Download Product Insert (PDF)

Total Page：16

File Type：pdf, Size：1020Kb

PRODUCT INFORMATION (±)-threo-Isopropylphenidate (hydrochloride) Item No. 19264 CAS Registry No.: 1262795-94-7 Formal Name: (αR,2R)-rel-α-phenyl-2-piperidineacetic acid, 1-methylethyl ester, monohydrochloride O O Synonyms: Dimethylphenidate, Ritalinic Acid isopropyl ester MF: C H NO • HCl H 16 23 2 H FW: 297.8 N Purity: ≥98% Supplied as: A neat solid Storage: -20°C • HCl Stability: ≥1 year Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis. Description (±)-threo-Isopropylphenidate (hydrochloride) (Item No. 19264) is an analytical reference standard that is structurally categorized as a phenethylamine. It is closely related to methylphenidate (Item No. 11639) and has been speculated to act as both a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor.1 This product is intended for forensic and research uses. This product is qualified as a Reference Material that has been manufactured and tested to ISO/IEC 17025 and ISO 17034 international standards for reference materials. Reference 1. Markowitz, J.S., Zhu, H.-J., and Patrick, K.S. Isopropylphenidate: An ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability. J. Child Adolesc. Psychopharmacol. 23(10), 648-654 (2013). WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD SAFETY DATA ANN ARBOR, MI 48108 · USA This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution. PHONE: [800] 364-9897 WARRANTY AND LIMITATION OF REMEDY [734] 971-3335 Buyer agrees to purchase the material subject to Cayman’s Terms and Conditions. Complete Terms and Conditions including Warranty and Limitation of Liability information can be found on our website. FAX: [734] 971-3640 [email protected] Copyright Cayman Chemical Company, 08/26/2019 WWW.CAYMANCHEM.COM.

Copy Link

Recommended publications

Free PDF Download
European Review for Medical and Pharmacological Sciences 2019; 23: 3-15 Use of cognitive enhancers: methylphenidate and analogs J. CARLIER1, R. GIORGETTI2, M.R. VARÌ3, F. PIRANI2, G. RICCI4, F.P. BUSARDÒ2 1Unit of Forensic Toxicology, Sapienza University of Rome, Rome, Italy 2Section of Legal Medicine, Universita Politecnica delle Marche, Ancona, Italy 3National Centre on Addiction and Doping, Istituto Superiore di Sanità, Rome, Italy 4School of Law, University of Camerino, Camerino, Italy Abstract. – OBJECTIVE: In the last decades, phenidate analogs should be undertaken to re- several cognitive-enhancing drugs have been duce the uprising threat, and education efforts sold onto the drug market. Methylphenidate and should be made among high-risk populations. analogs represent a sub-class of these new psy- choactive substances (NPS). We aimed to re- Key Words: view the use and misuse of methylphenidate and Cognitive enhancers, Methylphenidate, Ritalin, Eth- analogs, and the risk associated. Moreover, we ylphenidate, Methylphenidate analogs, New psycho- exhaustively reviewed the scientific data on the active substances. most recent methylphenidate analogs (methyl- phenidate and ethylphenidate excluded). MATERIALS AND METHODS: Literature Introduction search was performed on methylphenidate and analogs, using specialized search engines ac- cessing scientific databases. Additional reports Consumption of various pharmaceutical drugs were retrieved from international agencies, in- by healthy individuals in an attempt to improve stitutional websites, and drug user forums. cognitive faculties is on the rise, whether for aca- RESULTS: Methylphenidate/Ritalin has been demic or recreational purposes1. These substances used for decades to treat attention deficit disor- are stimulants that preferentially target the cate- ders and narcolepsy. More recently, it has been used as a cognitive enhancer and a recreation- cholamines of the prefrontal cortex of the brain to al drug.
