Division of Research Activity Report

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Health Sciences Center at Prisma Health

Division of Research

Activity Report

Quarter 1 FY 2021 October 1, 2020 – December 31, 2020

Research Q1 Report 1

I. Executive Summary & Highlights for Q1

• 1,062 active Institutional Review Board protocols • 85 new protocols approved by the Institutional Review Board

• 34 new extramural awards totaling $9,613,826

• 38 new Clinical Trial Agreements submitted to Legal • 1497 active clinical trial research patients in Epic1 • 295 new patients enrolled in a clinical research1

1- Data reported for Prisma Health–Upstate only

Research Q1 Report 2

II. Office of Human Research Protection

IRB Active Protocols2

Q1, FY2021 Q4, FY2020 % Change Active Protocols 1,062 1,140 -6.8% New Approved Protocols 85 71 19.7%

Review Type2

Continuing New Studies Amendments Review Full Board 8 25 40 Expedited 25 102 212 Exempt 32 0 External IRB 20 0 83 Total 85 127 335 % Change from Q4 19.7 -46.6 -18.7

Funding Source / Total Active2

Federal Funding Federal Funding 345 32% 32% Industry Funding Industry Funding 256 Private / Non-Profit 43 Private / Non-Profit Internal Grant 81 Internal Grant 8% No Funding 337 4% No Funding 24%

Full Board Activity / Committee

Committee A- Committee C- Midlands4 Upstate3 Upstate3 New Studies 3 5 0 Continuing Reviews 7 15 3 Amendments 7 32 2

2- Data aggregately reported for the Upstate and Midlands 3- Effective July 1, 2019 Committee B has been deactivated. Pediatric Oncology Studies have been assigned to Committee C and all other Pediatric Studies have been assigned to committee A 4- Effective June 1, 2020 Midlands IRB Committee 2 was merged with Committee 1 and there will be one committee based in the Midlands.

Research Q1 Report 3

Active Protocols by Department- Upstate

Department5 #protocols Department5 #protocols Adult Oncology 320 Peds/ Endocrine 6 Anesthesia 5 Peds/ Gastroenterology 5 Emergency Medicine 25 Peds/ Hematology-Oncology 78 CRS 3 Peds/ Nephrology 7 Family Medicine 2 Peds/ Newborn-NICU 1 Medicine/ Vascular 9 Peds/ Neurology 2 Cardiology 21 Peds/ Neurosurgery 4 Endocrinology 3 Peds/ Pain 1 Gastroenterology 7 Peds/ Surgery 7 Infectious Diseases 11 Peds/ General 9 General Medicine 35 Pharmacy 14 Psychiatry 1 Neurology 15 Neurology/Interventional 35 Pulmonary/ Critical Care 1

Nursing 1 Radiology 4

Obstetrics and Gynecology 53 Surgery/ Vascular 18 Ortho/ General 22 Surgery/ Minimally Invasive 14 Ortho/ Trauma 3 Surgery/ Oncology 9 Ortho/ Surgery 6 Surgery/ General 21 Ortho/ Hand 1 Surgery/ Thoracic 2 Ortho/ Spine 1 Surgery/ Urology 7 Ortho/ Sports 8 Clemson University 20 Ortho/ Total Joints 4 UofSC 1 Pathology 10 UofSC/ SOM 17 Peds/ Developmental 3 UofSC/ Arnold School 8

5- Data reported for Prisma Health–Upstate only

Research Q1 Report 4

III. Office of Sponsored Programs

Overall Summary- Prisma Health

Quarterly Summary & Comparison FY20 Q1 FY21 Q1 % Change Value of Proposals $ 7,557,107 $ 11,706,157 55% Number of Proposals 25 34 36% Value of Awards $ 7,175,813 $ 9,613,826 34% Number of Awards 34 34 0%

Research Q1 Report 5

Proposal Summary

Total Proposal Activity

PRIME SUB TOTAL Direct Cost Indirect Cost Cost Share Total Requested BRADSHAW INSTITUTE 1 1 $ 1,503,406 $ 365,190 $ - $ 1,868,596 CANCER INSTITUTE 2 2 $ 36,691 $ 12,844 $ - $ 49,535 CLINICAL EXCELLENCE 1 1 $ 260,678 $ 147,022 $ - $ 407,700 CORPORATE 2 2 $ 3,765,219 $ 1,382 $ - $ 3,766,601 DENTISTRY 2 2 $ 161,702 $ 31,189 $ 74,624 $ 192,891 EMERGENCY MEDICINE 1 1 $ 1,511,884 $ 852,705 $ - $ 2,364,589 FAMILY MEDICINE 1 1 $ 9,792 $ - $ 24,346 $ 9,792 GENERAL SURGERY 2 2 4 $ 382,157 $ 138,000 $ - $ 520,157 INTERNAL MEDICINE 2 2 4 $ 698,985 $ 78,086 $ 741,425 $ 777,071 INTERNAL MEDICINE (MIDLANDS) 2 2 $ 310,685 $ 92,013 $ - $ 402,698 NEUROLOGY 1 1 $ 29,654 $ 10,367 $ - $ 40,021 OBSTETRICS & GYNECOLOGY 1 1 $ 95,454 $ 9,546 $ - $ 105,000 OBSTETRICS & GYNECOLOGY (MIDLANDS) 1 1 $ 96,379 $ 9,187 $ - $ 105,566 ORTHOPEDIC SURGERY 3 1 4 $ 254,853 $ 101,437 $ - $ 356,290 ORTHOPEDICS (MIDLANDS) 1 1 $ 4,513 $ 450 $ - $ 4,963 PEDIATRICS 3 1 4 $ 440,881 $ 211,851 $ - $ 652,732 PEDIATRICS (MIDLANDS) 1 1 $ 16,428 $ 1,971 $ - $ 18,399 ROGER C. PEACE 1 1 $ 40,637 $ 22,919 $ - $ 63,556 TOTAL 15 19 34 $ 9,619,998 $ 2,086,159 $ 840,395 $ 11,706,157

Research Q1 Report 6

Award Summary

Total Award Activity

Indirect Direct Cost Cost Share Total Awarded Cost NEW CONTINUED TOTAL Bradshaw Institute 1 1 2 $ 1,594,036 $ 399,244 $ 1,993,280 Cancer Institute 2 2 $ 33,734 $ 19,025 $ 52,759 Clinical Excellence 2 2 4 $ 1,435,607 $ 28,542 $ 856,814 $ 1,464,149 Corporate 1 1 $ 3,751,401 $ 3,751,401 Emergency Management (Midlands) 1 1 $ 66,971 $ 66,971 Emergency Medicine 3 3 $ 439,550 $ 3,637 $ 443,187 Family Medicine 1 1 $ 37,037 $ 2,963 $ 40,000 General Surgery 2 2 $ 43,059 $ 5,670 $ 48,729 Health Sciences Center 1 1 $ 75,000 $ 75,000 Internal Medicine 4 1 5 $ 782,802 $ 161,995 $ 944,797 Internal Medicine (Midlands) 1 1 $ 11,909 $ 1,191 $ 13,100 Nursing Academics 1 1 2 $ 142,806 $ 11,256 $ 154,062 Obstetrics and Gynecology 2 2 $ 74,090 $ 32,456 $ 106,546 Orthopedic Surgery 1 2 3 $ 70,860 $ 36,018 $ 106,878 Pediatrics 1 2 3 $ 322,508 $ 17,119 $ 339,627 Plastic Surgery (Midlands) 1 1 $ 13,340 $ 13,340 TOTAL 19 15 34 $ 8,894,710 $ 719,116 $ 856,814 $ 9,613,826

