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Curriculum Vitae Professor Dr. Martin J. Lohse

Name: Martin J. Lohse Born: 26 August 1956 in

Research Interests: Receptor , Receptor , Molecular of receptor functions

Academic and professional career Since 2003 Managing Director of the Julius Maximilian University of Würzburg Graduate Schools Since 1993 Professor and Chairman of the Institute of Pharmacology and Toxicology at the University of Würzburg 1990 ‐ 1993 Working group leader at the Laboratory of in the Gene Center of the Ludwig Maximilian University of and the Max Planck Institute of in 1990 Assistant Professor, medical research, Duke University, Durham, US 1990 Certified as medical specialist in pharmacology and toxicology 1988 ‐ 1990 Research Associate at the Howard Hughes Medical Institute of Duke University, Durham, US 1988 Obtained post‐doctoral teaching qualification in pharmacology and toxicology from University 1983 ‐ 1987 Research Assistant at the pharmacology institutes of the universities of and Heidelberg 1978 ‐ 1981 Completed dissertation in neurobiology at the Max Planck Institute for Biophisical in Göttingen; obtained doctorate from Göttingen University (1981) 1974 ‐ 1981 Studied and in Göttingen, London and Paris; passed state examination in medicine (1981)

Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 1 Project coordination, membership in collaborative research projects (selection) Since 2001 Founding Speaker of the DFG Research Centre for Experimental Biomedicine, the Rudolf Virchow Center, University of Würzburg 2000 ‐ 2011 Founding Speaker (Vice‐Speaker since 2005) of Collaborative Research Centre (CRC) 487, Regulatory Membrane Proteins, University of Würzburg 1995 ‐ 1999 Member of the Speakers’ Council of CRC 176 – Molecular Basis of Signal Transduction and Membrane Transport 1994 ‐ 2004 Member of the Speakers’ Council of CRC 355 – Pathophysiology of Heart Failure 1994 ‐ 1999 Member of the DFG Speaker’s Committee focusing on GTPases 1993 ‐ 1996 Coordinator of the EU’s biotechnology programme Molecular Mechanisms of Receptor Function (EUROCEPTOR) 1993 ‐ 1996 Member of the EU’s biomedicine programme Adenosine Receptors 1986 ‐ 1989 Coordinator of Adenosine Receptor Ligands, European Science Foundation

Functions in academic societies and committees (selection) Since 2009 Vice‐President of the German National Academy of Sciences Leopoldina, (Saale) Since 2009 Vice‐President for Research, University of Würzburg Since 2009 Max Planck Society: Member of the Presidential Committee of the International Max Planck Research Schools Since 2009 Member of the board of trustees of the Research and Science Foundation Since 2009 Member of the board of trustees of the Protestant Institute for Interdisciplinary Research, Heidelberg Since 2008 Chairman of the advisory board of the Institute for Functional Genomics, Montpellier, France Since 2008 Chairman of the advisory board of the Institute of Molecular Medicine, Toulouse, France 2007 ‐ 2008 Chairman of the advisory board of the Rangueil Institute of Molecular Medicine, Toulouse, France 2007 ‐ 2009 Member of the senate and university council of the University of Würzburg Since 2006 Vice‐Dean of the Graduate School of Life Sciences of the University of Würzburg 2006 ‐ 2010 Member of the DFG’s Excellence Initiative Grants Committee and the Research Council 2004 ‐ 2009 Vice‐Dean of research at the University of Würzburg Medical Faculty Since 2004 Member of the advisory board of the European Liaison Office of the German Research Organisations (KoWi), Brussels; Chairman since 2009 Since 2003 Founding Director of the University of Würzburg Graduate Schools 2003 ‐ 2008 Member of the National Ethics Council 2001 ‐ 2009 Member of the DFG Commission on Clinical Research

Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 2 2001 ‐ 2007 Member of the DFG Senate and Joint Committee 2001 Chairman of the advisory board of the Austrian Academy of Sciences, Life Science Institute 2000 ‐ 2003 Chairman of the Pharmacology Section of the German Society for Experimental and Clinical Pharmacology and Toxicology 2000 ‐ 2001 Chairman of the Physical‐Medical Society of Würzburg 1999 ‐ 2011 Member and Chairman (from 2006 to 2011) of the scientific advisory boards of the Robert Bosch Hospital and the Institute for Clinical Pharmacology, Robert Bosch Foundation Since 1998 Member of the scientific advisory boards of various biotech companies: ProCorde/Trigen AG from 2000 to 2005 (Chairman); Cardion AG from 2002 to 2003; bioLeads GmbH from 1998 to 2003 1998 ‐ 2003 Liaison lecturer for the German National Academic Foundation (Studienstiftung des Deutschen Volkes) 1996 ‐ 2003 Expert consultant of the DFG for pharmacology and toxicology and Deputy Chairman of the Expert Committee on Theoretical Medicine Since 1995 Member of various foundations’ boards and prize committees (the Wollheim and Yael foundations; the Eppendorf and Wilhelm Vaillant prizes) 1992 ‐ 1994 International Human Frontier Science Program, Chairman of the Review Committee Molecular Mechanisms Since 1990 Reviewer and committee member of numerous scientific organisations (e.g. AvH, BMBF, GIF, EU, ESF; AERES, ANR, CNRS, INSERM, NIH, NSF, ÖAW, SNF, Telethon, Wellcome Trust) Since 1985 Reviewer for numerous journals (e.g. Nature and Nature Journals (medicine, , methods, chemical biology, communications), Science Signaling, Cell and Cell Journals, PNAS, JCB, Circulation, Circulation Research, Molecular Pharmacology, The EMBO Journal) Participation in several ad hoc advisory committees for governments, ministries, funding bodies, research institutions and universities both in and abroad

Company founder 2012 advanceCOR GmbH, Martinsried 2007 Corimmun GmbH, Martinsried 2000 ProCorde GmbH (Trigen GmbH since 2005), Martinsried

Honours and awarded memberships (selection) 2013 Member of the Academia Europaea 2012 Svedberg Lecturer at Uppsala University, Sweden 2012 Vallee Foundation Professor, Harvard Medical School, Boston (MA) 2010 Jacob Henle Medal of Georg‐August‐Universität Göttingen

Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 3 2009 Ariëns Award of the Dutch Pharmacological Society 2008 Land of Ideas school labs at the Rudolf Virchow Center 2008 Advanced Investigator Grant of the European Research Council 2007 Research Achievement Award of the International Society for Heart Research 2006 Bavarian Order of Merit 2005 PR Report Award for Rudis Forschercamp children’s research camp 2004 Corresponding member of the North Rhine‐Westphalia Academy of Sciences, Humanities and the Arts 2002 Federal Cross of Merit, First Class 2000 Ernst Jung Prize for Medicine 2000 Member of the German National Academy of Sciences Leopoldina 1999 Gottfried Wilhelm Leibniz Prize of the German Research Foundation 1998 Member of the Bavarian Academy of Sciences and Humanities 1997 Scientific committee of the Chaire Pierre Dumont of the Université catholique de Louvain, Belgium 1996 Wilhelm Vaillant Prize 1991 Research Award of the Federal Ministry of Health 1990 Heisenberg Fellowship / Gerhard Hess Prize of the German Research Foundation 1987 Claudius Galenus Prize (known today as the Galenus von Pergamon Prize) 1986 Fritz Külz Prize

Main research interests

 Receptor physiology

 Receptor pharmacology

 Molecular biology of receptor functions (intracellular signal transduction and its retroactive desensitising effect on receptors; adrenergic and parathyroid hormone receptors; the role of the β1 adrenoreceptor in heart failure)

Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 4