The Physiologist Also Receive Abstracts of the Conferences of the Tsien and Reuter Elected American Physiological Society
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Myosin II Reactivation and Cytoskeletal Remodeling As a Hallmark and a Vulnerability in Melanoma Therapy Resistance
Article Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance Graphical Abstract Authors Jose L. Orgaz, Eva Crosas-Molist, Amine Sadok, ..., actin-Myosin dynamics Sophia N. Karagiannis, Ilaria Malanchi, Victoria Sanz-Moreno transcriptional re-wiring cytoskeleton ROCK-Myosin II- Correspondence remodeling addicted tumor [email protected] (J.L.O.), MAPKi [email protected] (V.S.-M.) MAPKi anti-PD-1 MAPK Myosin II Cross-resistant ROCK/Myosin II In Brief phenotype inhibition Orgaz et al. show that myosin II activity ROCK/Myosin II ROCK/Myosin II increases during melanoma adaptation to PD-L1 ROS PD-L1 ROS MAPK pathway inhibition. ROCK-myosin II signaling supports survival of resistant p-H2A.X melanoma cells and promotes immunosuppression. ROCK inhibitors FOXP3+ + Treg CD206+ CD206 improve the efficacy of MAPK inhibitors CD206+ φ FOXP3+ Mφ M Mφ Treg and immunotherapies in melanoma FOXP3+ FOXP3+ + + CD206 Treg Treg CD206 φ + M + CD206 Mφ models. + CD206 φ FOXP3 φ M Treg M Highlights d Therapy-resistant melanoma cells restore myosin II activity to increase survival d High myosin II activity identifies targeted and immunotherapy-resistant melanomas d ROCK-myosin II inhibition increases ROS-DNA damage and decreases PD-L1 and Tregs d ROCK inhibition enhances efficacy of MAPK inhibitors and immunotherapies Orgaz et al., 2020, Cancer Cell 37, 85–103 January 13, 2020 ª 2019 The Authors. Published by Elsevier Inc. https://doi.org/10.1016/j.ccell.2019.12.003 Cancer Cell Article Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance Jose L. -
FIA Usage Interne Surname First Name Categorization Abbott Hunter
2016 DRIVERS' CATEGORIZATION LIST Valid as from 1st January 2016 Drivers in red : revised categorization Drivers in blue : new categorization Surname First name Categorization Abbott Hunter Bronze Abelli Julien Silver Abergel Gabriele Bronze Abra Richard Silver Abreu Attila Gold Abril Vincent Gold Abt Daniel Gold Accary Thomas Silver Adam Jonathan Gold Adams Rudi Bronze Aeberhard Juerg Silver Afanasiev Sergei Silver Aguas Rui Silver Ahrabian Darius Bronze Ajlani Karim Bronze Aksenov Stanislas Silver Al-Azhari Karim Bronze Al Faisal Abdulaziz Silver Al Harthy Ahmad Bronze Al Masaood Humaid Bronze Al Qubaisi Khaled Bronze Albers Christijan Platinum Albert Michael Silver Albuquerque Filipe Platinum Alder Brian Silver Aleshin Mikhail Platinum Alessi Diego Silver Alexander Iradj Silver Alguersuari Jaime Platinum Alleman Cyndie Silver Allemann Daniel Bronze Allgàuer Egon Bronze Allmendinger AJ Gold Almond Michael Silver Almudhaf Khaled Bronze Altenburg Jeff Silver FIA Usage Interne Surname First name Categorization Altevogt Peter Bronze Al-Thani Abdulrahman Silver Aluko Kolawole Bronze Alvarez Juan Cruz Silver Alzen Uwe Gold Amado Ulric Gold Amaral Miguel Bronze Amberg Zoel Gold Ammermüller Michael Gold Amos Eugenio Silver Anapoli Giovanni Bronze Andersen Dennis Bronze André Didier Silver Andreasi Paolo Bronze Ang Dominic Silver Ang Gilbert Ding Feng Silver Angelelli Massimiliano Gold Annala Juho Gold Antinucci Richard Silver Antunes Nathan Silver Apicella Marco Gold Appleby James Silver Ara Seiji Gold Ardagna Perez Gaetano Bronze Arzeno Mathieu -
Date: To: September 22, 1 997 Mr Ian Johnston©
