a high affinity for receptor

inhibitor with an IC50 of 45.3 μM. β with a Ki of 0.73 nM.

Purity: >98% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg

(-)- (-)- ((R)-Aspartic acid; D-(-)-Aspartic acid) Cat. No.: HY-42068 (L-Borneol) Cat. No.: HY-N1368B

Bioactivity: (-)-Aspartic acid is an endogenous NMDA receptor agonist. Bioactivity: (-)-Borneol has a highly efficacious positive modulating

action at GABA receptor with an EC50 of 237 μM.

Purity: 97.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g 100 mg

(-)-Cevimeline hydrochloride hemihydrate (-)- Cat. No.: HY-76772B (Huperzine A) Cat. No.: HY-17387

Bioactivity: Cevimeline hydrochloride hemihydrate, a novel muscarinic Bioactivity: Huperzine A, an active Lycopodium extracted from receptor agonist, is a candidate therapeutic drug for traditional Chinese herb, is a potent, selective and xerostomia in Sjogren's syndrome. IC50 value: Target: mAChR reversible (AChE) inhibitor and has been The general pharmacol. properties of this drug on the widely used in China for the treatment of Alzheimer's disease gastrointestinal, urinary, and reproductive systems and other… (AD). Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 5 mg, 10 mg

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

(-)-MK 801 Maleate (-)-Securinine Cat. No.: HY-15084A Cat. No.: HY-N2079

Bioactivity: (-)-MK 801 Maleate is the enantiomer of (+)-MK-801. (+)-MK 801 Bioactivity: (-)- is plant-derived alkaloid and also a GABAA Maleate is a potent, selective and non-competitive NMDA receptor antagonist. receptor antagonist.

Purity: 99.70% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 25 mg

(1R,2R)-2-PCCA(hydrochloride) (1R,2S)-VU0155041 Cat. No.: HY-100013A1 Cat. No.: HY-14417A

Bioactivity: (1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and Bioactivity: (1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial

acts as a potent GPR88 receptor agonist, with an EC50 of 3 mGluR4 agonist with an EC50 of 2.35 μM. nM.

Purity: 98.08% Purity: 98.42% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 25 mg

(Arg)9 (R)-(-)- (Nona-L-arginine; R9) Cat. No.: HY-P0133 ((R)-Rolipram; (-)-Rolipram) Cat. No.: HY-16900A

Bioactivity: (Arg)9 (Nona-L-arginine;Peptide R9) is a cell-penetrating Bioactivity: (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is

peptide; exhibits neuroprotective activity with an IC50 of a selective inhibitor of phosphodiesterases PDE4 with IC50 of 0.78 μM in the model. Sequence: 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg. respectively.

Purity: >98% Purity: 99.85% Clinical Data: Phase 2 Clinical Data: Phase 1 Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

(R)-5-Hydroxymethyl (R)-ADX-47273 (; PNU-200577) Cat. No.: HY-76569 Cat. No.: HY-13058B

Bioactivity: (R)-5-Hydroxymethyl Tolterodine(PNU-200577; Desfesoterodine) Bioactivity: (R)-ADX-47273 is a potent mGluR5 positive allosteric is a potent and selective muscarinic receptor antagonist with modulator, with an EC50 of 168 nM for potentiation . a Kb and a pA2 of 0.84 nM and 9.14, respectively.

Purity: 99.66% Purity: 99.25% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

(R)- (R)-Baclofen hydrochloride (STX209) Cat. No.: HY-17354 (STX 209 hydrochloride) Cat. No.: HY-17354A

Bioactivity: (R)-Baclofen(STX209) is a selective GABAB receptor agonist. Bioactivity: (R)-Baclofen Hcl(STX-209 Hcl) is a derivative of IC50 value: Target: GABAB receptor GABAB receptors are gamma-aminobutyric acid (GABA) primarily used to treat metabotropic receptors which produce slow inhibitory signals. and is in the early research stages for use for the By manipulating GABAB receptor activity using Baclofen, a treatment of alcoholism. Target: GABA Baclofen (brand names variety of functions are studied including synaptic… Kemstro, Lioresal, Liofen, Gablofen, Beklo and Baclosan) is a… Purity: 98.0% Purity: >98% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10mM x 1mL in Water, Size: 10 mg, 50 mg 10 mg, 50 mg

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(R)-Oxiracetam (RS)-MCPG ((R)-(+)-) Cat. No.: HY-17554 (alpha-MCPG) Cat. No.: HY-100371

Bioactivity: (R)-Oxiracetam is the (R)-enantiomer of the drug Bioactivity: (RS)-MCPG is a non-selective group I/group II metabotropic oxiracetam. Oxiracetam (ISF 2522) is a nootropic drug of the antagonist. family and .

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

(S)-(-)-5-Fluorowillardiine (S)-(-)-5-Fluorowillardiine hydrochloride ((5S)-Fluorowillardiine; (S)-5-Fluorowillardiine) Cat. No.: HY-16713 ((5S)-Fluorowillardiine hydrochloride; …) Cat. No.: HY-16713A

Bioactivity: (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR Bioactivity: (S)-(-)-5-Fluorowillardiine Hcl is a potent and specific AMPAR agonist. agonist.

Purity: >98% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

(S)-Glutamic acid (S)-MCPG ((+)-L-Glutamic acid) Cat. No.: HY-14608 ((+)-MCPG) Cat. No.: HY-100406

Bioactivity: (S)-Glutamic acid acts as an excitatory transmitter, shows a Bioactivity: (S)-MCPG is the active isomer of (RS)-MCPG (Cat. No. direct activating effect on the release of DA from HY-100371), non-selective group I/group II metabotropic terminals. glutamate receptor antagonist. In vivo: (S)-MCPG (20.8 μg) injected intraventricularly (i.c.v.) before testing impaired the performance of rats in the spatial version of the Morris… Purity: >98% Purity: 98.10% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg

(S)- Maleate (S)- (Timolol Maleate) Cat. No.: HY-17380 ((-)-Willardiine) Cat. No.: HY-12499

Bioactivity: (S)-Timolol maleate, is a potent non-selective β- Bioactivity: (S)-Willardiine is a potent agonist of AMPA/kainate receptors receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and with EC50 of 44.8 uM. IC50 value: 44.8 uM(EC50) [1] Target: β2 receptor subtypes respectively). IC50 Value: 1.97 nM(Ki for AMPA/ agonist in vitro: The (S)- but not β1); 2.0 nM(Ki for β2) Target: β- (R)-isomers of willardiine and 5-bromowillardiine were potent (S)-Timolol, 50% following oral… , producing rapidly but incompletely desensitizing… Purity: 99.87% Purity: 98.70% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 200 mg 10 mg, 50 mg

(Z)-Hexadec-9-enoic acid (Z)-Thiothixene Cat. No.: HY-W011873 Cat. No.: HY-108324

Bioactivity: (Z)-Hexadec-9-enoic acid, a composition of , is Bioactivity: (Z)-Thiothixene is an antagonist of receptor implicated in the prevention of from cerebrovascular extracted from patent US 20150141345 A1. disorders in SHRSP rats.

Purity: >98% Purity: 99.14% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg

4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

(±)-Epibatidine (±)-Equol (CMI 545) Cat. No.: HY-101078 Cat. No.: HY-100583A

Bioactivity: (±)- is a . (±)-Epibatidine is a Bioactivity: (±)-Equol is the racemate of equol. Equol is a metabolite of neuronal nAChR agonist. the soy isoflavones, daidzin and .

Purity: >98% Purity: 99.01% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg

(±)-Huperzine A (±)-Tazifylline Cat. No.: HY-17388 Cat. No.: HY-U00018

Bioactivity: Huperzine A, an active Lycopodium alkaloid extracted from Bioactivity: (±)-Tazifylline is a potent, selective and long-acting traditional Chinese herb, is a potent, selective and H1 receptor antagonist. reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE Huperzine A exhibited… Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg

1,3-Dicaffeoylquinic acid 11β-HSD1-IN-1 (1,3-O-Dicaffeoylquinic acid; 1,5-Dicaffeoylquinic acid) Cat. No.: HY-N1412 Cat. No.: HY-U00325

Bioactivity: 1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative, Bioactivity: 11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 and activates PI3K/Akt. (11β-HSD1), with an IC50 of 52 nM, and used for the treatment of .

Purity: 99.82% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg

18:0 LYSO-PE 2,2,2- (Stearoyl lysophosphatidylethanolamine) Cat. No.: HY-103660 (Tribromoethyl ) Cat. No.: HY-B1372

Bioactivity: Stearoyl lysophosphatidylethanolamine is an agent that can Bioactivity: 2,2,2-Tribromoethanol is an injectable agent used 2+ in mice. induce [Ca ] i increase.

Purity: >98% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 g

2-Amino-6-methylheptane hydrochloride 2-Arachidonoylglycerol Cat. No.: HY-B1233A Cat. No.: HY-W011051

Bioactivity: 2-Amino-6-methylheptane hydrochloride is a Bioactivity: 2-Arachidonoylglycerol is a second endogenous and vasoconstrictor, but mainly as a pharmaceutical ligand in the . intermediate of octamylamine.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 g

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2-Hydroxy-3-methylbutanoic acid 2-Hydroxyphenylacetic acid Cat. No.: HY-W008150 Cat. No.: HY-W015590

Bioactivity: 2-Hydroxy-3-methylbutanoic acid is a close structure analogue Bioactivity: 2-Hydroxyphenylacetic acid is a potential biomarker for the of GHB, which is a naturally occurring and a food products, and found to be associated with phenylketonuria . (PKU).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 g

2-PCCA(hydrochloride) 2-Phenylethanamine Cat. No.: HY-100013C Cat. No.: HY-W010483

Bioactivity: 2-PCCA hydrochloride is a GPR88 receptor agonist, and Bioactivity: 2-Phenylethanamine is believed to function as a neuromodulator or neurotransmitter. inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.

Purity: 99.61% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg Size: 1 g

2-PMPA 24-Hydroxycholesterol (2-(Phosphonomethyl)pentanedioic acid) Cat. No.: HY-100788 Cat. No.: HY-N2370

Bioactivity: 2-PMPA is a potent and selective inhibitor of glutamate Bioactivity: 24-Hydroxycholesterol is a natural sterol, which serves as a

carboxypeptidase II ( GCPII) with an IC50 of 300 pM. positive of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 2 mg, 5 mg

2614W94 2: PN: US20040072744 SEQID: 2 claimed protein Cat. No.: HY-101578 Cat. No.: HY-U00372

Bioactivity: 2614W94 is a selective, reversible inhibitor of monoamine Bioactivity: 2: PN: US20040072744 SEQID: 2 claimed protein is a synthetic peptide, used for the research of Down's syndrome and oxidase-A with a competitive mechanism of inhibition and IC50 . of 5 nM and Ki of 1.6 nM with as substrate.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg

3'-Methoxyflavonol 3-Indolepropionic acid Cat. No.: HY-N6629 Cat. No.: HY-W015229

Bioactivity: 3'-Methoxyflavonol is a selective agonist of 2 Bioactivity: 3-Indolepropionic acid is shown to be a powerful receptor ( NMU2R). and has potential in the treatment for Alzheimer’s disease.

Purity: 99.79% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 1 g

6 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

3-Methoxytyramine 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine) Cat. No.: HY-103638A (3-O-methyl Dopamine hydrochloride) Cat. No.: HY-103638

Bioactivity: 3-Methoxytyramine, a well known extracellular metabolite of Bioactivity: 3-Methoxytyramine hydrochloride is an inactive metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator. dopamine which can activate trace associated receptor 1 ( TAAR1).

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 250 mg, 500 mg 100 mg, 250 mg, 500 mg, 1 g

4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 4-(6-Bromo-2-benzothiazolyl)benzenamine Cat. No.: HY-111513 Cat. No.: HY-111514

Bioactivity: 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent Bioactivity: 4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET amyloid imaging agent which binds to Amyloid-β (1-40) with (positron emission tomography) tracer that can be used in the

a KD of 1.7 nM. diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.

Purity: 98.60% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10 mg, 50 mg

4-Methyl-2-oxopentanoic acid 450191S Cat. No.: HY-W012722 Cat. No.: HY-U00228

Bioactivity: 4-Methyl-2-oxopentanoic acid, an abnormal metabolite, is both Bioactivity: 450191S is a new sleep inducer. a and a metabotoxin.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 1 mg, 5 mg, 10 mg, 20 mg

4E2RCat 5-Aminovaleric acid Cat. No.: HY-100733 Cat. No.: HY-W015878

Bioactivity: 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 Bioactivity: 5-Aminovaleric acid is believed to act as a methylene of 13.5 μM. homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

5-Chloro-2'-deoxyuridine 5-HT1A modulator 1 (5-Chlorodeoxyuridine; CldU) Cat. No.: HY-112669 Cat. No.: HY-100290

Bioactivity: 5-Chloro-2'-deoxyuridine, a thymine analog, is to study the Bioactivity: 5-HT1A modulator 1 displays very high affinities for the

potential of hypochlorous acid damage to DNA and DNA 5HT1A, adrenergic α1 and dopamine D2 receptor with precursors. IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.

Purity: 99.92% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg, 100 mg

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5-HT3 antagonist 2 5-HT3-In-1 Cat. No.: HY-U00408 Cat. No.: HY-U00413

Bioactivity: 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist. Bioactivity: 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. It shows 5-HT3 inhibition activity.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

5-HT4 antagonist 1 5-HT7 agonist 1 Cat. No.: HY-100170 Cat. No.: HY-109527

Bioactivity: 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a Bioactivity: 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor pKi of 9.6. related disease, such as CNS disorders.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 250 mg, 500 mg

5-Hydroxyindole-3-acetic acid 5HT6-ligand-1 Cat. No.: HY-W008253 Cat. No.: HY-U00126

Bioactivity: 5-Hydroxyindole-3-acetic acid is the main metabolite of Bioactivity: 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of serotonin or , which can be used as a biomarker 1.43 nM. of neuroendocrine tumors.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

6"-O-Apiosyl-5-O-Methylvisammioside 6,2'-Dihydroxyflavone Cat. No.: HY-N2295 Cat. No.: HY-N6628

Bioactivity: 6”-O-Apiosyl-5-O-Methylvisammioside is one of the components Bioactivity: 6,2'-Dihydroxyflavone is a novel antagonist of GABAA of the traditional Chinese medicine Kang-Jing. receptor.

Purity: 99.87% Purity: 99.10% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg 50 mg

6-Biopterin 6-Hydroxymelatonin (L-Biopterin) Cat. No.: HY-102015 Cat. No.: HY-W011956

Bioactivity: 6-Biopterin (L-Biopterin), a pterin derivative, is a NO Bioactivity: 6-Hydroxymelatonin is a primary metabolic of , synthase . which is metabolized by (CYP) 1A2.

Purity: 98.02% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

8 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

6-Methoxy-2-naphthoic acid 6-Methylflavone ( impurity O) Cat. No.: HY-B2121 Cat. No.: HY-N6630

Bioactivity: 6-Methoxy-2-naphthoic acid is an NMDA Bioactivity: 6-methylflavone is an activator of α 1β 2γ 2L and α 1β 2 extracted from patent WO 2012019106 A2. GABAA receptors.

Purity: 98.0% Purity: 99.85% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

7-Chloro-4-hydroxyquinoline-2-carboxylic acid 7-Chlorokynurenic acid sodium salt (7-Chlorokynurenic acid) Cat. No.: HY-100811 Cat. No.: HY-100811A

Bioactivity: 7-Chlorokynurenic acid is a selective antagonist at the Bioactivity: 7-Chlorokynurenic acid sodium salt is a selective antagonist modulatory site of the N-methyl-D-aspartate at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the receptor complex and also a potent inhibitor of the reuptake

of glutamate into synaptic vesicles with a Ki of 0.59 μM. of glutamate into synaptic vesicles with a Ki of 0.59 μM.

Purity: 99.62% Purity: 99.79% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

8-Hydroxyguanosine 8-OH-DPAT Cat. No.: HY-113262 (8-Hydroxy-DPAT) Cat. No.: HY-112061

Bioactivity: 8-Hydroxyguanosine is a systematic marker of oxidative stress Bioactivity: 8-OH-DPAT is a potent and selective 5-HT agonist, with a and a marker of hydroxyl radical damage to RNA. pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7;

8-OH-DPAT weakly binds to 5-HT1B (pIC 50, 5.42), 5-HT (pIC

50 <5). Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

A 438079 A 438079 (hydrochloride) Cat. No.: HY-15488 Cat. No.: HY-15488A

Bioactivity: A 438079 is a potent, and selective P2X7 Bioactivity: A 438079 (hydrochloride) is a potent, and selective P2X receptor antagonist with pIC 50 of 6.9. receptor antagonist with pIC 50 of 6.9. 7

Purity: 99.64% Purity: 99.74% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg 10 mg, 50 mg

A 839977 A-1165442 Cat. No.: HY-13954 Cat. No.: HY-12428

Bioactivity: A-839977 is a novel and selective P2X7 antagonist; blocks Bioactivity: A-1165442 is a potent, competitive and orally available TRPV1

BzATP-evoked calcium influx at recombinant human, rat and antagonist with an IC50 of 9 nM for human TRPV1. mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively).

Purity: 98.05% Purity: 99.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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A-317491 A-317491 sodium salt hydrate Cat. No.: HY-15568 Cat. No.: HY-15568A

Bioactivity: A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor Bioactivity: A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the antagonist, which inhibits calcium flux mediated by the receptors. IC50 value: Target: P2X2/3 It is known that P2X3 receptors. IC50 value: Target: P2X2/3 receptor It is known and P2X2/3 receptors stimulate the pronociceptive effects of that P2X3 and P2X2/3 receptors stimulate the pronociceptive ATP upon activation. Studies indicate that the P2X3 receptor… effects of ATP upon activation. Studies indicate that the P2X3… Purity: 99.56% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

A-437203 A-740003 (Lu201640; A37203) Cat. No.: HY-U00185 Cat. No.: HY-50697

Bioactivity: A-437203 is a selective D3 receptor antagonist with Ki of Bioactivity: A-740003 is a potent, selective and competitive P2X7 receptor antagonist with IC values are 18 and 40 nM for rat 71, 1.6, and 6220 nM for D 2, D 3, and D 4 receptors, 50 respectively. and human P2X7 receptors, respectively.

Purity: >98% Purity: 98.91% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

A-803467 A-836339 Cat. No.: HY-11079 Cat. No.: HY-12761

Bioactivity: A 803467 is a selective Nav1.8 blocker with an Bioactivity: A-836339 is a cannabinoid CB2 receptor-selective agonist; IC50 of 8 nM; over 100-fold more selective . human Nav1.2, exhibits high potencies at CB(2) and selectivity over CB(1) 1.3, 1.5 and 1.7. receptors.

Purity: 97.51% Purity: 99.61% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg

A-867744 A2A receptor antagonist 1 Cat. No.: HY-12149 Cat. No.: HY-102024

Bioactivity: A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 Bioactivity: A2A receptor antagonist 1 is an antagonist of both values are 0.98 and 1.12 μM for human and rat α7 receptor A2A receptor and A1 receptor with Kis of 4 and 264 nM, ACh-evoked currents respectively, in X. laevis oocytes). respectively. Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. IC50 value: ~ 1 uM Target: α7 nAChR Target: Purity: 99.92% Purity: 98.25% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

A2AR-agonist-1 AB-MECA Cat. No.: HY-18776 Cat. No.: HY-19365

Bioactivity: A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of Bioactivity: AB-MECA is a high affinity A3 agonist, has 4.39 and 3.47 for A2AR and ENT1. high affinity for recombinant A1 and A3 receptors.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg

10 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Abaperidone ABT 894 Cat. No.: HY-101619 (A 422894.0; Sofiniclin) Cat. No.: HY-14824

Bioactivity: Abaperidone is a potent antagonist of 5-HT2Areceptor and Bioactivity: ABT 894 is an agonist of nicotinic receptor dopamine D receptor with IC s of 6.2 and 17 nM. (nAChR), used as a potential non-stimulant treatment for 2 50 -deficit/hyperactivity disorder (ADHD).

Purity: >98% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

ABT-239 ABT-639 Cat. No.: HY-12195 Cat. No.: HY-19721

Bioactivity: ABT-239 is a novel, highly efficacious, Bioactivity: ABT-639 is a novel, peripherally acting, selective T-type non- class of H3R antagonist and a transient Ca2+ . receptor potential vanilloid type 1 ( TRPV1) antagonist.

Purity: 98.94% Purity: 99.15% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

ABT-639 hydrochloride Ac-Leu-Arg-AMC Cat. No.: HY-101616 Cat. No.: HY-P1448

Bioactivity: ABT-639 hydrochloride is a novel, peripherally acting, Bioactivity: Ac-Leu-Arg-AMC is a fluorogenic peptide substrate. Sequence: selective T-type Ca2+ channel blocker. Ac-Leu-Arg-AMC.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg

AC260584 calcium Cat. No.: HY-100336 (Calcium N-acetylhomotaurinate) Cat. No.: HY-17030

Bioactivity: AC260584 is an M1 muscarinic receptor allosteric agonist Bioactivity: Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of systems; reduces alcohol with a pEC50 of 7.6. consumption in animal models of alcohol addiction. IC50 value: Target: GABA receptor Acamprosate, or N-acetyl , is an N-methyl-D-aspartate receptor modulator approved by the… Purity: 98.02% Purity: 98.13% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 50 mg

Aceglutamide Acetylcholine chloride (α-N-Acetyl-L-; N2-Acetylglutamine) Cat. No.: HY-B1065 (Ach; ACh chloride) Cat. No.: HY-B0282

Bioactivity: is a psychostimulant and nootropic, used to Bioactivity: Acetylcholine is a neurotransmitter that can induce the improve and concentration. opening of calcium channels. Target: ; nAChR; mAChR Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector… Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 1 g, 5 g

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Acetylcysteine ACTH 1-17 (N-Acetyl-L-cysteine; LNAC; NAC) Cat. No.: HY-B0215 (α1-17-ACTH) Cat. No.: HY-P1545

Bioactivity: is a mucolytic agent which reduces the Bioactivity: ACTH (1-17), an adrenocorticotropin analogue, is a potent

thickness of the mucus. human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 g, 10 g

ACY-775 Ademetionine (S-Adenosyl-L-; S-Adenosyl methionine; Cat. No.: HY-19328 SAMe; AdoMet) Cat. No.: HY-B0617

Bioactivity: ACY-775 is a potent and selective inhibitor of the of histone Bioactivity: Ademetionine is an intermediate metabolite of methionine. Its

deacetylase 6 ( HDAC6) with an IC50 of 7.5nM. involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several and that affect mood. Purity: 99.54% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 50 mg, 100 mg, 500 mg

Adenosine 5'-monophosphate monohydrate Adenosine antagonist-1 (5'-AMP monohydrate) Cat. No.: HY-A0181A Cat. No.: HY-100274

Bioactivity: Adenosine 5'-monophosphate monohydrate is an adenosine A1 Bioactivity: Adenosine antagonist-1 is an adenosine A3 receptor ( AA3R) receptor agonist. antagonist.

Purity: 99.07% Purity: >98% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg 1 g

Adiphenine hydrochloride ADL-5859 Cat. No.: HY-B0379A Cat. No.: HY-13044

Bioactivity: Adiphenine HCl is a nicotinic receptor inhibitor, used as an Bioactivity: ADL5859 is a δ- receptor agonist with Ki of 0.8 nM, drug. selectivity against κ, μ, and weak inhibitory activity at the hERG channel.

Purity: 99.62% Purity: 99.65% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Adoprazine ADX-47273 (SLV313) Cat. No.: HY-14782 Cat. No.: HY-13058

Bioactivity: Adoprazine, a potential atypical bearing potent Bioactivity: ADX-47273 is a positive allosteric modulator selective for the D2 receptor antagonist and 5-HT1A receptor agonist properties. metabotropic glutamate receptor subtype mGluR5(EC50=170 nM). IC50 value: 170 nM(EC50) [1] [2] Target: positive allosteric modulator (PAM) of mGluR5 in vitro: ADX-47273 increased (9-fold) the response to threshold concentration of glutamate… Purity: 98.13% Purity: 99.34% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

12 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

ADX88178 Cat. No.: HY-18654 Cat. No.: HY-B1833

Bioactivity: ADX88178 is a potent positive allosteric modulator for Bioactivity: Afloqualone is a agonist of GABA receptor .

metabotropic glutamate receptor 4 ( mGluR4) with EC50 of 4 nM for human mGluR4.

Purity: 98.59% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg

Aftin-4 sulfate Cat. No.: HY-111267 Cat. No.: HY-101238

Bioactivity: Aftin-4 is an Amyloid-β42 ( Aβ42) inducer. Bioactivity: Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and synthesis. It is an endogenous agonist at and a NO synthase inhibitor. Purity: 98.13% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 100 mg, 500 mg, 1 g

Agomelatine hydrochloride Cat. No.: HY-17038 (S-20098 hydrochloride) Cat. No.: HY-17038A

Bioactivity: Agomelatine is a competitive antagonist of human and porcine Bioactivity: Agomelatine hydrochloride is a , which is serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) classified as a -dopamine disinhibitor (NDDI) as well as human 5-HT2B receptors (pKi = 6.6). due to its antagonism of the 5-HT2C receptor.

Purity: 99.88% Purity: 99.49% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Agomelatine L(+)-Tartaric acid AK-7 (S-20098 L(+)-Tartaric acid) Cat. No.: HY-17038B Cat. No.: HY-16691

Bioactivity: Agomelatine (L(+)-Tartaric acid) is a antidepressant, which is Bioactivity: AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, classified as a norepinephrine-dopamine disinhibitor (NDDI) with an IC50 of 15.5 μM. due to its antagonism of the 5-HT2C receptor.

Purity: >98% Purity: 99.59% Clinical Data: Launched Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Alimemazine hemitartrate hydrochloride (Trimeprazine hemitartrate) Cat. No.: HY-12752A Cat. No.: HY-A0125A

Bioactivity: hemitartrate is a derivative that is Bioactivity: Alizapride hydrochloride is a antagonist generally used as an agent and also a with prokinetic and effects which can also be used hemagglutinin ( HA)- receptor antagonist. in the treatment of and , including postoperative nausea and vomiting.

Purity: 98.92% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 50 mg, 100 mg

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Allopregnanolone mesylate (Almitrine bismesylate; Almitrine (3α,5α-THP; SAGE-547; Brexanolone) Cat. No.: HY-101107 bismethanesulfonate; Almitrine dimesylate) Cat. No.: HY-107319

Bioactivity: is a metabolite. Bioactivity: Almitrine mesylate, a peripheral chemoreceptor agonist, Allopregnanolone is an allosteric modulator of the GABA inhibits selectively the Ca 2+-dependent K+ channel. receptor.

Purity: 98.0% Purity: 99.36% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

Almorexant hydrochloride (ACT 078573) Cat. No.: HY-10805 (ACT-078573 hydrochloride) Cat. No.: HY-10805A

Bioactivity: Almorexant(ACT078573) is a potent and competitive dual Bioactivity: Almorexant Hcl (ACT078573) is a potent and competitive dual 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist values of 1.3 and 0.17 nM for OX1 and OX2, respectively. IC50 with Ki values of 1.3 and 0.17 nM for OX1 and OX2, value: 1.3/0.7 nM(OX1/OX2 receptor) [1] [2] Target: Dual respectively. OX!/OX2 receptor in vitro: [(3)H]Almorexant bound to a single… Purity: 99.17% Purity: 99.88% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Alniditan (Alnitidan) Cat. No.: HY-101698 (GR 68755; GR 68755X) Cat. No.: HY-70050A

Bioactivity: is a potent 5-HT1B/1D receptors agonist, with Bioactivity: Alosetron is a Serotonin 5HT3-receptor antagonist that is used in treatment of . IC50 of 1.7 and 1.3 nM in HEK293 cells, and pKi value of 8.96

and 9.40 for 5-HT 1B/1D receptors, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10 mg, 50 mg

Alosetron (Z)-2-butenedioate Alosetron Hydrochloride (GR 68755; GR 68755X) Cat. No.: HY-70050B (GR 68755C; GR 68755; GR 68755X) Cat. No.: HY-70050C

Bioactivity: Alosetron is a Serotonin 5HT3-receptor antagonist that is used Bioactivity: Alosetron Hcl is a Serotonin 5HT3-receptor antagonist that is in treatment of irritable bowel syndrome. used in treatment of irritable bowel syndrome.

Purity: >98% Purity: 99.72% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Alosetron Hydrochloride(1:X) Aloxistatin (GR 68755; GR 68755X) Cat. No.: HY-70050 (E64d; E64c ethyl ester) Cat. No.: HY-100229

Bioactivity: Alosetron is a Serotonin 5HT3-receptor antagonist that is used Bioactivity: Aloxistatin (E64d) is a cell-permeable and irreversible in treatment of irritable bowel syndrome. broad-spectrum cysteine protease inhibitor.

Purity: >98% Purity: 98.22% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg

14 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Alpertine alpha-Asarone (Win 31665) Cat. No.: HY-U00243 (α-Asarone; trans-Asarone) Cat. No.: HY-N0700

Bioactivity: Alpertine is an antipsychotic agent extracted from patent US Bioactivity: Alpha-Asarone is one of the main psychoactive compounds, and 5955459 A. possesses an antidepressant-like activity in mice.

Purity: >98% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

Alvameline dihydrate (Lu 25-109) Cat. No.: HY-101586 (LY 246736 dihydrate; ADL 8-2698 dihydrate) Cat. No.: HY-76657A

Bioactivity: (Lu25-109) is a partial M1 agonist and M2/M3 Bioactivity: Alvimopan dihydrate(LY 246736; ADL 8-2698) is a peripherally antagonist. acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after .

Purity: >98% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Alvimopan monohydrate AM-0902 Cat. No.: HY-76657 Cat. No.: HY-108329

Bioactivity: Alvimopan monohydrate is a peripherally acting mu-opioid Bioactivity: AM-0902 is a potent, selective transient receptor potential A1

receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating ( TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 gastrointestinal recovery after surgery. and hTRPA1, respectively.

Purity: 99.06% Purity: 99.39% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

AM-2099 AM251 Cat. No.: HY-100727 Cat. No.: HY-15443

Bioactivity: AM-2099 is a potent and selective inhibitor of voltage-gated Bioactivity: AM251 is a selective cannabinoid 1 ( CB1) receptor antagonist sodium channel Nav1.7 with an IC of 0.16 μM for human 50 with an IC50 of 8 nM, also acts as a potent GPR55 agonist Nav1.7. with an EC50 of 39 nM.

Purity: 98.0% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

AM630 AMG 517 Cat. No.: HY-15421 Cat. No.: HY-10634

Bioactivity: AM630 is a selective CB2 antagonist with Ki of 31.2 nM, and Bioactivity: AMG 517 is a potent and selective vanilloid receptor-1 ( TRPV1) antagonist with an IC of 0.5 nM. displays 165-fold selectivity over CB 1 receptors. 50

Purity: 99.35% Purity: 99.87% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

www.MedChemExpress.com 15

AMG 579 AMG9810 Cat. No.: HY-12913 Cat. No.: HY-101736

Bioactivity: AMG 579 is a potent, selective, and efficacious inhibitor of Bioactivity: AMG9810 is a selective and competitive vanilloid receptor 1 (

phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. TRPV1) antagonist with IC50 values of 24.5 and 85.6 nM for human and rat TRPV1, repectively.

Purity: >98% Purity: 99.42% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Amibegron hydrochloride hydrochloride dihydrate (SR 58611A) Cat. No.: HY-103207 (MK-870 hydrochloride dihydrate) Cat. No.: HY-B0285B

Bioactivity: hydrochloride is a selective β3-adrenoceptor Bioactivity: Amiloride hydrochloride dihydrate is an inhibitor of both Epithelial sodium channel ( ENaC) and urokinase-type agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has and plasminogen activator receptor ( uTPA). antidepressant activity.

Purity: 99.0% Purity: 98.56% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg Size: 10mM x 1mL in DMSO, 100 mg

Amisulpride hydrochloride (DAN 2163) Cat. No.: HY-14545 (DAN 2163 hydrochloride) Cat. No.: HY-14545A

Bioactivity: Amisulpride is a dopamine D2/D3 receptor antagonist with Bioactivity: Amisulpride hydrochloride is a dopamine D2/D3 receptor

Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, antagonist with Kis of 2.8 and 3.2 nM for human dopamine

respectively. D2 and D3, respectively.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 200 mg, 500 mg 100 mg, 200 mg, 500 mg

Amitifadine hydrochloride hydrochloride (DOV-21947 hydrochloride; EB-1010 hydrochloride) Cat. No.: HY-18332A Cat. No.: HY-B0527A

Bioactivity: hydrochloride is a Bioactivity: Amitriptyline Hydrochloride is a serotonin-norepinephrine-dopamine (SNDRI), -derivative antidepressant (TCA).

with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

Purity: >98% Purity: 99.64% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 1 g, 5 g

Amoxapine AMP 397 (CL-67772) Cat. No.: HY-B0991 () Cat. No.: HY-15073

Bioactivity: is a antidepressant of the Bioactivity: AMP397 is the first competitive AMPA antagonist and an dibenzoxazepine family, though it is often classified as a antiepileptic agent. secondary amine .

Purity: 98.70% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 250 mg, 500 mg

16 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Ampalex AMPD2 inhibitor 1 (CX516; BDP 12; CX516) Cat. No.: HY-10933 Cat. No.: HY-103673

Bioactivity: Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and Bioactivity: AMPD2 inhibitor 1 is an deaminase 2 ( nootropic that acts as an AMPA receptor positive allosteric AMPD2) inhibitor, used in the research of sugar craving, modulator as a treatment for Alzheimer's disease, salt craving, umami craving, and addictions including drug, schizophrenia and mild cognitive impairment (MCI). , and alcohol addictions.

Purity: 91.0% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 10 mg, 50 mg, 100 mg, 200 mg

Amyloid beta-peptide(25-35) Amyloid β Peptide (42-1)(human) (Aβ25-35; β-Amyloid peptide(25-35)) Cat. No.: HY-P0128 Cat. No.: HY-P1362

Bioactivity: Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Bioactivity: Amyloid β Peptide (42-1)(human) is the inactive form of Alzheimer's amyloid β-peptide, has shown neurotoxic activities Amyloid β Peptide (1-42). Amyloid β Peptide (42-1) is a in cultured cells. Sequence: 42- peptide which plays a key role in the Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met. pathogenesis of Alzheimer disease. Sequence: Ala-Ile-Val-Val-G ly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp… Purity: 98.03% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg

Amyloid β-peptide (1-40) rat Amyloid β-Peptide (1-42) human Cat. No.: HY-P1387 (β-Amyloid (1-42), human) Cat. No.: HY-P1363

Bioactivity: Amyloid β-peptide (1-40) (rat) is the prone-to-aggregation Bioactivity: Amyloid β-Peptide (1-42) human is a 42-amino acid peptide product of amyloid precursor protein proteolytic cleavage, and which plays a key role in the pathogenesis of Alzheimer is the major constituent of senile plaques observed in the disease. Sequence: Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu brain of Alzheimer’s disease. Sequence: Asp-Ala-Glu-Phe-Gly-Hi -Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-A s-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-… sn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-… Purity: 95.06% Purity: 95.64% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 1 mg

Amyloid β-Protein 10-20 ANA-12 Cat. No.: HY-P1053 Cat. No.: HY-12497

Bioactivity: Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, Bioactivity: ANA-12 is a potent and selective TrkB antagonist, and binds maybe used in the research of neurological disease. ECD to TrkB -Fc with Kd of 12 μM.

Purity: >98% Purity: 99.30% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Anabasine Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)- ((S)-) Cat. No.: HY-B1532 (Androst-4-ene-3β,17β-diol, dipropionate) Cat. No.: HY-U00272

Bioactivity: Anabasine is a nicotinic receptor agonist. Bioactivity: Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)- is the dipropanoate of 4-Androstenediol, a metabolite of .

Purity: 98.71% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 17

Androsterone II (5α-Androstan-3α-ol-17-one) Cat. No.: HY-N0933 Cat. No.: HY-113012

Bioactivity: is a metabolic product of testosterone and can Bioactivity: Angiotensin II is a Vasoconstrictor that plays an endocrine activate Farnesoid X Receptor ( FXR). role in the regulation of pressure, fluid and homeostasis.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Size: 10mM x 1mL in DMSO, Size: 100 mg, 250 mg

Aniracetam (Ro 13-5057) Cat. No.: HY-10932 (6-Hydroxyhyoscyamine) Cat. No.: HY-N0584

Bioactivity: (Ro 13-5057) is a and neuroprotective Bioactivity: Anisodamine is an and α1-adrenergic receptor drug, which is selectively modulates the AMPA receptor and antagonist used in the treatment of acute circulatory , nAChR. is also a naturally occurring alkaloid found in some plants of the family.

Purity: 99.43% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 100 mg

Anle138b Ansofaxine hydrochloride Cat. No.: HY-101855 (LY03005; LPM570065) Cat. No.: HY-U00096

Bioactivity: Anle138b is a novel oligomer modulator. Bioactivity: Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and

norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg

Antazoline hydrochloride Anti- agent 1 (Phenazoline hydrochloride) Cat. No.: HY-B1067 Cat. No.: HY-U00314

Bioactivity: hydrochloride is a 1st generation Bioactivity: Anti-neurodegeneration agent 1 a neurodegeneration-targeting with also anticholinergic properties used to relieve nasal compound extracted from patent WO2008039514A1, Compound I. congestion and in eye drops.

Purity: 99.36% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

Anticonvulsant agent 1 Antihistamine-1 Cat. No.: HY-U00348 Cat. No.: HY-100238

Bioactivity: agent 1 is an anticonvulsant agent extracted Bioactivity: Antihistamine-1 is a H1-antihistamine ( Ki=6.9 nM) with from patent WO2001062726A2, Compound 156. acceptable blood-brain barrier penetration and also an

inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg

18 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

AP521 Apamin (Apamin (reduced), cyclic Cat. No.: HY-100166 (1→11),(3→15)-bis(disulfide); Apamine) Cat. No.: HY-P0256

Bioactivity: AP521 is an agonist of human 5-HT1A receptor with an IC50 Bioactivity: Apamin, an 18 amino acid peptide neurotoxin found in apitoxin 2+ + of 94 nM. (bee venom), is known to block Ca -activated K channels and prevent carbon tetrachloride-induced fibrosis. Sequence: Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gl n-Gln-His-NH2. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 500u g, 1 mg

Apimostinel (NRX-1074; AGN-241660) Cat. No.: HY-102053 (MK-0869; MK-869; L-754030) Cat. No.: HY-10052

Bioactivity: is an oral NMDA receptor . Bioactivity: Aprepitant (MK-0869) is a selective and high-affinity

neurokinin 1 receptor antagonist with a Kd of 86 pM.

Purity: >98% Purity: 99.93% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Apronal AR-08 (Allylisopropylacetylurea; Apronalide) Cat. No.: HY-B2177 Cat. No.: HY-U00371

Bioactivity: (Allylisopropylacetylurea, Apronalide) is a Bioactivity: AR-​08 is an agonist of α2-adrenergic receptor, used for the and drug that has been withdrawn in several countries treatment of attention deficit hyperactivety disorder (ADHD). due to side effects.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

AR-A 2 AR-M 1000390 hydrochloride (AR-A 000002) Cat. No.: HY-107018 Cat. No.: HY-101039A

Bioactivity: AR-A 2 is a selective 5-HT1B receptor antagonist, with high Bioactivity: AR-M 1000390 hydrochloride is an exceptionally selective, potent δ opioid receptor agonist with an EC50 of 7.2±0.9 affinity to guinea pig cortex 5HT1B/1D and recombinant nM for δ agonist . guinea pig 5-HT1B receptors ( Ki=0.24 and 0.47 nM) and with

10-fold lower affinity to guinea pig 5-HT1D receptor ( Ki Purity: >98% Purity: 99.80% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

AR7 ARA290 Cat. No.: HY-101106 (Cibinetide) Cat. No.: HY-P0168

Bioactivity: AR7 is a retinoic acid receptor α ( RARα) antagonist. Bioactivity: ARA290 is an EPO-derivative, acting as a specific agonist of /CD131 , and used for neurological disease treatment. Sequence: {Glp}-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser.

Purity: 98.77% Purity: 98.97% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg

www.MedChemExpress.com 19

Arecoline hydrobromide Argipressin ( ) Cat. No.: HY-B0489 (; Arg8-vasopressin; AVP) Cat. No.: HY-P0049

Bioactivity: Arecoline Hydrobromide is a muscarinic Bioactivity: Argipressin binds to the V1-vascular arginine vasopressin agonist. receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. Sequence: CysTyrPheGlnAsnCysProArgGly-NH2(Disulfide bridge: Cys1-Cys6).

Purity: 99.0% Purity: 99.66% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 500 mg, 1 g 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Arimoclomol maleate (BRX-220) Cat. No.: HY-106443A Cat. No.: HY-14546

Bioactivity: Arimoclomol maleate is a co-inducer of heat shock proteins ( Bioactivity: Aripiprazole(Abilify) is a human 5-HT1A receptor partial HSP). agonist with a Ki of 4.2 nM.

Purity: >98% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg, 1 g

ARN2966 hydrochloride Cat. No.: HY-18292 Cat. No.: HY-B0516

Bioactivity: ARN2966 is a potent post-transcriptional modulator of APP Bioactivity: Articaine Hydrochloride is a dental local anesthetic. expression; reduces expression of APP with resultant lower production of Aβ.

Purity: 98.39% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg

Asenapine hydrochloride (Org 5222) Cat. No.: HY-10121 Cat. No.: HY-16567

Bioactivity: Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, Bioactivity: Asenapine maleate, an antipsychotic, is a 5-HT (1A, 1B, 2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT 2B, , 5A, 6, 7) and Dopamine (D2, D3, D4) receptor receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 antagonist with K values of 0.03-4.0 nM for 5-HT and 1.3, nM. i 0.42, 1.1 nM for Dopamine receptor, respectively. Purity: >98% Purity: 99.39% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

Asenapine maleate Asiaticoside (Org 5222 maleate) Cat. No.: HY-11100 (Madecassol) Cat. No.: HY-N0439

Bioactivity: Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) Bioactivity: Asiaticoside, a trisaccaride triterpene from Centella asiatica,

and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, suppresses TGF-β/Smad signaling through inducing Smad7 and respectively, and an antipsychotic. inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties. Purity: 99.95% Purity: 98.46% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg 10 mg, 50 mg, 100 mg

20 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Astragaloside VI Astressin Cat. No.: HY-N6577 Cat. No.: HY-P0257

Bioactivity: Astragaloside VI could activate EGFR/ERK signalling pathway Bioactivity: Astressin is a potent corticotropin releasing factor ( CRF) to improve wound healing. antagonist. Sequence: d-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-NL E-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys- Leu-NLE-Glu-Ile-Ile-NH2.

Purity: 98.0% Purity: 96.98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg

Atenolol ((RS)-) Cat. No.: HY-17498 (MPV 1248) Cat. No.: HY-12380A

Bioactivity: Atenolol is a selective β1 receptor antagonist. Bioactivity: Atipamezole is a synthetic α2-adrenoceptor antagonist with a

Ki of 1.6 nM.

Purity: 98.0% Purity: 99.07% Clinical Data: Launched Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 10 mg, 50 mg

Atipamezole hydrochloride hydrochloride (Tomoxetine hydrochloride; LY (MPV-1248 hydrochloride) Cat. No.: HY-12380 139603; (R)-Tomoxetine hydrochloride) Cat. No.: HY-17385

Bioactivity: Atipamezole hydrochloride is a synthetic α2-adrenoceptor Bioactivity: Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and antagonist with a K of 1.6 nM. selective noradrenalin re-uptake inhibitor (Ki values are 5, i 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).

Purity: 99.96% Purity: 99.26% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 100 mg

ATP Atracurium besylate (Adenosine 5'-triphosphate) Cat. No.: HY-B2176 (BW-33A) Cat. No.: HY-B0292A

Bioactivity: ATP is a central component of energy storage and in Bioactivity: Atracurium Besylate is a neuromuscular blocking agent with vivo, provides the metabolic energy to drive metabolic pumps ED95 of 0.2 mg/kg. Target: nAChR Atracurium besylate is a and serves as a coenzyme in cells. neuromuscular-blocking drug or relaxant in the category of non-depolarizing neuromuscular-blocking , used adjunctively in anesthesia to facilitate endotracheal… Purity: 99.18% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 50 mg, 100 mg, 500 mg

Atropine sulfate (Tropine tropate; DL-) Cat. No.: HY-B1205 (Sulfatropinol) Cat. No.: HY-B1205A

Bioactivity: Atropine is a used to treat certain types of nerve Bioactivity: Atropine sulfate is a competitive muscarinic acetylcholine agent and pesticide poisonings, some types of slow heart rate, receptor antagonist. and to decrease saliva production during surgery.

Purity: 99.55% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg 100 mg

www.MedChemExpress.com 21

Atropine sulfate monohydrate Autocamtide 2 (Atropine sulfate hydrate) Cat. No.: HY-B0394 (Autocamtide II) Cat. No.: HY-P0225

Bioactivity: Atropine sulfate monohydrate is a competitive muscarinic Bioactivity: Autocamtide 2 is a highly selective peptide substrate of acetylcholine receptor antagonist. Target: mAChR Atropine is a calcium/calmodulin-dependent protein kinase II ( CaMKII). naturally occurring tropane alkaloid extracted from deadly It can be used in the CaMKII activity assay. Sequence: nightshade (), Jimson weed ( Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu. stramonium), mandrake ( officinarum) and other… Purity: 99.62% Purity: 98.17% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 100 mg

Autocamtide-2-related inhibitory peptide TFA Autophinib Cat. No.: HY-P0214A Cat. No.: HY-101920

Bioactivity: Autocamtide-2-related inhibitory peptide (TFA) is a highly Bioactivity: Autophinib is a potent autophagy inhibitor, which can inhibit

specific and potent inhibitor of CaMKII with an IC50 of 40 autophagy induced by starvation or rapamycin by targeting the kinase VPS34 with IC s of 90, 40 and 19 nM, nM. 50 respectively.

