IIIHIIIHIIII O USOO5357636A United States Patent (19) [11] Patent Number: 5,357,636 Dresdner, Jr. et al. (45) Date of Patent: Oct. 25, 1994

54 FLEXIBLE PROTECTIVE MEDICAL sis', 1976, New England Journal of Medicine, 294(3): GLOVES AND METHODS FORTHER USE pp. 1286-1287. 76 Inventors: Karl P. Dresdn O Viljanto, "Disinfection of Surgical Wounds Without 76) St., Apt. its. 3:...ith Inhibition of Normal Wound Healing', 1980, Arch., N.Y. 10036; Kenneth H. Dangman, Surg, 115, pp. 253–256. 400 Riverside Dr., Apt. #1A, New Rodeheaver, et al., "Bactericidal Activity and Toxicity York City, N.Y. 10032; Edward A. of Iodine-Containing Solutions in Wounds', 1982, Jazlowiecki, 15 Sachems Trail, west Arch. Surg, 117, pp. 181-186. Simsbury, Conn. 06092 (List continued on next page.) 212 Appl ... No.:NO. 906,829 Primary Examiner-Clifford D. Crowder 22 Filed: Jun. 30, 1992 Assistant Examiner-Amy B. Vanatta 51) Int. Cl...... A41D 13/10; A41D 19/00 57 ABSTRACT 52 U.S.C...... 2/1617; 2/167; (57) 2/168; 2/169 A flexible protective medical glove containing a non 58) Field of Search ...... 2/161 R, 168, 167, 169, liquid antiseptic composition and methods for its use are 2/164, 159, 1616, 1617, 1618, 16, 21; 128/292, disclosed. The glove comprises a thin inner layer and a 306, 307, 842, 844; 604/349; 427/2 thin outer layer of material; preferably the outer layer is a more elastic and less plastic layer than the inner layer. 56) References Cited A compartment between the layers of the glove is capa U.S. PATENT DOCUMENTS ble of providing a non-liquid antiseptic composition 2,541,103 2/1951 Sander . which comprises an antiseptic in a non-liquid composi 3,633,216 1/1972 Shonholtz ...... 2/168 tion. The non-liquid antiseptic composition may also 4,526,828 7/1985 Fogt et al. . contain a surface-active agent, an algesic agent, a color 4,771,482S. 9/198823 SEM"Shlenker Poo-oooowoon a an oppos 2/161R ant,modifying a vasoconstrictive agent. An object agent, puncturing an odorant, the or aglove viscosity wall 4,935,260 6/1990 Shlenker ...... is can become coated with the non-liquid antiseptic com 5,003,628 4/1991 Miyake et al. . position and can automatically transfer some of the 5,019,604 5/1991 Lemole . antiseptic composition from the glove onto the hand 5,024,852 6/1991 Busnel et al...... 2/161 RX and into a hand wound should the object cause a 5,031,245 7/1991 Milner . wound; useful as an immediate preventative antiseptic 5,045,341 9/1991 Shlenker ...... 2/922 treatment to help to decontaminate the hand and hand 5,128,168 7/1992 Shenker et a wound of infectious pathogens that may have been 5,130,159 7/1992 Shlenker et al...... 2/167 X transferred there by the object. The treatment can help FOREIGN PATENT DOCUMENTS to protect a gloved individual such as a surgeon, a medi WO91/10409 7/1991 PCT Int'l Appl. . cal doctor, a health care worker, a law enforcement 9014048 11/1990 World Int. Prop. O...... 2/21 officer, a dentist or any worker whose work may place them at some risk of becoming contaminated through OTHER PUBLICATIONS the hands by an infectious pathogen including the Stecher, et al., "Nonoxynol”, 1968 8th ed., The Merck AIDS virus or hepatitis B virus. Index, p. 745. Maki, "Lister Revisted: Surgical Antisepsis and Asep- 20 Claims, 7 Drawing Sheets

5,357,636 Page 2

OTHER PUBLICATIONS tients with Human Immunodeficiency Virus', 1990, Surgery-Gynecology & Obstetrics, vol. 171, No. 2, Simmons, et al., “CDC Guidelines for the Prevention pp. 99-106. and Control of Nosocomial Infections' (Guideline for Henderson, et al., “Risk of Occupational Transmission hospital environmental control), Am. Journal of Infec of Human Immunodeficiency Virus Type 1 (HIV-1) tion Control, 1983, 113), pp. 91-120. Associated with Clinical Exposures', 1990, Annals of Simmons, et al., “CDC Guidelines for the Prevention Internal Medicine, vol. 113, pp. 740–746. and Control of Nosocomial Infections' (Guideline for Beekmann, et al., "Risky Business: Using Necessarily prevention of surgical wound infections), Am. Journal Imprecise Casualty Counts to Estimate Occupational Risks for HIV-1 Infection', 1990, Infection Control of Infection Control, 1983, 114), pp. 133-143. Hospital Epidemiology, 117, pp. 371-379. Hicks, et al., “Inactivation of HTLV-III/Lav-Infected Bloomfield, et al., "Evaluation of Hypochlorite-Releas Cultures or Normal Human Lymphocytes. By Nonox ing Disinfectants Against the Human Immunodefi ynol-9 in Vitro', 1985, Dec. 21/28, The Lancet, pp. ciency Virus (HIV)', 1990, Journal of Hospital Infec 422-1423. tion, 15, pp. 273-278. Harvey, "Antiseptics and Disinfectants; Fungicides; Johnson, et al., “Efficacy of Glove Combinations in Ectoparasiticides', 1985, In: The Pharmacological Reducing Cell Culture Infection. After Glove Puncture Basis of Therapeutics; 7th ed., Chapter 41, pp. 959-979. With Needles Contaminated With Human Immunodefi Weiss, et al., “HTLV-III Infection Among Health Care ciency Virus Type 1", 1991, Infection Control and Hos Workers', 1985; The Journal of the Am. Med. Assoc., pital Epidemiology, 127, pp. 435-438. vol. 254, No. 15; pp. 2089-2093. Panlilio, et al., "Blood Contacts During Surgical Proce Rietmeijer et al., “Condoms as Physical and Chemical dures', 1991, Journal of American Medical Association, Barriers Against Human Immunodeficiency Virus,” 265(12), pp. 1533-1537. 1988, The Journal of the Am. Med. Assoc., 295.12, pp. Gross, "Many Doctors Infected with AIDS Don't Fol 1851-1853. low New U.S. Guidelines', 1991, The New York Newsom, et al., “What is in the Surgeon’s Glove?', Times, vol. CXL. . . No. 48, 696, p. 1. 1988, Journal of Hospital Infection, 11supplement A), Orentlicher, “HIV-Infected Surgeons: Behringer v. pp. 244-259. Medical Center', 1991, The Journal of American Medi Bartlett, “Testing for HIV Infection: Recommendations cal Associations, 2668), pp. 1134-1137. for Surgeons', 1988, Am. College of Surgeons Bulletin, Zanowiak, "Skin Infections: The Role of OTC Ther 733), pp. 4-10. apy”, Jun. 1991, U.S. Pharmacist pp. 40-47. Gerberding, et al., “Risk of Exposure of Surgical Per Mast, "Factors Predicting Infectivity Following Need sonnel to Patients’ Blood During Surgery at San Fran lestick Exposure to HIV: A Invitro Model”, 1991, Clin cisco General Hospital', 1990, The New England Jour ical Research, 39(1): p. 58A. nal of Medicine, 322(25) pp. 1788-1793. Wright, "Mechanisms of Glove Tears and Sharp Inju Montefiori, et al., “Effective Inactivation of Human ries Among Surgical Personnel,' 1991, Journal of Immunodeficiency Virus With Chlorhexidine Antisep American Medicical Association, 266(12): 1668-1671. tics Containing Detergents and Alcohol', 1990, Journal Boscia, Peterson, Szpalski, Panlilio & Gerberding, Let of Hospital Infection, 15, pp. 279-282. ters to the Editor: “Surgery, AIDS, and Hepatitus B', Speller, et al., “Acquired Immune Deficiency Syn 1991, Journal of American Medical Association, 266(10: drome: Recommendations of a Working Party of the 1360-1362. Hospital Infection Society”, 1990, Journal of Hospital Belkin, L. "Fear of Disease Changing How Doctors Infection, 15 pp. 7-34. Work”, Apr. 7, 1992, A1, B2, New York Times. Sanders, et al., "Outer Gloves in Orthopaedic Proce Assoc. Press, "Teen-Agers and AIDS: The Risk Wors dure', 1990, The Journal of Bone and Joint Surgery, ens”, Apr. 14, 1992, C3, New York Times-Medical Inc., 72-A6, pp. 914-917. Science Section. Closs & Tierney, “Theatre Gowns: A Survey of the Remington's Pharmaceutical Sciences: 1965, "Suspen Extent of User Protection', 1990, Journal of Hospital sions', pp. 455-459; Medicated Applications pp. Infection, 15, pp. 375-378. 525-556; Antimicrobial Drugs, pp. 1228-1252. Mandlebort, et al., “A Survey of Exposure, Practices Remington's Pharmaceutical Sciences: 1990, "Antimi and Recommendations of Surgeons in the Care of Pa crobial Drugs', pp. 1163-1241. U.S. Patent Oct. 25, 1994 Sheet 1 of 7 5,357,636