[Show full text]
Advisory Council on the Misuse of Drugs
ACMD Advisory Council on the Misuse of Drugs Chair: Dr Owen Bowden-Jones Secretary: Zahi Sulaiman 1st Floor (NE), Peel Building 2 Marsham Street London SW1P 4DF Tel: 020 7035 1121 [email protected] Sarah Newton MP Minister for Vulnerability, Safeguarding and Countering Extremism Home Office 2 Marsham Street London SW1P 4DF 10 March 2017 Dear Minister, RE: Further advice on methylphenidate-related NPS In February 2016, my predecessor Professor Les Iversen wrote to the then minister for Preventing Abuse, Exploitation and Crime, requesting that the Temporary Class Drug Order (TCDO) on seven methylphenidate-related Novel Psychoactive Substances be re-laid for a further 12 months. This TCDO was re-laid until June 2017, to allow the Advisory Council on the Misuse of Drugs (ACMD) more time to collect the evidence required to provide further advice for full control under the Misuse of Drugs Act 1971. The ACMD believes that the TCDO has been effective in reducing the prevalence of these substances and that the TCDO level of control was proportionate in the interim. I am now pleased to present to you the ACMD’s further advice on this matter in the enclosed report. The ACMD’s recommendation for full control applies to the seven substances currently controlled under the TCDO and extends to an additional five closely-related substances. These five similar substances have subsequently appeared on markets following the TCDO and are included in this advice due to their potential for similar harms. Recommendation The ACMD recommends that the
[Show full text]
Methylphenidate-Based
ACMD Advisory Council on the Misuse of Drugs Chair: Professor Les Iversen Secretary: Zahi Sulaiman 1st Floor (NE), Peel Building 2 Marsham Street London SW1P 4DF Tel: 020 7035 1121 [email protected] Minister of State for Crime Prevention Home Office 2 Marsham Street London SW1P 4DF 31 March 2015 Dear Minister, I am writing to recommend that you lay a temporary class drug order (TCDO) pursuant to section 2A of the Misuse of Drugs Act 1971 on a number of methylphenidate-based NPS: ethylphenidate, 3,4-dichloromethylphenidate (‘3,4- DCMP’), methylnaphthidate (‘HDMP-28’), isopropylphenidate (‘IPP’ or ‘IPPD’) and propylphenidate. Methylphenidate-based NPS Methylphenidate is a licensed stimulant pharmaceutical and is controlled in the UK as a Class B controlled drug. The methylphenidate-related materials being marketed as NPS have psychoactive effects so similar to the parent compound that they can be expected to present similar risks to users. Although ethylphenidate is by far the most widely available of this group, other variants are already in the market place. In the short term, to address the widespread availability of methylphenidate-based NPS and the associated problems which are being reported, the ACMD has considered the evidence on methylphenidate-based NPS and recommends control of these NPS by means of a TCDO. The attached report contains the ACMD’s consideration of the evidence concerning methylphenidate-based NPS. 1 In providing this advice, I would like to convey my thanks to Police Scotland, the National Programme on
[Show full text]
Phd Thesis Project: Pharmacological and Toxicological Investigations of New Psychoactive Substances, Supervised by Prof
PHARMACOLOGICAL AND TOXICOLOGICAL INVESTIGATIONS OF NEW PSYCHOACTIVE SUBSTANCES Inauguraldissertation zur Erlangung der Würde eines Doktors der Philosophie vorgelegt der Philosophisch-Naturwissenschaftlichen Fakultät der Universität Basel von Dino Lüthi aus Rüderswil, Bern Basel, 2018 Originaldokument gespeichert auf dem Dokumentenserver der Universität Basel edoc.unibas.ch Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung-Nicht kommerziell 4.0 International Lizenz (https://creativecommons.org/licenses/by-nc-sa/4.0/deed.de). Genehmigt von der Philosophisch-Naturwissenschaftlichen Fakultät auf Antrag von Prof. Stephan Krähenbühl, Prof. Matthias E. Liechti und Prof. Anne Eckert. Basel, den 26.06.2018 Prof. Martin Spiess Dekan der Philosophisch- Naturwissenschaftlichen Fakultät PHARMACOLOGICAL AND TOXICOLOGICAL INVESTIGATIONS OF NEW PSYCHOACTIVE SUBSTANCES “An adult must make his own decision as to whether or not he should expose himself to a specific drug, be it available by prescription or proscribed by law, by measuring the potential good and bad with his own personal yardstick.” ― Alexander Shulgin, Pihkal: A Chemical Love Story. PREFACE This thesis is split into a pharmacology part and a toxicology part. The pharmacology part consists of investigations on the monoamine transporter and receptor interactions of traditional and newly emerged drugs, mainly stimulants and psychedelics; the toxicology part consists of investigations on mechanisms of hepatocellular toxicity of synthetic cathinones. All research described in this thesis has been published in peer-reviewed journals, and was performed between October 2014 and June 2018 in the Division of Clinical Pharmacology and Toxicology at the Department of Biomedicine of the University Hospital Basel and University of Basel, and partly at the pRED Roche Innovation Center Basel at F.