Purity: 98.48% Purity: 99.06% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

AVex-73 hydrochloride AVN-492 (AE-37 hydrochloride) Cat. No.: HY-101864 Cat. No.: HY-101924

Bioactivity: AVex-73 hydrochloride is a Sigma-1 Receptor agonist with Bioactivity: AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R ( K =91 pM). an IC50 of 860 nM. i

Purity: 99.72% Purity: 99.49% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

AWD 131-138 () Cat. No.: HY-14953 (γ-pipradol) Cat. No.: HY-B0530

Bioactivity: AWD 131-138(Imepitoin) is a new low-affinity partial Bioactivity: Azacyclonol, also known as γ-pipradol, is a drug used to receptor agonist with potent anticonvulsant and diminish in psychotic individuals. anxiolytic properties in rodent models.

Purity: 99.52% Purity: 99.35% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 g, 5 g

Azaperone Azaphen (Azafen; Pipofezin hydrochloride; Cat. No.: HY-B1470 hydrochloride) Cat. No.: HY-A0022

Bioactivity: acts as a but also has some Bioactivity: Pipofezine(Azafen or Azaphen) is a potent inhibitor of the antihistaminic and anticholinergic properties. Azaperone is a reuptake of serotonin. pyridinylpiperazine and neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. Purity: 99.58% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg 100 mg, 500 mg

22 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Azaphen dihydrochloride monohydrate (Azafen dihydrochloride hydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; …) Cat. No.: HY-A0022A (Y-25130 hydrochloride) Cat. No.: HY-B0068

Bioactivity: Pipofezine(Azafen or Azaphen) is a potent inhibitor of the Bioactivity: Azasetron HCl is a selective 5-HT3 receptor antagonist with reuptake of serotonin. IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer .

Purity: 99.60% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 100 mg, 500 mg 10 mg, 50 mg, 100 mg, 200 mg

AZD 9272 AZD-6280 Cat. No.: HY-110254 Cat. No.: HY-19872

Bioactivity: AZD 9272 is a brain penetrant mGluR5 antagonist. Bioactivity: AZD-6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized disorder.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

AZD-8529 AZD1080 Cat. No.: HY-107457 Cat. No.: HY-13862

Bioactivity: AZD-8529 is a potent, highly selective and orally bioavailable Bioactivity: AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 positive allosteric modulator of mGluR2, with an EC of 50 inhibits recombinant human GSK3α and GSK3β with pKi ( IC50) 285 nM, and shows no positive allosteric modulator responses of 8.2 (6.9 nM) and 7.5 (31 nM), respectively. at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

Purity: >98% Purity: 99.10% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

AZD1208 hydrochloride AZD2858 Cat. No.: HY-15604A Cat. No.: HY-15761

Bioactivity: AZD1208 hydrochloride is a novel, orally bioavailable, highly Bioactivity: AZD2858 is a potent, orally active GSK-3 inhibitor, with selective PIM kinases inhibitor. IC50s of 0.9 and 5 nM for GSK-3α and GSK-3β, respectively, used in the research of fracture healing.

Purity: >98% Purity: 99.24% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

AZD5904 Azeliragon Cat. No.: HY-111341 (TTP488) Cat. No.: HY-50682

Bioactivity: AZD5904 is a potent and irreversible inhibitor of human Bioactivity: TTP488 is an antagonist at the Receptor for Advanced Glycation

Myeloperoxidase ( MPO) with an IC50 of 140 nM and has End products, is evaluated as a potential treatment for similar potency in mouse and rat. patients with mild-to-moderate Alzheimer's disease (AD).

Purity: 98.0% Purity: 98.79% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

www.MedChemExpress.com 23

B-HT 920 BACE-IN-1 (Talipexole dihydrochloride) Cat. No.: HY-A0008 Cat. No.: HY-U00287

Bioactivity: B-HT 920( 2Hcl) is a dopamine D2 receptor agonist, Bioactivity: BACE-IN-1 (Compound 13) is a substituted lmidazo[1 α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which ,2-a]pyridine derivative which can inhibit β-site amyloid displays antiParkinsonian activity. IC50 Value: 25 precursor protein-cleaving (BACE) and that may be nM(Adrenergic receptor α-2, rat) Target: Adrenergic Receptor; useful in the treatment of diseases in which BACE is involved, 5-HT Receptor; Dopamine Receptor in vitro: N/A in vivo:… such as Alzheimer's disease. Purity: 99.99% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

BACE1-IN-1 Baclofen Cat. No.: HY-100182 Cat. No.: HY-B0007

Bioactivity: BACE1-IN-1 is a potent and highly brain penetrant BACE1 Bioactivity: Baclofen is a gamma-amino- (GABA) derivative used as a skeletal . Target: GABA Receptor Baclofen, inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. a lipophilic analog of gamma-aminobutyric acid, is clinically used to control spasticity. Baclofen pretreatment (3 mg/kg) not only prolonged the time taken for animals to reach a core… Purity: >98% Purity: 98.21% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 1 g, 5 g

Balipodect (TAK-063) Cat. No.: HY-12472 (RG7314; RO5028442) Cat. No.: HY-109024

Bioactivity: TAK-063 is a highly potent, selective and orally active PDE10A Bioactivity: Balovaptan is a highly potent and selective brain-penetrant

inhibitor with IC50 of 0.30 nM; >15000-fold selectivity vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and over other PDEs. IC50 value: 0.3 nM [1] Target: PDE10A 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used inhibitor TAK-063 has potent inhibitory activity (IC50 = 0.30 for the research of autism. nM), excellent selectivity (>15000-fold selectivity over… Purity: 98.04% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

BAM-22P BAN ORL 24 (Bovine adrenal medulla-22P) Cat. No.: HY-P1331 Cat. No.: HY-13222

Bioactivity: BAM-22P, a highly potent , is a potent opioid Bioactivity: BAN ORL 24 is a potent and selective NOP receptor antagonist. agonist. (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively).

Purity: >98% Purity: 95.07% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

BAR502 Cat. No.: HY-101273 (RG1662; RO5186582) Cat. No.: HY-16716

Bioactivity: BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of Bioactivity: Basmisanil is a highly selective GABAAα5 negative allosteric 2 μM and 0.4 μM, respectively. modulator.

Purity: 98.0% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

24 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Bavisant Bavisant dihydrochloride (JNJ-31001074) Cat. No.: HY-14880 Cat. No.: HY-14880A

Bioactivity: Bavisant (JNJ-31001074) is a highly selective, orally active Bioactivity: Bavisant Hcl (JNJ-31001074) is a highly selective, orally antagonist of the human H3 receptor with a novel mechanism of active antagonist of the human H3 receptor with a novel action, involving wakefulness and cognition, with potential as , involving wakefulness and cognition, with a treatment for ADHD. potential as a treatment for ADHD.

Purity: >98% Purity: >98% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

Bavisant dihydrochloride hydrate Bay 60-7550 (JNJ31001074AAC) Cat. No.: HY-14880B (BAY 607550) Cat. No.: HY-14992

Bioactivity: Bavisant Hcl hydrate(JNJ-31001074) is a highly selective, Bioactivity: Bay 60-7550 is a potent and selective PDE2 inhibitor with a orally active antagonist of the human H3 receptor with a novel Ki of 3.8 nM. mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.

Purity: 99.77% Purity: 98.12% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 100 mg

BAY 73-6691 BAY 73-6691 racemate ((R)-BAY 73-6691) Cat. No.: HY-104028 Cat. No.: HY-104028A

Bioactivity: BAY 73-6691 is a potent, selective brain penetrant PDE9A Bioactivity: BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor inhibitor. extracted from patent WO 2017070293 A1.

Purity: >98% Purity: 99.84% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

BD-1047 dihydrobromide BD-AcAc 2 Cat. No.: HY-16996A (Ketone Ester) Cat. No.: HY-15344

Bioactivity: BD-1047 dihydrobromide is a selective functional antagonist of Bioactivity: BD-AcAc 2, added in diet, could elevated mean blood ketone sigma receptors, shows antipsychotic activity in animal models bodies of 3.5 mm and lowered plasma glucose, , and predictive of in schizophrenia. in animals.

Purity: 98.0% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 100 mg, 500 mg

Beclamide Befetupitant (N-Benzyl-3-chloropropionamide) Cat. No.: HY-B1185 (Ro67-5930) Cat. No.: HY-19670

Bioactivity: is a drug that possesses anticonvulsant activity, Bioactivity: Befetupitant is a high-affinity, nonpeptide, competitive has been used as a sedative and as an anticonvulsant. tachykinin 1 receptor ( NK1R) antagonist.

Purity: 98.04% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

www.MedChemExpress.com 25

Befiradol (F 13640) Cat. No.: HY-14785 (3-Ethyl-3-methylglutarimide; Bemegrid) Cat. No.: HY-B1326

Bioactivity: (F13640) is a selective 5-HT1A receptor agonist. Bioactivity: Bemegride is a central nervous system stimulant and for poisoning.

Purity: >98% Purity: 99.91% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Benactyzine hydrochloride Bencianol Cat. No.: HY-B1542A (ZY15051) Cat. No.: HY-101573

Bioactivity: hydrochloride is a ( BChE) Bioactivity: Bencianol is a the semisynthetic flavinoid, with anti-spasmogenic activities. inhibitor with a Ki of 0.010 mM.

Purity: 98.74% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

Benfotiamine hydrochloride (S-Benzoylthiamine O-monophosphate) Cat. No.: HY-17374 (Serazide; Ro 4-4602) Cat. No.: HY-B0404A

Bioactivity: Benfotiamine is a synthetic S-acyl derivative of thiamine Bioactivity: Benserazide Hydrochloride is a peripherally-acting aromatic ( B1); an antioxidant dietary supplement. L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.

Purity: 99.58% Purity: 99.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 1 g, 5 g

Benzamide Derivative 1 Benzethonium chloride Cat. No.: HY-U00415 Cat. No.: HY-B0942

Bioactivity: Derivative 1 is a benzamide derivative from patent Bioactivity: Benzethonium chloride inhibit human recombinant α7 and α4β2 EP0213775A1, compound 18. Benzamide Derivative 1 may be useful neuronal nicotinic acetylcholine receptors in Xenopus oocytes. in treatment of gastrointestinal disorders.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg

Benzetimide hydrochloride (R4929) Cat. No.: HY-B1547A Cat. No.: HY-Y0258

Bioactivity: Benzetimide hydrochloride is a muscarinic acetylcholine Bioactivity: Benzocaine shares a common receptor with all other local receptor antagonist. (LAs) in the voltage-gated Na+ channel, with an

IC50 of 0.8 mM tested with a potential of +30 mV.

Purity: 99.44% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 g, 10 g

26 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Benztropine mesylate (Benzatropine mesylate; Benzotropine Beta-Amyloid(1-14),mouse,rat mesylate; Benztropine methanesulfonate) Cat. No.: HY-B0520A Cat. No.: HY-P1524

Bioactivity: Benzotropine is a centrally-acting, antimuscarinic agent used Bioactivity: Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of as an adjunct in the treatment of Parkinson's disease. Target: Amyloid-β peptide. mAChR Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease. It may also be used to treat extrapyramidal reactions, such as… Purity: 98.92% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg 1 g

Betahistine dihydrochloride Cat. No.: HY-B0524A (Carbamyl-β-methylcholine) Cat. No.: HY-B0406

Bioactivity: Dihydrochloride is a histamine H3 receptors Bioactivity: Bethanechol is a parasympathomimetic that inhibitor used as an antivertigo drug. selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Target: muscarinic receptor concentration dependently reduced muscle contractions, calcium mobilization, and epithelial secretion… Purity: 99.88% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 g 1 g, 5 g, 10 g

BF 227 BF-168 Cat. No.: HY-105252A Cat. No.: HY-112830

Bioactivity: BF 227 is a candidate for an amyloid imaging probe for PET, Bioactivity: BF-168, a candidate probe for PET, is found to specifically

with a Ki of 4.3 nM for Aβ1-42 fibrils. recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500 mg, 250 mg Size: 250 mg, 500 mg

BI-409306 BIA 10-2474 Cat. No.: HY-112831 Cat. No.: HY-19740

Bioactivity: BI-409306 is a potent and selective PDE9A inhibitor, with an Bioactivity: BIA 10-2474 is an inhibitor of fatty acid amide hydrolase ( FAAH) with IC values of 50 to 70mg/kg in various rat brain IC50 of 52 nM, and shows weak activity against other PDEs, 50 regions. such as PDE1A ( IC50, 1.4 µM), PDE1C ( IC50, 1.0 µM), PDE2A,

PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A ( IC50 all &… Purity: >98% Purity: 98.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Bilobalide ((-)-) Cat. No.: HY-N0076 (4-Methylgenistein; Olmelin) Cat. No.: HY-14595

Bioactivity: Bilobalide is a biologically active terpenic trilactone Bioactivity: Biochanin A is a naturally occurring fatty acid amide

present in Ginkgo biloba. An increasing number of studies have hydrolase ( FAAH) inhibitor, which inhibits FAAH with IC50s demonstrated its neuroprotective effects. IC50 Value: 3.33 of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, (pIC50 Value) [1] Target: neuroprotective in vitro: Inhibition respectively. by BB and GB was abolished in mutant receptors containing T6'S… Purity: 98.0% Purity: 98.86% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 200 mg, 500 mg

www.MedChemExpress.com 27

Biperiden Hydrochloride (KL 373) Cat. No.: HY-13204A (NSC 170950; NSC 84989) Cat. No.: HY-13204

Bioactivity: Biperiden(KL 373) is an antiparkinsonian agent, which is the Bioactivity: Biperiden(KL 373) Hcl is an antiparkinsonian agent, which is selective central M1 cholinoreceptors blocker. the selective central M1 cholinoreceptors blocker.

Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Bismuth Subsalicylate (Bismuth oxysalicylate; Bismuth(III) salicylate basic) Cat. No.: HY-B0550 (RG1678; RO4917838) Cat. No.: HY-10809

Bioactivity: Bismuth Subsalicylate is the active ingredient in Pepto-Bismol Bioactivity: Bitopertin is a potent, noncompetitive glycine reuptake and inhibits prostaglandin G/H Synthase 1/2. Target: Others inhibitor, inhibits glycine uptake at human GlyT1 with a Bismuth Subsalicylate reduces inflammation/irritation of concentration exhibiting IC50 of 25 nM. stomach and intestinal lining through inhibition of prostaglandin G/H Synthase 1/2 [1]. Bismuth Subsalicylate is… Purity: Purity: 99.75% Clinical Data: Launched Clinical Data: Phase 3 Size: 5 g, 10 g Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Bitopertin R enantiomer (RG1678 (R enantiomer); RO4917838 (R enantiomer)) Cat. No.: HY-10809A (AD-5423) Cat. No.: HY-13575

Bioactivity: Bitopertin is a potent, noncompetitive glycine reuptake Bioactivity: Blonanserin(AD-5423) is a D2/5-HT2 receptor antagonist, inhibitor, inhibits glycine uptake at human GlyT1 with a . Target: D2 receptor; 5-HT2 receptor concentration exhibiting IC50 of 25 nM. Blonanserin(AD-5423) is a relatively new atypical antipsychotic for the treatment of schizophrenia. Blonanserin belongs to a series of 4-phenyl-2-(1-piperazinyl)pyridines and… Purity: >98% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 25 mg, 100 mg 1 mg

BMS 299897 BMS 433796 Cat. No.: HY-50883 Cat. No.: HY-50884

Bioactivity: BMS 299897 is a γ-secretase inhibitor with an Bioactivity: BMS 433796 is a γ-secretase inhibitor with Aβ lowering

IC50 of 7 nM for Aβ production inhibition in HEK293 cells activity in a transgenic mouse model of Alzheimer's disease. stably overexpressing amyloid precursor protein (APP).

Purity: 99.35% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg

BMS-927711 BMT-145027 () Cat. No.: HY-15498 Cat. No.: HY-100728

Bioactivity: BMS-927711 is a highly potent, oral gene-related Bioactivity: BMT-145027 is an mGluR5 positive allosteric modulator

peptide ( CGRP) receptor antagonist with a Ki value of 0.027 without inherent agonist activity, exhibits an EC50 of 47 nM. nM.

Purity: 99.08% Purity: 98.0% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

28 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Bombesin BoNT-IN-1 Cat. No.: HY-P0195 Cat. No.: HY-18671

Bioactivity: is a tetradecapeptide originally isolated from frog Bioactivity: BoNT-IN-1 is a potent inhibitor of Botulinum neurotoxin A skin; plays an important role in the release of and light chain (BoNTA LC) with IC50 of 0.9 uM. the activation of G-protein receptors. Sequence: {Glp}-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2.

Purity: 99.69% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

BP 897 BPTU Cat. No.: HY-106660 (BMS-646786) Cat. No.: HY-13831

Bioactivity: BP 897 is a potent and selective dopamine D3 receptor Bioactivity: BPTU is a novel P2Y1 allosteric antagonist. agonist, and a weak dopamine D2 receptor antagonist, with

Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows

low affinities at D1 and D4 receptors ( Kis, 3 and 0.3… Purity: >98% Purity: 98.03% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

BQCA tosylate Cat. No.: HY-101858 Cat. No.: HY-12961A

Bioactivity: BQCA a highly selective allosteric modulator of the M1 Bioactivity: Bretylium (tosylate) is an inhibitor of the presynaptic mAChR. release of vasoconstrictor neurotransmitters.

Purity: 98.0% Purity: 98.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Brexpiprazole BRL-15572 dihydrochloride (OPC-34712) Cat. No.: HY-15780 (BRL-15572) Cat. No.: HY-13200

Bioactivity: is a partial agonist of human 5-HT1A and Bioactivity: BRL-15572 2Hcl is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. antagonist with a Ki of 0.47 nM. Purity: 99.38% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

BRL-50481 Cat. No.: HY-109586 Cat. No.: HY-13339

Bioactivity: BRL-50481 is a novel and selective inhibitor of PDE7 with Bioactivity: Brofaromine is a ( MAO) inhibitor with

IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 IC50 of 0.2μM for MAO-A. and PDE3, respectively.

Purity: 99.87% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 29

Bromisoval mesylate (Bromovalerylurea) Cat. No.: HY-B2113 (CB-154) Cat. No.: HY-12705A

Bioactivity: has anti-inflammatory effects and has been used as Bioactivity: Bromocriptine mesylate is a potent dopamine D2/D3 receptor an old sedative and hypnotic. agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

Purity: 99.94% Purity: 99.79% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 50 mg, 100 mg, 200 mg

Bromopride Cat. No.: HY-B1164 (R-11333) Cat. No.: HY-B0901

Bioactivity: is a dopamine antagonist with prokinetic Bioactivity: Bromperidol is a butyrophenone derivative, is a potent and properties widely used as an antiemetic. long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg Size: 50 mg, 100 mg

BT-11 Bulleyaconitine A Cat. No.: HY-102013 Cat. No.: HY-N0239

Bioactivity: BT-11 is an orally available LANCL2 binding compound for Bioactivity: Bulleyaconitine A is an and antiinflammatory drug treating inflammatory bowel disease. isolated from Aconitum plants; has several potential targets, including voltage-gated Na+ channels.

Purity: 98.60% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

Buspirone hydrochloride Cat. No.: HY-B1115 Cat. No.: HY-B1007

Bioactivity: hydrochloride is an anxiolytic psychotropic drug, is Bioactivity: Butacaine is a local anesthetic. used to treat generalized (GAD).

Purity: 99.64% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg 100 mg

Butamben Butylphthalide (Butyl 4-aminobenzoate) Cat. No.: HY-B1430 (3-n-Butylphthalide; 3-Butylphthalide) Cat. No.: HY-B0647

Bioactivity: is a long-duration local anesthetic used for the Bioactivity: Butylphthalide(3-n-Butylphthalide) is an treatment of . anti-cerebral-ischemia drug; first isolated from the seeds of celery, showed efficacy in animal models of .

Purity: 98.0% Purity: 99.98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g 10 mg, 50 mg

30 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

C-DIM12 CA-074 Cat. No.: HY-19808 Cat. No.: HY-103350

Bioactivity: C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA Bioactivity: CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to gene expression in cell lines and primary neurons. 5 nM.

Purity: 98.04% Purity: 98.92% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg 1 mg, 5 mg, 10 mg

CA-074 methyl ester Ca2+ channel agonist 1 (CA-074Me) Cat. No.: HY-100350 Cat. No.: HY-41076

Bioactivity: CA-074 methyl ester is a specific inhibitor of Cathepsin B, Bioactivity: Ca 2+ channel agonist 1 is an agonist of N-type Ca2+ channel which has potent bioactivities such as neuroprotective, and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 anti-cancer, and anti-inflamatory effects. μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. Purity: 98.40% Purity: 99.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg

Calcineurin substrate Calcitonin Gene Related Peptide (CGRP) (83-119), rat Cat. No.: HY-P0228 Cat. No.: HY-P1462

Bioactivity: Calcineurin substrate is a peptide from the regulatory RII Bioactivity: Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 subunit of cAMP-dependent protein kinase. It can be used in amino acid calcitonin family of , acts through the calcineurin activity assay. Sequence: Asp-Leu-Asp-Val-Pro- calcitonin receptor-like receptor ( CRLR). Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 500u g, 1 mg, 5 mg

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA Calmodulin-Dependent Protein Kinase II 290-309 Cat. No.: HY-P1462A Cat. No.: HY-P1479

Bioactivity: Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is Bioactivity: Calmodulin-Dependent Protein Kinase II (290-309) is a potent

a 37 amino acid calcitonin family of neuropeptide, acts CaMK antagonist with an IC50 of 52 nM for inhibition of Ca through calcitonin receptor-like receptor ( CRLR). 2+/calmodulin-dependent protein kinase II.

Purity: 96.21% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg

Camylofine Capromorelin Tartrate Cat. No.: HY-B1230 (CP 424391-18) Cat. No.: HY-15243

Bioactivity: is an antimuscarinic, is a smooth muscle relaxant. Bioactivity: Capromorelin Tartrate is an orally active, potent growth

secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a.

Purity: >98% Purity: 98.01% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 g Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg

www.MedChemExpress.com 31

Captopril Carabersat (SA333) Cat. No.: HY-B0368 Cat. No.: HY-U00307

Bioactivity: Captopril is a potent, competitive inhibitor of Bioactivity: Carabersat is a potent anticonvulsant agent. angiotensin-converting enzyme (ACE).

Purity: 98.05% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 500 mg

Carbamazepine Carbamic acid, N-[2,4-dimethyl-6-(4-morpholinyl)-3-pyridinyl]-, (CBZ; NSC 169864) Cat. No.: HY-B0246 phenylmethyl ester Cat. No.: HY-U00280 Bioactivity: , a , is an anticonvulsant Bioactivity: Carbamic acid, drug. Target: Sodium channel Carbamazepine inhibits the N-[2,4-dimethyl-6-(4-morpholinyl)-3-pyridinyl]-, phenylmethyl binding of [3H]batrachotoxinin A 20-α-benzoate (BTX-B) to a ester is a new invention for treating, one or more disorders receptor site of voltage-sensitive sodium channel with IC50 of or conditions wherein the dopaminergic system is disrupted, 131 μM, to decrease the activation of sodium channel ion flux… such as one or more disorders or conditions independently… Purity: 99.35% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 500 mg

Carbamoylcholine chloride (; Carbamylcholine chloride) Cat. No.: HY-B1208 ((S)-(-)-Carbidopa) Cat. No.: HY-B0311

Bioactivity: Carbamoylcholine chloride is used to study responses mediated Bioactivity: Carbidopa is an inhibitor of DOPA decarboxylase, which is used by nAChR and mAChR, including smooth , gut in parkinson disease. Target: DOPA decarboxylase Carbidopa motility, and neuronal signaling. IC50 value: 10 to 10,000 nM (CD), a competitive inhibitor of aromatic l-amino acid (Ki) Target: nAChR, mAChR Carbamoylcholine is an analog of decarboxylase that does not cross the blood-brain barrier, is acetylcholine that activates acetylcholine receptors (AChR).… routinely administered with levodopa (LD) to patients with… Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 10 mg, 50 mg

Carbinoxamine maleate salt Cat. No.: HY-B1589A (RGH 3331; Uxepam) Cat. No.: HY-U00241

Bioactivity: maleate salt is a histamine H1 receptor Bioactivity: Carburazepam is a drug which derives from benzodiazepine. antagonist. (BZD, BZs) are a class of psychoactive drugs whose core chemical structure is the fusion of a ring and a diazepine ring.

Purity: 99.78% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 500 mg

Cardamonin (Alpinetin chalcone; Cardamomin) Cat. No.: HY-N1378 (RGH-188) Cat. No.: HY-14763

Bioactivity: Cardamonin is a novel antagonist of hTRPA1 cation channel Bioactivity: Cariprazine is a novel antipsychotic drug candidate that

with an IC50 of 454 nM. exhibits high affinity for the D3 ( Ki=0.085 nM) and D2 (

Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A

receptor ( Ki=2.6 nM). Purity: 98.03% Purity: 98.01% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

32 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Cariprazine hydrochloride Catharanthine (RGH188 hydrochloride) Cat. No.: HY-14763A ((+)-3,4-Didehydrocoronaridine) Cat. No.: HY-N0252

Bioactivity: Cariprazine hydrochloride is a novel antipsychotic drug Bioactivity: Catharanthine inhibits nicotinic receptor mediated diaphragm

candidate that exhibits high affinity for the D3 ( Ki=0.085 contractions with IC50 of 59.6 μM.

nM) and D2 ( Ki=0.49 nM) receptors, and moderate affinity

for the 5-HT1A receptor ( Ki=2.6 nM). Purity: 99.89% Purity: 98.66% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 50 mg, 100 mg

CB-7921220 CB1 antagonist 1 Cat. No.: HY-101862 Cat. No.: HY-U00397

Bioactivity: CB-7921220 is an adenylate cyclase inhibitor. Bioactivity: CB1 antagonist 1 is an antagonist of CB1 receptor, used in the research of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and , gastrointestinal disorders, and cardiovascular conditions. Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg

CB1-IN-1 CB2R-IN-1 Cat. No.: HY-12790 Cat. No.: HY-100328

Bioactivity: CB1-IN-1 is a peripherally restricted CB1R antagonist, with Ki Bioactivity: CB2R-IN-1 is a potent cannabinoid CB2 receptor inverse of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, agonist with a K of 0.9 nM. respectively. i

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

CCG 203769 CDD0102 Cat. No.: HY-U00431 (CDD0102A) Cat. No.: HY-U00230

Bioactivity: CCG-203769 is a selective signaling ( RGS4) Bioactivity: CDD0102 is a potent M1 Muscarinic receptor agonist. inhibitor, which blocks the RGS4-Gα o protein-protein

interaction in vitro with an IC50 of 17 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

CDDD3602 CE-224535 (HGP6) Cat. No.: HY-U00203 (PF-04905428) Cat. No.: HY-15487

Bioactivity: CDDD3602 is a soft . Bioactivity: CE-224535 is a selective P2X7 receptor antagonist.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg

www.MedChemExpress.com 33

Cebranopadol (GRT6005) Cat. No.: HY-15536 (YKP3089) Cat. No.: HY-17607

Bioactivity: is an analgesic NOP and opioid receptor agonist Bioactivity: Cenobamate, a sodium channel blocker, enhances GABAergic

with Kis/ EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 transmission and has the potential to be a versatile CNS drug. nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively.

Purity: 98.24% Purity: 99.50% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Ceralifimod CERC-501 (ONO-4641) Cat. No.: HY-12685 (LY-2456302) Cat. No.: HY-101718

Bioactivity: Ceralifimod is selective, high potent agonist for sphingosine Bioactivity: LY-2456302 is a potent and centrally-penetrant kappa opioid 1-phosphate receptors 1 and 5, with EC s of 27.3, 334 pM 50 receptor antagonist with a Ki of 0.807 nM. for human S1P receptor 1 and 5, respectively.

Purity: >98% Purity: 99.24% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 20 mg

Cerebellin Cetrorelix Acetate Cat. No.: HY-P1544 (SB-075 acetate; NS-75A) Cat. No.: HY-P0009A

Bioactivity: Cerebellin is a neuromodulatory peptide widely distributed in Bioactivity: Cetrorelix Acetate is a potent gonadotropin-releasing hormone

the central nervous system. (GnRH) receptor antagonist with an IC50 of 1.21 nM. Sequence: N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg -Pro-Ala-NH2.

Purity: >98% Purity: 98.88% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Cevimeline Cevimeline hydrochloride Cat. No.: HY-70020 (AF-102B hydrochloride; SNI-2011 hydrochloride) Cat. No.: HY-70020B

Bioactivity: Cevimeline (Evoxac) is a parasympathomimetic and muscarinic Bioactivity: Cevimeline (Evoxac) Hcl is a parasympathomimetic and agonist, with particular effect on M3 receptors; used in the , with particular effect on M3 receptors; treatment of dry mouth associated with sjogren's syndrome. used in the treatment of dry mouth associated with sjogren's syndrome.

Purity: 90.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

Cevimeline hydrochloride hemihydrate CFM-2 Cat. No.: HY-76772 Cat. No.: HY-12503

Bioactivity: Cevimeline hydrochloride hemihydrate, a novel muscarinic Bioactivity: CFM-2 is a selective non-competitive AMPAR antagonist. receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

Purity: 98.0% Purity: 98.32% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 10 mg, 50 mg

34 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

CGP 25454A CGP-42112 Cat. No.: HY-100454 (CGP42112A) Cat. No.: HY-12405

Bioactivity: CGP 25454A is a novel and selective presynaptic dopamine Bioactivity: CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 antagonist. receptor(AT2 R) agonist. IC50 value: Target: AT2 R agonist in vitro: CGP42112 (>==1 nM) significantly inhibited cGMP production from the basal value. CGP42112 (>==1 nM) significantly inhibited TH-enzyme activity from the basal… Purity: 98.0% Purity: 98.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg 1 mg, 5 mg

CGP11952 CGP37157 Cat. No.: HY-U00192 Cat. No.: HY-15754

Bioactivity: CGP11952 is a triazolyl-Benzaphenon resembling the Bioactivity: CGP37157 is a potent, selective inhibitor of Na+/Ca2+ benzodiazepines in its pharmacological action. CGP11952 is an exchanger, inhibiting the Na +-induced Ca 2+-release from experimental benzodiazepine derivative. guinea-pig heart mitochondria, with an IC50 of 0.8 μM.

Purity: >98% Purity: 99.79% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

CGP52432 CGP71683 hydrochloride Cat. No.: HY-103531 (CGP71683A) Cat. No.: HY-107723

Bioactivity: CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 Bioactivity: CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a K of 1.3 nM, and shows no obvious nM. i

activity at Y1 receptor ( Ki, >4000 nM) and Y2 receptor (

Ki, 200 nM) in cell membranes. Purity: 98.50% Purity: 99.63% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

CGRP antagonist 1 CGS 21680 Cat. No.: HY-112262 Cat. No.: HY-13201

Bioactivity: CGRP antagonist 1 is a highly potent CGRP receptor Bioactivity: CGS 21680 is a specific adenosine A2A receptor agonist, used

antagonist with a Ki and IC50 of 35 and 57 nM, respectively. for treatment of neurological disease.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

CGS 21680 Hydrochloride Chembridge-5861528 Cat. No.: HY-13201A (TCS 5861528) Cat. No.: HY-15065

Bioactivity: CGS 21680 Hydrochloride is a specific adenosine A2A receptor Bioactivity: Chembridge-5861528 is a TRPA1 channel blocker that antagonizes agonist, used for treatment of neurological disease. AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).

Purity: 99.70% Purity: 97.04% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 35

CHF5074 (CSP-1103; Itanapraced) Cat. No.: HY-14399 (α-Chloralose) Cat. No.: HY-B1020

Bioactivity: CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Bioactivity: Chloralose is widely used in neuroscience and veterinary Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively. medicine as an anesthetic and sedative. IC50 value: 3.6 μM (Aβ42), 18.4 μM (Aβ40) [1] Target: γ-secretase in vitro: CHF5074 significantly reduces the area occupied by plaques and the number of plaques in cortex and… Purity: 98.05% Purity: 98.0% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 g

Chlormezanone Cat. No.: HY-B0353 Cat. No.: HY-B1607

Bioactivity: resembles benzodiazepine. The action of Bioactivity: Chlorphenoxamine is an antihistamine and anticholinergic used Chlormezanone is similar to benzodiazepine-type agents. as an antipruritic and antiparkinsonian agent. Chlormezanone is used as an anxiolytic and a muscle relaxant.

Purity: 99.85% Purity: 95.09% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg

Chlorpromazine hydrochloride Cat. No.: HY-B0407A Cat. No.: HY-B0274

Bioactivity: Hydrochloride is an antagonist of the Bioactivity: Chlorprothixene has strong binding affinities to dopamine and

dopamine D2 receptors, 5-HT2A receptors, potassium histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 channel, sodium channel, with K of 363 nM and 8.3 nM for and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, i 9.4 nM, 3 nM and 5.6 nM, respectively. dopamine D 2 receptor and serotonin 5-HT 2A recept… Purity: 99.83% Purity: 99.52% Clinical Data: Launched Clinical Data: Launched Size: 1 g, 5 g Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg

CI-943 ((±)-CI-943) Cat. No.: HY-100161 Cat. No.: HY-U00106

Bioactivity: CI-943 is a potential antipsychotic agent. Bioactivity: Cimetropium Bromide is a mAChR antagonist for long-term treatment of irritable bowel syndrome.

Purity: >98% Purity: 95.34% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 20 mg

Cinperene Cinromide (R5046) Cat. No.: HY-100265 (trans-3-Bromo-N-ethylcinnamamide) Cat. No.: HY-B1274

Bioactivity: Cinperene is an atropine-like drug which can block Bioactivity: Cinromide is a broad-spectrum anticonvulsant agent. -induced lacrimation and salivation.

Purity: >98% Purity: 99.87% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg

36 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Cipralisant (GT-2331) Cat. No.: HY-106993 (FUB-359) Cat. No.: HY-14567

Bioactivity: is a potent and selective histamine H3 Bioactivity: Ciproxifan(FUB-359) is a highly potent and selective histamin receptor antagonist in vivo, and an agonist in vitro, with a H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor; Cipralisant has entered in clinical trials for the treatment of attention-deficit hyperactivity… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 5 mg, 10 mg, 50 mg

Ciproxifan maleate CIQ (FUB 359 maleate) Cat. No.: HY-15289 Cat. No.: HY-18699

Bioactivity: Ciproxifan maleate(FUB-359 maleate) is a highly potent and Bioactivity: CIQ is a subunit-selective potentiator of NMDA receptors selective histamin H3-receptor antagonist with IC50 of 9.2 nM, containing the NR2C or NR2D subunit. with low apparent affinity at other receptor subtypes.

Purity: 99.56% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg

Cirsiliol Cirsimaritin Cat. No.: HY-110399 Cat. No.: HY-N6648

Bioactivity: Cirsiliol is a potent and selective 5-lipoxygenase inhibitor Bioactivity: Cirsimaritin binds weakly to the benzodiazepine site on

and a competitive low affinity benzodiazepine receptor ligand. GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg

Cisapride Cisatracurium besylate (R 51619; (±)-Cisaprid) Cat. No.: HY-14149 Cat. No.: HY-13596

Bioactivity: (R 51619) is a nonselective 5-HT4 receptor agonist, Bioactivity: Cisatracurium Besylate is a nondepolarizing neuromuscular it is also a potent hERG inhibitor. IC50 blocking agent, antagonizing the action of acetylcholine by Value: 0.14 μM(EC50 for 5-HT4 receptor) [1]; 9.8 μM (Kv4.3) inhibiting neuromuscular transmission. Target: AChR alpha-2 [2] Target: 5-HT4 Receptor in vitro: Cisapride showed higher Cisatracurium is a neuromuscular-blocking drug or skeletal inhibitory effects on a hERG current, as indicated by its IC50… muscle relaxant in the category of non-depolarizing… Purity: 99.72% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg 100 mg, 500 mg

Citalopram hydrobromide Citenamide ((±)- hydrobromide; Lu 10-171) Cat. No.: HY-B1287 (AY-15613; Cytenamide) Cat. No.: HY-101827

Bioactivity: Citalopram hydrobromide is an antidepressant drug of the Bioactivity: Citenamide is an anticonvulsant. selective serotonin reuptake inhibitor (SSRI) class. It has US FDA approval to treat major .

Purity: 99.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

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Citicoline (cytidine diphosphate-choline; CDP-Choline; sodium salt 5'-diphosphocholine) Cat. No.: HY-B0739 Cat. No.: HY-B0739A

Bioactivity: Citicoline is an intermediate in the synthesis of Bioactivity: Cytidoline sodium salt is an intermediate in the synthesis of , a component of cell membranes. Citicoline phosphatidylcholine which is a component of cell membranes and exerts neuroprotective effects. also exerts neuroprotective effects.

Purity: 99.90% Purity: 99.89% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in Water, 100 mg, 500 mg 100 mg, 500 mg

CL-275838 fumarate Cat. No.: HY-19146 (Meclastine fumarate) Cat. No.: HY-B0298A

Bioactivity: CL-275838 is a memory-enhancing agent, also with potent Bioactivity: Clemastine Fumarate is a selective histamine H1 receptor antidepressant activities. antagonist with IC50 of 3 nM. Target: Histamine H1 Receptor Clemastine Fumarate inhibits histamine induced rise in [Ca2+]i in HL-60 cells with an IC50 of 3 nM as compared with that of chlorpheniramine or with IC50 values of 20 nM… Purity: >98% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg

Clidinium bromide (Ro 2-3773) Cat. No.: HY-B1132 (Clocarpramine; 3-Chlorocarpipramine) Cat. No.: HY-B2073

Bioactivity: is an anticholinergic (specifically a Bioactivity: Clocapramine is an antagonist of the D2, 5-HT2A ) drug, may help symptoms of cramping and receptors. abdominal/stomach pain by decreasing stomach acid, and slowing the intestines.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 1 mg

Clomipramine hydrochloride Clothixamide Cat. No.: HY-B0457 (Clotixamide) Cat. No.: HY-U00021

Bioactivity: HCl is a (SERT), Bioactivity: Clothixamide is a derivative. It is used to treat norepinephrine transporter (NET) (DAT) psychiatric disorders. blocker with Ki of 0.14, 54 and 3 nM, respectively. Target: 5-HT Receptor Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin… Purity: 99.72% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 500 mg

Clozapine N-oxide (HF 1854) Cat. No.: HY-14539 Cat. No.: HY-17366

Bioactivity: Clozapine (HF 1854) is an antipsychotic used to treat Bioactivity: Clozapine N-oxide (CNO) is a major metabolite of the schizophrenia. Clozapine is a potent antagonist of dopamine anti-psychotic drug clozapine. Clozapine N-oxide is a agonist

and a number of other receptors, with a Ki of 9.5 nM for M1 for the chemogenetic Designer Receptors Exclusively Activated receptor. by Designer Drug ( DREADD) system.

Purity: 99.97% Purity: 99.63% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg, 5 g 5 mg, 10 mg, 50 mg, 100 mg

38 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

CM-4620 CMPDA Cat. No.: HY-101942 Cat. No.: HY-12508

Bioactivity: CM-4620 is a calcium-release activated calcium-channel (CRAC) Bioactivity: CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o inhibitor, with IC50s of 119, 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively. receptor.

Purity: 99.94% Purity: 97.19% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg

CNQX CNV1014802 (FG9065) Cat. No.: HY-15066 (GSK-1014802; Raxatrigine) Cat. No.: HY-12796

Bioactivity: CNQX (FG9065) is a potent AMPA/kainate receptor antagonist. Bioactivity: CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

Purity: 98.05% Purity: 99.47% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

CNV1014802 hydrochloride (GSK-1014802 hydrochloride; Raxatrigine hydrochloride) Cat. No.: HY-12796A (Ubiquinone-10; CoQ10) Cat. No.: HY-N0111

Bioactivity: CNV1014802(GSK-1014802) Hcl is a novel small molecule Bioactivity: Coenzyme Q10 is an essential cofactor of the electron state-dependent sodium channel blocker; Nav1.7 sodium channel transport chain and a potent antioxidant agent. inhibitor.

Purity: 98.69% Purity: 98.0% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 200 mg, 500 mg, 1 g, 5 g

Colivelin Colivelin TFA Cat. No.: HY-P1061 Cat. No.: HY-P1061A

Bioactivity: Colivelin is a neuroprotective peptide and activator of Bioactivity: Colivelin (TFA) is a neuroprotective peptide and activator of STAT3. STAT3.

Purity: >98% Purity: 95.29% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg Size: 500u g, 1 mg

Coluracetam Conduritol B epoxide (MKC-231) Cat. No.: HY-17553 Cat. No.: HY-100944

Bioactivity: (MKC-231) is a new choline uptake enhancer. IC50 Bioactivity: Conduritol B epoxide is an irreversible covalently bound acid

value: Target: in vitro: MKC-231 (10(-10)-10(-6) moll) β-glucosidase (GCase) inhibitor, with IC50s of 1 and 100 μM significantly increased high affinity choline uptake (HACU) for β-glucosidase and α-glucosidase respectively. when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but… Purity: 99.77% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg

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Corticosterone (17-Deoxycortisol; Corticotropin-releasing factor human 11β,21-Dihydroxyprogesterone; Kendall's compound B) Cat. No.: HY-B1618 (Human CRF; Human corticotropin-releasing factor) Cat. No.: HY-P0086

Bioactivity: Corticosterone is a sensitive inhibitor of monoamine Bioactivity: Corticotropin-releasing factor (CRF) (human) stimulates the transport. Target: OCT(organic cation transporter) synthesis and secretion of adrenocorticotropin in the anterior Corticosterone is a 21-carbon hormone of the pituitary. Sequence: Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-T type produced in the cortex of the adrenal hr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln glands in rodents and other non-human animals. Corticosterone… -Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Il… Purity: 99.29% Purity: 98.20% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250u g, 500u g, 1 mg, 5 mg, 10 mg 50 mg

Corydaline CP 316311 ((+)-; Corydalin) Cat. No.: HY-N0923 Cat. No.: HY-14129

Bioactivity: Corydaline is an acetylcholinesterase inhibitor isolated from Bioactivity: CP 316311 is a potent and selective CRF1 receptor antagonist Corydalis yanhusuo. with an IC50 value of 6.8 nM.

Purity: 98.17% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg

CP 376395 CP-409092 (CP-316311) Cat. No.: HY-14130 Cat. No.: HY-101639

Bioactivity: CP 376395 is a potent and selective Corticotropin releasing Bioactivity: CP-409092 is a GABA(A) partial agonist, used for the factor 1 (CRF1) receptor antagonist. treatment of anxiety.

Purity: 99.53% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

CP-809101 CP-809101 hydrochloride Cat. No.: HY-15543 Cat. No.: HY-15543A

Bioactivity: CP-809101 is a potent and selective 5-HT2C receptor agonist Bioactivity: CP-809101 Hcl is a potent and selective 5-HT2C receptor with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A agonist with pEC50 of 9.96/7.19/6.81 for human receptors respectively. 5-HT2C/5-HT2B/5-HT2A receptors respectively.

Purity: >98% Purity: 99.38% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

CPPHA Cresyl Violet acetate Cat. No.: HY-14612 Cat. No.: HY-101888

Bioactivity: CPPHA is a selective positive allosteric modulator of mGluR5 Bioactivity: Cresyl violet acetate is a red fluorescent stain, which can be receptor. used to stain neurons.

Purity: 97.93% Purity: 70.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg 5 mg, 10 mg, 50 mg

40 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Cresyl Violet perchlorate Crustacean Cardioactive Peptide CCAP (Oxazine 9 perchlorate) Cat. No.: HY-101889 Cat. No.: HY-P0303

Bioactivity: Cresyl Violet perchlorate is a red fluorescent stain, which Bioactivity: Crustacean Cardioactive Peptide (CCAP) is a highly conserved, can be used to stain neurons. amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardioactive Peptide (CCAP) also modulates the neuronal activity in other… Purity: >98% Purity: 98.91% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 50 mg Size: 1 mg, 5 mg, 10 mg

CTEP CX-157 (mGluR5 inhibitor) Cat. No.: HY-15445 Cat. No.: HY-100178

Bioactivity: CTEP is a novel, long-acting, orally bioavailable allosteric Bioactivity: CX-157 is a reversible inhibitor of monoamine oxidase-A ( antagonist of mGlu5 receptor with MAO-A) with an EC50 of 19.3ng/mL. IC50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors.

Purity: 97.49% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

CX546 Cyclo(his-pro) (Cyclo(histidyl-); Histidylproline Cat. No.: HY-12505 diketopiperazine) Cat. No.: HY-101402

Bioactivity: CX546 is a selective positive AMPAR modulator; the Bioactivity: Cyclo(His-Pro) is a cyclic dipeptide structurally related to prototypical ampakine agent. IC50 value: Target: AMPAR agonist tyreotropin-releasing hormone. Cyclo(His-Pro) could inhibit in vitro: Treatments with the ampakine CX614 markedly and NF-κB nuclear accumulation. reversibly increased brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal… Purity: 99.50% Purity: 99.41% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg 25 mg, 50 mg, 100 mg

Cyclobenzaprine hydrochloride Cyclodrine hydrochloride (MK130 hydrochloride) Cat. No.: HY-B0740 Cat. No.: HY-U00139

Bioactivity: Hcl is a skeletal muscle relaxant and a Bioactivity: Cyclodrine hydrochloride is a (muscarinic, central nervous system (CNS) . nicotinic) ( mAChR and nAChR) receptor antagonist.

Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g, 5 g

Cyproheptadine hydrochloride hydrochloride sesquihydrate Cat. No.: HY-B0366A Cat. No.: HY-B1165

Bioactivity: Cyproheptadine is a antagonist for 5-HT2 Bioactivity: Cyproheptadine hydrochloride sesquihydrate is an antihistamine receptor with IC50 of 0.6 nM. and is an antagonist of serotonin and histamine2.