FIG. 1A

U.S. Patent Oct. 25, 1994 Sheet 2 of 7 5,357,636

F.G. 1B U.S. Patent Oct. 25, 1994 Sheet 3 of 7 5,357,636

U.S. Patent Oct. 25, 1994 Sheet 4 of 7 5,357,636

FIG. 2B

U.S. Patent Oct. 25, 1994 Sheet 5 of 7 5,357,636

FIG. 2C

U.S. Patent Oct. 25, 1994 Sheet 6 of 7 5,357,636

FG. 3

U.S. Patent Oct. 25, 1994 Sheet 7 of 7 5,357,636

FG. 4

5,357,636 1. 2 to a surface of a surgical wound from a surgeon's hands. FLEXIBLE PROTECTIVE MEDICAL GLOVES Nonsterile latex medical gloves are also known in the AND METHODS FOR THEIR USE field as examination gloves; they are used during non sterile procedures; are made available usually in a size FIELD OF THE INVENTION that can suitably fit either hand and are often packaged The present invention is a flexible protective medical in bulk, for example in quanities of 50 per box. Non-ster glove that relates to the thin-walled medical glove that ile procedures include the medical examination of doctors, health care workers and other workers can human body surfaces, body invaginations and body wear on one or both hands as a physical barrier form of orifices; nonsterile medical gloves are also worn for protection. In particular the present invention is a glove 10 protecting the hands of medical, research or hospital containing an antiseptic composition other than a liquid workers from contact with hazardous substances and antiseptic composition within the glove wall;:the non surfaces. Examples of hazardous substances and Sur liquid antiseptic composition comprises an antiseptic in faces include but are not limited to the following exam a non-liquid composition; for example, the composition ples: biological waste products such as feces and urine, may comprise a powder, a paste, a foam, a gel, a coat 15 soiled wound dressings, garments or other materials, ing, a solid layer, a semi-solid foam, a putty or a state of syringe needles, other medical devices, irritating or matter that lacks the ability to flow like a liquid. toxic liquids or chemicals, biological toxins, radioactive No useful medical glove is puncture-proof; when an substances, and infectious pathogens. For the present individual wears a conventional medical glove, the thin invention, the term "infectious pathogens' is meant to glove wall can readily become punctured by an object 20 include but is not limited to the following pathogens: and the hand underneath the glove may become viruses, bacteria, fungi, yeasts, rickettsia, prions, multi wounded. If the object is contaminated with an infec cellular parasites, the spores of infectious pathogens, tious pathogen, then the hand and the hand wound may and the like. become contaminated and the individual may suffer a systemic pathogenic infection. A glove in accordance 25 At least three kinds of glove wall failure are known with the present invention can be used to help to pre currently plague the currently known types of medical vent the hand and the hand wound from a contamina gloves. First, about two percent of standard latex gloves tion that might cause a systemic infection; the invention have inherent microscopic perforations after manufac is urgently needed for example for use in medical work turing that can be easily be permeated by small infec environments that may harbor the AIDS virus, the 30 tious pathogens such as a virus. Secondly, during their hepatitis B virus, or other infectious pathogens. When use, medical gloves may acquire additional perfora an object punctures a glove in accordance with the tions, small tears or small punctures which may go present invention, the object can contact and can then unnoticed but could provide a pathway for infectious become coated with some of the antiseptic composition. pathogens to contact the hands of the glove wearer, If the object also causes a wound to the hand, then some 35 particularly when the glove is contacted by bloody of the antiseptic composition coating the object may be contaminated body fluids containing the infectious transferred to the hand and deposited into the hand pathogen. If an infectious pathogen contacts human wound, thereby helping to provide an immediate and skin, the individual may eventually become systemi automatic antiseptic treatment of the contaminated cally infected with the pathogen. Thirdly, if the glove is hand and hand wound. In general, the non-liquid anti accidentally punctured by an object that is contami septic composition used in the present invention, lack nated with an infectious pathogen, a gloved hand may ing the ability to flow like a liquid can not leak from a become contaminated with an infectious pathogen. glove wall puncture. For some embodiments of the When a glove wall is punctured, the glove puncturing present invention, manual massage of the gloved hand object may have a sharp edge like a hypodermic needle, may be used as a means for causing extrusion of the 45 suture needle, or scapel blade but an object with blunt non-liquid antiseptic composition from the glove wall edges can also puncture a glove wall. When the cur puncture to increase the dispersion of the non-liquid rently available medical gloves are worn on the hands, antiseptic composition onto the hand and into hand the gloves are not designed nor have the capacity to wound as an additional treatment. protect the hands when a glove is punctured by an 50 object that is contaminated with an infectious pathogen. BACKGROUND OF THE INVENTION The prevalence of vital disease caused by infectious In general, latex gloves are worn during a medical pathogens in the human population has created an ur procedure to provide a physical barrier between the gent need for more protective medical gloves that re patient's body or tissues and the hands, wrist and arm tain their medical utility. Currently, the most feared regions of a health care practitioner such as a physician, 55 infectious pathogen is the human immunodeficiency nurse, phlebotomist and the like. The gloves must be virus (HIV). When a human is infected with HIV, a flexible so that the manual dexterity of the health care gradual destruction of the human immune system re practitioner or worker is not significantly decreased. sults over several years and this leads to Acquired Im The gloves are usually well-fitting and comfortable so mune Deficiency Syndrome (AIDS), an illness which is that glove wear does not cause hand fatigue or discom generally ultimately fatal. In general, antiviral medical fort. treatments are of limited utility. Vaccines are of limited Disposible sterile and nonsterile latex medical gloves utility because the HIV surface proteins mutate quickly are available. Sterile latex medical gloves are also and immunologically resistant strains of HIV evolve. known in the field as surgical gloves; they are sterilized Thus there is no known medical cure for HIV infection. at the glove factory; are made available typically as a A person who tests positive for HIV antibodies knows pair in a specific size and are sealed in a sterile package. that they have been exposed to and probably harbor Surgical gloves are most often used for sterile field HIV in their body. Hepatitis B virus (HBV) is another surgery to prevent a transfer of an infectious pathogen virus that can lethally infect a human. There is an effec 5,357,636 3 4. tive anti-HBV vaccine, but the vaccination treatment is The United States Center For Disease Control (U.S. a prolonged and expensive process. Better medical CDC) has issued guidelines for the prevention and con gloves could help to lessen the chance of vital infection. trol of nosoconial infections, for hospital environment Likewise, better medical gloves would be useful to control, and for control of surgical wound infections lessen the chance of infection from any infectious patho (See publications by Simmons, B. P., 1983). The U.S. gen. CDC has reported that a clean wound (a wound that is Medical gloves are commonly made from elastomeric initially pathogen-free) has only a 1 to 5 percent average materials such as latex rubber or plastic. Materials for a risk of becoming infected whereas a contaminated glove may also be obtained from a plant fiber such as wound (a wound exposed to an infectious pathogen) has cotton, from an animal secretion such as silk, from an 10 a 15 to 17 percent average risk of becoming infected. animal tissue such as the skin or intestine, from a mineral Furthermore, it was found that a dirty wound (a wound or from a metal. The material(s) used to manufacture a exposed to biological or environmental liquid and solid medical glove should be flexible and should be capable waste which may be contaminated with an infectious of being made into a fiber or a thin sheet. pathogen) has more than a 27 percent average risk of A second pair of gloves may be worn over the first 15 becoming infected. Therefore, an infection is much pair of gloves to increase the thickness of their physical more likely to occur in a dirty or contaminated wound barrier protection. Multiple pairs of medical gloves can than in a clean wound. Surgeons have administered an be worn provided that fine dexterous hand work can antiseptic solution directly into a wound as an irrigation still be done. However, if two or more pairs of gloves solution (See also Maki, D. C, 1976). Furthermore the are worn, the medical work by the gloved hand can 20 U.S. CDC guidelines advise doctors and health care become difficult and tiring. workers to wash their hands with an antiseptic deter Thick-walled work gloves have been constructed gent to reduce the microbial (infectious pathogen) con using the same materials that can be used to make thin tamination on their hands before they wear medical walled gloves. However, thick-walled gloves are inflex gloves. Thus the cleaning of a wound and antiseptic ible and this property has generally limited their use by 25 decontamination of the hands are established treatment most medical doctors, health care workers, skilled means for decreasing the risk of infection in a wound. workers and the like workers. A number of thick The U.S. CDC has also suggested that antiseptics are walled work gloves have been developed to protect a more effective antimicrobial agents than soap and wa hand from a serious cut or from a puncture wound by an ter, but has pointed out that frequent exposure of the object. For example, thick-walled cut-resistent gloves 30 skin with an antiseptic is often more irritating than skin have been developed to protect the hands in animal exposure to soap and water. Thus, prolonged or re slaughter houses where meat is manually cut (See U.S. peated skin exposure to antiseptic compositions is ill-ad Pat. No. 4,526,828 and PCT WO 91/10409). However, vised. a puncture-resistant glove has not been developed that In 1987, the U.S. CDC issued the recommendation is also flexible to the degree needed by skilled medical 35 that medical examination gloves be worn as a “Univer personnel and the like who must use there hands skill sal Precaution'. To adhere to the Universal Precaution fully and require protective gloves. Guidelines, doctors and other medical personnel are A glove in accordance with the present invention is expected: (1) to assume that each patientis infected with relatively thin-walled and flexible so that the glove can human immunodeficiency virus (HIV) and thus to wear be comfortably worn and easily used by medical per a new pair of gloves with each new patient, and (2) to Sonnel and the like workers as are conventional medical remove their gloves and to wash their hands immedi gloves. In addition, like a conventional medical glove, ately if their hands appear to have become contami the present invention is capable of becoming punctured nated with blood or other body fluids (See Bartlett, J. by an object. G., 1988). The present invention has important, novel additional 45 Although medical workers are well aware of the functions. Generally when an object punctures a glove utility of an antiseptic in the prevention of skin infection in accordance with the present invention, the glove by and wound infection, medical glove wearers may not a number of processes can immediately and automati always be able to comply with the proposed U.S. CDC cally begin to help to protect the hand and any hand guidelines in a competent manner. It may be inconve wound beneath the glove from becoming infected with 50 nient or impossible for a glove wearer to immediately an infectious pathogen should the object have been remove a damaged or contaminated glove during sur contaminated with an infectious pathogen. gery or during a stressful medical emergency. Such a A recent study of accidental blood contact during delay in glove removal may be dangerous for the glove hospital surgical procedures in burn, trauma, orthope wearer. The time delay may permit the blood circula dic, general, gynecology, and plastic surgical services 55 tion of the glove wearer to become more contaminated concluded that surgical gloves are an important means with an infectious pathogen. Delayed disinfection of the for preventing a substantial percentage of the blood hand or hand wound with an antiseptic may be an inef contacts with the hands (Panlilo et al., 1991). Blood and fective means for preventing the systemic spread of an body fluids can be contaminated with infectious patho infectious pathogen in an individual. The glove wearer gens such as HIV (also sometimes known as the AIDS may delay glove removal and decontamination of the virus) and the Hepatitis B virus. Because many sub hand or hand wound with an antiseptic because the stances or material objects can temporarily harbor an glove puncture was not perceived; the the wound may infectious pathogen, medical workers are made aware not be not felt immediately or bleeding from the wound of the risks of becoming contaminated from contacting may be so minor that it is not immediately noticed. It is soiled objects and body fluids from infected individuals. 65 thus a serious problem that some medical glove wearers Medical workers are advised to wear medical gloves in may unwittingly delay a medical treatment of their any environment which may contain infectious patho gloved hands when a hand has become injured by a gens (Panlilo et al., 1991). pathogen-contaminated object. 5,357,636 5 6 There has been an obvious increase in the wearing of facilities include any government, military, commercial, medical gloves in many health care work environments industrial, or biotechnological production, research and following adoption of the Universal Precautions Guide testing areas. Medical gloves in accordance with the lines and following the epidemic growth of AIDS in the present invention are also useful protective hand wear human population. Because it is not known with cer in areas or in work which may include but is not limited tainty exactly which work environments can harbor an to the following examples: public and business building infectious pathogen such as HIV, medical gloves are maintenance work and cleaning, outdoor public areas now routinely worn by many medical or public workers work, restaurant work, sports clubs, spas, health clubs, whenever they suspect they may be at risk of any kind massage parlors, building rehabilitation and clean-up of accidental infection by any infectious pathogen. The 10 work; guard work in jails, prisons, and other crimminal present invention may be usefully worn in many work confinement facilities. Gloves in accordance with the environments and during many kinds of work. The present invention may be useful during travel in public work environments and kinds of work in which gloves or private vehicles used to provide surface, under in accordance with the present invention may be used ground, water, underwater, air, aerospace or even outer include but are not limited to the following examples: 15 space transport conceivably may harbor infectious hospitals, medical clinics, private doctor offices, emer pathogens. gency medical work, medical ambulance work, fire rescue work, medical practice areas involving AIDS Conventional medical gloves are often worn to pro patients, surgery, gynecology, human fertility work, tect the hands of an individual from coming into physi urology, general medicine, pathology, epidemiology, cal contact with an infectious pathogen that infects microbiology, neurology, orthopedics, radiology, on another individual. Gloves in accordance with the pres tology, nursing, dentistry, podiatry, psychiatry, psychi ent invention can provide superior protection for the atric hospitals, hospices, other medical practices and glove wearer compared to conventional medical gloves specialties, kidney dialysis centers, diagnostic medical when the glove wearer is within possible contact of imaging-testing and operations facilities, hospital emer 25 individuals who are at risk of being infected with an gency waiting rooms, emergency hospital ambulatory infectious pathogen. Individuals who at risk of being care, clinics for drug rehabilitation, donor organ and infected with an infectious pathogen include but are not tissue preservation banks and labs, blood banks, blood limited to the following examples: a person infected testing and related analytical chemistry labs, sperm with the AIDS virus, a person infected with hepatitis B banks, sperm testing labs, basic and clinical medical 30 virus or other viruses, a person with a bacterial infec research labs, medical instrument cleaning, sharpening tion, a hospital patient, a health care patient, an intrave and repair facilities, hospital patient rooms, hospital nous drug user, a prostitute, a gang member, a homeless operating rooms, cleaning and maintenance work, hos person, a mentally-ill person, a person suspected of or pital laundries, hospital cafeterias, other hospital patient engaged in criminal activity, a captured or convicted or food service work, hospital morgues, funeral homes and 35 imprisoned criminal; an illegal immigrant, an immigrant related work areas that study or handle dead human from a known HIV-infested population, a new immi bodies and tissues, medical and public waste or garbage grant, a homosexual or bisexual individual, a sexually collection areas, disposal areas and containers for promiscuous individual, and a chronically-ill, elderly or human blood and disposible medical utensils, work with incapacitated person who is at an increased risk of har blood products, urine products or any human body boring an infectious pathogen. In addition, according to products, hospital trash and other disposible waste areas researchers based upon a U.S. survey of more than which might contain medical waste, work with sharp 11,000 students, it is believed that one in five American contaminated objects such as needles, syringes, wires, teenagers are at higher risk for acquiring AIDS because catheters, and intravenous sets, plastic and glass tubes they have had sexual contact with several partners (four and pipettes, glass slides, scalpel blades, and the like; 45 or more persons) during their teenage years (See The disposible medical instruments and work areas involved New York Times, Medical Science Section C3, dated in surgical instrument handling, repair and cleaning, Apr. 14, 1992 by Associated Press). Thus the risk clothing and medical assist areas; areas of medical gar among teenagers for acquiring AIDS may increase as bage removal and medical sanitation work, medical more and more teenagers become carriers of the AIDS work in nursing or retirement homes, and cleaning or 50 virus. industrial operations in any building where there may A glove in accordance with the present invention be any risk of a pathogenic infection. Surgical gloves may also usefully protect an individual under other and/or examination gloves in accordance with the pres circumstances. Animals, plants, soil, water, the air, and ent invention may also be used in animal medicine and various forms of environmental pollution are capable of during general work with animals in research, on farms 55 supporting colonies of infectious pathogens which may or ranches with animals, in veterinary and animal hus infect an individual. Thus workers in many nonmedical bandry practices and pet stores, in work with Zoo ani environments can also become contaminated with an mals, and in similar work where there may be some risk infectious pathogen. Such nonmedical workers include of contact with an infectious pathogen. Gloves in accor but are not limited to the following workers: law en dance with the present invention may also provide use forcement workers, police, state trooper, national ful protection from physical contact with infectious guard, military personnel, traffic police, transit police, pathogens that may exist in potentially infectious, non jail and prison workers, park workers and park cleaners, medical technical areas, scientific areas and other work sanitation workers, city morgue workers, hospital areas including but not limited to the following exam morgue workers, funeral home workers, and cemetery ples: industrial, military, or other research work that workers, waste and water treatment facility workers, involves work with infectious pathogens used in molec street cleaners, sewer workers and other municipal ular biology or molecular genetics, recombinant molec workers, persons cleaning public bathrooms and porta ular genetics, fermentation and vaccine production; the ble toilet maintainance workers. 5,357,636 7 8 In addition, flexible protective medical gloves in ac by a glove in accordance with the present invention; cordance with the present invention can be used by any thus use of the term "hand” for some embodiments of doctor, dentist, health care worker and the like or other the present invention may refer to the fingers, all Sur individual who choses to continue working after they faces of the hand, the wrist, the forearm, and may refer have tested seropositive with an infectious pathogen even to the surfaces of the arm up to the armpit and the such as for example HIV or hepatitus B virus (See News shoulder. York Times article by Jane Gross, dated Aug. 18, 1991). Health care workers and other professionals who It is particularly important for infected medical person care for patients with AIDS know that they may be nel to wear protective medical gloves so that they do come infected with the AIDS virus (HIV) from their not transmit their infection to another person. O work with AIDS patients. It is clear that as a result of If an object cuts, or otherwise penetrates a thin medi the AIDS epidemic, medical doctors and health care cal glove wall while it is being worn on a hand, the workers now work with increased anxiety and fear of physical barrier protection provided by the glove is contracting AIDS (See “Fear of Disease Changes How immediately lost. Such an accident to a glove while it is Doctors Work, New York Times dated Apr. 7, 1992, being worn may also wound the hand and this wound 15 page 1, by Lisa Belkin). Medical workers know that an ing may expose the blood circulation of the individual accidental hand wound during their professional work to the surface of the glove-puncturing object; becoming may infect them with HIV and shorten their lives (Ger wounded is particularly traumatic and serious if the berding and Schecter, 1991). Each time a gloved handis surface of the glove-puncturing object may be contami wounded by an object contaminated with blood or nated with an infectious pathogen such as HIV. 20 other body fluids, the wounded medical worker must Medical personnel know that wearing a conventional psychologically deal with the possibility that the wound medical glove can not adequately protect a hand from a was contaminated with HIV, and that they are at some glove-puncturing object contaminated with HIV. HIV generally-unclear risk of acquiring an HIV infection. contamination to a gloved individual can take place if a Thus, there is clearly an urgent need for a more protec Syringe needle contaminated with AIDs-tainted blood 25 tive medical glove than is currently available, that can punctures the glove and wounds the hand. A variety of provide superior protection for the glove wearer hand medical objects have caused an instant HIV inoculation when their hand is wounded by an object that may be to the hands of health care workers wearing standard contaminated with an infectious pathogen such as HIV. Surgical or examination gloves (See Henderson et al., Some medical doctors and health care workers have 1990; Beekman et al., 1990; Panlilo et al., 1991). 30 indicated they would not disclose if their hand was For the present invention, the term glove wall punc wounded or injured during work by an object possibly ture is broadly defined to encompass a glove wall punc contaminated with HIV nor would they disclose to ture caused by any object or by any process. A glove their co-workers if their blood were to test positive for wall puncture may be caused by any physical object antibodies to HIV antigens because such disclosure capable of cutting, biting, abrading, puncturing, stab 35 would reveal to their co-workers that they might have bing, crushing, or otherwise physically penetrating the a systemic HIV infection which could threaten their glove wall. When such objects are contaminated with employment in health care (See Orentlicher, D., 1991; an infectious pathogen, they can act as a carrier for the and New York Times article by Jane Gross, dated Aug. transfer of the infectious pathogen to the hand and the 18, 1991). Thus, there is a tendency for HIV infections hand wound. Alternatively, the glove wall puncture to go unreported by medical workers and this would may be caused in the absence of a solid physical object, suggest that data gathered to estimate the incidence of for example by any process that helps to cause a hole in accidental glove punctures among health care workers the glove. Processes that may help to cause a hole in a would be underestimated. glove include but are not limited to the following: a As mentioned, medical personnel work in environ chemical reaction with the glove wall material, a sol 45 ments having sharp medical instruments and needles vent dissolution of the glove wall, a change in the ambi which can readily puncture a standard medical glove on ent gas pressure or liquid pressure on a glove wall sur a hand and cause a hand wound (See Gerberding and face, passage of a powerful electrical shock through the Schecter, 1991). The reported incidence of accidental glove wall, a thermal melting or burning of the glove skin punctures to hospital surgical personnel in three wall, or a low temperature freezing followed by frag 50 major municipal hospitals (in San Francisco, Al mentation of the glove wall. In the forementioned ex buerque, and Atlanta) has averaged 2 to 5 injuries per amples, the process helping to or actually causing the 100 procedures (Panlilio et al., 1991; Gerberding et al., glove wall puncture may not actually transfer an infec 1990; Gerberding and Schecter, 1991). These hospitals tious pathogen to the hand or to the hand wound. In have also reported that occupational exposure to blood general a glove wall puncture always creates the access 55 occurs often in surgical settings (Gerberding et al., means through the glove wall for an infectious patho 1990; Gerberding and Schecter, 1991; Panlilio et al., gen from the exterior surface of the glove to then 1991). Accidental blood contact between a patient hav contact the hand or a hand wound. ing HIV and workers in other more casual (nonsurgical) Health care workers and medical doctors in particu medical settings has been predicted to increase in view lar, know that hand wounding is a common accident, of the epidemic spread of HIV infection in the United one that they often experience a number of times each States and in the World (Gerberding et al., 1990). year in their work environments because conventional Three known factors that can affect the risk of a medical gloves are not puncture-resistant and because medical worker becoming infected with an infectious this is a common risk in their work environments, par pathogen are (1) the prevalence of blood-borne infec ticularily with sharp objects (Panlilio et al., 1991; see 65 tion in the patient population under treatment by the especially Wright et al., 1991). For the present inven medical worker, (2) the frequency and types of hazard tion, the term "hand' is broadly defined to encompass ous exposure that the medical worker is subjected to, all portions of an arm and a hand that may be covered and (3) the risk of infection that accompanies each expo 5,357,636 10 Sure to the medical worker (Gerberding and Schecter, uid antiseptic composition capable of contacting and 1991). It is thought unlikely that medical personnel can coating the object puncturing the flexible glove; useful control the first two factors and still remain valid health as a treatment means for the hand and the hand wound care workers. It is one object of the present invention to that may occur when the flexible glove is punctured help to lower the worker's risk from the third factor, and/or the hand is wounded by the object puncturing namely a glove in accordance with the present inven the flexible glove; and particularily useful when the tion may be used to try to help to lower the risk of object may be contaminated with an infectious patho infection that accompanies each hazardous exposure to gen. a medical worker's hand. Related additional prior art is described below, but is The risk of systemic HIV infection to an individual 10 not identical to the present invention. In view of the wounded on a hand from a single hollow needle stick prior art, the subject matter of the present invention as has recently been estimated to average roughly 0.4 a whole would not be obvious to persons of ordinary percent (1 occurence in 250 events). This risk estimate skill in the art pertaining to the subject matter of the was calculated from observations of documented need present invention at the time of the invention. lestick wounds that were contaminated with blood from 15 A protective gel composition has been disclosed patients having an advanced stage of HIV infection (U.S. Pat. No. 5,019,604 issued May 28, 1990 to G. M. during which their blood had an elevated HIV titer Lemole) for coating the skin prior to covering the hands (Beckman et al., 1990; Henderson et al., 1990). This with standard surgical gloves. In one example, the com estimate is an underestimate because some hand injuries position contains lanolin, liquid silicone, polypropylene will not be reported and this study therefore under glycol monoleate, polytetrafluoroethylene powder in scores the real risk that medical workers experience. microspherical form, zinc oxide powder, anti-bacterial An analysis of the risk of infection that accompanies agents and antiviral agents with a preferred agent being each exposure of a hand and a hand wound to an infec nonoxynol-9. The composition forms a water repellent tious pathogen has been conducted, based upon an in coating on the skin to prevent the skin contacting body vitro study of glove wall punctures by needles. The 25 fluids such as blood and blood products that may pene study found that the risk was influenced by several trate the gloves and otherwise expose the skin to harm variables. An important variable was the volume of ful microbial and vital infections. The use of a protec infectious blood transferred by the needlestick (See tive gel to continuously contact the skin with chemicals Mast and Gerberding, 1991). Other important variables may be irritating to the hands. After glove removal, the included (1) the titer of the infectious pathogen in the 30 gel coating the skin must be washed off. Some individu contaminating blood, (2) the needle type and size, and als may also find that the number of steps required to (3) the depth of skin penetration by the pathogen con use and remove the gel is time consuming or disagree taminated object. Other observations have shown that able. Use of the gel composition between two gloves wearing a standard medical glove on the hand can re was not suggested. duce the volume of blood transferred to the hand 35 Use of antiseptic-coated gloves has been disclosed in wound by about 50 percent (See Gerberding and a study of surgical hand hygiene (J. Hospit. Infect. 1988, Schecter, 1991). When two pairs of standard medical 11 Supp. A:244-250 by Newsom et al.). Gloves were gloves were worn on the hand, the contamination of the coated with solid cetylpyridinium chloride and sur hand wound by blood was further reduced to between pressed skin flora counts after prolonged operations in 20 to 40 percent, (Gerberding and Schecter, 1991; Man comparison to standard gloves, but the solid antiseptic delbrot et al., 1990). Thus, studies have found that wear coating may cause hand irritation after prolonged ing two standard gloves on a hand can reduce, but does contact. Use of such antiseptic between two gloves was not adequately protect, a hand when it is wounded by a not suggested. blood-tainted needle. The hand can become contami Use of the antiseptic 4.0% chlorhexidine gluconate nated with a substantial fraction of the foreign blood, 45 detergent formulation containing 4.0% isopropyl alco infectious pathogens or other substances present on the hol (Hibiclens/Hibiscrub) and the antiseptic 0.50% glove-puncturing blood-tainted needle. In view of the chlorhexidine gluconate in 70.0% isopropyl alcohol (a) incomplete protection that conventional gloves can with emollients (Hibistat/Hibisol) as a skin treatment provide, (b) the frequency of accidental hand wounds has been disclosed (J. Hospital Infection, 1990, by gloved health care workers, and (c) the increasing SO 15:279-282 by Montefiori DC et al.). This antiseptic incidence of HIV infection in the human population, it composition was found to inactivate HIV in experimen is likely that the probability of a health care worker tal cell cultures after 15 seconds when used at 1:100 and becoming infected with HIV during work from HIV 1:5 dilutions. Use of such antiseptic between two gloves contamination of a hand wound will increase. The med was not suggested. ical profession is concerned about their risk of HIV 55 A sterile glove has been disclosed in which the anti infection from a medical glove puncture and would like bacterial agent zeolite is immobilized in a plastic film on their risk to be reduced (See Orentlicher, 1991). one or both surfaces of the glove; useful for handling To have medical utility, a protective medical glove food, for work in a kitchen or for medical purposes should retain the flexibility and the comfortability char (U.S. Pat. No. 5,003,638 issued Apr. 2, 1991 by T. acteristics of conventional medical gloves. The prior art Miyake and T. Yamamoto). According to the Merck has not disclosed a flexible protective medical glove Index (8th Edition), zeolite is a hydrated dust or pow having a wall that is capable of storing a non-liquid der of alkali aluminum silicate. An immobilized thin antiseptic composition which comprises an antiseptic. layer of antibacterial agent can not help to prevent a The prior art has not disclosed the uses for a flexible hand wound infection. protective medical barrier glove having a wall that 65 A glove has been disclosed which was made by first stores a non-liquid antiseptic composition which com immobilizing an anti-microbial agent into rubber and by prises an antiseptic. When a glove puncture is caused by then solidifying the mixture into a glove (U.S. Pat. No. an object, the present invention can provide a non-liq 5,031,245, issued Jul. 18, 1991 by Milner, R.). The glove 5,357,636 11 12 was reported to be an improved barrier to HIV. A at least an inner glove layer of a second material having non-ionic, sparingly water-soluble antimicrobial agent a thickness of between about 0.3 mils to about 30 mils that does not coagulate natural rubber latex such as wherein the first material and the second material form chlorophene, dichloroxylenol, hexachloraphane was at least the walls of a compartment storing a non-liquid used; diphenyl derivatives may be halogenated and used antiseptic composition or at least some of the material such as 0.1% to 10% by wt. 2,4,4'-trichloro-2'-hydrox components capable of comprising the non-liquid anti yphenyl ether, diacetylaminoazotoluene, triclocarban septic composition. The compartment(s) storing the and triclosan. The surface of the glove was dusted with non-liquid antiseptic composition, or its components in a powder containing an anti-microbial agent such as some separate fashion, may become mixed together to chlorhexidine digluconate and cyclodextrin. The anti O some degree during a glove wall puncture. Thus the septic dust on the glove surface contacts the hand while present invention has the capability to provide Some the glove is worn and may irritate the skin. non-liquid antiseptic composition in the compartment A multilaminar hybrid glove has been disclosed hav along at least some portion of the glove wall puncture. ing at least an outer rubber layer, an inner rubber layer As a result of a glove wall puncture a suitable amount of and at least one intermediate (cotton or Kevlar plastic) 5 the non-liquid antiseptic composition is formed. The material layer layer impregnated with a gel containing 4 compartment(s) generally has a thickness of less than percent nonoxynol-9; regions of the glove may be pro 100 mils; it is expected that the compartment(s) may tected with an armor of fungicide-coated, puncture become temporarily compressed during glove wear so resistant Kevlar plastic fabric (Infect. Control Hospital that compartment(s) thickness is capable of varying; in Epidemiol. 1991, 12(7): 435-438 by Johnson et al., 1991). 20 addition, the compartment(s) in some portions of the In vitro tests found that the glove with Kevlar resisted glove may be expanded due to glove design, or during some needlestick punctures. In vitro tests found that the the wearing of a glove to a thickness exceeding 500 glove reduced the transfer of HIV from a solid needle mils. At the back end of a glove where the hands are tip to a culture dish by chemical inactivation of the first inserted, the compartment(s) may be openior may virus on the needle when the needle contacted the gel 25 be closed. Alternatively, the glove compartment may containing nonoxynol-9 in the cotton layer. Results be optionally capable of being opened or closed using using "hollow” syringe needles were not obtained and for example a zip-lock sealing mechanism or other seal the authors indicated they could not predict such results ing seam mechanism, to allow the glove wearer to in without additional study. The authors disclosed that crease or reduce the amount of non-liquid antiseptic their gloves were too stiff and too thick-walled to func 30 composition in the glove. Preferably the compart tion on the dominant hand of a surgeon; they suggested ment(s) is closed. A glove in accordance with the pres that thinner, more surgically acceptable intermediate ent invention can be as flexible a conventional medical gloves were needed; but these three-layer gloves con glove; this is important because glove flexibility permits taining nonoxynol-9 gel antiseptic were not flexible a gloved hand to easily and adequately perform deli enough for the needs of a medical worker performing 35 cate, dexterous and complex hand work including for manual skilled work. example, the hand work of a surgeon, a medical doctor, The present invention is directed toward providing a dentist, a laboratory worker, a health care worker, a novel flexible protective medical glove designs and law enforcement worker, a hospital worker and like methods for their use. A glove in accordance with the workers. It is envisioned that the glove wall could be present invention can provide a non-liquid antiseptic constructed from almost any material or combination of composition treatment to a hand when the glove wall is materials provided that at least the surface of the inner punctured. The subject matter of the present invention glove layer and at least the surface of the outer glove as a whole has not been made obvious nor has it been layer are not liquid permeable. Most preferably at least suggested by the prior art for medical gloves or for the inner and the outer glove wall layers are made of antiseptic compositions used on the hands. The flexible 45 thin flexible layers of rubber and/or plastic materials. protective medical gloves comprising the present inven The non-liquid antiseptic composition comprises an tion are provide a major improvement in medical glove antiseptic in a non-liquid composition. Preferably the protection technology because the present invention antiseptic comprises at least one of the following anti may be useful as an automatic means for helping to septics: povidone-iodine, elemental iodine, sodium io protect a hand from becoming infected by a glove 50 dide, potassium iodide, sodium hypochlorite, nonox puncturing object when the object is contaminated with ynol-9, and chlorhexidine gluconate. For the present an infectious pathogen. Use of the gloves does not con invention the antiseptic composition is termed a "non stantly expose the hands to a potentially irritating anti liquid antiseptic composition' to distinguish its physical septic. The non-liquid antiseptic composition in the properties from the physical properties of a liquid anti gloves can not flow from a glove wall puncture as a 55 septic compositions. Once formed, the non-liquid anti liquid could. However, for some embodiments of the septic composition behaves as a non-liquid meaning that present invention the non-liquid antiseptic composition the complete antiseptic composition is incapable of may be capable of automatically expanding following a flowing like a liquid from a glove wall puncture. For glove wall puncture so that non-liquid antiseptic com the present invention, the term "non-liquid antiseptic position is expelled from the glove wall puncture onto composition' is not meant to imply that any of the the hand and into a hand wound should one occur. components which comprise the non-liquid antiseptic composition are necessarily non-liquid. Rather, the final SUMMARY OF THE INVENTION assembled or activated, non-liquid antiseptic composi It is an object of the present invention to provide a tion will have the inability to flow like a liquid. Thus, flexible protective medical glove having a thin flexible 65 one or more liquids may be used to form the non-liquid glove wall comprising at least an outer glove layer of a antiseptic composition, such as for example ethanol, first material having a thickness of between about 1 mil water, isopropanol, or a mixture thereof. Preferably the (1 milis one-thousandth of an inch) to about 40 mils and non-liquid antiseptic composition further includes at 5,357,636 13 14 least one surface active agent. The non-liquid antiseptic proteins may affect the binding of HIV to human cells. composition may also contain one or more of the fol Damage to these proteins by the non-liquid antiseptic lowing substances: an organic silicone, an organic sol composition may have anti-infective utility. Thus, the vent, a salt, an acid, a base, a pH buffer, a preservative term “infectious pathogen' for the present invention is that can help to stabilize the antiseptic activity, a metal broadly defined to include at least the following infec ion chelator, a catalyst, a sticky chemical additive, a tious pathogens in any of their physical forms: viruses, gelling agent, a thickening agent, a hardening or stiffen bacteria, yeasts, molds, algae, other fungi, multicellular ing agent, a humectant, an emulsifier, a viscosity-modi parasites, rickettsia, prions, the spores of infectious fying agent that may be used to increase the coating of pathogens, and includes any of the biochemical molecu the glove puncturing object by the the liquid antiseptic 10 lar fragments of an infectious pathogen (i.e., DNA, the composition, a chemical scent that can help to increase various RNA molecules, associated DNA and RNA the smell or render the odor of the liquid antiseptic enzymes and associated proteins) that could contribute composition more pleasant, a gas generation system, a to the infectivity of an infectious pathogen. For some foaming agent that can help to better mix the non-liquid embodiments of present invention, it is a preferred ob antiseptic composition with the contaminants on the ject that the non-liquid antiseptic composition has po hand and in the hand wound containing infectious tent antiviral or viricidal activity against the human pathogen, glycerin, a soap, a detergent, a pain-causing immunodeficiency virus (HIV), and/or the Hepatitis B agent (algesic), a coloring agent, and/or a vasocon WuS. stricting agent. An object of the present invention is to help to pro The present invention also provides a new method 20 tect the hand and a hand wound from becoming in for protecting a gloved hand from an infectious patho fected by a glove puncturing object that is contami gen in the event of glove damage while the glove is nated with an infectious pathogen should the object being worn. puncture the glove wall and contact or wound the It is another object of the present invention to also hand. When the glove wall is punctured by an object, provide methods for the use of the present invention. 