22-SEP-1997 16:36 NOBELSTIFTELSEN 4& 8 6603847 SID 01 NOBELSTIFTELSEN The Nobel Foundation TELEFAX Date: September 22, 1 997 To: Mr Ian Johnston© Company: Executive Office of the Secretary-General Fax no: 0091-2129633511 From: The Nobel Foundation Total number of pages: olO MESSAGE DearMrJohnstone, With reference to your fax and to our telephone conversation, I am enclosing the address list of all Nobel Prize laureates. Yours sincerely, Ingr BergstrSm Mailing address: Bos StU S-102 45 Stockholm. Sweden Strat itddrtSMi Suircfatan 14 Teleptelrtts: (-MB S) 663 » 20 Fsuc (*-«>!) «W Jg 47 22-SEP-1997 16:36 NOBELSTIFTELSEN 46 B S603847 SID 02 22-SEP-1997 16:35 NOBELSTIFTELSEN 46 8 6603847 SID 03 Professor Willis E, Lamb Jr Prof. Aleksandre M. Prokhorov Dr. Leo EsaJki 848 North Norris Avenue Russian Academy of Sciences University of Tsukuba TUCSON, AZ 857 19 Leninskii Prospect 14 Tsukuba USA MSOCOWV71 Ibaraki Ru s s I a 305 Japan 59* c>io Dr. Tsung Dao Lee Professor Hans A. Bethe Professor Antony Hewlsh Department of Physics Cornell University Cavendish Laboratory Columbia University ITHACA, NY 14853 University of Cambridge 538 West I20th Street USA CAMBRIDGE CB3 OHE NEW YORK, NY 10027 England USA S96 014 S ' Dr. Chen Ning Yang Professor Murray Gell-Mann ^ Professor Aage Bohr The Institute for Department of Physics Niels Bohr Institutet Theoretical Physics California Institute of Technology Blegdamsvej 17 State University of New York PASADENA, CA91125 DK-2100 KOPENHAMN 0 STONY BROOK, NY 11794 USA D anni ark USA 595 600 613 Professor Owen Chamberlain Professor Louis Neel ' Professor Ben Mottelson 6068 Margarldo Drive Membre de rinstitute Nordita OAKLAND, CA 946 IS 15 Rue Marcel-Allegot Blegdamsvej 17 USA F-92190 MEUDON-BELLEVUE DK-2100 KOPENHAMN 0 Frankrike D an m ar k 599 615 Professor Donald A. -
Final Programme 12Th JVMS.Pdf
12th John Vane Memorial Symposium on Prostacyclin Science and Pulmonary Vascular Disease 17-18 March 2017 Foreword by Sir John Vane, FRS, Nobel Laureate Professor Chris Thiemermann, FMedSci by Rod Flower, FRS Dear Friends and Colleagues, Sir John Vane was one of the pre-eminent pharmacologists of the I am delighted to welcome you to the 12th John Vane Memorial twentieth century and, during a career spanning over 50 years, Symposium on Prostacyclin Science and Pulmonary Vascular made enormous contributions to the pharmacotherapy of Disease which has been made possible thanks to the valued hypertension and inflammation. support of United Therapeutics who have once again provided John was born in Worcestershire and educated at King Edward us with an unrestricted educational grant. VI School, Birmingham. His first degree (1946) was a B.Sc. in The John Vane Memorial Symposia Series has become an Chemistry at the University of Birmingham but, as he later important fixture on the Pulmonary Arterial Hypertension (PAH) explained to his tutor, he did not want to pursue chemistry as a community’s busy calendar and provides participants with a career because the subject did not excite him. By chance, he valuable opportunity to learn about the very latest clinical and was offered training as a pharmacologist under the tutelage of scientific developments in PAH from leading international experts Professor J. Harold Burn in Oxford where he really found his working in this area. métier. After obtaining his Ph.D. in 1953 John spent two years in the Department of Pharmacology at Yale University with the This year’s scientific programme includes a wealth of important (then) chairman Dr. -
Webinar Series
ISCaM2020 - 7th Annual Meeting – Webinar series Systemic Metabolism and Cancer The Francis Crick Institute, October-November 2020, in association with the Consortium for Mitochondrial Research, University College London Scientific committee: Dimitrios Anastasiou, Katiuscia Bianchi, Gyorgy Szabadkai, Mariia Yuneva _________________________________________________________________________ Zoom (same for all sessions): https://crick.zoom.us/j/63151976897?pwd=ejNSV0dBdFF5V0J6SHF5STVRa3Y3dz09 Passcode: 680444 Webinar ID: 631 5197 6897 Systemic Metabolism and Cancer 1: Cancer Therapy and Diet 20 October, 2020, 4pm Keynote: Karen Vousden, The Francis Crick Institute, London, UK Valter D Longo, IFOM, FIRC Institute of Molecular Oncology, Milano, Italy, Longevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA. Jason W Locasale, Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. Almut Schulze, Division of Tumor Metabolism and Microenvironment, German Cancer Research Center, Heidelberg, Germany Systemic Metabolism and Cancer 2: The Tumour Microenvironment 27 October, 2020, 4pm Jean-Ehrland Ricci, Metabolism and Lymphoma : from basic to translational research Université Côte d'Azur, INSERM U1065, Nice, France Katiuscia Bianchi, Barts Cancer Institute, John Vane Science Centre, Queen Mary University of London, London, UK Kathrin Renner, Regensburg Center for Interventional Immunology (RCI), Regensburg, Germany -