Purity: 98.96% Purity: 99.20% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg, 1 g 100 mg

www.MedChemExpress.com 41

CYR-101 Cyromazine (MIN-101; MT-210) Cat. No.: HY-19469 (Cyromazin; CGA-72662) Cat. No.: HY-B1331

Bioactivity: MIN-101 is a novel cyclic amide derivative that has high Bioactivity: Cyromazine is a triazine insect growth regulator used as an

equipotent affinities for 5-HT2A and sigma-2 receptors ( insecticide and an acaricide. It is a cyclopropyl derivative K of 7.53 nM and 8.19 nM for 5-HT and sigma-2, of . Cyromazine works by affecting the nervous system i 2A of the immature larval stages of certain insects. respectively). Purity: 98.26% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg

CZC-25146 CZC-25146 hydrochloride Cat. No.: HY-15800A Cat. No.: HY-15800

Bioactivity: CZC-25146 is a potent, selective and metabolically stable Bioactivity: CZC-25146 Hcl is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively. IC50 value: 4.76 nM/6.87 LRRK2 and G2019S LRRK2 respectively. IC50 value: 4.76 nM/6.87 nM(wild type/G2019S LRRK2) [1] Target: LRRK2 nM(wild type/G2019S LRRK2) [1] Target: LRRK2 CZC-25146displayed a very clean profile, it inhibited only… CZC-25146displayed a very clean profile, it inhibited only… Purity: 98.24% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 50 mg 10 mg, 100 mg

CZC-54252 D-AP5 Cat. No.: HY-B0792 (D-APV; D-2-Amino-5-phosphonovaleric acid) Cat. No.: HY-100714A

Bioactivity: CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM Bioactivity: D-AP5 is a NMDA receptor antagonist. and 1.85 nM for wild-type and G2019S LRRK2 respectively. IC50 value: 1.28 nM/1.85 nM(LRRK2/G2019S LRRK2) [1] Target: LRRK2 inhibitor in vitro: CZC-54252 inhibited the activity of recombinant human wild-type LRRK2 with an IC50 ranging from 1… Purity: 99.26% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg

D-Arabitol D-Galactose Cat. No.: HY-N3686 (D-(+)-Galactose) Cat. No.: HY-N0210

Bioactivity: Arabinitol, D- is a polyol and its accumulation may cause a Bioactivity: D-Galactose is a natural aldohexose and C-4 epimer of glucose. neurotoxic effect in human.

Purity: >98% Purity: 98.0% Clinical Data: Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 1 g 500 mg, 5 g

D-Glutamic acid DAA-1106 ((R)-Glutamic acid) Cat. No.: HY-100805 Cat. No.: HY-19945

Bioactivity: D-glutamic acid, an enantiomer of L- glutamic acid, is widely Bioactivity: DAA1106 is a potent and selective ligand for peripheral used in pharmaceuticals and foods. benzodiazepine receptor (PBR), as a potent and selective agonist at the peripheral benzodiazepine receptor. Target:PBR in vitro: DAA1106 binding to PBR was significantly increased in widespread areas in MCI subjects when compared to healthy… Purity: 99.30% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 g, 10 g 2 mg, 5 mg, 10 mg, 25 mg, 50 mg

42 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Dapoxetine hydrochloride DAPT (LY-210448 hydrochloride) Cat. No.: HY-B0304A (GSI-IX) Cat. No.: HY-13027

Bioactivity: HCl is a short-acting novel selective serotonin Bioactivity: DAPT is a γ-secretase inhibitor with IC50s of 115 and 200 nM reuptake inhibitor(SSRI). for total Aβ and Aβ42, respectively.

Purity: 99.85% Purity: 99.97% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

Darenzepine Cat. No.: HY-100154 (UK-88525) Cat. No.: HY-A0033

Bioactivity: Darenzepine is a muscarinic receptor inhibitor extracted Bioactivity: Darifenacin(UK88525) is a selective M3 muscarinic receptor from patent US 20170095465 A1. antagonist with pKi of 8.9. IC50 value: 8.9 (pKi) [1] Target: M3 receptor in vitro: Darifenacin exerts non-parallel rightward displacement of the agonist curve and also significant depression of the maximum response… Purity: >98% Purity: 97.38% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 10 mg

Darifenacin hydrobromide Cat. No.: HY-A0012 (PY 108-068; PY-108068) Cat. No.: HY-U00086

Bioactivity: Darifenacin HBr(UK88525) is a selective M3 muscarinic receptor Bioactivity: Darodipine (PY 108-068, PY-108068) is a potent calcium antagonist with pKi of 8.9. channel antagonist.

Purity: 95.14% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 10 mg, 100 mg

Dasotraline hydrochloride (SEP 225289) Cat. No.: HY-12850 (SEP-225289 hydrochloride) Cat. No.: HY-12850A

Bioactivity: Dasotraline is a triple reuptake inhibitor that blocks Bioactivity: Dasotraline hydrochloride (SEP-225289 hydrochloride) is a dopamine, norepinephrine, and serotonin transporters with triple reuptake inhibitor that blocks dopamine,

IC50 values of 4, 6, and 11 nM, respectively. norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

Purity: >98% Purity: 99.60% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Decamethonium Bromide Dehydroascorbic acid Cat. No.: HY-B0570 Cat. No.: HY-110281

Bioactivity: Bromide is a nicotinic AChR partial agonist and Bioactivity: Dehydroascorbic acid, a blood-brain barrier transportable form neuromuscular blocking agent. of , mediates potent cerebroprotection in experimental stroke.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Size: 10mM x 1mL in DMSO, Size: 5 g, 10 g

www.MedChemExpress.com 43

Deltorphin 2 I ([D-Ala2]-Deltorphin II) Cat. No.: HY-P1013 (Deltorphin 1; Deltorphin C) Cat. No.: HY-P1336

Bioactivity: Deltorphin 2 is a selective peptide agonist for the δ opioid Bioactivity: is a δ-opioid receptor agonist with high affinity receptor. and selectivity.

Purity: 98.20% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 25 mg

Dencichin (Dencichine; L-Dencichin; ODAP) Cat. No.: HY-N1477 (EGIS-3886) Cat. No.: HY-101630

Bioactivity: Dencichin is a non-protein amino acid originally extracted Bioactivity: Deramciclane has a high affinity for 5-HT2A and 5-HT2C from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 receptors; it acts as an antagonist at both receptor subtypes (PHD-2) activity. and has properties at the 5-HT 2C receptors without direct stimulatory agonist. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Dermorphin hydrochloride Cat. No.: HY-P0244 (Deformylflustrabromine hydrochloride; dFBr hydrochloride) Cat. No.: HY-107675

Bioactivity: is a natural heptapeptide μ-opioid receptor ( Bioactivity: Desformylflustrabromine hydrochloride is a selective agonist

MOR) agonist found in amphibian skin. Sequence: of α4β2 neuronal nicotinic acetylcholine receptor ( nAChR) Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. with a pEC50 of 6.48.

Purity: >98% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Desipramine hydrochloride Cat. No.: HY-B1272 (O-Desmethylvenlafaxine) Cat. No.: HY-B0602

Bioactivity: hydrochloride is an inhibitor of norepinephrine Bioactivity: Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) transporter ( NET), 5-HT transporter ( SERT) and reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. dopamine transporter ( DAT) with Kis of 4, 61 and 78,720 nM, respectively.

Purity: 99.68% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg

Desvenlafaxine succinate hydrate (O-Desmethylvenlafaxine succinate hydrate) Cat. No.: HY-B0602A Cat. No.: HY-B0163

Bioactivity: Desvenlafaxine succinate hydrate is an antidepressant of the Bioactivity: Detomidine produce dose-dependent sedative and analgesic serotonin-norepinephrine reuptake inhibitor (SNRI). effects, is a nonnarcotic, synthetic α2-

Purity: 98.25% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 10 mg, 50 mg

44 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Detomidine hydrochloride hydrochloride ((+)- Cat. No.: HY-B0163A hydrochloride; (S)-Medetomidine hydrochloride) Cat. No.: HY-17034A

Bioactivity: Detomidine hydrochloride produce dose-dependent sedative and Bioactivity: Dexmedetomidine Hydrochloride is an agonist of adrenergic analgesic effects, is a nonnarcotic, synthetic α2-adrenergic alpha-2 receptor, which is used in veterinary medicine for its agonist analgesic and sedative properties. Target: Adrenergic alpha-2 Receptor Dexmedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease… Purity: 99.80% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

Dexpramipexole Dexpramipexole dihydrochloride ((R)-; R-(+)-Pramipexole; KNS-760704) Cat. No.: HY-17355B ((R)-Pramipexole dihydrochloride; KNS 760704; SND 919CL2X)Cat. No.: HY-17355A

Bioactivity: Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, Bioactivity: Dexpramipexole 2Hcl(KNS-760704), also known as is a neuroprotective agent and weak non- dopamine R-(+)-Pramipexole, is a neuroprotective agent and weak agonist. IC50 Value: non-ergoline .

Purity: >98% Purity: 98.01% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

DHBP dibromide Dibucaine (Diheptylviologen dibromide) Cat. No.: HY-101237 () Cat. No.: HY-B0552

Bioactivity: DHBP dibromide is an inhibitor for calcium release and a Bioactivity: Dibucaine is a local anesthetic of the amide type now muscle relaxant. generally used for surface anesthesia.

Purity: 99.56% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 g, 10 g

Dibucaine hydrochloride Dichlorphenamide (Cinchocaine hydrochloride) Cat. No.: HY-B0552A (Diclofenamide) Cat. No.: HY-B0397

Bioactivity: Dibucaine Hydrochloride is a local anesthetic of the amide Bioactivity: Dichlorphenamide(Diclofenamide) is a carbonic anhydrase type now generally used for surface anesthesia. inhibitor that is used in the treatment of glaucoma.

Purity: 99.67% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g, 10 g 10 mg, 50 mg, 100 mg

Diclofensine hydrochloride (Ro 8-4650) Cat. No.: HY-18610A (Ro 8-4650 hydrochloride) Cat. No.: HY-18610

Bioactivity: Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine Bioactivity: Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. 2.3, and 3.7 nM, respectively.

Purity: >98% Purity: 96.44% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg

www.MedChemExpress.com 45

Dihexa (PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic mesylate amide; Hexanoyl-Tyr-Ile-Ahx-NH2) Cat. No.: HY-16969 Cat. No.: HY-B0670A

Bioactivity: is an orally active, blood-brain barrier-permeable Bioactivity: Dihydroergotamine mesylate is an ergot alkaloid used to treat angiotensin IV analog; exhibits high affinity binding migraines.

hepatocyte ( HGF) with a Kd of 65 pM.

Purity: 98.0% Purity: 99.91% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg

Dihydroergotoxine mesylate phosphate ( mesylates) Cat. No.: HY-B0799 Cat. No.: HY-B2215

Bioactivity: Dihydroergotoxine mesylate is a complex of closely related Bioactivity: Dimemorfan phosphate is a sigma 1 receptor agonist, used alkaloid salts; Binds with high affinity to the GABAA receptor as a potent antitussive. Cl- channel, producing an allosteric interaction with the benzodiazepine site. IC50 value: Target: Dihydroergotoxine mesylate also interacts with central dopaminergic,… Purity: 98.0% Purity: 98.42% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg, 100 mg

Dimenhydrinate Cat. No.: HY-B1215 (Dimethacrine) Cat. No.: HY-B2075

Bioactivity: is an anti-emetic and anti-histamine commonly Bioactivity: Dimetacrine is a useful antidepressant which can be used for available over-the-counter as a motion sickness remedy. the treatment of various types of depression.

Purity: 99.89% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 100 mg

Diperodon hydrochloride Diphenidol hydrochloride Cat. No.: HY-B1226 (Difenidol hydrochloride) Cat. No.: HY-A0082

Bioactivity: Diperodon is a local anaesthetics, by the action of hydrolazes Bioactivity: Diphenidol hydrochloride is a muscarinic antagonist employed in blood serum is decomposed. as an antiemetic and as an antivertigo agent.

Purity: >98% Purity: 99.60% Clinical Data: No Development Reported Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 100 mg

Diphenyleneiodonium chloride hydrochloride (DPI) Cat. No.: HY-100965 (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) Cat. No.: HY-B0970

Bioactivity: Diphenyleneiodonium chloride is a NADPH oxidase ( NOX) Bioactivity: Diphenylpyraline Hcl is a first-generation antihistamine with inhibitor and also functions as a TRPA1 activator with an anticholinergic effects, acts as a dopamine reuptake inhibitor, shows to be useful in the treatment of EC50 of 1 to 3 μM. .

Purity: 99.87% Purity: 99.02% Clinical Data: Phase 4 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg 1 g

46 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Dipraglurant (ADX48621) Cat. No.: HY-14859 Cat. No.: HY-U00153

Bioactivity: (ADX 48621) is a mGluR5 antagonists with IC50 of Bioactivity: Dixyrazine, a phenothiazine derivative, can prevent brain 0.021 μM. oedema induced by intracarotid injection of protamine sulphate.

Purity: 99.50% Purity: 99.87% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 20 mg

DL-Epinephrine DMP 696 ((±)-Epinephrine; (±)-; DL-Adrenali) Cat. No.: HY-B0447 Cat. No.: HY-12131

Bioactivity: DL-Epinephrine is the racemate of epinephrine. L-Epinephrine Bioactivity: DMP 696 is a selective corticotropin-releasing hormone is a hormone secreted by the medulla of the adrenal glands. receptor 1 (CRHR1) antagonist, used for the treatment of L-Epinephrine is an α-adrenergic and β-adrenergic receptor anxiety and depression. agonist.

Purity: 99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 g, 5 g Size: 1 mg, 5 mg, 10 mg, 20 mg

DO-264 Docosahexaenoic Acid Cat. No.: HY-114157 (DHA; Cervonic Acid) Cat. No.: HY-B2167

Bioactivity: DO-264 is a selective and in vivo-active inhibitor of Bioactivity: Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly

Abhydrolase Domain Containing 12 ( ABHD12), with an IC50 of present brain and retina. It can be obtained directly from 11 nM. fish oil and maternal milk.

Purity: >98% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg

Docosahexaenoic Acid methyl ester (all cis-DHA methyl ester; Methyl docosahexaenoate) Cat. No.: HY-101541 (R33812) Cat. No.: HY-B0411

Bioactivity: Docosahexaenoic Acid methyl ester is a methylated Bioactivity: Domperidone is a dopamine blocker and an antidopaminergic docosahexaenoic acid analog which can be intercalated into reagent. membrane phospholipids without being oxidized or hydrolyzed.

Purity: 95.0% Purity: 99.52% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg 100 mg, 200 mg, 500 mg

Donepezil Hydrochloride (E2020) Cat. No.: HY-14566 (E2020) Cat. No.: HY-B0034

Bioactivity: Donepezil(E 2020) is a specific and potent AChE inhibitor for Bioactivity: Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, inhibitor, which can readily cross the blood brain barrier and respectively. Target: AChE Donepezil is a specific and potent increases the concentration of cortical acetylcholine. AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively [1]. Donepezil inhibits the… Purity: 99.87% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 50 mg, 100 mg, 200 mg

www.MedChemExpress.com 47

Dopamine hydrochloride Dopamine serotonin antagonist-1 (ASL279) Cat. No.: HY-B0451A Cat. No.: HY-42110

Bioactivity: Dopamine HCl is a neurotransmitter present in a Bioactivity: Dopamine serotonin antagonist-1 is a dual dopamine and wide variety of animals,And a dopamine D1-5 receptors agonist. serotonin receptor antagonist with Kis of 200, 2500, 420, 39, Target: Dopamine Receptor Dopamine (or 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, 3,4-dihydroxyphenethylamine) is a neuroendocrine transmitter respectively. in the catecholamine and families that plays a… Purity: 98.0% Purity: 99.79% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 10 mg, 50 mg, 100 mg

Doxapram hydrochloride hydrate Cat. No.: HY-B0551 Cat. No.: HY-B0551A

Bioactivity: Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric Bioactivity: Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, channel function with EC50 of 410 nM, 37 μM, 9 μM, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 respectively. nM, 37 μM, 9 μM, respectively.

Purity: >98% Purity: 98.86% Clinical Data: Launched Clinical Data: Launched Size: 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg

Doxepin Hydrochloride DPN Cat. No.: HY-B0725 (Diarylpropionitrile) Cat. No.: HY-12452

Bioactivity: HCl is a tricyclic antidepressant that is marketed Bioactivity: Diarylpropionitrile(DPN) is a non-steroidal estrogen receptor worldwide. β(ER β) selective ligand.

Purity: 99.41% Purity: 99.66% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g, 10 g 5 mg, 10 mg

DPP-IV-IN-2 DREADD agonist 21 Cat. No.: HY-108319 Cat. No.: HY-100234

Bioactivity: DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV ( Bioactivity: DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors ( hM3Dq) agonist( EC =1.7 nM). DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively. 50

Purity: 98.0% Purity: 98.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 2 mg, 5 mg, 10 mg

Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) Cat. No.: HY-B1239 (Dehydrobenzperidol) Cat. No.: HY-B1240

Bioactivity: hydrochloride is a potent competitive inhibitor of Bioactivity: Droperidol is a Dopamine-2 Receptor Antagonist. BChE, and the ki values of Drofenine is calculated to be 3 uM. IC50 value: 3 uM (ki) Target: BChE Benactyzine is widely used anticholinergic drugs, acts on smooth muscle to stop muscle . Purity: 98.10% Purity: 99.29% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 100 mg

48 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Droxidopa (L-DOPS; DOPS; SM5688) Cat. No.: HY-13458 ((S)-Duloxetine; LY248686) Cat. No.: HY-B0161

Bioactivity: (L-DOPS, SM5688) is a synthetic amino acid precursor Bioactivity: Duloxetine is a serotonin-norepinephrine reuptake inhibitor which acts as a to the neurotransmitters with Ki of 4.6 nM, used for treatment of major depressive norepinephrine (noradrenaline) and epinephrine (adrenaline); disorder and generalized anxiety disorder (GAD). capable of crossing the protective blood–brain barrier IC50 value: Target: The acute administration of droxidopa in PVL… Purity: 99.58% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 500 mg Size: 10 mg, 50 mg

Duloxetine hydrochloride Duoperone ((S)-Duloxetine hydrochloride; LY-248686 hydrochloride) Cat. No.: HY-B0161A Cat. No.: HY-U00006

Bioactivity: Duloxetine hydrochloride is a serotonin-norepinephrine Bioactivity: Duoperone is a neuroleptic agent and also a antiemetic agent reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for in animal models. treatment of major depressive disorder and generalized anxiety disorder (GAD).

Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

DWK-1339 Dyclonine hydrochloride (MDR-1339) Cat. No.: HY-14503 (Dyclocaine hydrochloride) Cat. No.: HY-B0364A

Bioactivity: DWK-1339 is an orally active and blood-brain-barrier-permeable Bioactivity: Dyclonine is an oral anaesthetic found in Sucrets, an over the Aβ-aggregation inhibitor, used in the research of Alzheimer's counter throat lozenge. disease.

Purity: 98.97% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 g, 10 g

Dynorphin A (1-10) TFA A 1-10 Cat. No.: HY-P1594A Cat. No.: HY-P1594

Bioactivity: (1-10) (TFA), an endogenous opioid neuropeptide, Bioactivity: Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to binds to extracellular loop 2 of the κ-opioid receptor. extracellular loop 2 of the κ-opioid receptor. Dynorphin A

Dynorphin A (1-10) (TFA) also blocks NMDA-activated current (1-10) also blocks NMDA-activated current with an IC50 of with an IC of 42.0 μM. 50 42.0 μM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

Dynorphin B 1-13 E 2012 Cat. No.: HY-P1337 Cat. No.: HY-10016

Bioactivity: (1-13) acts as an agonist on opioid κ-receptor. Bioactivity: E 2012 is a potent γ-secretase modulator. IC50 value: Target: γ-secretase In the present study, 9 dogs were treated with a single dose of the γ-secretase modulator E2012, the γ-secretase inhibitor LY450139, or vehicle with a dosing interval of 1 week. The isoform Aβ(1-37) was significantly… Purity: >98% Purity: 96.91% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 100 mg

www.MedChemExpress.com 49

E4CPG Echinacoside Cat. No.: HY-100372 Cat. No.: HY-N0020

Bioactivity: E4CPG is a novel group I/group II metabotropic glutamate Bioactivity: Echinacoside is a natural polyphenolic compound, has various receptor antagonist, more potent than (RS)-MCPG . kinds of pharmacological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative ones.

Purity: 98.0% Purity: 99.52% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Edaravone Edonerpic maleate (MCI-186) Cat. No.: HY-B0099 (T-817 maleate; T-817MA) Cat. No.: HY-17631A

Bioactivity: is a strong novel free radical scavenger, and Bioactivity: Edonerpic maleate is a novel neurotrophic agent which can inhibits MMP-9-related brain hemorrhage in rats treated inhibit amyloid-β ( Aβ). with tissue plasminogen activator.

Purity: 99.91% Purity: 99.40% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Edrophonium chloride EGTA-AM Cat. No.: HY-B0882 (EGTA Acetoxymethyl ester) Cat. No.: HY-D0973

Bioactivity: chloride is a readily reversible Bioactivity: EGTA-​AM is a membrane permeable form of EGTA, can be acetylcholinesterase inhibitor; prevents breakdown of the passively loaded into cells to generate intracellular EGTA; neurotransmitter acetylcholine and acts by competitively EGTA-​AM is also a Ca 2+ chelator with slow chelating inhibiting the enzyme acetylcholinesterase, mainly at the dynamics. neuromuscular junction. Purity: 98.0% Purity: 90.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg 100 mg, 500 mg

EHT 1864 EHT 5372 Cat. No.: HY-16659 Cat. No.: HY-111380

Bioactivity: EHT 1864 is a small molecule inhibitor of Rac1 signaling; Bioactivity: EHT 5372 is a strong inhibitor of DYRK’s family kinases, with modulate γ-Secretase-mediated APP processing. IC50s of 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively.

Purity: 99.60% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg

Eicosapentaenoic Acid Eicosapentaenoic acid ethyl ester (EPA; Timnodonic acid) Cat. No.: HY-B0660 (Ethyl eicosapentaenoate; EPA ethyl ester) Cat. No.: HY-B0747

Bioactivity: Eicosapentaenoic acid (EPA) is an omega-3 fatty acid. Bioactivity: Eicosapentaenoic acid ethyl ester is an omega-3 fatty acid agent.

Purity: 98.96% Purity: 98.0% Clinical Data: Launched Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg 50 mg, 100 mg, 500 mg

50 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Eledoisin Related Peptide hydrobromide (-Related Peptide; Eledoisin RP) Cat. No.: HY-P1186 (Eletriptan HBr) Cat. No.: HY-A0010

Bioactivity: Eledoisin Related Peptide is a Substance P analog that excites Bioactivity: Eletriptan HBr is a selective 5-HT1B and 5-HT1D receptor neurons and triggers behavioral responses. Eledoisin Related agonist with Ki of 0.92 nM and 3.14 nM, respectively. IC50 Peptide is also a ligand. value: 0.82 nM/3.14 nM (5-HT1B/5-HT1D, Ki) [1] Target: 5-HT1B/5-HT1D in vitro: [3H]Eletriptan has a total number of binding sites (Bmax) of 2478 fmol/mg and 1576 fmol/mg for… Purity: >98% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Eliprodil Ellagic acid (SL-820715) Cat. No.: HY-12881 Cat. No.: HY-B0183

Bioactivity: (SL-820715) is a non-competitive NR2B-NMDA receptor Bioactivity: Ellagic acid is a natural antioxidant, and acts as a potent

antagonist(IC50=1 uM), less potent for NR2A- and and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and NR2C-containing receptors(IC50> 100 uM). a Ki of 20 nM.

Purity: 99.67% Purity: 99.92% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 1 g, 5 g 10 mg, 50 mg

ELN484228 Cat. No.: HY-115038 (DU 28853) Cat. No.: HY-16687

Bioactivity: ELN484228 is a blocker of α-synuclein which is a key protein in Bioactivity: Eltoprazine(DU28853) is a serenic or antiaggressive agent Parkinson’s disease. which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.

Purity: 99.77% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 10 mg, 50 mg

Eltoprazine hydrochloride EMA401 (DU 28853 hydrochloride) Cat. No.: HY-16687A (Olodanrigan) Cat. No.: HY-13106

Bioactivity: Eltoprazine(DU28853) is a serenic or antiaggressive agent Bioactivity: EMA401, a highly selective AT2R antagonist, inhibition of which as an agonist at the 5-HT1A and 5-HT1B receptors and as augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, an antagonist at the 5-HT2C receptor. and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. target: AT2R In vivo: AngII induces p38, p42/p44 mitogen activated protein kinase (MAPK)… Purity: 99.35% Purity: 98.52% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Emapunil Emicerfont (AC-5216; XBD-173) Cat. No.: HY-15527 (GW876008) Cat. No.: HY-14367

Bioactivity: (AC-5216;XBD-173) is a [TSPO (18 Bioactivity: Emicerfont is a corticotropin-releasing factor type 1 (

kDa)] ligand. IC50 value: Target: TSPO ligand XBD173 enhanced CRF1) receptor antagonist with an IC50 of 66 nM. gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of and tolerance development. XBD173 also exerted… Purity: 99.83% Purity: >98% Clinical Data: Phase 1 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 51

EML 425 1 Cat. No.: HY-110263 Cat. No.: HY-P0185

Bioactivity: EML425 is a potent and selective CREB binding protein ( CBP)/ Bioactivity: Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively. kappa 3 binding sites, with Ki value between 20 and 30 nM. Sequence: Tyr-Pro-Trp-Phe-NH2.

Purity: >98% Purity: 98.15% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg

Endomorphin 2 -3, human, mouse, rabbit, rat Cat. No.: HY-P0186 ( (Rat,Human)) Cat. No.: HY-P0204

Bioactivity: Endomorphin 2, a high affinity, highly selective agonist of Bioactivity: Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid the μ-opioid receptor, displays reasonable affinities for vasoactive peptide that binds to G-protein-linked

kappa 3 binding sites, with Ki value between 20 and 30 nM. transmembrane receptors, ET-RA and ET-RB. Sequence: Tyr-Pro-Phe-Phe-NH2.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 500u g, 1 mg, 5 mg

Enecadin ENS-163 phosphate (ENS 213-163; Sandoz ENS 163 phosphate; Cat. No.: HY-100119 Thiopilocarpine phosphate) Cat. No.: HY-U00038

Bioactivity: Enecadin is a neuroprotective agent extracted from patent US Bioactivity: ENS-163 phosphate is a selective muscarinic M1 receptor 8623823 B2. agonist.

Purity: >98% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Entacapone sodium salt Cat. No.: HY-14280 Cat. No.: HY-14280A

Bioactivity: Entacapone is a specific, potent, peripherally acting Bioactivity: Entacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. nM for PD treatment.

Purity: 99.89% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

EP1-antanoist-1 Epiberberine chloride Cat. No.: HY-101695 Cat. No.: HY-N0226A

Bioactivity: EP1-antanoist-1 is a EP1 antagonist with a pKi of 7.54 and an Bioactivity: Epiberberine chloride, a natural alkaloid, is a BACE1 pIC of 8.5. inhibitor, which also exhibits inhibition activity on CYP2D6 50 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1. Purity: >98% Purity: 99.60% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

52 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Eplivanserin ERB-196 (SR-46349) Cat. No.: HY-10792 (WAY-202196) Cat. No.: HY-19468

Bioactivity: is a potent, selective and orally available Bioactivity: ERB-196 is a nonsteroidal selective estrogen receptor-β (

5-HT2 receptor antagonist, with an IC50 of 5.8 nM in rat ERβ) agonist.

cortical membrane, and a Kd of 1.14 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500 mg, 250 mg Size: 1 mg, 5 mg, 10 mg

Erianin Cat. No.: HY-N0517 ((S)-Citalopram; S-(+)-Citalopram) Cat. No.: HY-14258

Bioactivity: Erianin, often used as an antipyretic and analgesic agent, Bioactivity: Escitalopram is a selective serotonin reuptake inhibitor could inhibit IDO-induced tumor angiogenesis. (SSRI) with Ki of 0.89 nM. Target: SSRIs Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major… Purity: 99.52% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

Escitalopram oxalate Eslicarbazepine ((S)-(+)Citalopram oxalate) Cat. No.: HY-14258A (BIA 2-194; Stedesa) Cat. No.: HY-114703

Bioactivity: Escitalopram is a selective serotonin reuptake inhibitor Bioactivity: Eslicarbazepine is an oral anticonvulsant indicated for the (SSRI) with Ki of 0.89 nM. adjunctive treatment of partial seizures.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg

Eslicarbazepine acetate (BIA 2-093) Cat. No.: HY-B0703 (Ethamivan; N,N-Diethylvanillamide) Cat. No.: HY-B1096

Bioactivity: , an antiepileptic drug, is a dual a Bioactivity: Etamivan is a respiratory stimulant drug, mainly used in the dual Inhibitor of β-Secretase and voltage-gated sodium treatment of barbiturate overdose and chronic obstructive channel. pulmonary disease.

Purity: 99.48% Purity: 99.66% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 500 mg 100 mg

Ethosuximide Cat. No.: HY-B1378 Cat. No.: HY-101596

Bioactivity: , a widely prescribed anti-epileptic drug, Bioactivity: Ethyl dirazepate is a drug which is a benzodiazepine improves the phenotypes of multiple neurodegenerative disease derivative. It has anxiolytic and hypnotic and possibly other models and blocks the low voltage activated T-type calcium characteristic benzodiazepine properties. channel.

Purity: 99.54% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 500 mg

www.MedChemExpress.com 53

Ethylmalonic acid Cat. No.: HY-34740 (HOE 36-801) Cat. No.: HY-16579A

Bioactivity: Ethylmalonic acid is non-carcinogenic potentially toxic and Bioactivity: Etifoxine(HOE 36-801) is potentiator of GABAA receptor associated with and malonyl-CoA decarboxylase function in cultured neurons. Etifoxine preferentially acts on deficiency. β2 or β3 subunit-containing GABAA receptors.

Purity: >98% Purity: 99.94% Clinical Data: Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 5 mg, 10 mg, 50 mg, 100 mg

Etifoxine hydrochloride Etimizol (Antiffine; Ethimizole; Ethylnorantifein; (HOE 36-801) Cat. No.: HY-16579 Ethylnorantifeine; Ethylnorantiffeine; Ethymisol; …) Cat. No.: HY-13918

Bioactivity: Etifoxine Hcl(HOE 36-801) is potentiator of GABAA receptor Bioactivity: Etimizol(Ethymisole; Antiffine; Ethylnorantifein) was shown to function in cultured neurons. Etifoxine preferentially acts on relieve amnesia effectively in the origin of which there is β2 or β3 subunit-containing GABAA receptors. the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). IC50 Value: Target: Etimizol has a catalytic effect on the respiratory center and belongs… Purity: 99.96% Purity: 99.95% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Etomidate hydrochloride (R 16659) Cat. No.: HY-B0100 (R16659 hydrochloride) Cat. No.: HY-B0100A

Bioactivity: Etomidate(R-16659) is a GABAA receptors agonist, which is a Bioactivity: Etomidate Hcl(R16659 Hcl) is a GABAA receptors agonist, which short acting intravenous anaesthetic agent used for the is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia. induction of general anaesthesia.

Purity: 99.33% Purity: 99.09% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Eucalyptol Eupatilin (1,8-Cineole) Cat. No.: HY-N0066 Cat. No.: HY-N0783

Bioactivity: Eucalyptol is an inhibitor of 5-HT3 receptor , potassium Bioactivity: Eupatilin, a lipophilic isolated from Artemisia channel, TNF-α and IL-1β. species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.

Purity: 98.0% Purity: 99.01% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 5 mg, 10 mg, 25 mg, 50 mg

EVP-6124 EVP-6124 hydrochloride () Cat. No.: HY-15430 (Encenicline hydrochloride) Cat. No.: HY-15430A

Bioactivity: EVP-6124 is a novel partial agonist of α7 neuronal nicotinic Bioactivity: EVP-6124 hydrochloride is a novel partial agonist of α7 acetylcholine receptors ( nAChRs). neuronal nicotinic acetylcholine receptors ( nAChRs).

Purity: >98% Purity: 98.20% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

54 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Exendin-3 F 11440 Cat. No.: HY-P1543 ( free base) Cat. No.: HY-19946

Bioactivity: Exendin-3 is a biologically active peptides isolated from Bioactivity: F 11440 is a potent, selective, high efficacy 5-HT1A receptor venoms of the Gila monster lizards, Heloderma horridurn . agonist with marked anxiolytic and antidepressant potential.

Purity: >98% Purity: 99.80% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

F-15599 Cat. No.: HY-19863 (CM346) Cat. No.: HY-14895

Bioactivity: F-15599 is a highly selective G-protein biased 5-HT1A Bioactivity: Fabomotizole is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle receptor agonist, with Ki of 3.4 nM. relaxant actions.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

Fabomotizole hydrochloride (CM346 hydrochloride) Cat. No.: HY-14895A (CX-691; Org24448) Cat. No.: HY-10937

Bioactivity: Fabomotizole hydrochloride is an anxiolytic drug; produces Bioactivity: Farampator (CX-691;Org24448) is an AMPA receptor positive anxiolytic and neuroprotective effects without any sedative or modulator. muscle relaxant actions.

Purity: 99.21% Purity: 98.90% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Felbamate hydrate Cat. No.: HY-B0184 Cat. No.: HY-B0184A

Bioactivity: Felbamate (FBM) is a potent nonsedative anticonvulsant whose Bioactivity: Felbamate hydrate (FBM) is a potent nonsedative anticonvulsant clinical effect may be related to the inhibition of whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) . N-methyl-D-aspartate (NMDA) .

Purity: 98.30% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg, 50 mg, 100 mg, 200 mg

Fenmetozole Tosylate fumarate Cat. No.: HY-U00402 (Toviaz) Cat. No.: HY-A0030

Bioactivity: Tosylate is an antagonist of the actions of Bioactivity: Fesoterodine Fumarate is an antimuscarinic agent and is , also antagonizes α2-adrenergic receptor, and acts as rapidly de-esterified to its 5-hydroxymethyl an antidepressant drug. tolterodine that is a muscarinic receptor antagonist. IC50 value: Target: mAChR Fesoterodine has the advantage of allowing more flexible dosage than other muscarinic… Purity: >98% Purity: 99.52% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg

www.MedChemExpress.com 55

Fexofenadine hydrochloride (MDL-16455 hydrochloride; FG8119 Terfenidine carboxylate hydrochloride) Cat. No.: HY-B0801A (NNC13-8119) Cat. No.: HY-U00233

Bioactivity: is a third-generation antihistamine Bioactivity: FG8119 is a novel benzodiazepine agonist extracted from patent pharmaceutical drug used in the treatment of allergy symptoms, US 4745112 A. such as hay fever, nasal congestion, and urticaria.

Purity: 99.61% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg

FGFR4-IN-1 Cat. No.: HY-100631 Cat. No.: HY-B1124

Bioactivity: FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 Bioactivity: Fipexide is a psychoactive drug of the chemical nM. class, used as a nootropic drug, mainly for the treatment of senile dementia.

Purity: 99.93% Purity: 99.87% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg

Firategrast Fisetin (SB 683699) Cat. No.: HY-14951 Cat. No.: HY-N0182

Bioactivity: Firategrast is an orally bioavailable α4β1/ α4β7 Bioactivity: Fisetin is a natural flavonol found in many fruits and antagonist. vegetables with various benefits, such as antioxidant, anticancer, effects.

Purity: 99.66% Purity: 98.0% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg, 1 g

FK1052 hydrochloride Flaconitine Cat. No.: HY-101638 (Acetylaconitine; 3-Acetylaconitine) Cat. No.: HY-N0276

Bioactivity: FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor Bioactivity: Flaconitine is isolated from the ammonium hydroxide wetted dual antagonist. root of A.szechenyianum Gay. Flaconitine is considered to be a NF-κB inhibitor.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg

Flavoxate hydrochloride (Rec-7-0040; DW61) Cat. No.: HY-B0549A (BIMT-17; BIMT-17BS) Cat. No.: HY-A0095

Bioactivity: Hydrochloride(DW-61 Hydrochloride) is a muscarinic Bioactivity: Flibanserin is a novel multifunctional serotonin agonist and AChR antagonist used in various urinary syndromes and as an antagonist (MSAA) that improves sexual functioning in antispasmodic. premenopausal women who suffer from reduced sexual interest and desire.

Purity: 99.0% Purity: 99.31% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 1 g 5 mg, 10 mg, 50 mg, 100 mg

56 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Flopropione Cat. No.: HY-100562 (Ro 15-1788) Cat. No.: HY-B0009

Bioactivity: is a 5-HT1A receptor antagonist and also a Bioactivity: Flumazenil is a competitive GABAA receptor antagonist, used catechol-o-methyltransferase ( COMT) inhibitor. in the treatment of benzodiazepine overdoses.

Purity: 98.37% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg, 100 mg

Flunarizine dihydrochloride Cat. No.: HY-B0358A (LY-110140) Cat. No.: HY-B0102

Bioactivity: is a selective calcium entry blocker. Bioactivity: Fluoxetine is a selective serotonin reuptake inhibitor ( SSRI) class used for antidepressant research.

Purity: 99.76% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 50 mg, 100 mg, 500 mg 500 mg

Fluoxetine hydrochloride dihydrochloride (LY-110140) Cat. No.: HY-B0102A (Flupenthixol dihydrochloride) Cat. No.: HY-15856B

Bioactivity: Fluoxetine (hydrochloride) is a selective serotonin reuptake Bioactivity: Flupentixol dihydrochloride, a drug, is used in inhibitor (SSRI) class used for antidepressant research. therapy of schizophrenia as well as in anxiolytic and depressive disorders.

Purity: 99.86% Purity: 99.73% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg 5 mg, 10 mg

Fluphenazine dihydrochloride Cat. No.: HY-A0081 (D 9998) Cat. No.: HY-17001A

Bioactivity: dihydrochloride is a phenothiazine-class D1DR and Bioactivity: Flupirtine(D 9998) is a selective neuronal potassium channel D2DR inhibitor; used to deliver Fluphenazine to biological opener that also has NMDA receptor antagonist properties. systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist.

Purity: 99.96% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg, 500 mg 100 mg

Flupirtine Maleate Cat. No.: HY-17001 (2,2,2-Trifluoroethyl vinyl ether) Cat. No.: HY-B1163

Bioactivity: Flupirtine Maleate(D 9998) is a selective neuronal potassium Bioactivity: Fluroxene is a volatile, , and was the that also has NMDA receptor antagonist first halogenated hydrocarbon anesthetic to be introduced. properties. IC50 Value: Target: Potassium channel; NMDA receptor in vitro: High concentrations of flupirtine antagonized inward currents to NMDA(200 microM) at -70 mV with… Purity: 99.97% Purity: 99.70% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 500 mg 100 mg

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Flutazolam (MS 4101; Ro 7-6102) Cat. No.: HY-111481 Cat. No.: HY-B0103

Bioactivity: (MS 4101; Ro 7-6102) is a medicine acts on Bioactivity: Fluvoxamine is an antidepressant which functions benzodiazepine receptors of the brain and relieves anxiety or pharmacologically as a selective serotonin reuptake inhibitor. tension.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10 mg, 50 mg, 100 mg

Fluvoxamine maleate Fluzinamide Cat. No.: HY-B0103A (AHR-8559) Cat. No.: HY-101802

Bioactivity: Fluvoxamine maleate is an antidepressant which functions Bioactivity: Fluzinamide is an effective antiepileptic. pharmacologically as a selective serotonin reuptake inhibitor.

Purity: 99.85% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

Fmoc-1,6-diaminohexane Fonadelpar Cat. No.: HY-103664 (NPS-005; SJP-0035) Cat. No.: HY-17633

Bioactivity: Fmoc-1,6-diaminohexane is an analog of Osw-1 which can be used Bioactivity: Fonadelpar is a PPARδ agonist, used in the research of to treat Alzheimer's disease and cancer, extracted from patent neuroparalytic keratopathy. US 20140135279 A1.

Purity: 99.27% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 200 mg

Fosaprepitant dimeglumine (L-758298) Cat. No.: HY-14407 (MK-0517) Cat. No.: HY-14407A

Bioactivity: Fosaprepitant (L-758298) is a neurokinin-1 receptor antagonist Bioactivity: Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor for the prevention of chemotherapy-induced nausea and antagonist for the prevention of chemotherapy-induced nausea vomiting. and vomiting.

Purity: >98% Purity: 99.0% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg Size: 5 mg, 10 mg, 50 mg

Fosphenytoin disodium FPS-ZM1 Cat. No.: HY-B1657A Cat. No.: HY-19370

Bioactivity: sodium is a prodrug with similar Bioactivity: FPS-ZM1 is a high-affinity inhibitor with a Ki of 25 nM. anticonvulsant properties.

Purity: 98.0% Purity: 99.70% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

58 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Fursultiamine Cat. No.: HY-B2082 Cat. No.: HY-A0057

Bioactivity: Fursultiamine is a vitamin B1 derivative. Bioactivity: Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve . IC50 Value: 140 nM (α2δ subunit of calcium channel) [1] Target: Calcium Channel in vitro: Gabapentin, baclofen and CGP 44532… Purity: 99.72% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

Gabapentin enacarbil Gabapentin hydrochloride (XP-13512) Cat. No.: HY-16216 Cat. No.: HY-A0057A

Bioactivity: (XP-13512) is a prodrug for the Bioactivity: Gabapentin (Neurontin) is a pharmaceutical drug, specifically anticonvulsant and analgesic drug gabapentin. a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.

Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 10 mg, 50 mg, 100 mg

Gabazine (1-16), mouse, porcine, rat (SR95531) Cat. No.: HY-103533 Cat. No.: HY-P1578

Bioactivity: is a selective and competitive antagonist of GABAA Bioactivity: Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal , with a Kd of 3 nM. receptor, with an IC50 of ~0.2 μM for GABA receptor.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg, 50 mg, 100 mg

Galanin (1-16), mouse, porcine, rat TFA Galanin (1-30), human Cat. No.: HY-P1578A Cat. No.: HY-P1127

Bioactivity: Galanin (1-16), mouse, porcine, rat (TFA) is an agonist of the Bioactivity: Galanin (1-30), human is a 30-amino acid neuropeptide, and

hippocampal galanin receptor, with a Kd of 3 nM. acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 500u g, 1 mg, 5 mg

Galanthamine Galanthamine hydrobromide () Cat. No.: HY-76299 (Galantamine hydrobromide) Cat. No.: HY-A0009

Bioactivity: Galanthamine is a potent acetylcholinesterase ( AChE) Bioactivity: Galanthamine hydrobromide is a long-acting, centrally active

inhibitor with an IC50 of 500 nM. acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChE Galanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine… Purity: 99.78% Purity: 99.53% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 100 mg, 500 mg

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Galanthaminone Galantide ((-)-Narwedine; Narwedin) Cat. No.: HY-I0020 Cat. No.: HY-P0262

Bioactivity: Galanthaminone (Narwedin) is a competitive and reversible Bioactivity: Galantide is a reversible and non-specific galanin receptor cholinesterase (AChE) inhibitor; is used for the treatment of antagonist. Sequence: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu- mild to moderate Alzheimer's disease and various other memory Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. impairments.

Purity: 99.53% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg, 25 mg

gamma-DGG gamma-secretase modulator 1 (γDGG; γ-D-Glutamylglycine) Cat. No.: HY-100785 Cat. No.: HY-10043

Bioactivity: gamma-DGG is a competitive AMPA receptor blocker. Bioactivity: γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

Purity: 98.08% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 100 mg

gamma-secretase modulator 2 gamma-secretase modulator 3 Cat. No.: HY-50754 Cat. No.: HY-50889

Bioactivity: gamma-secretase modulator 2 is a potent and selective Bioactivity: gamma-secretase modulator 3 is a gamma-secretase modulator. γ-secretase modulator for treatment of Alzheimer's disease.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 100 mg

gamma-Secretase Modulators Gastrodin (Amyloid-β production inhibitor; γ-Secretase Modulators) Cat. No.: HY-50900 (Gastrodine) Cat. No.: HY-N0115

Bioactivity: gamma-Secretase Modulators (Amyloid-β production inhibitor) is Bioactivity: Gastrodin, a main constituent of a Chinese herbal medicine a Amyloid-β production inhibitor. gamma-Secretase Modulators Tianma, has been known to display anti-inflammatory effects. is useful for Alzheimer's disease. Gastrodin, has long been used for treating , epilepsy, stroke and dementia.

Purity: >98% Purity: 99.40% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 25 mg, 50 mg, 100 mg

GBR 12935 GBR 12935 dihydrochloride Cat. No.: HY-12242A Cat. No.: HY-12242

Bioactivity: GBR 12935 is a potent, and selective dopamine reuptake Bioactivity: GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor. IC50 value: Target: dopamine reuptake inhibitor in inhibitor. vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6. The binding of [3H]GBR-12935 to CYP2D6 was decreased… Purity: >98% Purity: 98.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

60 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Geniposide GIBH-130 Cat. No.: HY-N0009 Cat. No.: HY-101860

Bioactivity: Geniposide is an iridoid glucoside extracted from Gardenia Bioactivity: GIBH-130 is an effective inhibitor of neuroinflammation. jasminoides Ellis fruits; exhibits a varity of biological GIBH-130 significantly suppresses the IL-1β secretion by

activities such as anti-diabetic, antioxidative, activated microglia ( IC50=3.4 nM). antiproliferative and neuroprotective activities.

Purity: 99.52% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Gidazepam C (Gidasepam; Hidazepam; Hydazepam) Cat. No.: HY-U00315 (BN-52022; Ginkgolide-C) Cat. No.: HY-N0785

Bioactivity: is an agonist of GABA receptor channels ( GABA Bioactivity: Ginkgolide C is a flavone isolated from Ginkgo biloba leaves, RCs). possessing multiple biological functions, such as decreasing aggregation and ameliorating Alzheimer disease.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Ginsenoside Rc Ginsenoside Re (Ginsenoside B2; Panaxoside Re; (Panaxoside Rc) Cat. No.: HY-N0042 Chikusetsusaponin IVc; Sanchinoside Re) Cat. No.: HY-N0044

Bioactivity: Ginsenoside Rc, one of major Ginsenosides from Panax , Bioactivity: Ginsenoside Re is an extract from Panax notoginseng. Ginsenoside

enhances GABA receptor A ( GABAA)-mediated Re decreases the β-amyloid protein ( Aβ). Ginsenoside Re currents (I ). Ginsenoside Rc inhibits the expression of plays a role in antiinflammation through inhibition of JNK GABA and NF-κB. TNF-α and IL-1β. Purity: 98.0% Purity: 98.09% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg

Ginsenoside Rf Ginsenoside Rg1 (Panaxoside Rf) Cat. No.: HY-N0601 (Panaxoside A; Panaxoside Rg1) Cat. No.: HY-N0045

Bioactivity: Ginsenoside Rf is a trace component of ginseng root. Bioactivity: Ginsenoside Rg1 is one of the major active components of Ginsenoside Rf inhibits N-type Ca2+ channel. ginseng. Ginsenoside Rg1 displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.