25 the object may then wound the hand and come into Gloves in accordance with the present invention, like contact with the blood circulation of the individual. In standard medical gloves, can provide a useful thin phys passing through the glove wall, the object can become ical barrier form of protection to the hands. It is an coated with non-liquid antiseptic composition and can object of the present invention to minimize contact carry some non-liquid antiseptic composition along between the hand and the non-liquid antiseptic compo 30 with the infectious pathogen contamination that may be sition to reduce unnecessary irritation of the hand by present on the object, to the hand and into the hand the antiseptic, until such time that the wall of the glove wound; useful as a automatic and immediate non-liquid is punctured by an object, and then antiseptic is needed antiseptic composition treatment to the hand and the to contact the hand. For some embodiments of the pres hand wound that may help to immediately provide a ent invention, when an object punctures a glove wall of 35 protective treatment to the gloved individualso that the the invention, the present invention has the capability to individual does not acquire a systemic infection from automatically begin a non-liquid antiseptic composition the infectious pathogen on the glove-puncturing object. treatment of the hand or the hand wound should a In one embodiment according to the present inven wound occur. tion, the glove is comprised of a liquid-impermeable The treatment of non-liquid antiseptic composition outer layer of a first material and a liquid-impermeable from the glove should be capable of inactivating, kill inner glove layer of a second material wherein the first ing, and/or otherwise destroying the infectious patho material and the second material form the walls of a gen that the non-liquid antiseptic composition may compartment(s) capable of containing a non-liquid anti contact. The non-liquid antiseptic composition should septic composition; the compartment(s) contain or may be capable of disabling the contacted infectious patho 45 store the non-liquid antiseptic composition. The glove gen so that the infectious pathogen from the object is no also has the capability to provide a coating to at least a longer a danger to the hand and the hand wound of the portion of the object puncturing the glove wall; the contaminated individual. For the present invention, the coating comprising the non-liquid antiseptic composi term "infectious pathogan' has a broad meaning in tion; the coating on the object providing a means for tended to encompass known and to be discovered 50 automatically and immediately transfering some of the pathogenic microorganisms which would include pri non-liquid antiseptic composition onto the hand and ons and viruses as well as the biochemical cofactors or into the hand wound resulting from the object punctur molecular fragments that can be synthesized or released ing the glove while the glove is being worn; the non-liq by an infectious pathogen or by other biological cells or uid antiseptic composition transferred to the hand and that may arise by other biosynthetic means that could be 55 the hand wound having the capability to provide a considered to be infective; the term is intended to in treatment of non-liquid antiseptic composition to the clude biochemical cofactors and chemical fragments hand and the hand wound which may have become including but not limited to the following examples of contaminated with an infectious pathogen transferred infective materials as well as their related biochemical from the glove-puncturing object. It is desirable that the machinery: deoxyribonucleic acids (DNA), ribonucleic 60 non-liquid antiseptic composition have some capability acids (RNA, mRNA, tRNA and the like), protein co to dissolve into or become liquified upon contact with factors, and the enzymes that act upon DNA, RNA, the hand or upon contact with the glove-puncturing mRNA, tRNA and like nucleic acids in any form or object or upon contact with hand fluids or blood of the conformation which may alter the potency of a patho hand wound due. The glove has the additional capabil genic infection. The non-human proteins that help HIV ity of treating the hand and the hand wound with the to inhibit the human immune system are considered for non-liquid antiseptic composition when the object the present invention to be protein cofactors and are punctures the glove wall, when the object contacts the considered relevant infective materials. Some of these hand, if and when the object wounds the hand and 5,357,636 15 16 whether or not the object actually contaminates the agent is to reduce blood flow in the hand wound area as hand and the hand wound with the infectious pathogen. a means for limiting the systemic dispersion of the infec The non-liquid antiseptic composition automatically tious pathogen away from the hand wound by the blood and immediately transferred by the glove-puncturing circulation or by the lymphatic circulation of the indi object from the glove to the hand and the wound on the vidual. hand, may be useful by beginning to help to protect the According to another embodiment of the present hand, the hand wound, and thus the systemic circula invention, the glove contains a non-liquid antiseptic tion of an individual by killing, inactivating and/or composition which may also contain a viscosity-nodi otherwise destroying without undue delay the infec fying agent that can be used to alter the physical proper tious pathogen that may have contaminated the hand 10 ties of the liquid antiseptic composition; this additive and the hand wound as a result of a glove-puncture by can be particularly useful as a means for influencing the an object that may be contaminated with an infectious thickness of the coating of non-liquid antiseptic compo pathogen. sition that can form on the object that punctures the In a second embodiment according to the present glove wall. invention, the glove can provide a non-liquid antiseptic 15 According to another embodiment of the present composition such as a foam, a paste, a gel, an ointment invention, the non-liquid antiseptic composition may or other greasy composition which is capable of option have adhesive properties that allow the non-liquid anti ally being redistributed within the compartment(s) of septic composition to coat or "gum-up' the surfaces of the glove by the manual application of pressure to the the object that contact the composition as the object glove wall compartment(s) in order to force the non-liq 20 punctures the glove;useful so that the contamination uid antiseptic composition in the compartment(s) to including infectious pathogen on the object is less accumulate near the glove wall having the hole should readily spread from the glove-puncturing object when one becaused by a glove-puncturing object. As a result, the object contacts the hand or causes a hand wound. the non-liquid antiseptic compostion can then option According to another embodiment of the present ally be forcibly extruded from the punctured glove wall 25 invention the glove wall has a plurality of glove layers having the hole onto the hand and into the hand wound; that can act as a structural connection which reconfig the additional non-liquid antiseptic composition con ures the compartment storing the non-liquid antiseptic tacting the hand and the hand wound may be used to composition into a plurality of compartments capable of help to provide additional protection to the hand, the storing the non-liquid antiseptic composition; useful as a hand wound, and the systemic circulation of an individ 30 means for selectively partitioning the non-liquid anti ual from an infectious pathogen that may have contami septic composition in the glove wall. nated the hand and the hand wound when the glove According to another embodiment of the present puncturing object contacted the hand and caused a invention, the glove wall comprises a sponge-like wall hand wound. A hand wound is defined for the present structure capable of acting as a structural connection invention as at least a degree of damage to the skin that 35 which reconfigures the compartment storing the non increases the probability that an individual can become liquid antiseptic composition into a plurality of com infected by an infectious pathogen. A hand wound may partments capable of storing the non-liquid antiseptic or may not cause bleeding of body fluids or blood from composition; the outer and inner surfaces of the glove the individual. wall can be coated with a liquid-impermeable coating of In another embodiment according to the present in a rubber or a plastic material. The actual number of vention, the glove contains a non-liquid antiseptic com pore-sized compartments, the degree of segmentation of position which may also contain a pain-causing chemi the glove wall into the compartments, and the volume cal (algesic agent) such as a potassium salt, formic acid, of each subcompartment are not critical limitations for bradykinin or substance P. One object of the pain-caus the present invention and may be highly variable. ing chemical is to provide enhanced pain sensation at 45 According to another embodiment of the present the hand wound to better warn the glove wearer that invention, the compartment storing the non-liquid anti they may have suffered a hand wound. septic composition is subdivided into a number of According to another embodiment of the present smaller compartments as a means for controlling the invention, the glove contains a non-liquid antiseptic distribution and capacity for redistribution of the non composition which may also contain a colored sub 50 liquid antiseptic composition within the glove wall. stance such as a dye or an opacifier that can help to Each smaller compartment may be connected to an visually signal when and where a glove wall has been other small compartment by at least one hole so that the punctured or damaged; useful particularily for dis non-liquid antiseptic composition can be dispersed be tracted, preoccupied, or overly-stressed individuals tween the compartments if desired using a pressure needing to wear a medical glove. 55 gradient. Some of the subdivided compartments may be According to another embodiment of the present closed. invention, the glove contains a non-liquid antiseptic According to another embodiment of the present composition which may also contain a chemical capable invention, the compartment storing the non-liquid anti of producing a distinctive chemical smell or odor which septic composition is subdivided into a plurality of can be either bad smelling or pleasant smelling. A Sud closed compartments as a means for controlling the den release of the distinctive chemical odor from a distribution or thickness of the non-liquid antiseptic glove puncture can be a useful means for increasing a composition within the glove wall. glove wearer's awareness that a glove may be damaged. According to another embodiment of the present According to another embodiment of the present invention, the compartment of the glove storing the invention, the glove contains a non-liquid antiseptic 65 non-liquid antiseptic composition is connected to an composition which may also contain a vasoconstricting additional compartment of non-liquid antiseptic compo agent; preferably a catecholamine such as epinephrine sition using a tube with an opening whose aperature can or norepinephrine. An object of the vasoconstricting be varied as desired or closed entirely. 5,357,636 17 18 The subject matter which we regard as our invention glove is being worn when the wall of the glove is punc is more particularily pointed out and distinctly claimed tured and/or when the hand is wounded by an object in the concluding portion of this specification. Other that may be contaminated with an infectious pathogen. features and advantages are inherent in the protective It is an object of the present invention to provide a glove and method claimed and disclosed for its use or 5 glove having any conceivable arm length, up to and will become apparent to those skilled in the art from the including a glove having an arm length that can protect following detailed description in conjunction with the the entire arm of an individual up to about the shoulder accompanying diagrammatic drawings. region of the individual. Whereas the normal length of the glove is between about 8 inches and about 12 inches, BRIEF DESCRIPTION OF THE DRAWINGS O FIG. 1A is a perspective view and a partial enlarged the arm-length long glove may be up to 36 inches in view illustrating a glove containing a non-liquid anti length. septic composition between an outer layer of a first A glove in accordance with the present invention can material and the inner layer of a second material in have elastic walls so that one size of the glove may be accordance with the present invention; 15 worn on several different sized hands as can a conven FIG. 1B is a partial enlarged view of the section of a tional medical examination glove. Alternatively, a glove wall shown circled in FIG. 1A: glove in accordance with the present invention can be FIG. 2A is an enlarged sectional view of a glove wall made available in a number of different sizes as are some taken along line 5-5 in FIG. 1A, illustrating one edge conventional medical surgical gloves, so that the glove of an object which is puncturing a glove in accordance 20 does not need to be substantially stretched or unduly with the present invention; in this example, the object is stressed by the glove wearer in order for the glove to puncturing the glove wall along line 5-5 and the non closely fit their hand. liquid antiseptic composition in the glove wall is in the FIG. 1B is an enlarged view of a representative sec process of coating the object; tion of the glove wall shown circled in FIG. 1A. FIG. FIG. 2B illustrates the situation of FIG. 2A at a later 25 1B illustrates that the glove wall comprises an outer point in time, after a portion of the glove-puncturing layer 2 of a first material and an inner layer 3 of a second object has fully punctured the glove wall and has then material. Together the first material and the second wounded the hand; in the process the non-liquid anti material can be used to form the walls of a compartment Septic composition coating or smearing on the glove 4 that is capable of containing or storing a non-liquid puncturing the object has been transferred to the hand 30 antiseptic composition. and hand wound as an immediate automatic antiseptic A glove in accordance with the present invention treatment to the hand and to the hand wound; and contains or is capable of containing a non-liquid antisep FIG. 2C illustrates the situation of FIG. 2B at a later tic composition in compartment 4. Not depicted in the point in time, following either the optional application figures is the feature that compartment 4 for some em of external manual pressure to the damaged glove or for 35 bodiments of the present invention can optionally be some embodiments of the present invention after glove configured into any shape or size within reasonable damage has occurred and initiated internal gas produc limits of utility. Furthermore, compartment 4 may be tion by the non-liquid antiseptic composition and cre subdivided into a plurality of compartments; each of ated an internal positive pressure within the compart these may be termed a subcompartment for the present ment that can expand or expell some forms of the non- 40 invention. A variety of open, porous, partly closed, liquid antiseptic composition from the glove out of the and/or closed additional partitions or walls within the hole caused by the glove-puncturing object; the resultis compartment may be used to form the subcompart both useful for increasing the amount of non-liquid ments. The non-liquid antiseptic composition is symbol antiseptic composition in the glove wall near the glove ized in all figures by stippling the area in the figure with puncture hole, and is useful for extruding or expelling a 45 dots. The non-liquid antiseptic composition comprises suitable amount of non-liquid antiseptic composition an antiseptic in a non-liquid composition. For some from the glove wall through the glove wall puncture embodiments of the present invention, the antiseptic hole and onto the hand and into the hand wound; may be used in a solid form and may be the only ingredi FIG. 3 illustrates a perspective view of a glove in ent comprising the non-liquid antiseptic composition. accordance with the present invention, and a partial 50 For example, a powder of sodium iodide or potassium expanded view of a finger and a partial expanded view permanganate might be used as a non-liquid antiseptic of the wrist area; the compartment storing non-liquid composition. antiseptic composition is enlarged in the wrist area of It is another object of the present invention to pro the glove; vide a flexible glove wall capable of providing a physi FIG. 4 illustrates a perspective view of a glove in 55 cal barrier means of protecting the hand while the glove accordance with the present invention with a partial is being worn by an individual. The glove can provide expanded view of the glove wall; the glove has several a useful physical barrier until a portion of the glove wall structural connections between the innner layer and the is punctured by an object. When a glove in accordance outer layer of the glove. with the present invention is to be worn on the hand of 60 a person such as a surgeon, a medical doctor, health DETALED DESCRIPTION OF THE care worker, or other worker, the glove wall needs to INVENTION be flexible so that the the gloved hand can easily and FIG. 1A illustrates a glove in accordance with the adequately perform delicate, dexterous and complex present invention; the glove indicated generally at 1 is work without causing the hand to become tired. composed of flexible materials forming a liquid- 65 It is another object of the present invention to pro impermeable wall having the capability to provide a vide the method of using a flexible protective medical non-liquid antiseptic composition treatment to a hand glove in accordance with the present invention wall on and to a hand wound underneath the glove while the a hand of an individual to protect the hand in the event 5,357,636 19 that an object that may be contaminated with an infec However, a sharp object is depicted here only for illus tious agent punctures the glove, comprising the steps of: trative purposes and is not meant to be a limiting exam (a) using the glove initially as a liquid-impermeable ple. The glove puncturing object may be a blunt-edged physical barrier to infectious pathogens; during which object. For any glove-puncturing object, the interac the glove can be used to permit the hand to perform a 5 tions between glove-puncturing object 6, glove layer 2, delicate, dexterous and complex type of work that in glove layer 3, non-liquid antiseptic composition 4 and cludes the type of work performed by a surgeon, a hand 8 as illustrated in the figures, are expected to be medical doctor, a dentist, a laboratory worker, a hospi similar as will become readily apparent from the follow tal health care worker, a law enforcement worker, and ing detailed description of these interactions. a hospital worker; and during which the glove can be 10 FIG. 2A illustrates a cross-section of a glove wall used to store a non-liquid antiseptic composition in the along Line 5-5 as shown in FIG. 1A. A glove-punctur glove wall; ing object 6 is shown puncturing a glove on a hand 8 at (b) using the glove to coat a portion of an object that a glove wall puncture 10. Object 6 may be contami may puncture the glove wall with the non-liquid anti nated with an infectious pathogen. In addition, object 6 septic composition while the object punctures the com 15 may be contaminated with blood, other body fluids, partment in the glove storing the non-liquid antiseptic other solids and mixtures therof. The contamination of composition; the glove-puncturing object 6 has not been depicted in (c) using the object puncturing the glove to transfer a these figures. The three arrows in FIG. 2A indicate the portion of the non-liquid antiseptic composition coating direction of motion for object 6. The contact angle of the object from the glove to the hand and into the hand 20 object 6 with the glove wall is not critical for function wound; and of the present invention. (d) using the non-liquid antiseptic composition that is It is another object of the present invention to pro transferred to the hand and into the hand wound to help vide a coating 7 of non-liquid antiseptic composition on to kill, inactivate, and to otherwise destroy any infec the puncturing portion of object 6. When object 6 punc tious pathogen transferred to the skin and into the hand 25 tures outer glove layer 2 and contacts compartment 4 wound by the glove-puncturing object. storing the non-liquid antiseptic composition, the It is another object of the present invention to pro contact may provide object 6 with a coating 7 of non vide a flexible protective medical glove that can be liquid antiseptic composition. worn to protect an individual from an infectious patho It is another object of the present invention to trans gen; such a glove is particularily useful for a worker 30 fer a portion of coating 7 from object 6 for example, to who ordinarily needs to wear a pair of standard medical the space between inner glove layer 3 and hand 8. In or standard surgical gloves in order to protect their FIG. 2B, object 6 is puncturing inner glove layer 3 and hands during their work. Gloves in accordance with the thus has completely punctured the glove wall. If the present invention can provide antiseptic chemical pro non-liquid antiseptic composition is an essentially dry tection in addition to the barrier protection provided by 35 solid, a granular, a crystalline, a powder or the like dry conventional medical gloves. Thus, the present inven composition, then coating 7 of non-liquid antiseptic tion should be useful for medical personnel such as composition on object 6 may deposit some of the dry doctors, surgeons, dentists, laboratory workers, health composition in a small portion of the space between care workers, and other hospital workers; the gloves inner glove layer 3 and hand 8. Fluid matter on object should be particularily useful for medical personnel and 6 may cause the dry non-liquid antiseptic composition other individuals who care for or may come into poten to adhere to some degree on object 6. If the non-liquid tially infectious contact with AIDS infected or Hepati antiseptic composition contains in part some liquid and tis B infected patients. /or the antiseptic is solvated to some extent, as occurs FIG. 2A, FIG. 2B, and FIG. 2C illustrate the func with a number of non-liquid compositions such as tion of the present invention when an object causes a 45 foams, pastes, gels, ointments, greases, bases and the like glove puncture while the glove is being worn on a hand. compositions, then coating 7 is more likely to smear, In most instances, a glove in accordance with the pres stick, film or provide an even or more complete coating ent invention is thin-walled like a standard medical on the puncturing surfaces of object 6; preferable as a examination glove or like a standard surgical glove. means for allowing a portion of the non-liquid antiseptic Thus, a glove wall of the present invention is capable of 50 composition to be transferred on object 6 from com being punctured by an object when it contacts the glove partment 4 to the space between inner glove layer 3 and wall with sufficient force. For the present invention, the hand 8. definition of a glove-puncturing object is meant to in It is another object of the present invention to have clude objects capable of puncturing, tearing, penetrat the capability to transfer a portion of coating 7 to hand ing, cutting, abrading, shredding, chopping, biting, or 55 wound 9, should a hand wound occur when the glove is otherwise disrupting the physical integrity of the glove punctured by object 8. Depending upon the depth of wall. The wounding of a gloved hand is a common penetration of object 6 into hand 8, the hand wound 9 accident with health care workers. The glove punctur may have a shallow or a deep depth and variable bleed ing object may be blunt or sharp edged. Typical objects ing. Prior to contacting the gloved hand, object 6 may that may cause an accidental glove puncture include the 60 have been contaminated; the contamination may in following objects: hypodermic syringe needles, suture clude an infectious pathogen, blood, other body fluids, needles, other needles, glass fragments, sharp metal other solids and mixtures thereof. The infectious patho fragments, scapel blades, mechanical devices, surgical gens transferred from object 6 to hand 8 or hand wound instruments, medical instruments, blunt forceps, glass 9 can cause a hand infection and/or a systemic infection slides, glass capillary tubes, and accessory medical ob 65 in a human. As mentioned above, it is known that the jects such drill tips, chisels, saws, wires and other glass risk of an infection in the gloved individual may be objects. The edge of the glove-puncturing object de significantly lowered by immediately treating the po picted in FIG. 2A, FIG. 2B, and FIG. 2C is sharp. tentially contaminated hand and the hand wound with 5,357,636 21 22 an antiseptic. If object 6 contamination includes HIV effective disinfection by inactivating, killing and/or virus or Hepatitis B virus, then contamination of hand 8 otherwise destroying any infectious pathogen trans or hand wound 9 by object 6 can be very dangerous. ferred to the hand wound. Thus, use of gloves in accor Thus, a particularily important capability of a glove in dance with the present invention is envisioned as a par accordance with present invention is to use the glove ticularily important preventative measure when there is puncturing object 6 to transfer some of the non-liquid any anticipated risk that the glove wearer could become antiseptic composition from the glove to the hand and exposed through the hands to HIV hepatitis B virus. into hand wound as a preventative antiseptic treatment For some embodiments of the present invention the at the same time that object 6 may be contaminating the glove may be designed so that the non-liquid antiseptic hand and a hand wound with an infectious pathogen. O composition in compartment 4 is capable of some redis Providing an immediate treatment of non-liquid antisep tribution. Providing the present invention with the ca tic composition to the hand and to the hand wound may pability for some redistribution of the non-liquid anti be critical to help to prevent the establishment of a septic composition may help meet the needs of the pathogenic systemic infection in individuals. glove wearer following an accidental glove wall punc It is another object of the present invention as illus 15 ture. When the risk of infectious pathogen contamina trated in FIG. 2C, to optionally enable the glove wearer tion to hand 8 and hand wound 9 has been perceived, or any other individual observing the gloved hand to then reflex glove massage by the gloved individual may more quickly see puncture site 10. To accomplish this be a particularily effective method of using a glove in objective, the non-liquid antiseptic composition may accordance with the present invention to mobilize addi contain a colorant. The colorant may consist of one or 20 tional non-liquid antiseptic composition onto the hand more dyes and/or one or more opacifiers or any combi and into the hand wound where it can be useful. Option nation therein. Some examples of the colorants that may ally, the glove wearer can massage (rub or apply con be used in the liquid antiseptic composition include but stant pressure) to the glove wall near the puncture are not limited to one or a combination of the more than wound to force the non-liquid antiseptic composition in one of the following dyes: FD&C Yellow No. 5, FD&C 25 compartment 4 to accumulate near the glove wall hav Yellow No. 6, D&C Yellow No. 10, FD&C Red No. 40, ing the hole (the hole in glove wall puncture 10). The FD&C Red No. 40, D&C Red No. 28, D&C Red No. thickness of compartment 4 in the glove wall in FIG. 30, D&C Red No. 33, FD&C Blue No. 1, FD&C Blue 2C is expanded compared to its thickness in FIG.2B to No. 2., FD&C Green No. 3, D&C Green No. 5, yellow illustrate the point that a local accumulation of the non iron oxide, black iron oxide, red iron oxide brown iron 30 liquid antiseptic composition may occur in compart oxide and mixtures thereof. Any suitable dye may be ment 4 near glove wall puncture 10 as a result of glove used. The colorant may be combined with one or more massage. The local accumulation of non-liquid antisep of the following opacifiers: white titanium dioxide, tic composition in the glove wall can be further mas white calcium carbonate, white zinc sulfate, white zinc saged or pressured by a hand or other means to force oxide, yellow iron oxide, black iron oxide red iron oxide 35 the non-liquid antiseptic composition in compartment 4 brown iron oxide and mixtures thereof. Other accept to become expelled, moved or extruded from the punc able opacifiers may be used. ture hole in the glove, onto the hand and into the hand Optionally, after a glove has been punctured by an wound. This redistribution of the non-liquid antiseptic object, another object of the present invention is to composition is only feasible when for example the non provide a smaller hole in outer glove layer 2 than in liquid antiseptic composition is in a distensible or mold inner glove layer 3, after the glove-puncturing object able state such as a foam, gel, paste, ointment, grease, has been removed from the glove wall at puncture 10. putty, base and the like combinations of gas, liquid, The relatively larger hole in inner glove layer 3 can and/or solids. help to promote a relatively larger transfer of non-liquid For some embodiments of the present invention, the antiseptic composition from the glove to the hand and 45 non-liquid antiseptic compositions may be capable of hand wound than from the glove to the outer surface of providing a gas with antiseptic properties; examples of the glove wall. In other words, the difference in outer such antiseptic gases include but are not limited to the and inner glove layer puncture holes may be used to following gases: oxygen, chlorine, fluorine, bromine, direct the non-liquid antiseptic composition toward the iodine, chlorine dioxide, ozone, other halogen-oxygen hand where it is needed to provide a treatment and may SO compound gases, aldehyde gases, ethylene oxide, prop help reduce antiseptic contamination of the external ylene oxide, propiolactone, sulfur, and the like and mix surface of the glove. External antiseptic contamination tures thereof. The antiseptic gas may be formed before, of a doctor's gloves may be undesirable for example during or after the act of glove puncture by an object, around medical patients or for a surgeon during internal or for example at the discretion of the glove wearer. surgery when the internal tissues of patient's body 55 The gas may be formed or provided by from the combi should not be exposed to an antiseptic. nation and/or chemical reaction and/or decomposition Whether or not the glove-puncturing object is known of a substance or substances(s) present in compartment to be contaminated with an infectious pathogen, it is 4 which may be singular or multicompartmental. Gas another object of the present invention to provide a producing substances may readily diffuse to the hand prophylactic treatment of non-liquid antiseptic compo and hand wound treatment area through the glove sition to the hand and to the hand wound when a glove puncture hole caused by the glove-puncturing object. wall puncture 10 is caused by any object. The non-liq For some embodiments of the present invention, a uid antiseptic composition transferred to the hand and dry solid antiseptic composition may be provided in the hand wound can contact the hand and can dissolve compartment 4. Effective massage and/or redistribu or liquify in the hand wound. An immediate and non 65 tion of a dry solid antiseptic composition in compart delayed mixing of the antiseptic composition with any ment 4 may be difficult. biological or infectious pathogen contamination that It is envisioned that for some embodiments of the may be present in hand wound 9 may be useful for present invention, a combination of substances in the 5,357,636 23 24 glove or at the treatment area(s) may provide during the case-hardened rubber, another butadiene rubber, a use of the present invention suitable antiseptic gases cross-linked rubber, isobutylene-isoprene 1. butyl rub and/or non-liquid antiseptic compositions that are capa ber, butadieneacrylonitrile 1. nitrile rubber, styrene ble of being dispersed from the glove puncture. Disper butadiene rubber, ethylene-propylene copolymer, ethy sion may be accomplished by glove massage or other 5 lene-propylene diene terpolymer, polyisobutylene, manually applied pressure or chemical generation of chlorosulphonated polyeten, ester-type urethan rubber, pressure and/or expanding antiseptic composition vol Polychlormethyloxyran epichlorhydrin rubber, epi ume within compartment 4 may expell the non-liquid chlorhydrin copolymer with ethyleneoxydichlorme antiseptic composition from the glove wall puncture to thyloxyran copolymer, another suitable rubber and the hand to inactivate or kill infectious pathogens that 10 mixtures thereof; and optionally a colorant selected may be present on the hand or in the hand wound or from the group consisting of titanium oxide, an iron other treatment areas. Treatment areas include but are oxide, a dye and mixtures thereof. The second material not limited to the following: any surfaces of the glove (used for the inner glove layer) may comprise: a plastic puncturing object including the inner barrel of the sy structural material selected from the group consisting of ringe needle, any surfaces of the glove and/or its com- 15 cellulose acetate plastic, vinyl plastic, polyethylene partment(s), and any portions of the hand(s) and/or any plastic, polypropylene plastic, polyvinyl chloride plas hand wounds that may be present or may form while a tic, polyvinyl acetate plastic, polystyrene plastic, poly glove in accordance with the present invention is being methyl methylacrylate plastic, polyacrylonitrile plastic, worn by an individual. vinyllite plastic, saran plastic, polytetrafluoroethylene To make a glove in accordance with the present 20 plastic, polycaprolactam plastic, polytrifluorochloro invention which has an outer glove layer and an inner ethylene plastic, nylon plastic, rayon plastic, polyester glove layer of similar elasticity and similar plasticity, plastic, urea formaldehyde plastic, polyurethane plastic, similar materials forming these glove layers may be isotactic polypropylene plastic, polyamide plastic, phe used and may comprise: (a) a structural material se nolic plastic, silicone plastic, another suitable plastic, lected from the group consisting of latex rubber, cis-1,4- 25 silk fiber, another suitable fiber from an animal secre polyisoprene, cis-polybutadiene, neoprene rubber, ni tion, cotton fiber, another suitable plant fiber, wool trile rubber, silicone rubber, polychloroprene rubber, fiber, another suitable animal fiber, animal hair, animal another halogenated rubber, a case-hardened rubber, skin, animal intestinal and connective tissues, metallic another butadiene rubber, a cross-linked rubber, isobu fiber, mineral fiber, chemically-modified natural fibers, tylene-isoprene 1. butyl rubber, butadiene-acrylonitrile 30 chemical-modified synthetic fibers another synthetic 1. nitrile rubber, styrene-butadiene rubber, ethylene fiber, and mixtures thereof; and a colorant selected from propylene copolymer, ethylene-propylene diene ter the group consisting of titanium oxide, an iron oxide, a polymer, polyisobutylene, chlorosulphonated polyeten, dye and mixtures thereof. Materials obtained from ani ester-type urethan rubber, polychlormethyloxyran epi mal intestinal tissues and animal connective tissue may chlorhydrin rubber, epichlorhydrin copolymer with 35 comprise the intestinal wall, ligaments, tendons and ethyleneoxydichlormethyloxyran copolymer, another fascia and like tissue obtained from slaughtered farm or suitable rubber, cellulose acetate plastic, vinyl plastic, ranch animals including the following animals: cow, polyethylene plastic, polypropylene plastic, polyvinyl bull, sheep, steer, horse, chicken, goat, mink, rabbit, and chloride plastic, polyvinyl acetate plastic, polystyrene pig. It is imagined that almost any animal may provide plastic, polymethyl methyl-acrylate plastic, polyacrylo- 40 suitable raw materials for the glove. nitrile plastic, vinyllite plastic, saran plastic, polytetra Optionally the colorants may be homogeneously fluoroethylene plastic, polytrifluoro-chloroethylene mixed with the glove wall structural materials to color plastic, polycaprolactam plastic, polyester plastic, urea the materials and/or to opacify the materials. Alterna formaldehyde plastic, polyurethane plastic, isotactic tively, optionally one or more colorants or opacifiers polypropylene plastic, nylon plastic, rayon plastic, 45 and mixtures thereof may be printed onto the glove wall polyamide plastic, phenolic plastic, silicone plastic, or may color the wall with a design or pattern or car another suitable plastic, silk fiber, suitable fiber from an toon figure that renders the glove wall opaque or col animal secretion, cotton fiber, cellulose fiber, another ored in a more pleasing or useful decoration. The design suitable plant fiber, wool fiber, another suitable animal or pattern may have an appealing look or look non fiber, animal hair, animal skin, animal intestinal tissue, 50 threatening to help the patient of the glove wearer, or animal connective tissue, another suitable animal tissue, glove wearer feel less anxious, less frightened, and metal fiber, mineral fiber, another suitable synthetic amused or calmed; this optional visual effect of the fiber, and mixtures thereof; and (b) optionally a colorant present invention is particularily useful for calming selected from the group consisting of titanium oxide, an children and nervous or frightened patients of a gloved iron oxide, a dye and mixtures thereof. If structural 55 medical doctor or other health care worker. Such col materials are used that can form liquid permeable lay oration may also be useful in general when gloves are ers, then the wall structure may be coated or embedded worn by other individuals who may come into contact with a liquid-impermeable material to make the glove with other individuals, or who may be engaged in dis structure layer liquid-impermeable. tasteful work activities requiring glove wear. The de Alternatively, to make a glove in accordance with 60 sign on the gloves may in addition have a positive in the present invention having an inner glove layer of pact on the glove wearer or provide written instruc lower elasticity and higher plasticity than the outer tions or reminders to a gloved worker of a procedure glove layer, the first material (which is used for the for example. Glove coloration or opacity can also be outer glove layer) may comprise an elastic structural used to make a glove in accordance with the present material selected from the group consisting of latex 65 invention have the coloration appearance of a conven rubber, cis-1,4-polyisoprene rubber, cis-polybutadiene tional medical glove. For example, the coloration and rubber, neoprene rubber, nitrile rubber, silicone rubber, /or opacification of the glove wall can be used to ob polychloroprene rubber, another halogenated rubber, a scure the presence of the non-liquid antiseptic composi 5,357,636 25 26 tion contained within a thin-walled glove of the present Absorption bases are hydrophilic and may be com invention. prised of lanolin and petrolatum and/or animal sterols A glove in accordance with the present invention can (for example cholesterol, oxycholesterol and/or other contain a non-liquid antiseptic composition, or is suit suitable wool fat fractions) and petrolatum. The stiff ably capable of providing an antiseptic in a non-liquid ness and thermal stability of an absorption base can be composition as the glove is punctured by an object. The increased by the inclusion of waxes, stearyl alcohol and then-formed non-liquid antiseptic composition is not like substances. Wool alcohols can be prepared by treat capable of flowing like a liquid from compartment 4 ing wool fat with alkali and separating the fraction from the glove puncture hole. However, the contact containing cholesterol and other alcohols. A base made between the non-liquid antiseptic composition and (1) a O with wool alcohol and wax easily absorbs water and hand, (2) a glove-puncturing object, and/or (3) an arti this hydrophilicity may enhance the antiseptic activity ficial or biological substance in or from the hand wound of antiseptic(s) used in absorption bases. The addition of may cause an alteration(s) in the non-liquid state of the water to an absorption base may improve the bases's non-liquid antiseptic composition. After contact, the emolliency (softness). non-liquid antiseptic composition may become capable 15 Emulsion bases are solid emulsions to which it is of liquifying or softening to the extent that the composi possible to incorporate additional water. Optionally, the tion or the new mixture following contact which in emulsion base may contain wetting agents, dispersing cludes the non-liquid antiseptic composition might then agents, emulsifiers, penetrants, emollients, humectants, have the capability to flow like a liquid or the non-liquid detergents, hardeners, preservatives and the like to antiseptic composition may dissolve in blood or other 20 modify the properties of the base. Surface active agents biological liquid. The dissolution may be useful for may, for example, be ionic (cationic or anionic com improving contact between the antiseptic and infectious pounds, for example soaps), zwitterionic, polyionic, or pathogens. nonionic surface active agents which contain hydroxy The non-liquid antiseptic composition comprises one groups and ether linkages (polyhydric alcohol anhy or more antiseptics in a non-liquid composition. As 25 drides and polyoxyethylene chains) to provide hydro mentioned previously, the non-liquid antiseptic compo phillic activity. For example, polyoxyethylene glycol sition may contain one or several liquid substances as 400 (PEG 400), a Tween, Span 40, Polysorbate 80, components in the composition. The liquid(s) provided polyoxyl 40 stearate, and the like are frequently used in the composition may have a number of functions for examples of nonionic surface active agents. Water solu some embodiments of the present invention including 30 ble ointment bases may comprise an aqueous phase of 10 an antiseptic function, or a solvent or a dispersant func to 80 percent, an emulsifying agent, and an oleaginous tion useful during preparation of the non-liquid antisep phase of 20 to 90 percent. A humectant, for example, tic composition or during use of the present invention. glycerin, propylene glycol, or a polyethylene glycol Low molecular weight liquids are particularily useful may be added to the aqueous phase to stabilize the during the formation of the composition to help to sol 35 water content of the ointment base. The humectant can vate and to properly disperse/mix the colloids and poly also improve the dispersion of the non-liquid antiseptic mers added to form the non-liquid antiseptic composi composition when it comes into contact with aqueous tion. media on the hand and in the hand wound (such as for For the present invention, the non-liquid antiseptic example sweat, serum, and blood) should a wound oc composition may take on one or more of the following cur. The addition of certain alcohols, for example stea forms during the use of the present invention: a foam, a ryl alcohol, cetyl alcohol, fatty acid esters of sorbitan or gel, a paste, a magma, an ointment, a gas, a solid, a mannitan, alkyl alcohols (C20-C30) can be added to microscopic dust, a powder, as crystalline powder, an emulsion base formulas to help to stabilize the aqueous aerosol, a non-liquid emulsion, a multiple phase emul content of the emulsion. Stearyl alcohol is a solid that sion, a base including the following conventional der 45 also contributes to the hardness of the ointment base. matological bases (an oleaginous ointment base, an ab The oleaginous phase (also known as the non-aqueous sorption ointment base, an emulsion ointment base, and phase) may comprise a petrolatum, fats, waxes, organic a water-soluble ointment base), a grease, a putty, a non alcohols, polyglycol esters, and the like water-insoluble flowable cream, and the like other soft, deformable molecules. The emulsifier for an oil-in-water emulsion gas/liquid/solid combination formulations. 