Fakultät für Chemie und Pharmazie ResearchResearch ReportReport 2016–20172016–2017 14 I Research Report Faculty of Chemistry and Pharmacy 2016 - 2017 Volume 14 Ludwig-Maximilians-Universität München II Publisher: Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München München, 2018 Group leaders are responsible for the contents. Co-ordination: Gertrud Adelmann Office of the Dean Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München Butenandtstr. 5–13 (Haus F), 81377 München Print: Hansa Print Service GmbH ein Unternehmen der Wenzel-Gruppe Thalkirchner Str. 72 80337 München III Dear Reader: Our Faculty has been putting together a research report biennially since 1988 doc- umenting the research activities of its three Departments. This report may also be viewed on the Faculty’s website under http://www.cup.lmu.de</de/forschung. Important factors for conducting successful research have been the establishment of new key professorships, an example of which was the professorship for the Didac- tics of Chemistry, organized through successful applications to various programs one of which was the European Research Council. Among the special awards granted for the work of our faculty members were the Leibniz Prize of the German Research Foundation as well as a European Research Council Advanced Grant for the Chemistry and Biochemistry Departments. Numerous promising young re- searchers, both women and men, have received further honors or have been offered academic positions at renowned research institutions. Our donors, whom we thank for their engagement in the Römer- and Marcinek Endowments, have made another important contribution to the maintenance of a stimulating research climate. To assure future progress, we are currently building new premises for researchers at the new Institute for Chemical Epigenetics Munich (ICEM). The training of young academics is especially important to foster creative and com- petitive research. Within the last two years, the quality of our study programs has been officially recognized through accreditation and the education of our students has profited by grants from the State and from the Contract for Quality in Teaching (Qualitätspakt Lehre). Personal responsibility, high motivation and drive are the characteristics of our teaching staff, doctoral assistants, students and faculty employees, all of whom have contributed to the outstanding results documented in this report. My thanks to all members of the Faculty, the President’s Office and the State of Bavaria. Dean of Faculty of Chemistry and Pharmacy IV The following belong to the Faculty of Chemistry and Pharmacy: Department of Biochemistry Feodor-Lynen-Straße 25, Haus A 81377 München tel. 089/2180-0 Department of Chemistry Butenandtstraße 5–13 81377 München tel. 089/2180-0 Inorganic Chemistry: Haus D Organic Chemistry: Haus F Physical Chemistry: Haus E Theoretical Chemistry: Haus E and B Department of Pharmacy – Center for Pharmaceutical Research Butenandtstr. 5–13 81377 München tel. 089/2180-0 Pharmaceutical/Medicinal/Biological Chemistry: Haus C Pharmaceutical Biology and Biotechnology: Haus B and D Pharmaceutical Technology and Biopharmaceutics: Haus B Pharmacology: Haus C V Inorganic Chemistry Pages Beck, Wolfgang 2–3 Böttcher Hans-Christian 4–5 Bräuniger, Thomas 6–7 Daumann, Lena 8–9 Hoch, Constantin 10–11 Johrendt, Dirk 12–14 Karaghiosoff, Konstantin 15–20 Klapötke, Thomas 21–29 Klüfers, Peter 30–34 Kornath, Andreas 35–36 Lotsch, Bettina 37–42 Schnick, Wolfgang 43–47 Schwarzer, Stefan 48–49 Stierstorfer, Jörg 50–51 Sünkel, Karlheinz 52 Biochemistry Beckmann, Roland 53–57 Canzar, Stefan 58–59 Conti, Elena 60–62 Fässler, Reinhold 63–65 Förstemann, Klaus 66–67 Gaul, Ulrike 68–70 Hartl, F. Ulrich 71–74 Hopfner, Karl-Peter 75–78 Jae, Lucas 79–80 Mann, Matthias 81–89 Schäffner, Anton 90–91 Stingele, Julian 92 Turck, Christoph 93–95 Wilson, Daniel 96–99 VI Organic Chemistry Carell, Thomas 100–103 Didier, Dorian 104–105 Dube, Henry 106–107 Hoffmann-Röder, Anja 108–109 Kellner, Stefanie 110–111 Knochel, Paul 112–118 Langhals, Heinz 119–121 Linser, Rasmus 122–124 Magauer, Thomas 125–126 Mayr, Herbert 127–129 Ofial, Armin 130–131 Trapp, Oliver 132–135 Zipse, Hendrik 136–138 Physical Chemistry Bein, Thomas 139–146 Bräuchle, Christoph 147–150 Ebert, Hubert 151–156 Engelke, Hanna 157–158 Hartschuh, Achim 159–160 Jagau, Thomas-Christian 161–162 Ochsenfeld, Christian 163–167 Tinnefeld, Philip 168–169 de Vivie-Riedle, Regina 170–173 Wintterlin, Joost 174–175 VII Pharmaceutical/Medicinal/Biological Chemistry Bracher, Franz 176–180 Huc, Ivan 181–184 Thorn-Seshold, Oliver 185 Wanner, Klaus 186–189 Pharmaceutical Biology and Biotechnology Lächelt, Ulrich 190–192 Pachmayr, Johanna 193–194 Vollmar, Angelika 195–199 Wagner, Ernst 