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Supplementary Figure S1. The SARS-CoV-2 Knowledge Graph SARS-CoV-2 Host genes (322) baits (27) 1,783 genes on 609 pathways 15 Target (4,427) 10 723 84 Phenotypes (1,285) Drugs (3,635) Supplementary Figure S2. Interactive t-sne plot inorganic cation transmembrane DIOSMIN EXTL1 SIGMAR1 HEATR3 LIPT2 CD6 SIGLEC1 CD2 TBCA STOML2 NAA80 CDH15 CDH3 MAG NEGR1 CADM3 CADM1 CD99 CDH5 ESAM positive regulation of neutrophil transport "TRANS-10 activation L 750667 CACOSPONGIONOLIDE B MIMOSINE VOLATILE ORGANICBRUCINE COMPOUNDS "1-PHENYL-6 ATP6AP1 ATRACTYLENOLIDE I HOMOCASTASTERONE ISOPENTYL ALCOHOL MEMANTINE AH 13205 DELPHINIDINPOLYETHYLENE GLYCOLMANSONONE 6000 G SARS-CoV2 orf7a SOFOSBUVIR LIAS EXT2 4-(4-(4-CHLORO-PHENYL)THIAZOL-2-YLAMINO)PHENOL TRIMETHYLARSINE OXIDE EXT1 SARS-CoV2 nsp6 8-CHLORO-2'-DEOXYGUANOSINEALGINIC ACID DIAMIDE ROPIVACAINE ALCAM SPN CD58 SARS-CoV2 nsp11SARS-CoV2 orf3b YOD1 MANGOSTIN HERBICIDESFLUNISOLIDEGW 6471 PHOSPHORYLCHOLINE DIACETYLDICHLOROFLUORESCEIN BENTONITE TRIENOMYCIN A positive regulation of leukocyte OLEOYL-ESTRONESIPONIMOD PRISTANE positive regulation of productionANETHOLE TRITHIONE bone remodeling VANOXERINEadhesion to arterial endothelial BN 50739 DONG QUAI ATP13A3 KAMEBAKAURIN of miRNAsinterleukin-1 involved receptor in gene antagonist endocrine pancreas developmentPYRIDOXAMINE ISOMENTHONEtoll-like receptor 3 signalingMECLOFENAMIC cell ACID "6-(4-FLUOROPHENYL)-2 "(2Svesicle MRS 2211silencing by miRNAactivity regulation of calcium-mediated 4-ETHYLNAPHTHALEN-1-YL-(1-PENTYLINDOL-3-YL)METHANONEpathway CYCLAMATES positive regulationCHROMIUM of DINICOCYSTEINATE MDN1 LIPT1 RUSCOGENIN LYCIUMULTRA-HIGH BARBARUM MOLECULARLUZINDOLE MARBOFLOXACIN MALEIC ACID regulation of protein signaling negative regulationnegative of lipid regulation of branching fractalkinecysteine-type production endopeptidaseKMUP 1 EXTL2 POLYSACCHARIDEWEIGHT POLYETHYLENEFENUGREEK SEED TIOTROPIUMMEAL BROMIDENALTREXONE LICARIN A phosphorylation regulationpositive of regulationnitric-oxide of STATVELIPARIB metabolic processinvolved in lung morphogenesis FLUTOLANILCALYCOPTERIN activity involvedintegrin inBENZYLIDENEACETONE apoptotic binding AZA-(6)-GINGEROL"4-DIMETHYLAMINO-3' EXTL3 ATP5MG "PLANT EXTRACTPYRUVATES negativePHENYLBUTAZONE regulation"NUCLEIC of alkaline ACIDS negativepositive regulation regulation ofrecycling viral of triglycerideendosomecellular extravasation LG 268 synthase activitycascade PLAUNOTOL ALLYL ISOTHIOCYANATE OENOTHEINPHENTOLAMINEFENAMIC B process ACID PROPOLIS positive regulation of synoviocyte phosphatase activity genome replicationmetabolic process SULGLICOTIDE "1-(BETA-NAPHTHYLMETHYL)-6POLYETHYLENECOPPER GLYCOL HISTIDINE 1000 PIPERLONGUMININE3-METHYLCATECHOLCYSTEINEproliferation PROTEINASE INHIBITORS LANTHANUMQUIN2 OXIDE CHLORMETHIAZOLEDAPOXETINE EPOXY COMPOUNDS PEANUT OIL SAXAGLIPTINMIRANSERTIB BOLINAQUINONE ANTIPARKINSONpositive regulation AGENTS of T-helper 2 death-inducingCRYPTOTANSHINONE signaling STRYCHNINE 5-HYDROXYDECANOIC ACID positive regulation of T cell GSK690693HYDROXYAPATITESPIMARIC ACID EUDRAGIT RSPO SANGUINARINECHAETOGLOBOSINScell differentiation positive regulationZMCDRIcomplex 241385 of DNA85-287 assembly PEGYLATED SOLUBLE TUMOR mediatedERIONITE immunity TEBUCONAZOLEBUTYLPHEN"4-CYANO-4-(2NVP ABE171 D-JNKI-1 COBALT-NICKEL-CHROMIUM-MOLYBDENUM FLAVONOLS biosynthetic process PFDINITROBENZENESULFONIC 03715455NECROSIS FACTORTETRACHLOROETHYLENE RECEPTOR ACID I positiveBERAPROST regulation of I-kappaB NECROSTATIN-1ALLOY glucagon secretionregulation of fat cell GW 192917-HYDROXYJOLKINOLIDE B COENZYMEDELTA-TOCOPHEROL Q10 ALUMINUM NITRATE COFFEE phosphorylationglucose ASTM metabolic F-75 IMPLANTprocessABACAVIR ALLOY IDELALISIBBENZOPYRANS