50 may be an alkali soap, alkyl sulfate, amine soap, poly The non-liquid antiseptic composition has the prop glycol ester, alkyl aryl sulfate, quaternary ammonium erty that its final non-liquid state, during or as a result of compound and the like. One suitable method of prepara a glove puncture within a glove in accordance with the tion of an ointment base is to separately heat (for exam present invention, is incapable of flow like a liquid. (See ple with use of a steam bath) the aqueous phase(s) with Remingtons Pharmaceutical Sciences: 1965-pages 55 its additives and the non-aqueous phase(s) until each 456-457 and 525-556). phase is in a suitably softened, melted or liquid state, and Oleaginous base ointments may include the follow until each phase has attained approximately the same ing: (1) fats and fixed oil bases such as benzoinated lard temperature. The heating may be used to attain a tem optionally stiffened with beeswax or synthetic cetyl perature of between about 25 and 200 C., preferably esters wax (also known as carats bases); (2) optionally between about 45 and about 95 degrees centigrade. hydrocarbon bases such as petroleum Jelly or petrola Preferably the aqueous and non-aqueous phases may be tum NF of any color (i.e., bleached white or yellowed) then mixed at about the same temperature, until a stiffened with wax or other known stiffening agents, smooth creamy mixture is obtained. Stirring may be mineral oil stiffened with heavy hydrocarbon waxes continued while the mixture cools as desired before it is (i.e., waxes of about 1300 molecular weight is sold by 65 added to a glove. E.R.Squibb & Co. as Plastibase or Jelene); or (3) option Optionally, some non-liquid antiseptic compositions ally silicones such as for example Dow Corning 200 may not contain a liquid component. These non-liquid stiffened with wax or other stiffening agents. antiseptic compositions may comprise a mixture of non 5,357,636 27 28 liquid antiseptics and additives. For example, the com photericin B, tobramycin, a penicillin, a cephalosporin, position may appear for example as a dry powder or as salicylic acid, trichloroacetic acid, benzoic acid, pyro a paste. Pastes tend to be stiffer, less greasy and more gallol. NFX, pyrogallic acid, sodium benzoate, boric liquid absorptive than ointments. Pastes may contain acid, sodium borate, lactic acid, sodium lactate, chlora Starch, a pectin, zinc oxide, calcium carbonate, and/or mine, chloramine T, silver nitrate, ammoniacal silver talc in the base and are useful as a means for absorbing nitrate solution, eugenol, elemental iodine, sodium io Secretions and their contaminants from acute wounds. dide, potassium iodide, calcium iodide, ammonium io For the present invention, the non-liquid antiseptic dide, silver iodide, colloidal silver iodide in gelatin, composition should ideally have the following six prop silver lactate, ferrous iodide, mercuric iodide red, mer erties: (1) does not retard wound healing; (2) has a low 10 curic oxide red, strontium iodide, lithium iodide, mag Sensitization index; (3) has a low index of irritation; (4) nesium iodide, zinc iodide, silver iodide, selenium io has good storage stability; (5) has a minimum number of dide, thymol iodide NFX, dithymol diiodide, iodinated ingredients; and (6) is easy to compound or make. How derivatives of thymol, other iodide salts, povidone-io ever, to some extent most antiseptic compositions do dine, iodoform, iodinated organic compounds, iodol, interfere with cell wound healing, do sensitize the skin 15 iodopyrrol, other iodophors, chlorinated lime, bromide and do irritate the skin. It follows then that the design of salts, sodium bromide, merbromin NF, other bromo a glove that can provide a non-liquid antiseptic compo phors, other brominated chemicals, sodium fluoride and sition and that can comply with the above six criteria other fluorinated chemicals and fluorophors, Lysol, may either not be possible or may not be suitable if the Nonidet P40, phenyl mercuric acetate, potassium mer glove then can not function adequately to help to rap 20 curic iodide, proflavine hemisulfate, 3,6-diaminoacri idly kill infectious pathogens such as HIV or hepatitis B dine bisulfate, formaldehyde, glutaraldehyde, parsfor virus on contact. Thus, some side effects of the present maldehyde, butyl hydroxybenzoate, mercurous chlo invention may need to be tolerated by the glove wearer ride, iodochlorhydroxyquin, zinc nitrate, zinc sulfate, in order to lower their risk of squiring a dangerous cadmium sulfate, thimerosal NF, zinc oxide, zinc ace possibly lethal infection such as HIV or hepatitis B virus 25 tate, zinc chloride, silver nitrate, silver sulfadiazine, from a glove puncture by an object contaminated with hydrogen peroxide, urea hydrogen peroxide, hydrogen HIV or hepatitis B virus. peroxide carbamide, benzoyl peroxide, calcium perox For the present invention, the termantiseptic is meant ide, magnesium peroxide, barium peroxide, strontium to include but not be limited to the following: antimi peroxide, sodium peroxide, potassium perchlorite, so crobial agents, antibiotics, chemotherapeutic agents, 30 dium perchlorite, calcium perchlorite, magnesium per any antiseptics, antiviral agents, viricidal agents, bacter chlorite, zinc perchlorite, zinc peroxide, zinc carbonate, iocidal agents, antifungal agents, antiparasitic agents, zinc hydroxide, zinc sulfate, succinyl peroxide, succin and the like. The words antiseptic, disinfectant, and chlorimide NF IX, N-Chloro-succinimide, potassium germicide all connote an agent which can kill microbes permaganate, sodium chlorate, potassium chlorate, phe or infectious pathogens upon contact and thousands of 35 nol, sodium phenolate, domiphen bromide, salicylic chemical compounds are known which have antiseptic acid, bismuth-formic-iodide, bismuth subgallate, baci properties (For some examples see Remingtons Phar tracin zinc, sodium lauryl sulfate, carbamide peroxide, maceutical Sciences: 1985, 1990 and Harvey, 1985). sodium borate, oleic acid-iodine, piperonyl butoxide, The antiseptic used in some embodiments of the pres sodium peroxyborate monohydrate, ammonium ichtho ent invention may be selected from the group consisting sulfonate, eucalyptol, menthol, Witch Hazel, camphor, of chlorhexidine gluconate, chlorhexidine acetate, tannic acid, camphorated phenol, phenol glycerin, chlo chlorhexidine hydrochloride, chlorhexidine, other roxylenol, 4-chloro-3,5-xylenol, chloroquinaldol, nali chlorhexidine salts, other hexamethylenebis biguanides, dixic acid, zinc phenol-sulfonate, zinc sulfocarbolate, Octoxynol, nonoxynol-9, methanol, ethanol, isopropa hydroxynalidixic acid, pipemidic acid, norfloxacin, nor nol, allyl alcohol, rubbing alcohol NF, sodium hypo 45 floxacin hydrochloride, other quinolones, 8-hydrox chlorite, potassium hypochlorite, calcium hypochlorite, youinoline sulfate, sodium phenolate, thyme oil, o magnesium hypochlorite, sodium dichloroisocyanurate, cresol, m-cresol, metacresylacetate, p-cresol, cresol NF, sodium perborate NF, sodium hydroxide, potassium 4-chloro-m-cresol, 4-chloro-S,5-xylenol, saponified cre hydroxide, magnesium hydroxide, calcium hydroxide, sol solution NF, methylphenol, ethyl phenol, other ammonia, ammonium hydroxide, lithium hydroxide, 50 alkyl phenols, o-phenyl phenol, other aryl phenols, barium hydroxide, silver hydroxide, other metal hy bis-phenols, phenyl-mecuric chloride, phenylmecuric droxides, sodium tetradecyl sulfate, sulfur dioxide, pen borate, resorcinol, resorcinol monoactetate NF, ortho tationic acid, colloidal sulfur, sulfurated potash, sub phenylphenol, chloroxylenol, hexyl-resorcinol, para limed tyrothricin, hexachlorophene, hypochlorous acid, chlorophenol, paratertiary-amylphenol, thymol, chlo other chlorophors, acetic acid, hydrochloric acid, sulfu 55 rothymol NF, menthol, butylparaban, ethylparaben, ric acid, sodium acetate, aluminum acetate, acetarsone, methylparaben, propylparaben, triclosan, bithionol NF, aluminum subacetate, cadmium sulfide, selenium sul o-benzyl-p-chlorophenol, hexachlorophene, poloxamer fide, other metal sulfides, bacitracin, calomel, chiniofon, 188, benzalkonium chloride where the alkyl groups creosote, diiodohydroxyquin, eucalyptol, eucalyptus attached to the nitrogen represent any alkyl from CH3 oil, glycobiarsol, gramicidin, hexyl resorcinol, methy to C18H37, methylbenzethonium chloride, cetrimonium lene blue, peppermint oil, phenylethyl alcohol, phenyl bromide, abikoviromycin, acetylenedicarboxamide, ac salicylate, methyl salicylate, pine tar, pine oil NF, pine etyl sulfamethoxypyrazine, triclobisonium chloride, oil emulsion, tertiary terpene alcohols, secondary ter undecoylium chlorideiodine, coal tar solution, furazoli pene alcohols, alpha-terpineol, borneol, fenchyl alchol, done, nifuroxime, nitrofurazone NF, nitromersol NF, o-methylchavicol, polymixin B sulfate, colistin, chlo 65 oxychlorosene, sodium oxychlorosene, parachlorophe ramphenicol, tetracycline, erythromycin, gentamycin, nol NF, camphorated parachlorophenol NF, phenyl mafenide acetate, neomycin sulfate, sulfisoxazole diola mercuric nitrate NF, gentian violet USP, hexamethyl mine, sulfacetamide sodium, gentamycin sulfate, am para-rosaniline chloride, rosaniline chloride, pentame 5,357,636 29 30 thylpararosaniline chloride, methylrosaniline chloride, tives which may be added to the non-liquid antiseptic tetramethylpararosaniline chloride, nonylphenox composition include a pH buffer to stabilize the pH, ypolyethoxyethanol, methoxypolyoxyetheneglycol 550 such as for example a pH buffer of ascorbic acid and laurate, oxyquinoline benzoate, p-triisopropylphenox ascorbate salts, a phosphate buffer, an amino acid ypolyethoxy-ethanol, halazone NF, dichloramine-T, buffer, a GOOD Buffer, sulfate buffers, a zwitterionic benzethonium chloride, econazole, cetylpyridinium pH buffer, other pH buffer systems; free radical scaven chloride, methylbenzethonium chloride, cetyldimethyl gers, metal ion chelators and reducing agents such as benzylammonium chloride, dichlorobenzalkonium dithiothreitol (DTT) may also be useful. Antiseptics chloride, domiphen bromide, triclocarban, clo whose activity is stabilized by a metal ion chelator or trimazole, ciclopirox olamine, undecylenic acid, 10 pH buffer include at least the following antiseptics: miconazole, tolnaftate, acriflavine, euflavine, 3,6- hydrogen peroxide, benzoyl peroxide, other peroxide diamino-10-methylacridium chloride, 3,6-diamino-acri antiseptics, sodium hypochlorite, potassium hypochlo dine, acid acriflavine, 5-aminoacridine hydrochloride rite, sodium dichloroisocyanurate, hypochlorous acid, monohydrate, malachite green G, dodecyltrimethylam iodine, sodium iodide, potassium iodide and other halo monium bromide, tetradecyltrimethylammonium bro 15 gen-releasing antiseptics. The term halogen is meant to mide, dequalinium chloride BP, dibromopropamidine include any of the halogens: fluorine, chlorine, iodine, isethionite, hexadecyltrimethylammmonium bromide, and bromine in any of their their elemental states, iso chloroazodin NF X, N-chloro-p-toluenesul morphic forms, or reduced forms. fonamidosodium, 4-(dichloroamino)sulfonyl)-benzoic For the present invention the term non-liquid antisep acid, methenamine, methenamine mandelate, methena 20 tic composition is meant to include the following non mine hippurate, octoxynol 9, phenazopyridine hydro liquid physical states for the antiseptic composition: chloride, 9-aminoacridine hydrochloride, bismuth tri powdered solids of any powder grain size, foam, non bromophenate, p-tert-butylphenol, cetyldimethyle liquid cream, gel, jelly, paste, cerate, ointment, emul thylammonium bromide, chlorothymol, cloflucaban, sion base, plaster, putty, glycerogelatin, and any other clorophene, cloroxine, 8-hydroxyquinoline, merbromin, 25 non-liquid states forms that may be suitably used in the mercuric oxide yellow, ammoniated mercury, p-tert present invention (See Remington's Pharmaceutical pentylphenol, phenylmercuric acetate, phenylmercuric Sciences, 1965: Chapter 37-pages 525-556, and pages nitrate, propylene oxide, zinc pyrithione, zinc bacitra 455-459. In any of these physical states the non-liquid cin, chlortetracycline hydrochloride, calcium chlortet antiseptic composition may comprise a mixture(s) of racycline, oxytetracycline hydrochloride, beta-propi 30 liquids and solids and for some embodiments of the olactone, acyclovir, acyclovir sodium, amantadine hy present invention, may also include a gaseous compo drochloride, cytarabine, idoxuridine, interferon, gamma nent. interferon, ribaviron, rifampin, suramin, trifluridine, Gas producing substances in suitable liquids or in vidarabine, zidovudine, methisazone, tumor necrosis non-liquid compositions may be used to produce a quan factor, ampligen, ansamycin, (E)-5-(2-bromovinyl-2'- 35 tity of gas, the gas comprising in some embodiments of deoxyuridine, butylated hydroxytoluene, castamosper the present invention: (a) a gas useful for producing an mine, dextran sulfate, dideoxycytidine, dideoxyadeno expanding foam-state antiseptic composition; (b) a gas sine, dideoxyinosine, Peptide-T, dihydromethyl useful for increasing the gas pressure in the glove wall pyridinylcarbonyloxyazidodideoxythymidine, ganci as a means for forcibly expelling the non-liquid antisep clovir, 2'-fluoro-2'-deoxy-5-iodo-ara C, phosphonofor tic composition from the glove wall puncture; or (c) an mate, rimantadine hydrochloride and the like and their antiseptic with the rapid diffusion rates inherent to derivatives and mixtures thereof. For optimal antiseptic gases. Gas-producing substances include the following activity, nonoxynol-9 is bufferred to a pH between chemical combinations: (1) the combination of a bicar about 5.0 and about 4.0; preferably the pH may be about bonate or carbonate compound with an acid to form 4.5 in a non-liquid antiseptic composition containing 45 carbon dioxide gas; (2) the combination of a peroxide or nonoxynol-9. a perchlorite compound with a chemical catalyst such The non-liquid antiseptic composition may be de as for example, manganese dioxide to form oxygen gas; signed to be capable of specifically killing, inactivating and (3) the combination of a halogen or halogenated and/or otherwise destroying a particular infectious compounds with an acid or oxidizing agent to form a pathogen. Alternatively, the non-liquid antiseptic com 50 halogen gas. position may be designed to have a broad spectrum The bicarbonate compound may be selected from the antiseptic activity against infectious pathogens. Prefera group consisting of the following: sodium bicarbonate, bly, a glove in accordance with the present invention potassium bicarbonate, calcium bicarbonate, magne contains an antiseptic formulation capable of at least sium bicarbonate, zinc bicarbonate, ammonium carbon inactivating or killing HIV or Hepatitis B virus. Prefer 55 ate, tetramethylammonium bicarbonate, choline bicar ably the antiseptic used in the glove is selected from the bonate, tetraethylammonium bicarbonate, propylene group consisting of povidone-iodine, elemental iodine, carbonate, butylene carbonate, other alkyl ammonium sodium iodide, potassium iodide, sodium hypochlorite, bicarbonates, benzalkonium bicarbonate, alkyl nonoxynol-9, and chlorhexidine gluconate and mix pyridinium bicarbonate, tetraphenylammonium bicar tures; antiseptics of known effective viricidal and antivi bonate and mixtures thereof. The carbonate compounds ral activity. corresponding to the above mentioned bicarbonates The inclusion of a metal ion chelator such as EDTA, may be substituted provided that additional acid is pro EGTA, NTA, HEDTA or other ion chelator at a con vided for the reaction with the carbonate. Bicarbonate centration of between about 5 micromolar to about 5000 and carbonate compounds release carbon dioxide gas micromolar, in the non-liquid antiseptic composition 65 when reacted with mineral or organic acids. may be useful to help preserve the activity of the anti The peroxide compounds may be selected from the septic by chelating ions (cations or anions) which may group consisting of the following: hydrogen peroxide, chemically inactivate the antiseptic. Other preserva urea hydrogen peroxide, benzoyl peroxide, succinyl 5,357,636 31 32 peroxide, barium peroxide, calcium peroxide, magne about 6600 molecular weight, other liquid emulsifiers, sium peroxide, Sodium peroxide, strontium peroxide, olive oil, cottonseed oil, corn oil, soybean oil, wheat zinc peroxide, other peroxide compounds and mixtures germ oil, linseed oil, pine oil, almond oil, macadamia oil, thereof. When exposed to fine metal powders or metal coconut oil, jojoba oil, peanut oil, persia oil, castor oil, oxide catalysts such as manganese dioxide, the perox other vegetable oils, other plant oils, cod liver oil, shark ides in aqueous solutions buffered at neutral pH or alka liver oil, mink oil, other animal oils, squalene, other line pH generally can release oxygen gas or can form liquid steroids, other suitable relatively non-toxic natu hydrogen peroxide which subsequently releases oxygen rally occurring liquids, other suitable man-made liquids, gas. Urea hydrogen peroxide can decompose into oxy and the like and mixtures thereof. gen gas and urea when exposed to an alcohol or an O Suitable materials, suitable liquids and other suitable ether. chemicals which may be used in the present invention Halogens and halogenated compounds are capable of are considered “suitable' for the present invention reacting in aqueous or aqueous/alcoholic solutions with when these substances (1) can provide to some degree an acid to release potent antiseptics in soluble and gase of suitable function for the present invention at some ous forms. The useful halogens include fluorine, chlo 15 concentration and (2) at the concentration used, cause rine, bromine and iodine. In general, a halogenated or tolerable side-effects and tolerable toxicity to the human halogen antiseptic can raise the halogen concentration body as measured against the protective benefits of the in the mileau of a sample of infections pathogen to sev present invention. For example, some of the more pow eral parts per million (ppm) of halogen. The potent and erful non-liquid antiseptic compositions in the present potentially rapid antiseptic activity of a halogen against 20 invention may help to protect a gloved individual from a virus, a bacteria or other infectious pathogens is gen acquiring a systemic HIV infection after a becoming erally held to be due to the high chemical reactivity of injured on a hand by an HIV and blood-tainted needle. the halogen against the proteins of the infectious patho The process of using the present invention to protect gen essential for its viability and reproduction. the individual may temporarily impair the healing pro A chlorine containing antiseptic compound such as 25 cess in the needlestick wound because of the effects of Sodium hypochlorite can react with a liquid acid such as the antiseptic composition. However, while the present an aqueous solution of hydrochloric acid to produce a invention may impair wound healing, this negative ef mixture of hypochlorous acid, chlorine dioxide, and fect is minor and quite tolerable in view of the capability chlorine gas which as a combination form a rapid of the present invention to help to prevent a serious acting, potent antiseptic mixture. A solution of 0.1-5 30 infection from occurring to a gloved individual after a percent elemetal iodine, 0.1 to 10 percent iodide salt in glove wall puncture. an aqueous solutions containing 25 to 95 percent of a It may be useful to include at least one surface active suitable alcohol becomes a more potent antiseptic when agent in the non-liquid antiseptic composition to facili acidified to below pH 7, even more potent below pH tate the coating of the glove-puncturing object with the 6.5. From the reaction of water with I2 (elemental io 35 non-liquid antiseptic composition. The surface active dine) and iodide ion at pH 6.5 or lower pH, the reactive agent may be selected from the group consisting of iodide compounds, HOI (hypoiodous acid) and HI dodecyldimethylamine oxide, lauryldimethylamine ox (iodic acid) are formed in sufficient concentration as to ide, other similar oxides, stearic acid, dibutyl adipate, provide rapid and potent antiseptic activity. In addition, octyl stearate, octyl alcohol, sodium cetearyl stearate, iodide anion (I) can react with 2 to form 3, a solu isopropyl myristrate, palmitic acid, other fatty acids, ble complex form of iodine that is useful as a reservoir stearyl alcohol, colloidal magnesium aluminum silicate, of I2 in solution. colloidal silicon dioxide, other mineral colloids, ca The non-liquid antiseptic composition may contain a prylic triglyceride, capric triglyceride, decyl-beta-D- liquid selected from the group consisting of water, glucopyranoside, cetostearyl alcohol, nonyl-beta-D- methanol, ethanol, isopropanol, propanol, allyl alcohol, 45 glucopyranoside, octyl-beta-D-glucopyranoside, mag butanol, isobutanol, sec-butanol, tert-butanol, benzyl nesium stearate, calcium stearate, potassium stearate, alcohol, nonxynol-9, n-octyl alcohol, 2-octyl dodeca aluminum stearate, zinc stearate, triethanolamine stea nol, other liquid alcohols, glycerol, propylene glycol, rate, other stearates, sodium lauryl sulfate, heptyl-beta other liquid glycols, 1,2,6-hexanetriol, other liquid tri D-glucopyranoside, hexyl-beta-D-glucopyranoside, ols, polyethylene glycol of between about 150 to about 50 dodecyl-beta-D-maltoside, decyl-beta-D-maltoside, so 700 molecular weight, other liquid polyethylene gly dium dodecylsulfate, sodium oleate, potassium laurate, cols, other liquid glycols, other liquid triols, urea, other sodium laurate, sodium laurylsulfate, glycerol monoste liquid amides, acetone, methyl ethyl ketone, ethyl ke arate, propylene glycol monostearate, other fatty acid tone, methyl isopropyl ketone, 2-pentanone, ethyl ace esters, bis(2-ethylhexyl)sodium sulfosuccinate, propy tate, ethyl propionate, ethyl butyrate, ethyl valerate, 55 lene glycol monolaurate, N-dodecyl-sulfatobetaine, methyl acetate, propyl acetate, isopropyl acetate, butyl octyl-beta-D-thiogluco-pyranoside, heptyl-beta-D-thio acetate, sec-butyl acetate, tert-butyl acetate, amyl ace glucopyranoside, N-dodecyl-N,N-dimethyl-glycine, tate, penty acetate, isopentyl acetate, benzyl acetate, cetyl alcohol, N-decylsulfatobetaine, digitonin, 1,2,6- 2-methoxyethanol, 2-methoxyethyl acetate, 2-ethoxye heaxanetriol, N-hexyadecylsulfatobetaine, N-tet thanol, 2-ethoxyethyl acetate, other liquid ketones ex radecylsulfatobetaine, dioctyl sodium sulfosuccinate, cept methyl n-butyl ketone, other liquid esters, other N,N,bis(3-D-gluconamidopropyl)-cholamide, sodium liquid aldehydes, formic acid, other liquid organic acids deoxycholate, N,N,bis(3-D-gluconamidopropyl)-deox including liquid carboxylic acids, mineral oil, silicone ycholamide, glycerol monostearate, N-octylsul oil, other chemically derived oils, hexamethyl disilox fobetaine, sodium taurodeoxycholate, sodium cholate, ane, other liquid silanes, glycerol trioctanoate, decyl 65 sodium taurocholate, sodium glycocholate, other ste oleate, cetearyl isononanoate, other liquid soaps, other roids, cetyltrimethylammonium bromide, 3-(3- liquid detergents, dimethicone, other liquid silicones, cholamidopropyl)dimethyl ammonio)-1-propanesulfon perfluropolymethylisopropyl ether of about 1500 to ate, 3-(3-cholamidopropyl)dimethylammonio)-2- 5,357,636 33 34 hydroxypropane-1-sulfonate, octanoyl-N-methylgluca mentioned dyes, any other dyes, any iron oxide, tita mide, nonanoyl-N-methylglucanide, decanoyl-N- nium dioxide, any other opacifier, and mixtures thereof. methylglucamide, nonyl-N-methylglucamide, lecithin, The colorant in the non-liquid antiseptiuc composition, lysolecithin, nonaethylene glycol monododecyl ether, glove walls, or on the glove wall surfaces may not only nonaethylene glycol octylphenol ether, nonaethylene absorb certain wavelengths of visible light and thus glycol octylcyclohexyl ether, heptaethylene glycol appear colored, but may be fluorescent, phosphores octylphenyl ether, heptaethylene glycol octylcy cent, or glow in the dark after exposed to light as a clohexyl ether, polyoxyethylene (10) monolauryl ether, means of enhancing the coloration. polyoxyethylene (8) isotridecyl ether, polyoxyethylene Using one or more of the forementioned colorants, (10) isotridecyl ether, polyoxyethylene (15) isotridecyl 10 coloration may also function as a form of glove wall ether, polyoxyethylene (9) lauryl ether, polyoxyethyl decoration to give a glove in accordance with the pres ene (23) lauryl ether, octaethylene glycol monododecyl ent invention a more pleasant or interesting appearance. ether, nonaethylene glycol monododecyl ether, other For some embodiments of the present invention, a col ethers, polyethylene polypropylene glycol, sorbitan ored design or print pattern is envisioned which com monopalmitate, sorbitan monooleate, sorbitan monoste 15 prises a pattern of small animals including such as teddy arate, polyoxyethylene sorbitan monolaurate, polyoxy bears, lions, giraffes, monkeys, dogs, cats, mice, cows, ethylene sorbitan monooleate, other sorbitans, polyox chickens, pigs, sheep, elephants, birds or other animal yethylene-4-lauryl ether, polyethylene glycol 400 mon facsimiles. Other figures decorating the glove may in ostearate, polyoxyethylene-4-sorbitan monolaurate, Po clude clowns, toys, fire trucks, cowboys, dinosaurs, lyoxyethylene-20-sorbitan monooleate, polyoxyethy outdoor scenes and the like; in general any scene or lene-20-sorbitan monopalmitate, polyoxyethylene-20 object which is pleasing to children and other individu sorbitan monolaurate, polyoxyethylene-40-stearate, di als is imagined to be a useful decoration for the present methicone, simethicone, dimethylpolysiloxane, other invention. Glove coloration may be more abstract in siloxanes, sorbitan trioleate, sorbitan tristreate, propy pattern as well, may include a camouflage pattern, or lene glycol monostearate, sorbitan sesquioleate, diphe 25 more simply color the glove a single color such as pink, nyl-methylsilicone, lauryldimethylbenzylammonium purple, white, green, a pastel color, or any other color chloride, a perfluropolymethylisopropyl ether of about including a fluorescent color. Preferably glove wall 1500 to about 6600 molecular weight, acacia, type A coloration renders the glove wall opaque to help to gelatin, type B gelatin, egg yolk phospholipids, soybean mask the appearance of the liquid antiseptic composi phospholipids, other lipids, cholesterol, colloidal alumi 30 tion within the glove wall. In addition, printed diagrams, nun silicate, colloidal magnesium hydroxide, stearic instructions expressions and any other information may acid, methylparaben, propylparaben, other suitable sur be printed onto the glove wall. Printing may accorn face active chemical agents and the like and their deriv pany the coloration and glove wall decorations or may atives and mixtures thereof. appear alone on the glove wall. One object of glove The non-liquid antiseptic composition may contain an 35 wall coloration, decorations, and printing is to entertain algesic agent that is capable of increasing the pain sensa and to distract the fears or other negative thoughts of tion that can be felt by a hand when the hand has been the glove wearer or patients seen by the glove wearer. wounded by a glove-puncturing object, as a means for Such gloves should be particularly amusing to dental rapidly alerting the glove-wearing individual. The alge patients and other health care patients. For the present sic agent may be selected from the group consisting of 40 invention the method of achieving the coloration deco formic acid, acetic acid, citric acid, sodium hydrogen ration and printing of the glove wall is not conceived to citrate, other acidic citrate salts, other organic acids, be limited to any particular artistic or commercial art phosphoric acid, sodium hydrogen phosphate, sodium methodology. phosphate, potassium hydrogen phosphate, other acidic The non-liquid antiseptic composition may further phosphate salts, other phosphate salts, hydrochloric 45 contain a concentration of a vasocontricting agent, the acid, sulfuric acid, sodium hydrogen sulfate, sodium concentration ranging from about 1 part vasocontrict sulfate, other acidic salts, other mineral acids, sodium ing agent per 200,000 parts of non-liquid antiseptic com hypochlorite, potassium hypochlorite, other hypochlo position to about 1 part vasoconstricting agent per 2,000 rite salts, bradykinin, substance P, bee venom, wasp parts of non-liquid antiseptic composition. Should a venom, ant venom, other suitable algesic peptides, alge 50 person using the present invention on a hand become sic proteins, algesic ionophores, potassium chloride, wounded on that hand, then the presence of a vasocon potassium citrate, potassium sulfate, potassium phos stricting agent in the non-liquid antiseptic composition phate, potassium carbonate, potassium bromide, potas may be useful to help cause a reduction in blood flow in sium iodide, potassium fluoride, potassium hydroxide, the hand wound and thereby may help to reduce the potassium nitrate, other potassium salts, other potassium 55 immediate dispersion of the infectious pathogen from containing chemicals, other algesic organic chemicals, the wound site by blood flow into the systemic circula other algesic salts, and the like and mixtures thereof. tion (i.e., the blood circulation, lymphatic circulation, The above algesic agents may also be capable of provid interstitial serum circulation, or by other systemic fluid ing an acidifying function for some embodiments of the circulations) of an individual. Any suitable vasocon present invention which can enhance the antiseptic stricting agent may be selected. Some of the well acitivity by providing a source of protons, by lowering known vasocontricting ethylamine compounds may be the pH of the composition or by other means. used or any other suitable group of vasoconstricting The non-liquid antiseptic composition may also con compounds may be used. Preferably the vasoconstrict tain a colorant or colored substance as a means for ing agent is selected from the group consisting of epi providing a color signal to an individual when the glove 65 nephrine, norepinephrine, phenylephrine, ephedrine, wall has been punctured by the glove-puncturing object metaraminol, methoxamine and mixtures thereof. or is otherwise damaged to some extent; the colorant The non-liquid antiseptic composition can contain a can be selected from the group consisting of the fore viscosity-modifying agent such as a polymer or a high 5,357,636 35 36 ly-branched molecule of high molecular weight, useful ignated Methocel 60, HG, Methocel HG65, Methocel as a means for increasing the viscosity of the non-liquid HG70, Methocel HG90 (wherein the number refers to antiseptic composition so that the composition is pre the approximate gel point of a 2 percent solution), other vented from flowing as a liquid until contact may be alkylated celluloses including ethylcellulose, hydroxy made with a hand or a hand wound as a result of a glove ethyl cellulose, propylcellulose, microcrystalline cellu puncture. The viscosity-modifying agent may bind, lose (Avicel PH, trademark of FMC Corporation, associate, solvate with or otherwise complex with liquid Philedelphia, Pa.), other suitable chemically-modified Solvent molecules in the antiseptic composition and can celluloses, glycerol, propylene glycol, pyroxylin, poly thereby lower the effective solvent concentration in the ethylene glycols of between about 150 to more than antiseptic composition. The final viscosity of the non 10 about 6000 molecular weight, polyethylene glycol 400, liquid antiseptic composition may exceed 5000 centi polyethylene glycol 4000, polyethylene glycol 4000, poise at normal glove temperatures which are generally polyethylene glycol 6000, gelatin A, gelatin B, glycine expected to range between about 10° C. to about 42 C. rated gelatin, wool fat, beeswax, White petrolatum However, some of the non-liquid antiseptic composi USP, Petrolatum NF (Petroleum Jelly with a melting tions used in the present invention may have a viscosity 15 point of 42°-60° C), Plastibase (tradename "Plastibase” below 5000 centipoise; an example would be a foam from E.R. Squibb & Co., also called Jelene: a combina forming or foam-type, non-liquid antiseptic composi tion of mineral oils and heavy hydrocarbon waxes with tion. a molecular weight of about 1300), anhydrous lanolin The non-liquid antiseptic compositions used in the USP, microcrystalline wax, cholesterol, white wax, present invention can be subdivided into two catego 20 hard paraffin wax, yellow soft paraffin wax, white soft ries: Group A non-liquid antiseptic compositions do not paraffin wax, sodium lauryl sulfate, stearyl alcohol, ordinarily generate a gas during glove wall damage carbowax polyethylene glycol 1000, carbowax polyeth whereas Group B non-liquid antiseptic compositions ylene glycol 1500, carbowax polyethylene glycol 1540, are capable of generating some gas during glove wall carbowax polyethylene glycol 4000, carbowax polyeth damage. Both Group A and Group B non-liquid anti 25 ylene glycol 6000, other proteins, dimethicones includ septic compositions are defined for the present inven ing those more than 1000 centistokes in viscosity, sime tion as being not capable of flowing like a liquid. thicone, dtmethylpolysiloxane, perfluropolymethyliso The non-liquid property of Group A antiseptic com propyl ethers of 1000 to more than 6600 molecular positions for the present invention can be easily demon weight, starch, other alkylated starches, other chemi strated by the following test. A sample of a Group A 30 cally-modified starches, bentonite USP, sodium benton non-liquid antiseptic composition warmed to a tempera ite, potassium bentonite, calcium bentonite, magnesium ture of 30° C. is placed in an open glass cylindrical tube bentonite, hydrogen bentonite, Voloclay bentonite (a 1.0 cm high and 1.0 cm in diameter standing on a glass combination of sodium bentonite, potassium bentonite, plate in a sealed test chamber controlling the tempera calcium bentonite, magnesium bentonite, and hydrogen ture to 30° C., the pressure to 1 atmosphere and the 35 bentonite), attapulgite (a hydrous magnesium aluminum humidity to 50 percent relative humidity. The cylinder silicate that is heat-activated), Veegum (a colloidal mag is lifted by a mechanical means and the sample is ob nesium aluminum silicate), carbopol 934 at neutral pH served for at least five minutes. A liquid sample placed (a trademark acidic polymer of B.F. Goodrich Chemi in the cylinder will begin to immediately leak out from cal Co.), benzoinated lard, guar gum, agar, pulverized the open cylinder bottom where it rests on the glass natural sponge, potato starch, corn starch, other vegeta plate. In contrast for the present invention, a non-liquid ble starches, other plant cellulose fibers, other plant or antiseptic composition will not begin to leak out from mineral fibers or polymers, other synthetic polymers the bottom of the cylinder. Five minutes after the cylin and mixtures thereof. It is useful to include the foremen der is lifted, a liquid will increase its 1 cm sample diame tioned viscosity-modifying polymers when making ter to more than three cn and will substantially flatten 45 compound non-liquid antiseptic compositions such as in height, whereas a non-liquid sample will not. Because for example gels, foams, pastes, puttys, greases, and the gas production by a test sample of a Group B non-liquid like and mixtures thereof. The viscosity-modifying pol antiseptic composition may cause the test sample diame ymer help to prevent the antiseptic composition from ter to expand in the testing chamber, the Group B anti flowing like a liquid from the glove punture in an un septic compositions should be tested only after gas pro 50 controlled manner. Certain polymers such as starch or duction and associated volume expansion of the test povidone or other molecules may complex iodine or sample have gone to completion. Powdered antiseptic other antiseptics and buffer their free concentration in compositions which are solids are clearly not liquids the non-liquid antiseptic composition. This effect may and do not need the above test to demonstrate that they need to be taken into account when formulating the are non-liquids. 