Purity: 94.90% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg

Ginsenoside Rg2 Ginsenoside Rg3 (Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2) Cat. No.: HY-N0602 (20(S)-Ginsenoside-Rg3; Rg3; S-Ginsenoside Rg3) Cat. No.: HY-N0603

Bioactivity: Ginsenoside Rg2 is one of the major active components of Bioactivity: Ginsenoside Rg3 is the main component of Red ginseng. ginseng. Ginsenoside Rg2 acts as a NF-κB inhibitor. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC Ginsenoside Rg2 also reduces Aβ accumulation. 1-42 50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2<… Purity: 99.24% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 10 mg, 50 mg, 100 mg

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GLN-1062 (19-29), human Cat. No.: HY-101710 Cat. No.: HY-P0150

Bioactivity: Memogain is a pro-drug of galantamine, used for the treatment Bioactivity: Glucagon (19-29), human is a potent and efficient inhibitor of for Alzheimer’s disease. insulin secretion.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 25 mg

Glutaminyl Cyclase Inhibitor 1 Glutaminyl Cyclase Inhibitor 2 Cat. No.: HY-112269 Cat. No.: HY-112270

Bioactivity: Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase Bioactivity: Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase

inhibitor with an IC50 of 0.5 μM. inhibitor with an IC50 of 1.23 μM.

Purity: 98.34% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 250 mg, 500 mg

Gluten C Glycine Cat. No.: HY-P1596 Cat. No.: HY-Y0966

Bioactivity: Gluten exorphin C is an opioid peptide derived from wheat Bioactivity: Glycine is an inhibitory neurotransmitter in the CNS and also

gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and acts as a co-agonist along with glutamate, facilitating an δ opioid activities in the GPI and MVD assays, respectively. excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 1 g

Glycopyrrolate Glycoursodeoxycholic acid (Glycopyrrolate bromide; ) Cat. No.: HY-17465 (Ursodeoxycholylglycine) Cat. No.: HY-N1424

Bioactivity: Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive Bioactivity: Glycoursodeoxycholic acid, a acyl glycine and a bile antagonist used as an antispasmodic. acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg

GNE 0723 GNE 5729 Cat. No.: HY-108337 Cat. No.: HY-107409

Bioactivity: GNE 0723 is a brain permeable positive allosteric modulator of Bioactivity: GNE 5729 is a brain permeable positive allosteric modulator of

NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. for GluN2C and GluN2D, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 250 mg, 500 mg

62 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

GNE-7915 GNE-7915 tosylate Cat. No.: HY-18163 Cat. No.: HY-18163A

Bioactivity: GNE-7915 is a potent, selective and brain-penetrant inhibitor Bioactivity: GNE-7915 tosylate is a potent, selective and brain-penetrant

of LRRK2 with an IC50 of 9 nM. inhibitor of LRRK2 with an IC50 of 9 nM.

Purity: 98.77% Purity: 98.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg 10 mg, 50 mg, 100 mg

GNE-9605 GNE0877 Cat. No.: HY-12282 Cat. No.: HY-15796

Bioactivity: GNE-9605 is a highly potent, selective, and brain-penetrant Bioactivity: GNE0877 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM. IC50 value: Target: LRRK2 aminopyrazole -rich repeat kinase 2 (LRRK2) small GNE-9605 retained excellent predicted human metabolic molecule inhibitor with an IC50 of 3 nM. IC50 value: 3 nM [1] stability when assayed in human liver microsomes and Target: LRRK2 Invitrogen kinase-selectivity profiling(188 hepatocytes. In addition, no reversible or time-dependent… kinases) of aminopyrazole GNE0877 at 0.1 μM (145-fold… Purity: 99.26% Purity: 98.64% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg

GNF-PF-3777 (8-Nitrotryptanthrin) Cat. No.: HY-100687 Cat. No.: HY-B0071

Bioactivity: 8-Nitrotryptanthrin is a potent human indoleamine Bioactivity: Granisetron is a serotonin 5-HT3 receptor antagonist used as 2,3-dioxygenase 2 (h IDO2) inhibitor which significantly reduces an antiemetic to treat nausea and vomiting following chemotherapy. IDO2 activity with Ki of 0.97 μM.

Purity: 99.21% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Granisetron Hydrochloride GSK-269984A (BRL 43694A) Cat. No.: HY-B0071A Cat. No.: HY-14467

Bioactivity: Granisetron Hcl(BRL 43694A) is a serotonin 5-HT3 receptor Bioactivity: GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist antagonist used as an antiemetic to treat nausea and vomiting with a pIC50 of 7.9. following chemotherapy.

Purity: 99.69% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 50 mg, 100 mg

GSK-2881078 GSK1059865 Cat. No.: HY-100186 Cat. No.: HY-101534

Bioactivity: GSK 2881078 is a selective androgen receptor modulator Bioactivity: GSK1059865 is a potent orexin 1 receptor antagonist. potentially for the treatment of cachexia.

Purity: 99.37% Purity: 99.91% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 63

GSK163090 GSK189254A Cat. No.: HY-14348 Cat. No.: HY-14111

Bioactivity: GSK163090 is a potent, selective, and orally active 5-HT1A/B/D Bioactivity: GSK189254A (GSK189254) is a novel, potent and selective

receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for histamine H3 receptor antagonist with pKi values of 9.59-9.90 5-HT1A/B/D, and dopamine D2/D3, respectively. and 8.51-9.17 for human and rat H3, respectively.

Purity: 99.62% Purity: 98.58% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

GSK2578215A GSK598809 Cat. No.: HY-13237 Cat. No.: HY-19654

Bioactivity: GSK2578215A is a potent and highly selective LRRK2 inhibitor; Bioactivity: GSK598809 is a potent and selective dopamine D3 Receptor

exhibits IC50s of around 10 nM against both wild-type LRRK2 (DRD3) antagonist, with a pKi of 8.9. and the G2019S mutant. IC50 value: ~10 nM(wt-LRRK2; LRRK2 G2019S) [1] Target: LRRK2 inhibitor GSK2578215A exhibits exceptionally high selectivity for LRRK2 across the kinome,… Purity: 99.86% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500 mg, 250 mg 5 mg, 10 mg, 50 mg, 100 mg

Guanethidine sulfate ( monosulfate) Cat. No.: HY-B0800 Cat. No.: HY-17416A

Bioactivity: Guanethidine is an that reduces the Bioactivity: Guanfacine is a selective α2A receptor agonist. Target: α2A release of , such as norepinephrine. Receptor Guanfacine is a . It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with… Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10 mg, 50 mg 100 mg, 500 mg

Guvacine hydrochloride GV-196771A Cat. No.: HY-100809 Cat. No.: HY-19243

Bioactivity: hydrochloride is an alkaloid from the nut of Areca Bioactivity: GV-196771A is the sodium salt form of GV196771, is an NMDA catechu, acts as an inhibitor of GABA transporter, and receptor antagonist. dispalys modest selectivity for cloned GABA transporters with

IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM… Purity: 99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg

GV-58 GW1929 Cat. No.: HY-12498 Cat. No.: HY-15655

Bioactivity: GV-58 is a potent, selective N- and P/Q-type Ca2+ channels Bioactivity: GW1929 is a potent PPAR-γ activator, with pK is of 8.84, < agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ 5.5, and < 6.5 for human PPAR-γ, PPAR-α, and PPAR-δ, and channel; 20-fold less potent CDK inhibitor activity. pEC 50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. Purity: 98.68% Purity: 99.68% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 5 mg, 10 mg, 25 mg, 50 mg

64 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

GW791343 dihydrochloride GW791343 trihydrochloride Cat. No.: HY-15469 Cat. No.: HY-15470

Bioactivity: GW791343 2Hcl is a P2X7 allosteric modulator; exhibits Bioactivity: GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). modulator of human P2X7 (pIC50 = 6.9 - 7.2).

Purity: 94.07% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

GW842166X GYKI53655 hydrochloride Cat. No.: HY-14167 Cat. No.: HY-103228

Bioactivity: GW842166X is a potent and selective 2 Bioactivity: GYKI53655 hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ( (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively. AMPA) antagonist.

Purity: 99.97% Purity: 99.01% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg, 100 mg

H-1152 H-1152 dihydrochloride Cat. No.: HY-15720 Cat. No.: HY-15720A

Bioactivity: H-1152 is a membrane-permeable and selective ROCK inhibitor, Bioactivity: H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a K value of 1.6 nM, and an IC value with a Ki value of 1.6 nM, and an IC50 value of 12 nM for i 50 ROCK2. of 12 nM for ROCK2.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

H-Phe-Phe-OH H3 receptor antagonist 1 Cat. No.: HY-W007970 Cat. No.: HY-U00269

Bioactivity: H-Phe-Phe-OH is a peptide made of two molecules; Bioactivity: H3 receptor antagonist 1 is an antagonist of histamine H3 Phenylalanine is an essential amino acid and the precursor for receptor, used in the research of neurological disease. the amino acid .

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

Haloperidol D4' Cat. No.: HY-14538 Cat. No.: HY-14538S1

Bioactivity: Haloperidol is a potent dopamine D2 receptor antagonist, Bioactivity: Haloperidol D4' is deuterium labeled haloperidol, and the widely used as an antipsychotic. latter is a potent dopamine D2 receptor antagonist.

Purity: 99.72% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 100 mg, 500 mg

www.MedChemExpress.com 65

Haloperidol hydrochloride Cat. No.: HY-14538A Cat. No.: HY-B1010

Bioactivity: Haloperidol hydrochloride is a potent dopamine D2 receptor Bioactivity: Halothane is an inhalational general anesthetic. It is the antagonist, widely used as an antipsychotic. only inhalational anesthetic containing bromine.

Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg

Harmaline (Harmidine) Cat. No.: HY-107828 (Telepathine) Cat. No.: HY-N0737A

Bioactivity: is a potent and reversible monoamine oxidase Bioactivity: Harmine is a natural dual-specificity tyrosine inhibitor in vivo. Harmaline is a central nervous system phosphorylation-regulated kinase ( (DYRK)) inhibitor with stimulant and can be used to induce tremor in rodents. anticancer and anti-inflammatory activities.

Purity: 99.30% Purity: 99.58% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 500 mg

HC-030031 HC-070 Cat. No.: HY-15064 Cat. No.: HY-112302

Bioactivity: HC-030031 is a potent and selective of TRPA1 inhibitor, which Bioactivity: HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM antagonizes AITC- and formalin-evoked calcium influx with and 46 nM for hTRPC5 and hTRPC4 in cells, respectively. IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.

Purity: 98.01% Purity: 98.23% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Heparan Sulfate Hesperetin Cat. No.: HY-101916 Cat. No.: HY-N0168

Bioactivity: Heparan sulfate, a complex and linear polysaccharide, exists Bioactivity: Hesperetin is a natural flavanone, and acts as a potent and as part of glycoproteins named heparan sulfate proteoglycans, broad-spectrum inhibitor against human UGT activity. which are expressed abundantly on the cell surface and in the extracellular matrix.

Purity: Purity: 98.04% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 50 mg

Heterocyclyl carbamate derivative 1 Bromide Cat. No.: HY-101831 Cat. No.: HY-B0569

Bioactivity: Heterocyclyl carbamate derivative 1 is a heterocyclyl Bioactivity: Hexamethonium is a non-depolarising , a carbamate derivative that may be used for the research of nicotinic nACh (NN) receptor antagonist. inflammatory and neurological diseases.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

66 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

HG-10-102-01 Histamine (LRRK2 inhibitor 1) Cat. No.: HY-13488 (Ergamine) Cat. No.: HY-B1204

Bioactivity: HG-10-102-01 is a potent and selective inhibitor of wild-type Bioactivity: Histamine is an organic nitrogenous compound involved in local LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM) IC50 immune responses as well as regulating physiological function Value: 23.3 nM (WT LRRK2); 3.2 nM (LRRK2 G2019S) [1] Target: in the gut and acting as a neurotransmitter. LRRK2 HG-10-102-01 maintains the ability to potently inhibit the biochemical activity of wild-type and G2019S mutant LRRK2.… Purity: 99.54% Purity: 99.25% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg 100 mg

Histamine phosphate Hoechst 34580 (Histamine diphosphate) Cat. No.: HY-A0129 (HOE 34580) Cat. No.: HY-15560

Bioactivity: Histamine diphosphate is a potent agonist of histamine Bioactivity: Hoechst 34580 is a cell-permeable fluorescent dye for staining receptors and vasodilator. It can activate nitric oxide DNA and nuclei. synthetase.

Purity: 99.40% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 5 mg, 10 mg, 50 mg, 100 mg 1 g

Hoechst 34580 tetrahydrochloride Bromide (HOE 34580 tetrahydrochloride) Cat. No.: HY-15560B (Homatropine hydrobromide) Cat. No.: HY-B0547A

Bioactivity: Hoechst 34580 tetrahydrochloride is a cell-permeable Bioactivity: Homatropine Bromide is muscarinic AChR antagonist that is an fluorescent dye for staining DNA and nuclei. anticholinergic medication.

Purity: 99.65% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 g, 5 g

Homatropine methylbromide HQ-415 (Homatropine methobromide) Cat. No.: HY-B1388 Cat. No.: HY-18670

Bioactivity: Homatropine Methylbromide is muscarinic AChR antagonist, Bioactivity: HQ-415 is a class of clinically relevant bioactive metal inhibits endothelial and smooth muscle muscarinic receptors of chelators related to clioquinol. The effective concentration WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, eliciting a EC50 for HQ-415 is 15 μM. respectively.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

HT-2157 Hydroquinidine (SNAP 37889) Cat. No.: HY-100717 (Dihydroquinidine; (+)-Hydroquinidine; Hydroconquinine) Cat. No.: HY-B0997

Bioactivity: HT-2157 (SNAP 37889) is a selective, high-affinity, Bioactivity: Hydroquinidine is an .

competitive antagonists of galanin-3 receptor ( Gal3).

Purity: 98.0% Purity: 99.92% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg

www.MedChemExpress.com 67

Hypotaurine (2-Aminoethanesulfinic acid) Cat. No.: HY-100803 ((RS)-Ibotenic acid; DL-Ibotenic acid) Cat. No.: HY-N2311

Bioactivity: (2-aminoethanesulfinic acid), an intermediate in Bioactivity: Ibotenic acid has agonist activity at both the biosynthesis from cysteine in astrocytes, is an N-methyl-D-aspartate ( NMDA) and trans-ACPD or

endogenous inhibitory amino acid of the . metabolotropic quisqualate (Q m) receptor sites.

Purity: 98.36% Purity: 98.27% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in Water, 50 mg 5 mg, 10 mg, 25 mg, 50 mg

IC87201 ICA-069673 Cat. No.: HY-100457 Cat. No.: HY-101396

Bioactivity: IC87201, an inhibitor of PSD95-nNOS protein-protein Bioactivity: ICA-069673 is a KCNQ2/Q3 potassium channel activator with an interactions, suppresses NMDAR-dependent NO and cGMP IC50 of 0.69 μM. formation.

Purity: 95.53% Purity: 98.12% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ICI 118,551 hydrochloride Idebenone (ICI 118551 hydrochloride) Cat. No.: HY-13951 Cat. No.: HY-N0303

Bioactivity: ICI 118,551 (hydrochloride) is a highly selective β2 Bioactivity: Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which initially developed for the treatment of Alzheimer's adrenergic receptor antagonist, with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. disease and other cognitive defects. Target: Others Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which initially developed for the treatment of Alzheimer's disease… Purity: 98.50% Purity: 99.73% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

Idramantone tartrate (Kemantane; 5-Hydroxy-2-adamantanone) Cat. No.: HY-B1044 Cat. No.: HY-12882A

Bioactivity: Idramantone is an immune agonist. Bioactivity: Ifenprodil tartrate is a novel N-methyl-D-aspartate (NMDA) receptor antagonist that selectively inhibits receptors containing the NR2B subunit.

Purity: 98.0% Purity: 97.61% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg, 100 mg

Iloperidone hydrochloride (HP 873) Cat. No.: HY-17410 (HP 873 hydrochloride) Cat. No.: HY-17410A

Bioactivity: Iloperidone(HP 873) is a D2/5-HT2 receptor antagonist, which Bioactivity: Iloperidone (hydrochloride) is a D(2)/5-HT(2) receptor is an atypical antipsychotic for the treatment of antagonistis, which is an atypical antipsychotic for the schizophrenia symptoms. treatment of schizophrenia symptoms.

Purity: 99.93% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

68 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Imidacloprid Cat. No.: HY-B0838 (KRP-197; ONO-8025) Cat. No.: HY-B0662

Bioactivity: Imidacloprid is an effective and widely used neonicotinoid Bioactivity: Imidafenacin(KRP-197; ONO-8025) is a potent and selective pesticide to control pests of cereals, vegetables, tea and inhibitor of M3 receptors with Kb of 0.317 nM; less potent for cotton. M2 receptors(IC50=4.13 nM).

Purity: 98.27% Purity: 98.38% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg 200 mg, 500 mg

Imipramine hydrochloride Imoxiterol Cat. No.: HY-B1490 (RP 58802B) Cat. No.: HY-101585

Bioactivity: hydrochloride inhibits serotonin transporter with an Bioactivity: Imoxiterol is a β-adrenergic agonist.

IC50 value of 32 nM in vitro.

Purity: 99.89% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

Imperatorin (Ammidin) Cat. No.: HY-N0285 Cat. No.: HY-14299

Bioactivity: Imperatorin is an effective of NO synthesis inhibitor ( Bioactivity: Indacaterol(Onbrez; Arcapta) is an ultra-long-acting β-adrenoceptor agonist. IC50=9.2 μmol), which also is a BChE inhibitor ( IC50=31.4

μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM. Purity: 98.11% Purity: 96.17% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg

Ipenoxazone (MLV-6976; NC-1200) Cat. No.: HY-100159 (Sch 1000) Cat. No.: HY-B0241

Bioactivity: Ipenoxazone is a potent and centrally acting muscle relaxant. Bioactivity: Ipratropium Bromide is a muscarinic antagonist, , N-Isopropyl salt of atropine.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg

Iproniazid phosphate IPSU Cat. No.: HY-B0886 Cat. No.: HY-13796

Bioactivity: is a non-selective, irreversible monoamine oxidase Bioactivity: IPSU is a selective, orally available and brain penetrant

inhibitor (MAOI) of the hydrazine class. OX2R antagonist with a pKi of 7.85.

Purity: 99.92% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 25 mg, 50 mg

www.MedChemExpress.com 69

Irindalone IRL-1620 (Lu 21-​098) Cat. No.: HY-101632 Cat. No.: HY-16465

Bioactivity: Irindalone is a novel serotonin 5-HT2 antagonist. Bioactivity: IRL-1620 is a potent and selective type B (ETB) agonist with a Ki of 16 pM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 500u g, 1 mg, 5 mg

Isocorynoxeine hydrochloride (7-Isocorynoxeine) Cat. No.: HY-N0775 Cat. No.: HY-100810

Bioactivity: Isocorynoxeine, an isorhynchophylline-related alkaloid, Bioactivity: Isoguvacine hydrochloride is a GABA receptor agonist.

exhibits a dose-dependent inhibition of 5-HT2A

receptor-mediated current response with an IC50 of 72.4 μM.

Purity: 99.52% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 25 mg, 50 mg, 100 mg

Isoimperatorin Isospaglumic acid Cat. No.: HY-N0286 (N-Acetylaspartylglutamic acid; NAAG; α-Spaglumic acid) Cat. No.: HY-100921

Bioactivity: Isoimperatorin is a methanolic extract of the roots of Angelica Bioactivity: Isospaglumic acid is a neuropeptide found in millimolar dahurica shows significant inhibitory effects on concentrations in brain.

acetylcholinesterase ( AChE) with the IC50 of 74.6 μM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 10 mg, 50 mg

Isovaleramide ISRIB trans-isomer (3-Methylbutanamide) Cat. No.: HY-B1229 Cat. No.: HY-12495

Bioactivity: is an active principle on central nervous system Bioactivity: ISRIB (trans-isomer) is a potent inhibitor of PERK with an from Valeriana pavonii, as an anticonvulsant. IC50 of 5 nM.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Istradefylline ISX-9 (KW-6002) Cat. No.: HY-10888 (Isoxazole 9) Cat. No.: HY-12323

Bioactivity: is a very potent, selective and orally active Bioactivity: ISX-9 is a small molecule inducer of adult neural stem cell

adenosine A2A receptor antagonist with Ki of 2.2 nM in differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to experimental models of Parkinson's disease. dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor… Purity: 99.42% Purity: 98.01% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

70 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

ITI214 ITI214 free base Cat. No.: HY-12501A Cat. No.: HY-12501

Bioactivity: ITI-214 is a picomolar PDE1 inhibitor with excellent Bioactivity: ITI-214 (free base) is a picomolar PDE1 inhibitor with selectivity against other PDE family members and against a excellent selectivity against other PDE family members and panel of , receptors, transporters, and ion channels, against a panel of enzymes, receptors, transporters, and ion exhibits potent PDE1 inhibitory activity (Ki = 58 pM). channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). Purity: 99.97% Purity: 98.0% Clinical Data: Phase 1 Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Itopride hydrochloride J-147 (HSR803) Cat. No.: HY-B0732 Cat. No.: HY-13779

Bioactivity: hydrochloride is an AChE inhibitor Bioactivity: J-147 is a broad spectrum neuroprotective phenyl hydrazide (acetylcholinesterase) and D2DR inhibitor. compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF). IC50 value: 60-115 nM in vitro assay [1] Target: J-147 has been shown to promotes HT22 and… Purity: 99.95% Purity: 99.90% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg, 1 g, 5 g 5 mg, 10 mg, 50 mg

JDTic JDTic dihydrochloride Cat. No.: HY-10486 Cat. No.: HY-10487

Bioactivity: JDTic is a highly selective antagonist for the κ-opioid Bioactivity: JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptor; without affecting the μ- or δ-opioid receptors. receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

Purity: >98% Purity: 98.18% Clinical Data: Phase 1 Clinical Data: Phase 1 Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

JH-II-127 JJKK 048 Cat. No.: HY-16936 Cat. No.: HY-108613

Bioactivity: JH-II-127 is a highly potent, selective, and brain penetrant Bioactivity: JJKK 048 is an ultrapotent and highly selective inhibitor of LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for ( MAGL). LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. IC50 value: 2.2 n(LRRK2-G2019S), 6.6 nM(LRRK2-wild-type), 47.7 nM (LRRK2-A2016T) Target: LRRK2 JH-II-127 is a potent and… Purity: 98.66% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg, 100 mg

JMV 2959 JMV 2959 hydrochloride Cat. No.: HY-U00433 Cat. No.: HY-U00433A

Bioactivity: JMV 2959 is a secretagogue receptor type 1a ( Bioactivity: JMV 2959 hydrochloride is a growth hormone secretagogue

GHS-R1a) antagonist with an IC50 of 32 nM. receptor type 1a ( GHS-R1a) antagonist with an IC50 of 32±3

nM in LLC-PK 1 cells.

Purity: >98% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg

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JNJ-18038683 JNJ-31020028 Cat. No.: HY-19889 Cat. No.: HY-14450

Bioactivity: JNJ-18038683 is a 5-Hydroxytryptamine Type 7 ( 5-HT7) Bioactivity: JNJ-31020028 is a selective brain penetrant antagonist of receptor antagonist, with pK s of 8.19, 8.20 for rat and human neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; i pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 5-HT in HEK293 cells, respectively. 7 receptors.

Purity: >98% Purity: 96.74% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

JNJ-39758979 JNJ-40411813 Cat. No.: HY-101189 (ADX-71149) Cat. No.: HY-15748

Bioactivity: JNJ-39758979 is a selective, high-affinity histamine H4 Bioactivity: JNJ-40411813 is a novel positive allosteric modulator of the receptor antagonist with a K of 12.5 nM. metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 i nM. IC50 value: 147 nM(EC50) Target: mGlu2R JNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and… Purity: 98.01% Purity: 99.69% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

JNJ-42153605 JNJ-42165279 Cat. No.: HY-18162 Cat. No.: HY-19636

Bioactivity: JNJ-42153605 is a positive allosteric modulator of the Bioactivity: JNJ-42165279 is a FAAH inhibitor with IC50 of 70 ± 8 nM and

metabotropic glutamate 2 ( mGlu2) receptor with an EC50 313 ± 28 nM for hFAAH and rFAAH, respectively. of 17 nM.

Purity: 98.10% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

JNJ-46778212 JNJ-5207852 (VU 0409551) Cat. No.: HY-19559 Cat. No.: HY-12190

Bioactivity: JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric Bioactivity: JNJ-5207852 is a selective and potent histamine H3 modulator with an EC50 of 260 nM. receptor (H 3R) antagonist, with pKis of 8.9, 9.24 for rat

and human H 3R, respectively.

Purity: 99.24% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

JNJ-63533054 JNJ16259685 Cat. No.: HY-19838 Cat. No.: HY-100407

Bioactivity: JNJ-63533054 is a potent and selective agonist of hGPR139 with Bioactivity: JNJ16259685 is a selective antagonist of mGlu1 receptor, an EC50 = 16 nM. and inhibits the synaptic activation of mGlu1 in a

concentration-dependent manner with IC50 of 19 nM.

Purity: 99.51% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg

72 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

JTC-801 Jujuboside A Cat. No.: HY-13274 Cat. No.: HY-N0659

Bioactivity: JTC-801 is a selective opioid receptor-like1 (ORL1) receptor Bioactivity: Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, a Chinese herbal medicine used to treat and antagonist, binding to ORL1 receptor with a Ki value of 8.2nM. anxiety.

Purity: 99.20% Purity: 98.18% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg

JW 642 JYL 1421 Cat. No.: HY-12332 (SC 0030) Cat. No.: HY-100668

Bioactivity: JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) Bioactivity: JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 that displays IC50 values of 7.6, 14, and 3.7 nM for nM. inhibition of MAGL in mouse, rat, and membranes, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 250 mg, 500 mg

JZL 184 JZL195 Cat. No.: HY-15249 Cat. No.: HY-15250

Bioactivity: JZL 184 is a potent and selective inhibitor of MAGL with IC50 Bioactivity: JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL brain membranes respectively. respectively.

Purity: 97.73% Purity: 99.75% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

K 01-162 K-115 (K162) Cat. No.: HY-14533 (Ripasudil) Cat. No.: HY-15685

Bioactivity: K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with Bioactivity: K-115 is a specific inhibitor of ROCK, with IC50s of 19 and an EC50 of 80 nM. 51 nM for ROCK2 and ROCK1, respectively.

Purity: 99.12% Purity: 98.38% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Kainic acid Kassinin Cat. No.: HY-N2309 Cat. No.: HY-P0250

Bioactivity: is a potent agonist at excitatory amino acid Bioactivity: Kassinin is a peptide derived from the Kassina frog. It receptor subtypes in the CNS. belongs to tachykinin family of . It is secreted as a defense response, and is involved in neuropeptide signalling. Sequence: Asp-Val-Pro-Lys-Ser-Asp-Gln-Phe-Val-Gly-Leu-Met-NH2. Purity: 99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg

www.MedChemExpress.com 73

Ketanserin tartrate (R41468) Cat. No.: HY-10562 (R41468 tartrate) Cat. No.: HY-10562A

Bioactivity: Ketanserin is a selective 5-HT receptor antagonist. Bioactivity: Ketanserin tartrate is a selective 5-HT receptor antagonist.

Ketanserin also blocks hERG current ( IhERG) in a Ketanserin tartrate also blocks hERG current ( IhERG) in a

concentration-dependent manner ( IC50=0.11 μM). concentration-dependent manner ( IC50=0.11 μM).

Purity: 98.86% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 50 mg, 100 mg 50 mg, 100 mg

KF21213 KFM19 Cat. No.: HY-U00180 Cat. No.: HY-U00251

Bioactivity: KF21213 is a highly selective ligand for mapping CNS adenosine Bioactivity: KFM19 is a potent, selective Adenosine receptor ( A receptors. KF21213 shows a high affinity for the 2A A1-receptor) antagonist, with an IC50 of 50 nM.

adenosine A2A receptors ( Ki=3.0 nM).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Kinetensin Kinetin (Kinetensin (human)) Cat. No.: HY-P1255 (6-Furfuryladenine; N6-Furfuryladenine) Cat. No.: HY-N0160

Bioactivity: Kinetensin is a -like peptide isolated from Bioactivity: Kinetin (N6-furfuryladenine) belongs to a group of plant pepsin-treated human plasma. growth hormones involved in cell division, differentiation and other physiological processes.

Purity: >98% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

KR-33493 KU-32 Cat. No.: HY-100755 Cat. No.: HY-108248

Bioactivity: KR-33493 is a potent inhibitor of Fas-mediated cell death Bioactivity: KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can ( FAF1). protect against neuronal cell death.

Purity: 99.91% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

KW-6055 Cat. No.: HY-19085 (Quinurenic acid) Cat. No.: HY-100806

Bioactivity: KW-6055 is a benzylpyridine derivative and has anti-amnesic Bioactivity: Kynurenic acid, an endogenous metabolite, is a activity. broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also a selective ligand of the GPR35 receptor.

Purity: >98% Purity: 98.75% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

74 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Kynurenic acid sodium L-655708 Cat. No.: HY-107512 Cat. No.: HY-14426

Bioactivity: Kynurenic acid, an endogenous tryptophan metabolite, is a Bioactivity: L-655708 is a potent α5 subunit-selective GABAA receptor broad-spectrum antagonist targeting NMDA, glutamate, inverse agonist (Ki = 0.45 nM). α7 nicotinic acetylcholine receptor. Kynurenic acid is also a selective ligand of the GPR35 receptor.

Purity: 98.60% Purity: 98.60% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg

L-685458 L-701324 (L-685,458) Cat. No.: HY-19369 Cat. No.: HY-18698

Bioactivity: L-685458 is a potent inhibitor of Amyloid β-Protein precursor Bioactivity: L-701324 is an orally active and long acting anticonvulsant γ-secretase activity with IC50 of 17 nM, shows greater than with high affinity and selectivity for the glycine site on the 50-100-fold selectivity over other aspartyl proteases tested. NMDA receptor.

Purity: 99.78% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg 10 mg, 50 mg

L- L-APB (L-2-Aminopropionic acid) Cat. No.: HY-N0229 (L-AP 4) Cat. No.: HY-100781A

Bioactivity: L-Alanine is a non-essential amino acid, involved in sugar and Bioactivity: L-APB is a potent and specific agonist for the group III acid metabolism, increases immunity, and provides energy for mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu muscle tissue, brain, and central nervous system. 4, mGlu 8, mGlu 6 and mGlu 7 receptors, respectively.

Purity: 98.0% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 5 g

L-Asparagine ((-)-Asparagine; Agedoite; Altheine; Asn; L- Asparagine; Asparagine acid; Asparamide; …) Cat. No.: HY-N0667 ((S)-4-Amino-3-isoxazolidone; (S)-Cycloserine) Cat. No.: HY-B1122

Bioactivity: L-Asparagine is a non-essential amino acid that is involved in Bioactivity: L-cycloserine irreversibly inhibit GABA pyridoxal the metabolic control of cell functions in nerve and brain 5′-phosphate-dependent aminitransferase in E. coli, as well in tissue. the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo. Purity: 98.0% Purity: 99.50% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 100 mg 10 mg, 50 mg, 100 mg

L-DABA L-DOPA (L-2,4-Diaminobutyric acid) Cat. No.: HY-101414 (Levodopa; 3,4-Dihydroxyphenylalanine) Cat. No.: HY-N0304

Bioactivity: L-DABA (L-2,4-Diaminobutyric acid) is a week GABA Bioactivity: L-DOPA is a natural form of DOPA used in the treatment of

transaminase inhibitor with an IC50 of larger than 500 μM; Parkinson's disease. L-DOPA is the precursor of dopamine and exhibits antitumor activity in vivo and in vitro. product of . Target: Dopamine Receptor L-DOPA (L-3,4-dihydroxyphenylalanine) is a chemical that is made and used as part of the normal biology of humans, some… Purity: 98.0% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 200 mg, 1 g 100 mg

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L-Epinephrine L-Epinephrine Bitartrate ((-)-Epinephrine (+)-bitartrate ((-)-Epinephrine; L-Adrenaline; (-)-Adrenalin) Cat. No.: HY-B0447B salt; L-Adrenaline (+)-bitartrate salt) Cat. No.: HY-B0447A

Bioactivity: L-Epinephrine is a hormone secreted by the medulla of the Bioactivity: L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic adrenal glands. L-Epinephrine is an α-adrenergic and receptor agonist. L-Epinephrine is a hormone secreted by the β-adrenergic receptor agonist. medulla of the adrenal glands.

Purity: 99.0% Purity: 99.0% Clinical Data: Launched Clinical Data: Launched Size: 1 g, 5 g Size: 10mM x 1mL in DMSO, 1 g, 5 g

L-Glutamic acid monosodium salt L- reduced (Monosodium glutamate) Cat. No.: HY-14608A (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) Cat. No.: HY-D0187

Bioactivity: L-Glutamic acid monosodium salt (Monosodium glutamate) is an Bioactivity: L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) activator of mGlu1 receptor. is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

Purity: 98.0% Purity: 99.64% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 g, 5 g 100 mg, 500 mg

L-Hisidine L-Hyoscyamine Cat. No.: HY-N0832 (Daturine) Cat. No.: HY-N0471

Bioactivity: L-Hisidine is an essential amino acid for infants. L-Hisidine Bioactivity: L-Hyoscyamine is a chemical compound, a tropane alkaloid it is is an inhibitor of mitochondrial glutamine transport. the levo-isomer to atropine.

Purity: 99.94% Purity: 99.08% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 1 g 100 mg, 500 mg

L-JNKI-1 L- Cat. No.: HY-P0069A Cat. No.: HY-104026

Bioactivity: L-JNKI-1 is a cell-permeable peptide inhibitor specific for Bioactivity: L-Kynurenine is a metabolite of the amino acid L-tryptophan. JNK. L-Kynurenine is an aryl hydrocarbon receptor agonist.

Purity: >98% Purity: 99.40% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg 50 mg

L-Tyrosine L791943 Cat. No.: HY-N0473 Cat. No.: HY-U00254

Bioactivity: L-Tyrosine is a non-essential amino acid which can inhibit Bioactivity: L791943 is a potent, selective Phosphodiesterase-4 ( PDE4)

citrate synthase activity in the posterior cortex. inhibitor with an IC50 of 4.2 nM.

Purity: 99.01% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 200 mg, 500 mg

76 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Lamotrigine (LTG; BW430C) Cat. No.: HY-B0495 (AZD3293; LY3314814) Cat. No.: HY-100740

Bioactivity: (BW430C) is a novel anticonvulsant drug for Bioactivity: Lanabecestat (AZD3293) is a potent, highly permeable, orally inhibition of 5-HT and sodium channel Target: Sodium Channel active and blood-brain barrier penetrating BACE1 inhibitor

Lamotrigine stabilises presynaptic neuronal membranes by with a Ki of 0.4 nM. blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly… Purity: 99.94% Purity: 99.76% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Lasmiditan dihydrochloride (COL-144; LY573144) Cat. No.: HY-14861 (Dimebolin dihydrochloride) Cat. No.: HY-14537

Bioactivity: (COL-144; LY573144) is a high-affinity, highly Bioactivity: Latrepirdine dihydrochloride is a neuroactive compound with selective 5-HT1F receptor agonist(Ki=2.1 nM), compared with Ki antagonist activity at , α-adrenergic, and of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, serotonergic receptors. Latrepirdine stimulates amyloid respectively. precursor protein (APP) catabolism and amyloid-β ( Aβ) secretion. Purity: >98% Purity: 99.75% Clinical Data: Phase 3 Clinical Data: Launched Size: 2 mg, 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg

Lazabemide LDN-212320 (Ro 19-6327/000) Cat. No.: HY-14201 (LDN/OSU-0212320; LDN-0212320; OSU-0212320) Cat. No.: HY-12741

Bioactivity: (Ro 19-6327/000) is selective, reversible monoamine Bioactivity: LDN-212320(OSU-0212320) is a glutamate transporter EAAT2 oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 activator; enhances EAAT2 levels by > 6 fold at μM for MAO-B and MAO-A respectively). concentrations < 5 μM after 24 h.

Purity: 99.71% Purity: 96.72% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg

LDN-57444 dihydrochloride Cat. No.: HY-18637 (E4424) Cat. No.: HY-101609

Bioactivity: LDN-57444 is a reversible, competitive and site-directed Bioactivity: Lesopitron dihydrochloride is a full and selective 5-HT1A inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with receptor agonist with IC of 125 nM in rat hippocampal an IC of 0.88 μM and a K of 0.40 μM; LDN-57444 also 50 50 i membranes. suppresses UCH-L3 activity, with an IC50 of 25 μM. Purity: 97.73% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

Leuprorelin Levalbuterol tartrate (Leuprolide) Cat. No.: HY-12553 ( tartrate) Cat. No.: HY-17457

Bioactivity: Leuprolide is an agonist at pituitary GnRH receptors. Bioactivity: Levosalbutamol tartrate(levalbuterol) is the R-enantiomer of the short-acting β2-adrenergic receptor agonist .

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10 mg, 50 mg

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Levamisole hydrochloride ((-)-Tetramisole hydrochloride) Cat. No.: HY-13666 (UCB L059) Cat. No.: HY-B0106

Bioactivity: Hcl is an and immunomodulator Bioactivity: Levetiracetam(UCB L059) is a novel anticonvulsant with belonging to a class of synthetic imidazothiazole derivatives. antihyperalgesic efficacy in inflammatory pain. Target: Calcium Channel Levetiracetam is used to control some types of seizures in patients with epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as… Purity: 99.96% Purity: 96.28% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g, 10 g 50 mg, 100 mg, 500 mg

Levobetaxolol hydrochloride hydrochloride ((S)- hydrochloride; AL-1577A) Cat. No.: HY-B0381B Cat. No.: HY-101631

Bioactivity: hydrochloride is a beta-adrenergic receptor Bioactivity: Levophacetoperane inhibits in vitro in a competitive manner, inhibitor (), used to lower the pressure in the norepinephrin uptake and dopamine uptake. eye in treating conditions such as glaucoma.

Purity: 98.11% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 mg 10 mg, 50 mg, 100 mg

Levosulpiride LH secretion antagonist 1 (S-(-)-) Cat. No.: HY-B1059 Cat. No.: HY-U00334

Bioactivity: is the (S)-enantiomer of sulpiride, which is a Bioactivity: LH secretion antagonist 1 is an antagonist of luteinising D2 receptor a antagonist, an atypical antipsychotic drug of hormone secretion, and may be used as an analgesic. the benzamide class.

Purity: 99.99% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

Lidanserin Lintopride (ZK-33839) Cat. No.: HY-101815 Cat. No.: HY-U00121

Bioactivity: is a drug which acts as a combined 5-HT2A and Bioactivity: Lintopride is a 5HT4 antagonist with moderate 5HT3 antagonist properties. α1-adrenergic receptor antagonist.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Lipid peroxidation inhibitor 1 Liquiritigenin Cat. No.: HY-U00319 (4',7-Dihydroxyflavanone) Cat. No.: HY-N0377

Bioactivity: Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor Bioactivity: Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis,

with an IC50 of 0.07 μM. is a highly selective estrogen receptor β ( ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.

Purity: >98% Purity: 99.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

78 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

LM22A-4 LM22B-10 Cat. No.: HY-100673 Cat. No.: HY-104047

Bioactivity: LM22A-4 is a specific agonist of receptor B, Bioactivity: LM22B-10 is an activator of TrkB/TrkC receptor, used for neurological disease research. and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.

Purity: 98.0% Purity: 98.81% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

LNK754 hydrochloride Cat. No.: HY-U00401 (α-Lobeline hydrochloride; L-Lobeline hydrochloride) Cat. No.: HY-B0979

Bioactivity: LNK754 is a farnesyltransferase inhibitor, used for the Bioactivity: Lobeline hydrochloride, a nicotinic receptor agonist, acting treatment of cancer and Alzheimer's disease. as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.

Purity: >98% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in Water, 100 mg, 500 mg

Lofexidine hydrochloride dihydrochloride (Baq-168; MDL-14042) Cat. No.: HY-B1052 (KB-2796) Cat. No.: HY-B0768A

Bioactivity: hydrochloride is an α2A-adrenergic receptor Bioactivity: Lomerizine dihydrochloride is an antagonist of L- and T-type agonist, commonly used to alleviate the physical symptoms of voltagegated calcium channels. and other types of opioid withdrawal.

Purity: >98% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 500 mg Size: 10mM x 1mL in DMSO, 50 mg

Loperamide hydrochloride Cat. No.: HY-B0418A Cat. No.: HY-19371

Bioactivity: HCl is an opioid-receptor agonist used as Bioactivity: Lorediplon is a novel non-benzodiazepine, hypnotic drug acting long-acting synthetic antidiarrheals. Target: Opioid Receptor as a GABAA receptor modulator, differentially active at the Loperamide is an effective therapy for a variety of diarrheal alpha1-subunit, associated with promoting sleep. syndromes. Loperamide is generally well tolerated at recommended nonprescription doses, with the most common side… Purity: 99.69% Purity: 99.78% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

Loxapine succinate Cat. No.: HY-17390 Cat. No.: HY-17390A

Bioactivity: Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic Bioactivity: Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. agent.

Purity: 99.86% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 100 mg, 500 mg

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LP-211 LRRK2-IN-1 Cat. No.: HY-111455 Cat. No.: HY-10875

Bioactivity: LP-211 is a selective and blood−brain barrier penetrant Bioactivity: LRRK2-IN-1 is a potent and selective LRRK2 inhibitor 5-HT receptor agonist, with a K of 0.58 nM, with high 7 i with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and

selectivity over 5-HT 1A receptor (K i, 188 nM) and D 2 LRRK2 (WT), respectively.

receptor (K i, 142 nM). Purity: 99.66% Purity: 99.38% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg 10 mg, 50 mg, 100 mg

LTI-291 Lu AE58054 Cat. No.: HY-104038 () Cat. No.: HY-14338

Bioactivity: LTI-291 is an activator of glucocerebrosidase ( Gcase) Bioactivity: Lu AE58054 is an in-vitro potency and selectivity, in-vivo extracted from patent WO 2017192841 A1. binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM.

Purity: 98.09% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Lu AE58054 Hydrochloride Lu AF21934 (Idalopirdine Hydrochloride) Cat. No.: HY-14338A Cat. No.: HY-100366

Bioactivity: Lu AE58054 hydrochloride is an in-vitro potency and Bioactivity: Lu AF21934 is a selective and brain-penetrant mGlu4 selectivity, in-vivo binding affinity and effect of the receptor positive allosteric modulator with an IC50 of 500 nM 5-HT(6)R antagonist with a Ki value of 0.83 nM. IC50 Value: for human mGlu4. 0.83 nm [1] Target: 5-HT(6)R in vitro: Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a… Purity: 99.17% Purity: 98.76% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Tosylate (ITI-007) Cat. No.: HY-19733 Cat. No.: HY-B0032A

Bioactivity: Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki = Bioactivity: Lurasidone is an antagonist of both dopamine D2 and 0.54 nM), a partial agonist of presynaptic D2 receptors and an 5-HT with IC s of 1.68 and 0.495 nM, respectively. antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a 7 50 Lurasidone is also a partial agonist of 5-HT receptor with SERT blocker (Ki = 61 nM). IC50 value: 0.54 nM (Ki, for 5-HT2A 1A

receptor ) Target: 5-HT2A receptor Lumateperone also possesses… an IC50 of 6.75 nM. Purity: 99.21% Purity: >98% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Lurasidone Hydrochloride Lurasidone Metabolite 14283 hydrochloride (SM-13496) Cat. No.: HY-B0032 Cat. No.: HY-G0001A

Bioactivity: Lurasidone is an antagonist of both dopamine D2 and Bioactivity: Lurasidone Metabolite 14283 hydrochloride is a major active 5-HT with IC s of 1.68 and 0.495 nM, respectively. metabolite of Lurasidone. Lurasidone is a FDA approved drug 7 50 for the treatment of schizophrenia. Lurasidone is also a partial agonist of 5-HT1A receptor with

an IC50 of 6.75 nM. Purity: 99.87% Purity: 99.06% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mg, 50 mg, 100 mg, 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg

80 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Lusaperidone Luteinizing Hormone Releasing Hormone (LH-RH), human (R107474) Cat. No.: HY-U00117 Cat. No.: HY-P1500

Bioactivity: Lusaperidone (R107474) is an α2 adrenergic receptor antagonist Bioactivity: Luteinizing Hormone Releasing Hormone (LH-RH), human is hypothalamic neuropeptide which plays a key role in the with Kis of 0.13 and 0.15 nM for α2A and α2C, respectively. control of reproductive functions.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 25 mg

LX-1031 LX1606 Cat. No.: HY-13041 () Cat. No.: HY-13055A

Bioactivity: LX-1031 is a potent, orally available tryptophan Bioactivity: LX1606 is a novel, orally-delivered inhibitor of tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) hydroxylase that reduces serotonin production. synthesis peripherally.