[Show full text]
Model Scheduling New/Novel Psychoactive Substances Act (Third Edition)
Model Scheduling New/Novel Psychoactive Substances Act (Third Edition) July 1, 2019. This project was supported by Grant No. G1799ONDCP03A, awarded by the Office of National Drug Control Policy. Points of view or opinions in this document are those of the author and do not necessarily represent the official position or policies of the Office of National Drug Control Policy or the United States Government. © 2019 NATIONAL ALLIANCE FOR MODEL STATE DRUG LAWS. This document may be reproduced for non-commercial purposes with full attribution to the National Alliance for Model State Drug Laws. Please contact NAMSDL at [email protected] or (703) 229-4954 with any questions about the Model Language. This document is intended for educational purposes only and does not constitute legal advice or opinion. Headquarters Office: NATIONAL ALLIANCE FOR MODEL STATE DRUG 1 LAWS, 1335 North Front Street, First Floor, Harrisburg, PA, 17102-2629. Model Scheduling New/Novel Psychoactive Substances Act (Third Edition)1 Table of Contents 3 Policy Statement and Background 5 Highlights 6 Section I – Short Title 6 Section II – Purpose 6 Section III – Synthetic Cannabinoids 13 Section IV – Substituted Cathinones 19 Section V – Substituted Phenethylamines 23 Section VI – N-benzyl Phenethylamine Compounds 25 Section VII – Substituted Tryptamines 28 Section VIII – Substituted Phenylcyclohexylamines 30 Section IX – Fentanyl Derivatives 39 Section X – Unclassified NPS 43 Appendix 1 Second edition published in September 2018; first edition published in 2014. Content in red bold first added in third edition. © 2019 NATIONAL ALLIANCE FOR MODEL STATE DRUG LAWS. This document may be reproduced for non-commercial purposes with full attribution to the National Alliance for Model State Drug Laws.
[Show full text]
The Misuse of Drugs (Amendment) (England, Wales and Scotland
Title : Control of methylphenidate (Ritalin) based substances IA No: HO0288 Impact Assessment (IA) RPC Reference No: Date: 4/5/17 Lead department or agency: Stage: Final Home Office Source of intervention: Domestic Other departments or agencies: Department of Health, Department for Business, Energy and Industrial Type of measure: Secondary legislation Strategy and The Medicines and Healthcare Products Regulatory Contact for enquiries: James McLellan, Agency Drugs and Alcohol Unit, 0207 035 1885 Summary: Intervention and Options RPC Opinion: Not Applicable Cost of Preferred (or more likely) Option Total Net Business Net Net cost to business per One-In, Business Impact Target Present Value Present Value year (EANDCB in 2014 prices) Three-Out Status £m £m £m Not in scope Not a regulatory provision What is the problem under consideration? Why is government intervention necessary? The Advisory Council on the Misuse of Drugs (ACMD) has provided further advice in relation to a number of methylphenidate (ritalin)-related Novel Psychoactive Substances (NPS) that are currently under a Temporary Class Drug Order (TCDO), which expires on 26 June 2017. The ACMD has considered that the harms associated with these substances are sufficient to constitute a societal problem and therefore recommend these and five further related substances are permanently controlled as Class B drugs under the Misuse of Drugs Act 1971. The ACMD also confirmed on 23 March that they are not aware of any legitimate medicinal, industrial or commercial uses of these substances and as such have recommended that all 12 methylphenidate-related substances be listed as Schedule 1 drugs under the Misuse of Drugs Regulations 2001.