55 non-liquid antiseptic composition. The viscosity-modifying polymer or agent may be The non-liquid antiseptic composition may also con Selected from the group consisting of xantham gum, tain a chemical odor or odorant that is capable of caus gum acacia, gum tragacanth, agar, glycyrrhiza, polyvi ing either a pleasant or an unpleasant (malodorous) nylpyrrolidone polymers having an average molecular smell. The chemical smell may be caused an aromatic weight between about 500 to about 5000 grams/mole, oil, a perfume, an ester, a ketone, an aldehyde, an or cross-linked polyvinylpyrrollidone polymers, sodium ganic acid, a sulfide, an amine, a flower extract, a plant alginate NF, pectin NF from citrus fruit or apple pom extract, an animal extract, a mineral extract, or any ace, other plant gums, theobroma oil (also known as other suitable chemical. For example the composition cacao butter or cocoa butter), cellulose, methyl cellu may contain a pleasant scented volatile oil such as pep lose (Methocel, trademark of Dow Chemical Co.) car 65 permint oil, menthol, oil of wintergreen, lemon oil and boxymethylcellulose (CMC) sodium, hydroxyethyl cel the like, or an unpleasant odor such as pyridine, putres lulose (Cellosize, trademark of The Carbide and Carbon cene, ammonia, vinegar, formaldehyde and the like. Chemicals Corp.), hydroxpropylmethylcelluloses des When the glove is damaged, the vapors of the chemical 5,357,636 37 38 odor can freely diffuse from the compartment storing still melted, the extra non-liquid antiseptic composition the non-liquid antiseptic composition into the air; useful can be removed from or added to the open end of com as a means for further alerting the glove wearer or partment 4. The back open end of a glove in accordance others that a protective glove has been damaged. with the present invention may be sealed to completely Another embodiment of the present invention can be 5 close compartment 4, or optionally compartment 4 may seen by comparing the two partially enlarged sectional be left open. Note in multiple layered gloves which are views of the glove encircled in FIG. 3: a finger wall not diagramed herein, compartment 4 may contain one Sectional view 11 and a wrist wall sectional view 12. of more of the substances which combined can form a The thickness of compartment 4 storing the non-liquid functional non-liquid antiseptic composition for the antiseptic composition in wrist wall 12 is significantly 10 increased by design compared to the thickness of the present invention. Thus compartment 4 as defined for compartment in finger wall 12. The entire wrist area of the present invention optionally may exist between only the glove is expanded by design so that the glove can some or all glove layers situated between the outermost store additional non-liquid antiseptic composition in the and innnermost layers comprising the glove wall. A wrist area. 15 reversible seal may be used at the open wrist end of the By massaging the glove, the stored non-liquid anti glove which comprises a zip-locking connection be septic composition can be redistributed by the glove tween the glove layers or any other suitable connecting wearer; useful as a means for forcing the non-liquid device can be used. Alternatively, a glove in accor antiseptic composition to redistribute to other regions dance with the present invention may have a simple of the glove needing additional non-liquid antiseptic 20 structural design as has been described in FIG. A composition such as the site of glove damage as de wherein inner glove layer 3 and outer glove layer 2 picted in FIG. 2D where an accumulation of the non have no special structural material connections. How liquid antiseptic composition can help to increase the ever, it is usually a disadvantage to leave compartment forced extrusion of non-liquid antiseptic composition 4 unclosed because the non-liquid antiseptic composi from the glove during glove massage. 25 tion in compartment 4 may dry out or may accidently A glove in accordance with the present invention become squeezed out (extruded) from the glove com may cover the fingers, palm, back of hand, wrist, fore partment during prolonged glove storage or glove arm or arm; any of these regions of the glove can be wear. In addition, if the non-liquid antiseptic composi modified by design so that a portion of compartment 4 tion is flammable, malodorous, contains a colorant, or is in the selected region may store additional non-liquid 30 otherwise deemed unpleasant then sealing compartment antiseptic composition. 4 may be necessary. By definition, the sealing of com Once a particular formulation of non-liquid antiseptic partment 4 brings the inner and outer glove layers or composition has been chosen, a two-layered glove or a multiple layers of the glove wall into physical contact multiple-layered glove with an intermediate compart so they become structurally connected at least at one ment containing a non-liquid antiseptic composition in 35 point. accordance with the present invention can be made A glue or any other connecting means or device may optionally by several methods. One of the simplest ways be used to seal or close compartment 4 at the open end to make a glove in accordance with the present inven of the glove layers. A glue can be used which is capable tion is first to form the inner glove layer on a hand of suitably bonding rubber, plastic or any other glove shaped mold by one of the known methods used to form layer materials forming the glove wall. The cured glue standard medical gloves. Any other suitable method for should not be solubilized nor weakened by contact with making a glove layer is also acceptable. Often the raw the non-liquid antiseptic composition. The preferred material used to make the glove layer is available in a sealing glue may contain a silicone, an epoxy polymer, liquified form which then permits the hand mold to be an epoxy resin, a cyanoacrylate, a cyanomethylacrylate, sprayed or dip coated with the liquid glove layer form 45 and the like, or any other effective glue or bonding ing-material to a suitable thickness. The outer glove agent that remains suitable in the presence of a particu layers can then be formed on a second hand mold in the lar non-liquid antiseptic composition. For example, one same manner. When making two-layered gloves or suitable commercially-available silicone rubber cement multiple-layered gloves in accordance with the present for bonding rubber to rubber or to plastic is Archer invention, the outer glove layer(s) may be made with a 50 Brand Silicone Rubber Cement (Radio Shack, Fort larger set of dimensions than the inner glove layer so Worth, Tex., 76102) which contains methyltriacetoxy that a suitably-sized compartment 4 for the non-liquid silane (CAS 004253343), ethyltriacetoxysilane (CAS antiseptic composition is formed when the glove is 017689779), polydimethylsiloxane, and silica (CAS assembled. After the glove wall layer materials have set, 0.07631869). congealed, reacted, dried, cured or solidified suffi 55 Another alternative method of making a glove in ciently, the outer surface of the inner glove layer or the accordance with the present invention is to first form glove layers of multiple layered gloves between may be each glove layer on a hand mold, and then slip (or slide) suitably coated with a selected amount of a non-liquid the outer glove layer(s) over the inner glove layer. antiseptic composition. Often the non-liquid antiseptic Non-liquid antiseptic composition is melted at a temper composition can be temporarily liquified by melting it at ature above 42 C. and then added to suitably fill con a tempertature above 42 C. (usually the melting tem partment 4 by using a tube, by an injection method, by perature is above 55° C); at such elevated temperatures, a spray means, or by any other method of addition of the antiseptic composition can then be readily poured, the non-liquid antiseptic composition into compartment sprayed, painted, coated or otherwise administered 4. The glove may then be allowed to cool to 23 C. conveniently onto the glove layer surfaces as desired. and/or the glove can then be sealed or left open at the The outer glove layer(s) can then be sequentially glove end and then cooled to 23 C. The order of the slipped over the inner glove layer coated with the non steps of assembly of the present invention is generally liquid antiseptic composition. While the composition is not important. 5,357,636 39 40 Another alternative method for making the present animal secretion, cotton fiber, another plant fiber, wool invention is to first add the selected non-liquid antisep fiber, another animal hair, leather, another animal fiber, tic composition in a melted state (at above 42 C.) begin animal skin, animal intestinal tissue, animal connective ning with the inside of the chosen outermost glove tissue, metallic fiber, mineral fiber, a glue comprising layer. Then sequentially, the more inner glove layers 5 one or more of the forementioned structural materials, can be inserted within the outer glove layer. These and mixtures thereof; and layers may optionally be coated with the non-liquid (b) optionally a colorant selected from the group antiseptic composition. Before or after the glove has consisting of titanium dioxide, a dye, an iron oxide and cooled to 23 C., the glove may optionally be sealed or mixtures thereof. left open at the glove end. O Case hardened rubber may be used in the present As mentioned, the non-liquid antiseptic composition invention when a surface of a rubber wall or structural may simply be a single powdered solid antiseptic sub element of the glove may need to have increased resist stance. The powdered antiseptic could be simply so ence to chemical solvents, to the antiseptic and to other dium iodide, another iodide salt or another antiseptic substances provided in the present invention. Case which is a solid, defined herein as substances which are 15 hardening rubber includes using processes that chemi Solid below 42 C. at normal atmospheric pressure and cally cross-link and strengthen the rubber polymer mol relative humidity. Generally a glove design in accor ecules on the surface of the rubber. In general, synthetic dance with the present invention, that could be made elastomer structural materials may be formed by poly rather simply and quickly by any individual, in anticipa merizing monomeric molecules by an emulsion or solu tion of needing such a protective medical glove for an 20 tion polymerization process. It is known that the rubber upcoming emergency situation, would be the use or polymers formed may additionally contain a curing wear of two standard medical gloves on each hand, agent such as sulfur or a peroxide to cross-link the rub having placed between the first and second glove on ber molecules. Sulfur may be used to crosslink diene each hand, a suitable amount of a non-liquid antiseptic containing elastomers while a peroxide is used to cross composition in between the gloves worn on each hand. 25 link a saturated polymer. It is also known to use an In general, no specific order and no specific process is accelerator such as for example an amine derivative, an envisioned for the steps of assembly of the present in aldehyde-amine condensation product, a thiazole, a vention in any of its embodiments which may comprise dithiocarbamate, a guanidine derivative, a thiuram, a the combination of the inner glove layer with optional xantate or a xantogenate to promote the reaction be intermediate glove layers and with the outer glove layer 30 tween the sulphur and the rubber molecules because between which glove layers may be added some sub this reaction is otherwise quite slow. It is also known to stances or all of the substances making up the non-liquid use a metal oxide activator to make the accelerator antiseptic composition, and optionally, the formation of more effective sometimes with an organic acid such as one or a multiple number of structural connections stearic acid. The rubber may further contain an antioxi between some or all of the glove layers of the glove 35 dant such as an amine or phenol derivative, a filler for wall of present invention. reinforcement or for coloration. The rubber may con Another embodiment of the present invention is illus tain a plasticizer or a softener such as an ester, an adi trated in FIG. 4 in the encircled partially enlarged sec pate, phthalate, silicate, stearate, phosphate, or mineral tional view; the glove wall may have one structural oil. The use of a plasticizer or softener in the non-liquid connection, two structural connections, or a plurality of 40 antiseptic composition may be used to help to maintain structural connection 13 (of a third material) in com the softness or plasticity of the rubber glove wall, but an partment 4 between the outer glove layer (first material) excess amount of the softener or the plasticizer may and the outer glove layer (second material). The third unsuitably modify the rubber wall properties par material forming a structural connection comprises: ticularily with latex rubber gloves. When the non-liquid (a) a structural material selected from the group con 45 antiseptic composition contains a softener such as min sisting of latex rubber, cis-1,4-polyisoprene rubber, cis eral oil and a glove wall is rubber, preferably the rubber polybutadiene rubber, neoprene rubber, nitrile rubber, wall is made of solvent resistant rubber such as for silicone rubber, polychloroprene rubber, another halo example neoprene or a cross-linked rubber. A resin(s) or genated rubber, a case-hardened rubber, another butadi a rosin(s) may be added to make the rubber tacky or ene rubber, a cross-linked rubber, isobutylene-isoprene 50 gummy. A typical rubber formulation may contain the 1. butyl rubber, butadieneacrylonitrile 1. nitrile rubber, following material composition: 100 parts of elastomers, styrene-butadiene rubber, ethylene-propylene copoly 1-4 parts of fillers, 0.5-2 part of stearic oils, 2-5 parts of mer, ethylene-propylene diene terpolymer, polyisobu zinc oxide, 1-12 parts of plasticizing oils, 1-3 parts of tylene, chlorosulphonated polyeten, ester-type urethan accelerators, 0.5-4 parts of antioxidants, 0-10 parts of rubber, polychlorimethyloxyran epichlorhydrin rubber, 55 resins, and 1-3 parts of sulphur. Infared or ultraviolet epichlorhydrin copolymer with ethyleneoxydichlorme light may be used to increase the case-hardening, cross thyloxyran copolymer, another rubber, cellulose ace linking and related chemical production of the rubber tate plastic, vinyl plastic, polyethylene plastic, polypro used in the present invention. pylene plastic, polyvinyl chloride plastic, polyvinyl It is another object of the present invention to pro acetate plastic, polystyrene plastic, polymethyl methyl vide a glove having a plurality of glove layers acting as acrylate plastic, polyacrylonitrile plastic, vinyllite plas a structural connection which reconfigures the com tic, saran plastic, polytetrafluoroethylene plastic, poly partment storing the non-liquid antiseptic composition trifluorochloroethylene plastic, nylon plastic, rayon into a plurality of compartments capable of storing the plastic, polycaprolactam plastic, polyester plastic, urea non-liquid antiseptic composition. formaldehyde plastic, polyurethane plastic, isotactic 65 It is another object of the present invention to pro polypropylene plastic, polyamide plastic, phenolic plas vide a glove having a plurality of glove layers acting as tic, silicone plastic, another plastic, another synthetic a structural connection which reconfigures the com organic fiber, silk fiber, another suitable fiber from an partment storing the non-liquid antiseptic composition 5,357,636 41 42 into a plurality of compartments (or subcompartments) glove wall cross-section) to comprise a sponge. The size storing some or all of the components capable of form of each compartment storing the liquid antiseptic com ing the non-liquid antiseptic composition. For some position is not generally critical. Also, any of the con embodiments of the present invention, it is conceivable partments, which for the present invention may also be that the chemical composition of the non-liquid antisep described as subcompartments when there is more than tic composition may be more stable, potent or otherwise one per glove, may be microscopic in size or could have more suitable when some of the components of the dimensions almost as large as the thickness of the glove composition are physically stored separately in the wall. Conceivably the pores in the spongy wall could be glove from the other substances of the antiseptic com as small as a few microns in diameter (a few millionths position until as needed, namely when the glove wall 10 of a meter). The non-liquid antiseptic composition may may be punctured or otherwise damaged. Thus, any of be added before, as, or after the spongy wall is formed the forementioned liquid or solid substances that may be into its final form. used in the non-liquid antiseptic composition may be When the antiseptic composition is added before the separately stored in the present invention; for example sponge has cured to a solid spongy matrix, the number an antiseptic, a liquid, a viscosity modifying polymer, an 15 and size of spongy compartments storing the antiseptic algesic, a colorant, a vasoconstrictor, or any of other composition can be adjusted by varying the degree of components or substances that may comprise the non mechanical agitation or ultrasonic energy applied, the liquid antiseptic composition can be stored in separate temperature, or the amount of gas injected into the compartments or locations within the glove wall as batch and subsequently removed by vacuum to form the deemed desirable. Separate locations for the substances 20 foam sponge. The ratio of open to closed subcompart in the glove may for example be useful for enhancing ments in the glove can be increased by gradual empiri the storage life of the glove, may increase antiseptic cal reduction of the ambient pressure to the hardening potency, may increase the antiseptic breadth of spec gloves. As the pressure falls and expands the subcom trum of antiseptic action, may lower the cost of manu partments, the walls between neighboring subcompart facture, may permit the glove wall to have different, 25 ments can randomly pop open at their thinnest/weakest variable or regional flexibility properties or may allow points and can remain open to each other. Alterna the use of some substances in the antiseptic compostion tively, elevated pressure can be used to minimize the which otherwise might not be possible. In the event of size of the open compartments and their interconnect a puncture, the glove wall puncture can be useful as a edness. Once the spongy glove wall has solidified or means for bringing the components of the non-liquid 30 cured the porosity of the spongy glove wall is generally antiseptic composition into contact or some state of irreversible and only the desired percent saturation of mixture particularily at the puncture hole, on the glove the glove wall with the non-liquid antiseptic composi puncturing object, on the hand or in the hand wound tion remains a optional variable to modulate. In a solid, should a wound occur, where the components may melted or vapor form (at elevated temperatures and low become mixed together and in some instances may per 35 pressures) the antiseptic composition can be added to form a chemical reaction that can form a desired non the spongy glove wall. Preferably the spongy glove has liquid antiseptic composition in part or whole; useful as a liquid impermeable coating or layer over at least the a treatment of non-liquid antiseptic composition that inner suface and outer surface of the glove wall to pre may antiseptically help the hand and the hand wound vent exposure of the hand to the non-liquid antiseptic that may have become contaminated with an infectious composition, to minimize the drying out of the solvated pathogen or other contaminant. compositions, and so that the glove may serve as a From a manufacturing standpoint, a plurality of par physical barrier to liquids when the glove wall is intact. allel compartments between two glove layers can be The liquid-impermeable (water-proof) coating, layer, or made by a manufacturing process that can sequentially thin film barrier may comprise one or more of the afore add the desired substances or materials to each subcom 45 mentioned structural glove wall materials, such as for partment between the glove layers. The thin compart example the material composition used to make the ment which can lie in parallel between the glove's outer spongy wall, and can be applied to the glove in any and inner layer can be further subdivided into thinner manner desired. parallel compartments; for example a three layer wall is It is another object of the present invention to pro envisioned having an upper or outer compartment and a 50 vide a glove having a plurality of structural connections lower or inner compartment that are in parallel with the that can be used to strengthen the glove wall and/or plane of the glove wall. It is envisioned that most often which can be used to significantly reconfigure compart a glove puncturing object would first pass through the ment 4 storing the non-liquid antiseptic composition outer glove layer, then pass through the outer compart into a plurality of subcompartments storing the non-liq ment, then pass through the inner compartment, and 55 uid antiseptic composition. Every subcompartment or then finally pass through the inner glove layer before only a portion/fraction of all of the subcompartments the object could contact and possibly wound the hand. may be connected to at least one other adjacent sub The motion of the glove puncturing object is capable of compartment. Such connections allow a glove to be transferring some outer compartment substances to mix capable of being massaged to optionally redistribute the to some degree with substances of the inner compart 60 non-liquid antiseptic composition in the glove wall as ment where the mixture could function as a non-liquid desired as illustrated in FIG. 2C. antiseptic composition. Alternatively for some embodiments of the present It is another object of the present invention to pro invention, each subcompartment may constitute a vide a glove having a plurality of glove layers acting as closed space. Such a glove wall structure can be used to a structural connection which reconfigures the com 65 provide gloves capable of expelling or extruding an partment storing the non-liquid antiseptic composition expanding foam or other expanding non-liquid antisep into a plurality of compartments (subcompartments) tic composition during and after a glove wall puncture. which macroscopically appear to the human eye (in a In addition, it is important to note that such gloves may 5,357,636 43 44 also be capable of generating in the local environments wound should a wound occur by an object contami of the glove puncture as well as on the surfaces of the nated with an infectious pathogen. glove-puncturing object, hand, and hand wound area Alternatively, for some embodiments of the present should a wound occur, a gaseous antiseptic or other invention, a peroxide chemical compound may be used chemical antiseptic; useful as an antiseptic treatment to to produce a gas. Examples of sutable peroxides include a hand and a hand wound. but are not limited to the following examples: (a) hydro For example, for some embodiments of the present gen peroxide; (b) magnesium peroxide or sodium perOX invention, the expulsion of a non-liquid antiseptic com ide (metal peroxides); or (c) benzoyl peroxide or succi position from some of the subcompartments can be nyl peroxide (organic peroxides); and mixtures thereof. automatically triggered. A glove puncture through 10 The liquid solvent for the peroxide would be water several subcompartments of the glove wall can be de when hydrogen peroxide, benzoyl peroxide or succinyl signed to anticipate a passive combination and mixing of peroxide is employed. The liquid solvent, diluent, or some of the non-liquid antiseptic components from the suspending agent would be an anhydrous oil or non damaged subcompartments. The combination and mix reactive organic fluid when a metal peroxide is em ing of the components can cause a physical or chemical 15 ployed due to the instability of these compounds in reaction therein that may be capable of generating a water. A peroxide stabilizing additive may be included positive pressure between normal atmospheric pressure with the peroxide to prolong the stability of the perox and up to about three times atmospheric pressure; useful ide during glove storage before glove use. Subcompart as an automatic means for forcing the expulsion of non ments adjacent to the subcompartment(s) containing the liquid antiseptic composition from the punctured sub 20 peroxide may store the other components of the non compartments during the glove puncture by an object liquid antiseptic composition such as for example a and thereafter for a period of time. More specifically for powdered metal oxide catalyst capable of safely cata example, some of the subcompartments may contain lyzing rapid chemical decomposition of the peroxide one of the commonly used mineral or organic acids in a into oxygen gas. The catalyst may be manganese diox 25 ide, other finely powdered metals and metal oxides or liquid solution form, at a acid concentration of between any suitable chemical agent that is capable of suitably about 0.5 percent and about 100 percent; water would and safely decomposing a peroxide during chemical be the principal liquid diluent in the solution. Suitable contact with it. The contact of the peroxide with the acids for the above purpose would include the follow catalyst is useful as a means for generating gas bubbles ing: hydrochloric acid, sulfuric acid, phosphoric acid, 30 in the non-liquid antiseptic composition; the gas produc acetic acid, formic acid, propionic acid, lactic acid, and tion is useful as a means for altering the ambient gas the like. Alternatively, the acid may be a dicarboxylic pressure of the mixture so that the local mixture ex or tricarboxylic acid such as oxalic acid, succinic acid, pands as a foaming mixture from the glove wall punc malic acid, maleic acid, citric acid, tartaric acid, ma ture site. The foaming mixture can exit from the glove lonic acid and the like. The physical state of the acid is 35 wall onto the hand and into hand wound as a foam, gel, not critical so long as the chemical is capable of provid paste or creme of non-liquid antiseptic composition ing protons to the remainder of the non-liquid antiseptic which can be useful as a non-liquid antiseptic composi composition when mixing occurs as a result of a glove tion treatment to the hand and the hand wound should wall puncture. The remaining components of the non a wound occur. In addition, the high oxygen partial liquid antiseptic composition would include a gas pressure in the mixture may provide antiseptic acitivity. releasing base such as for example a bicarbonate com A more than a 3 percent hydrogen peroxide solution pound that can be situated in glove wall subcompart may be used so that the final concentration of peroxide ments adjacent to the subcompartments containing the in the extruded non-liquid antiseptic composition is at acid. Bicarbonate chemicals are capable of producing least 3 percent. A 3 to 30 percent hydrogen peroxide carbon dioxide gas when contacted by an acid. Carbon 45 concentration is known to have useful antiseptic activ ate base compounds are also suitable although more ity. Well known combinations of metals with the fore acid is required: sodium carbonate, potassium carbon mentioned acids can also produce hydrogen gas which ate, calcium carbonate, magnesium carbonate, stron can be used for the present invention to gas pressurize tium carbonate, barium carbonate, choline carbonate, the non-liquid antiseptic composition as well. For some ditetramethyammonium carbonate, ditetraethylam 50 glove uses, a nonflammable gas such as carbon dioxide monium carbonate, propylene carbonate, butylene car may be most preferable. bonate and other nontoxic carbonate compounds may Alternatively, for some embodiments of the present be used. Combinations which may generate toxic salts invention, the combination of the subcompartment ma such as barium chloride or strontium chloride should be terials occurring during a glove puncture can be used to avoided. The simple combination of the acid and gas 55 produce an antiseptic in a more suitable or potent form. producing base chemicals is capable of generating vari For example, the mixing of glove subcompartments ous sized and various amounts of gas bubbles of carbon may be used as a means for locally activating/releasing dioxide gas in the non-liquid antiseptic composition a suitable amount of a halogen-containing antiseptic depending upon the substances present to stabilize the chemical. For example, a chlorine containing com bubbles formed. In any case the gas production in the pound such as sodium hypochlorite can be brought into glove wall can provide a means for pressurizing the contact with a liquid acid such as hydrochloric acid to non-liquid antiseptic composition to cause it to expand form a non-liquid (foam, paste, or gel) antiseptic compo in the vicinity of the glove wall puncture site and to sition containing suitable amounts of hypochlorous become actively expelled wherever possible from the acid, chlorine dioxide, and chlorine gas; these chemicals glove wall puncture hole onto the hand and into hand 65 are known to be rapidly acting, potent antiseptics. The wound as a non-liquid foam or semi-gelatinous or expulsion of this non-liquid antiseptic composition from creamy paste; useful as a prophylactic non-liquid anti a glove puncture optionally can be further facilitated by septic composition treatment to the hand and the hand adding a carbon dioxide gas generating system which is 5,357,636 45 46 also activated by the glove wall puncture; useful as an acceptable, including a design that incorporates a rein extrusion means for a foam, gel, paste or other type of forced area within the glove to withstand the internal non-liquid antiseptic composition to help to provide an and external pressures that may arise during reservoir antiseptic treatment to the hand and hand wound. massage. There may be a conduit(s) with a one-way or For some embodiments of the present invention, simi “flapper' valve between the reservoir(s) and compart lar to the forementioned approach, some subcompart ment 4 of the glove; useful to maintain the massage ments may contain an alcohol/water solution of ele pressure gradients arising in the glove to help to direct mental iodine with an iodide salt, and optionally a bicar and maintain the outward expulsion of the non-liquid bonate base compound, while other adjacent subcom antiseptic composition from the glove; the object of the partments contain a liquid acid solution. Saturated solu O additional reservoir(s) is to provide additional means for tions of elemental iodine and a iodide salt may be used increasing the expulsion of non-liquid antiseptic compo in aqueous solutions containing 25 to 95 percent of a sition from compartment 4 of the glove when the glove suitable alcohol. Preferably about 70 to 90 parts of an wall has been punctured, so that sufficient antiseptic can alcohol, preferably ethanol or isopropanol, is used with be tranferred to wherever it is thought to be needed on 10 to 30 parts of water and 0.1 to 5 parts of elemental 15 the hand. iodide and 0.1 to 10 parts of sodium iodide. When a The embodiments of the present invention that are glove puncture by an object brings the contents of sev illustrated below may include details for making the eral subcompartment together into contact by some non-liquid antiseptic composition on a small scale and mixture, acidified and reactive iodide compounds use glass beaker containers. Metal or porcelain contain which are formed as a result including HOI (hypoio 20 ers may be used instead of glass beakers when the pres dous acid) and HI(hydriodic acid) from the reaction of ent invention is mass produced. Furthermore, the order water with I2 (elemental iodine) can have rapid potent of the combination of substances used to produce the antiseptic activity. The iodide anion (I) in the mixture present invention is not limited to methods or order of can react with 12 to form I3; and is known to be useful manufacture described herein. The illustrated embodi for forming a soluble complex form of iodine as a rese 25 ments are therefore not limiting examples and only voir of I2 in solution. Optionally the mixture may also provide an illustration of useful methods for producing contain a gas-producing system to produce a gas capa the present invention. ble of forming a foam to extrude the non-liquid (foam, The antiseptic composition stored within the glove gel, paste or other non-liquid forms) of the antiseptic wall compartment(s) or subcompartments may be a composition from the glove puncture onto the hand and 30 non-liquid, or the antiseptic composition may be capa into the hand wound should a wound occur; useful as an ble of forming a non-liquid antiseptic composition when relatively immediate antiseptic treatment. an object punctures a glove wall of the present inven Another embodiment of the present invention is a tion. In the latter case, the components of the complete glove wherein only a portion of the subcompartments non-liquid antiseptic composition may be designed to of the glove are closed and wherein a portion of the 35 become suitably mixed together during a glove wall subcompartments are open so that a suitable combina puncture by an object. In this latter case, the compo tion of the forementioned protective antiseptic pro nents can be liquid(s) or non-liquid(s) or mixtures cesses and systems can be automatically and/or manu thereof. ally acted upon at the discretion of the glove wearer. Automatic assembly of the components of the anti According to another embodiment of the present septic composition into a non-liquid mixture during or invention, the compartment of the glove storing non following glove puncture is a useful object for some liquid antiseptic composition is connected to one or embodiments of the present invention. The non-liquid more additional reservoir(s) of non-liquid antiseptic antiseptic components may be assembled to form a suit composition which optionally can be opened to release able non-liquid mixture on a portion of a surface of the their contents. Accordingly a reservoir may be incorpo 45 glove-puncturing object, around the glove wall punc rated by design anywhere on the glove. Preferably an ture hole, on the hand underneath the glove wall punc additional reservoir of non-liquid (foam, gel, or paste) ture hole, or in a hand wound should a wound occur. antiseptic composition would be positioned on the prox The mixture can help to provide a non-liquid antiseptic imal (wrist) region of the glove. In some embodiments composition capable of helping to destroy infectious of the present invention, the additional reservoir(s) may 50 pathogens that the glove-puncturing object may have each store only small quanities of the antiseptic compo been carried to the glove, hand or hand wound. sition; for example at most 0.1 milliliters of non-liquid Many embodiments of the present invention are envi antiseptic composition. For other embodiments of the sioned. In general, flexible protective medical gloves of present invention, the additional reservoir(s) may retain the present invention can be designed to help to provide up to about 25 milliliters of non-liquid antiseptic compo 55 specific protection from a particular infectious patho sition. A reservoir may be of a semi-spherical (dome) gen or can be designed to help to provide a broad spec shape, an annular shape, a semi-annular design or of any trum of antiseptic activity against infectious pathogens. useful shape provided that it can provide a manually Gloves of varying size, wall thickness, compartmenta accessible reservoir of non-liquid antiseptic composition tion and flexibility can be designed for specific or gen upon demand as needed for the hand and for a hand eral glove wear needs. wound should one occur. In the event of hand wound In another embodiment of the present invention, a ing, the reservoir(s) may be massaged, pushed, rolled glove in accordance with the present invention contains forward, forced down on a firm surface, or pressurized a non-liquid antiseptic composition which comprises: by any other means to expell the non-liquid antiseptic (a) about 0.02 to about 25 parts of povidone-iodine; composition from each reservoir into the compart 65 (b) about 0.02 to about 2.5 parts of methylparaben; ment(s) of the glove wall and from there to the hand (c) about 0.01 to about 1.5 parts of propylparaben; wound site. Any means of resevoir massage would be (d) about 5 to about 15 parts sodium lauryl sulfate; also useful. Any conceivable reservoir design may be (e) about 20 to 120 parts of propylene glycol; 5,357,636 47 48 (f) about 100 to 300 parts of stearyl alcohol; (d) about 0.05 to about 30 parts of a polyoxyethylene (g) about 100 to 300 parts of a petrolatum; glycol of between about 1540 to about 6000 molecu (h) about 100 to 400 parts of sterile water; and lar weight; (i) about 25 to about 250 parts of an alcohol selected (e) about 1 to about 5 parts of sorbitan monopalmitate from the group consisting of ethanol, isopropanol, 5 (SPAN 40); and propanol, butanol, sec-butanol, tert-butanol, benzyl (f) about 0.1 to about 90 parts of an alcohol, the alcohol alcohol, methanol, cetyl alcohol, and mixtures selected from the group consisting of ethanol, isopro thereof. panol, propanol, n-butanol, sec-butanol, tert-butanol, To make the above composition in a non-liquid state, benzyl alcohol, methanol, and mixtures thereof. first the stearyl alcohol and petrolatum can be heated in 10 To form the above composition, the polyoxyethylene a glassbeaker on a steam bath to about 75° C. The other glycols and SPAN 40 together in a glass beaker water ingredients previously dissolved in the water, can then can be warmed in a water bath at 70° C. After combin be added with mixing at a temperature of 75° C. One or ing the remaining ingredients with the water and heat more milliliters of the composition may be added to fill ing them to 70° C., the ingredients may then be added to a glove compartment before the composition congeals. 15 the polyoxyethylene mixture with mixing. One or more In another embodiment of the present invention a milliliters of the composition may then be used to fill a glove in accordance with the present invention contains glove compartment before the composition congeals. a non-liquid antiseptic composition which comprises: In another embodiment of the present invention a (a) about 0.02 to about 20 parts of povidone-iodine; glove in accordance with the present invention contains (b) about 0.1 to about 90 parts of water; 20 (c) about 0.05 to about 30 parts of a polyoxyethylene a non-liquid antiseptic composition which comprises: glycol of between about 150 to about 1540 molecular (a) about 0.02 to about 20 parts of povidone-iodine; weight; (b) about 0.1 to about 90 parts of cetyl alchol; (d) about 0.05 to about 30 parts of a polyoxyethylene (c) about 1 to 10 parts of a wax; glycol of between about 1540 to about 6000 molecu 25 (d) about 5 to about 20 parts of propylene glycol; lar weight; and (e) about 0.1 to about 4 parts of sodium lauryl sulfate; (e) about 0.1 to about 90 parts of an alcohol, the alcohol and Selected from the group consisting of ethanol, isopro (e) about 10 to 80 parts of sterile water. panol, propanol, n-butanol, sec-butanol, tert-butanol, To make the above composition, the cetyl alcohol and benzyl alcohol, methanol, cetyl alcohol, stearyl alco 30 wax in the propylene glycol in a glass beaker can be hol, and mixtures thereof. melted on a water bath heated to 65 C. The sodium To make the above composition in a congealing form, lauryl sulfate can be dissolved in the water and povi the two polyoxyethylene glycole can be heated in a done-iodine in a glass beaker which is heated to 65 C. glass beaker on a steam bath to about 65 C. The other The oily liquid may then be added slowly to the water ingredients and antiseptic can then be added with mix 35 while the water is being well stirred. Stir the mixture for ing, previously dissolved in the water and at a tempera an additional 15 minutes or until good mixing has been ture of 65° C. One or more milliliters of the composition achieved. One or more milliliters of the composition may be added to fill a glove compartment before the may be added to fill a glove compartment before the composition congeals. composition congeals. In another embodiment of the present invention a In another embodiment of the present invention a glove in accordance with the present invention contains glove in accordance with the present invention contains a non-liquid antiseptic composition which comprises: a non-liquid antiseptic composition which comprises: (a) about 0.02 to about 20 parts of povidone-iodine; (a) about 0.02 to about 20 parts of povidone-iodine; (b) about 0.1 to about 90 parts of water; (b) about 0.1 to about 45 parts of cetyl alcohol; (c) about 0.05 to about 30 parts of cholesterol; 45 (c) about 1 to about 40 parts of mineral oil; (d) about 0.05 to about 30 parts of stearyl alcohol; (d) about 3 to about 27 parts of a petrolatum; (e) about 10 to 100 parts of a wax; (e) about 0.1 to about 5 parts of sodium lauryl sulfate; (f) about 500 to about 1000 parts petrolatum; and and (g) about 0.1 to about 300 parts of an alcohol selected (f) about 7 to about 60 parts of sterile water. from the group consisting of ethanol, isopropanol, 50 To make the above composition, the cetyl alcohol can propanol, n-butanol, sec-butanol, tert-butanol, benzyl be melted in a beaker over a water bath, and then the alcohol, methanol, cetyl alcohol, and mixtures sodium lauryl sulfate can be added while mixing well. thereof. The petrolatum and mineral oil can be added while To form the above composition, the stearyl alcohol, heating so that the mixture melts completely and allow wax, and petrolatum can be melted on a steam bath and 55 to cool to 23 C. Combine the water and povidone-io the cholesterol can then be added. The remaining ingre dine to make a solution at 23 C. in a beaker and then dients can be combined and heated on a steam bath and this aqueous solution can be added slowly with constant then added with mixing. One or more milliliters of the mixing to the cooled petrolatum composition. One or composition may be added to fill a glove compartment more milliliters of the composition may be added to fill before the composition congeals. a glove compartment. In another embodiment of the present invention a In another embodiment of the present invention a glove in accordance with the present invention contains glove in accordance with the present invention contains a non-liquid antiseptic composition which comprises: a non-liquid antiseptic composition which comprises: (a) about 0.02 to about 20 parts of povidone-iodine; (a) about 0.02 to about 20 parts of povidone-iodine; (b) about 0.1 to about 90 parts of water; 65 (b) about 0.1 to about 60 parts of water; (c) about 0.05 to about 30 parts of a polyoxyethylene (c) about 0.05 to about 40 parts of a polyoxyethylene glycol of between about 150 to about 1540 molecular glycol of between about 150 to about 1540 molecular weight; weight; 5,357,636 49 50 (d) about 0.05 to about 40 parts of a polyoxyethylene vidone-iodine can be added to half of the water to be glycol of between about 1540 to about 6000 molecu used in the composition (previously heated to between lar weight; about 80° C. to about 90° C.) in a first glass beaker. The (e) about 5 to about 20 parts of 1,2,6-hexanetriol; and mixture can be mixed for 10 minutes, cooled to 10 C., (f) about 0.1 to about 20 parts of an alcohol, the alcohol and then rested for between about 6 to about 30 hours. Selected from the group consisting of ethanol, isopro In a second glass beaker, the Carbopol 934 can be dis panol, propanol, n-butanol, sec-butanol, tert-butanol, solved in the remainder of the water and the pH of the benzyl alcohol, methanol, cetyl alcohol, stearyl alco Carbopol 934 can be adjusted to between pH 6.5 and 7.5 hol, and mixtures thereof. using a dilute hydroxide base solution or other base To make the above composition, the higher molecular 10 (metal or organic). In a third glass beaker, the methyl weight polyoxyethylene can be heated with the 1,2,6- paraben can be dissolved in the propylene glycol. The hexanetriol in a glassbeaker on a water bath to between contents of the three glass beakers may then be com 60° C. and about 75 C. When they are melted, then the bined but avoid whipping air into the mixture. One or lower molecular weight polyoxyethylene glycol can be more milliliters of the composition may be added to fill added with strong mixing. Then the water, alcohol(s) 15 a glove compartment before the composition congeals. and povidone-iodine can be combined in a glass beaker In another embodiment of the present invention, a and heated to 65 C. using a steam bath. Then slowly glove in accordance with the present invention contains this solution should be added with vigorous mixing to a non-liquid antiseptic composition which comprises: the polyoxyethylene glycol/hexanetriol mixture. One (a) about 1 to about 20 parts of an antiseptic; or more milliliters of the composition may be added to 20 (b) about 1 to about 5 parts of the viscosity-modifying fill a glove compartment before the composition con agent hydroxyethylcellulose; geals. (c) sodium hydroxide or acetic acid added to titrate the In another embodiment of the present invention a composition pH to pH 4 to pH 8 as desired; glove in accordance with the present invention contains (d) about 1 to about 70 parts of glycerin as a liquid a non-liquid antiseptic composition which comprises: 25 solvent; and (a) about 0.02 to about 20 parts of povidone-iodine; (e) about 1 to about 25 parts of delta gluconolactate as (b) about 0.1 to about 90 parts of water; a latent acid catalyst to neutralize the hydroxyethyl (c) about 1 to about 50 parts of glycerol monostearate; cellulose. (d) about 1 to about 100 parts of glycerin; To make the above composition, the hydroxyethylcel (e) about 0.1 to about 10 parts of bentonite; and 30 lulose can be added to the antiseptic and the glycerin (f) about 0.1 to about 90 parts of an alcohol, the alcohol (previously heated to between about 50° C. to about 90 selected from the Group consisting of ethanol, iso C.) in a glassbeaker. The antiseptics which may be used propanol, propanol, n-butanol, sec-butanol, tert in this composition include but are not limited to the butanol, benzyl alcohol, methanol, cetyl alcohol, following: chlorhexidine gluconate, nonoxynol-9, and stearyl alcohol, and mixtures thereof. 