Research Q1 Report 7

Expenditure Summary

Upstate Midlands Total Salary Expense $1,416,211 $ 596,985 $2,013,196 Fringe Benefit Expense $ 340,202 $ 105,590 $ 445,792 Total Personnel Support $1,756,412 $ 702,575 $2,458,987 Other Direct Costs $2,902,831 $ 196,671 $3,099,503 Total Direct Costs $4,659,244 $ 899,247 $5,558,490 Indirect Costs $1,104,214 $ 4,035 $1,108,250 Total Expenditures $5,763,458 $ 903,282 $6,666,740

Research Q1 Report 8

Prisma Health- Extramural Proposals Fiscal Year 2021 – Quarter 1

The Office of Sponsored Programs reports that Prisma Health faculty and staff members submitted the following 34 proposals, totaling $11,706,157 during the first quarter of fiscal year 2021.

Proposals indicated with * are COVID-19 specific.

Bradshaw Institute for Community Child Health & Advocacy

*Dr. Kerry Sease Coronavirus Aid, Relief, and Economic Security Act via Greenville County COVID Vaccine and emerging therapy strategy Project Dates: 12/15/2020 – 12/31/2020 Total: $1,868,596; Direct: $1,503,406; Indirect: $365,190

Cancer Institute

Dr. Jeffrey Giguere Patient-Centered Outcomes Research Institute via MD Anderson Cancer Center Implementing an Intervention to Address Concerns of Older Patients with Cancer Receiving Chemotherapy and Their Caregivers Project Dates: 10/01/2021 – 09/30/2022 Total: $30,000; Direct: $21,429; Indirect: $8,571

Alicia Oostdyk Pfizer via University of South Carolina Educating and Enabling Patients in Shared Decision-making for Metastatic Breast Cancer through mHealth technology Project Dates: 01/01/2021 – 12/31/2021 Total: $19,535; Direct: $15,262; Indirect: $4,273

Clinical Excellence

*Rut Rivera Coronavirus Aid, Relief, and Economic Security Act via Greenville County Greenville County CARES Pilot Proposal Project Dates: 01/01/2021 – 12/31/2021 Total: $407,700; Direct: $260,678; Indirect: $147,022

Corporate

Kathleen Okinaga American Association of Critical-Care Nurses via Clemson University Implementing CAM-ICU delirium assessment in university and critical care settings using spaced learning techniques and standardized patient simulation technology Project Dates: 04/01/2021 – 03/31/2023 Total: $15,200; Direct: $13,818; Indirect: $1,382

Research Q1 Report 9

*Greg Rusnak Coronavirus Aid, Relief, and Economic Security Act via Greenville County Capital Needs of COVID Patients Project Dates: 12/11/2020 – 12/30/2020 Total/Direct: $3,751,401

Department of Dentistry

Dr. James Curtis National Institutes of Health via University of South Carolina PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS) – Administrative Supplement Project Dates: 01/01/2021 – 12/31/2021 Total: $120,403; Direct: $89,214; Indirect: $31,189

Dr. James Curtis The Duke Endowment via University of South Carolina Coordinating Oral and Antenatal Care for Mothers on Medicaid Project Dates: 07/01/2021 – 06/30/2024 Total/Direct: $72,488; Cost Share: $74,624

Department of Emergency Medicine

Dr. Phillip Moschella Centers for Disease Control and Prevention Comprehensive High-Impact HIV Prevention and Integrated Screening for HIV, HCV and TB for People who Inject Drugs in a Large Community-Based Organization in South Carolina Project Dates: 07/01/2021 – 06/30/2026 Total: $2,364,589; Direct: $1,511,884; Indirect: $852,705

Department of Family Medicine

Dr. Katrina Quick Society of Teachers of Family Medicine Foundation Project I3: Implementation of an Innovative Maternity Care Curriculum in a Rural Clinic Project Dates: 03/01/2021 – 02/28/2023 Total/Direct: $9,792; Cost Share: $24,346

Department of General Surgery

Dr. Alfredo Carbonell W. L. Gore & Associates, Inc. Minimally Invasive Surgery (MIS) Fellowships Project Dates: 08/01/2020 – 07/31/2021 Total/Direct: $137,474

Dr. Christopher Carsten Cook Medical Vascular Surgery Fellowship Project Dates: 01/01/2021 – 12/31/2021 Total: $5,852; Direct: $3,742; Indirect: $2,110

Research Q1 Report 10

Dr. Robert Gates National Institutes of Health via Medical University of South Carolina Evaluation of Trauma Center-Based, Technology-Enhanced Stepped Care Intervention for Adolescent Traumatic Injury Survivors Project Dates: 07/01/2021 – 06/30/2025 Total: $344,877; Direct: $220,510; Indirect: $124,367

Dr. Joel Kidd National Institutes of Health via Clemson University Novel Meta-Materials Application for Pressure-Offloading of Diabetic Foot Ulcers Project Dates: 07/01/2021 – 06/30/2024 Total: $31,954; Direct: $20,431; Indirect: $11,523

Department of Internal Medicine

Dr. John Absher National Institutes of Health via Clemson University X-ray Visualized Acidosis Sensors (X-VisAS) for Response-Guided Therapy Project Dates: 07/01/2021 – 06/30/2023 Total: $15,640; Direct: $10,000; Indirect: $5,640

Celia Beauchamp American Diabetes Association via Clemson University Health Extension for Diabetes Project Dates: 01/01/2021 – 12/31/2021 Total: $5,635; Direct: $4,900; Indirect: $735

Dr. Alain Litwin Appalachian Regional Commission Building a Recovery Ecosystem in Oconee County, SC Project Dates: 02/01/2021 – 01/31/2024 Total: $339,858; Direct: $268,147; Indirect: $71,711; Cost Share: $341,870

Dr. Prerana Roth The Duke Endowment Expanding Addiction Treatment and Recovery Connections at Prisma Health Hospitals Project Dates: 07/01/2021 – 06/30/2024 Total/Direct: $415,938; Cost Share: $399,555

Department of Internal Medicine (Midlands)

Dr. Sharon Weissman City of Columbia via University of South Carolina Housing First Program for Persons with Disabilities Project Dates: 07/01/2020 – 06/30/2021 Total/Direct: $47,490

Dr. Sharon Weissman National Institutes of Health via University of South Carolina Rapid response to incident HIV Infection to identify expanding transmission networks and inform partner services (Carolinas HIV Network) Project Dates: 07/01/2021 – 06/30/2026 Total: $355,208; Direct: $263,195; Indirect: $92,013

Research Q1 Report 11

Department of Neurology

Dr. Sen Souvik National Institutes of Health via University of South Carolina PACESETTER: Program to Avoid Cerebrovascular Events through Systemic Electronic Tracking and Tailoring of Eminent Risk Project Dates: 02/04/2020 – 12/31/2020 Total: $40,021; Direct: $29,654; Indirect: $10,367

