A Feverish Imagination
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Microbe Hunters Revisited Yale University School of Medicine, New Haven, Connecticut, USA
INTERNATL MICROBIOL (1998) 1: 65-68 65 © Springer-Verlag Ibérica 1998 PERSPECTIVES William C. Summers Microbe Hunters revisited Yale University School of Medicine, New Haven, Connecticut, USA Correspondence to: William C. Summers. Yale University School of Medicine. 333 Cedar St. New Haven, CT 06520-8040. USA. Tel.: +1-203-785 2986. Fax: +1-203-785 6309. E-mail: [email protected] It was the mid-1950s and I was a teenager when I first Indeed, Microbe Hunters is a book about success: tales of read Microbe Hunters by Paul Henry De Kruif (Zealand, MI, brilliant research, incisive investigations, and heroic 1890–Holland, MI, 1971). It was the right time and the right personalities. Yet it is far from “history-objectively written.” age; I was fascinated. Here were heros enough to satisfy any The formula that De Kruif hit upon in Microbe Hunters served bookish young man interested in the natural world. Microbe him well: between 1928 and 1957 he wrote eleven more books Hunters was a book that inspired a generation or more of on medical and scientific topics, all with the same “exciting budding young microbiologists [4]. Not only that, however. narrative” and sense of drama. Some of these books were best- It established a metaphor and a genre of science writing that sellers and selected by the popular Book-of-the-Month Club. has often been imitated. None, however, matched the popularity and appeal of Microbe Microbe Hunters is a series of 12 stories that describe major Hunters. events in the history of microbiology, from microscopic De Kruif’s stories are full-scale dramatizations, complete observations of animalcules (literally “little animals”) by with fictional dialog of the historical subjects, and first person Leeuwenhoek (“First of the Microbe Hunters”) to Paul Ehrlich’s interjections of the voice of the narrator, De Kruif. -
Balcomk41251.Pdf (558.9Kb)
Copyright by Karen Suzanne Balcom 2005 The Dissertation Committee for Karen Suzanne Balcom Certifies that this is the approved version of the following dissertation: Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine Committee: E. Glynn Harmon, Supervisor Julie Hallmark Billie Grace Herring James D. Legler Brooke E. Sheldon Discovery and Information Use Patterns of Nobel Laureates in Physiology or Medicine by Karen Suzanne Balcom, B.A., M.L.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin August, 2005 Dedication I dedicate this dissertation to my first teachers: my father, George Sheldon Balcom, who passed away before this task was begun, and to my mother, Marian Dyer Balcom, who passed away before it was completed. I also dedicate it to my dissertation committee members: Drs. Billie Grace Herring, Brooke Sheldon, Julie Hallmark and to my supervisor, Dr. Glynn Harmon. They were all teachers, mentors, and friends who lifted me up when I was down. Acknowledgements I would first like to thank my committee: Julie Hallmark, Billie Grace Herring, Jim Legler, M.D., Brooke E. Sheldon, and Glynn Harmon for their encouragement, patience and support during the nine years that this investigation was a work in progress. I could not have had a better committee. They are my enduring friends and I hope I prove worthy of the faith they have always showed in me. I am grateful to Dr. -
The British Army's Contribution to Tropical Medicine
ORIGINALREVIEW RESEARCH ClinicalClinical Medicine Medicine 2018 2017 Vol Vol 18, 17, No No 5: 6: 380–3 380–8 T h e B r i t i s h A r m y ’ s c o n t r i b u t i o n t o t r o p i c a l m e d i c i n e Authors: J o n a t h a n B l a i r T h o m a s H e r r o nA a n d J a m e s A l e x a n d e r T h o m a s D u n b a r B general to the forces), was the British Army’s first major contributor Infectious disease has burdened European armies since the 3 Crusades. Beginning in the 18th century, therefore, the British to tropical medicine. He lived in the 18th century when many Army has instituted novel methods for the diagnosis, prevention more soldiers died from infections than were