35 other antiseptics that are compatible with cellulose To make the above composition, one may dissolve the polymers. The liquified mixture can be mixed for 20 povidone-iodine in the half of the water and half of the minutes and the pH adjusted to a pH between about 4 alcohol(s) (by volume) in a glass beaker and then care and about 8; preferably to about pH 4 to about 6; most fully lay the bentonite on the water's surface to allow it preferably to a pH of about 4.5. After 30 minutes of to self-wet. One may then stir the mixture until a uni mixing, the delta gluconolactone may be added. After form magma is produced. Melt the glycerol monostea an additional 30 minutes, the hot liquid mixture pH can rate in the glycerin in another beaker on a steam bath. be adjusted further if needed. One or mope millilters of Heat the bentonite magma to the same temperature as the composition may be added to fill a glove compart the glycerols, and combine the two liquids with stirring. ment before the composition congeals at lower temper One may then add the remaining water and alcohol 45 taures. This gel composition can be useful in latex while stirring. One or more milliliters of the composi gloves when rubber wall softening or weakening may tion may be added to fill a glove compartment before be a design concern. the composition congeals. In another embodiment of the present invention a In another embodiment of the present invention a glove in accordance with the present invention contains glove in accordance with the present invention contains 50 a non-liquid antiseptic composition which comprises: a non-liquid antiseptic composition which comprises: (a) about 0.02 to about 20 parts of povidone-iodine; (a) about 0.02 to about 20 parts of povidone-iodine; (b) about 0.1 to about 90 parts of water; (b) about 0.1 to about 90 parts of water; (c) about 1 to about 50 parts of glycerol monostearate; (c) about 0.1 to 5 parts of a methylcellulose (such as for (d) about 1 to about 100 parts of glycerin; example, a hydroxypropylmethyl cellulose such as 55 (e) about 0.1 to about 10 parts of bentonite; and Methocel 60 HG, Methocel 70 HG, Methocel 90 HG (e) about 0.1 to about 90 parts of an alcohol, the alcohol and the like-available for example from Dow Cor selected from the group consisting of ethanol, isopro ning Chemical Co.) or a hydroxyethyl cellulose (such panol, propanol, n-butanol, sec-butanol, tert-butanol, as for example, Cellosize-available from The Car benzyl alcohol, methanol, cetyl alcohol, stearyl alco bide & Carbon Chemicals Corp.); hol, and mixtures thereof. (d) about 0.01 to about 3 parts of Carbopol 934-availa The bentonite can be sprinkled on top of about two ble from B.F. Goodrich Chemical Co. and/or the like thirds of the water heated to about 60° C. and allowed polymers; to become wet. With mixing a uniform magma can be (e) about 0.01 to 2 parts of methylparaben (or another made. The glycerol monostearate can be melted at paraben); and 65 about 60° C. in the glycerin heated on a water bath and (f) 0.1 to about 20 parts of propylene glycol. then added to the magma at preferably the same temper To make the above composition, the methyl- or hydrox ature. The mixture can be stirred as it cools and the yethyl- or hydroxypropylmethyl-cellulose and the po remainder of the water can be added. One or more 5,357,636 51 52 milliliters of the composition may be added to fill a The calcium citrate can be dissolved with the methyl glove compartment before the composition has con paraben in the water. The glycerin and alcohol can be gealed. mixed with the sodium alginate to form a smooth paste. In another embodiment of the present invention a The aqueous solution can be mixed into the paste and glove in accordance with the present invention contains 5 stirred till stiffening begins. One or more milliliters of a non-liquid antiseptic composition which comprises: the composition may be added to fill a glove compart (a) about 0.02 to about 20 parts of povidone-iodine; ment before the composition fully stiffens. Stiffening (b) about 0.1 to about 40 parts of water; may take several hours. (c) about 0.05 to about 30 parts of a polyoxyethylene Instead of using the antiseptic povidone-iodine in the glycol of between about 150 to about 1540 molecular O above formulated embodiments of the present inven weight; tion, another antiseptic may be used above in its place or (d) about 5 to about 40 parts of a polyoxyethylene gly optionally, a combination of two or more antiseptics col of between about 1540 to about 6000 molecular may be used instead of povidone-iodine in the above weight; and formulated embodiments of the present invention. Op (e) about 0.1 to about 90 parts of cetyl alcohol or stearyl 15 tionally the same antiseptic parts range as provided alcohol and mixtures thereof. above may be used. Futhermore, optionally, the above To make the above composition in a congealing form, embodiments of the present invention may be made and the two polyoxyethylene glycols can be heated in a used without including an alcohol in the antiseptic con glass beaker on a steam bath to about 75 C. The other position. ingredients can then be added with mixing, previously In another embodiment of the present invention a dissolved in the water and at a temperature of 65° C. glove in accordance with the present invention contains One or more milliliters of the composition may be a non-liquid antiseptic composition which comprises: added to fill a glove compartment before the composi (a) about 0.1 to about 25 parts of sodium hypochlorite; tion congeals. It is possible to incorporate water or (b) about 50 to 99 parts of water; aqueous solutions to the extent of 20% or alcoholic 25 (c) about 0.05 to about 30 parts of a polyoxyethylene solutions not exceeeding 5% of the total formula. The glycol of between about 150 to about 1540 molecular inclusion of a small percentage of cetyl alcohol or stea weight; ryl alcohol tends to inhibit the solubilizing effects of (d) about 0.05 to about 30 parts of a polyoxyethylene water, alcohol, or organic acids on the carbowax glycol of between about 1540 to about 6000 molecu polyethylene glycol mixtures. (See Remington's Phar 30 lar weight; and maceutical Sciences, 13th edition (1965) page 533-534) (e) about 0.1 to about 90 parts of an alcohol, the alcohol In another embodiment of the present invention a selected from the group consisting of ethanol, isopro glove in accordance with the present invention contains panol, propanol, n-butanol, sec-butanol, tert-butanol, a non-liquid antiseptic composition which comprises: benzyl alcohol, methanol, stearyl alcohol, cetyl alco (a) about 0.02 to about 20 parts of povidone-iodine; 35 hol, and mixtures thereof. (b) about 0.1 to about 10 parts of water; To make the above composition in a congealing form, (c) about 0.05 to about 30 parts of a polyoxyethylene the two polyoxyethylene glycols can be heated in a glycol of between about 150 to about 1540 molecular glass beaker on a steam bath to about 65 C. The other weight; ingredients and antiseptic can then be added with mix (d) about 5 to about 40 parts of a polyoxyethylene gly ing, previously dissolved in the water and at a tempera col of between about 1540 to about 6000 molecular ture of 85°C. One or more milliliters of the composition weight; and may be added to fill a glove compartment before the (e) about 0.1 to about 30 parts of polyethylene glycol composition congeals. 400 monostearate. In another embodiment of the present invention a To make the above composition in a congealing form, 45 glove in accordance with the present invention contains the two polyoxyethylene glycols can be melted to a non-liquid antiseptic composition which comprises: gether in a glass beaker on a steam bath to about 70° C. (a) about 0.1 to about 25 parts of chlorhexidine gluco and mixed while allowing the mixture to cool to about nate; 45 °C. In a second container, the polyethylene glycol (b) about 0.1 to about 90 parts of water; 400 monostearate can be melted at about 45 C. and the 50 (c) about 0.05 to about 30 parts of a polyoxyethylene other ingredients can then be added with mixing till a glycol of between about 150 to about 1540 molecular smooth mixture is obtained. The two mixtures can then weight; be combined at about 45 C. and stirred until an oint (d) about 0.05 to about 30 parts of a polyoxyethylene ment is obtained. One or more milliliters of the compo glycol of between about 1540 to about 6000 molecu sition may be added to fill a glove compartment before 55 lar weight; and the composition congeals. (e) about 0.1 to about 90 parts of an alcohol, the alcohol In another embodiment of the present invention a selected from the group consisting of ethanol, isopro glove in accordance with the present invention contains panol, propanol, n-butanol, sec-butanol, tert-butanol, a non-liquid antiseptic composition which comprises: benzyl alcohol, methanol, stearyl alcohol, cetyl alco (a) about 0.1 to about 20 parts of povidone-iodine; hol, and mixtures thereof. (b) about 0.01 to about 0.1 parts of calcium citrate; To make the above composition in a congealing form, (c) about 1 to about 6 parts of sodium alginate; the two polyoxyethylene glycols can be heated in a (d) about 0.01 to about 1 part of methylparaben; glass beaker on a steam bath to about 65 C. The other (e) about 1 to about 60 parts of glycerin; ingredients and antiseptic can then be added with mix (f) about 1 to about 50 parts of water; and 65 ing, previously dissolved in the water and at a tempera (g) about 1 to about 50 parts of an alcohol selected from ture of 65° C. One or more milliliters of the composition the group consisting of methanol, ethanol, isopropa may be added to fill a glove compartment before the nol, propanol, and mixtures thereof. composition congeals. 5,357,636 53 54 In another embodiment of the present invention a congeal into an ointment base. The iodine and potas glove in accordance with the present invention contains sium iodine are dissolved in the glycerin and alcohol at a non-liquid antiseptic composition which comprises: a temperature below 70° C. and then cooled to the same (a) about 0.1 to about 50 parts of nonoxynol-9; temperature as the ointment. The antiseptic solution is (b) about 0.1 to about 95 parts of water; then mixed into the ointment base using a slow speed (c) about 0.05 to about 30 parts of a polyoxyethylene (10-120 revolutions per minute mechanical paddle) and glycol of between about 150 to about 1540 molecular then allowed to cool slowly. One or more milliliters of weight; - the composition may be added to fill a glove compart (d) about 0.05 to about 30 parts of a polyoxyethylene ment before the composition congeals. glycol of between about 1540 to about 6000 molecu 10 In another embodiment of the present invention a lar weight; and glove in accordance with the present invention contains (e) about 0.1 to about 90 parts of an alcohol, the alcohol a non-liquid antiseptic composition which comprises: selected from the group consisting of ethanol, isopro (a) about 0.1 to about 10 parts of mecuric red oxide; panol, propanol, n-butanol, sec-butanol, tert-butanol, (b) about 0.1 to about 8 parts of petrolatum; benzyl alcohol, methanol, stearyl alcohol, cetyl alco 15 hol, and mixtures thereof. (c) about 0.1 to about 40 parts of wool fat; and To make the above composition in a congealing form, (d) about 0.05 to about 23 parts of yellow wax. the two polyoxyethylene glycols can be heated in a To make the above composition in a congealing form, glass beaker on a steam bath to about 65 C. The other the mecuric red oxide antiseptic can be blended in the ingredients and antiseptic can then be added with mix 20 petrolatum after it has been melted on a steam bath. ing, previously dissolved in the water and at a tempera During continued heating and stirring, the wool fat and ture of 65C. One or more milliliters of the composition yellow wax are then added until a smooth blend is ob may be added to fill a glove compartment before the tained. One or more milliliters of the composition may composition congeals. be added to fill a glove compartment before the compo The preferred embodiment of the present invention is 25 sition congeals. a glove in accordance with the present invention which In another embodiment of the present invention a contains a non-liquid antiseptic composition which glove in accordance with the present invention has at comprises: least two compartments in parallel to the glove wall, (a) about 0.1 to about 16 parts of elemental iodine; wherein at least one of the compartments parallel to the (b) about 0.1 to about 16 parts of potassium iodide; 30 glove wall, called compartment A, contains an acidic (c) about 0.1 to about 25 parts of water; solution which comprises: (d) about 0.05 to about 30 parts of a polyoxyethylene (a) about 0.1 to about 50 parts of a 1 to 30 percent aque glycol of between about 150 to about 1540 molecular ous solution of a mineral acid, organic acid, or of a weight; buffered mixture of relatively acidic salts; (e) about 0.05 to about 30 parts of a polyoxyethylene 35 (b) about 0.1 to about 90 parts of an alcohol, the alcohol glycol of between about 1540 to about 6000 molecu selected from the group consisting of ethanol, isopro lar weight; panol, propanol, n-butanol, sec-butanol, tert-butanol, (f) about 0.1 to about 50 parts of glycerin; and benzyl alcohol, methanol, stearyl alcohol, cetyl alco (g) about 0.1 to about 75 parts of an alcohol, the alcohol hol, and mixtures thereof; selected from the group consisting of ethanol, isopro (c) about 0.05 to 5 parts of a surface-active agent or a panol, propanol, n-butanol, sec-butanol, tert-butanol, detergent; benzyl alcohol, methanol, stearyl alcohol, cetyl alco and wherein at least one of the other compartments, hol, and mixtures thereof. called compartment B, that is parallel to the glove wall To make the above composition in a congealing form, and to compartment A, contains an antiseptic composi the two polyoxyethylene glycols can be heated in a 45 tion which comprises: glass beaker on a steam bath to about 65 C. The other (a) about 0.1 to about 50 parts of an antiseptic, other ingredients and antiseptic can then be added with mix than an organic acid, a mineral acid, or a buffered ing, previously dissolved in the water and at a tempera mixture of relatively acidic salts; ture of 65C. One or more milliliters of the composition (b) about 0.1 to about 95 parts of water; may be added to fill a glove compartment before the 50 (c) about 0.05 to about 30 parts of a polyoxyethylene composition congeals. glycol of between about 150 to about 1540 molecular In another embodiment of the present invention a weight; glove in accordance with the present invention contains (d) about 0.05 to about 30 parts of a polyoxyethylene a non-liquid antiseptic composition which comprises: glycol of between about 1540 to about 6000 molecu (a) about 0.1 to about 16 parts of elemental iodine; 55 lar weight; and (b) about 0.1 to about 16 parts of potassium iodide; (e) about 0.1 to about 90 parts of an alcohol, the alcohol (c) about 0.1 to about 30 parts of yellow wax; selected from the group consisting of ethanol, isopro (d) about 0.1 to about 22 parts of wool fat; panol, propanol, n-butanol, sec-butanol, tert-butanol, (e) about 5 to about 80 parts of petrolatum; benzyl alcohol, methanol, stearyl alcohol, cetyl alco (f) about 0.1 to about 50 parts of Glycerin; and 60 hol, and mixtures thereof; (g) about 0.1 to about 40 parts of an alcohol, the alcohol (f) about 0.05 to about 10 parts of a surface-active agent selected from the group consisting of ethanol, isopro or a detergent; panol, propanol, n-butanol, sec-butanol, tert-butanol, (g) about 0.1 to about 50 parts of a bicarbonate salt or a benzyl alcohol, methanol, stearyl alcohol, cetyl alco carbonate salt capable of releasing some carbon diox hol, and mixtures thereof. 65 ide gas upon exposure of the salt to an acid, or about To make the above composition in a congealed form, 0.1 to about 50 parts of a fine metal powder, including the yellow wax, wool fat and petrolatum may be melted for example magnesium, zinc, or another suitable together on a steam bath and then allowed begin to metal that is capable of producing some hydrogen gas 5,357,636 55 56 upon contact of the metal powder grains with an glove wall, called compartment One, contains a cata acid; lytic solution which comprises: and wherein contact between the acidic solution and (a) about 0.1 to about 30 parts of a peroxide compound; the antiseptic composition, which may arise as a result (b) about 1 to about 40 parts of deionized water; of a glove wall puncture by an object, can provide at 5 (c) about 0.1 to about 10 parts of a multivalent cation least some combinational mixing of the substances of complexation agent such as EDTA, HEDTA, compartments A and B of the glove, the mixture capa EGTA or the like; ble of forming some expanding non-liquid antiseptic (d) about 0.05 to about 10 parts of a pH buffer to adjust composition, which can appear to be foamy or creamy, the pH of the composition in compartment C pH to the expanding property of the composition rendering O between pH 7 and 8 or to a pH range where a metal the composition to be capable of some self-expulsion complexation agent is soluble; from a glove wall puncture and some transfer onto the (e) about 0.05 to 5 parts of a surface-active agent or hand or into a hand wound should a wound be caused detergent; by the object during the glove wall puncture. and wherein at least one of the other compartments, The acidic substances used in compartment A can be 15 called compartment Two, that is parallel to the glove mixed together at room temperature and may be poured wall and to compartment One, contains an antiseptic into compartment A which can be sealed to prevent its composition which comprises: leakage. To prepare the antiseptic composition for com (a) about 0.1 to about 50 parts of an antiseptic other than partment B, the two polyoxyethylene glycols can be a peroxide; heated in a glass beaker on a steam bath to about 65° C. 20 (b) about 0.1 to about 95 parts of water; In a second container the other ingredients and antisep (c) about 0.05 to about 30 parts of a polyoxyethylene tic(s) are dissolved in the water, heated to a temperature glycol of between about 150 to about 1540 molecular of 65° C., and then can be added with mixing to the weight; liquified mixture of polyoxyethylene glycols. While the (d) about 0.05 to about 30 parts of a polyoxyethylene 25 glycol of between about 1540 to about 6000 molecu complete compartment B composition is still liquified, it lar weight; and is added to compartment B. At the same time or after (e) about 0.1 to about 90 parts of an alcohol, the alcohol cooling to room temperature, compartment B should be selected from the group consisting of ethanol, isopro sealed to avoid leakage. panol, propanol, n-butanol, sec-butanol, tert-butanol, Contact between the compartment A and compart 30 benzyl alcohol, methanol, stearyl alcohol, cetyl alco ment B compositions during glove manufacture should hol, and mixtures thereof; be avoided to avoid premature formation of the expand (f) about 0.05 to about 10 parts of a surface-active agent able non-liquid antiseptic composition. In addition, or a detergent; when halogen-containing antiseptics or a halide salt are (g) about 0.1 to about 20 parts of a peroxide catalyst used in the above embodiment of the present invention, 35 such as a powdered catalytic metal or a catalytic contact between acid from compartment A and a halo metal compound such as a metal oxide like for exam gen-containing antiseptic or halide salt from compart ple maganese dioxide; useful becuase the peroxide ment B may produce a halogen gas. For example, if catalyst is capable of releasing oxygen gas from a compartment B contains a hypochlorite salt such as peroxide compound; sodium hypochlorite and it is contacted by an acid such 40 (h) optionally about 1 to 25 parts of an organic acid, a as hydrochloric acid, then some chlorine gas will mineral acid, or a buffered mixture of relatively evolve. For some embodiments of the present inven acidic salts or a mixture thereof, useful to inactivate tion, suitable small amounts of halogen gas can be pro the cation complexation agent which may be present vided by the present invention at the glove puncture when the some of the contents from compartments site; useful as a mobile gaseous antiseptic capable of 45 One and Two mix together during glove puncture; diffusing as a gas from the glove puncture to the hand and wherein contact between the substances of com and into a hand wound. The capability to produce hy partment One and Two can provide a mixture, the mix drogen gas from metal-acid reactions should be avoided ture capable of forming an expanding non-liquid anti in a glove that can also produce a halogen gas. Hydro septic composition capable of some self-expulsion from gen-halogen reactions may be dangerous and can rap 50 the glove wall puncture and some transfer onto the idly consume the halogen gas. hand or into a hand wound should a wound be caused A hand wound may be caused by a glove puncturing by the object. object or may already exist on a hand wearing the pres The substances used in compartment One can be ent invention. In either situation, it may be beneficial to mixed together at room temperature and poured into treat the hand wound, the hand wound perimeter and 55 compartment One which should then be suitably sealed the hand with an antiseptic composition by an auto to prevent its leakage. matic means without undue delay. Some embodiments To make the composition for compartment Two, the of the present invention when worn on a hand can auto two polyoxyethylene glycols can be heated in a glass matically help to provide a treatment of a non-liquid beaker on a steam bath to about 65° C. The other ingre antiseptic composition to the hand and a hand wound dients and antiseptic(s) can then be added with mixing, near the glove puncture site without undue delay. The previously dissolved in the water and at a temperature antiseptic can help to prevent contamination of the of 65° C. While the mixture is still liquified, compart hand or hand wound with an infectious pathogen that ment Two should be filled. At the same time or after may have preexisted on the glove-puncturing object. cooling to room temperature, compartment Two In another embodiment of the present invention a 65 should be sealed to prevent its leakage. glove in accordance with the present invention has at Contact between the compartment One and compart least two compartments in parallel to the glove wall, ment Two compositions during glove manufacture wherein at least one of the compartments parallel to the must be avoided to avoid premature formation of an 5,357,636 57 58 expanding non-liquid antiseptic composition. The capa In another embodiment of the present invention a bility to produce hydrogen gas from metal-acid reac glove in accordance with the present invention contains tions should be avoided in a glove that is also capable of a non-liquid antiseptic composition which comprises: producing a halogen to avoid hydrogen-halogen reac (a) about 0.1 to about 50 parts of an antiseptic; and tions. 5 (b) about 0.1 to about 50 parts of petrolatum jelly. In another embodiment of the present invention a The above non-liquid antiseptic composition can be glove in accordance with the present invention contains formulated in a number of ways: a non-liquid antiseptic composition which comprises: (a) the antiseptic can be dispersed as an insoluble sus (a) about 0.1 to about 50 parts of an antiseptic; pension in the petrolatum jelly; (b) about 0.1 to about 95 parts of water; O (b) the antiseptic can be dissolved in petrolatum jelly; (c) about 0.05 to about 30 parts of a polyoxyethylene (c) the antiseptic can be dissolved in a substance which glycol of between about 150 to about 1540 molecular can be dissolved in the petrolatum jelly; or weight; (d) the antiseptic can be dissolved in a substance which (d) about 0.05 to about 30 parts of a polyoxyethylene is insoluble in the petrolatum jelly; glycol of between about 1540 to about 6000 molecu 15 (d) the antiseptic can be dissolved in a substance which lar weight; and can form a simple water-oil emulsion, a simple oil (e) about 0.1 to about 90 parts of an alcohol and mix water emulsion, or a complex multiple phase emul tures thereof. sion which is then mixed to form a non-liquid with To make the above antiseptic composition, the two the petrolatum jelly; polyoxyethylene glycols can be heated in a glass beaker 20 (e) or mixtures thereof. on a steam bath to about 65 C. The other ingredients In another embodiment of the present invention a and antiseptic can then be added with mixing, having glove in accordance with the present invention contains been previously dissolved in the water at a temperature a non-liquid antiseptic composition which comprises: of 65 C. About one to twenty parts of the 65° C. liqui (a) about 0.1 to about 50 parts of an antiseptic; and fied antiseptic composition can be combined with about 25 (b) about 0.1 to about 50 parts of a non-liquid medium one to thirty parts of a liquified glove wall structural which comprises: one or more materials or substances composition. Preferably the structural wall composition capable of forming a hydrated gel, an organic solvent and the antiseptic composition are selected to form a hydrated gel, another gel, a foam, a paste, an oint composite mixture in which the non-liquid antiseptic ment, a grease, a putty, a viscous cream, a viscous 30 oil-water emulsion, a viscous water-oil emulsion, a composition and the structural wall composition are multiphasic emulsion, another non-liquid medium, or poorly soluble within each other. Structural wall mate mixtures thereof. rials may be comprised of one or mope of the following: The above non-liquid antiseptic composition can be rubber materials, plastic materials, plant materials, min formulated in a number of ways in the non-liquid me eral materials, and/or animal materials. 35 dium: Before a mixture of wall structural elements and anti (a) the antiseptic can be dispersed as an insoluble sus septic composition is permited to cool and become pension in the non-liquid medium; or semi-solid, some properties of the eventual glove wall (b) the antiseptic can be dissolved in the non-liquid subcompartments storing the non-liquid antiseptic com medium; or position can be varied; their heterogeneity, their vol (c) the antiseptic can be dissolved in a substance which ume, and the degree of their interconnections of the is then dissolved in the non-liquid medium; or subcompartments can be varied by adjusting the agita (d) the antiseptic can be dissolved in a substance which tion, the viscosity, and the ambient pressure of the mix is insoluble in the non-liquid medium; or ture. Increasing the agitation of the mixture can be used (e) or mixtures thereof can be formulated; or to shear subcompartments into smaller volumes and 45 (f) the antiseptic composition of (a), (b), (c), (d) or (e) alter their interconnections. Addition of a viscosity can be capable of being combined with a gas pro modifying substance or using less liquids with the solids vided by the glove as a result of a glove wall punc in the composite mixture can be used to increase the ture, the gas-liquid or gas-liquid-solid emulsion capa viscosity of the mixture and tends to stabilize the sub ble of providing a foam or a viscous non-liquid com compartmentation and interconnections between sub 50 position. compartments. A glove in accordance with the present In general, no particular order or method of produc invention can be made for example by first making a ing the above non-liquid antiseptic composition is nec thin rubber or thin plastic glove on a hand mold. Then essary. this inner glove wall is coated by any means with a layer The preferred embodiment (See Example 1 below) of of the composite mixture of antiseptic composition and 55 the present invention is a flexible protective glove structural wall composition while it is still warm or which comprises: an inner layer 3 of polyethylene plas liquified. Increased pressure can be used to reduce the tic which is about 1 mill in thickness; an outer layer 2 of size of the compartments and reduce air bubble size in neoprene rubber which is about 4 mils in thickness; and the composite mixture layer until the layer has cooled a compartment 4 containing by volume approximately or congealed or until the structural materials in the 10 milliliters of a non-liquid gelatinous antiseptic com mixture have attained their final solid form. The solidi position comprising: 30 parts of elemental iodine, 30 fied layer of composite mixture may comprise a porous parts of potassium iodide, 50 parts of ethanol, 50 parts of spongy layer of non-liquid antiseptic composition. The distilled sterile water, 0.01 parts of FD&C red dye No. porous exterior of the spongy layer of the glove is pref 40 (#40), 60 parts of polyoxyethylene glycol of about erably sealed so that it is liquid-impermeable by apply 65 1540 grams per mole molecular weight, 60 parts of ing a thin film of a rubber, plastic or combination of polyethylene glycol of about 4000 grams per mole mo structural materials over the glove exterior by spray lecular weight, 30 parts of glycerin, and 10 parts of coating, by dipping or by other means. stearyl alcohol; wherein compartment 4 has a preferred 5,357,636 59 60 thickness ranging between about 1 mil (one-thousandth compartment 4 of the glove is sealed using a silicone of an inch) to about 250 mils and is closed to prevent containing glue mixture. evaporation. Note here that the term "parts” is a mea Sure used in the present invention that means a measure REMAINING EXAMPLES of parts by weight and not a parts by volume. Note: For the remaining Examples, similar methods The following Examples illustrate the present inven and quantities of materials are used to combine the tion. substances in the formulation of the non-liquid antisep tic composition unless specified further or otherwise in EXAMPLE 1. each Example. Each non-liquid antiseptic composition Example 1 describes how the preferred embodiment 10 in a hot liquified state is put in a compartment in a glove of the present invention is made. 60 grams of polyethyl in accordance with the glove design of Example 1 of the ene glycol 1540 molecular weight (PEG 1540) and 60 present invention, unless specified further in each Ex grams of polyethylene glycol 4000 molecular weight ample. If a dye is used in an Example then the dye is (PEG 4000) are heated to 65° C. in a glass beaker A FD&C #40 unless specified. sitting in a hot water bath until the PEG 1540 and PEG 15 4000 has melted and are evenly mixed. 50 grams of EXAMPLE 3 ethanol, 80 grams of glycerin, 10 grams of stearyl alco The gloves for Example 3 use a portion of a non-liq hol and 50 grams of distilled sterile water, 30 grams of uid antiseptic composition containing 90 grams of povi elemental iodine, 80 grams of potassium iodide, and 10 done-iodine, 405 grams of distilled sterile water and 45 milligrams of FD&C Red Dye #40 are mixed in a sec 20 ond glass beaker B heated at 65 C. in a water bath until grams of isopropyl alcohol which is suspended in 130 the mixture appears homogeneous. The contents of grams of polyoxyethylene glycol 1540 molecular beaker A and beaker B are combined and then the hot weight and 120 grams of polyoxyethylene glycol 4000 antiseptic composition is stirred for 120 minutes while molecular weight to form a gel. maintaining the temperature of the composition at 65° 25 EXAMPLE 4 C. The stirring rate is adjusted to minimize the addition of air into the mixture. An inner glove layer of 1 mil The gloves for Example 4 are elongated in length thick polyethylene plastic (second material) is formed compared to the other Glove Examples of the present and cured until dry on a first hand mold. A slightly invention from a length of 12 inches to a length of 30 larger outer glove layer of 4 mill thick white neoprene 30 inches) to include a protective arm portion that could rubber (first material) is formed and cured until dry on be extended to the shoulder and armpit. The non-liquid a second hand mold. The interior surface of the rubber antiseptic composition contain 50 grams of elemental outer glove layer is evenly coated with about 9 milli iodine, 50 grams of sodium iodide, 80 grams of distilled liters of the warm liquified antiseptic composition. sterile water, 100 grams of polyoxyethylene glycol 1540 While it is still warm, the outer glove layer is then 35 molecular weight, 100 grams of polyoxyethylene glycol slipped over the inner glove layer on the first hand 4000 molecular weight, 270 grams of isopropanol. The mold. The glove is then allowed to cool to 23 C. during antiseptic composition is kept at 60° C. until added to which time the antiseptic composition between the the glove compartment. An inner glove layer of 5 mil glove layer can gel. The end of compartment 4 of the thick polyethylene plastic (second material) is formed glove is then sealed using a silicone containing glue and cured until dry on a long-armed first hand mold. A (Archer Brand Silicone Rubber Cement, Radio Shack, slightly larger outer glove layer of 8 mill thick white Fort Worth, Tex., 76102) containing methyltriacetoxy neoprene rubber (first material) is formed and cured silane (CAS 004253343), ethyltriacetoxy-silane (CAS until dry on a long-armed second hand mold, and is then 017689779), polydimethylsiloxane, and silica (CAS evenly filled with the about 100 milliliters of the hot 007631869). 45 antiseptic composition. The outer glove layer is then slipped over the inner glove layer on the first hand mold EXAMPLE 2 and the temperature of the antiseptic composition is 200 grams of stearyl alcohol and 200 grams of petro allowed to cool so that the composition gels. The shoul latum are heated in a glass beaker on a steam bath to der arm end of compartment 4 of the glove is then melt them. To a second glass beaker on a steam bath, 1.3 50 sealed using a silicone containing glue. grams of methylparaben, 0.8 grams of propylparaben, 10grams of laurylsulfate, 70 grams of propylene glycol, EXAMPLE 5 120 grams of distilled sterile water, 120 grams of ethanol The gloves for Example 5 are made using a non-liquid and 25 grams of povidone-iodine are added and mixed antiseptic composition containing 30 grams of elemental until the solution appears to have become well mixed at 55 iodine, 30 grams of sodium iodide, 50 grams of distilled about 70° C. The contents of the second beaker are then sterile water, 60 grams of polyoxyethylene glycol 1540 added gradually to the first beaker while mixing well to molecular weight, 60 grams of polyoxyethylene glycol make the antiseptic composition. An inner glove layer 4000 molecular weight, 0.01 grams of FD&C red dye of 5 mill thick polyethylene plastic (second material) is No. 40, and 50 grams of ethanol. An inner glove layer of formed and cured until dry on a first hand mold. A 4 mil thick polyethylene plastic (second material) is slightly larger outer glove layer of 5 mill thick white formed and cured until dry on a first hand mold. A neoprene rubber (first material) is formed and cured slightly larger outer glove layer of 4 mill thick white until dry on a second hand mold, and then is evenly latex rubber (first material) is formed and cured until filled with the about 10 milliliters of the hot liquified dry on a second hand mold, and then is evenly filled antiseptic composition. The outer glove layer is then 65 with the about 10 milliliters of the antiseptic composi slipped over the inner glove layer on the first hand tion heated to a liquid state. The outer glove layer is mold. After the glove has cooled to room temperature then slipped over the inner glove layer on the first hand and the antiseptic composition has gelled, the end of mold, and after the antiseptic composition gels, the end 5,357,636 61 62 of compartment 4 of the glove is sealed using a silicone 0.01 grams of FD&C red dye No. 40, and 0.5 grams of containing glue. titanium dioxide. An inner glove layer of 1 mill thick polyethylene plastic (second material) is formed and EXAMPLE 6 cured until dry on a first hand mold. A slightly larger The gloves for Example 6 are made using a non-liquid outer glove layer of 5 mil thick white latex rubber (first antiseptic composition containing 20 grams of povi material) is formed and cured until dry on a second done-iodine, 45 grams of distilled sterile water, 15 hand mold, and then is evenly filled with the about 10 grams of cholesterol, 15 grams of stearyl alcohol, 50 milliliters of the antiseptic composition heated to a liq grams of white wax, 750 grams of petrolatum, 0.01 uid state. The outer glove layer is then slipped over the grams of FD&C red dye No. 40, and 150 grams of cetyl 10 inner glove layer on the first hand mold, and after the alcohol, and 10 milligrams of bradykinin. An inner antiseptic composition gels, the end of compartment 4 glove layer of 4 mill thick polyethylene plastic (second of the glove is sealed using a silicone containing glue. material) is formed and cured until dry on a first hand mold. A slightly larger outer glove layer of 4 mil thick EXAMPLE 10 white latex rubber (first material) is formed and cured 15 The gloves for Example 10 are made using a non-liq until dry on a second hand mold, and then is evenly uid antiseptic composition containing 10 grams of povi filled with the about 10 milliliters of the antiseptic com done-iodine, 45 grams of distilled sterile water, 25 position heated to a liquid state. The outer glove layer is grams of glycerol monostearate, 50 grams of glycerin, 5 then slipped over the inner glove layer on the first hand grams of bentonite, 45 grams of ethanol, 0.01 grams of mold, and after the antiseptic composition gels, the end 20 FD&C red dye No. 40, and 0.5 grams of titanium diox of compartment 4 of the glove is sealed using a silicone ide. An inner glove layer of 1 mil thick polyethylene containing glue. plastic (second material) is formed and cured until dry on a first hand mold. A slightly larger outer glove layer EXAMPLE 7 of 3 mil thick white polyethylene plastic (first material). The gloves for Example 7 are made using a non-liquid 25 is formed and cured until dry on a second hand mold, antiseptic composition containing 6.0 grams of sodium and then is evenly filled with the about 10 milliliters of hypochlorite, 45 grams of cetyl alcohol, 10 grams of the antiseptic composition heated to a liquid state. The white wax, 15 grams of propylene glycol, 2 grams of outer glove layer is then slipped over the inner glove sodium lauryl sulfate, 40 grams of distilled sterile water, layer on the first hand mold, and after the antiseptic 0.01 grams of FD&C red dye No. 40, and 0.5 grams of composition gels, the end of compartment 4 of the glove titanium dioxide. An inner glove layer of 4 mil thick is sealed using a silicone containing glue. polyethylene plastic (second material) is formed and cured until dry on a first hand mold. A slightly larger EXAMPLE 11 outer glove layer of 5 mill thick white latex rubber (first The gloves for Example 11 are made using a non-liq material) is formed and cured until dry on a second 35 uid antiseptic composition containing 10 grams of povi hand mold, and then is evenly filled with the about 10 done-iodine, 45 grams of distilled sterile water, 2 grams milliliters of the antiseptic composition heated to liquid of methylcellulose, 2 grams of Carbopol 934, 1 gram of state. The outer glove layer is then slipped over the methylparaben, 10 grams of propylene glycol, 0.01 inner glove layer on the first hand mold, and after the grams of FD&C red dye No. 40, and 0.5 grams of tita antiseptic composition gels, the end of compartment 4 nium dioxide. An inner glove layer of 1 mill thick poly of the glove is sealed using a silicone containing glue. ethylene plastic (second material) is formed and cured until dry on a first hand mold. A slightly larger outer EXAMPLE 8 glove layer of 4 mill thick white latex rubber (first mate The gloves for Example 8 are made using a non-liquid rial) is formed and cured until dry on a second hand antiseptic composition containing 6.0 grams of potas 45 mold, and then is evenly filled with the about 10 milli sium hypochlorite, 35 grams of cetyl alcohol, 20grams liters of the antiseptic composition