DOCSLIB.ORG

19Th Biennial IPEG Meeting Nijmegen, the Netherlands

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
19Th Biennial IPEG Meeting Nijmegen, the Netherlands Neuropsychiatric Electrophysiology 2016, 2(Suppl 1):8 DOI 10.1186/s40810-016-0021-4 MEETINGABSTRACTS Open Access 19th biennial IPEG Meeting Nijmegen, The Netherlands. 26-30 October 2016 Published: 29 November 2016 Training course measures. This will be illustrated by means of pertinent examples. These include elucidating the mechanisms of stimulant action re- A1 mediating deficient impulse control and the role of the cannabinoid Thalamocortical sleep oscillations system in human working memory, as well as drug effects on Igor Timofeev1,2 sensory gating and specific aspects of visual-spatial attention. Other 1Department of Psychiatry and Neuroscience, Université Laval, Québec, examples concern the added sensitivity of EEG and ERP measures, Canada; 2Centre de recherche de l’Institut universitaire en santé mentale relative to that of performance measures, in detecting effects of alco- de Québec (CRIUSMQ), Université Laval, Québec, Canada hol, and more generally in monitoring and predicting vigilance and Neuropsychiatric Electrophysiology 2016, 2(Suppl 1):A1 the ability to detect external signals in the immediate future. Rela- tions between brain signals and cognitive competences are revealed In waking and sleeping states, thalamocortical system generates a by either comparing different individuals, or moment-to-moment variety of oscillations ranging from 0.1 Hz to hundreds of Hz. Most of fluctuations within individuals, or differences in state (e.g., drug- them are present during NREM sleep, but slower activities prevail in induced) within individuals. this state of vigilance. Thalamocortical network is organized in a loop in which thalamocortical cells excite reticular thalamic and neocor- tical cells, reticular thalamic cells inhibit thalamocortical cells and A3 corticothalamic cells excite thalamocortical and reticular thalamic EEG and ERP as key techniques for functional brain alterations cells. Despite stable anatomical connectivity, different types of oscil- studies lations preferentially originate either in neocortex or in thalamus. P. F. Fabene During sleep stage 2, spindle oscillation (9–15 Hz) is a dominant type Department Neuroscience, Biomedicine and Movement, School of of activity. It is well accepted that spindles originate in the thalamus Medicine, University of Verona, Verona, Italy via interplay of firing of reticular thalamic and thalamocortical Neuropsychiatric Electrophysiology 2016, 2(Suppl 1):A3 neurons, but neocortex controls spindle generation. Spindles can be divided on fast and slow. Several properties of slow spindles do not Behavioral studies in rodents are basically based on inferring cognitive match known mechanisms of their thalamic origin. processes out of locomotor activity. In other words, we evaluate mem- Slow oscillation (about 1 Hz) dominates slow-wave sleep stage. Each ory processes during Morris water maze, or Novel object recognition slow wave is composed of hyperpolarized or silent and depolarized based on the time spent of the given subject in close proximity of an and active state. Active states may be accompanied by spindles and item, platform, or the time required to reach or leave an area of the higher frequency activities. Slow waves originate mainly in deep cage/maze. By the mean of automatic scoring systems (e.g.: Ethovision, cortical layers from which they propagate to more superficial layers AniMaze, etc.) we are provided by objective measurements, which and they also propagate horizontally. Full expression of slow wave should be in any case interpreted by the researcher. There is always a activities requires the presence of thalamus, although slow oscillation lack of direct measurement of the cognitive processes. Integration of can be recorded in athalamic preparations. behavioural scoring with electrical activity evaluation of different areas Therefore, despite the fact of preferential origin of different sleep involved in cognitive processing can be a useful tool, to provide oscillations in either neocortex or in thalamus, only the full thalamo- scientists further parameter helpful in data interpretation. We will thus ’ cortical network