Jewish Organizations RG-48.017: 2009.217 United States Holocaust Memorial Museum 100 Raoul Wallenberg Place SW Washington, DC 20024-2126 Tel
Židovské organizace (425): Jewish Organizations RG-48.017: 2009.217 United States Holocaust Memorial Museum 100 Raoul Wallenberg Place SW Washington, DC 20024-2126 Tel. (202) 479-9717 e-mail: [email protected] I. Supplementary Materials: Register of Names The following register of names is provided courtesy of the JDC Archives (https://archives.jdc.org/). Any references to restrictions or services in the document below refer only to the JDC Archives. For assistance in accessing this collection at the United States Holocaust Memorial Museum, please contact [email protected]. Index to the Case Files of the AJDC Emigration Service, Prague Office, 1945-1950 This index provides the names of clients served by the AJDC Emigration Service in Czechoslovakia in the years immediately following the end of World War II. It represents the contents of boxes 1-191 of the AJDC Prague Office Collection, held at the Institute for the Study of Totalitarian Regimes, Prague. The JDC Archives received a set of digital files of this collection in 2019 via the U.S. Holocaust Memorial Museum with the Institute’s agreement. The index was created thanks to a group of JDC Archives Indexing Project volunteers and staff. Users of this index are encouraged to try alternate spellings for names (e.g., Ackerman/Ackermann; Lowy/Loewy; Schwartz/Schwarz/Swarc/Swarz). Note that women’s surnames may or may not include the suffix -ova. The “find” feature (PC: ctrl+F; Mac: command+F) may be used to search for names listed in the Additional Name(s) column that may be separated from their alphabetical order. -
The Impact of NMR and MRI
WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _____________________________________________________________________________ MAKING THE HUMAN BODY TRANSPARENT: THE IMPACT OF NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING _________________________________________________ RESEARCH IN GENERAL PRACTICE __________________________________ DRUGS IN PSYCHIATRIC PRACTICE ______________________ THE MRC COMMON COLD UNIT ____________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY D A CHRISTIE L A REYNOLDS Volume Two – September 1998 ©The Trustee of the Wellcome Trust, London, 1998 First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 186983 539 1 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as : Tansey E M, Christie D A, Reynolds L A. (eds) (1998) Wellcome Witnesses to Twentieth Century Medicine, vol. 2. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Professor Sir Godfrey Hounsfield, speaking (NMR) Professor Robert Steiner, Professor Sir Martin Wood, Professor Sir Rex Richards (NMR) Dr Alan Broadhurst, Dr David Healy (Psy) Dr James Lovelock, Mrs Betty Porterfield (CCU) Professor Alec Jenner (Psy) Professor David Hannay (GPs) Dr Donna Chaproniere (CCU) Professor Merton Sandler (Psy) Professor George Radda (NMR) Mr Keith (Tom) Thompson (CCU) Back cover photographs, L to R, from the top: Professor Hannah Steinberg, Professor -
Journal of the Endocrine Society