heated to a liquid of mineral oil, 25 grams of petrolatum, 4 grams of so state. The outer glove layer is then slipped over the dium lauryl sulfate, 20 grams of distilled sterile water, inner glove layer on the first hand mold, and after the 0.01 grams of FD&C red dye No. 40, and 1 gram of antiseptic composition gels, the end of compartment 4 titanium dioxide. An inner glove layer of 1 mill thick SO of the glove is sealed using a silicone containing glue. polyethylene plastic (second material) is formed and cured until dry on a first hand mold. A slightly larger EXAMPLE 12 outer glove layer of 5 mil thick white neoprene rubber The gloves for Example 12 are made using a non-liq (first material) is formed and cured until dry on a second uid antiseptic composition containing 10 grams of povi hand mold, and then is evenly filled with the about 10 55 done-iodine, 45 grams of distilled sterile water, 2 grams milliliters of the antiseptic composition heated to a liq of hydroxypropylmethylcellulose, 2 grams of Carbopol uid state. The outer glove layer is then slipped over the 934, 1 gram of methylparaben, 10 grams of propylene inner glove layer on the first hand mold, and after the glycol, 0.01 grams of FD&C red dye No. 40, and 0.5 antiseptic composition gels, the end of compartment 4 grams of titanium dioxide. An inner glove layer of 1 mil of the glove is sealed using a silicone containing glue. 60 thick polyethylene plastic (second material) is formed and cured until dry on a first hand mold. A slightly EXAMPLE 9 larger outer glove layer of 4 mill thick white latex rub The gloves for Example 9 are made using a non-liquid ber (first material) is formed and cured until dry on a antiseptic composition containing 30 grams of potas second hand mold, and then is evenly filled with the sium iodide, 30 grams of elemental iodide, 90 grams of 65 about 10 milliliters of the antiseptic composition heated distilled sterile water, 60 grams of polyoxyethylene to a liquid state. The outer glove layer is then slipped glycol 1540, 60 grams of polyoxyethylene glycol 4000, over the inner glove layer on the first hand mold, and 45 grams of 1,2,6-hexanetriol, 40 grams of isopropanol, after the antiseptic composition gels, the end of com 5,357,636 63 64 partment 4 of the glove is sealed using a silicone con weight, 25 grams of polyoxyethylene glycol of 6000 taining glue. molecular weight, 10 grams of n-butanol, 30 grams of ethanol, 0.01 grams of FD&C red dye No. 40, and 0.5 EXAMPLE 13 grams of titanium dioxide. An inner glove layer of 3 mil The gloves for Example 13 are made using a non-liq thick polyethylene plastic (second material) is formed uid antiseptic composition containing 20 grams of povi and cured until dry on a first hand mold. A slightly done-iodine, 10 grams of distilled sterile water, 30 larger outer glove layer of 4 mil thick white neoprene grams of polyoxyethylene glycol of 1540 molecular rubber (first material) is formed and cured until dry on weight, 35 grams of polyoxyethylene glycol of 4000 a second hand mold, and then is evenly filled with the molecular weight, 45 grams of stearyl alcohol, 0.01 O about 10 milliliters of the antiseptic composition heated grams of FD&C red dye No. 40, and 0.5 grams of tita to a liquid state. The outer glove layer is then slipped nium dioxide. An inner glove layer of 1 mil thick poly over the inner glove layer on the first hand mold, and ethylene plastic (second material) is formed and cured after the antiseptic composition gels, the end of com until dry on a first hand mold. A slightly larger outer partment 4 of the glove is sealed using a silicone con glove layer of 4 mill thick white latex rubber (first mate 15 taining glue. rial) is formed and cured until dry on a second hand mold, and then is evenly filled with the about 10 milli EXAMPLE 1.7 liters of the antiseptic composition heated to a liquid The gloves for Example 17 are made using a non-liq state. The outer glove layer is then slipped over the uid antiseptic composition containing 25 grams of inner glove layer on the first hand mold, and after the 20 chlorhexidine gluconate, 45 grams of distilled sterile antiseptic composition gels, the end of compartment 4 water, 15 grams of polyoxyethylene glycol of 1540 of the glove is sealed using a silicone containing glue. molecular weight, 15 grams of polyoxyethylene glycol of 4000 molecular weight, 30 grams of benzyl alcohol, EXAMPLE 14 0.01 grams of FD&C red dye No. 40, and 0.5 grams of The gloves for Example 14 are made using a non-liq 25 titanium dioxide. An inner glove layer of 3 mill thick uid antiseptic composition containing 25 grams of io polyethylene plastic (second material) is formed and dine, 30 grams of polyoxyethylene glycol of 1540 mo cured until dry on a first hand mold. A slightly larger lecular weight, 30 grams of polyoxyethylene glycol of outer glove layer of 4 mil thick white latex rubber (first 4000 molecular weight, 25 grams of polyethylene glycol material) is formed and cured until dry on a second 400 monostearate, 0.01 grams of FD&C red dye No. 40, 30 hand mold, and then is evenly filled with the about 10 and 0.5 grams of titanium dioxide. An inner glove layer milliliters of the antiseptic composition heated to a liq of 1 mill thick polyethylene plastic (second material) is uid state. The outer glove layer is then slipped over the formed and cured until dry on a first hand mold. A inner glove layer on the first hand mold, and after the slightly larger outer glove layer of 4 mill thick white antiseptic composition gels, the end of compartment 4 latex rubber (first material) is formed and cured until 35 of the glove is sealed using a silicone containing glue. dry on a second hand mold, and then is evenly filled with the about 10 milliliters of the antiseptic composi EXAMPLE 1.8 tion heated to a liquid state. The outer glove layer is The gloves for Example 18 are made using a non-liq then slipped over the inner glove layer on the first hand uid antiseptic composition containing 10 grams of dry mold, and after the antiseptic composition gels, the end powdered chlorhexidine gluconate mixed with 1 gram of compartment 4 of the glove is sealed using a silicone of dry powdered gum arabic and 1 gram of dry pow containing glue. dered potassium chloride. An inner glove layer of 1 mil thick polyethylene plastic (second material) is formed EXAMPLE 1.5 and cured until dry on a first hand mold. A thin elastic The gloves for Example 15 are made using a non-liq 45 hand glove made of a fine nylon stocking mesh (compa uid antiseptic composition containing 25 grams of 20 rable in thickness to a sheer woman's leg stocking) is percent strength aqueous hydrogen peroxide, 0.1 grams placed over the innner glove on the hand mold. The of calcium citrate, 5 grams of sodium aginate, 0.5 grams pores of the nylon stocking are loaded with about 8 of methylparaben, 30 grams of glycerin, 15 grams of grams of the dry powdered antiseptic composition and distilled sterile water, 5 grams of isopropanol, 0.01 SO serve as subcompartments for the antiseptic composi grams of FD&C red dye No. 40, and 0.5 grams of tita tion. A slightly larger outer glove layer of 4 mil thick nium dioxide. An inner glove layer of 3 mil thick poly white latex rubber (first material) is formed and cured ethylene plastic (second material) is formed and cured until dry on a second hand mold, and then is slipped until dry on a first hand mold. A slightly larger outer over the powdered antiseptic composition-loaded nylon glove layer of 5 mill thick white latex rubber (first mate 55 mesh glove on the first hand mold. rial) is formed and cured until dry on a second hand mold, and then is evenly filled with the about 10 milli EXAMPLE 19 liters of the antiseptic composition heated to a liquid The gloves for Example 19 are made using a non-liq state. The outer glove layer is then slipped over the uid antiseptic composition containing 25 grams of inner glove layer on the first hand mold, and after the chlorhexidine gluconate, 15 grams of yellow wax, 17 antiseptic composition gels, the end of compartment & grams of wool fat, 40 grams of petrolatum, 22 grams of of the glove is sealed using a silicone containing glue. glycerin, 15 grams of distilled sterile water, 30 grams of ethanol, 0.01 grams of FD&C red dye No. 40, and 0.5 EXAMPLE 16 grams of zinc sulfate. An inner glove layer of 3 mill thick The gloves for Example 18 are made using a non-liq polyethylene plastic (second material) is formed and uid antiseptic composition containing 25 grams of so cured until dry on a first hand mold. A slightly larger dium hypochlorite, 45 grams of distilled sterile water, outer glove layer of 4 mill thick white latex rubber (first 25 grams of polyoxyethylene glycol of 400 molecular material) is formed and cured until dry on a second 5,357,636 65 66 hand mold, and then is evenly filled with the about 10 enforcement workers, prison workers, psychiatric hos milliliters of the antiseptic composition heated to a liq pital workers, sanitation workers, and the like workers uid state. The outer glove layer is then slipped over the whose hands do not generally need to perform delicate inner glove layer on the first hand mold, and after the maual tasks. This glove design is not optimally worn by antiseptic composition gels, the end of compartment 4 a person who would perform medical surgery, draw of the glove is sealed using a silicone containing glue. blood, or dental work where a thinner glove must be EXAMPLE 20 used. The gloves for Example 20 are made using a non-liq EXAMPLE 23 uid antiseptic composition containing 25 grams of O nonoxynol-9, 10 grams of cholesterol, 10 grams of stea The gloves for Example 23 are made using a non-liq ryl alcohol, 25 grams of white wax, and 300 grams of uid antiseptic composition containing 15 grams of so white petrolatum. An inner glove layer of 3 mill thick dium perborate NF, 15 grams of cetyl alcohol, 1 gram polyethylene plastic (second material) is formed and of white wax, 10 grams of propylene glycol, 2 grams of cured until dry on a first hand mold. A slightly larger 15 sodium laurylsulfate, 10 grams of white petrolatum and outer glove layer of 4 mill vinyl plastic (first material) is 40 grams of distilled sterile water. An inner glove layer formed and cured until dry on a second hand mold, and of 1 mill thick polyethylene plastic (second material) is then is evenly filled with the about 10 milliliters of the formed and cured until dry on a first hand mold. A antiseptic composition heated to a liquid state. The slightly larger outer glove layer of 5 mill thick white outer glove layer is then slipped over the inner glove neoprene rubber (first material) is formed and cured layer on the first hand mold, and after the antiseptic until dry on a second hand mold, and then is evenly composition gels, the end of compartment 4 of the glove filled with the about 10 milliliters of the antiseptic com is sealed using a silicone containing glue. position heated to a liquid state. The outer glove layer is EXAMPLE 21 then slipped over the inner glove layer on the first hand 25 mold, and after the antiseptic composition gels, the end The gloves for Example 21 are made using a non-liq of compartment 4 of the glove is sealed using a silicone uid antiseptic composition containing 25 grams of so containing glue. dium dichloroisocyanurate, 10 grams of cholesterol, 10 grams of stearyl alcohol, 25 grams of white wax, and EXAMPLE 24 300 grams of white petrolatum. An inner glove layer of 30 The gloves for Example 24 are made using a non-liq 3 mill thick polyethylene plastic (second material) is uid antiseptic composition containing 25 grams of potas formed and cured until dry on a first hand mold. A sium dichloroisocyanurate, 15 grams of cetyl alcohol, 1 slightly larger outer glove layer of 2 mill thick saran gram of white wax, 10 grams of propylene glycol, 2 plastic with a 3 mill thick coating of white latex rubber grams of sodium lauryl sulfate, 15 grams of mineral oil, (first material composite) is formed and cured until dry 35 and 50 grams of distilled sterile water. An inner glove on a second hand mold, and then is evenly filled with layer of 3 mill thick polyethylene plastic (second mate the about 10 milliliters of the antiseptic composition rial) is formed and cured until dry on a first hand mold. heated to a liquid state. The outer glove layer is then A slightly larger outer glove layer of 2 mill thick white slipped over the inner glove layer on the first hand polyethylene plastic (first material) is formed and cured mold, and after the antiseptic composition gels, the end until dry on a second hand mold, and then is evenly of compartment 4 of the glove is sealed using a silicone filled with the about 10 milliliters of the antiseptic com containing glue. position heated to a liquid state. The outer glove layer is EXAMPLE 22 then slipped over the inner glove layer on the first hand The gloves for Example 22 are made using a non-liq- 45 mold, and after the antiseptic composition gels, the end uid antiseptic composition containing 25 grams of hexa of compartment 4 of the glove is sealed using a silicone chlorophene, 5 grams of elemental iodine, 5 grams of containing glue. creosote, 10 grams of pine oil NF, 5 grams of phenol, 5 EXAMPLE 25 grams of potassium hypochlorite, 0.25 grams of me thyparaben, 10 grams of sodium lauryl sulfate, 80 grams 50 The gloves for Example 25 are made using a non-liq of propylene glycol, 200 grams of stearyl alcohol, 250 uid antiseptic composition containing 5 grams of baci grams of white petrolatum and 300 grams of distilled tracin, 5 grams of norfloxacin, and 2 grams of polymixin sterile water and 0.5 grams of peppermint oil. An inner B sulfate, 10 grams of calcium carbonate, 10 grams of glove layer of about 30 mils thick polyethylene plastic potassium bicarbonate, 15 grams of cetyl alcohol, 1 (second material) is formed and cured until dry on a first 55 gram of white wax, 30 grams of white petrolatum, 5 hand mold. A slightly larger outer glove layer of 40 mils grams of propylene glycol, 1 gram of menthol, I gram thick white neoprene rubber (first material) is formed of sodium laurylsulfate, and 55 grams of distilled sterile and cured until dry on a second hand mold, and then is water. An inner glove layer of 2 mil thick polyethylene evenly filled with the about 25 milliliters of the antisep plastic (second material) is formed and cured until dry tic composition in a hot liquified state. The outer glove on a first hand mold. A slightly larger outer glove layer layer is then slipped over the inner glove layer on the of 3 mill thick white polyethylene plastic (first material) first hand mold and the glove is allowed to cool so that is formed and cured until dry on a second hand mold, the composition gels. The end of compartment 4 of the and then is evenly filled with the about 10 milliliters of glove is sealed using a silicone containing glue. The the antiseptic composition heated to a liquid state. The thicker glove layers of this embodiment of the present 65 outer glove layer is then slipped over the inner glove invention are designed to provide a strong physical layer on the first hand mold, and after the antiseptic barrier and still provide a glove with suitable flexiblity composition gels, the end of compartment 4 of the glove for some gloved workers: including for example law is sealed using a silicone containing glue. 5,357,636 67 68 emulsion, an outer glove layer of 1 mill thick polyethyl EXAMPLE 26 ene plastic is spray-coated with a layer of 4 mill thick The gloves for Example 26 are made using a non-liq white latex rubber (first material) and allowed to uid antiseptic composition containing 55 grams of 37 harden. Care is taken not prevent contamination of the percent by weight formaldehyde solution (Formalin 5 two compartments, and the ends of the inner and outer solution), 20 grams of potassium iodide, 5 grams of compartments of the glove are sealed using a silicone Stearyl alcohol, 5 grams of cetyl alcohol, 1 gram of containing glue. white wax, 1.5 grams of sodium laurylsulfate, 15 grams of white petrolatum and 15 grams of mineral oil. An EXAMPLE 29 inner glove layer of 3 mill thick polyethylene plastic O The gloves for Example 29 are made using a two (second material) is formed and cured until dry on a first compartment system whose partial mixture as a result of hand mold. A slightly larger outer glove layer of 3 mil a glove wall puncture can produce small amounts of thick polyethylene plastic (first material) is formed and chlorine gas vapor from a glove puncture site. The two cured until dry on a second hand mold, and then is compartments are provided in parallel with the glove evenly filled with the about 10 milliliters of the antisep 15 wall so that the glove puncturing object can cause some tic composition heated to a liquid state. The outer glove mixture formation from the two compartments to form layer is then slipped over the inner glove layer on the a potent gaseous antiseptic that can readily diffuse to first hand mold, and after the antiseptic composition the hand and a hand wound should one occur, to pro gels, the end of compartment 4 of the glove is sealed vide an antiseptic treatment. The outer glove compart using a silicone containing glue. 20 ment contains 2 grams of concentrated hydrochloric acid solution emulsified in 10 grams of white petrolatum EXAMPLE 27 with 1 gram of ferric chloride as a colorant. The inner The gloves for Example 27 are made using a non-liq compartment contains 0.5 grams of potassium perman uid antiseptic composition containing 2 grams of potas ganate dissolved in 10 grams of distilled sterile water sium permanganate in 75 grams of distilled sterile water, 25 that has been emulsified in 3 grams of decane dissolved 1 gram of white wax, and 55 grams of white petrolatum. in 5 grams of white petrolatum and 0.5 grams of white An inner glove layer of 3 mil thick polyethylene plastic Wax. (second material) is formed and cured until dry on a first An inner glove layer of 2 mil thick polyethylene hand mold. A slightly larger outer glove layer of 1 mil plastic (second material) is formed and cured until dry thick polyethylene plastic coated with a 4 mil thick 30 on a first hand mold. This is coated with about 8 grams white latex rubber layer (first material composite) is of the permanganate emulsion composition while it is formed and cured until dry on a second hand mold, and still warm and liquified. After this emulsion gels with then is evenly filled with the about 10 milliliters of the cooling, the emulsion is spray coated with a 0.5 mil antiseptic composition heated to a liquid state. The plastic film which is allowed to dry. This intermediate outer glove layer is then slipped over the inner glove 35 plastic film layer is then dip-coated with about 8 grams layer on the first hand mold, and after the antiseptic of the formaldehyde emulsion formulation while it is composition gels, the end of compartment 4 of the glove still warm and liquified. An outer glove layer of 4 mil is sealed using a silicone containing glue. thick white neoprene rubber (first material) is spray EXAMPLE 28 coated over the galled formaldehyde emulsion and al 40 lowed to harden. Care is taken not prevent contamina The gloves for Example 28 are made using a two tion of the two compartments, and the ends of the inner compartment system whose partial mixture as a result of and outer compartments of the glove are sealed using a a glove wall puncture can increase the release of formal silicone containing glue. dehyde gas vapor from a glove puncture site. The two compartments are provided in parallel with the glove 45 EXAMPLE 30 wall so that the glove puncturing object can cause some The gloves for Example 30 are made using a non-liq mixture formation from the two compartments to form uid antiseptic composition containing 25 grams of 20 a potent gaseous antiseptic that can readily diffuse to percent hydrogen peroxide solution, 48 grams of poly the hand and a hand wound should one occur, to pro oxyethylene glycol 400 molecular weight, 48 grams of vide an antiseptic treatment. The composition for the 50 polyoxyethylene glycol 4000 molecular weight, and 10 outer glove compartment contains 5 grams of 37 per grams of stearyl alcohol. An inner glove layer of a 3 mil cent formaldehyde solution emulsified in 10 grams of thick polyethylene plastic (second material) is formed white petrolatum with 0.01 grams of red iron oxide as a and cured until dry on a first hand mold. A slightly colorant. The composition for the inner compartment larger outer glove layer of 4 mill thick white latex rub contains 0.5 grams of potassium permanganate dis 55 ber (first material) is formed and cured until dry on a solved in 10 grams of distilled sterile water that has been second hand mold, and then is evenly filled with the emulsified in 3 grams of decane dissolved in 5 grams of about 10 milliliters of the antiseptic composition heated white petrolatum and 0.5 grams of white wax. to a liquid state. The outer glove layer is then slipped An inner glove layer of 2 mil thick polyethylene over the inner glove layer on the first hand mold, and plastic (second material) is formed and cured until dry 60 after the antiseptic composition gels, the end of com on a first hand mold. This is coated with about 8 grams partment 4 of the glove is sealed using a silicone con of the permanganate emulsion composition while it is taining glue. still warm and liquified. After this emulsion gels with cooling, the emulsion is spray coated with a 1.5 mil EXAMPLE 31 plastic film which is allowed to dry. This intermediate 65 The gloves for Example 31 are made using a non-liq plastic film layer is then dip-coated with about 8 grams uid antiseptic composition containing 25 grams of 20 of the formaldehyde emulsion formulation while it is percent hydrogen peroxide solution, 48 grams of poly still warm and liquified. Over the gelled formaldehyde oxyethylene glycol 400 molecular weight, 48 grams of 5,357,636 69 70 polyoxyethylene glycol 1540 molecular weight, and 10 over the inner glove layer on the first hand mold, and grams of stearyl alcohol. An inner glove layer of 0.3 mil after the antiseptic composition gels, the end of com thick polyethylene plastic (second material) is formed partment 4 of the glove is sealed using a silicone con and cured until dry on a first hand mold. A slightly taining glue. larger outer glove layer of 5 mill thick white neoprene rubber (first material) is formed and cured until dry on EXAMPLE 35 a second hand mold, and then is evenly filled with the The gloves for Example 35 are made using a non-liq about 6 milliliters of the antiseptic composition heated uid antiseptic composition containing 8 grams of nonox to a liquid state. The latex rubber whitener (colorant) is ynol-9, 5 grams of octoxynol, 2 grams of sodium tetra zinc oxide. The outer glove layer is then slipped over 10 decyl sulfate, 24 grams of distilled sterile water, 4 grams the inner glove layer on the first hand mold, and after of sorbitan monopalmitate, 40 grams of polyoxyethyl the antiseptic composition gels, the end of compartment ene glycol 400 molecular weight, 40 grams of polyoxy 4 of the glove is sealed using a silicone glue. ethylene glycol 4000 and 10 grams of glycerin. An inner EXAMPLE 32 glove layer of 1 mill thick polyethylene plastic (second 5 material) is formed and cured until dry on a first hand The gloves for Example 32 are made using a non-liq mold. A slightly larger outer glove layer of 5 mil thick uid antiseptic composition containing 10 grams of so white latex rubber (first material) is formed and cured dium hypochlorite, 15 grams of polyoxyethylene glycol until dry on a second hand mold, and then is evenly 4000 molecular weight, 10 grams of cetyl alcohol, 10 filled with the about 10 milliliters of the antiseptic com grams of stearyl alcohol, 17 grams of glycerin, 0.7 position heated to a liquid state. The outer glove layer is grams of sodium laurylsulfate, and 50 grams of distilled then slipped over the inner glove layer on the first hand sterile water. An inner glove layer of 4 mill thick latex mold, and after the antiseptic composition gels, the end rubber (second material) is formed and cured until dry of compartment 4 of the glove is sealed using a silicone on a first hand mold. A slightly larger outer glove layer containing glue. of 4 mil thick case-hardened black latex rubber (first 25 material) is formed and cured until dry on a second EXAMPLE 36 hand mold, and then is evenly filled with the about 10 The gloves for Example 36 are made using a non-liq milliliters of the antiseptic composition heated to a liq uid antiseptic composition containing 15 grams of 50% uid state. The black colorant is powdered sterile char by weight concentrated trichloroacetic acid, 10 grams coal. The outer glove layer is then slipped over the 30 of cholesterol, 10 grams of stearyl alcohol, 25 grams of inner glove layer on the first hand mold, and after the white wax, and 300 grams of white petrolatum. An antiseptic composition gels, the end of compartment 4 inner glove layer of 3 mill thick polyethylene plastic of the glove is sealed using a silicone containing glue. (second material) is formed and cured until dry on a first EXAMPLE 33 hand mold. A slightly larger outer glove layer of 4 mil 35 thick white neoprene rubber (first material) is formed The gloves for Example 33 are made using a non-liq and cured until dry on a second hand mold, and then is uid antiseptic composition containing 10 grams of so evenly filled with the about 10 milliliters of the antisep dium hypochlorite, 40 grams of distilled sterile water, tic composition heated to a liquid state. The outer glove 32 grams of 1,2,6-hexanetriol, 47 grams of polyoxyeth layer is then slipped over the inner glove layer on the ylene glycol 400 molecular weight, and 58 grams of 40 first hand mold, and after the antiseptic composition polyoxyethylene glycol 4000. An inner glove layer of gels, the end of compartment 4 of the glove is sealed 0.6 mil thick polyethylene plastic (second material) is using a silicone containing glue. formed and cured until dry on a first hand mold. A slightly larger outer glove layer of 5 mil thick white EXAMPLE 37 latex rubber (first material) is formed and cured until 45 The gloves for Example 37 are made using a non-liq dry on a second hand mold, and then is evenly filled uid antiseptic composition containing 5 grams of euca with the about 10 milliliters of the antiseptic composi lyptus oil, 4 grams of phenyl salicylate, 3 grams of pine tion heated to a liquid state. The outer glove layer is oil NF, 5 grams of povidone-iodine, and 3 grams of then slipped over the inner glove layer on the first hand o-phenylphenol, 10 grams of cholesterol, 10 grams of mold, and after the antiseptic composition gels, the end 50 stearyl alcohol, 25 grams of white wax, and 300 grams of compartment 4 of the glove is sealed using a silicone of white petrolatum. An inner glove layer of 3 mill thick containing glue. polyethylene plastic (second material) is formed and cured until dry on a first hand mold. A slightly larger EXAMPLE 34 outer glove layer of 5 mil thick neoprene latex rubber The gloves for Example 34 are made using a non-liq 55 (first material) is formed and cured until dry on a second uid antiseptic composition containing 2 grams of ele hand mold, and then is evenly filled with the about 10 mental iodine, 3 grams of sodium iodide, 0.5 grams of milliliters of the antiseptic composition heated to a liq iodoform, 10 grams of distilled sterile water, 1 gram of uid state. The outer glove layer is then slipped over the sorbitan monopalmitate, 40 grams of polyoxyethylene inner glove layer on the first hand mold, and after the glycol 400 molecular weight, and 50 grams of polyoxy- 60 antiseptic composition gels, the end of compartment 4 ethylene glycol 4000. An inner glove layer of 2 mil of the glove is sealed using a silicone containing glue. thick polyethylene plastic (second material) is formed and cured until dry on a first hand mold. A slightly EXAMPLE 38 larger outer glove layer of 6 mill thick white latex rub The gloves for Example 38 are made using a non-liq ber (first material) is formed and cured until dry on a 65 uid antiseptic composition containing 10 grams of second hand mold, and then is evenly filled with the poloxamer 188, and 10 grams of cetylpyridinium chlo about 10 milliliters of the antiseptic composition heated ride, 50 grams of distilled sterile water, 10 grams of to a liquid state. The outer glove layer is then slipped cetyl alcohol, 5 grams of glycerin, 40 grams of polyoxy 5,357,636 71 72 ethylene glycol 400 molecular weight and 38 grams of polyoxyethylene glycol 4000 molecular weight. An EXAMPLE 41 inner glove layer of 2 mill thick polyethylene plastic The gloves for Example 41 are made using a two (second material) is formed and cured until dry on a first compartment system whose partial mixture as a result of hand mold. A slightly larger outer glove layer of 4 mil 5 a glove wall puncture can produce carbon dioxide gas thick white latex rubber (first material) is formed and bubbles in the mixture which helps to expand the mix cured until dry on a second hand mold, and then is ture which comprises the non-liquid antiseptic composi evenly filled with the about 10 milliliters of the antisep tion from the glove puncture site. The two compart tic composition heated to a liquid state. The outer glove ments are provided in parallel with the glove wall so layer is then slipped over the inner glove layer on the 10 that the glove puncturing object can cause some mix first hand mold, and after the antiseptic composition ture formation from the two compartments. The outer gels, the end of compartment 4 of the glove is sealed glove compartment contains 1 gram of elemental io using a silicone containing glue. dine, 5 grams of potassium iodide, 1 gram of peppermint EXAMPLE 39 oil, and 5 grams of 50% concentrated hydrochloric acid 15 emulsified in 10 grams of white petrolatum, 2 grams of The gloves for Example 39 are made using a non-liq red iron oxide, and 5 grams of glycerin. The inner com uid antiseptic composition containing 22 grams of meth partment contains 5 grams of sodium bicarbonate dis ylbenzethonium chloride, 50 grams of distilled sterile solved in 10 grams of distilled sterile water that has been water, 10 grams of cetyl alcohol, 5 grams of glycerin, 40 emulsified in 5 grams of white petrolatum, 0.5 grams of grams of polyoxyethylene glycol 400 molecular weight 20 white wax and 5 grams of polyoxyethylene glycol 400 and 38 grams of polyoxyethylene glycol 4000 molecular molecular weight. weight. An inner glove layer of 2 mill thick polyethyl An inner glove layer of 0.3 mill thick polyethylene ene plastic (second material) is formed and cured until plastic (second material) is formed and cured until dry dry on a first hand mold. A slightly larger outer glove on a first hand mold. This is coated with about 8 grams layer of 4 mil thick white latex rubber (first material) is 25 of the bicarbonate-containing emulsion composition formed and cured until dry on a second hand mold, and while it is still warm and liquified. After this emulsion then is evenly filled with the about 10 milliliters of the gels with cooling, the emulsion is spray coated with a antiseptic composition heated to a liquid state. The 0.5 mill plastic film which is allowed to dry. This inter outer glove layer is then slipped over the inner glove mediate plastic film layer is then dip-coated with about layer on the first hand mold, and after the antiseptic 30 8 grams of the acidic emulsion formulation while it is composition gels, the end of compartment 4 of the glove still warm and liquified. An outer glove layer of 4 mil is sealed using a silicone containing glue. thick white latex rubber (first material) is spray-coated over the gelled acidic emulsion and allowed to harden. EXAMPLE 40 Care is taken not prevent contamination of the two The gloves for Example 40 are made using a two 35 compartments, and the ends of the inner and outer com compartment system whose partial mixture as a result of partments of the glove are sealed using a silicone con a glove wall puncture can increase the release of glutar taining glue. aldehyde gas vapor from a glove puncture site. The two compartments are provided in parallel with the glove EXAMPLE 42 wall so that the glove puncturing object can cause some 40 The gloves for Example 42 are made using a two mixture formation from the two compartments to form compartment system whose partial mixture as a result of a potent gaseous antiseptic that can readily diffuse to a glove wall puncture can produce carbon dioxide gas the hand and a hand wound should one occur, to pro bubbles in the mixture which helps to expand the mix vide an antiseptic treatment. The outer glove compart ture which comprises the non-liquid antiseptic composi ment contains 5 grams of 25 percent glutaraldehyde 45 tion from the glove puncture site. The two compart solution emulsified in 10 grams of white petrolatum ments are provided in parallel with the glove wall so with 0.01 grams of red iron oxide as a colorant. The that the glove puncturing object can cause some mix inner compartment contains 0.5 grams of potassium ture formation from the two compartments. The com permanganate dissolved in 10 grams of distilled sterile position for the outer glove compartment contains 1 water that has been emulsified in 3 grams of decane 50 gram of elemental iodine, 5 grams of potassium iodide, dissolved in 5 grams of white petrolatum and 0.5 grams and 5 grams of 50% concentrated hydrochloric acid of white wax. emulsified in 10 grams of white petrolatum and 5 grams An inner glove layer of 3 mill thick polyethylene of glycerin. The composition for the inner compartment plastic (second material) is formed and cured until dry contains 5 grams of calcium carbonate dissolved in 10 on a first hand mold. This is coated with about 8 grams 55 grams of distilled sterile water that has been emulsified of the permanganate emulsion composition while it is in 5 grams of white petrolatum, 0.5 grams of white wax still warm and liquified. After this emulsion gels with and 5 grams of polyoxyethylene glycol 400 molecular cooling, the emulsion is spray coated with a 0.5 mil weight. plastic film which is allowed to dry. This intermediate An inner glove layer of 0.3 mil thick polyethylene plastic film layer is then dip-coated with about 8 grams 60 plastic (second material) is formed and cured until dry of the glutaraldehyde emulsion formulation while it is on a first hand mold. This is coated with about 8 grams still warm and liquified. An outer glove layer of 4 mil of the bicarbonate-containing emulsion composition thick white neoprene rubber (first material) is spray while it is still warm and liquified. After this emulsion coated over the gelled glutaraldehyde emulsion and gels with cooling, the emulsion is spray coated with a allowed to harden. Care is taken not prevent contamina- 65 0.5 mill plastic film which is allowed to dry. This inter tion of the two compartments, and the ends of the inner mediate plastic film layer is then dip-coated with about and outer compartments of the glove are sealed using a 8 grams of the acidic emulsion formulation while it is silicone containing glue. still warm and liquified. An outer glove layer of 4 mil 5,357,636 73 74 thick white latex rubber (first material) is spray-coated 0.5 mil plastic film which is allowed to dry. This inter over the gelled acidic emulsion and allowed to harden. mediate plastic film layer is then dip-coated with about Care is taken not prevent contamination of the two 8 grams of the acidic emulsion formulation while it is compartments, and the ends of the inner and outer com still warm and liquified. An outer glove layer of 4 mil partments of the glove are sealed using a silicone con thick white latex rubber (first material) is spray-coated taining glue. over the gelled acidic emulsion and allowed to harden. EXAMPLE 43 Care is taken not prevent contamination of the two compartments, and the ends of the inner and outer com The gloves for Example 43 are made using a two partments of the glove are sealed using a silicone con compartment system whose partial mixture as a result of O taining glue. a glove wall puncture can produce carbon dioxide gas bubbles in the mixture which helps to expand the mix EXAMPLE 45 ture which comprises the non-liquid antiseptic composi The gloves for Example 45 are made using a two tion from the glove puncture site. The two compart compartment system whose partial mixture as a result of ments are provided in parallel with the glove wall so 15 a glove wall puncture can produce carbon dioxide gas that the glove puncturing object can cause some mix bubbles in the mixture which helps to expand the mix ture formation from the two compartments. The com ture which comprises the non-liquid antiseptic composi position for the outer glove compartment contains 8 tion from the glove puncture site. The two compart grams of nonoxynol-9, and 5 grams of 50% concen ments are provided in parallel with the glove wall so trated trichloroacetic acid emulsified in 10 grams of 20 white petrolatum and 5 grams of propylene glycol. The that the glove puncturing object can cause some mix composition for the inner compartment contains 5 ture formation from the two compartments. The com grams of sodium bicarbonate dissolved in 10 grams of position for the outer glove compartment contains 10 distilled sterile water that has been emulsified in 5 grams grams of povidone-iodine, and 5 grams of 50% concen of white petrolatum, 0.5 grams of white wax and 5 25 trated hydrochloric acid emulsified in 7 grams of white grams of polyoxyethylene glycol 400 molecular weight. petrolatum and 5 grams of glycerin. The composition An inner glove layer of 0.3 mill thick polyethylene for the inner compartment contains 5 grams of sodium plastic (second material)is formed and cured until dry bicarbonate dissolved in 10 grams of distilled sterile on a first hand mold. This is coated with about 8 grams water that has been emulsified in 6 grams of white pet of the bicarbonate-containing emulsion composition 30 rolatum, and 5 grams of polyoxyethylene glycol 400 while it is still warm and liquified. After this emulsion molecular weight. gels with cooling, the emulsion is spray coated with a An inner glove layer of 0.3 mill thick polyethylene 0.5 mil plastic film which is allowed to dry. This inter plastic (second material) is formed and cured until dry mediate plastic film layer is then dip-coated with about on a first hand mold. This is coated with about 8 grams 8 grams of the acidic emulsion formulation while it is 35 of the bicarbonate-containing emulsion composition still warm and liquified. An outer glove layer of 4 mil while it is still warm and liquified. After this emulsion thick white neoprene rubber (first material) is spray gels with cooling, the emulsion is spray coated with a coated over the gelled acidic emulsion and allowed to 0.5 mill plastic film which is allowed to dry. This inter harden. Care is taken not prevent contamination of the mediate plastic film layer is then dip-coated with about two compartments, and the ends of the inner and outer 8 grams of the acidic emulsion formulation while it is compartments of the glove are sealed using a silicone still warm and liquified. An outer glove layer of 4 mil containing glue. thick white neoprene rubber (first material) is spray coated over the gelled acidic emulsion and allowed to EXAMPLE 44 harden. Care is taken not prevent contamination of the The gloves for Example 44 are made using a two 45 two compartments, and the ends of the inner and outer compartment system whose partial mixture as a result of compartments of the glove are sealed using a silicone a glove wall puncture can produce carbon dioxide gas containing glue. bubbles in the mixture which helps to expand the mix ture which comprises the non-liquid antiseptic composi EXAMPLE 46 tion from the glove puncture site. The two compart 50 The gloves for Example 46 are made using a two ments are provided in parallel with the glove wall so compartment system whose partial mixture as a result of that the glove puncturing object can cause some mix a glove wall puncture can produce carbon dioxide gas ture formation from the two compartments. The com bubbles in the mixture which helps to expand the non position for the outer glove compartment contains 10 liquid antiseptic composition mixture, partially in the grams of chlorhexidine hydrochloride, and 5 grams of 55 form of a foam and partially in the form of a viscous 50% concentrated hydrochloric acid emulsified in 7 cream base, from the glove puncture site. The two com grams of white petrolatum and 5 grams of propylene partments are provided in parallel with the glove wall glycol. The composition for the inner compartment so that the glove puncturing object can cause some contains 5 grams of sodium bicarbonate dissolved in 10 mixture formation from the two compartments. The grams of distilled sterile water that has been emulsified composition for the outer glove compartment contains in 6 grams of white petrolatum, and 5 grams of polyoxy 25 grams of methanol, and 15 grams of 50% concen ethylene glycol 400 molecular weight. trated hydrochloric acid emulsified in 12 grams of white An inner glove layer of 0.3 mill thick polyethylene petrolatum and 5 grams of glycerin. The composition plastic (second material) is formed and cured until dry for the inner compartment contains 5 grams of sodium on a first hand mold. This is coated with about 8 grams 65 bicarbonate dissolved in 10 grams of distilled sterile of the bicarbonate-containing emulsion composition water that has been emulsified in 6 grams of white pet while it is still warm and liquified. After this emulsion rolatum, and 5 grams of polyoxyethylene glycol 400 gels with cooling, the emulsion is spray coated with a molecular weight. 5,357,636 75 76 An inner glove layer of 1 mil thick polyethylene white petrolatum and 5 grams of glycerin. The compo plastic (second material) is formed and cured until dry sition for the inner compartment contains 2 grams of on a first hand mold. This is coated with about 8 grams finely dispersed catalytic manganese dioxide powder in of the bicarbonate-containing emulsion composition 20 grams of distilled sterile water that has been emulsi while it is still warm and liquified. After this emulsion 5 fied in 6 grams of white petrolatum, and 5 grams of gels with cooling, the emulsion is spray coated with a polyoxyethylene glycol 400 molecular weight. 