killed in battle. Pringle and treatment of tropical diseases. Many of the diseases that observed the poor living conditions of the army and documented are humanity’s biggest killers were characterised by medical the resultant disease, particularly dysentery (then known as bloody ABSTRACT officers and the acceptance of germ theory heralded a golden flux). Sanitation was non-existent and soldiers defecated outside era of discovery and development. Luminaries of tropical their own tents. Pringle linked hygiene and dysentery, thereby medicine including Bruce, Wright, Leishman and Ross firmly contradicting the accepted ‘four humours’ theory of the day. -
Nobel Laureate Surgeons
Literature Review World Journal of Surgery and Surgical Research Published: 12 Mar, 2020 Nobel Laureate Surgeons Jayant Radhakrishnan1* and Mohammad Ezzi1,2 1Department of Surgery and Urology, University of Illinois, USA 2Department of Surgery, Jazan University, Saudi Arabia Abstract This is a brief account of the notable contributions and some foibles of surgeons who have won the Nobel Prize for physiology or medicine since it was first awarded in 1901. Keywords: Nobel Prize in physiology or medicine; Surgical Nobel laureates; Pathology and surgery Introduction The Nobel Prize for physiology or medicine has been awarded to 219 scientists in the last 119 years. Eleven members of this illustrious group are surgeons although their awards have not always been for surgical innovations. Names of these surgeons with the year of the award and why they received it are listed below: Emil Theodor Kocher - 1909: Thyroid physiology, pathology and surgery. Alvar Gullstrand - 1911: Path of refracted light through the ocular lens. Alexis Carrel - 1912: Methods for suturing blood vessels and transplantation. Robert Barany - 1914: Function of the vestibular apparatus. Frederick Grant Banting - 1923: Extraction of insulin and treatment of diabetes. Alexander Fleming - 1945: Discovery of penicillin. Walter Rudolf Hess - 1949: Brain mapping for control of internal bodily functions. Werner Theodor Otto Forssmann - 1956: Cardiac catheterization. Charles Brenton Huggins - 1966: Hormonal control of prostate cancer. OPEN ACCESS Joseph Edward Murray - 1990: Organ transplantation. *Correspondence: Shinya Yamanaka-2012: Reprogramming of mature cells for pluripotency. Jayant Radhakrishnan, Department of Surgery and Urology, University of Emil Theodor Kocher (August 25, 1841 to July 27, 1917) Illinois, 1502, 71st, Street Darien, IL Kocher received the award in 1909 “for his work on the physiology, pathology and surgery of the 60561, Chicago, Illinois, USA, thyroid gland” [1]. -
Microbe Hunters Revisited •Fi Paul De Kruif and the Beginning of Popular
The Texas Medical Center Library DigitalCommons@TMC John P. McGovern Historical Collections and Houston History of Medicine Lectures Research Center 3-7-2012 Microbe Hunters Revisited – Paul de Kruif and the Beginning of Popular Science Writing Stephen Greenberg Baylor College of Medicine Follow this and additional works at: https://digitalcommons.library.tmc.edu/homl Part of the History of Science, Technology, and Medicine Commons, and the Medicine and Health Sciences Commons Recommended Citation Citation Information:Greenberg, Stephen, "Microbe Hunters Revisited – Paul de Kruif and the Beginning of Popular Science Writing" (2012). DigitalCommons@TMC, John P. McGovern Historical Collections and Research Center, Houston History of Medicine Lectures. Paper 7. https://digitalcommons.library.tmc.edu/homl/7 This Article is brought to you for free and open access by the John P. McGovern Historical Collections and Research Center at DigitalCommons@TMC. It has been accepted for inclusion in Houston History of Medicine Lectures by an authorized administrator of DigitalCommons@TMC. For more information, please contact [email protected]. Houston History of Medicine Microbe Hunters Revisited March 7, 2011 Microbe Hunters Revisited – Paul de Kruif and the Beginning of Popular Science Writing Date: March 7, 2012 Speaker: Stephen Greenberg, M.D., Dean of Medical Education, Baylor College of Medicine Abstract: Paul de Kruif is credited with being one of the first popular science writers for the general public. He received his Ph.D. from the University of Michigan in 1916 and worked at the Rockefeller Institute under Simon Flexner. After being fired in 1922 for publishing a scathing article on medical research, de Kruif caught the attention of Sinclair Lewis, who used his scientific background to write his Pulitzer Prize winning novel, Arrowsmith. -