Journal of the Endocrine Society Predicted Benign and Synonymous variants in CYP11A1 Causes Primary Adrenal Insufficiency through Missplicing --Manuscript Draft-- Manuscript Number: js.2018-00130R1 Article Type: Research Article Full Title: Predicted Benign and Synonymous variants in CYP11A1 Causes Primary Adrenal Insufficiency through Missplicing Order of Authors: Avinaash Maharaj Federica Buonocore Eirini Meimaridou Gerard Ruiz-Babot Leonardo Guasti Hwei-Ming Peng Cameron Capper Neikelyn Burgos-Tirado Rathi Prasad Claire Hughes Ashwini Maudhoo Elizabeth Crowne Timothy Cheetham Caroline Brain Jenifer Suntharalingham Niccolo Striglioni Bilgin Yuksel Fatih Gurbuz Sanjay Gupta Robert Lindsay Robert Couch Helen Spoudeas Tulay Guran Stephanie Johnson Dallas Fowler Louise Conwell Aideen Mcinerney-Leo Delphine Drui Bertrand Cariou Juan Lopez-Siguero Mark Harris Emma Duncan Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation Richard Auchus Peter Hindmarsh Malcolm Donaldson John Achermann Louise A Metherell, Bsc, PhD Author Comments: The authors reports no conflicts of interest in this work. Abstract: Primary adrenal insufficiency (PAI) is a potentially life-threatening condition that can present with non-specific features and can be difficult to diagnose. Here, we undertook next-generation sequencing in a cohort of children and young adults with PAI of unknown etiology from around the world and identified a heterozygous missense variant (rs6161, c.940G>A, p.Glu314Lys) in CYP11A1 in 19 individuals from 13 different families (allele frequency within undiagnosed PAI in our cohort 0.102 vs 0.0026 in gnomAD, p<0.0001). Seventeen individuals harbored a second heterozygous rare disruptive variant in CYP11A1 and two patients had very rare synonymous changes in trans (c.990G>A, Thr330=; c.1173C>T, Ser391=). -
Surname First Name Categorisation Abadin Jose Luis Silver Abbelen
2018 DRIVERS' CATEGORISATION LIST Updated on 09/07/2018 Drivers in red : revised categorisation Drivers in blue : new categorisation Surname First name Categorisation Abadin Jose Luis Silver Abbelen Klaus Bronze Abbott Hunter Silver Abbott James Silver Abe Kenji Bronze Abelli Julien Silver Abergel Gabriele Bronze Abkhazava Shota Bronze Abra Richard Silver Abreu Attila Gold Abril Vincent Gold Abt Christian Silver Abt Daniel Gold Accary Thomas Silver Acosta Hinojosa Julio Sebastian Silver Adam Jonathan Platinum Adams Rudi Bronze Adorf Dirk Silver Aeberhard Juerg Silver Afanasiev Sergei Silver Agostini Riccardo Gold Aguas Rui Gold Ahlin-Kottulinsky Mikaela Silver Ahrabian Darius Bronze Ajlani Karim Bronze Akata Emin Bronze Aksenov Stanislas Silver Al Faisal Abdulaziz Silver Al Harthy Ahmad Silver Al Masaood Humaid Bronze Al Qubaisi Khaled Bronze Al-Azhari Karim Bronze Alberico Neil Silver Albers Christijan Platinum Albert Michael Silver Albuquerque Filipe Platinum Alder Brian Silver Aleshin Mikhail Platinum Alesi Giuliano Silver Alessi Diego Silver Alexander Iradj Silver Alfaisal Saud Bronze Alguersuari Jaime Platinum Allegretta Vincent Silver Alleman Cyndie Silver Allemann Daniel Bronze Allen James Silver Allgàuer Egon Bronze Allison Austin Bronze Allmendinger AJ Gold Allos Manhal Bronze Almehairi Saeed Silver Almond Michael Silver Almudhaf Khaled Bronze Alon Robert Silver Alonso Fernando Platinum Altenburg Jeff Bronze Altevogt Peter Bronze Al-Thani Abdulrahman Silver Altoè Giacomo Silver Aluko Kolawole Bronze Alvarez Juan Cruz Silver Alzen -
Wellcome Witnesses to Twentieth Century Medicine
WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _______________________________________________________________ TECHNOLOGY TRANSFER IN BRITAIN: THE CASE OF MONOCLONAL ANTIBODIES ______________________________________________ SELF AND NON-SELF: A HISTORY OF AUTOIMMUNITY ______________________ ENDOGENOUS OPIATES _____________________________________ THE COMMITTEE ON SAFETY OF DRUGS __________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY P P CATTERALL D A CHRISTIE S V WILLHOFT L A REYNOLDS Volume One – April 1997 CONTENTS WHAT IS A WITNESS SEMINAR? i E M TANSEY TECHNOLOGY TRANSFER IN BRITAIN: THE CASE OF MONOCLONAL ANTIBODIES EDITORS: E M TANSEY AND P P CATTERALL TRANSCRIPT 1 INDEX 33 SELF AND NON-SELF: A HISTORY OF AUTOIMMUNITY EDITORS: E M TANSEY, S V WILLHOFT AND D A CHRISTIE TRANSCRIPT 35 INDEX 65 ENDOGENOUS OPIATES EDITORS: E M TANSEY AND D A CHRISTIE TRANSCRIPT 67 INDEX 100 THE COMMITTEE ON SAFETY OF DRUGS EDITORS: E M TANSEY AND L A REYNOLDS TRANSCRIPT 103 INDEX 133 WHAT IS A WITNESS SEMINAR? Advances in medical science and medical practice throughout the twentieth century, and especially after the Second World War, have