Purity: 98.71% Purity: 99.68% Clinical Data: Phase 2 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

LX1606 Hippurate LX2343 (Telotristat etiprate) Cat. No.: HY-13055 Cat. No.: HY-111383

Bioactivity: LX1606 Hippurate is a novel, orally-delivered inhibitor of Bioactivity: LX2343 is a BACE1 with an IC50 value of that reduces serotonin production. 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K

inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance. Purity: 99.87% Purity: 99.86% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

LY 344864 LY 344864 hydrochloride Cat. No.: HY-13788 Cat. No.: HY-13788B

Bioactivity: LY344864 is a selective receptor agonist with an affinity of 6 Bioactivity: LY 344864 hydrochloride is a selective 5-HT1F agonist with a nM (Ki) at the recently cloned 5-HT1F receptor. IC50 Value: 6 Ki of 6 nM. nM (Ki) [1] Target: 5-HT1F LY344864 possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined [1]. in vitro: he 5-HT1A, 5-HT1B and… Purity: 99.75% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg

LY 344864 racemate LY-411575 Cat. No.: HY-13788C Cat. No.: HY-50752

Bioactivity: LY 344864 racemate is a 5-HT1F receptor agonist extracted Bioactivity: LY-411575 is a potent γ-secretase inhibitor with IC50 of from patent US 5708187 A. 0.078 nM/0.082 nM (membrane/cell-based), and also inhibits

Notch S3 cleavage with IC50 of 0.39 nM.

Purity: 98.88% Purity: 98.71% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 81

LY-411575 isomer 1 LY-411575 isomer 2 Cat. No.: HY-50752A Cat. No.: HY-50752B

Bioactivity: LY-411575 isomer 1 is an isomer of LY411575, which is a potent Bioactivity: LY-411575 isomer 2 is an isomer of LY411575, which is a potent γ-secretase inhibitor. γ-secretase inhibitor.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg 1 mg

LY-411575 isomer 3 LY2119620 Cat. No.: HY-50752C Cat. No.: HY-15885

Bioactivity: LY-411575 isomer 3 is an isomer of LY411575, which is a potent Bioactivity: LY2119620 is a high-affinity muscarinic M2/M4 receptor γ-secretase inhibitor. agonist.

Purity: >98% Purity: 99.74% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

LY2183240 LY2795050 Cat. No.: HY-10865 Cat. No.: HY-15708

Bioactivity: LY2183240 is a novel and highly potent blocker of Bioactivity: LY2795050 is a novel selective κ-opioid Receptor (KOR) uptake (IC50 = 270 pM). LY2183240 inhibits fatty acid amide antagonist (IC50=0.72 nM) and has the potential as a PET hydrolase (FAAH) activity (IC50 = 12.4 nM). IC50: 270 pM tracer to image KOR in vivo. IC50 Value: 0.72 nM (κ-opioid (anandamide uptake); 12.4 nM (FAAH) Target: FAAH; Anandamide Receptor); 25.8 nM (κ-opioid) [1] Target: κ-opioid Receptor in uptake Following i.p. administration in rats, LY2183240… vitro: LY2795050 displays full antagonist activity and high… Purity: 99.07% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

LY2811376 LY2828360 Cat. No.: HY-10472 Cat. No.: HY-16642A

Bioactivity: LY2811376 is the first orally available non-peptidic Bioactivity: LY2828360 is a slowly acting but efficacious G protein-biased

β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, cannabinoid (CB2) agonist, inhibiting cAMP accumulation and

that acts to decrease Aβ secretion with EC50 of 300 nM, and activating ERK1/2 signaling. demonstrates to have 10-fold selectivity towards BACE1 o… Purity: 99.79% Purity: >98% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

LY2886721 LY2979165 Cat. No.: HY-13240 Cat. No.: HY-13239

Bioactivity: LY2886721 is an BACE inhibitor used for the treatment of Bioactivity: LY2979165 is a mGlu2 agonist, which is a novel potent agent Alzheimer's Disease. that is used as anti-.

Purity: 99.67% Purity: 98.0% Clinical Data: Phase 2 Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in water, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

82 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

LY310762 LY334370 Cat. No.: HY-13527 Cat. No.: HY-103107

Bioactivity: LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, Bioactivity: LY334370 is a selective 5-HT1F receptor agonist with a Ki of having a weaker affinity for 5-HT1B receptor. 1.6 nM.

Purity: 98.97% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

LY341495 LY354740 Cat. No.: HY-70059 (; Eglumetad) Cat. No.: HY-18941

Bioactivity: LY341495 is a metabotropic glutamate receptor (mGluR) Bioactivity: LY354740 is a highly potent and selective group II (mGlu2/3)

antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, receptor agonist with IC50s of 5 and 24 nM on transfected mGluR-3, mGluR-8, respectively. human mGlu2 and mGlu3 receptors, respectively.

Purity: 98.95% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 2 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg

LY404039 LY450108 Cat. No.: HY-50906 Cat. No.: HY-10935

Bioactivity: LY404039 is an inhibitor for mGluR1(Ki=149 nM) and mGluR2(Ki= Bioactivity: LY450108 is an 92 nM), which can also inhibit dopamine receptor. IC50 alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid Value:149 nM(Ki for mGlu2); 92 nM(Ki for mGlu3)[1] Target: (AMPA) receptor potentiator. IC50 value: Target: AMPA mGluR1; mGluR2 Metabotropic glutamate (mGlu) receptors have receptors mediate most of the excitatory neurotransmission and been shown to mediate a number of behaviors including… play a key role in in the mammalian… Purity: 98.0% Purity: 99.51% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

Macelignan mAChR-IN-1 ((+)-Anwulignan; Anwuligan) Cat. No.: HY-N0064 Cat. No.: HY-12426

Bioactivity: Macelignan(Anwuligan) is a natural compound isolated from Bioactivity: mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) Myristica fragrans Houtt; possesses therapeutic potentials antagonist with IC50 of 17 nM. against neurodegenerative diseases with oxidative stress and neuroinflammation.

Purity: 99.85% Purity: 99.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

MAFP (Methyl Arachidonyl Fluorophosphonate) Cat. No.: HY-103334 Cat. No.: HY-N0163

Bioactivity: MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, Bioactivity: Magnolol, a natural isolated from the stem bark of active-site directed and irreversible inhibitor of cPLA2 and Magnolia officinalis, is a dual agonist of both RXRα and

iPLA2. MAFP is also a potent irreversible inhibitor of PPARγ, with EC50 values of 10.4 µM and 17.7 µM, anandamide amidase. respectively.

Purity: 98.0% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 27 mM * 500 uL in Methyl Acetate, Size: 10mM x 1mL in DMSO, 27 mM * 100 uL in Methyl Acetate, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 83

Malathion MAO-B-IN-1 Cat. No.: HY-B0943 Cat. No.: HY-U00343

Bioactivity: is an parasympathomimetic which Bioactivity: MAO-B-IN-1 is an inhibitor of , used binds irreversibly to cholinesterase, is an insecticide of for the research of neurological diseases. relatively low human .

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

MAO-IN-1 hydrochloride Cat. No.: HY-U00015 Cat. No.: HY-B0444

Bioactivity: MAO-IN-1 is a monoamine oxidase B ( MAO B) inhibitor with Bioactivity: Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. Target: Others an IC50 of 20 nM. Maprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the… Purity: >98% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

MARK-IN-1 MARK-IN-2 Cat. No.: HY-101933 Cat. No.: HY-101934

Bioactivity: MARK-IN-1 is a potent microtubule affinity regulating kinase ( Bioactivity: MARK-IN-2 is a potent microtubule affinity regulating kinase (

MARK) inhibitor with an IC50 of <0.25 nM. MARK) inhibitor with an IC50 of 5 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 250 mg, 500 mg

Maropitant Mas7 Cat. No.: HY-10053 (Mastoparan 7) Cat. No.: HY-P0258

Bioactivity: is a neurokinin (NK1) receptor antagonist. IC50 Bioactivity: Mas7, a structural analogue of mastoparan, is an activator of value: Target: NK1 receptor Maropitant is the first NK1 heterotrimeric Gi proteins and its downstream effectors. receptor antagonist developed to treat and prevent emesis in Sequence: dogs. Treatment with 1 mg/kg Maropitant citrate, significantly Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Ala-Leu-Leu-NH2. reduced the size of ulcerative dermatitis (UD) lesions in… Purity: 99.00% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 2 mg, 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg, 25 mg

Mavoglurant MDA 19 (AFQ056) Cat. No.: HY-15257 Cat. No.: HY-15451

Bioactivity: is a structurally novel, non-competitive mGlu5 Bioactivity: MDA 19 is a selective human CB2 receptor agonist with Ki of receptor antagonist, has an IC50 of 30 nM in a functional 43.3 nM. assay with human mGluR5.

Purity: 99.74% Purity: 99.56% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

84 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

MDL 105519 MDL-29951 Cat. No.: HY-15085 Cat. No.: HY-16312

Bioactivity: MDL 105519 is a potent and selective antagonist of glycine Bioactivity: MDL-29951 is a novel glycine antagonist of NMDA receptor binding to the NMDA receptor. 3 activation, with Ki of 0.14 μM for [ H]glycine binding in vitro and in vivo.

Purity: 98.60% Purity: 98.50% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

Meclizine dihydrochloride hydrochloride (Meclozine dihydrochloride; NSC28728) Cat. No.: HY-B0349 Cat. No.: HY-17555

Bioactivity: is a histamine H1 receptor antagonist used to treat Bioactivity: Meclofenoxate hydrochloride, an ester of nausea and motion sickness Target: Histamine H1 Receptor (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown Meclizine is a histamine H1 receptor antagonist used to treat to improve memory, have a mentally stimulating effect, and nausea and motion sickness, possesses anticholinergic, central improve general cognition. nervous system depressant, and local anesthetic effects [1].… Purity: 99.97% Purity: 95.90% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 5 g 100 mg

Medetomidine Medetomidine hydrochloride Cat. No.: HY-17034 (MPV785) Cat. No.: HY-17034B

Bioactivity: Medetomidine(Domtor) is a potent, highly selective Bioactivity: Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for receptor, which is used in veterinary medicine for its α2- and α1-adrenoceptors respectively). analgesic and sedative properties.

Purity: 99.88% Purity: 99.49% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 10 mg, 50 mg

Mefexamide Melanin Concentrating Hormone, salmon Cat. No.: HY-B0950 (MCH (salmon)) Cat. No.: HY-P1525

Bioactivity: is a particular psychostimulant. Bioactivity: Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 100 mg Size: 500u g, 1 mg, 5 mg

Melanotan (MT)-II Melatonin Cat. No.: HY-P0267 (N-Acetyl-5-methoxytryptamine) Cat. No.: HY-B0075

Bioactivity: Melanotan (MT)-II, a synthetic Bioactivity: Melatonin is a hormone made by the pineal gland that can agonist, is an injectable used to promote activates . Melatonin plays a role in tanning. Sequence: Ac-{Nle}-Asp-His-D-Phe-Arg-Trp-Lys-NH2, sleep and possesses important antioxidative and (27)-lactam. anti-inflammatory properties.

Purity: 99.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

www.MedChemExpress.com 85

Memantine hydrochloride MEN 15596 Cat. No.: HY-B0365A (Ibodutant) Cat. No.: HY-14770

Bioactivity: , an derivative with low to Bioactivity: MEN 15596 is a potent and selective tachykinin NK2 receptor moderate-affinity for NMDA receptors, inhibit CYP2B6 and antagonist with a pKi of 10.1. CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.. Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent,… Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 g, 5 g

MEN11467 Cat. No.: HY-U00207 Cat. No.: HY-B1283

Bioactivity: MEN11467 is a selective and orally- effective peptidomimetic Bioactivity: Mephenesin is an NMDA receptor antagonist, is a centrally

tachykinin NK1 receptor antagonist. acting muscle relaxant.

Purity: >98% Purity: 99.20% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g

Mepivacaine hydrochloride maleate Cat. No.: HY-B0517A (Pyrilamine maleate) Cat. No.: HY-B1281

Bioactivity: is a tertiary amine used as a local anesthetic. Bioactivity: Mepyramine maleate, a first generation antihistamine, is an

antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor,

respectively, and a pKd of 9.4 for H1 receptor. Purity: 99.83% Purity: 99.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 100 mg

Metaxalone (AHR438; NSC170959) Cat. No.: HY-B0678 Cat. No.: HY-B1033

Bioactivity: (AHR438;NSC170959) is a muscle relaxant used to Bioactivity: Metergoline is a psychoactive drug of the ergoline chemical relax muscles. class which acts as a ligand for various serotonin and dopamine receptors.

Purity: 99.75% Purity: 98.62% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 50 mg, 100 mg

Methiothepin mesylate Methoxy-PEPy ( mesylate; Ro 8-6837 mesylate) Cat. No.: HY-107836 Cat. No.: HY-12510

Bioactivity: Methiothepin mesylate is a potent and non-selective 5-HT2 Bioactivity: Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. receptor antagonist, with p Kds of 7.10 (5-HT 1A), 7.28

(5HT 1B), 7.56 (5HT 1C), 6.99 (5HT 1D), 7.0 (5-HT 5A), 7.8

(5-HT 5B), 8.74 (5-HT 6), and 8.99 (5-HT 7), and p Kis… Purity: 99.32% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

86 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Methysticin Metofenazate (DL-Methysticin; (±)-Methystici) Cat. No.: HY-N0922 (Methophenazine) Cat. No.: HY-100263

Bioactivity: Methysticin is a major in extract to induce Bioactivity: Metofenazate is a selective calmodulin inhibitor. CYP1A1.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

Mianserin hydrochloride (Mianserine) Cat. No.: HY-B0188 Cat. No.: HY-B0188A

Bioactivity: Mianserin is a H1 receptor inverse agonist and is a Bioactivity: Mianserin hydrochloride is a H1 receptor inverse agonist and psychoactive agent of the tetracyclic antidepressant. is a psychoactive agent of the tetracyclic antidepressant. Target: H1 receptor Mianserin is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic… Purity: >98% Purity: 99.79% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg

Mibampator (LY451395) Cat. No.: HY-10934 ((±)-Midodrin) Cat. No.: HY-12749

Bioactivity: LY451395() is a potent and highly selective Bioactivity: Midodrine is an α1-receptor agonist, for the treatment of potentiator of the AMPA receptors. IC50 value: Target: AMPA dysautonomia and . receptor potentiator in vitro: in vivo: Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo… Purity: 99.47% Purity: >98% Clinical Data: Phase 2 Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Midodrine hydrochloride Miglustat ((±)-Midodrine hydrochlorid) Cat. No.: HY-12749A (N-Butyldeoxynojirimycin; NB-DNJ; OGT918) Cat. No.: HY-17020

Bioactivity: Midodrine hydrochloride is an α1-receptor agonist, for the Bioactivity: Miglustat(OGT918) is an inhibitor of glucosylceramide treatment of dysautonomia and orthostatic hypotension. synthase, primarily to treat Type I Gaucher disease (GD1).

Purity: >98% Purity: >98% Clinical Data: Phase 4 Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 5 mg, 10 mg

Miglustat hydrochloride (N-Butyldeoxynojirimycin, Hydrochloride; NB-DNJ hydrochloride; …) Cat. No.: HY-17020A Cat. No.: HY-B0168

Bioactivity: Miglustat hydrochloride is an inhibitor of glucosylceramide Bioactivity: Milnacipran is a serotonin-norepinephrine reuptake inhibitor synthase, primarily to treat Type I Gaucher disease (GD1). (SNRI) used in the clinical treatment of fibromyalgia.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg

www.MedChemExpress.com 87

Milnacipran (1S-cis) hydrochloride Milnacipran hydrochloride ( hydrochloride; F-2695 hydrochloride) Cat. No.: HY-B0168B Cat. No.: HY-B0168A

Bioactivity: Milnacipran (1S-cis) hydrochloride is a Bioactivity: Milnacipran hydrochloride is a serotonin-norepinephrine serotonin-norepinephrine reuptake inhibitor (SNRI), used in reuptake inhibitor (SNRI) used in the clinical treatment of the clinical treatment of fibromyalgia. fibromyalgia.

Purity: 99.96% Purity: 99.40% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 10 mg, 50 mg, 100 mg

Minaprine dihydrochloride Cat. No.: HY-B0884 Cat. No.: HY-B0884A

Bioactivity: Minaprine is a reversible inhibitor of MAO-A; weakly inhibit Bioactivity: Minaprine 2Hcl is a reversible inhibitor of MAO-A; weakly acetylcholinesterase; an antidepressant for treatment of inhibit acetylcholinesterase; an antidepressant for treatment depression. of depression.

Purity: 99.82% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg 100 mg

Mirabegron Miridesap (YM178) Cat. No.: HY-14773 (CPHPC; Ro63-8695; GSK2315698) Cat. No.: HY-101861

Bioactivity: is a selective β3-adrenoceptor agonist with Bioactivity: Miridesap is a ligand for serum amyloid P component ( EC of 22.4 nM. SAP) and intends to inhibit and dissociate SAP binding to 50 amyloid fibrils and tangles.

Purity: 99.08% Purity: 98.05% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg

Mirogabalin besylate (DS5565) Cat. No.: HY-12650 (DS 5565 besylate) Cat. No.: HY-108006

Bioactivity: Mirogabalin (DS-5565) is a novel, preferentially selective Bioactivity: Mirogabalin besylate is a selective and orally available α2δ-1 ligand characterized by high potency and selectivity to ligand for the α2δ subunit of voltage-gated calcium channels,

the α2δ-1 subunit of voltage-sensitive calcium channel with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human complexes in the CNS. α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.

Purity: 99.31% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Mirtazapine MIV-247 (Org3770; 6-Azamianserin) Cat. No.: HY-B0352 Cat. No.: HY-112583

Bioactivity: is a potent tetracyclic antidepressant. Bioactivity: MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

Purity: 99.77% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 100 mg, 200 mg, 500 mg

88 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

MK-0249 MK-0752 Cat. No.: HY-U00076 Cat. No.: HY-10974

Bioactivity: MK-0249 is a potent histamine H3 receptor antagonist, with Bioactivity: MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Ki of 1.7 nM for human H3.

Purity: >98% Purity: 98.87% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

MK-0974 MK-3207 () Cat. No.: HY-32709 Cat. No.: HY-10301

Bioactivity: MK-0974 is a highly potent, selective, and orally bioavailable Bioactivity: MK-3207 is a potent and orally bioavailable CGRP receptor

CGRP receptor antagonist with Ki values of 0.77 nM and 1.2 antagonist (IC50= 0.12 nM; Ki value= 0.024 nM); highly nM for human and rhesus CGRP receptors, respectively, but selective versus human AM1, AM2, CTR, and AMY3. displays >1500-fold lower affinity for the canine and rat receptors. Purity: 99.07% Purity: >98% Clinical Data: Phase 3 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg

MK-3207 Hydrochloride MK-3328 Cat. No.: HY-10302 Cat. No.: HY-100275

Bioactivity: MK-3207 (Hydrochloride) is a potent and orally bioavailable Bioactivity: MK-3328 is a β-Amyloid PET ligand, which exhibits high CGRP receptor antagonist with IC of 0.12 nM and K of 50 i binding potency with an IC50 of 10.5 nM. 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.

Purity: 98.07% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

MK-3697 MK-6096 Cat. No.: HY-12301 () Cat. No.: HY-15653

Bioactivity: MK-3697 is an isonicotinamide small molecule, acting as a Bioactivity: MK-6096(Filorexant) is an orally bioavailable potent and potent and selective Orexin 2 receptor antagonist with Ki = selective reversible antagonist of OX1 and OX2 receptor(<3 0.95 nM. nM in binding). IC50 value: < 3 nM(binding Ki) [1] Target: Orexin receptor antagonist in vitro: In radioligand binding and functional cell based assays MK-6096 demonstrated potent… Purity: 99.19% Purity: 98.95% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

MK-7622 MK-8998 (M1 receptor modulator) Cat. No.: HY-15618 Cat. No.: HY-101096

Bioactivity: MK-7622 is a muscarinic M1 receptor positive allosteric Bioactivity: MK-8998 is a potent and selective antagonist of the T-type modulator. Target: M1 receptor MK-7622 is useful in the calcium channel. treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. Purity: 98.37% Purity: 99.82% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

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ML204 ML213 Cat. No.: HY-12949 Cat. No.: HY-101843

Bioactivity: ML204 is a novel potent antagonist that selectively modulates Bioactivity: ML213 is a selective activator of Kv7.2 and Kv7.4 channels, native TRPC4/C5 ion channels. enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.

Purity: 98.31% Purity: 99.53% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ML218 ML221 Cat. No.: HY-103309 Cat. No.: HY-103254

Bioactivity: ML218 is a selective T-type calcium channel inhibitor with Bioactivity: ML221 is a potent apelin (APJ) functional antagonist,

IC50s of 270 and 310 nM for Cav3.3 and Cav3.2 in inhibiting apelin-13-mediated activation of APJ, with IC50s of electrophysiology assay, respectively. 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin

assay, and EC80 of 10 nM in both assays. Purity: 99.49% Purity: 99.25% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ML314 ML335 Cat. No.: HY-16639 Cat. No.: HY-104005

Bioactivity: ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); Bioactivity: ML335 is a selective activator of both TREK-1 and TREK-2. showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.

Purity: 99.72% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ML402 MLE-4901 Cat. No.: HY-104027 (AZD4901; AZ12472520; AZD2624; pavinetant) Cat. No.: HY-14432

Bioactivity: ML402 is a selective TREK-1 activator. Bioactivity: MLE-4901 is a neurokinin-3 receptor ( NK3R) antagonist.

Purity: 99.88% Purity: 99.74% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

MLi-2 Cat. No.: HY-100411 (Ro111163) Cat. No.: HY-B0534

Bioactivity: MLi-2 is an a potent, highly selective, orally available, Bioactivity: Moclobemide(Ro111163) is a reversible monoamine oxidase

brain penetrant inhibitor of LRRK2 with an IC50 of 0.76 nM. inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.

Purity: 99.66% Purity: 99.45% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 50 mg, 100 mg

90 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Modaline sulfate hydrochloride Cat. No.: HY-B1083 (MDL72974A) Cat. No.: HY-16677A

Bioactivity: Modaline Sulfate is a MAO inhibitor, used in the treatment of Bioactivity: Mofegiline Hcl (MDL72974A) is a potent and selective depression. enzyme-activated irreversible inhibitor of MAO-B; shows marked selectivity for the B form (IC50 = 680 and 3.6 nM for MAO-A and MAO-B, respectively.

Purity: 99.40% Purity: 97.19% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Moguisteine hydrochloride (BBR-2173) Cat. No.: HY-B0505 (EN-1733A) Cat. No.: HY-B1017

Bioactivity: Moguisteine(BBR-2173) is a novel peripheral non- Bioactivity: Molindone is a therapeutic antipsychotic, used in the antitussive drug. treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses.

Purity: 99.44% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 10 mg, 50 mg

Morroniside Cat. No.: HY-N0532 (TAK-370; AS-4370) Cat. No.: HY-B0189

Bioactivity: Morroniside has neuroprotective effect by inhibiting neuron Bioactivity: Mosapride is a gastroprokinetic agent that acts as a selective apoptosis and MMP2/9 expression. 5HT4 agonist.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 5 mg, 10 mg, 25 mg

Mosapride citrate (TAK-370 citrate; AS-4370 citrate) Cat. No.: HY-B0189A (BDF5895) Cat. No.: HY-B0374

Bioactivity: Mosapride citrate is a gastroprokinetic agent that acts as a Bioactivity: Moxonidine is a selective agonist at the imidazoline receptor selective 5HT4 agonist. subtype 1, used as antihypertensive agent.

Purity: 99.74% Purity: 99.91% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg, 100 mg

Moxonidine hydrochloride MPEP (BDF5895 hydrochloride) Cat. No.: HY-B0374A Cat. No.: HY-14609A

Bioactivity: Moxonidine Hydrochloride is a selective agonist at the Bioactivity: MPEP is a potent and highly selective non-competitive imidazoline receptor subtype 1, used as antihypertensive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a agent. positive allosteric modulator at mGlu4 receptors.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mg, 50 mg, 100 mg Size: 10 mg, 50 mg

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MPEP Hydrochloride MPTP hydrochloride Cat. No.: HY-14609 Cat. No.: HY-15608

Bioactivity: MPEP hydrochloride is a potent and highly selective Bioactivity: MPTP hydrochloride is a brain penetrant dopamine non-competitive antagonist at the mGlu5 receptor subtype with neurotoxin, inducing Parkinson’S Disease. IC50 of 36 nM.

Purity: 99.57% Purity: 99.62% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg, 100 mg

MRX-1024 MRZ 2-514 (D-Methionine) Cat. No.: HY-13694 Cat. No.: HY-101620

Bioactivity: MRX-1024 is an effective chemoprotective agent which can also Bioactivity: MRZ 2-514 is an antagonist of the -insensitive

inhibit the neuronal activity through GABAA receptor modulatory site of the NMDA receptor (glycineB), with Ki activation. of 33 μM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g

MS21570 MSDC 0160 Cat. No.: HY-112620 (Mitoglitazone; CAY10415) Cat. No.: HY-100550

Bioactivity: MS21570 is a selective GPR171 antagonist, with an IC50 of 220 Bioactivity: MSDC 0160 act as an insulin sensitizer and a modulator of nM. mitochondrial pyruvate carrier (MPC), a key controller of cellular metabolism that influences mTOR (mammalian target of rapamycin) activation. In Vitro: MSDC-0160 acts as insulin sensitizers without activating PPARγ. MSDC-0160 (10 μM)… Purity: 99.33% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

MTEP hydrochloride Myomodulin Cat. No.: HY-13206 Cat. No.: HY-P0268

Bioactivity: MTEP Hcl is a potent, selective and non-competitive mGlu5 Bioactivity: Myomodulin is a neuropeptide present in molluscs, insects, and antagonist with IC50 and Ki of 5 nM and 16 nM, respectively. gastropods. Sequence: Pro-Met-Ser-Met-Leu-Arg-Leu-NH2.

Purity: 99.73% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea N-Acetyl-5-hydroxytryptamine Cat. No.: HY-101708 (N-Acetylserotonin; Normelatonin; O-Demethylmelatonin) Cat. No.: HY-107854

Bioactivity: N-[(1R)-4-[(Aminoiminomethyl)amino]-1-[[[(1R)-1-(4-hydroxyphen Bioactivity: N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and yl)ethyl]amino]carbonyl]butyl]-α-phenylbenzeneacetamide is an that it can potently activate TrkB receptor. anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Size: 1 mg, 5 mg, 10 mg, 20 mg Size:

92 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

N-Acetyl-DL-phenylalanine N-Acetylcysteine amide (Afalanine) Cat. No.: HY-B1086 Cat. No.: HY-110256

Bioactivity: N-Acetyl-DL-phenylalanine is an antidepressive drug. Bioactivity: N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent.

Purity: 99.96% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 1 mg

N-type -1 N-[(4-Aminophenyl)methyl]adenosine Cat. No.: HY-100310 Cat. No.: HY-100130

Bioactivity: N-type calcium channel blocker-1 is an orally active analgesic Bioactivity: N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor agent which shows high affinity to functionally block N-type inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase.

calcium channels with an IC50 of 0.7 μM in the IMR32 assay.

Purity: >98% Purity: 98.68% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

N6-Cyclohexyladenosine N6-[2-(4-Aminophenyl)ethyl]adenosine (CHA) Cat. No.: HY-18939 (APNEA) Cat. No.: HY-18687

Bioactivity: N6-Cyclohexyladenosine is a selective A1 receptor agonist Bioactivity: N6-[2-(4-Aminophenyl)ethyl]adenosine is a potent, (EC50 = 8.2 nM). non-selective A3 adenosine receptor agonist.

Purity: 99.98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg, 100 mg

Naltrindole hydrochloride Cat. No.: HY-101177 (PRX 00023) Cat. No.: HY-14848

Bioactivity: hydrochloride is a highly potent and selective Bioactivity: Naluzotan is a novel, potent, and selective amidosulfonamide

non-peptide δ opioid receptor antagonist with a Ki of 0.02 nM. 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak + hERG K channel blocker, with IC 50 of 3800 nM. Purity: 99.68% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg

NAN-190 hydrobromide Cat. No.: HY-19818A (GR-85548A) Cat. No.: HY-B0197

Bioactivity: NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. Bioactivity: Naratriptan is a selective 5-HT1 receptor subtype agonist and NAN-190 is a selective antagonist of 5-HT1A. is a drug that is used for the treatment of migraine .

Purity: 98.31% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg, 50 mg, 100 mg, 200 mg

www.MedChemExpress.com 93

Naratriptan hydrochloride Naspm (GR-85548A hydrochloride) Cat. No.: HY-B0197A (1-Naphthylacetyl ) Cat. No.: HY-12506

Bioactivity: Naratriptan hydrochloride is a selective 5-HT1 receptor Bioactivity: Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of subtype agonist and is a triptan drug that is used for the Joro spider toxin, is a calcium permeable AMPA ( CP-AMPA) treatment of migraine headaches. receptors antagonist.

Purity: 99.68% Purity: 96.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

Naspm trihydrochloride Nav1.7 inhibitor (1-Naphthylacetyl spermine trihydrochloride) Cat. No.: HY-12506A Cat. No.: HY-13985

Bioactivity: Naspm (1-Naphthyl acetyl spermine) trihydrochloride, a Bioactivity: Nav1.7 inhibitor is a potent Nav1.7 inhibitor. synthetic analogue of Joro spider toxin, is a calcium permeable AMPA ( CP-AMPA) receptors antagonist.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Nav1.7-IN-2 NBI-98782 Cat. No.: HY-19366 ((+)-DTBZ; (+)-α-; (+)-α-DHTBZ) Cat. No.: HY-15793

Bioactivity: Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels Bioactivity: NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine (Nav), in particular Nav 1.7, with IC50 of 80 nM. transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.

Purity: >98% Purity: 98.36% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

NBI-98854 ((2R,3R,11bR)-rel-Dihydrotetrabenazine; NBQX (2R,3R,11bR)-rel-DHTBZ) Cat. No.: HY-15793A (FG9202) Cat. No.: HY-15068

Bioactivity: NBI-98854 is a potent, highly selective, VMAT2 inhibitor that Bioactivity: NBQX is a potent aminomethylphosphonic acid receptor is effective in regulating the levels of dopamine release (AMPAR) during nerve communication. antagonist with an IC50 of 0.7 ± 0.1 μM.

Purity: >98% Purity: 98.65% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Nefazodone hydrochloride (BMY-13754; MJ-13754-1) Cat. No.: HY-B1396 (DM9384; DZL-221) Cat. No.: HY-B0340

Bioactivity: hydrochloride is an antidepressant drug. Bioactivity: Nefiracetam is a GABAergic, cholinergic, and neuronal systems enhancer for Ro 5-4864-induced .

Purity: 99.71% Purity: 99.96% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 50 mg, 100 mg

94 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Nefopam hydrochloride Nelonicline (Fenazoxine hydrochloride) Cat. No.: HY-B1057 Cat. No.: HY-16748

Bioactivity: is a centrally-acting but non-opioid analgesic drug, Bioactivity: Nelonicline is a selective neuronal nicotinic receptor agonist. for the relief of moderate to severe pain.

Purity: 99.06% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 250 mg, 500 mg 10 mg, 50 mg

Nelotanserin Nemorexant (APD125) Cat. No.: HY-10559 (ACT-541468) Cat. No.: HY-109095

Bioactivity: is a potent 5-HT2A inverse agonist, a Bioactivity: Nemorexant is a potent antagonist extracted from patent WO2015083094A1, compound example 7, has IC50s of 2 moderately potent 5-HT2C partial inverse agonist and a weak nM and 3 nM for Ox1 receptor and Ox2 receptor, 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. respectively. Purity: 99.59% Purity: 99.47% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

NEO 376 methyl sulfate (SPI-376) Cat. No.: HY-101583 Cat. No.: HY-B1206

Bioactivity: NEO 376 is a selective modulator of 5-HT1 receptor, GABA Bioactivity: Neostigmine methyl sulfate is a reversible inhibitor of receptor and dopamine receptor, with anti-psychotic acetylcholinesterase, can not cross the blood-brain barrier. actively.

Purity: >98% Purity: 99.71% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg

NEP-In-1 Cat. No.: HY-U00294 (CID 6451149) Cat. No.: HY-16346

Bioactivity: NEP-IN-1 is a neutral endopeptidase ( NEP) inhibitor with Bioactivity: Netupitant (CID-6451149) is a highly potent and selective, orally active neurokinin-1 receptor antagonist with Ki of 0.95 IC50 of 2 nM for dNEP. nM. IC50 value: 0.95 nM (Ki) [1] Target: NK1 receptor in vitro: Netupitant also dose-dependently inhibited the SP response as expected from an NK1 receptor antagonist.… Purity: >98% Purity: 99.78% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Neu2000 Neurodegenerative Disorder-Targeting Compound 1 Cat. No.: HY-106408 Cat. No.: HY-U00362

Bioactivity: Neu2000 is an uncompetitive N-methyl-D-aspartate ( NMDA) Bioactivity: Neurodegenerative Disorder-Targeting Compound 1 is a receptor antagonist. carboxamide compound, used in the research of neurodegenerative disorders.

Purity: 99.09% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 95

Neurokinin A Neurokinin A(4-10) (α-Neurokinin; Neuromedin L; Substance K) Cat. No.: HY-P0197 Cat. No.: HY-P0236

Bioactivity: Neurokinin A acts via neurokinin 2 ( NK-2) receptor. Bioactivity: Neurokinin A (4-10) is a tachykinin NK2 receptor agonist. Sequence: His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2. Sequence: Asp-Ser-Phe-Val-Gly-Leu-Met-NH2.

Purity: 98.92% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg, 25 mg

Neurokinin B Cat. No.: HY-P0242 Cat. No.: HY-P0241

Bioactivity: Neurokinin B belongs to the tachykinin family of peptides. Bioactivity: Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide Neurokinin B binds a family of GPCRs—including neurokinin family in mammals. Sequence: receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2. effect. Sequence: Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-N…

Purity: >98% Purity: 98.11% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg, 25 mg

Neuromedin N Neuromedin U, rat ( (rat, mouse, porcine, canine)) Cat. No.: HY-P0079 (Neuromedin U (rat); Rat neuromedin U-23) Cat. No.: HY-P1238

Bioactivity: Neuromedin N is a potent modulator of dopamine D2 receptor Bioactivity: Neuromedin U, rat is a 23-amino acid brain-gut peptide. agonist binding in rat neostriatal membranes. Sequence: Neuromedin U (NMU), through its cognate receptor NMUR2 in the Lys-Ile-Pro-Tyr-Ile-Leu. central nervous system, regulates several important physiological functions, including energy balance, stress response, and . Purity: 99.73% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 5 mg, 10 mg, 25 mg

Neuromuscular Disorder-Targeting Compound 1 Neuromuscular-targeting compound 1 Cat. No.: HY-U00385 Cat. No.: HY-U00310

Bioactivity: Neuromuscular Disorder-Targeting Compound 1 is used in the Bioactivity: Neuromuscular-targeting compound 1, extracted from patent research of neuromuscular disorders such as symptoms of WO2009099594 A1, Paragraph 0100, is useful in treatment of fibromyalgia syndrome and chronic syndrome. neuromuscular diseases.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Neuronostatin-13 human Neuropathiazol Cat. No.: HY-P1373 Cat. No.: HY-10591

Bioactivity: Neuronostatin-13 human is a 13-amino acid peptide hormone Bioactivity: Neuropathiazol is a synthetic small molecule that induces encoded by the somatostatin gene and plays an important role neuronal differentiation of adult hippocampal neural in the regulation of hormonal and cardiac function. Sequence: progenitor cells. Leu-Arg-Gln-Phe-Leu-Gln-Lys-Ser-Leu-Ala-Ala-Ala-Ala-NH2.

Purity: 99.12% Purity: 97.85% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 5 mg, 50 mg

96 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Neuropeptide AF (93-110), Human (13-36), amide, human (Neuropeptide AF (human)) Cat. No.: HY-P1246 (Neuropeptide Y (13-36), human) Cat. No.: HY-P1480

Bioactivity: Neuropeptide AF (93-110), Human is an endogenous antiopioid Bioactivity: Neuropeptide Y (13-36), amide, human is a neuropeptide Y peptide. receptor agonist.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 500u g, 1 mg, 5 mg

Neuropeptide Y (29-64), amide, human Neuropeptide Y (29-64), amide, human TFA (Human neuropeptide Y (29-64)) Cat. No.: HY-P0198 Cat. No.: HY-P0198A

Bioactivity: Neuropeptide Y (29-64), amide, human is a biologically active Bioactivity: Neuropeptide Y (29-64), amide, human (TFA) is involved in 36-amino acid peptide. Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

Purity: >98% Purity: 95.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Neuropeptide Y(29-64) Neurotensin(8-13) Cat. No.: HY-P1601 Cat. No.: HY-P0251

Bioactivity: Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment Bioactivity: Neurotensin (8-13) is an active fragment of Neurotensin,. of Neuropeptide Y. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. Sequence: Arg-Arg-Pro-Tyr-Ile-Leu.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg, 25 mg

Neurotoxin Inhibitor NGP555 Cat. No.: HY-112722 Cat. No.: HY-108714

Bioactivity: Neurotoxin Inhibitor is a neurotoxin inhibitor. Bioactivity: NGP555 is a γ-secretase modulator.

Purity: >98% Purity: 98.64% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500 mg, 250 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

NHE3-IN-1 Cat. No.: HY-100325 Cat. No.: HY-B1199

Bioactivity: NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) Bioactivity: Nialamide is a non-selective, irreversible monoamine oxidase inhibitor extracted from patent WO 2011019784 A1. inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.

Purity: >98% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg

www.MedChemExpress.com 97

Nicardipine Hydrochloride (YC-93) Cat. No.: HY-12515 (YC-93 Hydrochloride) Cat. No.: HY-12515A

Bioactivity: Nicardipine(YC-93) is a calcium channel blocker that has been Bioactivity: Nicardipine Hcl(YC-93) is a calcium channel blocker that has widely used to control blood pressure in severe been widely used to control blood pressure in severe following events such as ischemic stroke, traumatic brain hypertension following events such as ischemic stroke, injury, and intracerebral hemorrhage. traumatic brain injury, and intracerebral hemorrhage.

Purity: >98% Purity: 99.85% Clinical Data: Launched Clinical Data: Launched Size: 1 g, 5 g Size: 10mM x 1mL in DMSO, 1 g, 5 g

Nicergoline Nicotiflorin Cat. No.: HY-B0702 Cat. No.: HY-N1475

Bioactivity: is an ergot derivative used to treat senile Bioactivity: Nicotiflorin is a flavonoid glycoside extracted from a dementia and other disorders with vascular origins. Target: traditional Chinese medicine Flos Carthami. Nicotiflorin Alpha-1A adrenergic receptor Nicergoline acts by inhibiting shows potent antiglycation activity and neuroprotection the postsynaptic alpha(1)-adrenoceptors on vascular smooth effects. muscle. This inhibits the vasoconstrictor effect of… Purity: 99.06% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 10 mg, 50 mg

Nicotinamide (Niacinamide; Nicotinic acid amide; Vitamin B3) Cat. No.: HY-B0150 (CIBA 2330Go) Cat. No.: HY-101684

Bioactivity: is a form of vitamin B3 that plays essential Bioactivity: Nitroxazepine is a tricyclic antidepressant (TCA) for the roles in cell physiology through facilitating NAD+ redox treatment of depression. Nitroxazepine acts as a homeostasis and providing NAD+ as a substrate to a class of serotonin-norepinephrine reuptake inhibitor. enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1. Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g, 5 g

NK-1 Antagonist 1 NKP608 Cat. No.: HY-106659 Cat. No.: HY-18006

Bioactivity: NK-1 Antagonist 1 is an antagonist of NK-1 receptor, used in Bioactivity: NKP608 is a non-peptidic derivative of 4-aminopiperidine which the research of NK-1 related diseases and conditions such as acts as a selective, specific and potent antagonist at the cough, overactive bladder, alcohol dependency and depression. neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.

Purity: >98% Purity: 99.34% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

NMDA NMDA-IN-1 (N-Methyl-D-aspartic acid) Cat. No.: HY-17551 Cat. No.: HY-12962

Bioactivity: NMDA is a specific agonist for NMDA receptor Bioactivity: NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with mimicking the action of glutamate, the neurotransmitter which Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities normally acts at that receptor. on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 50 mg, 100 mg

98 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

NMI 8739 Cat. No.: HY-101540 (Orphanin FQ) Cat. No.: HY-P0183

Bioactivity: NMI 8739 is a dopamine D2 autoreceptor agonist, which is Bioactivity: Nociceptin, a heptadecapeptide, is the endogenous ligand of an amine conjugate of the DHA carrier and the neurotransmitter the , acting as a potent anti-analgesic. dopamine. Sequence: Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys- Leu-Ala-Asn-Gln.

Purity: >98% Purity: 99.79% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg, 25 mg

Nomifensine maleate ((±)-Nomifensin) Cat. No.: HY-B1110 ((±)-Nomifensine maleat) Cat. No.: HY-B1110A

Bioactivity: Nomifensine is a norepinephrine-dopamine reuptake inhibitor, Bioactivity: Nomifensine maleate is a selective inhibitor of dopamine increases the amount of synaptic norepinephrine and dopamine uptake, used in adult attention deficit disorder. available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

Purity: 99.24% Purity: 98.14% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 50 mg, 100 mg

Nonivamide (Pseudocapsaicin; Pelargonic acid vanillylamide; Noopept Nonanoic acid vanillylamide) Cat. No.: HY-17568 (GVS-111; SGS-111; Omberacetam) Cat. No.: HY-17456

Bioactivity: Nonivamide is a

EC50 value of 5.1 mg/L in static toxicity tests. Russia and neighbouring countries as a nootropic. IC50 Value: Target: in vitro: Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites… Purity: 98.15% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg, 5 g 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Nordihydroguaiaretic acid hydrochloride (NDGA) Cat. No.: HY-N0198 (Desmethylamitriptyline hydrochloride) Cat. No.: HY-B1417

Bioactivity: Nordihydroguaiaretic acid is a 5-lipoxygenase ( 5LOX) ( Bioactivity: Nortriptyline hydrochloride is a tricyclic antidepressant used to relieve the symptoms of depression. IC50=8±3 μM) and tyrosine kinase inhibitor.

Purity: 99.78% Purity: 99.96% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 50 mg

NOT Receptor Modulator 1 Notoginsenoside R2 Cat. No.: HY-U00429 (20(S)-Notoginsenoside R2; Ginsenoside Ng-R2) Cat. No.: HY-N0909

Bioactivity: NOT Receptor Modulator 1 is a nuclear receptor NOT modulator Bioactivity: Notoginsenoside R2 is a newly isolated notoginsenoside from extracted from patent WO 2008034974 A1, Example 39 in table1. Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 5 mg, 10 mg

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NPPB (5-Nitro-2-(3-phenylpropylamino); Hoechst NRA-0160 144; HOE 144) Cat. No.: HY-101012 Cat. No.: HY-101641

Bioactivity: NPPB is a blocker of the outwardly rectifying chloride Bioactivity: NRA-0160 is a selective dopamine D4 receptor antagonist,

channel ( ORCC). with a Ki value of 0.48 nM and with negligible affinity for

dopamine D2 receptor ( Ki: >10000 nM), D3 receptor (

Ki: 39 nM), rat 5-HT2A receptor ( Ki: 180 nM) and rat Purity: 99.89% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

NS 1738 NS-638 (NSC 213859) Cat. No.: HY-12151 Cat. No.: HY-101428

Bioactivity: NS1738 is a novel positive allosteric modulator of the α7 Bioactivity: NS-638 is a small nonpeptide molecule with Ca2+-channel nAChR, with respect to positive modulation of α7 nAChR (EC blocking properties. K +-stimulated intracellular Ca 50=3.4 μM in oocyte experiments). 2+ -elevation is blocked with an IC50 value of 3.4 μM.

Purity: 99.21% Purity: 98.04% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

NS11394 NS1652 Cat. No.: HY-11048 Cat. No.: HY-100244

Bioactivity: NS11394 is a potent and subtype-selective GABA(A) Bioactivity: NS1652 is a reversible anion conductance inhibitor, blocks receptor-positive modulator; possesses a functional efficacy , with an IC50 of 1.6 μM in human and mouse red selectivity profile of alpha(5) > alpha(3) > alpha(2) blood cells. > alpha(1) at GABA(A) alpha subunit-containing receptors.

Purity: 99.01% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg

NT 13 Nuciferine (TPPT) Cat. No.: HY-P7060 Cat. No.: HY-N0049

Bioactivity: NT 13 (TPPT) is a having the amino acid sequence Bioactivity: Nuciferine is an antagonist at 5-HT2A ( IC50=478 nM), L-threonyl-L-prolyl-L-prolyl-L- amide. NT 13 is a 5-HT ( IC =131 nM), and 5-HT ( IC =1 μM), an inverse partial N-methyl-D-aspartate receptor ( NMDAR) agonist used 2C 50 2B 50 agonist at 5-HT ( IC =150 nM), a partial agonist at D ( in the study of depression, anxiety, and other related 7 50 2

diseases. EC50=64 nM), D5 ( EC50=2.6 μM) and 5-HT6 ( EC50=… Purity: >98% Purity: 99.66% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 5 mg, 10 mg, 25 mg

NXY-059 O-Phospho-L- (Disufenton sodium) Cat. No.: HY-13244 (L-Serine O-phosphate; L-SOP) Cat. No.: HY-15129

Bioactivity: NXY-059 (Cerovive) is the disulfonyl derivative of the Bioactivity: O-Phospho-L-serine is the immediate precursor to L-serine in neuroprotective spin trap phenylbutynitrone(PBN), both the serine synthesis pathway, and an agonist at the group III NXY-059, its parent PBN and their hydrolysis/oxidation product mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); MNT are very powerful scavengers of free radicals. O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2. Purity: >98% Purity: 98.0% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg 100 mg

100 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

OBA-09 Cat. No.: HY-12840 (R79598) Cat. No.: HY-101094

Bioactivity: OBA-09 is a novel multimodal neuroprotectant oxopropanoyloxy Bioactivity: Ocaperidone is an effective antipsychotic agent, acting as a

benzoic acid (a /pyruvate ester); shows robust potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A protective effects in the postischemic brain. agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4

nM for 5-HT 2, a 1-adrenergic receptor, dopamine D 2 Purity: >98% Purity: 98.55% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

Octazamide hydrochloride ( ICI-US 457) Cat. No.: HY-U00101 ((±)-p-Octopamine hydrochlorid) Cat. No.: HY-B0528A

Bioactivity: Octazamide (ICI-US 457) is an analgesic drug. Bioactivity: Octopamine Hydrochloride is an endogenous that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems.