[Show full text]
Drugs and Alcohol Young Person Factsheet
#drugsandalcohol #publichealth5-19service DRUGS AND ALCOHOL FACTSHEET This factsheet will provide you with information and advice about drugs and alcohol, their effects on the body, staying safe and links to helpful websites. Why do people use drugs? People use drugs for a number of reasons such as: to have a laugh to make them feel more confident to fit in with people to make them look hard to fill time because their mates do to get away from their problems. “I turned to drink and drugs to try and make things better but really they were just making things a lot worse. I got into trouble everywhere I went, got into fights for no reason and hurt myself by punching walls.” What are drugs? A drug is a substance that can change someone’s mood or behaviour. This includes alcohol and prescription or over the counter painkillers such as Paracetamol, Ibuprofen, Nurofen etc. Uppers speed up your body and give you extra energy. These include: cocaine, speed (phet), crack, ecstasy Downers slow down your body. These include: alcohol, blues, heroin, cannabis Round the benders/trippy drugs are mind-altering drugs that cause hallucinations. These include: LSD (acid), magic mushrooms, ketamine, cannabis How will drugs affect me? The effect of a drug will depend on: the type of drug the quantity the method by which you take it e.g. inhaling, injecting who you are with and your surrounding how you are feeling and your general health www.cumbria.gov.uk/ph5to19 Uppers can: cause tiredness and depression days after taking the drugs result
[Show full text]
Appendix-2Final.Pdf 663.7 KB
North West ‘Through the Gate Substance Misuse Services’ Drug Testing Project Appendix 2 – Analytical methodologies Overview Urine samples were analysed using three methodologies. The first methodology (General Screen) was designed to cover a wide range of analytes (drugs) and was used for all analytes other than the synthetic cannabinoid receptor agonists (SCRAs). The analyte coverage included a broad range of commonly prescribed drugs including over the counter medications, commonly misused drugs and metabolites of many of the compounds too. This approach provided a very powerful drug screening tool to investigate drug use/misuse before and whilst in prison. The second methodology (SCRA Screen) was specifically designed for SCRAs and targets only those compounds. This was a very sensitive methodology with a method capability of sub 100pg/ml for over 600 SCRAs and their metabolites. Both methodologies utilised full scan high resolution accurate mass LCMS technologies that allowed a non-targeted approach to data acquisition and the ability to retrospectively review data. The non-targeted approach to data acquisition effectively means that the analyte coverage of the data acquisition was unlimited. The only limiting factors were related to the chemical nature of the analyte being looked for. The analyte must extract in the sample preparation process; it must chromatograph and it must ionise under the conditions used by the mass spectrometer interface. The final limiting factor was presence in the data processing database. The subsequent study of negative MDT samples across the North West and London and the South East used a GCMS methodology for anabolic steroids in addition to the General and SCRA screens.