Department of Obstetrics and Gynecology

Dr. Katheryn Isham New Morning Foundation Choose Well Initiative Project Dates: 01/01/2021 – 12/31/2021 Total: $105,000; Direct: $95,454; Indirect: $9,546

Department of Obstetrics and Gynecology (Midlands)

Dr. Patricia Seal New Morning Foundation 2021 Choose Well Initiative Project Dates: 01/01/2021 – 12/31/2021 Total: $105,566; Direct: $96,379; Indirect: $9,187

Department of Orthopedic Surgery

Dr. JD Adams National Institutes of Health via Clemson University Detecting implant infection hypoxia using Ultrasound Luminescent Chemical Imaging Project Dates: 08/01/2021 – 07/31/2023 Total: $14,698; Direct: $9,398; Indirect: $5,300

Dr. JD Adams OMeGA Medical Grants Association Orthopaedic Trauma Fellowship Support Project Dates: 08/01/2021 – 07/31/2022 Total/Direct: $75,000

Dr. JD Adams Smith+Nephew Trauma Fellowship Support Project Dates: 08/01/2021 – 07/31/2022 Total: $142,912; Direct: $91,376; Indirect: $51,536

Dr. Brayton Shirley Smith+Nephew Steadman Hawkins Clinic of the Carolinas Fellowship Program Project Dates: 08/01/2021 – 07/31/2022 Total: $123,680; Direct: $79,079; Indirect: $44,601

Research Q1 Report 12

Department of Orthopedics (Midlands)

* Dr. Calan Sowa American Medical Society for Sports Medicine Foundation COVID -19 Infection and Sports Related Injury Project Dates: 01/02/2021 – 01/01/2022 Total: $4,963; Direct: $4,513; Indirect: $450

Department of Pediatrics

*Dr. Alan Anderson National Institutes of Health via Clemson University Community Interventions to Address the Consequences of the COVID-19 Pandemic among Health Disparity and Vulnerable Adult Populations with Sickle Cell Disease in Appalachia, SC Project Dates: 07/01/2021 – 06/30/2026 Total: $565,803; Direct: $361,766; Indirect: $204,0 37

Dr. Sarah Hinton American Academy of Pediatrics, SC Chapter Telehealth ECHO Project Dates: 01/02/2021 – 12/31/2021 Total/Direct: $25,000

Dr. Nancy Powers American Academy of Pediatrics, SC Chapter Fostering Developmental-Behavioral Pediatrics Collaboration Project Dates: 01/02/2021 – 12/31/2021 Total/Direct: $2,025

Dr. Karen Ratliff-Schaub Autism Speaks Autism Learning Health Network at Prisma Health Project Dates: 04/01/2021 – 03/31/2023 Total: $59,904; Direct: $52,090, Indirect: $7,814

Department of Pediatrics (Midlands)

Dr. Stephanie Ambrose Centers for Disease Control and Prevention via University of North Carolina Community Counts: Public Health Surveillanc e for Bleeding Disorders Project Dates: 09/30/2020 – 09/29/2021 Total: $18,399; Direct: $16,428; Indirect: $1,971

Roger C. Peace Rehabilitation Hospital

Dr. Elizabeth DuBose National Institutes of Health via Clemson University Equine Assistive Therapy Inspired Pelvic-Core Stability Biomechanics for Post-Stroke Physical Rehabilitation Project Dates: 07/01/2021 – 06/30/2024 Total: $63,556; Direct: $40,637; Indirect: $22,919

Research Q1 Report 13

Prisma Health- Extramural Awards Fiscal Year 2021 – Quarter 1

The Office of Sponsored Programs reports that Prisma Health faculty and staff members received the following 34 awards, totaling $9,613,826, during the first quarter of fiscal year 2021.

Awards indicated with * are COVID-19 specific.

Bradshaw Institute for Community Child Health & Advocacy

*Dr. Kerry Sease Coronavirus Aid, Relief, and Economic Security Act via Greenville County COVID-19 Vaccine Strategy Funding to support the purchase of three mobile units for COVID-19 vaccine distribution as well as telehealth support. Project Dates: 12/02/2020 – 12/30/2020 Total: $1,868,596; Direct: $1,503,406; Indirect: $365,190

Dr. Kerry Sease Patient-Centered Outcomes Research Institute via Massachusetts General Hospital Dissemination and Implementation of Effective Childhood Obesity Treatment Innovations This year's incremental funding. Project Dates: 11/01/2020 – 10/31/2021 Total: $124,684; Direct: $90,630; Indirect: $34,054

Cancer Institute

Dr. Mark O’Rourke National Institutes of Health via Oregon Health Sciences University SWOG NCORP Research Base Continued funding to support Dr. O'Rourke as the Co-chair of the Palliative Care committee. Project Dates: 08/01/2020 – 07/31/2021 Total: $27,759; Direct: $17,749; Indirect: $10,010

Dr. Matthew Hudson National Institutes of Health via NRG Oncology Foundation, Inc. NRG Oncology NCORP Research Base Continued funding to support Dr. Hudson's time in serving as NCORP Committee Chair – CCDR. Project Dates: 08/01/2020 – 07/31/2021 Total: $25,000; Direct: $15,985; Indirect: $9,015

Research Q1 Report 14

Clinical Excellence

Heather Goss The Duke Endowment AccessHealth Mountain Lakes AccessHealth Mountain Lakes' goal is to improve health outcomes for the uninsured and the impact on the community by shifting from acute, episodic care in the ED to prevention, early intervention and chronic disease management in a medical home. Project Dates: 01/01/2021 – 12/31/2022 Total/Direct: $500,000; Cost Share: $297,014

*Rut Rivera The Duke Endowment Community Health Workers: Igniting Community-Driven Health Equity in Response to COVID-19 Prisma Health seeks to address racial, cultural, linguistic, and socio-economic factors that result in disproportionate impacts of events such as COVID-19 on Hispanic communities through deployment of Community Health Workers (CHWs) into those communities under the successful PASOs program. Project Dates: 01/01/2021 – 12/31/2022 Total/Direct: $385,000; Cost Share: $385,000

Marcus Barnes The Duke Endowment Midlands AccessHealth Community Collaborative The Midlands AccessHealth Community Collaborative focuses on helping participants navigate the healthcare system to increase access to care and improve overall health outcomes, while reducing avoidable utilization to the healthcare system in a way that also addresses the health disparities that may exist in our community. Project Dates: 01/01/2021 – 12/31/2022 Total/Direct: $500,000; Cost Share: $174,800

*Darin Thomas Coronavirus Aid, Relief, and Economic Security Act via United Housing Connections COVID-19 Quarantine Shelter Funding to support Prisma Health in providing services at the COVID-19 quarantine shelter for the homeless. Project Dates: 12/17/2020 – 12/30/2020 Total: $79,149; Direct: $50,607; Indirect: $28,542

Corporate

*Greg Rusnak Coronavirus Aid, Relief, and Economic Security Act via Greenville County Capital Needs of COVID Patients Funding to support capital equipment purchases, supplies, and education efforts related to COVID-19. Project Dates: 12/17/2020 – 12/30/2020 Total/Direct: $3,751,401

Research Q1 Report 15

Department of Emergency Medicine

Dr. Phillip Moschella Substance Abuse and Mental Health Services Administration via South Carolina Department of Alcohol and Other Drug Abuse Services Improved Access to Acute Episodic Care through Integrated Prehospital Care Response This year's incremental funding. Project Dates: 10/01/2020 – 09/30/2021 Total: $18,187; Direct: $14,550; Indirect: $3,637