Purity: >98% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

Oiligodendrocyte differentiation promoter 1 Cat. No.: HY-U00394 (LY170053) Cat. No.: HY-14541

Bioactivity: Oiligodendrocyte differentiation promoter 1 belongs to the Bioactivity: Olanzapine(LY170053) is a high affinity for 5-HT2 serotonin oiligodendrocyte differentiation promoter. and D2 dopamine receptor antagonist. IC50 Value: Target: 5-HT Receptor Olanzapine is a that blocks especially the serontonin (5-hydroxytryptamine [5-HT]) 5-HT2A and the dopamine D2 receptors (Ki values are 4 and 11 nM… Purity: >98% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg

Olcegepant hydrochloride (BIBN-4096; BIBN 4096BS) Cat. No.: HY-10095 (BIBN-4096 hydrochloride; BIBN4096BS hydrochloride) Cat. No.: HY-10095A

Bioactivity: Olcegepant is a potent and selective non-peptide antagonist of Bioactivity: Olcegepant hydrochloride is the first potent and selective the calcitonin gene-related peptide 1 (CGRP1) receptor with non-peptide antagonist of the calcitonin gene-related peptide 1

IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP. (CGRP1) receptor with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP.

Purity: 99.32% Purity: 95.46% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 2 mg, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

Ondansetron Hydrochloride (GR38032) Cat. No.: HY-B0002B (GR 38032; SN 307; NSC 665799) Cat. No.: HY-B0002

Bioactivity: Ondansetron(GR38032) is a serotonin 5-HT3 receptor antagonist Bioactivity: Ondansetron is a serotonin 5-HT3 receptor antagonist used used mainly as anantiemetic (to treat nausea and vomiting), mainly as anantiemetic (to treat nausea and vomiting), often often following chemotherapy. following chemotherapy.

Purity: 98.55% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg, 100 mg Size: 10 mg, 50 mg, 100 mg

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Ondansetron hydrochloride dihydrate ONO-8590580 (GR 38032; SN 307; NSC 665799) Cat. No.: HY-B0002A Cat. No.: HY-112788

Bioactivity: Ondansetron is a serotonin 5-HT3 receptor antagonist used Bioactivity: ONO-8590580 is a GABAA α5 negative allosteric modulator. mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. Target: 5- HT3 Receptor IC50 Value: in vitro: 5-HT evoked transient inward currents (EC50 = 3.4 microM; Hill coefficient = 1.8) that were blocked by the 5-HT3… Purity: 99.56% Purity: 99.85% Clinical Data: Launched Clinical Data: No Development Reported Size: 50 mg, 100 mg, 1 g, 5 g Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Opicapone Opioid receptor modulator 1 (BIA 9-1067) Cat. No.: HY-14896 Cat. No.: HY-U00420

Bioactivity: is an available catechol-O-methyltransferase ( Bioactivity: Opioid receptor modulator 1 is a opioid receptor modulator COMT) inhibitor. Opicapone decreases the ATP content of the extracted from patent WO2014072809A2, Compound RA11 in

cells with IC 50 values of 98 μM. EXAMPLE 7.

Purity: 98.80% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 5 mg, 10 mg, 25 mg

Orexin 2 Receptor Agonist Orexin B, human Cat. No.: HY-19320 (Human orexin B) Cat. No.: HY-P1339

Bioactivity: Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) Bioactivity: Orexin B, human is an endogenous agonist at Orexin receptor and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist. with Kis of 420 and 36 nM for OX1 and OX2, respectively.

Purity: 99.93% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg, 50 mg, 100 mg

Orexin B, rat, mouse (Rat orexin B; Orexin B (mouse)) Cat. No.: HY-P1349 Cat. No.: HY-13288

Bioactivity: Orexin B, rat, mouse is an endogenous agonist at Orexin Bioactivity: Org 27569 is a potent CB1 receptor allosteric modulator,

receptor with Kis of 420 and 36 nM for OX1 and OX2, which increases agonist binding, yet blocks agonist-induced respectively. CB1 signaling.

Purity: 95.54% Purity: 98.91% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 500u g, 1 mg, 5 mg 10 mg, 50 mg

Org-10490 Org-26576 Cat. No.: HY-U00077 Cat. No.: HY-101216

Bioactivity: Org-10490 is an antagonist of dopamine D1 receptor and Bioactivity: Org 26576 is a AMPA receptor positive allosteric modulator. dopamine D2 receptor, used for the treatment for psychiatric disease.

Purity: >98% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

102 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

ORL1 antagonist 1 citrate Cat. No.: HY-112263 Cat. No.: HY-B0369A

Bioactivity: ORL1 antagonist 1 is an opioid receptor-like 1 ( ORL1) Bioactivity: Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. antagonist with an IC50 of 61 nM.

Purity: >98% Purity: 99.73% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg

Orphenadrine hydrochloride Cat. No.: HY-B1126 (Octylonium bromide; SP63) Cat. No.: HY-B0499A

Bioactivity: Orphenadrine hydrochloride is an uncompetitive Bioactivity: Otilonium Bromide is an antimuscarinic used as a spasmolytic N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 6.0 agent. ±0.7 μM.

Purity: >98% Purity: 95.07% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Oxcarbazepine Oxethazaine Cat. No.: HY-B0114 () Cat. No.: HY-B0955

Bioactivity: inhibits the binding of [3H]BTX to sodium Bioactivity: Oxethazaine is a topical anesthetic, in preventing channels with IC50 of 160 μM and also inhibits the influx of acid-induced esophageal pain. 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

Purity: 99.82% Purity: 99.86% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 50 mg

Oxidopamine hydrochloride Oxiracetam (6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride) Cat. No.: HY-B1081 (ISF2522) Cat. No.: HY-B1715

Bioactivity: hydrochloride is a neurotoxic synthetic organic Bioactivity: Oxiracetam is a cyclic derivative of γ-aminobutyric acid ( compound, selectively destroys dopaminergic and noradrenergic GABA) which has been commonly used as nootropic drug to treat neurons in the brain. cognitive impairments.

Purity: 95.0% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

Oxybutynin chloride Cat. No.: HY-B0267 Cat. No.: HY-B0267A

Bioactivity: Oxybutynin is an anticholinergic medication used to relieve Bioactivity: Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. urinary and bladder difficulties.

Purity: 98.96% Purity: 98.24% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 100 mg, 500 mg

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Oxyfenamate hydrochloride (Oxyphenamate; P 301) Cat. No.: HY-101754 Cat. No.: HY-B0954

Bioactivity: Oxyfenamate has anti-anxiety actions for use in anxiety Bioactivity: A new tertiary amine, Oxyphencyclimine hydrochloridehas been neuroses. investigated for its effects on the peripheral parasympathetic system. was essentially the most potent in depressing gastric secretion.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 100 mg

p-Hydroxybenzaldehyde P7C3 Cat. No.: HY-Y0313 Cat. No.: HY-15976

Bioactivity: p-Hydroxybenzaldehyde is a one of the major components in Bioactivity: P7C3 is a NAMPT activator. Dendrocalamus asper bamboo shoots, with antagonistic effect on

GABAA receptor of the α 1β 2γ 2S subtype at high concentrations.

Purity: >98% Purity: 98.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 5 g

P7C3-A20 PACAP (1-27), human, ovine, rat Cat. No.: HY-15978 (PACAP 1-27) Cat. No.: HY-P0176

Bioactivity: P7C3-A20 is a derivative of P7C3 with potent neuroprotective Bioactivity: PACAP (1-27), human, ovine, rat, the N-terminal fragment of

activity. PACAP-38, is a potent PACAP receptor antagonist with IC50s of 3, 2, and 5 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2.

Purity: 98.96% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

PACAP (1-38), human, ovine, rat PACAP (6-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38) Cat. No.: HY-P0221 Cat. No.: HY-P0220

Bioactivity: PACAP (1-38), human, ovine, rat is a neuropeptide with 38 Bioactivity: PACAP (6-38), human, ovine, rat is a potent PACAP receptor amino acid residues. PACAP (1-38) binds to PACAP type I antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 … receptor VIP2, respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 500u g, 1 mg, 5 mg

PACAP (6-38), human, ovine, rat TFA PACAP-Related Peptide (PRP), human Cat. No.: HY-P0220A Cat. No.: HY-P1511

Bioactivity: PACAP (6-38), human, ovine, rat is a potent PACAP receptor Bioactivity: PACAP-Related Peptide (PRP), human is a 29 amino-acid region

antagonist with IC50s of 30, 600, and 40 nM for PACAP type I of the PACAP precursor protein.

receptor, PACAP type II receptor VIP1, and PACAP type II

receptor VIP2, respectively. Purity: 98.14% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 500u g, 1 mg, 5 mg

104 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Padsevonil Paeoniflorin (UCB-0942) Cat. No.: HY-109009 (Peoniflorin) Cat. No.: HY-N0293

Bioactivity: Padsevonil is a potent antiepileptic agent. Bioactivity: Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall. Target: Others Paeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's… Purity: 99.88% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 100 mg, 200 mg

Paeonol Cat. No.: HY-N0159 ((+)-RP-59037; IP-456; RP-62955; CI-1043) Cat. No.: HY-101665

Bioactivity: Paeonol is an active extraction from the root of Paeonia Bioactivity: Pagoclone is an active (+)-enantiomer of the racemate RP

suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 59037. Pagoclone is a partial GABA(A) receptor agonist used of 54.6 μM and 42.5 μM, respectively. for the treatment of panic and anxiety disorders.

Purity: 99.98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 250 mg, 1 g 2 mg, 5 mg, 10 mg

Paliperidone Paliroden (9-hydroxyrisperidone) Cat. No.: HY-A0019 (SR 57667) Cat. No.: HY-101580

Bioactivity: (9-hydroxyrisperidone is a dopamine antagonist of Bioactivity: Paliroden is an orally bioactive neurotrophic, non-peptidic the atypical antipsychotic class of . compound that activates synthesis of endogenous neurotrophines, used for treatment of Alzheimer's Disease and Parkinson's.

Purity: 99.09% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 200 mg, 500 mg

Palmitic acid Pancopride (Hexadecoic acid) Cat. No.: HY-N0830 (LAS 30451) Cat. No.: HY-19684

Bioactivity: Palmitic acid is a long-chain saturated fatty acid commonly Bioactivity: Pancopride is a new potent and selective 5-HT3 receptor found in both animals and plants. antagonist.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 g

Pancuronium dibromide Paprotrain Cat. No.: HY-B0429 Cat. No.: HY-101298

Bioactivity: Pancuronium Dibromide is a bis-quaternary steroid that is a Bioactivity: Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2,

competitive . Target: nAChR Pancuronium inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and and a K of 3.36 μM and shows a moderate inhibition activity acts as a skeletal muscle relaxant. Pancuronium dibromide i on DYRK1A with an IC of 5.5 μM. interrupts neuromuscular transmission by competing with… 50 Purity: 98.0% Purity: 97.05% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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Paraxanthine Cat. No.: HY-W016498 (SLV-308; DU-126891) Cat. No.: HY-14958

Bioactivity: , a metabolite, provides protection Bioactivity: Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3 against Dopaminergic cell death via stimulation of Ryanodine receptor agonist and serotonin 5-HT1A receptor agonist; D2 Receptor Channels. (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA = 100%); also binds to D4 (pKi = 7.8),… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: Size: 5 mg, 10 mg, 50 mg, 100 mg

Pardoprunox hydrochloride Pareptide monohydrochloride (SLV-308 hydrochloride; DU-126891 hydrochloride) Cat. No.: HY-14958A Cat. No.: HY-U00271

Bioactivity: Pardoprunox hydrochloride is a novel partial dopamine D2 and Bioactivity: Pareptide monohydrochloride is a melanotropin-inhibiting D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 factor (MIF) metabolically stable analogue. (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.

Purity: 98.89% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Pargolol hydrochloride (Ko 1400 hydrochloride) Cat. No.: HY-101658 Cat. No.: HY-A0091A

Bioactivity: hydrochloride is a β adrenergic receptor Bioactivity: Pargyline is an irreversible non-selective monoamine oxidase antagonist. (MAO) inhibitor drug (IC50 for MAO-A is 11.52 nM and for MAO-B is 8.2 nM) .

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 500 mg

Paroxetine hydrochloride hydrochloride hemihydrate (BRL29060 hydrochloride (BRL29060 hydrochloride; BRL29060A) Cat. No.: HY-B0492 hemihydrate; BRL29060A hemihydrate) Cat. No.: HY-B0492A

Bioactivity: Paroxetine hydrochloride is a potent selective Bioactivity: Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an serotonin-reuptake inhibitor, commonly prescribed as an

antidepressant and has GRK2 inhibitory ability with IC50 of antidepressant and has GRK2 inhibitory ability with IC50 of 14μM. 14μM.

Purity: 99.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg 100 mg, 500 mg

PD 117519 PD173212 (CI947) Cat. No.: HY-100032 Cat. No.: HY-103318

Bioactivity: PD 117519 is an adenosine agonist. Bioactivity: PD173212 is a selective N-type voltage sensitive calcium

channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.

Purity: 98.0% Purity: 95.65% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg

106 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

PDE-9 inhibitor PDE1-IN-2 Cat. No.: HY-50865 Cat. No.: HY-101490

Bioactivity: PDE-9 inhibitor is useful for neurodegenerative diseases. Bioactivity: PDE1-IN-2 is an inhibitor of PDE1 extracted from patent

WO2016/55618 A1, example 31; has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely.

Purity: 99.29% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

PDE10-IN-1 PDE2/PDE10-IN-1 Cat. No.: HY-12813 Cat. No.: HY-U00427

Bioactivity: PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Bioactivity: PDE2/PDE10-IN-1 is a phosphodiesterase 2 ( PDE2) and PDE10 Patent WO 2013192273 A1, for treating CNS and metabolic inhibitor with IC50s of 29 and 480 nM, respectively. disorders.

Purity: 97.82% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg

PE859 PEAQX Cat. No.: HY-12662 (NVP-AAM077) Cat. No.: HY-12294

Bioactivity: PE859 is a potent inhibitor of both tau and Aβ aggregation Bioactivity: PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with IC50 values of 0.66 and 1.2 μM, respectively. with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM). IC50 value: 270 nM(hNMDA A1/A2) [1] Target: NR2A antagonist in vitro: PEAQX has a high binding affinity for NMDA receptors… Purity: 98.01% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) Cat. No.: HY-12294A (1,2,2,6,6-Pentamethylpiperidine) Cat. No.: HY-B1382

Bioactivity: PEAQX(NVP-AAM 077) is a potent and orally active NMDA Bioactivity: Pempidine is a ganglion-blocking drug, introduced as an oral antagonist with a 15-fold preference for human NMDA receptors treatment for hypertension. with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).

Purity: 98.22% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 100 mg

Penfluridol Pentiapine (R-16341) Cat. No.: HY-B1077 (CGS 10746) Cat. No.: HY-100143

Bioactivity: is a highly potent, first generation Bioactivity: Pentiapine is a novel dopamine release inhibitor. antipsychotic.

Purity: 99.84% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg, 100 mg

www.MedChemExpress.com 107

PEPA Peptide YY (PYY), human Cat. No.: HY-12509 Cat. No.: HY-P1514

Bioactivity: PEPA is an allosteric modulator of AMPA receptors; binds to Bioactivity: Peptide YY (PYY) is a gut hormone that regulates appetite and the GluA2o and GluA3o LBDs and can be utilized as an indicator inhibits pancreatic secretion. Peptide YY (PYY) can mediate of AMPA receptor heterogeneity. its effects through the Neuropeptide Y receptors.

Purity: 98.81% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg, 50 mg

Pergolide mesylate ( methanesulfonate; LY127809) Cat. No.: HY-13720A Cat. No.: HY-A0077

Bioactivity: Pergolide Mesylate is an antiparkinsonian agent which Bioactivity: Perphenazine is a drug, inhibits

functions as a dopaminergic agonist. Target: Dopamine Receptor 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine Pergolide mesylate (trade name Permax) is an ergoline-based receptor D2/D3, D2L receptor, and Histamine H1 receptor, dopamine receptor agonist used in some countries for the with K values of 5.6, 10, 0.765/0.13, 3.4, and 8 … treatment of Parkinson's disease. Pergolide mesylate functions… i Purity: 99.31% Purity: 99.90% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 1 g, 5 g

Pexacerfont PF 04531083 (BMS-562086) Cat. No.: HY-12127 Cat. No.: HY-105283

Bioactivity: is a selective corticotropin-releasing factor ( Bioactivity: PF 04531083 is a selective NaV1.8 blocker, and used for the CRF ) receptor antagonist with IC of 6.1±0.6 nM for human 1 50 research of neuropathic/inflammatory pain.

CRF 1 receptor.

Purity: >98% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 250 mg, 500 mg

PF-01247324 PF-04447943 Cat. No.: HY-101383 Cat. No.: HY-15441

Bioactivity: PF-01247324 is a selective and orally bioavailable Nav1.8 Bioactivity: PF-04447943 is a potent inhibitor of human recombinant PDE9A ( IC50=12 nM) with >78-fold selectivity, respectively, over channel blocker with an IC50 of 196 nM for recombinant human other PDE family members ( IC >1000 nM). Na v1.8 channel. 50

Purity: 98.03% Purity: 99.84% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg

PF-04457845 PF-05180999 Cat. No.: HY-14376 Cat. No.: HY-111371

Bioactivity: PF-04457845 is a highly efficacious and selective FAAH Bioactivity: PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with

inhibitor with IC50 values is 7.2±0.63 nM and 7.4±0.62 nM for an IC50 of 1.6 nM. hFAAH and rFAAH, respectively.

Purity: 99.09% Purity: 99.57% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

108 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

PF-05241328 PF-06447475 Cat. No.: HY-103623 Cat. No.: HY-12477

Bioactivity: PF-05241328 is a potent and selective inhibitor of human Bioactivity: PF-06447475 is a highly potent, selective and brain penetrant

Nav1.7 voltage-dependent sodium channels (Nav1.7), with an LRRK2 inhibitor with an IC50 of 3 nM. IC50 of 31 nM.

Purity: >98% Purity: 99.88% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg

PF-06751979 PF-2545920 Cat. No.: HY-112157 Cat. No.: HY-50098

Bioactivity: PF-06751979 is a potent, brain penetrant, β-site amyloid Bioactivity: PF-2545920 is a potent and selective PDE10A inhibitor with precursor protein cleaving enzyme 1 ( BACE1) inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.

an IC 50 of 7.3 nM in BACE1 binding assay. IC50 value: 0.37 nM [1] Target: PDE10A PDE10A subcutaneously administrated at dose of 1 mg/kg elevates striatal cGMP about 3 fold in male CD-1 mice, while PDE10A subcutaneously… Purity: >98% Purity: 99.07% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

PF-3084014 PF-4778574 (Nirogacestat; PF-03084014) Cat. No.: HY-15185 Cat. No.: HY-14451

Bioactivity: PF-3084014 is a reversible, noncompetitive, and selective Bioactivity: PF-4778574 is a positive allosteric modulation of AMPA γ-secretase inhibitor with IC of 6.2 nM. 50 receptor with EC50 of 45 to 919 nM in differenct cells.

Purity: 99.95% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

PF-592379 PF-CBP1 hydrochloride Cat. No.: HY-U00400 Cat. No.: HY-19999A

Bioactivity: PF-592379 is a potent dopamine D3 receptor agonist with Bioactivity: PF-CBP1 hydrochloride is a highly selective inhibitor of the an EC of 21 nM. CREB binding protein bromodomain. Target: CREB in vitro: 50 PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective… Purity: >98% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

PH-002 PH-064 Cat. No.: HY-112798 (BIM-46187) Cat. No.: HY-10499

Bioactivity: PH-002 is an inhibitor of apolipoprotein (apo) E4 Bioactivity: PH-064 is a sodium channel inhibitor extracted from patent FR intramolecular domain interaction in neuronal cells that could 2879460 A1. rescue impairments of mitochondrial motility and neurite outgrowth.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 109

Phe-Met-Arg-Phe amide trifluoroacetate Phe-Met-Arg-Phe, amide Cat. No.: HY-P0249A Cat. No.: HY-P0249

+ Bioactivity: Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K Bioactivity: Phe-Met-Arg-Phe, amide dose dependently (ED 50=23 nM) + current, with ED 50 of 23 nM in the peptidergic caudodorsal activates a K current in the peptidergic caudodorsal neurons. Sequence: Phe-Met-Arg-Phe-NH2. neurons. Sequence: Phe-Met-Arg-Phe-NH2.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 25 mg

Phenelzine sulfate Cat. No.: HY-B1018 Cat. No.: HY-B1018A

Bioactivity: Phenelzine is a non-selective and irreversible monoamine Bioactivity: Phenelzine sulfate is a non-selective and irreversible oxidase inhibitor (MAOI), used as an antidepressant and monoamine oxidase inhibitor (MAOI), used as an antidepressant anxiolytic. and anxiolytic.

Purity: >98% Purity: 98.70% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg, 1 g, 2 g, 5 g

Phenylbiguanide (N-; PBG; 1-Phenylbiguanide) Cat. No.: HY-101331 Cat. No.: HY-14840

Bioactivity: Phenylbiguanide is a 5-HT3 receptor selective agonist with Bioactivity: Phenylpiracetam(Phenotropyl; Phenotropil) is a phenylated an EC of 3.0±0.1 μM. derivative of the nootropic drug . It is used as a 50 stimulant nootropic drug that can be up to 30-60 times more potent than piracetam.

Purity: 98.0% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Phenytoin Phenytoin sodium (5,5-Diphenylhydantoin) Cat. No.: HY-B0448 (5,5-Diphenylhydantoin sodium salt) Cat. No.: HY-B0448A

Bioactivity: Phenytoin is an inactive voltage-gated sodium channel Bioactivity: Phenytoin sodium is an inactive voltage-gated sodium channel stabilizer. stabilizer.

Purity: 99.91% Purity: 99.91% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 1 g, 5 g

Philanthotoxin 74 dihydrochloride Physalaemin (PhTx 74 dihydrochloride) Cat. No.: HY-104020A Cat. No.: HY-P0255

Bioactivity: 74 dihydrochloride (PhTx 74) is an AMPAR Bioactivity: Physalaemin, a non-mammalian tachykinin, binds selectively to

antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 neurokinin-1 ( NK1) receptor with high affinity. Sequence: nM, respectively. GLP-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2.

Purity: 98.89% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg, 25 mg

110 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Picrotoxin Pifithrin-μ (Cocculin) Cat. No.: HY-101391 (PFTμ; 2-Phenylethynesulfonamide) Cat. No.: HY-10940

Bioactivity: is a noncompetitive antagonist of GABAA receptor. Bioactivity: Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.

Purity: 98.0% Purity: 98.31% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 10 mg

Pilocarpine Hydrochloride Pilocarpine nitrate Cat. No.: HY-B0726 Cat. No.: HY-B1006

Bioactivity: Pilocarpine Hydrochloride is a selective M3-type muscarinic Bioactivity: Pilocarpine nitrate is a selective M3-type muscarinic acetylcholine receptor ( M3 muscarinic receptor) agonist. acetylcholine receptor ( M3 muscarinic receptor) agonist.

Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 500 mg Size: 100 mg

Pimavanserin tartrate (ACP-103) Cat. No.: HY-14557 (ACP-103 tartrate) Cat. No.: HY-14557A

Bioactivity: Pimavanserin is a selective inverse agonist of the 5-HT2A Bioactivity: Pimavanserin tartrate (ACP-103) is a potent 5-HT 2A receptor

receptor with pIC50 and pKd of 8.73 and 9.3, respectively. inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.

Purity: 99.73% Purity: 99.50% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Pimethixene (Pimetixene) Cat. No.: HY-B1101 (R6238) Cat. No.: HY-12987

Bioactivity: is an antihistamine and anticholinergic agent, Bioactivity: Pimozide is a dopamine receptor antagonist, with Kis of that is often used to treat hyperactivity, anxiety, sleep 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 disorders, and allergy. receptors, respectively, and also has affinity at

α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhib… Purity: >98% Purity: 98.01% Clinical Data: Launched Clinical Data: Launched Size: 10 mg Size: 10mM x 1mL in DMSO, 50 mg

Pindolol Cat. No.: HY-B0982 (PK-8165) Cat. No.: HY-100140

Bioactivity: is a nonselective β-blocker with partial Bioactivity: Pipequaline (PK 8165) is a non-selective GABAA receptor beta-adrenergic receptor agonist activity, also functions as a partial agonist with anxiolytic activity. 5-HT1A receptor weak partial agonist / antagonist (Ki=33nM).

Purity: 99.84% Purity: 98.61% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 111

Piperacetazine -MO-1 Cat. No.: HY-B1152 Cat. No.: HY-19845A

Bioactivity: is an antipsychotic prodrug, used Bioactivity: Piperidine-MO-1 is a modulator of dopamine receptor forschizophrenia. extracted from patent WO/2005/121087A1, compound example 2;

exhibits an ED50 of 68 μmol/kg on increase of DOPAC in the rat striatum.

Purity: 99.86% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg

Piperidinylaminomethyl Trifluoromethyl Cyclic Ether Compound 1 Cat. No.: HY-U00382 Cat. No.: HY-B0962A Bioactivity: Piperidinylaminomethyl Trifluoromethyl Cyclic Ether Compound 1 Bioactivity: Piperidolate is an antimuscarinic, inhibits intestinal cramp has the potential function in central nervous system induced by acetylcholine (rats and dogs). disorders, respiratory, inflammatory diseases and gastrointestinal disorders.

Purity: >98% Purity: 99.09% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg

Piperidolate hydrochloride Piperylone Cat. No.: HY-B0962 (PR66) Cat. No.: HY-U00195

Bioactivity: Piperidolate hydrochloride is an antimuscarinic, inhibits Bioactivity: Piperylone can be used as an antispasmodic. intestinal cramp induced by acetylcholine (rats and dogs).

Purity: 99.94% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 200 mg

Piracetam dihydrochloride Cat. No.: HY-B0585 (LS519) Cat. No.: HY-17037

Bioactivity: Piracetam is a cyclic derivative of the neurotransmitter Bioactivity: Pirenzepine dihydrochloride (LS519) is a selective M1 gamma-aminobutyric acid (GABA), used in treatment of a wide muscarinic receptor antagonist. range of cognitive disorders.

Purity: 99.0% Purity: 99.60% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 100 mg, 500 mg

Piribedil hydrochloride Cat. No.: HY-12707 (Lucaine hydrochloride) Cat. No.: HY-U00109

Bioactivity: is a dopamine D2 receptor ( D2R) agonist Bioactivity: Piridocaine hydrochloride (Lucaine hydrochloride) is a which also displays antagonist property at hα -adrenoceptor piperidyl propanol ester of orthoaminobenzoic acid used as a 1A local anesthetic drug. ( hα1A-AR).

Purity: 99.90% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

112 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Pitofenone hydrochloride Cat. No.: HY-110389 (Tiprolisant) Cat. No.: HY-12199

Bioactivity: Pitofenone hydrochloride, a spasmolytic compound, inhibits the Bioactivity: Pitolisant is a potent and selective nonimidazole inverse acetylcholinesterase ( AChE) activity from bovine erythrocytes agonist at the recombinant human histamine H3 receptor (

and from electric eel with Kis of 36 and 45 μM, respectively. Ki=0.16 nM).

Purity: 99.88% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

Pitolisant hydrochloride Pitolisant oxalate (Ciproxidine; BF 2649) Cat. No.: HY-12199B (Tiprolisant oxalate) Cat. No.: HY-12199A

Bioactivity: Pitolisant hydrochloride is a potent and selective Bioactivity: Pitolisant oxalate is a potent and selective nonimidazole nonimidazole inverse agonist at the recombinant human inverse agonist at the recombinant human histamine H3

histamine H3 receptor ( Ki=0.16 nM). receptor ( Ki=0.16 nM).

Purity: 99.22% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg

Pizotifen malate (Pizotyline) Cat. No.: HY-B0115 (Pizotyline malate) Cat. No.: HY-B0115A

Bioactivity: Pizotifen is a potent 5-HT2 receptor antagonist, with a high Bioactivity: Pizotifen malate is a potent 5-HT2 receptor antagonist, with

affinity for 5-HT1C binding site. a high affinity for 5-HT1C binding site.

Purity: 99.65% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 200 mg, 500 mg 100 mg, 200 mg, 500 mg

PKG Substrate PNU-120596 Cat. No.: HY-P1561 (NSC 216666) Cat. No.: HY-12152

Bioactivity: PKG Substrate is a selective substrate for cGMP-dependent Bioactivity: PNU-120596 (NSC 216666 ) is a potent and selective positive protein kinase ( PKG). allosteric α7 nAChR modulator with an EC50 of 0.2 μM.

Purity: >98% Purity: 98.15% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

PNU-282987 Podocarpic acid Cat. No.: HY-12560A Cat. No.: HY-N2318

Bioactivity: PNU-282987 is a selective α7 nicotinic acetylcholine Bioactivity: Podocarpic acid is a natural product, which has the best receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for all-round positive effect and acts as a novel TRPA1 α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). IC50 value: 26 nM(Ki) activator. [1] Target: α7 nAChR agonist in vitro: Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in… Purity: 99.70% Purity: 99.37% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg

www.MedChemExpress.com 113

Pralidoxime chloride Pramipexole (2-PAM chloride) Cat. No.: HY-B1200 Cat. No.: HY-B0410

Bioactivity: chloride is a useful agent in the treatment of Bioactivity: Pramipexole is a dopamine agonist of the non-ergoline class organophosphate poisoning. Pralidoxime binds to indicated for treating Parkinson's disease (PD) and restless organophosphate-inactivated acetylcholinesterase, used to legs syndrome (RLS). combat poisoning by or acetylcholinesterase inhibitors (nerve agents) in conjunction with atropine and… Purity: 99.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 50 mg, 100 mg 100 mg

Pramipexole dihydrochloride Cat. No.: HY-17355 Cat. No.: HY-17455

Bioactivity: Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor Bioactivity: Pramiracetam is a nootropic drug derived from piracetam, and agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, is more potent. Pramiracetam reportedly improved cognitive D3, D4 receptor, respectively. IC50 Value: 3.9 nM(D2S); 2.2 deficits associated with traumatic brain injuries. nM(D2L); 0.5 nM(D3); 5.1 nM(D4) Target: Dopamine Receptor Pramipexole dihydrochloride is a dopamine receptor agonist… Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 50 mg, 200 mg

Pramocaine hydrochloride PRE-084 hydrochloride (Pramoxine hydrochloride) Cat. No.: HY-B1319 Cat. No.: HY-18100A

Bioactivity: Pramocaine hydrochloride is a topical anesthetic, and used as Bioactivity: PRE-084 hydrochloride is a high affinity, selective σ1 an antipruritic. agonist, has an IC50 of 44 nM in the assay.

Purity: 99.83% Purity: 99.79% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 10 mg, 50 mg, 100 mg

Pregnenolone monosulfate (Arthenolone; 3β-Hydroxy-5-pregnen-20-one) Cat. No.: HY-B0151 (Pregn-5-en-20-on-3β-yl sulfuric acid) Cat. No.: HY-B1739

Bioactivity: Pregnenolone acts as a signaling-specific inhibitor of Bioactivity: Pregnenolone monosulfate acts as a signaling-specific cannabinoid CB1 receptor, reduces several effects of inhibitor of cannabinoid CB1 receptor, reduces several effects (THC). of tetrahydrocannabinol (THC).

Purity: 98.0% Purity: >98% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 g, 5 g

Preladenant Prenyl-IN-1 (SCH-420814) Cat. No.: HY-10889 Cat. No.: HY-U00327

Bioactivity: Preladenant is a potent and competitive antagonist of the Bioactivity: Prenyl-IN-1 is a protein prenylation inhibitor, especially a

human adenosine A2A receptor with a Ki of 1.1 nM and has over geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) 1000-fold selectivity over other adenosine receptors. inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease. Purity: 99.08% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

114 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Pressinoic Acid Cat. No.: HY-P1487 (ACR16; ASP2314; FR310826) Cat. No.: HY-10684

Bioactivity: Pressinoic Acid is a synthetic hexapeptide with potent Bioactivity: Pridopidine, a dopamine ( DA) stabilizer, acts as a low corticotrophin-releasing activity. Pressinoic Acid is also an affinity dopamine D2 receptor ( D2R) antagonist. inhibitor; it induces maternal behavior. Pridopidine exerts high affinity towards sigma 1 receptor

( S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R. Purity: >98% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Primidone Cat. No.: HY-B0339 Cat. No.: HY-B0546

Bioactivity: is an anticonvulsant of the pyrimidinedione class. Bioactivity: Procaine is a local anesthetic drug of the amino ester group, which acts through multiple targets. Target: Others Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the… Purity: 99.74% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 g, 5 g 100 mg

Procaine hydrochloride Procion Blue HB Cat. No.: HY-B0546A (Reactive Blue 2) Cat. No.: HY-D0965

Bioactivity: Procaine Hydrochloride is a local anesthetic drug of the amino Bioactivity: Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. ester group.

Purity: 99.95% Purity: 95.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 g, 5 g Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Proctolin hydrochloride Cat. No.: HY-P0275 ((±)-Procyclidine hydrochlorid) Cat. No.: HY-B1487

Bioactivity: Proctolin is an endogenous pentapeptide that acts as an Bioactivity: Procyclidine hydrochloride is a potent anti-cholinergic agent, excitatory neuromodulator. Sequence: Arg-Tyr-Leu-Pro-Thr. and is also known to have NMDA antagonist properties.

Purity: >98% Purity: 99.35% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 100 mg

Progabide Releasing Peptide (1-31), human (SL 76002) Cat. No.: HY-A0173 Cat. No.: HY-P1520

Bioactivity: is a gamma-aminobutyric acid receptor ( GABA) Bioactivity: Prolactin Releasing Peptide (1-31), human is a high affinity agonist. GPR10 ligand that cause the release of the prolactin. Human and rat Prolactin Releasing Peptide (1-31) binds to GPR10 with

Kis of 1.03 and 0.33 nM, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 500u g, 1 mg, 5 mg

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Prolactin Releasing Peptide (12-31), human hydrochloride Cat. No.: HY-P1530 Cat. No.: HY-B1225

Bioactivity: Prolactin Releasing Peptide (12-31), human is a fragment of Bioactivity: Promazine (hydrochloride) is a D2 dopamine receptor the prolactin releasing peptide (PrRP). Prolactin Releasing antagonist, belongs to the phenothiazine class of Peptide (1-31), human is a high affinity GPR10 ligand that , used to treat schizophrenia. cause the release of the prolactin.

Purity: >98% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: Launched Size: 500u g, 1 mg Size: 10mM x 1mL in Water, 100 mg

Promethazine hydrochloride Cat. No.: HY-B0781 Cat. No.: HY-B1188

Bioactivity: Hcl(NSC-231688) is the first-generation Bioactivity: Propantheline bromide is an antimuscarinic agent, used for the antihistamine; strong antagonist of the H1 receptor and treatment of hyperhidrosis, cramps or spasms of the stomach, moderate mACh receptor antagonist, moderate affinity for intestines or bladder, and enuresis. 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

Purity: 99.82% Purity: 95.0% Clinical Data: Launched Clinical Data: Launched Size: 1 g, 5 g Size: 10mM x 1mL in DMSO, 100 mg

Proparacaine Hydrochloride hydrochloride ( Hydrochloride) Cat. No.: HY-66012 Cat. No.: HY-B1243

Bioactivity: Proparacaine Hydrochloride is a voltage-gated sodium channels Bioactivity: Propoxycaine hydrochloride is the hydrochloride salt form of antagonist with ED50 of 3.4 mM. Propoxycaine, a para-aminobenzoic acid ester with local anesthetic activity. Target: sodium channel Propoxycaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and… Purity: 99.56% Purity: 99.98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg

Propranolol hydrochloride Protocatechuic acid Cat. No.: HY-B0573 (3,4-Dihydroxybenzoic acid) Cat. No.: HY-N0294

Bioactivity: hydrochloride is a nonselective β-adrenergic Bioactivity: Protocatechuic acid is a phenolic compound which exhibits

receptor ( βAR) antagonist with an IC50 of 12 nM. neuroprotective effect.

Purity: 99.92% Purity: 99.80% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg, 1 g 200 mg, 1 g

Protriptyline hydrochloride Cat. No.: HY-B0949 Cat. No.: HY-14151

Bioactivity: is a tricyclic antidepressant (TCA), Bioactivity: Prucalopride (R093877) is a drug acting as a selective, high specifically a secondary amine, for the treatment of affinity 5-HT4 receptor agonist(pKi=8.6/8.1 for 5-HT4a/4b); depression and ADHD. Unique among the TCAs, protriptyline >150-fold higher affinity for 5-HT4 receptors than for tends to be energizing instead of sedating, used for other receptors. IC50 value: 8.6/8.1 for 5-HT4a/4b(pKi) to achieve a wakefulness-promoting effect. Target: 5-HT4 receptor Prucalopride is a novel enterokinetic… Purity: 99.91% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 10 mg, 50 mg, 100 mg

116 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

PSB-12062 Purmorphamine (N-(p-Methylphenylsulfonyl)phenoxazine) Cat. No.: HY-101910 Cat. No.: HY-15108

Bioactivity: PSB-12062 is a potent and selective P2X4 antagonist with an Bioactivity: Purmorphamine is an activator of Smoothened, and blocks

IC50 of 1.38 μM for human P2X4. BODIPY-cyclopamine binding to Smo with IC50 of appr 1.5 μM and

also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purity: 98.45% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

Pyridazinediones-derivative-1 bromide Cat. No.: HY-U00127 Cat. No.: HY-B0207A

Bioactivity: Pyridazinediones-derivative-1 has potential in treating Bioactivity: Pyridostigmine is a parasympathomimetic and a reversible

neurodegenerative disorders. It shows an ED50 of 2.1 μM for . Target: AChE Pyridostigmine is a inhibiting glutamate-induced contractions of isolated parasympathomimetic and a reversible cholinesterase inhibitor. guineapig ileum. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood–brain barrier, except… Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in Water, 1 g, 5 g

Pyridoxal phosphate Pyridoxine (Pyridoxal 5′-phosphate; Pyridoxyl phosphate) Cat. No.: HY-B1744 (Pyridoxol; Vitamin B6) Cat. No.: HY-B1328

Bioactivity: Pyridoxal phosphate is the active form of vitamin B6, acts as Bioactivity: Pyridoxine is a pyridine derivative. Pyridoxine exerts an inhibitor of reverse transcriptases, and is used for the antioxidant effects in cell model of Alzheimer's disease via treatment of tardive . the Nrf-2/HO-1 pathway.

Purity: 98.22% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 500 mg 100 mg, 1 g

Pyrithioxin Pyrithioxin dihydrochloride ( dihydrochloride; (Pyritinol; Pyridoxine disulfide; Vitamin B6 disulfide) Cat. No.: HY-B0910 Pyridoxine disulfide dihydrochloride; …) Cat. No.: HY-B0910A

Bioactivity: Pyrithioxin is a neurodynamic compound, combined with a short Bioactivity: Pyrithioxin dihydrochloride is a neurodynamic compound, period of hyperventilation (HV) was applied in cerebral combined with a short period of hyperventilation (HV) was infarct patients with Hemiplegia. applied in cerebral infarct patients with Hemiplegia.

Purity: >98% Purity: 99.0% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in Water, 100 mg

Pyrrolifene PZM21 Cat. No.: HY-U00081 Cat. No.: HY-101386

Bioactivity: Pyrrolifene is an analgesic with anti-inflammatory effect. Bioactivity: PZM21 is a potent and selective μ opioid receptor agonist

with an EC50 of 1.8 nM.

Purity: >98% Purity: 99.45% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

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QNZ QNZ46 (EVP4593) Cat. No.: HY-13812 Cat. No.: HY-15703

Bioactivity: QNZ shows strong inhibitory effects on NF-κB transcriptional Bioactivity: QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM activation and TNF-α production with IC50s of 11 and 7 nM, respectively. EVP4593 is a neuroprotective inhibitor of SOC for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). IC50 channel. value: 3 μM (for NR2D), 6 μM (for NR2C), 229 μM (for NR2D NR2A) Target: NR2D, NR2C, NR2A in vitro: QNZ46 is a… Purity: 98.46% Purity: 98.89% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

Quetiapine fumarate Cat. No.: HY-14544 Cat. No.: HY-B0031

Bioactivity: Quetiapine(Ketipinor) is an atypical antipsychotic used in the Bioactivity: Quetiapine fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression. depression, bipolar I depression.

Purity: 99.83% Purity: 99.54 Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 g, 5 g

Quetiapine sulfoxide dihydrochloride (Quetiapine sulfoxide Quinagolide hydrochloride dihydrochloride; Quetiapine S-oxide dihydrochloride) Cat. No.: HY-G0014A (CV205-502 hydrochloride) Cat. No.: HY-13736A

Bioactivity: Quetiapine Sulfoxide is a metabolite of Quetiapine. Quetiapine Bioactivity: Quinagolide hydrochloride is a selective dopamine D2 receptor is an atypical antipsychotic approved for the treatment of agonist, also is a prolactin inhibitor. Target: dopamine D2 schizophrenia, bipolar disorder, and along with an receptor, prolactin Quinagolide is a selective, D2 receptor antidepressant to treat major depressive disorder. agonist (or prolactin-release inhibitor) that is used for the treatment of elevated levels of prolactin. Quinagolide is… Purity: 98.0% Purity: 99.78% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Quinolinic acid Quinpirole Hydrochloride Cat. No.: HY-100807 ((-)-LY 171555) Cat. No.: HY-B1752A

Bioactivity: is an endogenous N-methyl-D-aspartate receptor Bioactivity: Quinpirole (Hydrochloride) is a high-affinity agonist agonist synthesized from L-tryptophan via the kynurenine dopamine D2/D3 receptor. pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 g

R121919 rac- Hydrochloride (NBI30775) Cat. No.: HY-14127 Cat. No.: HY-15394

Bioactivity: R121919 is a potent small-molecule CRF1 receptor antagonist Bioactivity: rac-Rotigotine Hcl is a high potency and selectivity agonist

with a Ki of 2 to 5 nM for the CRF1 receptor and over for D-2 receptor with Ki of 0.69 nM. 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.

Purity: 99.46% Purity: 97.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg 10 mg, 50 mg, 100 mg

118 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Racecadotril hydrochloride (Acetorphan) Cat. No.: HY-17399 (GW-353162A; BW-306U) Cat. No.: HY-17590

Bioactivity: (acetorphan), a potent inhibitor Bioactivity: Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of (IC50= 4.5 uM), protects endogenous from ; selective for inhibiting the reuptake of degradation. IC50 value: 4.5 uM Target: Enkephalinase norepinephrine over dopamine; DAT (dopamine transporter) and Racecadotril is a peripherally acting NET(norepinephrine transporter) transporters inhibitor, and with an IC50 of 4.5 uM. Unlike other medications used to treat… nAChR family modulator. Purity: 98.0% Purity: 99.47% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 200 mg, 1 g 5 mg, 10 mg

Ramelteon metabolite M-II (TAK-375) Cat. No.: HY-A0014 Cat. No.: HY-103005

Bioactivity: Ramelteon is a highly potent and selective melatonin Bioactivity: Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC s of 208 pM, 1470 pM for human melatonin receptor agonist with Ki values of 14 and 112 pM for human 50

melatonin1 and melatonin2. receptors (MT 1 or MT 2). Ramelteon is a selective melatonin agonist. Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg, 500 mg

Ramosetron Hydrochloride (YM060) Cat. No.: HY-B0595 (Org 9487) Cat. No.: HY-16423

Bioactivity: Hydrochloride(YM060 Hydrochloride) is a serotonin Bioactivity: Rapacuronium bromide is an allosteric modulator of muscarinic 5-HT3 receptor antagonist for the treatment of nausea and acetylcholine receptor ( mAChR). vomiting.

Purity: 99.85% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500 mg, 250 mg 10 mg, 50 mg

Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate; (GLYX-13; Thr-Pro-Pro-Thr-NH2) Cat. No.: HY-16728 Thr-Pro-Pro-Thr-NH2 Trifluoroacetate) Cat. No.: HY-16728B

Bioactivity: Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor Bioactivity: Rapastinel Trifluoroacetate is an NMDA receptor modulator (NMDAR) modulator that has characteristics of a glycine site with glycine-site partial agonist properties and currently in partial agonist. a phase II clinical development program as an adjunctive therapy for major depressive disorder.

Purity: 99.49% Purity: 98.0% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg

Rasagiline mesylate (AGN1135; TVP1012) Cat. No.: HY-14605A (AGN1135; TVP1012) Cat. No.: HY-14605

Bioactivity: Rasagiline(AGN1135;TVP1012) is a new MAO-B inhibitor for the Bioactivity: Rasagiline Mesylate is a new MAO-B inhibitor for the treatment treatment of idiopathic Parkinson's disease. Target: Monoamine of idiopathic Parkinson's disease. Target: Monoamine Oxidase Oxidase (MAO)-B Rasagiline (N-propargyl-1-(R)-aminoindan) is a (MAO)-B Rasagiline (N-propargyl-1-(R)-aminoindan) is a novel, novel, highly potent irreversible monoamine oxidase (MAO)-B highly potent irreversible monoamine oxidase (MAO)-B inhibitor, anti-Parkinsonian drug. Rasagiline is effective as… inhibitor, anti-Parkinsonian drug. Rasagiline is effective as… Purity: >98% Purity: 97.56% Clinical Data: Launched Clinical Data: Launched Size: 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg

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Rat CGRP-(8-37) Rat orexin A Cat. No.: HY-P0209 Cat. No.: HY-106224

Bioactivity: Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a Bioactivity: Rat orexin A is an important neuropeptide involved in the highly selective CGRP receptor antagonist. Sequence: Val-Thr regulation of feeding, , energy consuming, and reward -His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-A seeking in the body. sp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2.