200–206 Zahler, Stefan 207–209 Pharmaceutical Technology and Biopharmaceutics Engert, Julia 210–211 Frieß, Wolfgang 212–214 Merkel, Olivia 215–217 Winter, Gerhard 218–221 Pharmacology Biel, Martin 222–227 Grimm, Christian Michael 228–229 Michalakis, Stylianos 230–233 Wahl-Schott, Christian 234–237 2 Inorganic Chemistry Univ-Prof. Dr. rer.nat. Dr. h.c. Wolfgang Beck, em. Born 1932 in München, study of chemistry at Technische Hochschule München (now TUM), 1960 PhD degree with Professor Walter Hieber, 1963 Habilitation and Privatdozent at TH München, since 1968 o. Professor and Vorstand of Institut für Anorganische Chemie LMU München, 1973-1974 Dean of Fakultät für Chemie und Pharmazie, 1977 Guest Professor at University of Wisconsin, Madison, 1992- 1994 Member of Senat and Versammlung at LMU, 1981-1992 Referee of Deutsche Forschungsgemeinschaft, since 2000 Emeritus, 2011 Dr. h.c. TU München. Research Topics Organometallic and Coordination Chemistry. History of Chemistry at LMU Honors, Awards, Memberships GDCH, American Chemical Society, The Royal Society of Chemistry Publications - Scientific Papers Peter M. Fritz and Wolfgang Beck. Organometallic Lewis Acids LX. Pentacarbon- + – ylrhenium Complexes [(OC)5Re-L] BF4 with N-Donor Ligands L = Tetrazole, Dimethylaminopyridine (DMAP), Triphenyliminophosphoranes and with Triphenylphosphine Oxide. Z. Anorg. Allg. Chem. 2017, 643, 224-226. Peter M. Fritz and Wolfgang Beck. Organometallic Lewis Acids LXI. + – Pentacarbonylrhenium Complexes [(OC)5Re-L] BF4 with Aromatic Amines (L) ás Ligands. Z. Anorg. Allg. Chem. 2017, 643, 225-227. Wolfgang Beck, Gerd Fischer and Peter Swoboda, Some Comments on Fulminic Acid (Knallsäure) and a Praise to Heinrich Wieland and his Work on Organic De- rivatives of Nitrogen. Z. Anorg. Allg. Chem. 2017, 643, 353-356. 3 Barbara Wagner-Schuh and Wolfgang Beck. Metal Complexes of Biological Im- portant Ligands CLXXVII. Dichlorido Platinum(II) and Palladium(II) Complexes with Long Chain Amino Acids and Amino Acid Amides. Z. Anorg. Allg. Chem. 2017, 643, 632-635. Christopher U. Missling, Karlheinz Sünkel, Heinz Langhals and Wolfgang Beck. Organometllic Lewis Acids, Part LXII. Chiral Carbonyl-Cyclopentadienyl- Triphenylphosphine-Iron and –Ruthenium Complexes with Tertiary Nitriles + – [CpM(CO)(PPh3)(N{C-CR1R2R3)] BF4 . Z. Anorg. Allg. Chem. 2017, 643, 1262-1268. Martin J. Schweiger and Wolfgang Beck. Metal Complexes of Biologically Im- portant Ligands CLXXVIII. Addition of the Pentacarbonylrhenium Cation [(OC) + 5Re] to the Xanthine Alkaloids Caffeine, Theophylline and Theobromine. Z. Anorg. Allg. Chem. 2017, 643, 1335- 1337. Hans-Christian Böttcher and Wolfgang Beck. Reaction behavior of the Collman reagent towards the nitrosyl carbonyls [CoNO(CO)3] and [Fe(NO)2(CO)2]. Z. Naturforsch. 2017, 72 b, 457-460. 4 Inorganic Chemistry Apl. Prof. Dr. rer. nat. Hans-Christian Böttcher Born in 1957 in Zwickau, 1978-1983 studied chemistry at the Martin Luther Uni- versity Halle-Wittenberg, 1985 PhD degree in the group of B. Walther (metal- clus- ter chemistry), scientific assistant at the University of Halle, 1991-1992 postdoctor- al fellow in the group of Prof. G. Süss-Fink at the University of Neuchâ- tel/Switzerland (homogenous catalysis), 1992-1993 research in homogenous cataly- sis for BASF-AG/Ludwigshafen (at the University of Neuchâtel), 1995 research in the group of Prof. R. Schmutzler (Technical University of Braunschweig), 1996 habilitation at the University of Halle (coordinatively unsaturated metal-cluster compounds), privatdozent (C2) in Halle, 1999 interim professor (C4) at the Univer- sity of Karlsruhe (TH), since 2004 scientific assistant at the Department of Chemis- try at LMU Munich (group of Prof. P. Klüfers), since 2005 privatdozent in Munich, since 2011 apl. prof. at the Department of Chemistry in Munich. Research Topics Fixation and activation of small molecules in the coordination sphere of di- and multinuclear metal carbonyl complexes. Protonation of metal-metal bonds in dinu- clear metal complexes. Synthesis of coordination compounds containing nitrosyl ligands. Hyponitrito complexes as model compounds of active sites in processes of enzymatic nitric oxide reductases (NOR). Studies of dynamic effects in complexes with sterically demanding phosphane ligands using NMR spectroscopy (rhodium, iridium). Honors, Awards, Memberships Member of the Gesellschaft Deutscher Chemiker Publications Scientific Papers Synthesis and Molecular Structure of trans-[RhCl(NO)(PtBu2H)2]BF4. H.-C. Böt- tcher, P. Mayer, Z. Anorg Allg. Chem. 2016, 642, 299301. 5 Synthesis and Molecular Structure of trans-[IrCl(NO)(PtBu2H)2]BF4. H.-C. Böt- tcher, T. Mies, P. Mayer, Z. Anorg Allg. Chem. 2016, 642, 793795. Reaction Behavior of Decacarbonyldimetalates(2)