Dr. Tom Blackwell Greenville Health Authority via Greenville County Emergency Management Services Improved Access to Acute Episodic Care through Integrated Prehospital Care Response This year's incremental funding. Project Dates: 10/01/2020 – 09/30/2021 Total/Direct: $212,500

Dr. Tom Blackwell Greenville County Emergency Management Services Improved Access to Acute Episodic Care through Integrated Prehospital Care Response This year's incremental funding. Project Dates: 10/01/2020 – 09/30/2021 Total/Direct: $212,500

Department of Emergency Medicine (Midlands)

HeatherLyn Gray Centers for Disease Control via South Carolina Department of Health and Environmental Control Healthcare Preparedness Program - Aeroclave Units Funding to support the purchase of two aeroclave units and training and certification of first responders and healthcare providers as Certified Healthcare Emergency Coordinators. Project Dates: 07/01/2020 – 06/30/2021 Total/Direct: $66,971

Department of Family Medicine

Dr. Blakely Amati Health Resources and Services Administration via Medical University of South Carolina Primary Care Training and Enhancement: Training Primary Care Champions The Primary Care Training and Enhancement (PCTE) Champions fellowship is a one-year program to support physicians and PAs in developing knowledge, skills, and experience in practice improvement. Project Dates: 09/01/2020 – 08/31/2021 Total: $40,000; Direct: $37,037; Indirect: $2,963

Research Q1 Report 16

Health Sciences Center

Marchie Hepner Hollingsworth Funds Medical Legal Partnership Funding to support the Medical Legal Partnership in collaboration with South Carolina Legal Services, which provides the Executive Director and access to other legal supports for program participants. Project Dates: 12/01/2020 – 11/30/2021 Total/Direct: $75,000

Department of General Surgery

Dr. Bruce Gray W. L. Gore & Associates, Inc. Five-Year Follow-up of Patients with Iliac Occlusive Disease Treated with the GORE VIABAHN VBX Balloon Expandable Endoprosthesis The prospective, multi-center, non-randomized, single-arm VIABAHN BX clinical study aims to provide 5-year safety and efficacy data assessing the 5-year long-term durability of the GORE® VIABAHN® Balloon Expandable Endoprosthesis in the treatment of patients with aortoiliac occlusive disease (AIOD) presenting with de novo or restenotic lesions. Project Dates: 11/18/2020 – 11/17/2025 Total: $15,729; Direct: $10,059; Indirect: $5,670

Dr. Alfredo Carbonell W. L. Gore & Associates, Inc. Minimally Invasive Surgery (MIS) Fellowship The Prisma Health–Upstate Division of Minimal Access and Bariatric Surgery provides a combined fellowship in advanced laparoscopy and bariatric surgery. Two fellows are trained each year in the one-year program based on patient care, continuing education, and clinical research. Project Dates: 08/01/2020 – 07/31/2021 Total/Direct: $33,000

Department of Internal Medicine

Dr. Alain Litwin Gilead Sciences, Inc. Eliminating HCV in Rural South Carolina with Smart Phone Virtual Care Coordination Deployed in NP-led Mobile Clinics Targeting PWID Under the direction of Dr. Alain Litwin through this study, 100 HCV-infected PWID will initiate HCV treatment via the NP-led mobile clinic as part of the Joseph F. Sullivan Center (JFSC) – an academic nurse managed health center. Project Dates: 09/14/2020 – 09/13/2023 Total: $750,000; Direct: $652,817; Indirect: $97,183

Dr. Alain Litwin Substance Abuse and Mental Health Services Administration via Clemson University REAL Counselor Training and Development: Reinforcing Education through Addictions- focused Learning Dr. Alain Litwin will serve on an Advisory Board as a Substance Use Disorder (SUD) Content Expert. As an advisory board member, Dr. Litwin will offer his expertise in the medical field as it relates to SUDs for modules that will be created for use in a high quality, comprehensive curriculum in the counselor education program at Clemson University.

Research Q1 Report 17

Project Dates: 09/30/2020 – 09/29/2021 Total: $5,331; Direct: $4,936; Indirect: $395

*Dr. Alain Litwin Centers for Disease Control via University of South Carolina DHEC SARS-CoV-2 Antibody Statewide Surveillance The Prisma Health–Upstate team led by Dr. Alain Litwin will provide overall scientific oversight to the COVID-19 study and will engage in regular meetings with Dr. Nolan and the surveillance study team regarding study design including survey developments, survey sampling, implementation, and dissemination as well as technical support. The Office of Digital Health will extend the use of Conversa’s chatbot to Dr. Nolan’s grant for a one-year duration. Project Dates: 08/25/2020 – 08/24/2021 Total: $55,066; Direct: $35,208; Indirect: $19,858

*Dr. Alain Litwin Centers for Disease Control via University of South Carolina DHEC SARS-CoV-2 Antibody Statewide Surveillance Additional funding to support and extended project period. Project Dates: 08/25/2020 – 12/31/2021 Total: $123,564; Direct: $79,005; Indirect: $44,559

Dr. Ohmar Win Greenville Health Authority via Furman University Addressing Health Harming Legal Barriers in the Senior Population of Greenville This year's incremental funding. Project Dates: 06/01/2020 – 05/31/2021 Total/Direct: $10,836

Department of Internal Medicine (Midlands)

Dr. Sharon Weissman Health Resources and Services Administration via University of South Carolina HRSA Special Projects of National Significance (SPNS) - Strength Through Youth Livin’ Empowered 2.0 (STYLE 2.0) This project includes innovative online intervention components that address barriers to engagement in the HIV care continuum among young Black men who have sex with men. Project Dates: 08/01/2020 – 07/31/2021 Total: $13,100; Direct: $11,909; Indirect: $1,191

Nursing Academics

Ellen Kennedy Health Resources and Services Administration via Clemson University Advanced Nurse Education Sexual Assault Nurse Examiner Program This year's incremental funding. Project Dates: 09/30/2020 – 09/29/2021 Total: $151,962; Direct: $140,706; Indirect: $11,256

Research Q1 Report 18

Suzy Hobbs Dabo’s All In Team® Foundation Greenville ALS Clinic Funding to support the purchase of a wheelchair for use in the Greenville ALS Clinic. Project Dates: 12/07/2020 – 12/06/2021 Total/Direct: $2,100

Department of Obstetrics and Gynecology

Dr. Richard P. Thomas Health Resources and Services Administration via Clemson University Rural Communities Opioid Response Program - Neonatal Abstinence Syndrome The purpose of the RCORP-NAS opportunity is to reduce the incidence and impact of Neonatal Abstinence Syndrome (NAS) in rural communities by improving systems of care, family supports, and social determinants of health. Project Dates: 09/30/2020 – 09/29/2021 Total: $103,546; Direct: $71,090; Indirect: $32,456

*Dr. Megan Schellinger Coronavirus Aid, Relief, and Economic Security Act via LiveWell Greenville Emergency Food Provider during the COVID-19 Pandemic Funding to support stocking the OB GYN clinic food pantry to support patients' needs during the COVID-19 pandemic. Project Dates: 11/12/2020 – 12/18/2020 Total/Direct: $3,000