PROSTAGLANDIN A2 positive regulation of differentiation BENZOYLCARBONYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTYL-FLUOROMETHYLnegative regulation of ZOTAROLIMUSprotein "TOXB PROTEIN cellular response to amyloid-beta ACETYL3-BENZYL-5-((2-NITROPHENOXY)METHYL)DIHYDROFURAN-2(3H)-ONE COENZYME A AMINOPYRINE PHTHALIC ACIDS BLEOMYCETIN programmed cell death PEGINTERFERONSPD-304positive ALFA-2Bregulation of KETONEkinase activity IMIDACLOPRIDCHLORDECONEROSEMARY OIL ETHYLMERCURY COMPOUNDS branching"PREGNA-4 involvedDIMETHYL in salivary SULFONE circadian rhythmtranscriptionZK 216348 regulatory region AUROTHIOGLUCOSE granulocyte macrophageMATRIX METALLOPROTEINASE ALLOIN NSC668394 WALLEMINONEpositive regulation of p38MAPKRO 31-8425 TGX 221 SU CHROMIC5402 KR-316125-OH-BDE-47 ACID ALUMINUM SULFATETYROSYL-VALYL-ALANYL-ASPARTIC2-DICHLOROBENZENEMICROCRYSTALLINE CELLULOSEresponseOLIVE OIL to organic cyclic 4-VINYLPYRIDINEpositivesequence-specific regulationpositiveCHAETOMUGILINGANCICLOVIR ofregulationtumor protein DNA necrosis binding ofOCTYLPHENOL ceramide D factor-mediated TRITERPENES colony-stimulatingMYCOTRIENIN I 10-NITRO-OLEICfactorINHIBITORS gland morphogenesis ACID 4-AMINOBENZHYDRAZIDE RU 43044 cascade 1-OLEOYL-2-ACETOYL-SN-GLYCEROLLAMINARAN "1-NAPHTHYLETHYL-6 negative regulationCARTHAMUS of positiveglucoseGINSENOSIDE YELLOW regulation RH2 of ACID FLUOROMETHYLSPLITOMICIN KETONE compound BUTEINPREDNISONE kinase activity signaling pathway "3-(3-CHLORO-4-METHOXYPHENYL)-1 productionplatelet activation positive regulationEMODIN-6-O-GLUCOSIDE of protein CYANIDIN JBT-30021-HYDROXY-1-NORRESISTOMYCINGW280264X proteasebiosynthetic binding process interleukin-1 receptorregulation binding of ERK1transmembrane and ERK2 transportnitric-oxide synthase FRUCTOSAMINE BIOCHANINBENZYLOXYCARBONYL-ISOLEUCYL-GLUTAMYL-THREONYL-ASPARTIC A positive regulation of DITIOCARBDOPEXAMINEOBACUNONE GLUCOSIDE GSK2141795 BUSULFAN response to ATP BACTERIAL TOXINS8-PRENYLNARINGENINtransport N-2-(4-BROMOPHENYL)3-O-GLUCOPYRANOSIDE ETHYL CARVONEETIRON positivecascade regulation of myosinbiosynthetic ONAPRISTONE process3-(4-(4-((1-(2-CHLOROPHENYL)ETHOXY)CARBONYLnegative LINALOOL regulation of branching GAMMA-TOCOPHEROL DESLORATADINEinterleukin-6ACIDESTRAGOLE receptorinterleukin-1 FLUOROMETHYL binding beta KETONEbiosynthetic GINKGO BILOBANANDROLONESR 48968EXTRACT DECANOATE CC 3052 CAFFEAMIDE CYCLOPROPAPYRROLOINDOLEASPERULOSIDICGLUCOSAMINEBROMOCRIPTINE ACID 6-PHOSPHATEresponse to gold nanoparticle 2-METHOXYCINNAMALDEHYDElight chain kinaseANTIMICROBIAL activity DIMETHYLPHENYLPIPERAZINIUM CATIONIC morphogenesisAMINO)-3-METHYL-5-ISOXAZOLYL) of a nerve ALPHA-METHYLSEROTONIN negativeIPATASERTIBACETOXYCYCLOHEXIMIDE regulation of bile acid process TEPHROSIN negativeMK-8825 regulation of gap CATALPOLpositive regulation of cell SODIUMinterleukin-6 BROMATE productionCHETOMIN"N''-CYANO-N-(6-AMINO-3negative regulation of bicellularMONOPHOSPHORYL PERIFOSINE LIPID A PEPTIDES IODIDE BENZYLSULFANYL)BU-ZHONG-YI-QI-TANGDAMASCENONESENECIONINE PROPANOIC cellular responsesecretion to organic CARNOSOL PHELLODENDRINE "BENZO(A)PYRENE 7 QUINOTRIERIXIN junction assembly ALMONDproliferation OIL in boneWP9QY marrow PEPTIDE 4-NITROBENZYLDIOSBULBIN B BROMIDE CADMIUM OXIDE tight junctionAMYRONE assembly TROLEANDOMYCINnegative ADENOSINEregulation of DIPHOSPHATE CLORICROMENapoptotic AJOENE POLYpositive DA-DT regulation of monocyte "PYRIDOXALACID negativesubstanceROSSICASIDE regulation 8-CHLOROGUANOSINE B of myelination response to calcium PHENYLHYDRAZINEion "N-(1-METHYLETHYL)-1 POTASSIUM CHLORIDE PTAQUILOSIDECYTOCHALASINregulation of single B stranded ANGELICAE SINENSISA 192621 EXTRACT SINOMENINE TRAMADOLresponse(5-FORMYLFURAN-2-YL)METHYL to stilbenoid signaling pathway GSK0660 