The Effect of Bisphenol a Exposure on Mast Cell Function and Pulmonary Inflammation Associated with Asthma
The Effect of Bisphenol A Exposure on Mast Cell Function and Pulmonary Inflammation Associated with Asthma by Edmund O’Brien A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Toxicology) in The University of Michigan 2013 Doctoral Committee: Associate Professor Peter Mancuso, Co-Chair Assistant Professor Dana Dolinoy, Co-Chair Professor Cory M. Hogaboam Professor Rita Loch-Caruso Professor Bruce C. Richardson © Edmund O’Brien All Rights Reserved 2013 ACKNOWLEDGEMENTS I would like to acknowledge my committee members, Drs. Peter Mancuso, Dana C. Dolinoy, Cory M. Hogaboam, Rita Loch-Caruso, and Bruce C. Richardson, for their advice and support provided throughout my course of study. Special thanks are extended to various lab collaborators, past and present, who have aided in training, experimental design, and sample collection, including Anya Abashian, Olivia S. Anderson, Kristen A. Angel, Michael Carnegie, Sarah (Hardy) Carvaines, Jennifer Dolan, Deepti Goel, Jared Goldberg, Dr. Craig Harris, Tamara R. Jones, Marisa Mead, Muna S. Nahar, Dr. Marc Peters-Golden, Joseph Prano, Caren Weinhouse, and Dr. Zbigniew Zaslona. Thank you, Dr. Ingrid L. Bergin, Kelsey Hargesheimer, Dr. Roderick J. A. Little, Yebin Tao, Joel Whitfield, and ULAM staff for technical and supportive services. Lastly, thank you to my wonderful friend and husband, Joseph Jones, for his unconditional support. Financial support for this research came from the NIH grant HL077417 (awarded to Dr. Peter Mancuso), the Flight Attendant Medical Research Institute award CIA- 103071 (awarded to Dr. Peter Mancuso), the University of Michigan National Institutes of Environmental Health Sciences Core Center award P30 ES017885 (awarded to Dr.
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