Department of Orthopedic Surgery

Dr. Michael Kissenberth National Institutes of Health via Clemson University SC COBRE for Translational Research Improving Musculoskeletal Health (SCTRIMH) This year's annual incremental funding. Project Dates: 08/01/2020 – 07/31/2021 Total: $24,102; Direct: $15,410; Indirect: $8,692

Dr. Kyle Jeray Department of Defense via University of Maryland A pragmatic randomized trial evaluating pre-operative antiseptic skin solutions in fractured extremities (PREPARE) This year's annual incremental funding. Project Dates: 09/30/2020 – 09/29/2021 Total: $75,776; Direct: $48,450; Indirect: $27,326

Dr. JD Adams OMeGA Medical Grants Association Trauma Fellowship Additional funding to support the Trauma Fellowship for the 20-21 Academic year. Project Dates: 07/01/2020 – 06/30/2021 Total/Direct: $7,000

Research Q1 Report 19

Department of Pediatrics

Dr. Alan Anderson Health Resources and Services Administration via Atrium Health Sickle Cell Treatment Demonstration Project This year's incremental funding. Project Dates: 09/01/2020 – 08/31/2021 Total: $70,332; Direct: $63,938; Indirect: $6,394

Dr. Alan Anderson The Duke Endowment via Medical University of South Carolina South Carolina Sickle Cell Disease Access to Care Pilot Program: Building a Statewide Program through Collective Impact The South Carolina Sickle Cell Disease Network will seek to continue to improve the continuity of care for individuals with sickle cell disease and to increase access to specialized care for those individuals. Funding to support the operations at the lifespan sickle cell clinic and to expand operations to the Midlands. Project Dates: 07/01/2020 – 06/30/2021 Total/Direct: $119,000

Dr. Anne Kinsman Health Resources and Services Administration via Medical University of South Carolina Leadership Education in Neurodevelopmental and Related Disorders Training Program (SC LEND) This year's incremental funding. Project Dates: 07/01/2020 – 06/30/2021 Total: $150,295; Direct: $139,570; Indirect: $10,725

Department of Plastic Surgery (Midlands)

Dr. Mirsad Mujadzic Integra LifeSciences Corporation Lipoaspirate Shortening the Maturation of Integra and Wound Healing: Pilot Study The overall goal of this proposal is to observe, quantify, and analyze any differences in outcomes of the use of Integra versus the use of fat graft lipo-aspirate enriched by ADSC cells (SVF) along with Integra to treat difficult acute and chronic wounds. Project Dates: 11/06/2020 – 11/05/2022 Total/Direct: $13,340

Research Q1 Report 20

IV. Clinical Research Management Office

Study Metrics

Q1, FY2021 Q4, FY2020 % Change New Clinical Trial Agreements 38 32 18.8% Submitted to Legal6 New Studies Activated in Epic7 22 29 -24.1% Total Active Studies in Epic8 468 443 5.6%

Volume Activity- Prisma Health–Upstate

Total Number of Number of Number of New Active Research Encounters linked Patient Department Patients in Epic9 to Research in Enrollments in Q1 Epic10 Q1 Epic11 Q1

Anesthesiology 3 0 27 Family Medicine 0 0 0 Cardiology 149 29 88 Endocrinology 1 0 0 Gastroenterology 34 18 4 Infectious Disease 6 0 2 Neurology 27 17 10 Obstetrics & Gynecology 31 9 12 Oncology- CIOS 564 177 45 Oncology- CI 249 807 41 Oncology- ITOR 40 653 14 Orthopedics 21 3 0 Orthopedics- Hawkins 199 20 19 Pediatrics 45 32 3 Peds/ Hematology Oncology 42 461 2 Surgery 86 99 28 TOTAL 1497 2325 295 % Change from Q4 9.5 1.2 43.2

Data Sources 6- Prisma Health–Upstate and Prisma Health–Midlands PaperTracer and CTMO Start-up Tracker (Note: Includes ALL study types) 7- Prisma Health–Upstate CTMO Tracker of Epic Research Record Builds 8- Epic Report ID 1753063- Prisma Health–Upstate Research Study Search- Filter to records with “research” guarantor and “active” billing status 9 -Epic Workbench Report ID 847221, Prisma Health–Upstate Pts Enrolled in Research Study. Criteria: Research Study, Relationship "equal to": Consented-In Screening, Enrolled, Enrolled-In Active FU, Enrolled-In FU, Enrolled in Tx. Report all pts currently in 1 of those statuses (no time limit - date range is irrelevant for report as it always pulls current data). 10 -Epic Crystal Report ID 1893903, Prisma Health–Upstate Research Study Linked Encounters. Filter to include only Encounters with a status of "completed." (Set date range for target range, e.g. for last quarter.) 11 -Epic Crystal Report ID 1893903, Prisma Health–Upstate Research Study Linked Encounters. Filter to include only Encounters with a status of "completed." (Set date range for target range, e.g. for last quarter.) * All volumes EXCLUDE study type 4 "NonQCT, NonBilling" (and exclude OBGYN Choose Well study)

Research Q1 Report 21

New Studies Activated in Epic

Oncology- Cancer Institute

GRASPANC 2018-01: A Randomized, Phase 3 Study of Eryaspase in Combination with Chemotherapy versus Chemotherapy Alone as Second-Line Treatment in Patients with Pancreatic Adenocarcinoma TRYbeCA-1 – TRial of erYaspase in pancreatic CAncer Dr. Ki Chung, Oncology Funding Source: ERYTECH Pharma

URCC 19085, Wireless Transcutaneous Electrical Nerve Stimulation (TENS) for Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Phase II Clinical Trial Dr. Jeffrey Giguere, Oncology Funding Source: URCC

USO 20137: GO41854: A Phase III, Open-Label, Randomized Study of Atezolizumab and Tiragolumab Compared with Durvalumab in Patients with Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer Who Have Not Progressed After Concurrent Platinum- Based Chemoradiation (SKYSCRAPER-03) Dr. Britt Bolemon, Oncology Funding Source: USO / Roche

S1823 - A Prospective Observational Cohort Study to Assess miRNA 371 For Outcome Prediction in Patients with Newly Diagnosed Germ Cell Tumors Dr. Jeffrey Giguere, Oncology Funding Source: SWOG

USO 20157: PREEMPT CRC: PREvention Employing a Multiomics Plasma-based Test for ColoRectal Cancer Dr. Jeffrey Giguere, Oncology Funding Source: USO / Freenome, Inc.

WF 1901: Internet-delivered Management of Pain Among Cancer Treatment Survivors (IMPACTS) Dr. Jeffrey Giguere, Oncology Funding Source: Wake Forest University (WFU)

Alliance A171901 - Older Non-Small Cell Lung Cancer Patients (>/=70 Years of Age) Treated with First-Line MK-3475 (Pembrolizumab) +/- Chemotherapy (Oncologist's/Patient's Choice) Dr. Jeffrey Giguere, Oncology Funding Source: Alliance for Clinical Trials in Oncology

Replimune RPL-002-18: A Randomized, Controlled, Open-label, Phase 2 Study of Cemiplimab as a Single Agent and in Combination with RP1 in Patients with Advanced Cutaneous Squamous Cell Carcinoma Dr. Joe Stephenson, Oncology Funding Source: Replimune, Inc.