2-Microbe-Hunters-Paul-De-Kruif.Pdf
Microbe Hunters Paul de Kruif To RHEA A Harvest/HBJ Book Harcourt Brace Jovanovich, Publishers San Diego New York London Copyright 1926 by Paul de Kruif Copyright renewed 1954 by Paul de Kruif All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Table of Contents 1. LEEUWENHOEK: First of the Microbe Hunters 2. SPALLANZANI: Microbes Must Have Parents! 3. PASTEUR: Microbes Are a Menace! 4. KOCH: The Death Fighter 5. PASTEUR: And the Mad Dog 6. ROUX AND BEHRING: Massacre the Guinea-Pigs 7. METCHNIKOFF: The Nice Phagocytes 8. THEOBALD SMITH: Ticks and Texas Fever 9. BRUCE: Trail of the Tsetse 10. ROSS VS. GRASSI: Malaria 11. WALTER REED: In the Interest of Science-and for Humanity! 12. PAUL EHRLICH: The Magic Bullet Footnotes Books by Paul de Kruif 1. LEEUWENHOEK: First of the Microbe Hunters 1 Two hundred and fifty years ago an obscure man named Leeuwenhoek looked for the first time into a mysterious new world peopled with a thousand different kinds of tiny beings, some ferocious and deadly, others friendly and useful, many of them more important to mankind than any continent or archipelago. Leeuwenhoek, unsung and scarce remembered, is now almost as unknown as his strange little animals and plants were at the time he discovered them. This is the story of Leeuwenhoek, the first of the microbe hunters. It is the tale of the bold and persistent and curious explorers and fighters of death who came after him. -
Nobel Laureates in Physiology Or Medicine
All Nobel Laureates in Physiology or Medicine 1901 Emil A. von Behring Germany ”for his work on serum therapy, especially its application against diphtheria, by which he has opened a new road in the domain of medical science and thereby placed in the hands of the physician a victorious weapon against illness and deaths” 1902 Sir Ronald Ross Great Britain ”for his work on malaria, by which he has shown how it enters the organism and thereby has laid the foundation for successful research on this disease and methods of combating it” 1903 Niels R. Finsen Denmark ”in recognition of his contribution to the treatment of diseases, especially lupus vulgaris, with concentrated light radiation, whereby he has opened a new avenue for medical science” 1904 Ivan P. Pavlov Russia ”in recognition of his work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged” 1905 Robert Koch Germany ”for his investigations and discoveries in relation to tuberculosis” 1906 Camillo Golgi Italy "in recognition of their work on the structure of the nervous system" Santiago Ramon y Cajal Spain 1907 Charles L. A. Laveran France "in recognition of his work on the role played by protozoa in causing diseases" 1908 Paul Ehrlich Germany "in recognition of their work on immunity" Elie Metchniko France 1909 Emil Theodor Kocher Switzerland "for his work on the physiology, pathology and surgery of the thyroid gland" 1910 Albrecht Kossel Germany "in recognition of the contributions to our knowledge of cell chemistry made through his work on proteins, including the nucleic substances" 1911 Allvar Gullstrand Sweden "for his work on the dioptrics of the eye" 1912 Alexis Carrel France "in recognition of his work on vascular suture and the transplantation of blood vessels and organs" 1913 Charles R. -
A Zoologist for Malaria*