Purity: 98.29% Purity: 96.07% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg

Rauwolscine hydrochloride (α- hydrochloride; Real Thiol Corynanthidine hydrochloride; Isoyohimbine hydrochloride) Cat. No.: HY-12710A Cat. No.: HY-108715

Bioactivity: hydrochloride is a potent and specific α2 Bioactivity: Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione adrenergic receptor antagonist with a Ki of 12 nM. dynamics in living cells.

Purity: 99.16% Purity: 99.76% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 50 mg, 100 mg

Reboxetine mesylate benzenesulfonate (FCE20124 mesylate; PNU155950E mesylate) Cat. No.: HY-14560C (CN-7056 benzenesulfonate) Cat. No.: HY-14867A

Bioactivity: Mesylate is a norepinephrine reuptake inhibitor use Bioactivity: Remimazolam benzenesulfonate is a GABA agonist. in the treatment of unipolar depression.

Purity: 99.87% Purity: 97.78% Clinical Data: Phase 4 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

Reserpine hydrochloride Cat. No.: HY-N0480 Cat. No.: HY-N0480A

Bioactivity: Reserpine is an inhibitor of the vesicular monoamine Bioactivity: Reserpine hydrochloride is an inhibitor of the vesicular transporter 2 ( VMAT2). 2 ( VMAT2).

Purity: 99.83% Purity: 99.84% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

Retosiban RF9 (GSK 221149; GSK 221149A) Cat. No.: HY-14778 Cat. No.: HY-107382

Bioactivity: (GSK221149A) is a potent and selective oxytocin Bioactivity: RF9 is a potent and selective Neuropeptide FF receptor

antagonist with a Ki of 0.65 nM. antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively.

Purity: >98% Purity: 98.24% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg

120 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

RG3039 RG7090 (PF-06687859) Cat. No.: HY-102020 (; CTEP Derivative) Cat. No.: HY-15446

Bioactivity: RG3039 (PF-06687859) is an orally bioavailable and Bioactivity: RG7090 (Basimglurant, RO4917523) is a potent, selective and

brain-penetrant DcpS inhibitor with an IC50 of 0.069 nM. orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.

Purity: 98.36% Purity: 96.82% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

RG7800 hydrochloride Rilapladib (RO6885247 hydrochloride) Cat. No.: HY-101792A (SB 659032) Cat. No.: HY-102004

Bioactivity: RG7800 hydrochloride is an orally active SMN2 splicing Bioactivity: Rilapladib is a selective Lipoprotein-Associated Phospholipase

modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 A2 ( Lp-PLA2) inhibitor with an IC50 of 230 pM. splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.

Purity: 99.70% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

Riluzole hydrochloride (PK 26124) Cat. No.: HY-B0211 (PK 26124 hydrochloride) Cat. No.: HY-B0211A

Bioactivity: Riluzole is an anticonvulsant drug and belongs to the family Bioactivity: Riluzole hydrochloride is an anticonvulsant drug and belongs of use-dependent Na+ channel blocker which can also inhibit to the family of use-dependent Na+ channel blocker which can

GABA uptake with an IC50 of 43 μM. also inhibit GABA uptake with an IC50 of 43 μM.

Purity: 99.83% Purity: 99.94% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 50 mg, 100 mg, 500 mg, 1 g 50 mg, 100 mg, 500 mg

Rislenemdaz Rispenzepine (MK-0657; CERC-301) Cat. No.: HY-106441A Cat. No.: HY-U00030

Bioactivity: Rislenemdaz (CERC-301) is an orally bioavailable and selective Bioactivity: Rispenzepine is a novel antimuscarinic compound with a

N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) preferential action at M1, and M3 receptor subtypes. antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM, respectively.

Purity: 98.01% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg, 50 mg

Risperidone hydrochloride (R 64 766) Cat. No.: HY-11018 (R 64 766 hydrochloride) Cat. No.: HY-11018A

Bioactivity: Risperidone is a serotonin 5-HT2 receptor blocker, Bioactivity: Risperidone hydrochloride is a serotonin 5-HT2 receptor

P-Glycoprotein inhibitor and potent dopamine D2 receptor blocker and a potent dopamine D2 receptor antagonist,

antagonist, with Kis of 4.8, 5.9 nM for 5-HT 2A and dopamine with Kis of 0.16, 1.4 nM for 5-HT 2 and D 2 receptor,

D 2 receptor, respectively. respectively. Purity: 99.16% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg, 100 mg Size: 10 mg, 50 mg, 100 mg

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Risperidone mesylate (R 64 766 mesylate) Cat. No.: HY-11018B (S-Rivastigmine) Cat. No.: HY-17368

Bioactivity: Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2 Bioactivity: Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), receptor blocker(Ki= 0.16 nM) and a potent dopamine D2 inhibits both butyrylcholinesterase and acetylcholinesterase. receptor antagonist(Ki= 1.4 nM).

Purity: >98% Purity: 99.39% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg

Rivastigmine tartrate RJR-2403 (ENA 713; SDZ-ENA 713) Cat. No.: HY-11017 (; Metanicotine) Cat. No.: HY-13225A

Bioactivity: Rivastigmine tartrate, an cholinesterase inhibitor(IC50= 5.5 Bioactivity: RJR-2403(Metanicotine; Rivanicline) is a neuronal nicotinic uM), inhibits both butyrylcholinesterase and receptor agonist, showing high selectivity for the α4β2 acetylcholinesterase subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).

Purity: 98.53% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 50 mg, 100 mg, 200 mg

RJR-2403 hemioxalate RJR-2403 oxalate (Rivanicline hemioxalate; Metanicotine hemioxalate) Cat. No.: HY-13225B ((E)-Metanicotine oxalate; Rivanicline oxalate) Cat. No.: HY-13225

Bioactivity: RJR-2403 hemioxalate(Metanicotine; Rivanicline) is a neuronal Bioactivity: RJR-2403 oxalate(Metanicotine; Rivanicline) is a neuronal nicotinic receptor agonist, showing high selectivity for the nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM). receptors(Ki= 36000 nM). IC50 value: 26 nM [1] Target: α4β2 nAChR in vitro: At concentrations up to 1 mM, RJR-2403 does… Purity: 95.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg, 50 mg

RN-1734 Ro 22-3245 Cat. No.: HY-19975 Cat. No.: HY-U00078

Bioactivity: RN-1734 is selective antagonist of the TRPV4 channel, Bioactivity: Ro 22-3245 is an anxiolytic used in the treatment of anxiety. completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM). Purity: 98.36% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Ro 25-6981 Ro 25-6981 Maleate Cat. No.: HY-13993 Cat. No.: HY-13993A

Bioactivity: Ro 25-6981 is a potent and selective activity-dependent Bioactivity: Ro 25-6981 Maleate is a potent and selective blocker of NMDA receptors containing the NR2B subunit. IC50 activity-dependent blocker of NMDA receptors containing the values are 0.009 and 52 μM for cloned receptor subunit NR2B subunit. IC50 values are 0.009 and 52 μM for cloned combinations NR1C/NR2B and NR1C/NR2A respectively. receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. IC50 value: 9 nM [1] Target: NMDA receptor… Purity: >98% Purity: 98.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

122 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Ro 31-8220 Ro 31-8220 mesylate (Ro 31-8220 methanesulfonate; (Bisindolylmaleimide IX) Cat. No.: HY-13866A Bisindolylmaleimide IX mesylate) Cat. No.: HY-13866

Bioactivity: Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, Bioactivity: Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, rat brain PKC, respectively. Ro 31-8220 also significantly PKCε and rat brain PKC, respectively. Ro 31-8220 also

inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β ( IC50s, 3, 8, … significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3… Purity: >98% Purity: 99.28% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Ro 41-1049 hydrochloride Ro 41-3290 Cat. No.: HY-100027A Cat. No.: HY-U00215

Bioactivity: Ro 41-1049 hydrochloride is a selective, reversible, Bioactivity: Ro 41-3290 is the desethylated derivative of Ro 41-3696, which orally-active MAO-A inhibitor. is a partial agonist at the benzodiazepine receptor. Ro 41-3290 is an investigational hypnotic.

Purity: 99.79% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

RO 4938581 Ro 61-8048 Cat. No.: HY-107489 Cat. No.: HY-12347

Bioactivity: RO 4938581 is a potent and selective GABAA α5 inverse Bioactivity: Ro 61-8048 is a potent and selective inhibitors of kynurenine hydroxylase with IC50 of 37 nM. agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a

lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a ( Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research… Purity: >98% Purity: 99.41% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

RO4929097 RO5028442 (RG-4733) Cat. No.: HY-11102 Cat. No.: HY-12981

Bioactivity: RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, Bioactivity: RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a ( V1a) receptor antagonist with K s of 1 nM ( inhibiting cellular processing of Aβ40 and Notch with EC 50 i of 14 nM and 5 nM, respectively. hV1a) and 39 nM ( mV1a).

Purity: 98.02% Purity: 99.49% Clinical Data: Phase 2 Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Rocuronium Cat. No.: HY-17033 Cat. No.: HY-17440

Bioactivity: Rocuronium is an non-depolarizing neuromuscular Bioactivity: Rocuronium Bromide is an aminosteroid non-depolarizing blocker or muscle relaxant used in modern anaesthesia. IC50 neuromuscular blocker or muscle relaxant used in modern value: Target: anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation. IC50 Value: in vitro: Rocuronium reduced the… Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

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Rolipram hydrochloride ((R,S)-Rolipram; SB 95952; ZK 62711) Cat. No.: HY-16900 (SKF 101468 hydrochloride) Cat. No.: HY-B0623A

Bioactivity: Rolipram is a selective phosphodiesterases PDE4 inhibitor Bioactivity: Ropinirole hydrochloride(SKF101468 hydrochloride) a selective dopamine D2 receptor inhibitor with IC50 of 29 nM. with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Purity: 99.56% Purity: 99.93% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 50 mg, 100 mg, 200 mg

Ropivacaine hydrochloride hydrochloride monohydrate Cat. No.: HY-B0563B Cat. No.: HY-B0563A

Bioactivity: Ropivacaine hydrochloride is an inhibitor of K2P (two-pore Bioactivity: Ropivacaine HCl is an anaesthetic agent and blocks impulse domain potassium channel) TREK-1 with an IC of 402.7 μM. conduction in nerve fibres through inhibiting sodium ion 50 influx reversibly.

Purity: 99.97% Purity: 99.98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg 10 mg, 50 mg

Rotenone Rotigotine Cat. No.: HY-B1756 Cat. No.: HY-75502

Bioactivity: is an mitochondrial electron transport chain Bioactivity: Rotigotine is a full agonist of dopamine receptor, a complex I inhibitor. partial agonist of the 5-HT1A receptor, and an antagonist of

the α2B-adrenergic receptor, with Kis of 0.71nM, 4-15nM, and 83nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor. Purity: 98.0% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 10 mg, 50 mg, 100 mg

Rotigotine Hydrochloride Rotundine (Rotigotine HCl) Cat. No.: HY-A0007 ((-)-; L-Tetrahydropalmatine) Cat. No.: HY-N0096

Bioactivity: Rotigotine Hydrochloride is a full agonist of dopamine Bioactivity: Rotundine is an antagonist of dopamine D1, D2 and D3

receptor, a partial agonist of the 5-HT1A receptor, and an receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, antagonist of the α2B-adrenergic receptor, with Ki of 0.71nM, respectively. Rotundine is also an antagonist of 5-HT1A with 4-15nM, and 83nM for the dopamine D3 receptor and D2, D5, D4 an IC of 370 nM. receptors, and dopamine D1 receptor. 50 Purity: 99.99% Purity: 99.88% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg 50 mg

RPR104632 RS 127445 Cat. No.: HY-101600 (MT 500) Cat. No.: HY-15419

Bioactivity: RPR104632 is a specific antagonist of NMDA receptor, with Bioactivity: RS 127445 is a novel high affinity, selective 5-HT2B potent neuroprotective properties. receptor antagonist with pKi of 9.5.

Purity: >98% Purity: 99.68% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

124 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

RS 8359 RS102895 Cat. No.: HY-14260 Cat. No.: HY-18611A

Bioactivity: RS 8359 is a selective and reversible MAO-A inhibitor, with Bioactivity: RS102895 is a potent CCR2 antagonist, with an IC50 of 360 nM, antidepressant activity. and shows no effect on CCR1.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10 mg, 50 mg

RS102895 hydrochloride RT-AM Cat. No.: HY-18611 Cat. No.: HY-108715A

Bioactivity: RS102895 hydrochloride is a potent CCR2 antagonist, with an Bioactivity: RT-AM is a pro-drug real thiol. Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively IC50 of 360 nM, and shows no effect on CCR1. monitor the real-time glutathione dynamics in living cells.

Purity: 98.98% Purity: 98.01% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 1 mg

RT-NH2 RU 24969 (Real Thiol-NH2) Cat. No.: HY-103684 Cat. No.: HY-16688

Bioactivity: RT-NH2 is a RealThiol prototype without the carboxylic acid Bioactivity: RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B groups. RT-NH2 is fairly hydrophobic and cannot distribute in receptors. the nucleus, which is a hallmark of protein binding for fluorescent probe.

Purity: >98% Purity: 99.42% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Rufinamide Rutin hydrate (CGP 33101; E 2080; RUF 331) Cat. No.: HY-A0042 (Rutoside hydrate; 3-O-rutinoside hydrate) Cat. No.: HY-N0148A

Bioactivity: (E 2080; CGP 33101; RUF 331) is a new antiepileptic Bioactivity: Rutin hydrate is a flavonol glycoside, able to cross the agent that differs structurally from other antiepileptic drugs blood-brain barrier, and acts by inhibiting JNK and ERK1/2 and is approved as adjunctive therapy for Lennox-Gastaut activation and activating mTOR signalling. syndrome (LGS).

Purity: 99.89% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 g, 10 g 10 mg, 100 mg

Ruzadolane RWJ-51204 (UP 26-91) Cat. No.: HY-100294 Cat. No.: HY-19308

Bioactivity: Ruzadolane is a non-narcotic, centrally-acting analgesic Bioactivity: RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki agent. of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

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S 38093 S-8510 phosphate Cat. No.: HY-104003 (SB-737552 phosphate) Cat. No.: HY-103225

Bioactivity: S 38093 is a brain-penetrant antagonist of H3 receptor, with Bioactivity: S-8510 (phosphate) is an inverse Benzodiazepine (BDZ) receptor

Ki of 8.8, 1.44 and 1.2 µM for rat, mouse and human H3 agonist, with K is of 34.6 nM, 36.2 nM for –GABA and +GABA receptors, respectively. respectively.

Purity: 99.02% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

S-Adenosyl-L-methionine disulfate tosylate S-Allyl-L-cysteine Cat. No.: HY-W017770 Cat. No.: HY-W013573

Bioactivity: S-Adenosyl-L-methionine disulfate tosylate is the principal Bioactivity: S-Allyl-L-cysteine, one of the organosulfur compounds found in biological methyl donor synthesized in all mammalian cells but AGE, possess various biological effects including neurotrophic most abundantly in the liver. activity, anti-cancer activity, anti-inflammatory activity.

Purity: 97.0% Purity: 98.64% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg 10 mg, 25 mg, 50 mg, 100 mg

S-Methyl-L-cysteine S-MTC (L-S-Methylcysteine) Cat. No.: HY-B2188 Cat. No.: HY-U00432

Bioactivity: S-Methyl-L-cysteine is a natural product that acts as a Bioactivity: S-MTC is a selective type I nitric oxide synthase ( NOS) substrate in the catalytic antioxidant system mediated by inhibitor. methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

Purity: 95.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 5 mg, 10 mg, 25 mg 100 mg

S16961 S1RA (S169611) Cat. No.: HY-U00281 (E-52862) Cat. No.: HY-18099

Bioactivity: S16961 is a nicotinic receptor agonist. Bioactivity: S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

S1RA hydrochloride SA4503 (E-52862 hydrochloride) Cat. No.: HY-18099A (; AGY 94806) Cat. No.: HY-14813

Bioactivity: S1RA Hcl(E-52862 Hcl) is a potent and selective sigma-1 Bioactivity: SA4503(AGY-94806; Cutamesine) is a selective sigma 1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity receptor(σ1R) agonist; high affinity for the sigma 1 receptor against σ2R (Ki > 1000 nM). subtype labeled by (+)-[3H] (IC50 = 17.4 +/- 1.9 nM); 100-fold less affinity for the sigma 2 receptor.

Purity: 99.57% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

126 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

SA4503 dihydrochloride SA72 (AGY94806 dihydrochloride; Cutamesine dihydrochloride) Cat. No.: HY-13510 Cat. No.: HY-U00240

Bioactivity: SA4503 dihydrochloride is a potent σ1 receptor agonist with Bioactivity: SA72 is a highly selective fatty acid amide hydrolase (FAAH)

an IC50 of 17.4 nM in guinea pig brain membranes. inhibitor.

Purity: 98.74% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg

Sacubitrilat (LBQ-657) Cat. No.: HY-17620 (EMD 1195686; FCE 26743) Cat. No.: HY-70057

Bioactivity: Sacubitrilat is an active neprilysin ( NEP) inhibitor. Bioactivity: Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A.

Purity: 99.85% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg 10 mg, 50 mg

SAGE-217 Salbutamol Cat. No.: HY-103040 (Albuterol; AH-3365) Cat. No.: HY-B1037

Bioactivity: SAGE-217 is a potent GABAA receptor agonist with EC50s of Bioactivity: Salbutamol is a short-acting β2-adrenergic receptor agonist 296 and 163 nM for α β γ and α β δ GABA receptors, used for the relief of bronchospasm in conditions such as 1 2 2 4 3 A asthma and chronic obstructive pulmonary disease (COPD). respectively.

Purity: 99.93% Purity: >98% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Salsolidine SAR7334 hydrochloride (6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) Cat. No.: HY-22385 Cat. No.: HY-15699A

Bioactivity: Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a Bioactivity: SAR7334 hydrochloride is a potent and specific TRPC6 stereoselective competitive MAO A inhibitor. inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

Purity: 95.77% Purity: 95.30% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Saredutant (SR 48968; SR 48968C) Cat. No.: HY-106910 (Ro 15-3505) Cat. No.: HY-100248

Bioactivity: is a selective NK2 receptor antagonist. Bioactivity: Sarmazenil is a benzodiazepine receptor antagonist.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg, 10 mg

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SB 216763 SB 242084 Cat. No.: HY-12012 Cat. No.: HY-13409

Bioactivity: SB 216763 is potent and selective and ATP-competitive glycogen Bioactivity: SB 242084 is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B synthase kinase-3 (GSK-3) inhibitor, with an IC50 value of 34.3 nM for GSK-3α and GSK-3β, respectively. receptors respectively.

Purity: 96.90% Purity: 99.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

SB 242084 hydrochloride SB 258719 Cat. No.: HY-13409A Cat. No.: HY-U00443

Bioactivity: SB 242084 hydrochloride is a 5-HT2C receptor Bioactivity: SB 258719 is a selective 5-HT7 receptor antagonist with a antagonist(pKi=9.0) that displays 158- and 100-fold pK of 7.5. selectivity over 5-HT2A and 5-HT2B receptors respectively. i IC50 value: 9.0(pKi) [1] Target: 5-HT2C antagonist in vitro: SB 242084 had over 100-fold selectivity over a range of other… Purity: 98.58% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg

SB 271046 Hydrochloride SB 277011A dihydrochloride (SB 271046A) Cat. No.: HY-14336A Cat. No.: HY-10847A

Bioactivity: SB271046 Hcl is a potent, selective and orally active 5-HT6 Bioactivity: SB 277011A dihydrochloride is a potent, selective, orally

receptor antagonist with pKi of 8.9. bioavailable and brain penetrate dopamine D3 receptor

antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D 3, D

2, 5-HT 1B, and 5-HT 1D receptors, respectively. Purity: 99.06% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 10 mg, 50 mg

SB-222200 SB-224289 hydrochloride Cat. No.: HY-15722 (SB-224289A) Cat. No.: HY-101105A

Bioactivity: SB 222200 is a selective, reversible and competitive Bioactivity: SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively antagonist, with anxiolytic effect. crosses the blood-brain barrier.

Purity: 99.91% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg

SB-269970 SB-269970 hydrochloride Cat. No.: HY-15370 (SB-269970A) Cat. No.: HY-15370A

Bioactivity: SB269970 is a 5-HT7 receptor antagonist with pKi of 8.3, Bioactivity: SB269970 hydrochloride is a hydrochloride salt form of exhibits >50-fold selectivity against other receptors. SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors. IC50 Value: 8.3 (pKi for 5-HT7) [1] Target: 5-HT7 receptor in vitro: 5-CT-stimulated activity in guinea-pig… Purity: >98% Purity: 99.41% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

128 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

SB-277011 SB-334867 (SB-277011A) Cat. No.: HY-10847 (SB 334867A) Cat. No.: HY-10895

Bioactivity: SB-277011 is a potent and delective dopamine D3 receptor Bioactivity: SB-334867 is a selective non-peptide orexin OX1 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, antagonist with a pKb value of 7.2. IC50 value: 7.2 (pKb) [1] D2, 5-HT1D and 5-HT1B respectively); brain penetrant. Target: orexin OX1 receptor in vitro: SB-334867-A inhibited the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses (pK(B)=7.27+/-0.04 and 7.23+/-0.03 respectively,… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 5 mg, 10 mg, 50 mg

SB-334867 free base SB-399885 hydrochloride (SB334867A free base) Cat. No.: HY-10895A Cat. No.: HY-103099

Bioactivity: SB-334867 free base is a selective non-peptide orexin OX1 Bioactivity: SB-399885 hydrochloride is a 5-HT6 receptor antagonist. receptor antagonist with a pKb value of 7.2.

Purity: 99.77% Purity: 98.93% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

SB-408124 SB-408124 Hydrochloride Cat. No.: HY-70068 Cat. No.: HY-76612

Bioactivity: SB408124 is a non-peptide antagonist for OX1 receptor with Ki Bioactivity: SB408124 Hcl is a non-peptide antagonist for OX1 receptor with of 57 nM and 27 nM in both whole cell and membrane, Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor. respectively; exhibits 50-fold selectivity over OX2 receptor.

Purity: 98.27% Purity: 98.14% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

SB-616234A SB-674042 Cat. No.: HY-19477 Cat. No.: HY-10898

Bioactivity: SB-616234A is a selective and orally bioavailable 5-HT1B Bioactivity: SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist, with anxiolytic and antidepressant receptor antagonist (Kd = 3.76 nM); exhibits 100-fold activity. selectivity for OX1 over OX2 receptors.

Purity: >98% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

SB-705498 SB-742457 Cat. No.: HY-10633 (GSK-742457; RVT-101; ) Cat. No.: HY-14339

Bioactivity: SB-705498 is a potent, selective and orally bioavailable Bioactivity: SB742457 is a highly selective 5-HT6 receptor antagonist with transient receptor potential vanilloid 1 (TRPV1) receptor pKi of 9.63; exhibits >100-fold selectivity over other

antagonist with a pIC50 of 7.1. receptors.

Purity: 99.73% Purity: 98.92% Clinical Data: Phase 2 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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SB269652 SB297006 Cat. No.: HY-12324 Cat. No.: HY-103361

Bioactivity: SB269652 is the first drug-like allosteric modulator of the Bioactivity: SB297006 is a CCR3 antagonist, which significantly inhibits dopamine D2 receptor (D2R); a new chemical probe that can proliferation and neurosphere formation in CCL11-treated differentiate D2R monomers from dimers or oligomers depending neural progenitor cells. on the observed .

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

SCH 23390 hydrochloride Sch412348 (R-(+)-SCH23390 hydrochloride) Cat. No.: HY-19545A Cat. No.: HY-U00189

Bioactivity: SCH 23390 hydrochloride is a potent Bioactivity: Sch412348 is a potent competitive antagonist of the human adenosine A receptor ( K =0.6 nM) and has >1000-fold antagonist with Ki values of 0.2 and 0.3 nM for the D1 and D5. 2A i selectivity over all other adenosine receptors.

Purity: 99.31% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Sch59498 Schisandrin B Cat. No.: HY-U00374 (Schizandrin-B; Wuweizisu-B; gamma-Schisandrin) Cat. No.: HY-N0089

Bioactivity: Sch59498 is a potent inhibitor of phosphodiesterase 1c Bioactivity: Schisandrin B(Wuweizisu-B) is a dibenzocyclooctadiene (Pde1c). derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart. IC50 value: Target: in vitro: Schisandrin B exhibits anti-inflammatory activity through modulation of the… Purity: >98% Purity: 99.99% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Scopine Scopine hydrochloride (6,7-Epoxytropine) Cat. No.: HY-B0459 (6,7-Epoxytropine hydrochloride) Cat. No.: HY-B0459A

Bioactivity: Scopine is the metabolite of , which is a Bioactivity: Scopine Hcl salt is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. acute circulatory shock.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Scopolamine butylbromide (Hyoscine butylbromide; (Hyoscine; Scopine (-)-tropate; Scopine tropate) Cat. No.: HY-N0296 (-)-Scopolamine butylbromide; …) Cat. No.: HY-N0340

Bioactivity: Scopolamine is a high affinity (nM) muscarinic antagonist. Bioactivity: Scopolamine butylbromide is a competitive antagonist of

5-HT3 receptor-responses are reversibly inhibited by muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 Scopolamine with an IC of 2.09 μM. ± 4.3 nM. Target: mAChR Scopolamine (USAN), also known as 50 levo-duboisine and hyoscine, sold as Scopoderm, is a tropane alkaloid drug with muscarinic antagonist effects. It is among… Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

130 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Scopolamine hydrobromide ((-)-Scopolamine hydrobromide; Scopolamine N-oxide hydrobromide Hyoscine hydrobromide; Scopine hydrobromide) Cat. No.: HY-N0296A (Hyoscine N-oxide hydrobromide) Cat. No.: HY-B2146

Bioactivity: Scopolamine hydrobromide is a high affinity (nM) muscarinic Bioactivity: Scopolamine N-oxide hydrobromide is an antagonist of the muscarinic acetylcholine. antagonist. 5-HT3 receptor-responses are reversibly

inhibited by Scopolamine with an IC50 of 2.09 μM.

Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 100 mg

Scyliorhinin II SDZ 220-581 Cat. No.: HY-P1588 Cat. No.: HY-13059

Bioactivity: Scyliorhinin II is a selective neurokinin-3 receptor agonist, Bioactivity: SDZ 220-581 is a potent, competitive antagonist at the NMDA glutamate receptor subtype(pKi= 7.7). with a Ki of 2.5 nM for neurokinin-3 receptor in rat .

Purity: >98% Purity: 98.15% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

SDZ 220-581 Ammonium salt SDZ 220-581 hydrochloride Cat. No.: HY-13059A Cat. No.: HY-13059B

Bioactivity: SDZ 220-581 ammonium salt is a potent, competitive antagonist Bioactivity: SDZ 220-581 Hcl is a potent, competitive antagonist at the at the NMDA glutamate receptor subtype(pKi= 7.7). IC50 Value: NMDA glutamate receptor subtype(pKi= 7.7). Target: NMDA receptor in vitro: Wake-promoting doses of LSN2463359 and LSN2814617 attenuated deficits in performance induced by the competitiveNMDA receptor antagonist SDZ 220,581… Purity: >98% Purity: 96.13% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Secretin (28-54), human (33-59), rat (Human secretin) Cat. No.: HY-P1465 (Secretin (rat)) Cat. No.: HY-P1244

Bioactivity: Secretin (28-54), human is a 27-amino acid residue Bioactivity: Secretin (33-59), rat is a 27-aa peptide, acts on secretin C-terminally amidated peptide, which acts on secretin receptor, enhances the secretion of bicarbonate, enzymes, and receptors. K + from the pancreas.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Semagacestat Senktide (LY450139) Cat. No.: HY-10009 Cat. No.: HY-P0187

Bioactivity: is a γ-secretase inhibitor, inhibits Bioactivity: Senktide is a tachykinin NK3 receptor agonist. Sequence: β-amyloid ( Aβ42), Aβ38 and Aβ40 with IC of 10.9, 12 50 Suc-Asp-{Me-Phe}-Phe-Gly-Leu-Met-NH2. and 12.1 nM, respectively; also inhibits Notch signaling with

IC50 of 14.1 nM. Purity: 98.83% Purity: 99.56% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg, 100 mg

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Serlopitant Serotonin hydrochloride (VPD-737; MK-0594) Cat. No.: HY-12114 (5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride) Cat. No.: HY-B1473

Bioactivity: Serlopitant is a selective Neurokinin-1 (NK-1) receptor Bioactivity: Serotonin hydrochloride is a monoamine neurotransmitter in the antagonist. CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (

COMT) inhibitor with a Ki of 44 μM.

Purity: >98% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg

Sertindole hydrochloride (Lu 23-174) Cat. No.: HY-14543 Cat. No.: HY-B0176A

Bioactivity: , a neuroleptic, is one of the newer antipsychotic Bioactivity: Sertraline hydrochloride is an antidepressant of the selective medications available. Target: Multi-target In vitro studies serotonin reuptake inhibitor (SSRI) class. showed that sertindole exerts a potent antagonism at serotonin 5-HT2A, 5-HT2C, dopamine D2, and αl adrenergic receptors. Sertindole offers an alternative treatment option for… Purity: 96.14% Purity: 99.84% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

Setiptiline maleate (Org-8282) Cat. No.: HY-32329 (MO-8282) Cat. No.: HY-32329A

Bioactivity: Setiptiline(Org-8282) is a serotonin receptor antagonist. Bioactivity: Setiptiline is a serotonin receptor antagonist.

Purity: 96.00% Purity: 99.89% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Sigma-LIGAND-1 hydrochloride Cat. No.: HY-101626 (Cucoline hydrochloride) Cat. No.: HY-15122A

Bioactivity: Sigma-LIGAND-1 is a selective sigma receptor ligand, has Bioactivity: Sinomenine hydrochloride is a blocker of the NF-κB activation

receptor IC50s of 16 nM at the DTG site, 19 nM at the PPP and also an activator of μ-opioid receptor.

site, and a Ki of 4000 nM at the dopamine D2 receptor.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg

SIRT2 Inhibitor II SKF 38393 hydrochloride (AK-1) Cat. No.: HY-101465 ((±)-SKF-38393 hydrochloride; SKF-38393A) Cat. No.: HY-12520A

Bioactivity: AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor. Bioactivity: SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM. IC50 value: 110 nM [1] Target: D1 agonist in vitroL SKF 38393 hydrochloride is a selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of… Purity: 98.0% Purity: 99.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 50 mg, 100 mg, 200 mg, 500 mg

132 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

SKF 82958 SKF-82958 hydrobromide ((±)-SKF 82958; Chloro-AP) Cat. No.: HY-10435 ((±)-SKF 82958 hydrobromide; Chloro-APB hydrobromide) Cat. No.: HY-10435A

Bioactivity: SKF 82958 is a D1/D5 receptor full agonist. IC50 value: Bioactivity: SKF 82958 hydrobromide is a D1/D5 receptor full agonist. IC50 Target: D1/D5 receptor in vitro: Neuropeptide and immediate value: Target: D1/D5 receptor in vitro: Neuropeptide and early gene expression in striatonigral neurons of the immediate early gene expression in striatonigral neurons of normosensitive striatum is induced by mixed D1 receptor the normosensitive striatum is induced by mixed D1 receptor SKF-82958, which induces behavioral activity and… SKF-82958, which induces behavioral activity and… Purity: >98% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

SKF89976A hydrochloride Small Cardioactive Peptide B SCPB (d,l-SKF89976A hydrochloride) Cat. No.: HY-100228A Cat. No.: HY-P1495

Bioactivity: SKF89976A hydrochloride is a selective GABA transporter ( Bioactivity: Small Cardioactive Peptide B (SCP B), a neurally active GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 peptide, stimulates adenylate cyclase activity in particulate

μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively. fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively. Purity: 98.15% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg

SMND-309 sn-Glycero-3-phosphocholine Cat. No.: HY-13056 (Choline Alfoscerate; Alpha-GPC; L-α-GPC) Cat. No.: HY-17552

Bioactivity: SMND-309 is a novel derivative of salvianolic acid B, and has Bioactivity: L-Alpha glycerylphosphorylcholine (alpha-GPC, choline shown protective effects against rat cortical neuron damage in alfoscerate) is a natural choline compound found in the brain vitro and in vivo. and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia. IC50 value: Target: Anti-AD… Purity: 97.25% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg 1 g, 5 g, 10 g

Sodium Channel inhibitor 1 Sodium Channel inhibitor 2 Cat. No.: HY-15736 Cat. No.: HY-100257

Bioactivity: Sodium Channel inhibitor1, one of Bioactivity: Sodium Channel inhibitor 2 is a sodium channel blocker 3-Oxoisoindoline-1-carboxamides, is a novel and selective extracted from patent WO 2004011439 A2, compound 3c. voltage-gated sodium channel for pain treatment.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

Solifenacin hydrochloride (YM905) Cat. No.: HY-A0034 (YM905 hydrochloride) Cat. No.: HY-I0230

Bioactivity: Solifenacin is a novel muscarinic receptor antagonist with Bioactivity: Solifenacin Hcl(YM905 Hcl; Vesicare Hcl) is a muscarinic

pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptor antagonist. receptors, respectively.

Purity: 99.77% Purity: 99.22% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

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Solifenacin Succinate Somatostatin (YM905) Cat. No.: HY-A0002 Cat. No.: HY-P0015

Bioactivity: Solifenacin Succinate(YM905; Vesicare) is a muscarinic Bioactivity: Somatostatin is a tetradecapeptide which can suppress the receptor antagonist. IC50 value: Target: muscarinic receptor growth hormone (GH) secretion and control the pituitary Solifenacin succinate (YM905; Vesicare) is a prescription hormone secretion in human CNS. Sequence: H-Ala-Gly-Cys-Lys-As medication used to treat certain bladder problems. n-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH(Disulfide bridge: Cys3-Cys14). Purity: 99.99% Purity: 99.71% Clinical Data: Launched Clinical Data: Phase 4 Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg 10 mg, 50 mg, 100 mg

Somatostatin-28 1-12 Somatostatin-28 1-14 (1-12-Somatostatin-28) Cat. No.: HY-P1557 Cat. No.: HY-P1499

Bioactivity: Somatostatin-28 (1-12) is a somatostatin fragment that is Bioactivity: Somatostatin-28 (1-14) is an N-terminal fragment of the monitored in brain tissue to track processing of somatostatin. neuropeptide somatostatin-28.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

SPD-473 citrate Cat. No.: HY-101612 (Li 32-468; S 32-468; Substance 32468) Cat. No.: HY-101817

Bioactivity: SPD-473 citrate is a serotonin/ dopamine/ norepinephrine Bioactivity: Spirendolol is a β adrenergic receptor antagonist. reuptake inhibitior.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

SR-3306 SR144528 Cat. No.: HY-12829 Cat. No.: HY-13439

Bioactivity: SR-3306 is a selective, potent, highly brain penetrant JNK Bioactivity: SR144528 is a potent and selective CB2 receptor antagonist

inhibitor. with a Ki of 0.6 nM.

Purity: 97.91% Purity: 99.61% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

SR17018 SRI-011381 hydrochloride Cat. No.: HY-111454 Cat. No.: HY-100347A

Bioactivity: SR17018 is an mu-opioid-receptor (MOR) agonist, binding Bioactivity: SRI-011381 hydrochloride is a TGF-beta signaling agonist.

with GTPγS, with an EC50 of 97 nM.

Purity: 98.0% Purity: 99.66% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

134 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

SSD114 hydrochloride ST-836 Cat. No.: HY-103668A Cat. No.: HY-15238

Bioactivity: SSD114 hydrochloride is a novel GABAB receptor positive Bioactivity: ST-836 is a dopamine receptor ligand; Antiparkinsonian agent. allosteric modulator.

Purity: 99.07% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

ST-836 hydrochloride ST034307 Cat. No.: HY-15238A Cat. No.: HY-101279

Bioactivity: ST-836 Hcl is a dopamine receptor ligand; Antiparkinsonian Bioactivity: ST034307 is a potent and selective adenylyl cyclase 1 (AC1)

agent. inhibitor, with IC 50 of 2.3 μM.

Purity: 98.01% Purity: 98.11% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ST3932 ST4206 Cat. No.: HY-112840 Cat. No.: HY-U00341

Bioactivity: ST3932 is a metabolite of ST1535, acts as an antagonist of Bioactivity: ST4206 is a potent adenosine A2A antagonist, with Kis of 12 nM adenosine A receptor, with K s of 8 nM and 33 nM for A 2A i 2A and 197 nM for adenosine A2A receptor and adenosine A1

and A 1 receptors, respectively. receptor, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Stearoylethanolamide Cat. No.: HY-113015 (BCX2600) Cat. No.: HY-103392

Bioactivity: is an endocannabinoid-like compound with Bioactivity: Stiripentol (STP) is an anticonvulsant agent, which can pro-apoptotic activity. inhibit N-demethylation of CLB to NCLB mediatated by

CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki

of 1.59±0.07 and 0.516±0.065 μM and IC50 of 1.58 and 3.29 … Purity: >98% Purity: 99.97% Clinical Data: Clinical Data: Launched Size: Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Substance P Substance P (1-7)(TFA) (Neurokinin P) Cat. No.: HY-P0201 (Substance P (1-7) Trifluoroacetate) Cat. No.: HY-P1485A

Bioactivity: Substance P is a neuropeptide, acting as a neurotransmitter Bioactivity: Substance P (1-7)(TFA) is a fragment of the neuropeptide, and as a neuromodulator.The endogenous receptor for substance substance P (SP). Substance P (1-7)(TFA) gives depressor and P is neurokinin 1 receptor ( NK1-receptor, NK1R). Sequence: bradycardic effects when applied to the nucleus tractus Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. solitarius.

Purity: 98.07% Purity: 99.20% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 5 mg, 10 mg, 25 mg

www.MedChemExpress.com 135

Substance P 1-7 Substance P 7-11 Cat. No.: HY-P1485 Cat. No.: HY-P1492

Bioactivity: Substance P (7-11) is a fragment of the neuropeptide, Bioactivity: Substance P (7-11) is a C-terminal fragment of Substance P substance P (SP). Substance P (7-11) gives depressor and which can cause an increase in the intracellular calcium bradycardic effects when applied to the nucleus tractus concentration. solitarius.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 5 mg, 10 mg, 25 mg

Suclofenide sodium (Neosulfalepsine; PB385) Cat. No.: HY-U00102 (Org25969) Cat. No.: HY-B0079

Bioactivity: Suclofenide (Neosulfalepsine;PB385) is an anticonvulsant Bioactivity: Sugammadex sodium is a synthetic γ-cyclodextrin derivative, agent. and acts as a new reversal agent for neuromuscular block.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Sulbutiamine Sulforhodamine 101 (Bisibuthiamine) Cat. No.: HY-B2229 (SR101) Cat. No.: HY-101878

Bioactivity: Sulbutiamine is a highly lipid soluble synthetic analogue of Bioactivity: Sulforhodamine 101 is a red fluorescent dye. vitamin B1, used for the treatment of asthenia.

Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 25 mg 1 g, 5 g

Sulindac sulfide Sulpiride (cis- sulfide) Cat. No.: HY-B1786 Cat. No.: HY-B1019

Bioactivity: Sulindac sulfide is a noncompetitive γ-secretase inhibitor, Bioactivity: Sulpiride is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class, used mainly in the with an IC50 of 20.2 μM for γ 42-secretase activity. treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. Purity: >98% Purity: 99.99% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg

Sultiame Cat. No.: HY-108316 Cat. No.: HY-42849

Bioactivity: is a carbonic anhydrase inhibitor, widely used as an Bioactivity: Sultopride is a selective antagonist of dopamine D2 antiepileptic drug. receptor.

Purity: 99.11% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg, 50 mg 5 mg

136 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Sultopride hydrochloride maleate Cat. No.: HY-42849A (U95666E; PNU 95666; PNU 95666E; Sumanirole) Cat. No.: HY-70081A

Bioactivity: Sultopride hydrochloride is a selective antagonist of Bioactivity: Sumanirole maleate(PNU 95666E; U95666E) is a highly selective dopamine D2 receptor. D2 receptor full agonist with an ED50 of about 46 nM. IC50 value: 46 nM (EC50) Target: D2 receptor Sumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for… Purity: 83.20% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 25 mg, 50 mg, 100 mg

SUN11602 Cat. No.: HY-101493 (DM-235) Cat. No.: HY-17550

Bioactivity: SUN11602 is a novel aniline compound with basic fibroblast Bioactivity: Sunifiram (DM-235) is a piperazine derived ampakine-like drug growth factor-like activity. which has nootropic effects in animal studies with significantly higher potency than piracetam.

Purity: 98.02% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg

SX-3228 SYM2206 Cat. No.: HY-100291 Cat. No.: HY-18689

Bioactivity: SX-3228 is a selective benzodiazepine1 ( BZ1) receptor agonist Bioactivity: SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50= 2.8 μM). with an IC50 of 17 nM.

Purity: >98% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Synephrine hydrochloride Synta66 (Oxedrine hydrochloride) Cat. No.: HY-N0132A Cat. No.: HY-111325

Bioactivity: Hcl(Oxedrine) is an alkaloid; synephrine produces Bioactivity: Synta66 is an inhibitor of store-operated calcium entry most of its biological effects by acting as an agonist at channel Orai, which forms the pore of the CRAC channel, and adrenergic receptors. used for the research of neurological disease.

Purity: 99.83% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg, 25 mg

Syntide 2 SZ1676 Cat. No.: HY-P0271 Cat. No.: HY-U00162

Bioactivity: Syntide 2 is recognized as a substrate by Ca Bioactivity: SZ1676 is a derivative of SZ1677, which is a neuromuscular 2+/calmodulin-dependent protein kinase II ( CaMKII) with blocking agent.

a Ki of 12 μM. Sequence: Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

www.MedChemExpress.com 137

T 82 T807 Cat. No.: HY-U00028 (AV-1451) Cat. No.: HY-101184

Bioactivity: T 82 is a potent 5-HT3 antagonist and acetylcholinesterase Bioactivity: T807 a novel tau positron emission tomography (PET) tracer. (AChE) inhibitor, used for treatment of Alzheimer's Disease.

Purity: >98% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Tachykinin angatonist 1 hydrochloride hydrate Cat. No.: HY-U00392 Cat. No.: HY-B2244

Bioactivity: Tachykinin angatonist 1 is a neurokinin receptor antagonist Bioactivity: Tacrine hydrochloride hydrate is an inhibitor of both acetyl (

extracted from patent US5968923, compound example 32. AChE) and butyryl-cholinestrase ( BChE) with IC50s of 31 nM and 25.6 nM, respectively.

Purity: >98% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg

Tafamidis (Fx-1006A) Cat. No.: HY-14852 (GYKI-53773; LY-300164) Cat. No.: HY-15079

Bioactivity: (Fx1006A) is a potent and selective transthyretin Bioactivity: Talampanel is a potent and selective AMPA-receptor antagonist, kinetic stabilizer that inhibits the amyloid cascade. Target: is a potential new antiepileptic drug (AED). Others Tafamidis is a drug for the amelioration of transthyretin-related hereditary amyloidosis.Tafamidis functions by kinetic stabilization of the correctly folded… Purity: 99.61% Purity: 98.59% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Talipexole Talnetant (B-HT 920) Cat. No.: HY-A0040 (SB 223412) Cat. No.: HY-14552

Bioactivity: Talipexole (B-HT920) is a dopamine agonist that has been Bioactivity: Talnetant (SB 223412) is a potent and selective NK3 receptor proposed as an antiparkinsonian agent. Target: Dopamine antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the Receptor B-HT920 is a selective alpha 2-adrenoceptor agonist. hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at The effects of B-HT920 have been specified using the concentrations up to 100 uM. alpha-adrenergic antagonists yohimbine and and the… Purity: >98% Purity: 99.27% Clinical Data: Launched Clinical Data: Phase 2 Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Talnetant hydrochloride (SB 223412 hydrochloride; SB 223412-A) Cat. No.: HY-14552A (TA-0910) Cat. No.: HY-B0596

Bioactivity: Talnetant Hcl(SB 223412 Hcl) is a potent and selective NK3 Bioactivity: Taltirelin(TA0910), a novel orally active TRH analogue, binds receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective to rat brain TRH receptors in vivo. for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM.

Purity: >98% Purity: 98.96% Clinical Data: Phase 2 Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

138 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Tandospirone citrate (SM-3997) Cat. No.: HY-14558 (SM-3997 citrate) Cat. No.: HY-B0061

Bioactivity: Tandospirone(SM-3997) is a potent and selective 5-HT1A Bioactivity: Tandospirone citrate is a potent and selective 5-HT1A receptor receptor partial agonist (Ki = 27 nM) that displays partial agonist (Ki = 27 nM) that displays selectivity over selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging values ranging from 1300-41000 nM). from 1300-41000 nM).

Purity: 96.81% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 10 mg, 50 mg

Tarafenacin Tarafenacin D-tartrate (SVT-40776) Cat. No.: HY-14825 (SVT-40776 D-tartrate) Cat. No.: HY-14825A

Bioactivity: Tarafenacin(SVT-40776) is a highly selective M3 muscarinic Bioactivity: Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor. M2 receptor.

Purity: >98% Purity: 99.70% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Taranabant racemate (MK-0364 racemate) Cat. No.: HY-10013A (BMS-214778; VEC-162) Cat. No.: HY-14803

Bioactivity: racemate is an antagonist and/or inverse agonist of Bioactivity: Tasimelteon is a melatonin MT1 and MT2 receptor agonist. the Cannabinoid-1 ( CB1) receptor extracted from patent WO 2004048317 A1.

Purity: 99.74% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

Tat-NR2B9c TB5 Cat. No.: HY-P0117 Cat. No.: HY-100975

Bioactivity: Tat-NR2B9c is a 20-aa peptide, which acts as a postsynaptic Bioactivity: TB5 is a potent, selective and reversible inhibitor of

density-95 ( PSD-95) inhibitor, with an EC50 of 6.7 nM for hMAO-B with a Ki value of 0.11±0.01 μM. PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1; Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy. Sequence: Tyr-Gly-Arg-Lys-… Purity: 98.22% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

TBPB TCB2 Cat. No.: HY-14562 Cat. No.: HY-103102

Bioactivity: TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that Bioactivity: TCB2 is an agonist of serotonin 5-HT2A receptor. regulates amyloid processing and produces antipsychotic-like activity in rats.