[Show full text]
NFLIS-Drug Selected Substance List
2017-2020 NFLIS-Drug Substance List (Sorted by Date) Date Added NFLIS Substance Name Synonyms Chemical Name Structure InChI Formula to NFLIS- Drug InChI=1S/C16H20BrN/ c17-14-1-3-15(4-2-14)18-16-12-6-10-5-11 Bromantane ladasten N-(4-bromophenyl)adamantan-2-amine C16H20BrN 12/7/20 (8-12)9-13(16)7-10/h1-4,10-13,16,18H, 5-9H2 InChI=1S/C21H29FN2O3/ c1-4-27-21(26)19(15(2)3)23-20(25)17-14- ethyl 2-(1-(5-fluoropentyl)-1H-indole-3-carboxamido)-3- 5F-EMB-PICA EMB-2201; 5-fluoro-EMB-PICA 24(13-9-5-8-12-22)18-11-7-6-10-16(17)18 C21H29FN2O3 11/12/20 methylbutanoate /h6-7,10-11,14-15,19H, 4-5,8-9,12-13H2,1-3H3,(H,23,25) InChI=1S/C20H27FN2O3/ c1-20(2,3)17(19(25)26-4)22-18(24)15-13- methyl 2-(1-(4-fluorobutyl)-1H-indole-3- 4F-MDMB-BUTICA 4-fluoro-MDMB-BUTICA; 4F-MDMB-BICA 23(12-8-7-11-21)16-10-6-5-9-14(15)16/ C20H27FN2O3 10/23/20 carboxamido)-3,3-dimethylbutanoate h5-6,9-10,13,17H,7-8,11-12H2,1-4H3,(H, 22,24) InChI=1S/C10H14BrNO2/ 4-methoxy-6-[(1E)-2-phenylethenyl]-5,6-dihydro-2H- 2Br-4,5-Dimethoxyphenethylamine 2-bromo-4,5-dimethoxyphenethylamine c1-13-9-5-7(3-4-12)8(11)6-10(9)14-2/ C10H14BrNO2 10/2/20 pyran-2-one h5-6H,3-4,12H2,1-2H3 InChI=1S/C16H22FNO/ 4-fluoro-3-methyl-alpha-PVP; 4F-3-methyl-alpha- c1-3-6-15(18-9-4-5-10-18)16(19)13-7-8-1 4F-3-Methyl-alpha-PVP 4-fluoro-3-methyl-alpha-pyrrolidinopentiophenone C16H22FNO 10/2/20 pyrrolidinovalerophenone 4(17)12(2)11-13/h7-8,11,15H, 3-6,9-10H2,1-2H3 InChI=1S/C21H26N4O3/ N,N-diethyl-2-[2-(4-methoxybenzyl)-5-nitro-1H- c1-4-23(5-2)12-13-24-20-11-8-17(25(26)2 Metonitazene C21H26N4O3 9/15/20 benzimidazol-1-yl]ethanamine
[Show full text]
Is the Main Law on Drug Classification in the UK. It Classifies Drugs B
Misuse of Drugs Act (1971) is the main law on drug The Psychoactive Substances Act (2016) has come into classification in the UK. It classifies drugs by the degree of force on 26 May 2016. social harm. The most severe crimes can be punished with a Under the PSA it is an offence to Produce, Supply, Offer to life sentence and unlimited fine. supply, Possess with intent to supply, or Possess on custodial It is amended to add new substances as evidence on their premises and to Import or Export Psychoactive Substances i.e. harm is gathered. Temporary Class Drug Orders (TCDO’s) can any substance intended for human consumption that is capable 24 January 2017 be placed on substances which are suspected to be harmful of producing psychoactive effects. It carries a maximum while evidence is gathered to support classification. sentence of up to 7 years and unlimited fine. Class A Drugs Class B Drugs Class C Drugs Produced on Max. Possession: 7 years & fine Possession: 5 years & fine Possession: 2 years & fine Penalty Supply: life & fine MoDA(1971) Supply: 14 years & fine MoDA(1971) Supply: 14 years & fine MoDA(1971) LSD Cannabis Anabolic steroids LSD related substances Synthetic Cannabinoids GHB and GBL - Tryptamines - Mephedrone (Meow Meow) Khat AMT (Banned Oct 2014) - ‘Spice’/’Black Mamba’ containing MSJ 5-MeO–DALT AM-2201 or UR-144 Tranquilisers and Benzodiazepines (Banned Jan 2015) Amphetamines including - ALD-52, AL-LAD, ETH-LAD, PRO- Barbiturates - Rohypnol, LAD and LSZ Codeine - Diazepam, (Banned Jan 2015) Naphyrone – ‘Rave’, ‘NRG1’, ‘NRG-1’, - Temazepam, Heroin ‘Energy1’, ‘Energy-1’ - Phenazepam Heroin related substances 2-DPMP, D2PM and - AH7921 (opiate derivative) diphenylmethylpyrrolidine (stimulant Banned Oct 2014 found in ‘Ivory Wave’ NPS) Cocaine Methoxetamine (MXE) Magic Mushrooms Ketamine Crack Benzofuran Compounds Ecstasy - Benzo Fury, White Pearl, 6-APDB, PMA 6-APB, 5-APDB, 5-APB (Banned Methadone 10/06/2014) Methylphenidate (Ritalin) (unless prescribed).