can generate sleep activities with known properties. discuss the integration of EEG analysis in Alzheimersmildcognitive Support: CIHR and NSERC. impairment and acoustic ERPs in AD and epilepsy. A4 A2 Targeting EEG network oscillations: translational opportunities for Electropsychopharmacology: applying EEG and ERP to drug discovery science in psychiatric and neurodegenerative psychopharmacology disorders Leon Kenemans A. Ahnaou ([email protected]) Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, Department of Neuroscience Discovery, Janssen Research & Netherlands Development, a Division of Janssen Pharmaceutica NV. Turnhoutseweg Neuropsychiatric Electrophysiology 2016, 2(Suppl 1):A2 30, B-2340 Beerse, Belgium Neuropsychiatric Electrophysiology 2016, 2(Suppl 1):A4 Electroencephalography (EEG), in particular event-related or evoked potentials (ERPs), as well as their magnetic counterparts, can yield Despite decades of research in psychiatric and neurodegenerative useful supplementary information when interpreting effects of psy- disorders, the attrition rate in clinical trials and late-stage drug dis- choactive substances on behavior. They can be used to elucidate the covery programs for the development of novel agents for disease neurocognitive mechanisms that underlie pharmacological modula- interception has been unacceptably high. The major issue facing tion of behavior, or they may provide additional sensitivity to detect neuroscience drug discovery is that drugs that show good effectivity neurocognitive effects that are not readily observable in behavioral in preclinical models often fail to meet clinical trials endpoints. The © The Author(s). 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Neuropsychiatric Electrophysiology 2016, 2(Suppl 1):8 Page 2 of 34 limitations of the traditional animal-based assays prompted a resur- efficacy of stimulant medication, limited efficacy of antidepressant medica- gence of interest in rethinking animal models and their predictability tions and overall limited efficacy of behavioral interventions on the group and translational validity in translational neuroscience. Better transla- level. It hence becomes obvious there is a need for a re-conceptualization tion of a biomarker and endophenotype of the disease might rapidly of psychiatric disorders along the lines of NIMH proposed Research Do- provide information regarding the effects of drugs on the underlying main Criteria (RDoC) or referred to as biomarkers or personalized medicine. disease biology, bridge the translational gap and potentially lower the Personalized Medicine aims to prescribe the right treatment, for the right rate of clinical trial attrition. An increasing number of experimental and person at the right time as opposed to the currently employed ‘one-size- clinical observations suggest that those chronic brain disorders arise fits-all’ approach. This development relies on identification of subgroups from structural alterations in neuronal circuits, and therefore focus has using biomarkers. been shifted towards investigation of electrophysiological correlates of This presentation will summarize the current status of EEG based the molecular pathology, with emphasis on neural oscillations and con- personalized medicine and present new results from large bio- nectivity as promising candidate biomarkers of neuronal disorders. marker studies in depression and ADHD focused on resting-state State-of-the-art examples of pharmacological studies modeling EEG. Several results from the iSPOT study (international Study to abnormal network oscillations and disturbed connectivity of several Predict Optimized Treatment) in Depression and ADHD will be CNS disorders will be discussed. presented [1,2,3,4,5]. In iSPOT-D, 1008 depressed patients are ran- domized to Escitalopram, Sertraline or Venlafaxine and in iSPOT-A 336 ADHD patients are prescribed with methylphenidate and A5 patients were assessed at baseline on resting-state EEG and other Source localization using LORETA software measures. Several promising biomarkers that can predict treat- Sebastian Olbrich ([email protected]) ment response and remission using baseline biomarkers will be Department for Psychiatry, Psychotherapy and Psychosomatic, University presented and the importance of gender differences will be of Zurich, Zurich, Switzerland discussed in more detail. Neuropsychiatric Electrophysiology 2016, 2(Suppl 1):A5 References The training course will be dedicated to the usage of LORETA soft- 1. Arns, M., Bruder, G., Hegerl, U., Spooner, C., Palmer, D. M., Etkin, A., . ware for localization of neuronal sources of EEG activity. After a brief Gordon, E. (2015a). EEG alpha asymmetry as a gender-specific predictor introduction into the underlying physiology and theoretical assump- of outcome to acute treatment with different