Purity: 99.92% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg

www.MedChemExpress.com 139

tCFA15 TCN238 Cat. No.: HY-104031 Cat. No.: HY-14419

Bioactivity: tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol Bioactivity: TCN238 is a positive allosteric mGlu4 receptor modulator containing 15 carbon atoms on the side chain, promotes the with an EC50 of 1 μM. differentiation of neurons, and may regulates Notch signaling.

Purity: >98% Purity: 99.74% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

TCS 1102 TDN345 Cat. No.: HY-10900 Cat. No.: HY-101669

Bioactivity: TCS 1102 is a potent, dual orexin receptor antagonist (Ki Bioactivity: TDN345 is a Ca2+ antagonist, used for the treatment of values are 0.2 and 3 nM for OX2 and OX1 receptors vascular and senile dementia including Alzheimer's disease. respectively).

Purity: 99.77% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg

Tebanicline hydrochloride Tecadenoson (Ebanicline hydrochloride; ABT-594 hydrochloride) Cat. No.: HY-14316A (CVT-510) Cat. No.: HY-19661

Bioactivity: hydrochloride (ABT594 hydrochloride) is a nAChR Bioactivity: Tecadenoson (CVT-510) is a selective A1 adenosine receptor modulator with potent, orally effective analgesic activity. It agonist. inhibits the binding of to α4β2 neuronal nAChRs with

a Ki of 37 pM.

Purity: 98.00% Purity: 99.64% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Tedatioxetine hydrobromide maleate (Lu AA 24530 hydrobromide) Cat. No.: HY-101755 (SDZ-HTF-919; HTF-919) Cat. No.: HY-14153A

Bioactivity: hydrobromide acts as a triple reuptake inhibitor Bioactivity: Tegaserod maleate is a partial agonist of the 5-HT4 receptor;

and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor stimulates the peristaltic reflex and accelerates antagonist. gastrointestinal transit.

Purity: >98% Purity: 99.80% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Telotristat Temanogrel (LP-778902) Cat. No.: HY-13055B (APD791) Cat. No.: HY-10560

Bioactivity: Telotristat (LP-778902) is a potent tryptophan hydroxylase Bioactivity: Temanogrel is a highly selective 5-HT2A receptor antagonist inhibitor with an in vivo IC50 of 0.028 μM. with a Ki of 4.9 nM.

Purity: 99.46% Purity: 98.14% Clinical Data: Phase 3 Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg 1 mg, 5 mg, 10 mg

140 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Temiverine hydrochloride Teprenone Cat. No.: HY-U00055 (Geranylgeranylacetone) Cat. No.: HY-B0779

Bioactivity: Temiverine hydrochloride is a synthesized drug that is Bioactivity: Teprenone is a anti-ulcer drug, and works as an inducer of expected to have anticholinergic action. heat shock proteins ( HSPs).

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Tetrabenazine Racemate (Ro 1-9569) Cat. No.: HY-B0590 (Ro 1-9569 Racemate) Cat. No.: HY-B0590A

Bioactivity: Tetrabenazine is a VMAT-inhibitor used for treatment of Bioactivity: Tetrabenazine (Racemate) is a selective and reversible hyperkinetic movement disorder. Target: Others tetrabenazine inhibitor of vesicular monoamine transporter-2 (VMAT-2). (TBZ), a monoamine-depleting and a dopamine-receptor-blocking drug. TBZ is an effective and safe drug for the treatment of a variety of hyperkinetic movement disorders. In contrast to… Purity: 99.10% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Tetracaine hydrochloride (Amethocaine) Cat. No.: HY-A0079 (Amethocaine hydrochloride) Cat. No.: HY-B0473

Bioactivity: Tetracaine is a topical local anesthetic for the eyes; works Bioactivity: Tetracaine HCl is a potent local anaesthetic and a channel by interfering with entry of sodium ions into nerve cells. function allosteric inhibitor.

Purity: 98.03% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg 1 g, 5 g

Tetrahydroberberine Tetrahydropalmatine () Cat. No.: HY-N0925 (DL-Tetrahydropalmatine) Cat. No.: HY-N0300

Bioactivity: Tetrahydroberberine is an isoquinoline alkaloid isolated from Bioactivity: Tetrahydropalmatine, an active component isolated from corydalis tuber; has micromolar affinity for dopamine D(2) corydalis, acts through inhibition of amygdaloid release of (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but dopamine to inhibit an epileptic attack in rats. moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00). Purity: 99.88% Purity: 99.07% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 10 mg, 50 mg

Tezosentan TG6-10-1 Cat. No.: HY-17351 Cat. No.: HY-16978

Bioactivity: is an endothelin (ET) receptor antagonist, with Bioactivity: TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist

pA2s of 9.5, 7.7 for ET A and ET B receptors, activity against only EP2, >300-fold selectivity over human respectively. EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.

Purity: >98% Purity: 99.28% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

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TH-237A (meso-GS 164) Cat. No.: HY-11054 (3,7-Dimethylxanthine) Cat. No.: HY-N0138

Bioactivity: TH-237A(meso-GS 164) is a novel neuroprotective agent Bioactivity: Theobromine is a methylxanthine found in cacao beans which can exhibiting favorable permeation across the blood brain inhibit adenosine receptor A1 ( AR1) signaling. barrier.

Purity: 98.49% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg

Thiamine hydrochloride (Vitamin B1 hydrochloride; Thiamine Thiamine monochloride chloride hydrochloride) Cat. No.: HY-N0680 (Vitamin B1) Cat. No.: HY-A0100

Bioactivity: Thiamine hydrochloride is an essential micronutrient needed as Bioactivity: Thiamine monochloride (Vitamin B1) is an essential cofactor for many central metabolic enzymes. that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives.

Purity: 99.50% Purity: 98.16% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 1 g 1 g

Thiopropazate hydrochloride (Thiopropazat; Perphenazine acetate) Cat. No.: HY-101614 Cat. No.: HY-B0965

Bioactivity: is a typical antipsychotic of the phenothiazine Bioactivity: Thioridazine is an antipsychotic drug, used in the treatment class. It is a prodrug to Perphenazine. Perphenazine is a of schizophrenia and psychosis, shows D4 selectivity or typical antipsychotic drug. serotonin antagonism.

Purity: 98.0% Purity: 99.93% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

THK5351 THK5351 R enantiomer Cat. No.: HY-101183 Cat. No.: HY-101183A

Bioactivity: THK5351 can be radiolabeled and used as a radiotracer for in Bioactivity: THK5351 R enantiomer is an R enantiomer of THK5351. vivo imaging of tau pathology in the brain.

Purity: 98.55% Purity: 95.0% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg Size: 1 mg, 5 mg, 10 mg

Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) Cat. No.: HY-P1529 (NO050328; NO328; TGB) Cat. No.: HY-B0696

Bioactivity: Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) is a Bioactivity: Tiagabine(NO328) is a selective gamma-aminobutyric acid (GABA) physiological metabolite of Thyrotropin-Releasing Hormone. reuptake inhibitor.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mg, 25 mg, 50 mg, 100 mg Size: 10 mg, 50 mg, 100 mg

142 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Tiagabine hydrochloride (NO050328 hydrochloride; NO328 hydrochloride; TGB hydrochloride) Cat. No.: HY-B0696A Cat. No.: HY-90003

Bioactivity: Tiagabine hydrochloride(NO328 hydrochloride) is a selective Bioactivity: Tianeptine is a selective facilitator of 5-HT uptake in vitro gamma-aminobutyric acid (GABA) reuptake inhibitor. and in vivo.

Purity: 98.20% Purity: 99.69% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

Tianeptine sodium salt hydrochloride Cat. No.: HY-90003A Cat. No.: HY-B1196

Bioactivity: Tianeptine sodium salt is a selective facilitator of 5-HT Bioactivity: Tiapride hydrochloride is a drug that selectively blocks D2 uptake in vitro and in vivo. IC50 Value: Target: 5-HT Receptor and D3 dopamine receptors in the brain. It is used to treat a Tianeptine has no affinity for a wide range of receptors, variety of neurological and psychiatric disorders including including 5-HT and dopamine (IC50 > 10 μM) and has no dyskinesia, alcohol withdrawal syndrome. effect on noradrenalin or dopamine uptake. Antidepressant,… Purity: 99.88% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg 10 mg, 50 mg, 100 mg

Tideglusib Tilapertin (NP-12; NP031112) Cat. No.: HY-14872 (AMG747) Cat. No.: HY-19887

Bioactivity: Tideglusib is an irreversible GSK-3 inhibitor with IC50s of 5 Bioactivity: Tilapertin is an oral inhibitor of type-1 ( GlyT1). nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.

Purity: 99.81% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg, 100 mg

Timosaponin AIII Cat. No.: HY-N0810 (BL-5111) Cat. No.: HY-100255

Bioactivity: Timosaponin AIII could inhibit acetylcholinesterase (AChE) Bioactivity: Tiodazosin is a potent competitive postsynaptic alpha

activity, with an IC50 of 35.4 μM. adrenergic receptor antagonist.

Purity: 98.88% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg

Tiotropium Bromide hydrate (Tiopropium) Cat. No.: HY-17360 Cat. No.: HY-B0460

Bioactivity: Tiotropium Bromide is a muscarinic acetylcholine receptor Bioactivity: Tiotropium Bromide hydrate is an anticholinergic and (mAChR) antagonist that blocks the binding of the bronchodilator and a muscarinic receptor antagonist. acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

Purity: 99.61% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 200 mg

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Tirasemtiv (CK-2017357) Cat. No.: HY-15964 Cat. No.: HY-B0194

Bioactivity: Tirasemtiv is an activator of the fast skeletal muscle Bioactivity: Tizanidine is an α2-adrenergic receptor agonist and inhibits troponin complex. neurotransmitter release from CNS noradrenergic neurons.

Purity: 99.90% Purity: >98% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Tizanidine hydrochloride TM-N1324 Cat. No.: HY-B0194A Cat. No.: HY-108699

Bioactivity: Tizanidine hydrochloride is an α2-adrenergic receptor agonist Bioactivity: TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 ( and inhibits neurotransmitter release from CNS noradrenergic 2+ GPR39) with EC50s of 9 nM/5 nM in the presence of Zn , neurons. and 280 nM/180 nM in the absence of Zn 2+ for human/murine GPR39. Purity: 99.48% Purity: 98.91% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

TMP778 Cat. No.: HY-102075 (Ro 40-7592) Cat. No.: HY-17406

Bioactivity: TMP778 is a potent and selevtive RORγt inverse agonist, with Bioactivity: Tolcapone(Ro 40-7592) is an orally active selective, potent

an IC 50 of 7 nM in FRET assay. catechol-O-methyltransferase (COMT) inhibitor.

Purity: >98% Purity: 99.52% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Tolperisone hydrochloride Tolterodine ((R)-(+)-Tolterodine; (+)-Tolterodine; Cat. No.: HY-B1139 (R)-Tolterodine; PNU-200583) Cat. No.: HY-A0024

Bioactivity: hydrochloride is a centrally acting muscle Bioactivity: Tolterodine(PNU-200583) is a potent muscarinic receptor relaxant, is indicated for use in the treatment of antagonists that show selectivity for the urinary bladder over pathologically increased tone of the cross-striated muscle salivary glands in vivo. caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and… Purity: 99.70% Purity: 94.20% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

Tolterodine Tartrate Tonabersat (Detrol LA; Kabi-2234; PNU-200583E) Cat. No.: HY-90010 (SB-220453) Cat. No.: HY-15204

Bioactivity: Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent Bioactivity: Tonabersat is a gap-junction modulator. muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value: Target: mAChR in vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by… Purity: 99.57% Purity: 98.48% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 25 mg, 50 mg, 100 mg, 250 mg 5 mg, 10 mg, 50 mg

144 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Topiramate Toreforant (McN 4853; RWJ 17021) Cat. No.: HY-B0122 (JNJ-38518168) Cat. No.: HY-16756

Bioactivity: is an anticonvulsant that antagonizes GluR5 Bioactivity: Toreforant is a potent and selective histamine H 4 receptor ( receptors and acts as a positive allosteric modulator of GABA H4R) antagonist, with a K at the human receptor of 8.4 nM. receptor-mediated currents. i

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 100 mg, 500 mg

Tozadenant TPA 023 (SYN115) Cat. No.: HY-10995 Cat. No.: HY-101640

Bioactivity: Tozadenant is an adenosine A2A receptor antagonist, with Ki Bioactivity: TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki

of 11.5 nM on human A 2A and 6 nM on rhesus A 2A. of 0.19-0.41 nM.

Purity: 98.06% Purity: 99.49% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

TPPB Tradipitant Cat. No.: HY-12359 (VLY-686; LY686017) Cat. No.: HY-16732

Bioactivity: TPPB is a cell-permeable benzolactam-derived protein kinase C Bioactivity: Tradipitant is a neurokinin-1 ( NK-1) antagonist.

( PKC) activator with a Ki of 11.9 nM.

Purity: 99.81% Purity: 99.62% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

TRAM-34 hemisulfate (dl-Tranylcypromine hemisulfate; Cat. No.: HY-13519 trans-2-Phenylcyclopropylamine hemisulfate salt) Cat. No.: HY-B1496

Bioactivity: TRAM-34 is a highly selective blocker of Bioactivity: Tranylcypromine hemisulfate is an irreversible, nonselective intermediate-conductance calcium-activated K + channel ( MAO inhibitor used in the treatment of depression.

IKCa1) ( Kd=20 nM).

Purity: 99.71% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg 100 mg

Traxoprodil hydrochloride Cat. No.: HY-W018061 Cat. No.: HY-B0478

Bioactivity: (CP101,606) is a potent and selective NMDA Bioactivity: Trazodone HCl is an antidepressant belonging to the class of

antagonist and protect hippocampal neurons with an IC50 of 10 serotonin receptor antagonists and reuptake inhibitors for nM. treatment of anxiety disorders.

Purity: 99.43% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 100 mg, 500 mg

www.MedChemExpress.com 145

TRC051384 dihydrochloride Cat. No.: HY-101712 (TFP; SKF5019) Cat. No.: HY-B0532A

Bioactivity: TRC051384 is a 70 ( HSP70) inducer. Bioactivity: Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.

Purity: 97.40% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg 100 mg, 500 mg

Triflupromazine hydrochloride hydrochloride Cat. No.: HY-B0909 Cat. No.: HY-B1277

Bioactivity: hydrochloride is an antipsychotic medication, Bioactivity: Trihexyphenidyl hydrochloride is an antiparkinsonian agent of which are Dopamine D1/D2 receptor antagonists. the antimuscarinic class, binds to the M1 muscarinic receptor.

Purity: 99.94% Purity: 99.43% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 1 g

Trimipramine maleate TRO 19622 Cat. No.: HY-B1213 (Olesoxime; NSC 21311) Cat. No.: HY-14796

Bioactivity: maleate is a 5-HT receptor antagonist, with pK is Bioactivity: TRO 19622 is a mitochondrial-targeted neuroprotective compound with mean EC value for increasing cell survival of 6.39, 8.10, 4.66 for 5-HT 1C, 5-HT 2 and 5-HT 1A, 50 respectively. is 3.2±0.2 µM.

Purity: 98.0% Purity: 98.81% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg

Trofinetide (NNZ-2566) Cat. No.: HY-16757 (Ro 1-7683) Cat. No.: HY-B0321

Bioactivity: , a synthetic analogue of the endogenous N-terminus Bioactivity: Tropicamide is an anticholinergic and a muscarinic receptor tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to subtype M4-preferring antagonist . be neuroprotective in animal models of brain injury.

Purity: 98.0% Purity: 99.06% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg

Tropisetron Hydrochloride (SDZ-ICS 930) Cat. No.: HY-B0072 (SDZ-ICS 930) Cat. No.: HY-B0020

Bioactivity: Tropisetron(SDZ-ICS 930) is a selective 5-HT3 receptor Bioactivity: Tropisetron is a selective 5-HT3 receptor antagonist and antagonist and α7-nicotinic receptor agonist with an IC50 of α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM 70.1 ± 0.9 nM for 5-HT3 receptor. for 5-HT3 receptor.

Purity: 98.0% Purity: 99.64% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

146 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Trospium chloride Troxerutin Cat. No.: HY-B0461 (Trihydroxyethylrutin) Cat. No.: HY-N0139

Bioactivity: is a competitive muscarinic cholinergic Bioactivity: Troxerutin, also known as vitamin P4, is a receptor antagonist. tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species ( ROS) and depress ER stress-mediated NOD activation.

Purity: 99.14% Purity: 98.05% Clinical Data: Launched Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 100 mg, 5 g

TRPM8 Antagonist TTA-Q6 Cat. No.: HY-112430 Cat. No.: HY-10388

Bioactivity: TRPM8 Antagonist is a potent and selective TRPM8 Bioactivity: TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in antagonist, with an IC50 of 0.2 nM, used in the research of the neurological disease. neuropathic pain syndromes.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

TVP1022 TVP1022 mesylate ((S)-Rasagiline; S-PAI) Cat. No.: HY-14200 ((S)-Rasagiline mesylate; S-PAI mesylate) Cat. No.: HY-14200A

Bioactivity: TVP1022 is the S-isomer of rasagiline, which is an Bioactivity: TVP1022 mesylate is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. MAO-B inhibitor.

Purity: 99.60% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 25 mg

TWS119 Tyr-Gly-Gly-Phe-Met-OH Cat. No.: HY-10590 (Met-; Methionine enkephalin) Cat. No.: HY-P0073

Bioactivity: TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 Bioactivity: Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and nM, and activates the wnt/β-catenin pathway. inhibits tumor growth via binding to the opioid receptor.Sequence: Tyr-Gly-Gly-Phe-Met.

Purity: 98.0% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 25 mg, 50 mg, 100 mg

Tyramine U-101017 Cat. No.: HY-W007606 (PNU 101017) Cat. No.: HY-19250

Bioactivity: is an indirectly acting sympathomimetic amine that Bioactivity: U-101017 is a partial agonist of benzodiazepine receptor and releases norepinephrine from presynaptic nerve terminals. GABAA receptor, with anxiolytic effects.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g

www.MedChemExpress.com 147

U18666A U91356 Cat. No.: HY-107433 Cat. No.: HY-U00227

Bioactivity: U18666A, a cell permeable drug, is a synthesis and Bioactivity: U91356 is a dopamine receptor agonist. transport inhibitor.

Purity: 95.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg

U93631 Cat. No.: HY-100686 (MK-1602) Cat. No.: HY-12366

Bioactivity: U93631 is a GABAA receptor ligand of novel chemical structure Bioactivity: Ubrogepant (MK-1602) is a novel oral calcitonin gene-related with IC50 of 100 nM,and has been shown to induce a rapid, peptide receptor ( CGRP) antagonist in development for acute time-dependent decay of GABA-induced whole-cell Cl-currents in treatment of migraine [1]. recombinant GABAA receptors.

Purity: 99.92% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

UCPH-101 UK-240455 Cat. No.: HY-10914 Cat. No.: HY-19391

Bioactivity: UCPH-101 is an excitatory subtype 1 ( Bioactivity: UK-240455 is a potent and selective N-methyl D-aspartate ( NMDA) glycine site antagonist. EAAT1) inhibitor with an IC50 of 0.66 μM.

Purity: 99.12% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Uldazepam UPF-648 (U31920) Cat. No.: HY-100264 Cat. No.: HY-15600

Bioactivity: is a benzodiazepine derivative and can be used to Bioactivity: UPF-648 is a potent kynurenine 3-monooxygenase (KMO) treat patients with anxiety syndromes as tranquilizer. inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity.

Purity: >98% Purity: 99.12% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

UPF-648 sodium salt Cat. No.: HY-15600B Cat. No.: HY-B0716

Bioactivity: UPF-648 sodium salt is a potent kynurenine 3-monooxygenase Bioactivity: Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO receptor agonist. inhibition); ineffective at blocking KAT activity.

Purity: >98% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 50 mg

148 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

URB-597 Urinary Incontinence-Targeting Compound 1 (KDS-4103) Cat. No.: HY-10864 Cat. No.: HY-U00357

Bioactivity: URB597 is a potent, orally bioavailable FAAH inhibitor with Bioactivity: Urinary Incontinence-Targeting Compound 1 is a sulfonanilide IC50 of 4.6 nM, with no activity on other cannabinoid-related derivative, used in the research of urinary incontinence. targets. IC50 value: 4.6 nM [1] Target: FAAH in vitro: URB597 binds in the hydrophobic pocket and catalytic core of FAAH that connects the active site residues to the membrane surface… Purity: 98.71% Purity: >98% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

URMC-099 , human (Urocortin (human); Human urocortin; Human Cat. No.: HY-12599 urocortin 1; Human urocortin I) Cat. No.: HY-P1295

Bioactivity: URMC-099 is an orally bioavailable, brain penetrant inhibitor Bioactivity: Urocortin, human, a 40-aa neuropeptide, acts as a selective

of Mixed Lineage Kinase 3(MLK3) with IC50 of 14 nM; inhibits agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, LPS-induced TNFα release in microglial cells, HIV-1 and 0.5 nM for hCRF , rCRF and mCRF , respectively. Tat-induced release of cytokines in human monocytes, and 1 2α 2β up-regulation of phospho-JNK in Tat-injected brains of mice.… Purity: 99.78% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg, 50 mg, 100 mg

Urocortin, rat Urotensin II, mouse (Urocortin (Rattus norvegicus); Rat urocortin; ) Cat. No.: HY-P1296 Cat. No.: HY-P1483

Bioactivity: Urocortin, rat is a selective agonist of CRF receptor, with Bioactivity: Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Kis of 0.32, 2.2, and 0.62 nM for hCRF 1, rCRF 2α and mCRF

2β, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg

Vabicaserin hydrochloride Vafidemstat (SCA 136) Cat. No.: HY-111200 (ORY-2001) Cat. No.: HY-112623

Bioactivity: hydrochloride is a 5-hydroxytryptamine 2C ( Bioactivity: Vafidemstat is a dual -specific histone demethylase (

5-HT2C) receptor-selective agonist with an EC50 of 8 nM. LSD1)/ MAO-B inhibitor.

Purity: 99.74% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 250 mg, 500 mg

Valbenazine (NBI-98854) Cat. No.: HY-16771 Cat. No.: HY-P1599

Bioactivity: is a prodrug of the (+)-α isomer of tetrabenazine Bioactivity: Valorphin is an endogenous hemoglobin β-chain (33-39) fragment for tardive syndrome therapy, and inhibits VMAT2 function. with opioid analgesic activity, binds to rat mu-opioid

receptor, with an IC50 of 14 nM; Valorphin also shows anti-tumor activity.

Purity: 96.33% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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Valpromide Valrocemide Cat. No.: HY-B2117 (TV1901) Cat. No.: HY-100379

Bioactivity: is an amide derivative of valproic acid and Bioactivity: Valrocemide (TV1901) is a promising antiepileptic drug inhibits human epoxide hydrolase. candidate that shows a broad spectrum of anticonvulsant activity.

Purity: 98.0% Purity: 98.01% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Vanilpyruvic acid (Vanylpyruvic acid) Cat. No.: HY-101416 (GBR 12909; I893) Cat. No.: HY-13217A

Bioactivity: Vanilpyruvic acid is a catecholamine metabolite and precursor Bioactivity: Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine to vanillactic acid. reuptake inhibitor).

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg

Vanoxerine dihydrochloride (GBR-12909 dihydrochloride; I893 dihydrochloride) Cat. No.: HY-13217 (CP 526555) Cat. No.: HY-10019

Bioactivity: Vanoxerine 2 Hcl(GBR12909) is a potent and selective DRI Bioactivity: Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic (Dopamine reuptake inhibitor). IC50 value: Target: Dopamine receptor partial agonist; it stimulates nicotine receptors reuptake inhibitor At a cellular level, vanoxerine acts to more weakly than nicotine itself does. IC50 value: Target: block cardiac ion channels. Vanoxerine is a multichannel nAChR Varenicline(CP 526555; Champix; Chantix) is a blocker, acting on IKr (potassium), L-type calcium and sodium… prescription medication used to treat smoking addiction. As a… Purity: 99.64% Purity: 99.98% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Varenicline Hydrochloride Varenicline Tartrate (CP 526555 hydrochloride) Cat. No.: HY-10020 (CP 526555-18) Cat. No.: HY-10021

Bioactivity: Varenicline Hcl(CP 526555;Champix) is a nicotinic receptor Bioactivity: Varenicline Tartrate(CP 526555;Champix) is a nicotinic partial agonist; it stimulates nicotine receptors more weakly receptor partial agonist; it stimulates nicotine receptors than nicotine itself does. IC50 value: Target: nAChR more weakly than nicotine itself does. IC50 value: Target: Varenicline(CP 526555; Champix; Chantix) is a prescription α4β2 nAChR Varenicline(CP 526555; Champix; Chantix) is a medication used to treat smoking addiction. As a partial… prescription medication used to treat smoking addiction. As a… Purity: >98% Purity: 99.90% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Vatinoxan hydrochloride (MK-467 hydrochloride; L-659066 hydrochloride) Cat. No.: HY-19057A Cat. No.: HY-B0118A

Bioactivity: Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 Bioactivity: Vecuronium bromide is a nondepolarizing neuromuscular blocking hydrochloride) is a peripheral α2 adrenergic receptor agent of intermediate duration. antagonist.

Purity: 99.25% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg 10 mg, 50 mg, 100 mg

150 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Venlafaxine hydrochloride (Wy 45030) Cat. No.: HY-B0196 (Wy 45030 hydrochloride) Cat. No.: HY-B0196A

Bioactivity: Venlafaxine is an antidepressant of the Bioactivity: Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. serotonin-norepinephrine reuptake inhibitor (SNRI) class.

Purity: >98% Purity: 99.75% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in Water, 10 mg, 50 mg

VER-155008 Cat. No.: HY-10941 ((±)-Veralipride; LIR166) Cat. No.: HY-101797

Bioactivity: VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, Bioactivity: Veralipride is a D2 receptor antagonist. It is an alternative 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, antidopaminergic treatment for menopausal symptoms.

and with a Kd of 0.3 μM for Hsp70.

Purity: 99.64% Purity: 99.12% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Verbascoside Verilopam (Acteoside; Kusaginin; TJC160) Cat. No.: HY-N0021 Cat. No.: HY-U00338

Bioactivity: Verbascoside is isolated from Lantana camara, acts as an Bioactivity: Verilopam is a potent analgesic.

ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

Purity: 95.67% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

Verubecestat (MK-8931) Cat. No.: HY-16759 (GSK561679) Cat. No.: HY-14875

Bioactivity: (MK-8931) is a beta-secretase 1 (BACE1) Bioactivity: Verucerfont is a corticotropin-releasing factor receptor 1 (

inhibitor under investigation for the treatment of Alzheimer's CRF1) antagonist with IC50s of ~6.1, >1000 and >1000nM Disease. for CRF1, CRF2, and CRF-BP, respectively.

Purity: 99.79% Purity: 99.94% Clinical Data: Phase 3 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Vigabatrin Hydrochloride (γ-Vinyl-GABA) Cat. No.: HY-15399 (γ-Vinyl-GABA hydrochloride) Cat. No.: HY-B0033

Bioactivity: Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the Bioactivity: Vigabatrin Hcl(γ-Vinyl-GABA; Sabril) is a structural analog of inhibitory neurotransmitter γ-aminobutyric acid (GABA) that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) irreversibly inhibits the catabolism of GABA by GABA that irreversibly inhibits the catabolism of GABA by GABA transaminase. IC50 value: Target: GABA transaminase Clinical transaminase. IC50 value: Target: GABA transaminase Clinical studies have shown that vigabatrin is superior to placebo in… studies have shown that vigabatrin is superior to placebo in… Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

www.MedChemExpress.com 151

Vilazodone Hydrochloride (EMD 68843; SB659746A) Cat. No.: HY-14262 (EMD 68843; SB659746A) Cat. No.: HY-14261

Bioactivity: Vilazodone (EMD 68843; SB 659746A) is a combined serotonin Bioactivity: Vilazodone Hydrochloride is a serotonin transporter (SER) specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial inhibitor and 5-HT1A receptor partial agonist. agonist currently under clinical evaluation for the treatment of major depression.

Purity: 99.91% Purity: 99.94% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg

Vinconate Vinpocetine (Chanodesethylapovinc​amine) Cat. No.: HY-U00316 (Ethyl apovincaminate) Cat. No.: HY-13295

Bioactivity: Vinconate is an indolonaphthyridine derivative and can Bioactivity: Vinpocetine(Cavinton; Ethyl apovincaminate) is a selective for stimulate the muscariic acetylcholine receptor. PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels. IC50 value: Target: PDE1; Na+ channel

Purity: >98% Purity: 99.43% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg

Vipadenant Vofopitant (BIIB-014; CEB-4520) Cat. No.: HY-10857 (GR 205171) Cat. No.: HY-12142

Bioactivity: Vipadenant is an adenosine receptor antagonist, with Kis of Bioactivity: Vofopitant is potent tachykinin NK1 receptor antagonist, with

1.3 nM and 68 nM for A 2A and A 1, respectively. pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK 1 receptor, respectively.

Purity: 98.28% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg, 100 mg

Volinanserin (MDL100907; M 100907) Cat. No.: HY-14940 (Lu AA 21004) Cat. No.: HY-15414

Bioactivity: is a potent and selective antagonist of 5-HT2 Bioactivity: Vortioxetine is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A,

receptor, with a Ki of 0.36 nM, and shows 300-fold 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM,

selectivity for 5-HT 2 receptor over 5-HT 1c, alpha-1 and DA 3.7 nM, 19 nM and 1.6 nM, respectively.

D 2 receptors. Volinanserin has antipsychotic activity. Purity: 99.71% Purity: 98.81% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 50 mg

Vortioxetine hydrobromide Vps34-PIK-III (Lu AA21004 hydrobromide) Cat. No.: HY-15414A Cat. No.: HY-12794

Bioactivity: Vortioxetine hydrobromide is a multimodal serotonergic agent, Bioactivity: Vps34-PIK-III is a potent and selective inhibitor of VPS34

inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and with an IC50 of 18 nM.

SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Purity: 99.54% Purity: 99.06% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

152 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

VU 0357121 VU 0364439 Cat. No.: HY-15393 Cat. No.: HY-15476

Bioactivity: VU0357121 is a novel positive and highly selective allosteric Bioactivity: VU 0364439 is a mGlu4 positive allosteric modulator (PAM), modulator (PAM) of mGlu5R with EC50 of 33 nM. with EC50 of 19.8 nM.

Purity: 99.85% Purity: 98.01% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg

VU0152100 VU0357017 hydrochloride (VU152100) Cat. No.: HY-13340 (CID-25010775) Cat. No.: HY-19752A

Bioactivity: VU0152100 is a potent and selective allosteric potentiator of Bioactivity: VU0357017 hydrochloride is a highly selective M1 agonists that M4 mAChR with an EC50 of 380 ± 93 nM. appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15). IC50 value: 477 ± 172 nM (EC50) [1] Target: M1 in vitro: VU0357017 is a M1-selective agonists that appear to activate M1 through… Purity: 99.94% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

VU0361737 VU0364770 (ML-128) Cat. No.: HY-14418 Cat. No.: HY-100588

Bioactivity: VU 0361737 is a selective positive allosteric modulator (PAM) Bioactivity: VU0364770 is an allosteric of metabotropic glutamate receptor

for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and 4 ( mGlu4) modulator, which exhibits a EC50 of 1.1±0.2 rat receptors, respectively, displays weak activity at mGlu5 μM at human mGlu . and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 4 and mGlu7 receptors. Purity: 99.37% Purity: 99.54% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

VU0463271 VU0467154 Cat. No.: HY-110110 Cat. No.: HY-112209

Bioactivity: VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM. Bioactivity: VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the

response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.

Purity: >98% Purity: 98.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

VU6005649 W-2429 Cat. No.: HY-107982 (NSC294836) Cat. No.: HY-100174

Bioactivity: VU6005649 is a CNS penetrant mGlu7/8 receptor agonist Bioactivity: W-2429 is a non-narcotic analgesic agent.

with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and

mGlu8 receptor, respectively.

Purity: 98.91% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 153

WAY-100635 WAY-100635 Maleate Cat. No.: HY-10349 Cat. No.: HY-10349A

Bioactivity: WAY-100635 is a potent and selective 5-HT 1A Receptor Bioactivity: WAY-100635 Maleate is a potent and selective 5-HT 1A Receptor

antagonist with a pIC 50 of 8.87, an apparent pA 2 of 9.71. antagonist with a pIC 50 of 8.87, an apparent pA 2 of 9.71.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

WAY-100635 maleate salt WAY-200070 Cat. No.: HY-13105 Cat. No.: HY-101271

Bioactivity: WAY-100635 maleate is a potent and selective Bioactivity: WAY-200070 is a selective estrogen receptor β ( ERRβ) agonist 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 with an IC50 of 2.3 nM. nM for 5-HT.

Purity: 98.52% Purity: 98.80% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Wf-516 WIN 55,212-2 Mesylate Cat. No.: HY-19417A ((R)-(+)-WIN 55212) Cat. No.: HY-13291

Bioactivity: Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist Bioactivity: WIN 55,212-2 Mesylate is a potent aminoalkylindole cannabinoid

of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human for 5-HT1A receptor and 5-HT2A receptor in humans, recombinant CB1 and CB2 receptors, respectively. respectively, and has potent antidepressant activity.

Purity: >98% Purity: 99.01% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

WWL70 oxalate Cat. No.: HY-100337 (LY246708) Cat. No.: HY-13410

Bioactivity: WWL70 is a selective alpha/beta hydrolase domain 6 ( ABHD6) Bioactivity: Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist. inhibitor with an IC50 of 70 nM.

Purity: 98.88% Purity: 98.63% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 50 mg

Xanthotoxol Cat. No.: HY-30152 Cat. No.: HY-W014666

Bioactivity: Xanthotoxol is a biologically active linear furocoumarin, Bioactivity: Xanthurenic acid is a putative endogenous Group II shows strong pharmacological activities as anti-inflammatory, metabotropic glutamate receptor agonist, on sensory antioxidant, 5-HT antagonistic, and neuroprotective effects. transmission in the thalamus.

Purity: 99.15% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg

154 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

XEN907 Xenin Cat. No.: HY-19958 Cat. No.: HY-P0259

Bioactivity: XEN907 is a novel spirooxindole NaV1.7 blocker, inhibits Bioactivity: Xenin is a 25-amino acid peptide initially isolated from human hNaV1.7 with IC50 of 3 nM. gastric mucosa. Xenin is a gut hormone that can reduce food intake. Sequence: Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg- Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg

Xylazine hydrochloride (BAY 1470) Cat. No.: HY-B0443 (BAY 1470 hydrochloride) Cat. No.: HY-B0443A

Bioactivity: Xylazine is α2 class of adrenergic receptor agonist. Bioactivity: Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.

Purity: >98% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 100 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Y1 receptor antagonist 1 YL0919 Cat. No.: HY-101704 Cat. No.: HY-100769

Bioactivity: Y1 receptor antagonist 1, an isomer of H-409/22, is a Bioactivity: YL0919, a novel antidepressant candidate with dual activity as neuropeptide Y1 receptor antagonist. a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.78±0.34 nM and 1.93±0.18 nM… Purity: >98% Purity: 99.84% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Yohimbine Z-321 Cat. No.: HY-12715 Cat. No.: HY-19123

Bioactivity: Yohimbine is a potent and relatively nonselective alpha Bioactivity: Z-321 is a prolylendopeptidase ( PEP) inhibitor. 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.

Purity: >98% Purity: >98% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 1 g Size: 1 mg, 5 mg, 10 mg

Zatosetron maleate ZD7288 (LY 277359 maleate) Cat. No.: HY-U00234 (ICI D7288) Cat. No.: HY-101346

Bioactivity: maleate is a potent and selective 5HT3 receptor Bioactivity: ZD7288 is a selective hyperpolarization-activated cyclic antagonist. nucleotide-gated ( HCN) channel blocker.

Purity: >98% Purity: 99.79% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

www.MedChemExpress.com 155

Ziprasidone hydrochloride (CP-88059) Cat. No.: HY-14542 (CP-88059 hydrochloride) Cat. No.: HY-14542A

Bioactivity: Ziprasidone(CP88059) is a combined 5-HT (serotonin) and Bioactivity: Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin) dopamine receptor antagonist which exhibits potent effects of and dopamine receptor antagonist which exhibits potent effects antipsychotic activity. of antipsychotic activity.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10 mg, 50 mg

Ziprasidone hydrochloride monohydrate ZK200775 (CP 88059) Cat. No.: HY-17407 (; MPQX) Cat. No.: HY-15069

Bioactivity: Ziprasidone(CP88059) is a combined 5-HT (serotonin) and Bioactivity: ZK200775(Fanapanel; MPQX) is a highly selective AMPA/kainate dopamine receptor antagonist which exhibits potent effects of antagonist with little activity against NMDA; have Ki values antipsychotic activity. of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.

Purity: 98.29% Purity: 99.93% Clinical Data: Launched Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg, 50 mg

ZK200775 hydrate ZL006 (Fanapanel hydrate; MPQX hydrate) Cat. No.: HY-15069A Cat. No.: HY-100456

Bioactivity: ZK200775 hydrate(Fanapanel; MPQX) is a highly selective Bioactivity: ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and AMPA/kainate antagonist with little activity against NMDA; inhibits NMDA receptor-mediated NO synthesis. have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.

Purity: 98.98% Purity: 99.81% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ZM241385 ZM39923 Cat. No.: HY-19532 Cat. No.: HY-12589A

Bioactivity: ZM 241385 is a novel non- adenosine receptor Bioactivity: ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 antagonist with selectivity for the A2a receptor subtype. also potently inhibits tissue transglutaminase ( TGM2) with

an IC50 of 10 nM.

Purity: 98.55% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

ZM39923 hydrochloride Zofenopril Cat. No.: HY-12589 Cat. No.: HY-108321

Bioactivity: ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of Bioactivity: Zofenopril is an angiotensin-converting enzyme ( ACE) inhibitor with an IC of 81 μM. 7.1; ZM39923 hydrochloride also potently inhibits tissue 50

transglutaminase ( TGM2) with an IC50 of 10 nM.

Purity: 98.0% Purity: 98.81% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 5 mg 10 mg, 50 mg

156 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Zonisamide sodium (AD 810; CI 912) Cat. No.: HY-B0124 (AD 810 sodium; CI 912 sodium) Cat. No.: HY-B0124A

Bioactivity: Zonisamide is a 1,2 derivative and the first Bioactivity: Zonisamide sodium is a 1,2 benzisoxazole derivative and the agent of this chemical class to be developed as an first agent of this chemical class to be developed as an antiepileptic drug. antiepileptic drug.

Purity: 99.72% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 200 mg, 500 mg 200 mg, 500 mg

Zoxazolamine ZSET-845 Cat. No.: HY-B1307 Cat. No.: HY-U00114

Bioactivity: Zoxazolamine is widely used for a pharmacologic test that Bioactivity: ZSET-845 is a cognitive enhancer which enhances choline serves as a convenient indicator of changes in cytochrome acetyltransferase activity in the in the rat. P-450 activity in rodents.

Purity: 98.13% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 50 mg

ZSET1446 ZT 52656A hydrochloride (ST-101) Cat. No.: HY-11013 Cat. No.: HY-101582

Bioactivity: ZSET1446 is a novel cognitive enhancer that significantly Bioactivity: ZT 52656A is a selective kappa opioid agonist, used for the improves learning deficits in various types of Alzheimer prevention or alleviation of pain in the eye. disease (AD) models.

Purity: 98.03% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Zuclopenthixol [Arg8]- ((Z)-) Cat. No.: HY-A0163 Cat. No.: HY-P1574

Bioactivity: is a thioxanthene derivative which acts as a Bioactivity: [Arg8]-Vasotocin is a vertebrate neurohypophyseal peptide of mixed dopamine D1/D2 receptor antagonist. the vasopressin/oxytocin hormone family.

Purity: 98.80% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 50 mg

[Leu5]-Enkephalin [Leu5]-Enkephalin, amide (Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin) Cat. No.: HY-P0288 (Leu-Enkephalin amide) Cat. No.: HY-P1470

Bioactivity: [Leu5]-Enkephalin is a pentapeptides with like Bioactivity: [Leu5]-Enkephalin, amide is a δ opioid receptor agonist. properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors. Sequence: Tyr-Gly-Gly-Phe-Leu.

Purity: 99.72% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 25 mg 10 mg, 25 mg

www.MedChemExpress.com 157

[Met5]-Enkephalin, amide [Nle11]-Substance P (5-Methionine-enkephalin amide) Cat. No.: HY-P1467 Cat. No.: HY-P1506

Bioactivity: [Met5]-Enkephalin, amide is an agonist for δ opioid Bioactivity: [Nle11]-Substance P is a substance P analog that avoids receptors as well as putative ζ ζ opioid receptors. methionine oxidation problems.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg

[Sar9,Met(O2)11]-Substance P α1 adrenoceptor-MO-1 Cat. No.: HY-P1012 Cat. No.: HY-U00333

Bioactivity: [Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor Bioactivity: α1 adrenoceptor-MO-1, an S enantiomer, has affinity at alpha 1 selective agonist. Sequence: adrenergic receptor, shows alphalytic activity, and possesses Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-Met[O2]-NH2. analgesic action; more active than R enantiomer.

Purity: 98.45% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

β-Amino Acid Imagabalin Hydrochloride β-Amyloid (1-42), rat (PD-0332334) Cat. No.: HY-U00250 (Amyloid β-peptide (1-42) (rat)) Cat. No.: HY-P1388

Bioactivity: β-Amino Acid Imagabalin Hydrochloride (PD-0332334) is a ligand Bioactivity: β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic for the α2δ subunit of the voltage-dependent calcium effect on acute hippocampal slices, and used in the research channel. of Alzheimer's disease.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 500u g, 1 mg, 5 mg

β-Amyloid (1-42), rat TFA β-Amyloid (10-35), amide Cat. No.: HY-P1388A Cat. No.: HY-P1567

Bioactivity: β-Amyloid (1-42), rat TFA is a 42-aa peptide, shows cytotoxic Bioactivity: β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues effect on acute hippocampal slices, and used in the research of the Aβ peptide) and is the primary component of the amyloid of Alzheimer's disease. plaques of Alzheimer’s disease.

Purity: 95.17% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg

β-amyloid 1-11 β-Amyloid 1-15 Cat. No.: HY-P1510 (Amyloid β-Protein (1-15)) Cat. No.: HY-P1046

Bioactivity: β-amyloid (1-11) is a fragment of Amyloid-β peptide, maybe Bioactivity: β-Amyloid (1-15) is a fragment of β-Amyloid peptide. used in the research of neurological disease. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

158 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

β-Amyloid 1-16 β-Amyloid 1-28 (Amyloid β-Protein (1-16)) Cat. No.: HY-P1466 (Amyloid β-Protein (1-28)) Cat. No.: HY-P1468

Bioactivity: β-Amyloid (1-16) is a β-Amyloid protein fragment involved in Bioactivity: β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients. plaques in the brains of Alzheimer's disease (AD) patients.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

β-Amyloid 1-40 β-amyloid 12-28 Cat. No.: HY-P0265 (Amyloid β-Protein (12-28)) Cat. No.: HY-P1051

Bioactivity: β-Amyloid (1-40) is a primary protein in plaques found in the Bioactivity: β-amyloid (12-28) is a 17-aa peptide fragment, which can brains of patients with Alzheimer's disease. Sequence: Asp-Ala produce amyloid aggregates, used in the research of -Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-V Alzheimer’sdisease. al-Phe-Phe-Ala-Glu-Asp Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gl y-Leu-Met-Val-Gly-Gly-Val-Val. Purity: 95.09% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg

β-Amyloid 15-21 β-Amyloid 22-35 (Beta-Amyloid (15-21)) Cat. No.: HY-P1521 (Amyloid β-Protein (22-35)) Cat. No.: HY-P1474

Bioactivity: β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe Bioactivity: β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and used in the research of neurological disease. induces in the hippocampal cells.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

β-Amyloid 29-40 β-Amyloid 31-35 (Amyloid beta-protein(29-40)) Cat. No.: HY-P1522 Cat. No.: HY-P1517

Bioactivity: β-Amyloid (29-40) is a fragment of Amyloid-β peptide. Bioactivity: β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

β- ((−)-trans-Caryophyllene; β-, bovine (−)-β-caryophyllene; (-)-(E)-Caryophyllene) Cat. No.: HY-N1415 (β-Casomorphin-7 (bovine); Bovine β-casomorphin-7) Cat. No.: HY-P0179

Bioactivity: β-Caryophyllene is a CB2 receptor agonist. Bioactivity: β-casomorphin, bovine (β-casomorphin-7) is a opioid peptide

with an IC50 of 14 μM in an Opioid receptors binding assay.

Purity: 94.40% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 500 mg

www.MedChemExpress.com 159

β-Endorphin, human β-Glycerol phosphate disodium salt pentahydrate Cat. No.: HY-P1502 (β-Glycerophosphate disodium salt pentahydrate) Cat. No.: HY-D0886

Bioactivity: β-Endorphin, human, a prominent endogenous peptide, existing Bioactivity: β-Glycerol phosphate disodium salt pentahydrate is a in the hypophysis cerebri and hypothalamus, is an agonist of Phosphatase and tensin homolog ( PTEN) inhibitor opioid receptor, with preferred affinity for μ-opioid receptor extracted from patent US 20110002877 A1. and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity. Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 g, 5 g 1 mg, 5 mg, 10 mg

β-Melanocyte Stimulating Hormone (MSH), human β-Secretase Inhibitor IV (Beta-MSH (1-22) (human)) Cat. No.: HY-P1504 (Axon 1125) Cat. No.: HY-10133

Bioactivity: β-Melanocyte Stimulating Hormone (MSH), human is a Bioactivity: β-Secretase Inhibitor IV is a potent, cell-active BACE-1 melanocortin (MC) receptor agonist. inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 250 mg, 500 mg

δ-Sleep Inducing Peptide (Delta-Sleep Inducing Peptide) Cat. No.: HY-P1501

Bioactivity: δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.

Purity: >98% Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg

160 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]