Research Q1 Report 22

E4412 - A Phase I Study with an Expansion Cohort/Randomized Phase II Study of the Combinations of Ipilimumab, Nivolumab, and Brentuximab Vedotin in Patients with Relapsed/Refractory Hodgkin Lymphoma Dr. Ki Chung, Oncology Funding Source: ECOG-ACRIN

NRG LU007 - RAndomized Phase II/III Trial Of Consolidation Radiation + Immuno-therapy for ES-SCLC: RAPTOR trial Dr. Michael Zurenko, Radiation Oncology Funding Source: NRG Oncology

ITOR

A Phase I Clinical Trial of the Combination of Famotidine (FAM) and Oral N-Acetyl Cysteine (NAC) Open Label for Outpatient Treatment of Subjects with Newly Diagnosed SARS-CoV-2 Infection Dr. John O’Connell, Radiation Oncology Funding Source: Internal funding

ODO-TE-S103: An Open-Label Hepatic Impairment Study of Tesetaxel in Patients with Advanced Solid Tumors Dr. Ki Chung, Oncology Funding Source: Odonate Therapeutics, Inc.

Department of Internal Medicine- Neurology

A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of CVN424 in Parkinson’s Disease Patients with Motor Fluctuations Dr. Fredy Revilla, Neurology Funding Source: Cerevance Beta, Inc.

Advanced Parkinson's Disease: Double-Blind, Double-Dummy, Active-Controlled, Efficacy and Safety Study of ABBV-951 Versus Oral Carbidopa/Levodopa Dr. Fredy Revilla, Neurology Funding Source: AbbVie Inc.

Department of Obstetrics and Gynecology

Collection of Bio-Fluid Samples from Pregnant Women for the Research, Development and Validation of Biomarkers Associated with Pregnancy and to aid with the Development of Novel Assay and Technologies. Dr. Eric Dellinger, Maternal and Fetal Medicine Funding Source: Discovery Life Sciences, LLC

Impact of COVID-19 on Placental Gene Expression and Pathology Dr. Amy Crockett, Maternal and Fetal Medicine Funding Source: Internal funding

Research Q1 Report 23

Use of 50 mcg Vaginal Misoprostol in Patients with Class III Obesity Dr. John Van Deman, Obstetrics and Gynecology Funding Source: Internal funding

Department of Pediatrics

Autism Learning Health Network Dr. Karen Ratliff-Schaub, Developmental-Behavioral Pediatics Funding Source: Autism Speaks

Pediatrics Hematology/Oncology

PRISMA Health Comprehensive Sickle Cell Disease Program Registry Dr. Alan Anderson, Pediatric Hematology-Oncology Funding Source: Other

Department of Pediatrics- Gastroenterology

A Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AK002 in Adult and Adolescent Patients with Active Eosinophilic Esophagitis Dr. Jonathan Markowitz, Pediatric Gastroenterology Funding Source: Allakos Inc.

Department of Surgery

Protection against Emboli during caRotid artery stenting using a 3-in-1 delivery system comprised oF a pOst-dilation balloon, integrated eMbolic filter, and A Novel Carotid stEnt II Dr. Bruce Gray, Vascular Medicine Funding Source: Contego Medical, Inc.

Five-Year Follow-up of Patients with Aortoiliac Occlusive Disease Treated with the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis Dr. Bruce Gray, Vascular Medicine Funding Source: W. L. Gore & Associates, Inc.

Research Q1 Report 24

V. Scholarly Activities

Prisma Health—Upstate

Prisma Health and UofSC School of Medicine- Greenville Authors and Contributors are indicted in BOLD text.

Biomedical Sciences

Funk, C. R., Huey, E. S., May, M. M., Peng, Y., Michonova, E., Best, R., Schwartz, C. E., & Blenda, A. V. (2020). Rare missense variant p.Ala505Ser in the ZAK protein observed in a patient with split-hand/foot malformation from a non-consanguineous pedigree. Journal of International Medical Research, 48(4). 10.1177/0300060519879293

Amalean, A., Pavuluri, H., Schmidt, W. M., & Fowler, L. (2020). The effects of sleepiness, time of day, and 12-hour shifts on affective and cognitive empathy in emergency medical technicians. Sleep and Biological Rhythms. https://doi.org/10.1007/s41105-020-00280-y

Kennedy, A. B., Ryiad, C., Gunn, L., Brown, A., Dunlap, K., Knutsen, M., Dahl, A. (2020). More than their test scores: Redefining success with multiple mini-interviews. Medical Science Educator, 30(3). 10.1007/s40670-020-01013-z

Department of Emergency Medicine

Rochester, A., Lance, T., Smith, D. E., Pfennig, C., Tyson, A., & Moschella, P. (2020). Ruptured splenic artery aneurysm in the postpartum patient: A case series. Clinical Practice and Cases in Emergency Medicine 4(3). https://escholarship.org/uc/item/0nh369wh

Walker, L. E., Phelan, M. P., & Bitner, M. (2020). Ongoing and focused provider performance evaluations in emergency medicine: Current practices and modified delphi to guide future practice. American Journal of Medical Quality, 35(4). 306-314. https://doi.org/10.1177/1062860619874113

Pirrallo, R. (2020). Using heartrate and simulation to improve tennis player performance. Journal of Medicine and Science in Tennis, 25(1).

Pittman, M. (2020). Low-cost orthopedic fracture reduction model [Abstract]. WestJEM.

*Prabhu, V. G., Taaffe, K., Pirrallo, R. & Shvorin, D. (2020). Stress and burnout among attending and resident physicians in the ED: A comparative study. IISE Transactions on Healthcare Systems Engineering. http://dx.doi.org/10.1080/24725579.2020.1814456

Research Q1 Report 25

Department of Obstetrics and Gynecology

Heberlein, E., Smith, J., Willis, C., Hall, W., Covington-Kolb, S., & Crockett, A. (2020). The effects of CenteringPregnancy group prenatal care on postpartum visit attendance and contraception use. Contraception, 102(1). https://doi.org/10.1016/j.contraception.2020.02.010

Department of Medicine

Dasari, A., Morris, V. K., Allegra, C. J., Atreya, C. Benson, A. B., Boland, P. Chung, K., et. al. (2020). ctDNA applications and integration in colorectal cancer: An NCI colon and rectal- ana task forces whitepaper. Nature Reviews Clinical Oncology. https://www.nature.com/articles/s41571-020-0392-0

Dmytriw, A. A., Phan, K., Schirmer, C., Settecase, F., Heran, M. K. S., Efendizade, A., Kuhn, A. L., Puri, A. S., Menon, B. K., Dibas, M., Sivakumar, S. Mowla, A., Leung, L. Y., Malek, A. M., Voetsch, B., Sehgal, S., Wakhloo, A. K., Wu, H., Zavier, A., & Tiwari, A. (2020). Ischaemic stroke associated with COVID-19 and racial outcome disparity in North America. Journal of Neurology, Neurosurgery, and Psychiatry. 10.1136/jnnp- 2020-324653

Goldberg, A. D., Atallah, E., Rizzieri, D., Walter, R. B., Chung, Ki., Spira, A., Stock, W., Tallman, M. S., Cruz, H. G., Boni, J. Havenith, K. E., Chao, G., Feingold, J. M., Wuerthner, J. & Solh, M. (2020). Camidanlumab tesirine, an antibody-drug conjugate, in relapsed/refractory CD25-positive acute myeloid leukemia or acute lymphoblastic leukemia: A phase I study. Leukemia Research, 95. 10.1016/j.leukres.2020.106385