Load more

Recommended publications
  • Traditional Medicine and Ethnomedical Research
    International Conference on TRADITIONAL MEDICINE AND ETHNOMEDICAL RESEARCH OCTOBER 24-25, 2019 ToKYO, JAPAN Theme: Healthy Life in Natures Lap Radisson Hotel Narita 286-0221 Chiba Tomisato-shi Nakaei 650-35 Tokyo, Japan @ICTM2019 TraditionalMedicine_EthnoMedicine_2019 ICTM https://traditional-medicine-conferences.magnusgroup.org/ EXHIBITOR 2019 ICTM 2019 BOOK OF ABSTRACTS International Conference on TRADITIONAL MEDICINE AND EtHNOMEDICAL RESEARCH Theme: Healthy Life in Natures Lap October 24-25, 2019 Tokyo, Japan INDEX Contents Pages Welcome Message 8 Keynote Speakers 10 About the Host 11 About Exhibitor 12 Keynote Session (Day 1) 13 Speaker Session (Day 1) 19 Keynote Session (Day 2) 37 Speaker Session ( Day 2) 43 Poster Presentations 66 Attendees Mailing List 74 ICTM 2019 Abuzar Ansari Amrita Sharma Annette Booiman Arturo Huerta-López Baohong Jiang Ewha Womens University Amrita’s Ayuryogavidya, a Mensendieckmoves, Comunidad Biocultural, A.C., Shanghai Institute of Materia Mokdong Hospital, Korea centre of excellence for well- Netherlands México Medica, China ness and holistic health, India Barend van Heerden Bernd-Michael Löffler Chanin Sillapachaiyaporn Charles Shang Chen Che-Yi Indian Board of Alternative Institute for Mitochondrial Chulalongkorn University, University Of Texas MD Ander- Taipei Medical University, Medicine, South Africa Medicine, Germany Thailand son Cancer Center, USA Taiwan Chihiro Sugita Dominique de Rocca Serra Fai Chan Fossion Jean G. R. Padmasiri Kyushu University of Health University of Corsica Deli Aroma LLC Group Investigation of dys-Au- University of the Visual and and Welfare, Japan France USA tonomy (GidA), Belgium Performing Arts, Sri Lanka Geoffrey W Abbott Hiroyoshi Tahata Irmgard Rose Parys James Teng Jia-Ming Chen University of California, Japanese Rolfing Association, Community Practice Dres.
    [Show full text]
  • 42711 IPEG Programmaboekje
    19 th Biennial Conference 19th Biennial Conference October 26th – 30th 2016 October 26 Nijmegen, the Netherlands th – 30 th 2016 Nijmegen, the Netherlands 2016 Nijmegen, 42711 IPEG programmaboekje omslag.indd 1 06-10-16 17:52 The “International Pharmaco-EEG Society, Association for Electrophysiological Brain Research in Preclinical and Clinical Pharmacology and Related Fields” (IPEG) is a non-profit organization, established in 1980 and composed of scientists and researchers actively involved in electrophysiological brain research in preclinical and clinical pharmacology, neurotoxicology and related areas of interest. my.thesis nl for the design of your Thesis & to show your Thesis 42711 IPEG programmaboekje omslag.indd 2 06-10-16 17:52 IPEG 2016 in Nijmegen | 1 Welcome to Nijmegen, dear attendants of the 19th IPEG meeting. Nijmegen, a 2000 year old city; Nijmegen, a Roman and a medieval city; Nijmegen, the home town of the first catholic university funded by the Faithfull to improve education of a suppressed part of the Netherlands; Nijmegen, the city that heavily suffered in WWII; Nijmegen, the home town of the Donders Institute. Nijmegen, as we hope and trust, your home town for the upcoming IPEG meeting. As you all know, electrophysiological brain research has a long tradition going back as far as 1875 when the first report on the animal electroencephalogram (EEG) was published by Caton. The often forgotten Polish physiologist Adolf Beck was also a EEG pioneer many years before Hans Berger’s initial reports. Beck recorded electrical potentials in several brain areas evoked by peripheral sensory stimuli. Using this technique, Beck localised various centres in the brain of several animal species and described desynchronization in electrical brain potentials.