187-324 Contributios 3.2 4/5/07 08:40 Página 187 CONTRIBUTIONS to SCIENCE, 3 (2): 187–195 (2006) Institut d’Estudis Catalans, Barcelona DOI: 10.2436/20.7010.01.5 ISSN: 1575-6343 www.cat-science.com focus Battista Grassi: a zoologist for malaria* E. Capanna** Museo di Anatomia Comparata “Battista Grassi” Università di Roma “La Sapienza” e Centro Linceo Interdisciplinare “Beniamino Segre”, Accademia Nazionale dei Lincei, Roma, Italy Malaria is probably one of the oldest diseases, and it has been tion of natural resources and accordingly lower economic prof- the scourge of populations in tropical and temperate-hot areas its. Therefore, prominent scientists decided to tackle the prob- of the world since antiquity. It is also known by its French term, lem of “paludisme” in France and in Great Britain. Of these, the paludisme although the Italian name, malaria, more accurately three who were the most important for our story are described. describes the disease. The Italian term refers to mala aria, bad Charles Louis Alphonse Laveran (1845–1922) was a military air, i.e., the miasmas evaporating from the stagnant waters of physician in Algeria when, on 6 November 1880, at the age of marshes, which the ancients believed were the origin of the 33, he described malarial parasites in the blood of patients dur- disease. It was not until the second half of the nineteenth cen- ing malarial fever episodes (Laveran, 1880, 1881). He called tury that scientists started to search for the agent that gave rise this microscopic organism Oscillaria malariae. The discovery to malaria. -
Science Vision 17, 33-52 (2017)
Science Vision 17, 33-52 (2017) Available at SCIENCE VISION www.sciencevision.org SCIENCE VISION Historical Research OPEN ACCESS The making of oncology: The tales of false carcinogenic worms K. Lalchhandama Department of Zoology, Pachhunga University College, Aizawl 796001, Mizoram, India Cancer is a disease of antiquity. The Ancient Greeks were familiar with onkos (from Received 23 January 2017 Accepted 15 February 2017 which we have the term oncology)—tumour of all sorts. Hippocrates coined karki- nos and karkinoma, our source of the words cancer and carcinoma. Of a plethora *For correspondence : of carcinogens, parasitic worms (helminths) constitute a considerable health con- [email protected] cern. Three trematodes, Clonorchis sinensis, Opisthorchis viverrini, and Schisto- soma haematobium are now officially classified carcinogens. But the discovery of helminths as cancer-causing agents took wrong turns and marks an inglorious chapter in the history of science. The carcinogenicity of worms, vindicating Rudolf Virchow’s reiztheorie (irritation theory) of cancer origin, was glorified in the scien- tific forefront by Johannes Fibiger in the 1910s. Discovery of a new nematode, which he proudly named Spiroptera carcinoma, and his subsequent demonstration that the parasite could induce stomach cancer in rats, earned Fibiger a retrospec- tive Nobel Prize in Physiology or Medicine in 1926, and a lasting fame. But not in an appealing way. His achievement did not withstand the test of time. S. carci- noma was annulled as an invalid taxon in zoology—supplanted by Gongylonema neoplasticum—and eventually was branded as a non-carcinogenic agent. Contact us : [email protected] Key words: Gongylonema neoplasticum; helminth; Fibiger; cancer; Nobel Prize. -
List of Nobel Laureates 1
List of Nobel laureates 1 List of Nobel laureates The Nobel Prizes (Swedish: Nobelpriset, Norwegian: Nobelprisen) are awarded annually by the Royal Swedish Academy of Sciences, the Swedish Academy, the Karolinska Institute, and the Norwegian Nobel Committee to individuals and organizations who make outstanding contributions in the fields of chemistry, physics, literature, peace, and physiology or medicine.[1] They were established by the 1895 will of Alfred Nobel, which dictates that the awards should be administered by the Nobel Foundation. Another prize, the Nobel Memorial Prize in Economic Sciences, was established in 1968 by the Sveriges Riksbank, the central bank of Sweden, for contributors to the field of economics.[2] Each prize is awarded by a separate committee; the Royal Swedish Academy of Sciences awards the Prizes in Physics, Chemistry, and Economics, the Karolinska Institute awards the Prize in Physiology or Medicine, and the Norwegian Nobel Committee awards the Prize in Peace.[3] Each recipient receives a medal, a diploma and a monetary award that has varied throughout the years.[2] In 1901, the recipients of the first Nobel Prizes were given 150,782 SEK, which is equal to 7,731,004 SEK in December 2007. In 2008, the winners were awarded a prize amount of 10,000,000 SEK.[4] The awards are presented in Stockholm in an annual ceremony on December 10, the anniversary of Nobel's death.[5] As of 2011, 826 individuals and 20 organizations have been awarded a Nobel Prize, including 69 winners of the Nobel Memorial Prize in Economic Sciences.[6] Four Nobel laureates were not permitted by their governments to accept the Nobel Prize. -