[Show full text]
World of Cognitive Enhancers
ORIGINAL RESEARCH published: 11 September 2020 doi: 10.3389/fpsyt.2020.546796 The Psychonauts’ World of Cognitive Enhancers Flavia Napoletano 1,2, Fabrizio Schifano 2*, John Martin Corkery 2, Amira Guirguis 2,3, Davide Arillotta 2,4, Caroline Zangani 2,5 and Alessandro Vento 6,7,8 1 Department of Mental Health, Homerton University Hospital, East London Foundation Trust, London, United Kingdom, 2 Psychopharmacology, Drug Misuse, and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, 3 Swansea University Medical School, Institute of Life Sciences 2, Swansea University, Swansea, United Kingdom, 4 Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy, 5 Department of Health Sciences, University of Milan, Milan, Italy, 6 Department of Mental Health, Addictions’ Observatory (ODDPSS), Rome, Italy, 7 Department of Mental Health, Guglielmo Marconi” University, Rome, Italy, 8 Department of Mental Health, ASL Roma 2, Rome, Italy Background: There is growing availability of novel psychoactive substances (NPS), including cognitive enhancers (CEs) which can be used in the treatment of certain mental health disorders. While treating cognitive deficit symptoms in neuropsychiatric or neurodegenerative disorders using CEs might have significant benefits for patients, the increasing recreational use of these substances by healthy individuals raises many clinical, medico-legal, and ethical issues. Moreover, it has become very challenging for clinicians to Edited by: keep up-to-date with CEs currently available as comprehensive official lists do not exist. Simona Pichini, Methods: Using a web crawler (NPSfinder®), the present study aimed at assessing National Institute of Health (ISS), Italy Reviewed by: psychonaut fora/platforms to better understand the online situation regarding CEs.
[Show full text]
Toxicology Reference Material
toxicology Toxicology covers a wide range of disciplines, including therapeutic drug monitoring, clinical toxicology, forensic toxicology (drug driving, criminal and coroners), drugs in sport and work place drug testing, as well as academia and research. Those working in the field have a professional interest in the detection and measurement of alcohol, drugs, poisons and their breakdown products in biological samples, together with the interpretation of these measurements. Abuse and misuse of drugs is one of the biggest problems facing our society today. Acute poisoning remains one of the commonest medical emergencies, accounting for 10-20% of hospital admissions for general medicine [Dargan & Jones, 2001]. Many offenders charged with violent crimes, or victims of violent crime may have been under the influence of drugs at the time the act was committed. The use of mind-altering drugs in the work place, or whilst in control of a motor vehicle places others in danger [Drummer, 2001]. Performance enhancing drugs in sport make for an uneven playing field and distract from the core ethic of sportsmanship. Patterns of drug abuse around the world are constantly evolving. They vary between geographies; from one country to another and even from region to region or population to population within countries. With a European presence, a wide reaching network of global customers and distributors, and activate participation in relevant professional societies, Chiron is well positioned to develop and deliver relevant, and current standards to meet customer demand in this challenging field. Chiron AS Stiklestadvn. 1 N-7041 Trondheim Norway Phone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org.
[Show full text]