proceeded at such a pace, and with such an intensity, that they provide new and genuine challenges to historians. Scientists and clinicians themselves frequently bemoan the rate at which published material proliferates in their disciplines, and the near impossibility of ‘keeping up with the literature’. Pity, then, the poor historian, trying to make sense of this mass of published data, scouring archives for unpublished accounts and illuminating details, and attempting throughout to comprehend, contextualize, reconstruct and convey to others the stories of the recent past and their significance. The extensive published record of modern medicine and medical science raises particular problems for historians: it is often presented in a piecemeal but formal fashion, sometimes seemingly designed to conceal rather than reveal the processes by which scientific medicine is conducted. -
Growth of Malignant Extracranial Tumors Alters Micrornaome in the Prefrontal Cortex of Tumorgraft Mice
www.impactjournals.com/oncotarget/ Oncotarget, 2017, Vol. 8, (No.51), pp: 88276-88293 Research Paper: Gerotarget (Focus on Aging) Growth of malignant extracranial tumors alters microRNAome in the prefrontal cortex of TumorGraft mice Anna Kovalchuk1,4, Yaroslav Ilnytskyy2, Rocio Rodriguez-Juarez2, Amanda Katz3, David Sidransky3, Bryan Kolb1 and Olga Kovalchuk2 1 Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada 2 Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada 3 Department of Oncology, Champions Oncology, Baltimore, MD, USA 4 Leaders in Medicine Program, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Correspondence to: Bryan Kolb, email: [email protected] Correspondence to:Olga Kovalchuk, email: [email protected] Keywords: chemo brain, tumor brain, epigenetics, microRNA, Gerotarget Received: April 04, 2017 Accepted: April 27, 2017 Published: August 03, 2017 Copyright: Kovalchuk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT A wide array of central nervous system complications, neurological deficits, and cognitive impairments occur and persist as a result of systemic cancer and cancer treatments. This condition is known as chemo brain and it affects over half of cancer survivors. Recent studies reported that cognitive impairments manifest before chemotherapy and are much broader than chemo brain alone, thereby adding in tumor brain as a component. The molecular mechanisms of chemo brain are under- investigated, and the mechanisms of tumor brain have not been analyzed at all. -
Physiologynews
PHYSIOLOGYNEWS spring 2005 | number 58 IUPS 2005 Images of the Bristol, Nottingham, Oxford and KCL Meetings Also featuring: Living history – the case of the misbehaving circuit 50 years of caveolae Obesity – why all the noise? From tadpole to frog: a tale of two networks The Nobel Prize A publication of the Physiological Society King’s College London Images from and around King’s College London, venue for the Physiological Society Meeting 17-20 December, 2004 (photos by Prem Kumar) More images from the KCL Meeting appear on the inside back cover PHYSIOLOGYNEWS Editorial 3 IUPS 2005 4 Images of KCL Prem Kumar, David Eisner ifc, ibc The Society’s dog. ‘Rudolf Magnus gave Oxford Focused Meeting Denis Noble 5 me to Charles Sherrington, who gave me Nottingham Focused Meeting Paul Greenhaff 6 to Henry Dale, who gave me to the Bristol Focused Meeting Sergey Kasparov, Julian Paton 7 Physiological Society in October 1942’ ‘The Senses’ Karl Gegenfurtner 8 Living History The case of the misbehaving circuit Stanley Salmons 9 Published quarterly by the Physiological Society A summer in the life of ... Giovanni Mann 11 Contributions and Queries Executive Editor Features Linda Rimmer The Nobel Prize Tim Jacob 12 The Physiological Society 50 years of caveolae - a round-up Michael Taggart 13 Publications Office Obesity - why all the noise? Paul Trayhurn 15 Building 4A, The Michael Young Centre Metamorphosis from tadpole to frog: a tale of two networks Denis Purbeck Road Combes, Simon Merrywest, John Simmers, Keith Sillar 17 Cambridge CB2 2HP Impact of