Hershman, D. L., Unger, J. M., Hillyer, G. C., Moseley, A., Arnold, K. B., Dakhil, S. R., Espraz, B. T., Kuan, M. C., Graham, M. L., Lackowski, D. M., Edenfield, W. J., et al. (2020). Randomized trial of text messaging to reduce early discontinuation of adjuvant aromatase inhibitor therapy in women with early-stage breast cancer: SWOG S1105. Journal of Clinical Oncology, 38(19). http://dx.doi.org/10.1200/jco.19.02699

Jain, N., Cortez-Garcia, E., & Cartwright M. S. (2020). Cross-sectional area reference values of the median nerve at the palm using ultrasound. Muscle & Nerve, 62(3). http://dx.doi.org/10.1002/mus.27001

*Oatmen, K. E., Cull, E., & Spinale, F. G. (2020). Heart failure as interstitial cancer: Emergence of a malignant fibroblast phenotype. Nature Reviews Cardiology, 17. http://dx.doi.org/10.1038/s41569-019-0286-y

Vijayakumar, D., & Jimenez-Shahed, J. (2020). Globus Pallidus Interna Stimulation- Induced Gait Disturbance and Management by Reprogramming. In S. Chitnis, P. Khemani, & M. S. Okun (Eds.) Deep Brain Stimulation: A Cased-based Approach. Oxford University Press.

Research Q1 Report 26

Department of Orthopedics

Bryan, C. A., Hyer, L. C., & Westberry, D. E. (2020). Iatrogenic Distal Radial Physeal Fracture During Insertion of Intramedullary Fixation for a Both Bone Forearm Fracture: A Case Report. JBJS case connector, 10(3), e1900595. https://doi.org/10.2106/JBJS.CC.19.00595

Carlisle, R. M., & Tokish, J. M. (2020). Multidirectional instability of the shoulder. In M. D. Miller & S. R. Thompson (Eds). Orthopaedic Sports Medicine Principles and Practice. Elsevier: Philadelphia, PA.

*Chapman, C. G., Hudspeth, J., Floyd, S. B., Carnahan, R., Thigpen, C. A., & Kissenberth, M. J. (2020). Increased opioid use following rotator cuff repair associated with prior opioid use and surgeon prescription patterns. Journal of Shoulder and Elbow Surgery, 7S. 10.1016/j.jse.2020.04.037

Colello, M. J., Pichiotino, E. R., Tanner, S. L., Porter, S. E., & Gurich, R. W. (2020). Predicting pathologic bone lesions using scout computed tomography (CT) imaging. Sarcoma. https://doi.org/10.1155/2020/5105196

Davids, J. R., Kulkarni, V. A., Bagley, A. M., Cung, N. Q., Davis, R. B., Westberry, D. E., & Carpenter, A. (2020). Patella alta in ambulatory children with cerebral palsy: Prevalence and functional significance. Journal of Pediatric Orthopedics. 10.1097/BPO.0000000000001664

Dickerson, P., Pill, S. G., Longstaffe, R., Shanley, E., Thigpen, C. A., & Kissenberth, M. J. (2020). Systematic review of reversing pseudoparalysis of the shoulder due to massive, irreparable rotator cuff tears. Journal of Shoulder and Elbow Surgery, 29(7). 10.1016/j.jse.2020.04.039

Hyer, L. C., Carpenter, A. M., Swetenburg, J. R., & Westberry, D. E. (2020). Calcaneocuboid distraction arthrodesis for children with symptomatic pes planovalgus: Does fixation improve outcomes? Journal of Pediatric Orthopedics. 10.1097/BPB.0000000000000796

Longstaffe, R. Adams, K., Thigpen, C., Pill, S., Rush, L., Alexander, R., Hall, T. M., Siffri, P., Kwapisz, A., Hawkins, R., Tokish, J. M., Kissenberth, M., & Tolan, S. (2020). Is residual tendon a predictor of outcome following arthroscopic rotator cuff repair? A preliminary outlook at short-term follow-up. Journal of Shoulder and Elbow Surgery, 29(7). https://doi.org/10.1016/j.jse.2020.01.083

Murphy, M. J. & Murphy, T. E. (2020). Does the patient have a rotator cuff tear? In P. H. Bornemann (Ed.). Ultrasound for Primary Care. Philadelphia, PA: Wolters Kluwer.

Murphy, T.E. & Jenkins, P. F. (2020). Does the patient have an ankle sprain or fracture? In P. H. Bornemann (Ed.). Ultrasound for Primary Care. Philadelphia, PA: Wolters Kluwer.

Ode, G. E., Larson, T. B., Connor, P. M., Fleischli, J. E., & D’Alessandro, D. F. (2020). Intramedullary fixation for displaced clavicle fractures in the adolescent athlete. Journal of Surgical Orthopeadic Advances, 29(2).

Research Q1 Report 27

Pill, S. G., Rush, L., Aversen, J., Shanley, E., Thigpen, C. A., Glomset, J. L., Longstaffe, R., & Kissenberth, M. J. (2020). Systematic review of the treatment of acromioclavicular joint disruption comparing number of tunnels and graft type. Journal of Shoulder and Elbow Surgery, 29(7). 10.1016/j.jse.2020.04.008

Smith, C. D., & Sridhar, M. S. (2020). Life-threatening, bleeding pseudoaneurysm of the external iliac artery in the setting of an infected total hip arthroplasty from Pasteurella multocida. Arthorplasty Today, 6(3). 10.1016/j.artd.2020.06.014

Tokish, J. M., Thigpen, C. A., Kissenberth, M. J., Tolan, S. J., Lonergan, K. T., Tokish Jr, J. M., Dickens, J., F., Hawkins, R. J., & Shanley, E. (2020). The nonoperative instability severity index score (NISIS): A simple tool to guide operative versus nonoperative treatment of the unstable shoulder. Sports Health. DOI: 10.1177/1941738120925738

Westberry, D. E., Carpenter, A. M., & Prodoehl, J. (2020). Correction of genu valgum in patients with congenital fibular deficiency. Journal of Pediatric Orthopedics. 10.1097/BPO.0000000000001543

Westberry, D. E., Davis, R. B., Binkley-Vance, R., Westberry, A., Westberry, A., & Wack, L. I. (2020). In-toeing gait in children with clubfoot and the effect of tibial rotation osteotomy. Journal of pediatric orthopedics. Part B, 29(4), 348–354. https://doi.org/10.1097/BPB.0000000000000688

Department of Pediatrics

Buchanan, A. O. (2020). Common clinical diagnoses and conditions: Sepsis and shock. Pediatric Hospital Medicine Core Competencies, 15(S1). 10.12788/jhm.3391

Buchanan, A. O., Elkhider, I. A., & Sharkey, A. M. (2020). University of South Carolina School of Medicine Greenville. In K. S. McOwen and A. L. Farmakidis (Eds.) Academic Medicine- A Snapshot of Medical Student Education in the United States and Canada: Reports from 145 Schools. Hagerstown, MD: Wolters Kluwer.