    [Show full text]
  • Functional Connectivity Changes in Cerebral Small
    Schulz et al. BMC Medicine (2021) 19:103 https://doi.org/10.1186/s12916-021-01962-1 RESEARCH ARTICLE Open Access Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature Maximilian Schulz1, Caroline Malherbe1,2, Bastian Cheng1, Götz Thomalla1 and Eckhard Schlemm1* Abstract Background: Cerebral small vessel disease (CSVD) is a common neurological disease present in the ageing population that is associated with an increased risk of dementia and stroke. Damage to white matter tracts compromises the substrate for interneuronal connectivity. Analysing resting-state functional magnetic resonance imaging (fMRI) can reveal dysfunctional patterns of brain connectivity and contribute to explaining the pathophysiology of clinical phenotypes in CSVD. Materials and methods: This systematic review provides an overview of methods and results of recent resting- state functional MRI studies in patients with CSVD. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol, a systematic search of the literature was performed. Results: Of 493 studies that were screened, 44 reports were identified that investigated resting-state fMRI connectivity in the context of cerebral small vessel disease. The risk of bias and heterogeneity of results were moderate to high. Patterns associated with CSVD included disturbed connectivity within and between intrinsic brain networks, in particular the default mode, dorsal attention, frontoparietal control, and salience networks; decoupling of neuronal activity along an anterior–posterior axis; and increases in functional connectivity in the early stage of the disease. Conclusion: The recent literature provides further evidence for a functional disconnection model of cognitive impairment in CSVD.
    [Show full text]
  • Rehabilitation of Executive Dysfunction in Multiple Sclerosis: Cognitive, Behavioural and Neurophysiological Effects of Goal Management Training
    Rehabilitation of Executive Dysfunction in Multiple Sclerosis: Cognitive, Behavioural and Neurophysiological Effects of Goal Management Training by Nadine Marie Richard A thesis submitted in conformity with the requirements for the degree of Doctor of Philosophy Department of Psychology University of Toronto © Copyright by Nadine Marie Richard 2013 Rehabilitation of Executive Dysfunction in Multiple Sclerosis: Cognitive, Behavioural and Neurophysiological Effects of Goal Management Training Nadine Marie Richard Doctor of Philosophy Department of Psychology University of Toronto 2013 Abstract Multiple sclerosis (MS) is a chronic, progressive central nervous system disease characterized by distributed white matter injury. Particularly prevalent in Canada, MS is a leading cause of disability with extended personal and societal costs given its early onset (on average between 20- 40 years of age). Deficits in executive functioning are common and detrimental to employment, daily functioning and quality of life, however their precise nature remains underspecified. Two studies were undertaken to: (1) describe the executive processes affected in MS, including neurophysiological correlates, and (2) explore, in a double-blind randomized controlled trial, patients’ response to an intervention for improving behavioural self-regulation. Study 1 described significant functional limitations and impairments in processing speed and executive control of attention, memory and working memory in MS patients, both relative to neurologically healthy controls and as a monotonic function of disease severity. Mean amplitudes for event- related potentials (ERPs) including the P3 and the error-related negativity and positivity (ERN, Pe) were linked to behavioural markers of attention control and performance monitoring. ERP amplitudes and ERP-behavioural associations appeared sensitive to the presence and severity of executive dysfunction related to disease progression.
    [Show full text]
  • Classification Decisions Taken by the Harmonized System Committee from the 47Th to 60Th Sessions (2011
    CLASSIFICATION DECISIONS TAKEN BY THE HARMONIZED SYSTEM COMMITTEE FROM THE 47TH TO 60TH SESSIONS (2011 - 2018) WORLD CUSTOMS ORGANIZATION Rue du Marché 30 B-1210 Brussels Belgium November 2011 Copyright © 2011 World Customs Organization. All rights reserved. Requests and inquiries concerning translation, reproduction and adaptation rights should be addressed to [email protected]. D/2011/0448/25 The following list contains the classification decisions (other than those subject to a reservation) taken by the Harmonized System Committee ( 47th Session – March 2011) on specific products, together with their related Harmonized System code numbers and, in certain cases, the classification rationale. Advice Parties seeking to import or export merchandise covered by a decision are advised to verify the implementation of the decision by the importing or exporting country, as the case may be. HS codes Classification No Product description Classification considered rationale 1. Preparation, in the form of a powder, consisting of 92 % sugar, 6 % 2106.90 GRIs 1 and 6 black currant powder, anticaking agent, citric acid and black currant flavouring, put up for retail sale in 32-gram sachets, intended to be consumed as a beverage after mixing with hot water. 2. Vanutide cridificar (INN List 100). 3002.20 3. Certain INN products. Chapters 28, 29 (See “INN List 101” at the end of this publication.) and 30 4. Certain INN products. Chapters 13, 29 (See “INN List 102” at the end of this publication.) and 30 5. Certain INN products. Chapters 28, 29, (See “INN List 103” at the end of this publication.) 30, 35 and 39 6. Re-classification of INN products.