SULFADIAZINE chemotactic protein-1AG-879 PHOSPHATE-6-AZOPHENYL-2'CYLINDROSPERMOPSIN SARGAQUINOICQUINOXALINES ACID OCTANOIC ACIDLETROZOLE INDOMETHACIN9-ANILINOACRIDINE responseectopic to organonitrogen germ cell CIBINETIDEprogrammed 3-NITROPROPIONIC ACID PROPARGYLGLYCINE GLYCOPEPTIDESMERCURICDIOXINODEHYDROECKOL BROMIDEZINC4-HYDROXY-2-METHYLENEBUTANOATE CHROMATESARGAHYDROQUINOICPENDIMETHALINISOSTEVIC ACID ACID 9-METHOXYCAMPTOTHECIN HUANG-LIEN-CHIEH-TU-TANGnegative regulation of insulinCYFLUTHRIN "TRIIODOTHYRONINEviral RNA replication vialearning doubleETIDRONIC"N-(1-AZABICYCLO(2.2.2)OCT-3-YL)FURO(2PR 8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINEor39 memory ACID HYPEROSIDE ALOENAPHTHYRIDINES EMODIN NIUHUANGMORPHOLINYLAMIDE negative regulation of neural cell death production COMPLEX MIXTURESPOLYETHYLENE GLYCOL 400 AMMONIUM METAVANADATE RCF-1 FIBER positive regulationLINALYL of protein ACETATE PHYCOCYANINcompound "regulationreceptorpositiveDEHYDROASCORBIC signalingregulation ofVERY circadianBRESOL LOW pathway of ACID DENSITYprotein LIPOPROTEINstranded DNA"DISODIUM intermediate (R BETA-IONONEnegative regulation of KUNTAI CAPSULE PHOSMET AMMONIUM PERCHLORATE "CONOTOXIN ALPHA-RGIA COAL TAR SODIUMASPERULOSIDE CHROMATE(VI) NIMODIPINETESTOSTERONEpositiveN-ACETYL-TYROSYL-VALYL-ALANYL-ASPARTYL regulation ENANTHATE of hairNAFCILLIN folliclePALMITOLEIC ACID1-NAPHTHYLACETYLSPERMINE OLEUROPEIN catabolic process precursor cell proliferation sleep/wakeexport from cycle nucleus TRIGLYCERIDEinterleukin-1 beta TELITHROMYCIN production DERMATOPHAGOIDESnegative regulation of heartSTREPTOMYCIN rate HYDROXYUREA PETROLEUMDEMETHOXYCURCUMIN 2-HYDROXYETHYL ACRYLATE "BENZO(A)PYRENE-1 URSOLICMANNITOL ACIDLITHOSPERMATEtranscriptionENTEROTOXINSdevelopmentSULINDACCHLOROMETHYL by RNAB SULFONEZIRAM polymerase2-(2-AMINOETHYL)PYRIDINEBRUSATOL KETONE YOHIMBINELEPTOCARPIN"negative regulation of METHANANDAMIDE PHTHALIMIDE PTERONYSSINUSresponseRIMONABANT to nutrient ANTIGEN P 2 POLY(HEXAMETHYLENEBIGUANIDINIUM)URANYL ACETATESILICIC ACID AFURESERTIB PYRIMETHANILFUREGRELATE6-NITROCHRYSENE response to exogenous dsRNATRIBUTYRIN II TUSSILAGONE
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    Organisation and transcriptional regulation of the polyphenol oxidase (PPO) multigene family of the moss Physcomitrella patens (Hedw.) B.S.G. and functional gene knockout of PpPPO1 Dissertation zur Erlangung des Doktorgrades - Dr. rer. nat. - im Department Biologie der Fakultät Mathematik, Informatik und Naturwissenschaften an der Universität Hamburg von Hanna Richter Hamburg, Januar 2009 TABLE OF CONTENTS TABLE OF CONTENTS SUMMARY...................................................................................................................5 ZUSAMMENFASSUNG...............................................................................................6 1. INTRODUCTION ................................................................................................. 8 1.1. Polyphenol oxidases ................................................................................................................ 8 1.2. Phenolic compounds ............................................................................................................. 14 1.3. The model plant Physcomitrella patens ............................................................................... 15 1.4. Aim of this research ............................................................................................................... 19 2. MATERIALS AND METHODS .......................................................................... 20 2.1. Chemicals ...............................................................................................................................