D’Alessanddro, D. M., Ryan, M. S., Paik, S., Turner, T. L., Huber, J., Potisek, N. M., Barrett Fromme, H. (2020). An annotated bibliography of key studies in medical education in 2018: Applying the current literature to pediatric educational practice and scholarship. Academic Pediatrics, 20(5). https://doi.org/10.1016/j.acap.2020.01.012

Harper, B. D., Buchanan, A. O., Cramton, R. E. M., Gourishankar, A., King, M., Molas- Torreblanca, K., Patra, K. P., Pomeroy, B., Potisek, N. M., Seelbach, E., Tomaszewski, J. L., & Barrett Fromme, H. (2020). Developing an effective inpatient learning climate. The Clinical Teacher, 17(4). https://doi.org/10.1111/tct.13121

Mittlesteadt, J., Bambach, S., Dawes, A., Wentzel, E., Debs, A., Sezgin, E., Digby, D., Huang, Y., Ganger, A., Bhatnagar, S., Ehrenberg, L., Nunley, S., Glynn, P., Lin, S., Rust, S., & Patel, A. D. (2020). Evaluation of an activity tracker to detect seizures using machine learning. Journal of Child Neurology, 35(13). https://doi.org/10.1177/0883073820937515

Research Q1 Report 28

Department of Radiology

Mayfield, J., Schammel, C., Yurko, Y., Schammel, D. P., & Devan, A. M. (2020). Peritoneal loose bodies and the differentiation of fatty abdominal and pelvic lesions. Radiology Case Reports, 15(9). https://doi.org/10.1016/j.radcr.2020.06.040

Department of Surgery

Bell, R., Lipham, J., Louie, B. E., Williams, V., Luketich, J., Hill, M., Richards, W., Dunst, C., Lister, D., McDowell-Jacobs, L., Reardon, P., Woods, K., Gould, J., Buckley, P., Kothari, S., Khaitan, L., Smith, C. D., Park, A., Smith, C., Jacobsen, G., Abbas, G., & Katz, P. (2020). Magnetic sphincter augmentation superior to proton pump inhibitors for regurgitation in an 1-year randomized trial. Clinical Gastroenterology and Hepatology, 18(8). 10.1016/j.cgh.2019.08.056

Conte, M. S., Bradbury, A. W., Kolh, P., White, J. V., Dick, F., Fitridge, R., Mills, J. L., Ricco, J., Suresh, K. R., Hassan Murad, M., Aboyans, V., Aksoy, M., Alexandrescu, V., Armstrong, D., Azuma, N., Belch, J., Bergoeing, M., Bjorck, M., Chakfé, N., Cheng, S., Dawson, J., Debus, E. S., Dueck, A., Duval, S., Eckstein, H. H., Ferraresi, R., Gambhir, R., Gargiulo, M., Geraghty, P., Goode, S., Gray, B. et al. (2020). Corrigendum to “global vascular guidelines on the management of chronic limb- threatening ischaemia.” European Journal of Vascular and Endovascular Surgery, 60(1). 10.1016/j.ejvs.2020.04.033

DeLallo, J. F., & Carsten, C. G. (2020). A rare presentation of multiple visceral artery aneurysms. The American Surgeon. https://doi.org/10.1177%2F0003134820945256

Fatula, L., Fleming, T. Jones, B., & Carsten, C. (2020). Mycotic right subclavian artery aneurysm: A rare and challenging pathology. Journal of Vascular Surgery Cases and Innovative Techniques. https://doi.org/10.1016/j.jvscit.2020.08.002

Johansen, N., Miserez, M., de Beaux, A., Montgomery, A., Macario Faylona, J., Carbonell, A., & Bisgaard, T. (2020). Surgical strategy for contralateral groin management in patients scheduled for unilateral inguinal hernia repair: An interventional web-based surveymonkey® questionnaire: Strategy for contralateral groin management during inguinal hernia repair. Scandinavian Journal of Surgery, https://doi.org/10.1177/1457496920938600

Peterman, D. E., Knoedler, B. P., Ewing, J. E., Carbonell, A. M., Cobb, W. S., & Warren J. A. (2020). Implementation of an evidence-based protocol significantly reduces opioid prescribing after ventral hernia repair. The American Surgeon. https://doi.org/10.1177/0003134820942207

O’Connor, S. C., Mallard, M., Desai, S. S., Couto, F., Gottlieb, M., Ewing, A., Cobb, W. S., Carbonell, A. M., & Warren, J. A. (2020). Robotic versus laparoscopic approach to hiatal hernia repair: Results after 7 years of robotic experience. The American Surgeon. https://doi.org/10.1177/0003134820943547

Research Q1 Report 29

Millard, J. L., Moraney, R., Childs, J. C., Ewing, J. A., Carbonell, A. M., Cobb, W. S., & Warren, J. A. (2020). Opioid use after inguinal and ventral hernia repair. The American Surgeon. 10.1177/0003134820942179

Mokin, M., Waqas, M., Fifi, J., De Leacy, R., Fiorella, D. Levy, E. I., Snyder, K., Hanel, R., Woodward, K., Chaudry, I., Rai, A. T., Frei, D. Delgado Almandoz, J. E., Kelly, M., Arthur, A. S., Baxter, B. W., English, J., Linfante, I., Fargen, K. M., Turk, A., Siddiqui, A. H., & Mocco, J. (2020). Clot perviousness is associated with first pass success of aspiration thrombectomy in the COMPASS trial. Journal of NeuroInterventional Surgery. 10.1136/neurintsurg-2020-016434

Saad, I., & Carbonell, A. M (2020). Robotic posterior component separation. In O. Y. Kudsi (Ed). Robotic Hernia Surgery A Comprehensive Illustrated Guide. Springer Nature Switzerland AG: Springer.

Schirmer, C., Kaminsky, I., Chaudry, M., Zaidat, O., Alshekhlee, A., Ramakrishan, P., & Taqi, M. (2020). A prospective, multicenter study assessing the embolization of intracranial aneurysms using wave™ extra soft coils, a part of the penumbra smart coil® system: Study protocol for SURF [Abstract]. Journal of NeuroInterventional Surgery, 12(1). http://dx.doi.org/10.1136/neurintsurg-2020-SNIS.272

Sticco, A., Gandhi, S. S., Knoedler B., Marston, G., Ewing, A., Langan III, E. M., & Carsten, C. G. (2020). Current outcomes of blunt vertebral artery injuries. Annals of Vascular Surgery. 10.1016/j.avsg.2020.07.045

Tingen, J. S., & Carsten, C. G. (2020). Operating microscope skin burn during arteriovenous fistula creation in a pediatric patient. The American Surgeon. 10.1177/0003134820940260

Tingen, J. S., McKinley, B. P., Rinkliff, J. M., Cornett, W. R., & Lucas, C. (2020). Savi scout radar localization versus wire localization for breast biopsy regarding positive margin, complication, and reoperation rates. The American Surgeon. 10.1177/0003134820939903

Inter-departmental Collaborations

*Beachler, T., Zeller, T. A., Heo, M., Lanzillotta-Rangeley, J., & Litwin, A. H. (2020). Community attitudes toward opioid use disorder and medication for opioid use disorder in rural Appalachian county. Journal of Rural Health. http://dx.doi.org/10.1111/jrh.12503

*Denotes a Prisma Health and HSC Academic Affiliate Scholarly Outcome