    [Show full text]
  • Enhanced Dendritic Inhibition and Impaired NMDAR Activation in a Mouse Model of Down Syndrome
    This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Articles: Neurobiology of Disease Enhanced dendritic inhibition and impaired NMDAR activation in a mouse model of Down syndrome Jan M. Schulz1, Frederic Knoflach2, Maria-Clemencia Hernandez2 and Josef Bischofberger1 1Department of Biomedicine, University of Basel, Pestalozzistr. 20, CH-4056 Basel, Switzerland 2Pharma Research and Early Development, Discovery Neuroscience Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland https://doi.org/10.1523/JNEUROSCI.2723-18.2019 Received: 22 October 2018 Revised: 9 April 2019 Accepted: 10 April 2019 Published: 18 April 2019 Author contributions: J.M.S., M.C.H., and J.B. designed research; J.M.S. and F.K. performed research; J.M.S. analyzed data; J.M.S. and J.B. wrote the first draft of the paper; J.M.S. and J.B. wrote the paper; F.K., M.C.H., and J.B. edited the paper. Conflict of Interest: The authors declare no competing financial interests. We would like to thank Tom Otis for helpful comments on the manuscript. We thank Selma Becherer and Martine Schwager for mouse genotyping, histochemical stainings and technical assistance, Marie-Claire Pflimlin for some electrophysiological recordings and Andrew Thomas for RO4938581 supply. This work was supported by a Roche Postdoctoral Fellowship and by the Swiss National Science Foundation (SNSF, Project 31003A_176321). The authors declare no competing financial interests. Correspondence: Dr. Josef Bischofberger, Department of Biomedicine, University of Basel, Pestalozzistr. 20, CH-4046 Basel, Switzerland, Phone: +41-61-2672729, E-mail: [email protected] Cite as: J.
    [Show full text]
  • PAMPER YOURSELF FESTIVE RECIPES STAY SHARP Truth
    HEALTHY LIVING HEALTHY PLANET feel good • live simply • laugh more FREE Take One/Share One PAMPER YOURSELF ime ays to ene ody ind and irit ey roga on the Trut out epressio hy eds ont or and hat oes STAY oerf ays to Avoid enta ecine FESTIVE RECIPES so Vegan oiday reats POWERFUL that veryone oves PILATES November 2016 | San Antonio Area | NaturalAwakeningsSA.com Look No Further... Here is the Business Opportunity You’ve Been Looking For San Antonio Natural Awakenings Magazine is FOR SALE • The Nation’s Leading Healthy/Green Lifestyle Magazine • 20 Years of Publishing Experience • Monthly National Readership of Over 3.8 Million • Exceptional Franchise Support & Training • Make a Difference in Your Community • Proven Business System • Home-Based Operation Call today for more information! Natural Awakenings recently won the prestigious FBR50 Franchise Satisfaction Award. Our publishers ranked us 239-530-1377 or visit among the highest in franchise satisfaction for our Training, 2 NaturalAwakeningsSanAntonio NaturalAwakeningsMag.com/mymagazine Support, Core Values and Integrity! Look No Further... Here is the Business Opportunity You’ve Been Looking For San Antonio Natural Awakenings Magazine is FOR SALE • The Nation’s Leading Healthy/Green Lifestyle Magazine • 20 Years of Publishing Experience • Monthly National Readership of Over 3.8 Million • Exceptional Franchise Support & Training • Make a Difference in Your Community • Proven Business System • Home-Based Operation Call today for more information! Natural Awakenings recently won the prestigious FBR50 Franchise Satisfaction Award. Our publishers ranked us 239-530-1377 or visit among the highest in franchise satisfaction for our Training, NaturalAwakeningsMag.com/mymagazine Support, CoreNaturalAwakeningsSA.com Values and Integrity! November 2016 3 contents Natural Awakenings is your monthly guide to a healthier, more balanced life.
