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Hypertrophic Olivary Degeneration Secondary to Traumatic Brain Injury: a Unique Form of Trans-Synaptic Degeneration Raman Mehrzad,1 Michael G Ho2

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Hypertrophic Olivary Degeneration Secondary to Traumatic Brain Injury: a Unique Form of Trans-Synaptic Degeneration Raman Mehrzad,1 Michael G Ho2 … Images in BMJ Case Reports: first published as 10.1136/bcr-2015-210334 on 2 July 2015. Downloaded from Hypertrophic olivary degeneration secondary to traumatic brain injury: a unique form of trans-synaptic degeneration Raman Mehrzad,1 Michael G Ho2 1Department of Medicine, DESCRIPTION haemorrhagic left superior cerebellar peduncle, all Steward Carney Hospital, Tufts A 33-year-old man with a history of traumatic brain consistent with his prior TBI. Moreover, the right University School of Medicine, Boston, Massachusetts, USA injury (TBI) from a few years prior, secondary to a inferior olivary nucleus was enlarged, which is 2Department of Neurology, high-speed motor vehicle accident, presented with exemplified in unilateral right hypertrophic olivary Steward Carney Hospital, Tufts worsening right-sided motor function. Brain MRI degeneration (HOD), likely secondary to the haem- University School of Medicine, showed diffuse axonal injury, punctuate microbleed- orrhagic lesion within the left superior cerebellar Boston, Massachusetts, USA ings, asymmetric Wallerian degeneration along the peduncle, causing secondary degeneration of the fi – Correspondence to left corticospinal tract in the brainstem and contralateral corticospinal tracts ( gures 1 6). Dr Raman Mehrzad, [email protected] Accepted 11 June 2015 http://casereports.bmj.com/ fl Figure 3 Brain axial gradient echo MRI showing Figure 1 Brain axial uid-attenuated inversion recovery haemosiderin products in the left superior cerebellar MRI showing hypertrophy of the right inferior olivary peduncle. nucleus. on 25 September 2021 by guest. Protected copyright. To cite: Mehrzad R, Ho MG. BMJ Case Rep Published online: [please include Day Month Year] Figure 2 Brain axial T2 MRI showing increased T2 Figure 4 Brain axial gradient echo MRI showing doi:10.1136/bcr-2015- signal change and hypertrophy of the right inferior evidence of haemosiderin products in the left>right 210334 olivary nucleus. midbrain, cerebral peduncles and temporal lobes. Mehrzad R, et al. BMJ Case Rep 2015. doi:10.1136/bcr-2015-210334 1 … Images in BMJ Case Reports: first published as 10.1136/bcr-2015-210334 on 2 July 2015. Downloaded from HOD is a very rare form of trans-synaptic degeneration that occurs over a long period of time when a lesion interrupts the triangle of Guillain-Mollaret.1 Damage to either the anterior spinocerebellar tracts or cerebellar efferences, which mainly run from the dentate nucleus via the superior cerebellar peduncle to the red nucleus and thalamus (dentatorubral tract), may explain our patient’s marked cerebellar syndrome. The dentatorubral tract constitutes one component of the triangle of Guillain-Mollaret, which is a functional neuronal network arranged in a feedback loop encompassing the cerebellum including the dentate nucleus, red nucleus and the inferior olivary nucleus. Fibres run from the dentate nucleus via the den- tatorubral tract within the superior cerebellar peduncle to the contralateral red nucleus. Fibres from the red nucleus project to the inferior olive via the central tegmental tract, and from there, olivocerebellar fibres run via the inferior cerebellar peduncle to the contralateral cerebellar cortex, which projects to the dentate nucleus.2 Figure 5 Brain axial gradient echo MRI sequence showing severe Learning points microhaemorrhages throughout the body of the corpus callosum. ▸ Hypertrophic olivary degeneration is a very rare form of trans-synaptic degeneration that occurs over a long period of time when a lesion interrupts the triangle of Guillain-Mollaret. ▸ Haemorrhagic lesion within the left superior cerebellar peduncle causes secondary degeneration of the contralateral corticospinal tracts, which causes this unique finding. http://casereports.bmj.com/ Competing interests None declared. Patient consent Obtained. Provenance and peer review Not commissioned; externally peer reviewed. REFERENCES 1 Guillain G, Mollaret P. Deux cas de myoclonies synchrones et rhythmes velopharyngo-laryngooculo- diaphragmatiques. Rev Neurol 1931;2: – 545 66. on 25 September 2021 by guest. Protected copyright. 2 Goto N, Kaneko M. Olivary enlargement: chronological and morphometric analyses. Figure 6 Brain axial gradient echo MRI showing haemosiderin Acta Neuropathol – products in the cortical/subcortical regions of bilateral frontal and 1981;54:275 82. parietal lobes. Copyright 2015 BMJ Publishing Group. All rights reserved. For permission to reuse any of this content visit http://group.bmj.com/group/rights-licensing/permissions. BMJ Case Report Fellows may re-use this article for personal use and teaching without any further permission. Become a Fellow of BMJ Case Reports today and you can: ▸ Submit as many cases as you like ▸ Enjoy fast sympathetic peer review and rapid publication of accepted articles ▸ Access all the published articles ▸ Re-use any of the published material for personal use and teaching without further permission For information on Institutional Fellowships contact [email protected] Visit casereports.bmj.com for more articles like this and to become a Fellow 2 Mehrzad R, et al. BMJ Case Rep 2015. doi:10.1136/bcr-2015-210334.
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