0.5 mil plastic film which is allowed to dry. This inter An inner glove layer of 1 mill thick polyethylene mediate plastic film layer is then dip-coated with about plastic (second material) is formed and cured until dry 8 grams of the acidic emulsion formulation while it is on a first hand mold. This is coated with about 8 grams still warm and liquified. An outer glove layer of 5 mil 10 of the bicarbonate-containing emulsion composition thick white neoprene rubber (first material) is spray while it is still warm and liquified. After this emulsion coated over the gelled acidic emulsion and allowed to gels with cooling, the emulsion is spray coated with a harden. Care is taken not prevent contamination of the 0.5 mill plastic film which is allowed to dry. This inter two compartments, and the ends of the inner and outer mediate plastic film layer is then dip-coated with about compartments of the glove are sealed using a silicone 15 8 grams of the acidic emulsion formulation while it is containing glue. still warm and liquified. An outer glove layer of 5 mil thick white neoprene rubber (first material) is spray EXAMPLE 47 coated over the gelled acidic emulsion and allowed to The gloves for Example 47 are made using a two harden. Care is taken not prevent contamination of the compartment system whose partial mixture as a result of 20 two compartments, and the ends of the inner and outer a glove wall puncture can produce carbon dioxide gas compartments of the glove are sealed using a silicone bubbles in the mixture which helps to expand the non containing glue. liquid antiseptic composition mixture, partially in the form of a foam and partially in the form of a viscous EXAMPLE 49 cream base, from the glove puncture site. The two com 25 The gloves for Example 49 are made using a two partments are provided in parallel with the glove wall compartment system whose partial mixture as a result of So that the glove puncturing object can cause some a glove wall puncture can produce some carbon dioxide mixture formation from the two compartments. The gas bubbles in the mixture which helps to expand the composition for the outer glove compartment contains non-liquid antiseptic composition mixture, partially in 15 grams of 50% concentrated hydrochloric acid emul- 30 the form of a foam and partially in the form of a viscous sified in 12 grams of white petrolatum and 5 grams of cream base, from the glove puncture site. The two com glycerin. The composition for the inner compartment partments are provided in parallel with the glove wall contains 15 grams of sodium hypochlorite and 5 grams so that the glove puncturing object can cause some of Sodium bicarbonate dissolved in 10 grams of distilled mixture formation from the two compartments. The sterile water that has been emulsified in 6 grams of 35 composition for the outer glove compartment contains white petrolatum, and 5 grams of polyoxyethylene gly 15 grams of 50% concentrated hydrochloric acid emul col 400 molecular weight. sified in 12 grams of white petrolatum and 5 grams of An inner glove layer of 1 mil thick polyethylene glycerin. The composition for the inner compartment plastic (second material) is formed and cured until dry contains 15 grams of sodium iodide, 5 grams of sodium on a first hand mold. This is coated with about 8 grams bicarbonate, and 2 grams of finely dispersed catalytic of the bicarbonate-containing emulsion composition manganese dioxide powder in 25 grams of distilled ster while it is still warm and liquified. After this emulsion ile water that has been emulsified in 6 grams of white gels with cooling, the emulsion is spray coated with a petrolatum, and 5 grams of polyoxyethylene glycol 400 0.5 mill plastic film which is allowed to dry. This inter molecular weight. mediate plastic film layer is then dip-coated with about 45 An inner glove layer of 1 mill thick polyethylene 8 grams of the acidic emulsion formulation while it is plastic (second material) is formed and cured until dry still warm and liquified. Over the gelled acidic emulsion on a first hand mold. This is coated with about 8 grams an outer glove layer of 2 mill thick polyethylene plastic of the bicarbonate-containing emulsion composition is then spray-coated with a 3 mil thick layer of white while it is still warm and liquified. After this emulsion latex rubber (first material composite) and allowed to 50 gels with cooling, the emulsion is spray coated with a harden. Care is taken not prevent contamination of the 0.5 mill plastic film which is allowed to dry. This inter two compartments, and the ends of the inner and outer mediate plastic film layer is then dip-coated with about compartments of the glove are sealed using a silicone 8 grams of the acidic emulsion formulation while it is containing glue. still warm and liquified. An outer glove layer of 5 mil thick white neoprene rubber (first material) is spray EXAMPLE 48 55 coated over the gelled acidic emulsion and allowed to The gloves for Example 48 are made using a two harden. Care is taken not prevent contamination of the compartment system whose partial mixture as a result of two compartments, and the ends of the inner and outer a glove wall puncture can produce oxygen gas bubbles compartments of the glove are sealed using a silicone in the mixture which helps to expand the non-liquid 60 containing glue. antiseptic composition mixture, partially in the form of a foam and partially in the form of a viscous cream base, EXAMPLE 50 from the glove puncture site. The two compartments The gloves for Example 50 are made using a two are provided in parallel with the glove wall so that the compartment system whose partial mixture as a result of glove puncturing object can cause some mixture forma- 65 a glove wall puncture can produce oxygen gas bubbles tion from the two compartments. The composition for in the mixture which helps to expand the non-liquid the outer glove compartment contains 15 grams of 20% antiseptic composition mixture, partially in the form of hydrogen peroxide solution emulsified in 12 grams of a foam and partially in the form of a viscous cream base, 5,357,636 77 78 from the glove puncture site. The two compartments are provided in parallel with the glove wall so that the EXAMPLE 53 glove puncturing object can cause some mixture forma The gloves for Example 53 are made using a non-liq tion from the two compartments. The composition for uid antiseptic composition containing 10 grams of hy the outer glove compartment contains 15 grams of 20% drogen peroxide, 20grams of ethanol, 32 grams of 1,2,6- benzoyl peroxide solution emulsified in 12 grams of hexanetriol, 47 grams of polyoxyethylene glycol 400 white petrolatum and 5 grams of glycerin. The compo molecular weight, and 58 grams of polyoxyethylene sition for the inner compartment contains 2 grams of Glycol 4000. An inner glove layer of 2 mill thick poly finely dispersed catalytic manganese dioxide powder in ethylene plastic (second material) is formed and cured 20 grams of distilled sterile water that has been emulsi O until dry on a first hand mold. A slightly larger outer fied in 6 grams of white petrolatum, and 5 grams of glove layer of 5 milithick white latex rubber (first mate polyoxyethylene glycol 400 molecular weight. rial) is formed and cured until dry on a second hand An inner glove layer of 1 mill thick polyethylene mold, and then is evenly filled with the about 10 milli plastic (second material) is formed and cured until dry liters of the antiseptic composition heated to a liquid on a first hand mold. This is coated with about 8 grams 15 state. The outer glove layer is then slipped over the of the bicarbonate-containing emulsion composition inner glove layer on the first hand mold, and after the while it is still warm and liquified. After this emulsion antiseptic composition Gels, the end of compartment 4 gels with cooling, the emulsion is spray coated with a of the glove is sealed using a silicone containing glue. 0.5 mil plastic film which is allowed to dry. This inter 20 EXAMPLE 54 mediate plastic film layer is then dip-coated with about The gloves for Example 54 are made using a non-liq 8 grams of the acidic emulsion formulation while it is uid antiseptic composition containing 5 grams of chlor still warm and liquified. An outer glove layer of 5 mil hexidine gluconate in 20 grams ofisopropanol, 10 grams thick white neoprene rubber (first material) is spray of distilled sterile water, 20 grams of glycerine, 42 coated over the gelled acidic emulsion and allowed to 25 grams of polyoxyethylene glycol 1540 molecular harden. Care is taken not prevent contamination of the weight, and 5 grams of sodium oleate. An inner glove two compartments, and the ends of the inner and outer layer of 2 mill thick polyethylene plastic (second mate compartments of the glove are sealed using a silicone rial) is formed and cured until dry on a first hand mold. containing glue. A slightly larger outer glove layer of 2 mill thick white 30 polyethylene plastic (first material) is formed and cured EXAMPLE 51. until dry on a second hand mold, and then is evenly The gloves for Example 51 are made using a non-liq filled with the about 10 milliliters of the antiseptic com uid antiseptic composition containing 10 grams of ben position heated to a liquid state. The outer glove layer is zoyl peroxide, 40 grams of distilled sterile water, 32 then slipped over the inner glove layer on the first hand grams of 1,2,6-hexanetriol, 47 grams of polyoxyethyl 35 mold, and after the antiseptic composition gels, the end ene glycol 400 molecular weight, and 58 grams of poly of compartment 4 of the glove is sealed using a silicone oxyethylene glycol 4000. An inner glove layer of 0.6 mil containing glue. thick polyethylene plastic (second material) is formed and cured until dry on a first hand mold. A slightly EXAMPLE 55 larger outer glove layer of 5 mill thick white latex rub The gloves for Example 55 are made using a non-liq ber (first material) is formed and cured until dry on a uid antiseptic composition containing 5 grams of ele second hand mold, and then is evenly filled with the mental iodine, 5 grams of potassium iodide, 30 grams of about 10 milliliters of the antiseptic composition heated isopropanol, 2 grams of 50 percent strength glacial to a liquid state. The outer glove layer is then slipped acetic acid diluted by weight with distilled sterile water, over the inner glove layer on the first hand mold, and 45 1 gram of sodium acetate, 25 grams of polyoxyethylene after the antiseptic composition gels, the end of com glycol 1540 molecular weight, 2 grams of cetyl alcohol, partment 4 of the glove is sealed using a silicone con and 5 grams of propylene glycol. An inner glove layer taining glue. of 0.6 mill thick polyethylene plastic (second material) is formed and cured until dry on a first hand mold. A EXAMPLE 52 50 slightly larger outer glove layer of 6 mill thick white neoprene rubber (first material) is formed and cured The gloves for Example 52 are made using a non-liq until dry on a second hand mold, and then is evenly uid antiseptic composition containing 10 grams of zinc filled with the about 10 milliliters of the antiseptic com peroxide, 20 grams of 70% by volume isopropanol in position heated to a liquid state. The outer glove layer is distilled sterile water, 32 grams of 1,2,6-hexanetriol, 47 55 then slipped over the inner glove layer on the first hand grams of polyoxyethylene glycol 400 molecular weight, mold, and after the antiseptic composition gels, the end and 58 grams of polyoxyethylene glycol 4000. An inner of compartment 4 of the glove is sealed using a silicone glove layer of 2 mill thick polyethylene plastic (second containing glue. material) is formed and cured until dry on a first hand mold. A slightly larger outer glove layer of 5 mill thick EXAMPLE 56 white latex rubber (first material) is formed and cured The gloves for Example 56 are made using a non-liq until dry on a second hand mold, and then is evenly uid antiseptic composition containing 50 grams of dena filled with the about 10 milliliters of the antiseptic com tured ethanol and 15 grams of polyoxyethylene glycol position heated to a liquid state. The outer glove layer is 1540 molecular weight. An inner glove layer of 1 mil then slipped over the inner glove layer on the first hand 65 thick polyethylene plastic (second material) is formed mold, and after the antiseptic composition gels, the end and cured until dry on a first hand mold. A slightly of compartment 4 of the glove is sealed using a silicone larger outer glove layer of 4 mill thick white latex rub containing glue. ber (first material) is formed and cured until dry on a 5,357,636 79 80 second hand mold, and then is evenly filled with the (g) the glove having the additional capability to trans about 6 milliliters of the antiseptic composition heated fer some of the non-liquid antiseptic composition to a liquid state. The outer glove layer is then slipped from a section of the glove wall having a hole over the inner glove layer on the first hand mold, and resulting from the object puncturing the glove after the antiseptic composition gels, the end of com wall; the hole in the inner glove layer is relatively partment 4 of the glove is sealed using a silicone con larger than the hole in the outer glove layer and taining glue. may be used to help to direct a relatively larger While we have shown and described a number of transfer of non-liquid antiseptic composition from embodiments of our invention, it will be apparent to the glove to the hand and to the hand wound than those skilled in the art that many changes and modifica 10 from the glove to the outer surface of the glove; tions may be made without departing from our present and invention in its broader aspects. We therefore intend the (h) the glove having the capability of treating the appended claims to cover all such changes and modifi hand and the hand wound with the non-liquid anti cations as fall within the true spirit and scope of our septic composition when the object punctures the present invention. 15 glove wall, when the object contacts the hand, We claim: when the object may wound the hand, and when 1. A flexible protective glove with a liquid-impermea the object may contaminate the hand and the hand ble wall having the capability to provide a non-liquid would with the infectious pathogen; wherein the antiseptic composition treatment to a hand and to a non-liquid antiseptic composition transferred to the hand wound should the wound occur underneath the hand and the hand wound can help to protect the glove while the glove is being worn when a wall of the hand, the hand wound, and the systemic circulation glove is punctured by an object that may be contami of the individual by killing, inactivating, and other nated with an infectious pathogen, comprising: wise destroying the infectious pathogen that may (a) a glove wall with a liquid-impermeable outer layer be contaminating the hand and the hand wound. comprised of a first material having a thickness of 2. The glove according to claim 1, wherein the non about 1 mill to about 40 mils and a liquid-impermea liquid antiseptic composition is capable of being redis ble less elastic inner layer composed of a second tributed within the compartment of the glove by mas material having a thickness of about 0.3 mils to saging the glove to force the non-liquid antiseptic com about 30 mils wherein the first material and the position in the compartment to accumulate near the 30 glove wall having the hole or is capable of being auto second material form the walls of a compartment matically or manually expelled from the wall having the capable of providing a non-liquid antiseptic com hole onto the hand and into the hand wound providing position; additional non-liquid antiseptic composition to treat the (b) wherein the non-liquid antiseptic composition in skin and the hand wound resulting in additional protec the compartment comprises an antiseptic or a num 35 tion of the skin and hand would from the infectious ber of substances that can form the non-liquid anti pathogen that may be contaminating the skin and the septic composition when the object punctures the hand wound. glove wall and causes a combination of a portion of 3. A glove according to claim 1, wherein the first the substances, wherein at least a portion of the material and the second material comprise: glove wall contains the non-liquid antiseptic com 40 a structural material selected from the group consist position when the glove wall is punctured by the ing of latex rubber, cis-1,4-polyisoprene, cis object; polybutadiene, neoprene rubber, nitrile rubber, (c) the glove wall capable of providing a physical silicone rubber, case-hardened rubber, isobutylene barrier as a means of protection to the hand while isoprene 1. butyl rubber, butadieneacrylonitrile 1. the glove is being worn by an individual until a 45 nitrile rubber, styrene-butadiene rubber, ethylene portion of the glove wall is punctured by an object; propylene copolymer, ethylene-propylene diene (d) the glove wall capable of being punctured by the terpolymer, polyisobutylene, chlorosulphonated object while the glove is being worn on the hand; polyeten, ester-type urethan rubber, polychlorme (e) the glove wall having the flexibility to allow the thyloxyran epichlorhydrin rubber, epichlorhydrin hand of an individual in need of wearing the glove 50 copolymer with ethyleneoxydichlormethyloxyran to easily and adequately perform delicate, dexter copolymer cellulose acetate plastic, vinyl plastic, ous and complex work including the work per polyethylene plastic, polypropylene plastic, poly formed by a surgeon, a medical doctor, a dentist, a vinyl chloride plastic, polyvinyl acetate plastic, laboratory worker, a health care worker, a law polystyrene plastic, polymethyl methyl-acrylate enforcement worker, and a hospital worker; 55 plastic, polyacrylonitrile plastic, vinyllite plastic, (f) the glove having the capability to provide a coat saran plastic, polytetrafluoroethylene plastic, poly ing to at least a portion of the object puncturing the trifluorochloroethylene plastic, polycaprolactam glove wall; the coating comprising the non-liquid plastic, polyester plastic, urea formaldehyde plas antiseptic composition; the coating on the object tic, polyurethane plastic, isotactic polypropylene providing a means for immediately transfering 60 plastic, nylon plastic, rayon plastic, polyamide some of the non-liquid antiseptic composition onto plastic, phenolic plastic, silicone plastic, silk fiber, the hand and into the hand wound by the object cotton fiber, cellulose fiber, wool fiber, animal skin, puncturing the glove wall while the glove is being animal intestinal tissue, animal connective tissue, worn; the non-liquid antiseptic composition trans metallic fiber, mineral fiber and mixtures thereof. ferred to the hand and to the hand wound having 65 4. A glove according to claim 3, wherein the first the capability to provide an immediate non-liquid material comprises: a structural material selected from antiseptic composition treatment to the hand and the group consisting of latex rubber, cis-1,4-polyiso hand wound; prene rubber, cis-polybutadiene rubber, neoprene rub 5,357,636 81 82 ber, and nitrile rubber, silicone rubber case-hardened mium sulfate, thimerosal NF, zinc oxide, zinc acetate, rubber, isobutylene-isoprene 1. butyl rubber, zinc chloride, silver nitrate, silver sulfadiazine, hydro butadieneacrylonitrile 1. nitrile rubber, styrene-butadi gen peroxide, urea hydrogen peroxide, hydrogen perox ene rubber, ethylene-propylene copolymer, ethylene ide carbamide, benzoyl peroxide, calcium peroxide, propylene diene terpolymer, polyisobutylene, chloro magnesium peroxide, bariumperoxide, strontium perOX sulphonated polyeten, ester-type urethan rubber, poly ide, sodium peroxide, potassium perchlorite, sodium chlorimethyloxyran epichlorhydrin rubber, epichlorhy perchlorite, calcium perchlorite, magnesium perchlor drin copolymer with ethyleneoxydichlormethyloxyran ite, zinc perchlorite, zinc peroxide, zinc carbonate, zinc copolymer, and mixtures thereof; and wherein the sec hydroxide, zinc sulfate, succinyl peroxide, succinchlori ond material comprises: a structural material selected 10 mide NFIX, N-Chlorosuccinimide, potassium perman from the group consisting of cellulose acetate plastic, ganate, sodium chlorate, potassium chlorate, phenol, vinyl plastic, polyethylene plastic, polypropylene plas camphorated phenol, phenol glycerin, chloroxylenol, tic, polyvinyl chloride plastic, polyvinyl acetate plastic, 4-chloro-3,5-xylenol, sodium phenolate, domiphen bro polystyrene plastic, polymethyl methylacrylate plastic, mide, salicylic acid, bismuth-formic-iodide, bismuth polyacrylonitrile plastic, vinyllite plastic, saran plastic, 15 subgallate, bacitracin zinc, sodium lauryl sulfate, carb polytetrafluoroethylene plastic, polycaprolactam plas amide peroxide, oleic acid-iodine, pipetonyl butoxide, tic, rayon plastic, polytrifluorochloroethylene plastic, sodium peroxyborate monohydrate, ammonium ichtho nylon plastic, polyester plastic, urea formaldehyde plas sulfonate, eucalyptol, menthol, Witch Hazel, camphor, tic, polyurethane plastic, isostactic polypropylene plas tannic acid, chloroquinaldol, nalidixic acid, zinc phenol tic, polyamide plastic, phenolic plastic, silicone plastic, 20 sulfonate, zinc sulfocarbolate, hydroxynalidixic acid, silk fiber, cotton fiber, plant fiber, wool fiber, animal pipemidic acid, norfloxacin, norfloxacin hydrochloride, skin, animal intestinal tissue, animal connective tissue, 8-hydroxyquinoline sulfate, sodium phenolate, thyme metallic fiber, mineral fiber, and mixtures thereof. oil, o-cresol, m-cresol, metacresylacetate, p-cresol, cre 5. A glove according to claim 1, wherein the antisep sol NF, 4-chloro-m-cresol, 4-chloro-3,5-xylenol, saponi tic is selected from the group consisting of chlorhexi 25 fied cresol solution NF, methylphenol, ethyl phenol, dine gluconate, chlorhexidine acetate, chlorhexidine other alkyl phenols, o-phenyl phenol, other aryl phe hydrochloride, octoxynol, nonoxynol-9, methanol, eth nols, bisphenols, phenyl-mecuric chloride, phenylmecu anol, isopropanol, allyl alcohol, rubbing alcohol NF, ric borate, resorcinol, resorcinol monoactetate NF, sodium hypochlorite, potassium hypochlorite, calcium orthophenylphenol, chloroxylenol, hexylresorcinol, hypochlorite, magnesium hypochlorite, sodium dichlo 30 parachlorophenol, paratertiary-amylphenol, thymol, roisocyanurate, sodium perborate NF, sodium hydrox chlorothymol NF, butylparaban, ethylparaben, methyl ide, potassium hydroxide, magnesium hydroxide, cal paraben, propylparaben, triclosan, bithionol NF, o-ben cium hydroxide, ammonia, ammonium hydroxide, lith zyl-p-chlorophenol, hexachlorophene, poloxamer 188, a ium hydroxide, barium hydroxide, silver hydroxide, benzalkonium chloride wherein the alkyl groups at sodium tetradecyl sulfate, sulfur dioxide, pentationic 35 tached to the nitrogen represent an alkyl from CH3 to acid, colloidal sulfur, sulfur, sulfurated potash, sublimed C18H37, triclobisonium chloride, undecoylium chlo tyrothricin, hexachlorophene, hypochlorous acid, rideiodine, coal tar solution, furazolidone, nifuroxime, acetic acid, hydrochloric acid, sulfuric acid, sodium nitrofurazone NF, nitromersol NF, oxychlorosene, so acetate, aluminum acetate, acetarsone, aluminum suba dium oxychlorosene, parachlorophenol NF, camphor cetate, cadmium sulfide, selenium sulfide, bacitracin, ated parachlorophenol NF, phenylmercuric nitrate NF, coilstin, chloramphenicol, tetracycline, erythromycin, gentian violet USP, hexamethylpara-rosaniline chlo gentamycin, tobramycin, mafenide acetate, neomycin ride, rosaniline chloride, pentamethylpararosaniline sulfate, sulfisoxazole diolamine, sulfacetamide sodium, chloride, methylrosaniline chloride, tetramethyl gentamycin sulfate, amphotericin B, calomel, chiniofon, pararosaniline chloride, nonylphenoxypolyethoxye creosote, diiodohydroxyquin, eucalyptol, eucalyptus 45 thanol, methoxypolyoxyetheneglycol 550 laurate, ox oil, glycobiarsol, gramicidin, hexyl resorcinol, methy yguinoline benzoate, p-triisopropylphenoxypolye lene blue, peppermint oil, phenylethyl alcohol, phenyl thoxy-ethanol, halazone NF, dichloramine-T, benzetho salicylate, methyl salicylate, pine tar, pine oil NF, al nium chloride, econazole, cetylpyridinium chloride, pha-terpineol, borneol, fenchyl alcohol, o-methyl methylbenzethonium chloride, cetyldimethylbenzylam chavicol, polymixin B sulfate, salicylic acid, trichloro 50 montum chloride, dichlorobenzalkonium chloride, acetic acid, benzoic acid, pyrogallol NFX, pyrogallic domiphen bromide, triclocarban, clotrimazole, ci acid, sodium benzoate, boric acid, sodium borate, lactic clopirox olamine, undecylenic acid, miconazole, tolnaf acid, sodium lactate, ohiofamine, chloramine T, silver tate, acriflavine, euflavine, 3,6-diamino-10-methyla nitrate, ammoniacal silver nitrate solution, eugenol, cridium chloride, 3,6-diamino-acridine, acid acriflavine, elemental iodine, sodium iodide, potassium iodide, cal 55 5-aminoacridine hydrochloride monohydrate, mala cium iodide, ammonium iodide, silver iodide, colloidal chite green G, dodecyltrimethylammonium bromide, silver iodide in gelatin, silver lactate, ferrous iodide, tetradecyltrimethyl-ammonium bromide, dequalinium mecuric iodide red, mecuric oxide red, strontium io chloride BP, dibromopropamidine isethionite, hex dide, lithium iodide, magnesium iodide, zinc iodide, adecyltrimethylammmonium bromide, chloroazodin silver iodide, selenium iodide, thymol iodide NF X, NF X, N-chloro-p-toluenesulfonamidosodium, 4-(di dithymol diiodide, povidone-iodine, iodoform, iodol, chloroamino)sulfonyl)-benzoic acid, methenamine, me iodopyrrol, chlorinated lime, potassium bromide, so thenamine mandelate, methenamine hippurate, octox dium bromide, merbromin NF, sodium fluoride, potas ynol 9, phenazopyridine hydrochloride, 9-aminoacri sium fluoride, phenyl mercuric acetate, potassium dine hydrochloride, bismuth tribromophenate, p-tert mecuric iodide, proflavine hemisulfate, 3,6-diaminoacri 65 butylphenol, cetylidimethylethylammonium bromide, dine bisulfate, formaldehyde, glutaraldehyde, paraform chlorothymol, cloflucaban, clorophene, cloroxine, 8 aldehyde, butyl hydroxybenzoate, mercurous chloride, hydroxyquinoline, merbromin, mercuric oxide yellow, iodochlorhydroxyquin, zinc nitrate, zinc sulfate, cad ammoniated mercury, p-tert-pentylphenol, phenylmer 5,357,636 83 84 curic acetate, phenylmercuric nitrate, propylene oxide, thylammoniol-1-propanesulfonate, 3-(3-cholamido zinc pyrithione, triclocarban, zinc bacitracin, chlortet propyl)dimethylammonio)-2-hydroxypropane-1-sulfon racycline hydrochloride, calcium chlortetracycline, ate, octanoyl-N-methylglucamide, nonanoyl-N-methyl Oxytetracycline hydrochloride, beta-propiolactone, glucamide, decanoyl-N-methylglucamide, nonyl-N- acyclovir, acyclovir sodium, amantadine hydrochlo methylglucamide, lecithin, lysolecithin, nonaethylene ride, cytarabine, idoxuridine, interferon, gamma inter glycol monododecyl ether, nonaethylene glycol octyl feron, ribaviron, rifampin, suramin, trifluridine, vidara phenol ether, nonaethylene glycol octylcyclohexyl bine, zidovudine, methisazone, tumor necrosis factor, ether, heptaethylene glycol octylphenyl ether, hepta ampligen, ansamycin, (E)-5-(2-bromovinyl-2'-deoxyuri ethylene glycol octylcyclohexyl ether, polyoxyethyl dine, butylated hydroxytoluene, castamospermine, dex 10 ene (10) monolauryl ether, polyoxyethylene (8) isotride tran sulfate, dideoxycytidine, dideoxyadenosine, di cyl ether, polyoxyethylene (10) isotridecyl ether, poly deoxylnosine, Peptide-T, dihydromethylpyridinylcar oxyethylene (15) isotridecyl ether, polyoxyethylene (9) bonyloxyazidodideoxythymidine, ganciclovir, 2'- lauryl ether, polyoxyethylene (23) lauryl ether, octa fluoro-2'-deoxy-5-iodo-ara C, phosphonoformate, ethylene glycol monododecyl ether, nonaethylene gly rimantadine hydrochloride and mixtures thereof. 15 col monododecyl ether, polyethylene polypropylene 6. A glove according to claim 1, wherein the non-liq glycol, sorbitan monopalmitate, sorbitan monooleate, uid antiseptic composition contains a liquid component sorbitan monostearate, polyoxyethylene sorbitan mono selected from the group consisting of water, methanol, laurate, polyoxyethylene sorbitan monooleate, polyox ethanol, isopropanol, propanol, allyl alcohol, butanol, yethylene-4-lauryl ether, a polyethylene glycol of about isobutanol, sec-butanol, tert-butanol, benzyl alcohol, 20 150 to about 600 molecular weight, polyoxyethylene 2-methoxyethanol, 2-ethoxyethanol, 2-octyl dodecanol, glycol 400 molecular weight, polyoxyethylene glycol nonoxynol-9, n-octyl alchol, glycerol, propylene gly 1540 molecular weight, polyoxyethylene glycol 4000 col, a polyethylene glycol of about 150 to about 700 molecular weight, polyoxyethylene glycol 8000 molec molecular weight, urea, acetone, methyl ethyl ketone, ular weight, polyethylene glycol 400 monostearate, ethyl ketone, methyl isopropyl ketone, 2-pentanone, 25 polyoxyethylene-4-sorbitan monolaurate, polyoxyethy ethyl acetate, 2-methoxyethyl acetate, ethyl propionate, lene-20-sorbitan monooleate, polyoxyethylene-20-sorbi ethyl butyrate, ethyl valerate, methyl acetate, propyl tan monopalmitate, polyoxyethylene-20-sorbitan mono acetate, isopropyl acetate, 2-ethoxyethyl acetate, buryl laurate, polyoxyethylene-40-stearate, dimethicone, acetate, sec-butyl acetate, tert-butyl acetate, amyl ace simethicone, dimethylpolysiloxane, sorbitan trioleate, tate, pentyl acetate, isopentyl acetate, benzyl acetate, 30 sorbitan tristreate, propylene glycol monostearate, sor mineral oil, silicone oil, hexamethyl disiloxane, glycerol bitan sesquioleate, diphenylmethylsilicone, lauryldime trioctanoate, decyl oleate, cetearyl isononanoate, di thylbenzylammonium chloride, a perfluoropolyme methicone, perfluropolymethyisopropyl ether of about thylisopropyl ether of about 1500 to about 6600 molecu 1500 to about 8800 molecular weight, olive oil, cotton lar weight, acacia, type A gelatin, type B Gelatin, egg seed oil, corn oil, soybean oil, wheat germ oil, linseed 35 yolk phospholipids, soybean phospholipids, cholesterol, oil, pine oil, almond oil, macadamia oil, coconut oil, colloidal aluminum silicate, colloidal magnesium hy jojoba oil, peanut oil, persia oil, castor oil, cod liver oil, droxide, and mixtures thereof. shark liver oil, mink oil, squalene and mixtures thereof. 8. A glove according to claim 1, wherein the non-liq 7. A glove according to claim 1, wherein the non-liq uid antiseptic composition contains an algesic agent to uid antiseptic composition contains a surface-active increase the pain sensation perceived from the hand, to agent to facilitate the coating of the object with the alert the individual when the hand has been wounded, non-liquid antiseptic composition, the surface active the algesic agent selected from the group consisting of agent selected from the group consisting of dodecyl formic acid, acetic acid, hydrochloric acid, phosphoric dimethylamine oxide, laurylidimethylamine oxide, stea acid, sodium hydrogen phosphate, sodium phosphate, ric acid, dibutyl adipate, octyl stearate, sodium ceteary 45 potassium hydrogen phosphate, potassium phosphate, Stearate, isopropyl myristrate, palmitic acid, stearyl citric acid, sodium hydrogen citrate, sodium citrate, alcohol, cetyl alcohol, colloidal magnesium aluminum Sulfuric acid, sodium hydrogen sulfate, sodium sulfate, silicate, caprylic triglyceride, captic triglyceride, cetos sodium hypochlorite, potassium hypochlorite, brady tearyl alcohol, decyl-beta-D-glucopyranoside, nonyl kinin, substance P, bee venom, wasp venom, ant venom, beta-D-glucopyranoside, octyl-beta-D-glucopyrano 50 potassium chloride, potassium citrate, potassium sulfate, side, triethanolamine stearate, heptyl-beta-D- potassium phosphate, potassium carbonate, potassium glucopyranoside, hexyl-beta-D-glucopyranoside, dode bromide, potassium iodide, potassium fluoride, potas cyl-beta-D-maltoside, decyl-beta-D-maltoside, sodium sium hydroxide, potassium nitrate, and mixtures dodecylsulfate, sodium oleate, potassium laurate, so thereof. dium laurate, sodium lauryl sulfate, glycerol monostea 55 9. A glove according to claim 1, wherein the non-liq. rate, propylene glycol monostearate, bis(2-ethylhexyl)- uid antiseptic composition further contains a colorant as sodium sulfosuccinate, N-octylsulfobetaine, propylene a means for providing a colored visual signal to the glycol monolaurate, N-dodecylsulfatobetaine, octyl individual when and where the glove wall has been beta-D-thioglucopyranoside, heptyl-beta-D-thio punctured by the object, the colorant selected from the glucopyranoside, N-dodecyl-N,N-dimethylglycine, group consisting of a dye, an iron oxide, titanium diox cetyl alcohol, N-decylsulfatobetaine, digitonin, N-hex ide, and mixtures thereof. yldecylsulfatobetaine, N-tetradecylsulfatobetaine, dioc 10. A glove according to claim 1, wherein the non tyl sodium sulfosuccinate, N,N,bis(3-D-gluconamido liquid antiseptic composition further contains a vaso propyl)-cholamide, sodium deoxycholate, N,Nbis(3-D- constricting agent in a concentration of about 1 vaso gluconamidopropyl)-deoxycholamide, glycerol mono constricting agent part in 200,000 parts of the non-liquid stearate, sodium taurodeoxycholate, sodium cholate, antiseptic composition to about 1 vasoconstricting sodium taurocholate, sodium glycocholate, cetyltrime agent part in 2,000 parts of the liquid antiseptic compo thylammonium bromide, 3-(3-cholamidopropyl)dime sition as a means for reducing blood flow in the hand 5,357,636 85 86 wound as a means for reducing a systemic spreading of 18. A glove according to claim 1, capable of provid the infectious pathogen in the individual, the vasocon ing a non-liquid antiseptic composition, which com stricting agent selected from the group consisting of prises: a quantity of nonoxynol-9. epinephrine, norepinephrine, phenylephrine, ephedrine, 19. A method of using a flexible protective glove with metaraminol, methoxamine, and mixtures thereof. a liquid-impermeable wall containing a non-liquid anti 11. A glove according to claim 1, wherein the non septic composition or storing a number of substances liquid antiseptic composition further contains a viscosi that can form a non-liquid antiseptic composition when ty-modifying polymer as a means for increasing the the substances are combined, the wall comprising an viscosity of the non-liquid antiseptic composition, the inner layer and an outer layer wherein the inner layer viscosity-modifying polymer selected from the group 10 has a lower elasticity than the outer layer on a hand of consisting of gum arabic, xantham gum, gum acacia, an individual to protect the hand in the event that an gum tragacanth, agar, glycyrrhiza, sodium alginate, object contaminated with an infectious agent punctures bentonire, cellulose, methyl cellulose, carboxymethyl the glove, may wound the hand and may contaminate cellulose sodium, glycerol, propylene glycol, pyroxylin, the hand and the hand wound with the infectious patho polyoxyethylene glycols of about 150 to about 6000 15 gen, comprising the steps of: molecular weight, gelatin, dimethicone of about 100 to (a) using the glove initially as a liquid-impermeable about 3000 centistokes viscosity, simethicone, dimethyl physical barrier to infectious pathogens; using the polysiloxane, perfluropolymethyl-isopropyl ether of glove to permit the hand to perform a delicate, about 1500 to about 6600 molecular weight, starch, and dexterous and complex type of work that includes mixtures thereof. 20 the type of work performed by a surgeon, medical 12. A glove according to claim 1, wherein a structural doctor, a dentist, a laboratory worker, a hospital connection is made by using a third material to connect health care worker, a law enforcement worker, and the first material to the second material, the third mate a hospital worker; rial comprising: a structural material selected from the (b) using the object to puncture the wall so that the group consisting of latex rubber, cis-1,4-polyisoprene 25 wall has a hole; rubber, cis-polybutadiene rubber, neoprene rubber, ni (c) bringing the object into contact with the non-liq trile rubber, silicone rubber, case-hardened latex rubber, uid antiseptic composition or using the object to isobutylene-isoprene 1... butyl rubber, butadieneacryloni cause some combination of the substances in the trile 1. nitrile rubber, styrene-butadiene rubber, ethy wall so that some non-liquid antiseptic composition lene-propylene copolymer, ethylene-propylene diene 30 is formed when the substances are combined in terpolymer, polyisobutylene, chlorosulphonated poly some portion of the wall that has been punctured eten, ester-type urethan rubber, polychlormethyloxyran by the object; epichlorhydrin rubber, epichlorhydrin copolymer with (d) coating a portion of the object puncturing the ethyleneoxydichlormethyloxyran copolymer, cellulose glove wall with the non-liquid antiseptic composi acetate plastic, vinyl plastic, polyethylene plastic, poly 35 tion when the object punctures the glove wall; propylene plastic, polyvinyl chloride plastic, polyvinyl (e) using the object puncturing the glove as a means acetate plastic, polystyrene plastic, polymethyl methyl for transfering a portion of the coating of the non acrylate plastic, polyacrylonitrile plastic, vinyllite plas liquid antiseptic composition on the object, to the tic, saran plastic, polytetrafluoroethylene plastic, poly hand and into the hand wound when the object trifluorochloro-ethylene plastic, nylon plastic, rayon contacts the hand or the hand wound; plastic, polycaprolactam plastic, polyester plastic, urea (f) promoting a larger transfer of the non-liquid anti formaldehyde plastic, polyurethane plastic, isostactic septic composition from the glove wall to the hand polypropylene plastic, polyamide plastic, phenolic plas and hand wound, than from the glove to the outer tic, silicone plastic, silk fiber, cotton fiber, plant fiber, surface of the glove wall, when the non-liquid wool fiber, animal skin, animal intestinal tissue, animal 45 antiseptic composition is dispersed from the hole in connective tissue, metallic fiber, mineral fiber, a glue the punctured glove wall, by providing a smaller comprising at least one of the aforementioned structural hole in the outer layer than in the inner layer of the materials, and mixtures thereof. glove wall after the object has been removed from 13. A glove according to claim 12, wherein the struc the glove wall, by selecting a material composition tural connection reconfigures the compartment storing 50 for the inner glove layer that has a lower elasticity the non-liquid antiseptic composition into a plurality of than the material composition selected for the compartments capable of storing the non-liquid antisep outer glove layer; and tic composition. (g) using the non-liquid antiseptic composition trans 14. A glove according to claim 1, capable of provid ferred from and dispersed from the glove to the ing a non-liquid antiseptic composition, which com 55 hand or to the hand wound to kill, to inactivate, prises: a quantity of povidone-iodine in a non-liquid and to otherwise destroy the infectious pathogen composition. that may have been transferred to the skin and into 15. A glove according to claim 1, capable of provid the hand wound by the object. ing a non-liquid antiseptic composition, which com 20. A flexible protective glove with a liquid-imperme prises: a quantity of elemental iodine in a non-liquid 60 able wall having the capability to provide a non-liquid composition. antiseptic composition treatment to a hand and to a 16. A glove according to claim 1, capable of provid hand wound should the wound occur underneath the ing a non-liquid antiseptic composition, which com glove while the glove is being worn when a wall of the prises: a quantity of a hypochlorite salt antiseptic in a glove is punctured by an object that may be contami non-liquid composition. 65 nated with an infectious pathogen, comprising: 17. A glove according to claim 1, capable of provid (a) a glove wall with a liquid-impermeable outer layer ing a non-liquid antiseptic composition, which com comprised of a first material having a thickness of prises: a quantity of chlorhexidine gluconate. about 1 mill to about 40 mils and a liquid-impermea 5,357,636 87 88 ble inner layer composed of a second material hav glove wall; the coating comprising the non-liquid ing a thickness of about 0.3 mils to about 30 mils antiseptic composition; the coating on the object wherein the first material and the second material providing a means for immediately transfering form the walls of a compartment capable of provid some of the non-liquid antiseptic composition onto ing a non-liquid antiseptic composition; the hand and into the hand wound contacted by the (b) wherein the non-liquid antiseptic composition in object; the non-liquid antiseptic composition trans the compartment comprises an antiseptic and a ferred to the hand and to the hand wound having vasoconstrictive agent, or a number of substances the capability to provide an immediate non-liquid including a vasoconstrictive agent that can form antiseptic composition treatment to the hand and the non-liquid antiseptic composition when the 10 hand wound; object punctures the glove wall and causes a com (f) the glove having the additional capability to dis bination of a portion of the substances, wherein at perse some of the non-liquid antiseptic composition least a portion of the glove wall contains a non-liq from a section of the glove wall having a hole uid antiseptic composition when the glove wall is resulting from the object puncturing the glove punctured by an object; 15 wall; and (c) the glove wall capable of providing a physical (g) the glove having the capability to help treat the barrier as a means of protection to the hand while hand and the hand wound with the non-liquid anti the glove is being worn by an individual until a septic composition when the object punctures the portion of the glove wall is punctured by an object; glove wall, when the object may contact the hand, the glove wall capable of being punctured by the 20 when the object may wound the hand, and when object while the glove is being worn on the hand; the object may contaminate the hand and the hand (d) the glove wall having the flexibility to allow the would with the infectious pathogen; wherein the hand of an individual in need of wearing the glove non-liquid antiseptic composition transferred or to easily and adequately perform delicate, dexter dispersed to the hand and the hand wound has the ous and complex work including the work per 25 capability to help to protect the hand, the hand formed by a surgeon, a medical doctor, a dentist, a wound, and the systemic circulation of the individ laboratory worker, a health care worker, a law ual by killing, inactivating, and otherwise destroy enforcement worker, and a hospital worker; ing the infectious pathogen that may contaminate (e) the glove having the capability to provide a coat the hand and the hand wound. ing to at least a portion of the object puncturing the 30 k k k :k sk

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