    [Show full text]
  • Nocturnal Enuresis Or Bedwetting
    CASE STUDY Improvement in a 6 year-old Child with Autistic Spectrum Disorder and Nocturnal Enuresis under Upper Cervical Chiropractic Care Allison Noriega, DC,1 Jonathan Chung, DC,2 Justin Brown, DC2 ABSTRACT Objectives: To report on the improvement of a pediatric patient with nocturnal enuresis and Autistic Syndrome Disorder (ASD), after undergoing upper cervical specific chiropractic care. Clinical Features: A 6 year-old oy who presented for chiropractic care with a history of nocturnal enuresis and ASD. The child experienced a traumatic irth and at the time of chiropractic care was following the Defeat Autism Now# (DAN#) Protocol. Intervention and Outcomes: An atlas su luxation complex was determined ased on clinical data collected at the first visit. O jective clinical evaluation included: static palpation, motion palpation, radiographs, paraspinal thermography, supine leg length ine(uality, as well as measurements of hip leveling, and ilateral weight distri ution. National )pper Cervical Chiropractic Association (N)CCA) upper cervical specific adjustments were administered over a 1,-wee- period. There was an overall reduction in the patient.s pattern of atlas su luxation, in addition to successful resolution of nocturnal enuresis and mar-ed improvement in oth his social interactions and learning difficulties at school. Conclusions: The case presentation of a 6 year-old oy with nocturnal enuresis and Autistic Spectrum Disorder who underwent upper cervical chiropractic care is descri ed. The reduction of verte ral su luxation was related
    [Show full text]
  • Patent Application Publication ( 10 ) Pub . No . : US 2019 / 0192440 A1
    US 20190192440A1 (19 ) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0192440 A1 LI (43 ) Pub . Date : Jun . 27 , 2019 ( 54 ) ORAL DRUG DOSAGE FORM COMPRISING Publication Classification DRUG IN THE FORM OF NANOPARTICLES (51 ) Int . CI. A61K 9 / 20 (2006 .01 ) ( 71 ) Applicant: Triastek , Inc. , Nanjing ( CN ) A61K 9 /00 ( 2006 . 01) A61K 31/ 192 ( 2006 .01 ) (72 ) Inventor : Xiaoling LI , Dublin , CA (US ) A61K 9 / 24 ( 2006 .01 ) ( 52 ) U . S . CI. ( 21 ) Appl. No. : 16 /289 ,499 CPC . .. .. A61K 9 /2031 (2013 . 01 ) ; A61K 9 /0065 ( 22 ) Filed : Feb . 28 , 2019 (2013 .01 ) ; A61K 9 / 209 ( 2013 .01 ) ; A61K 9 /2027 ( 2013 .01 ) ; A61K 31/ 192 ( 2013. 01 ) ; Related U . S . Application Data A61K 9 /2072 ( 2013 .01 ) (63 ) Continuation of application No. 16 /028 ,305 , filed on Jul. 5 , 2018 , now Pat . No . 10 , 258 ,575 , which is a (57 ) ABSTRACT continuation of application No . 15 / 173 ,596 , filed on The present disclosure provides a stable solid pharmaceuti Jun . 3 , 2016 . cal dosage form for oral administration . The dosage form (60 ) Provisional application No . 62 /313 ,092 , filed on Mar. includes a substrate that forms at least one compartment and 24 , 2016 , provisional application No . 62 / 296 , 087 , a drug content loaded into the compartment. The dosage filed on Feb . 17 , 2016 , provisional application No . form is so designed that the active pharmaceutical ingredient 62 / 170, 645 , filed on Jun . 3 , 2015 . of the drug content is released in a controlled manner. Patent Application Publication Jun . 27 , 2019 Sheet 1 of 20 US 2019 /0192440 A1 FIG .