  • Flavonoid Glucodiversification with Engineered Sucrose-Active Enzymes Yannick Malbert

    Flavonoid Glucodiversification with Engineered Sucrose-Active Enzymes Yannick Malbert

    Flavonoid glucodiversification with engineered sucrose-active enzymes Yannick Malbert To cite this version: Yannick Malbert. Flavonoid glucodiversification with engineered sucrose-active enzymes. Biotechnol- ogy. INSA de Toulouse, 2014. English. NNT : 2014ISAT0038. tel-01219406 HAL Id: tel-01219406 https://tel.archives-ouvertes.fr/tel-01219406 Submitted on 22 Oct 2015 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Last name: MALBERT First name: Yannick Title: Flavonoid glucodiversification with engineered sucrose-active enzymes Speciality: Ecological, Veterinary, Agronomic Sciences and Bioengineering, Field: Enzymatic and microbial engineering. Year: 2014 Number of pages: 257 Flavonoid glycosides are natural plant secondary metabolites exhibiting many physicochemical and biological properties. Glycosylation usually improves flavonoid solubility but access to flavonoid glycosides is limited by their low production levels in plants. In this thesis work, the focus was placed on the development of new glucodiversification routes of natural flavonoids by taking advantage of protein engineering. Two biochemically and structurally characterized recombinant transglucosylases, the amylosucrase from Neisseria polysaccharea and the α-(1→2) branching sucrase, a truncated form of the dextransucrase from L. Mesenteroides NRRL B-1299, were selected to attempt glucosylation of different flavonoids, synthesize new α-glucoside derivatives with original patterns of glucosylation and hopefully improved their water-solubility.
  • Assessment of Grain Safety in Developing Nations

    Assessment of Grain Safety in Developing Nations

    ASSESSMENT OF GRAIN SAFETY IN DEVELOPING NATIONS by José Rodrigo Mendoza Jiménez A DISSERTATION Presented to the Faculty of The Graduate College at the University of Nebraska In Partial Fulfillment of Requirements For the Degree of Doctor of Philosophy Major: Food Science & Technology Under the Supervision of Professors Andréia Bianchini and Jayne E. Stratton Lincoln, Nebraska December, 2020 ASSESSMENT OF GRAIN SAFETY IN DEVELOPING NATIONS José Rodrigo Mendoza Jiménez, Ph.D. University of Nebraska, 2020 Advisor: Andréia Bianchini Grains are the most widely consumed foods worldwide, with maize (Zea mays) being frequently consumed in developing countries where it feeds approximately 900 million people under the poverty line of 2 USD per day. While grain handling practices are acceptable in most developed nations, many developing nations still face challenges such as inadequate field management, drying, and storage. Faulty grain handling along with unavoidably humid climates result in recurrent fungal growth and spoilage, which compromises both the end-quality and safety of the harvest. This becomes particularly problematic where there is little awareness about health risks associated with poor quality grain. Fungi are contaminants of maize and some can produce toxins, known as mycotoxins, that both devalue crop marketability and have detrimental health effects, especially to those malnourished. As some households depend on their harvest for self- consumption, losses due to fungi endanger their food security. To abate the threat posed by mycotoxigenic fungi on maize among developing nations, this research was conducted as a compilation of works in several countries. More specifically, it describes agricultural practices currently in use in developing nations, provides an overview of mycotoxin prevalence and approaches that can be used to improve grain safety post-harvest through proper storage.