Book Review Section Show Clearly Is How Effective Burnet Actually Publishers, 1991 (Australasian Studies in Was in This Role
stirrer of public consciousness on a number Book Review of issues - a man with opinions on every- thing from uranium mining to eugenics, from Section smoking to medical education - with an inclination to put his arguments forcibly and with an authority that guaranteed that his Compiled by John Jenkin* views could not be ignored. Many of Australia's immunologists and microbiologists knew Burnet. These scien- Christopher Sexton, The Seeds of Time: tists will read the book out of interest rather The Life of Sir Macfarlane Burnet. Mel- than to find out more about him; they may bourne: Oxford University Press, 1991. x + hope that the book will do nothing to dimin- 301 pp., illus., $39.95. ish the image of a man they held in admi- ration. From people who knew Burnet, I have Sir (Frank) Macfarlane Burnet was a great heard generally favourable comments. biological scientist. He was responsible for The second group of readers comprises several major technical developments and Australian scientists who did not know Bur- conceptual insights in his first field of net, and that is my own perspective. To an research, virology, and for two conceptual immunologist who came to Australia after breakthroughs in his second, immunology. Burnet had retired, a life of Burnet holds His work was seminal - many of the impor- particular interest. The question has arisen tant steps leading to the development of viral amongst younger and emigre immunologists vaccines can be traced back to techniques whether the continuing focus on Burnet is worked up by Burnet, and much of the excit- unhealthy; but the evidence is that Austra- ing cellular and molecular immunology of the lian immunology is healthy in its diversity, last twenty years consists of answers to ques- that it has plenty of leadership, and that the tions that make sense only in the context of tribute to Burnet results from a mixture of Burnet's theories. -
Nobel Prizes List from 1901
Nature and Science, 4(3), 2006, Ma, Nobel Prizes Nobel Prizes from 1901 Ma Hongbao East Lansing, Michigan, USA, Email: [email protected] The Nobel Prizes were set up by the final will of Alfred Nobel, a Swedish chemist, industrialist, and the inventor of dynamite on November 27, 1895 at the Swedish-Norwegian Club in Paris, which are awarding to people and organizations who have done outstanding research, invented groundbreaking techniques or equipment, or made outstanding contributions to society. The Nobel Prizes are generally awarded annually in the categories as following: 1. Chemistry, decided by the Royal Swedish Academy of Sciences 2. Economics, decided by the Royal Swedish Academy of Sciences 3. Literature, decided by the Swedish Academy 4. Peace, decided by the Norwegian Nobel Committee, appointed by the Norwegian Parliament, Stortinget 5. Physics, decided by the Royal Swedish Academy of Sciences 6. Physiology or Medicine, decided by Karolinska Institutet Nobel Prizes are widely regarded as the highest prize in the world today. As of November 2005, a total of 776 Nobel Prizes have been awarded, 758 to individuals and 18 to organizations. [Nature and Science. 2006;4(3):86- 94]. I. List of All Nobel Prize Winners (1901 – 2005): 31. Physics, Philipp Lenard 32. 1906 - Chemistry, Henri Moissan 1. 1901 - Chemistry, Jacobus H. van 't Hoff 33. Literature, Giosuè Carducci 2. Literature, Sully Prudhomme 34. Medicine, Camillo Golgi 3. Medicine, Emil von Behring 35. Medicine, Santiago Ramón y Cajal 4. Peace, Henry Dunant 36. Peace, Theodore Roosevelt 5. Peace, Frédéric Passy 37. Physics, J.J. Thomson 6. Physics, Wilhelm Conrad Röntgen 38.