    [Show full text]
  • Détection Automatisée Des Hallucinations Auditives En IRM Fonctionnelle Et Perspectives Thérapeutiques Dans La Schizophrénie Thomas Fovet
    Détection automatisée des hallucinations auditives en IRM fonctionnelle et perspectives thérapeutiques dans la schizophrénie Thomas Fovet To cite this version: Thomas Fovet. Détection automatisée des hallucinations auditives en IRM fonctionnelle et perspec- tives thérapeutiques dans la schizophrénie. Médecine humaine et pathologie. Université du Droit et de la Santé - Lille II, 2017. Français. NNT : 2017LIL2S036. tel-01956591v2 HAL Id: tel-01956591 https://tel.archives-ouvertes.fr/tel-01956591v2 Submitted on 11 Jan 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. ÉCOLE DOCTORALE BIOLOGIE ET SANTÉ UNIVERSITÉ DE LILLE Thèse d’Université DÉTECTION AUTOMATISÉE DES HALLUCINATIONS AUDITIVES EN IRM FONCTIONNELLE ET PERSPECTIVES THÉRAPEUTIQUES DANS LA SCHIZOPHRÉNIE Auteur Directeur Thomas FOVET Pr. Renaud JARDRI THÈSE SOUTENUE LE 15 DECEMBRE 2017 POUR L’OBTENTION DU GRADE DE DOCTEUR DE L’UNIVERSITÉ DE LILLE DISCIPLINE : NEUROSCIENCES JURY Pr. Arnaud CACHIA, Université Sorbonne-Paris-Cité - Rapporteur Dr. Emilie OLIE, CHU & Université de Montpellier - Rapporteur Dr. Ingrid DE CHAZERON, CHU de Clermont-Ferrand - Assesseur Pr. Pierre THOMAS, Université & CHU de Lille - Assesseur Dr. Delphine PINS, CNRS & Université de Lille - Assesseur Pr. Renaud JARDRI, Université & CHU de Lille - Directeur de Thèse “There are two kinds of truth: the truth that lights the way and the truth that warms the heart.
    [Show full text]
  • Lääkeaineiden Yleisnimet (INN-Nimet) 21.6.2021
    Lääkealan turvallisuus- ja kehittämiskeskus Säkerhets- och utvecklingscentret för läkemedelsområdet Finnish Medicines Agency Lääkeaineiden yleisnimet (INN-nimet) 21.6.
    [Show full text]
  • World of Cognitive Enhancers
    ORIGINAL RESEARCH published: 11 September 2020 doi: 10.3389/fpsyt.2020.546796 The Psychonauts’ World of Cognitive Enhancers Flavia Napoletano 1,2, Fabrizio Schifano 2*, John Martin Corkery 2, Amira Guirguis 2,3, Davide Arillotta 2,4, Caroline Zangani 2,5 and Alessandro Vento 6,7,8 1 Department of Mental Health, Homerton University Hospital, East London Foundation Trust, London, United Kingdom, 2 Psychopharmacology, Drug Misuse, and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, 3 Swansea University Medical School, Institute of Life Sciences 2, Swansea University, Swansea, United Kingdom, 4 Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy, 5 Department of Health Sciences, University of Milan, Milan, Italy, 6 Department of Mental Health, Addictions’ Observatory (ODDPSS), Rome, Italy, 7 Department of Mental Health, Guglielmo Marconi” University, Rome, Italy, 8 Department of Mental Health, ASL Roma 2, Rome, Italy Background: There is growing availability of novel psychoactive substances (NPS), including cognitive enhancers (CEs) which can be used in the treatment of certain mental health disorders. While treating cognitive deficit symptoms in neuropsychiatric or neurodegenerative disorders using CEs might have significant benefits for patients, the increasing recreational use of these substances by healthy individuals raises many clinical, medico-legal, and ethical issues. Moreover, it has become very challenging for clinicians to Edited by: keep up-to-date with CEs currently available as comprehensive official lists do not exist. Simona Pichini, Methods: Using a web crawler (NPSfinder®), the present study aimed at assessing National Institute of Health (ISS), Italy Reviewed by: psychonaut fora/platforms to better understand the online situation regarding CEs.
    [Show full text]