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ISEV2018 I SEV20 18 FINALABSTRA PROGRAMCT BOOK ANNUALP a lau deME C o ng re s sos de BETING arce lona - Fira M o nt juic ANNUALMEETING ANNUALMEETING 2-6 May Barcelona, Spain2-6 2-6 Annual Meeting — ISEV2018 | Barcelona, Spain | 2–6 May 2018 1 1 Table of Contents Letter from the ISEV President 3 Letter from the ISEV IOC Chair 4 Executive Board and Board of Directors 5 International Organizing Committee 6 Palau de Congressos Barcelona – Fira Montjuic Floor Plan 7 General Information 9 Plenary Speakers 11 Program Information 15 Satellite EVents 35 Abstract Directory 38 Sponsor Directory 54 Annual Meeting — ISEV2018 | Barcelona, Spain | 2–6 May 2018 2 Welcome from ISEV President Dear Colleagues, On behalf of the International Society for Extracellular Vesicles (ISEV) Board of Directors and the International Organising Committee (IOC), it is a pleasure to welcome you to ISEV2018. This year, ISEV has teamed up with GEIVEX (Spanish Society for Innovation and Investigation in Extracellular Vesicles, www. geivex.org) to organize ISEV2018. The ISEV2018 IOC, composed of ISEV and GEIVEX board members, had worked hard to prepare an interesting and dynamic program that includes educational sessions, along with the latest advances of the field - representing both fundamental and clinical aspects. In 2018, we will host a record number of attendees at the annual ISEV meeting and this reflects the growing recognition of the field and the numbers of researchers now working on extracellular vesicles. ISEV2018 begins with the Education Day, covering two tracks in “Biology and Technology” and “EVs in Health and Disease”. The main meeting features again this year the ‘Meet the Experts’ and ‘Experts Workshops’ sessions in addition to the national societies session – all aimed at increasing networking amongst our international community. There are satellite sessions covering “Emerging Trends in HIV, NeuroAIDS, Drug Abuse and EVs”, an “exRNA ERCC Workshop”, and a meeting of the ISEV-ISAC-ISTH EV flow cytometry workgroup. This year we introduce sessions including an Early Career Development Session on Academia and Industry in the field of EVs as well as a “Meet the Editors” session featuring presentations from journal editors relevant to the EV field. I would like to thank the members of the IOC, led by Juan M. Falcón-Pérez, for their efforts in making ISEV2018 possible. Also, thanks to the ISEV Board of Directors for their continued commitments to growing and supporting ISEV and serving the community of EV researchers. On behalf of ISEV, we also acknowledge and thank our corporate sponsors who provide essential support for the meeting. Don’t forget to attend the not-to-be-missed Networking Event on Saturday 5th May at 20:15 – a great opportunity to network and socialize with attendees of the meeting. I hope you enjoy all that ISEV2018 has to offer and wish you all the best with your EV research that follows! Regards, Andy Hill, PhD President, ISEV Annual Meeting — ISEV2018 | Barcelona, Spain | 2–6 May 2018 3 Welcome from the International Organizing Committee Chair Dear Colleagues: On behalf of the International Organizing Committee, it is with great pleasure that I welcome you to the the seventh Annual Meeting of the International Society for Extracellular Vesicles. It has been an honor to organize this meeting where scientists from around the globe share the latest knowledge on extracellular vesicles that represent a new paradigm both in cell biology and medicine. They are considered to offer unprecedented opportunities for future applications from new generation diagnostic or prognostic biomarkers to therapeutic applications. The International Society for Extracellular Vesicles (ISEV) was founded in 2011, and as the authoritative international community for extracellular vesicle research, it focuses on all aspects of extracellular vesicle investigations. More than 1000 delegates will attend ISEV2018 presenting over 700 scientific presentations. The annual meeting will feature speakers covering novel and stimulating scientific areas including “Autophagy, Metabolism, Aging”, “Advances in Exosome Biology”, “Environment, Diet & Health”, “Neglected Diseases” and “Tissue Architecture”. A dedicated scientific program with 30 symposium sessions will cover all aspects of EV research from basic research, technological development and clinic applications. The program will be completed by the Meet- the-Expert sessions on “EV-Biobanks”, “EV-Regulatory aspects”, “EV-RNA”, “EV-Biomarkers”, “EV-Immunology”, “EV-Neglected diseases”, “EV-Leukemia (Josep Carreras Foundation)”, “EV-in vivo Imaging”, and the “EV-blood roadmap”. In addition, there will be satellite sessions on Flow Cytometry (joint session with ISAC and ISTH), EV- HIV and RNA-ERCC, as well as, the meeting with the EV-related National Societies. This year also offers sessions to meet the editors of journals, and have the opportunity to listen tips from young EV-successful researchers on academic an industry tracks during the “Young EV Career Development” session. During the congress, ISEV will introduce new developments in EV-based 3D animation and outreach strategies that ISEV is supporting. Be sure to attend the Opening Ceremony and enjoy a performance by tenor Sergi Gimenez Carreras. The networking event on Saturday evening will be held in Cupula at the Arenas de Barcelona with different entertainment options embedded in the cosmopolitan Barcelona´s environment. ISEV is committed to creating a most memorable scientific congress. Through your participation, interest, and support, you will certainly contribute to the success of the meeting and the advancement of novel extracellular vesicle studies. Again, welcome to Barcelona! On behalf of the International Organizing Committee, Juan Falcón-Pérez Chair, International Organizing Committee Annual Meeting — ISEV2018 | Barcelona, Spain | 2–6 May 2018 4 About the International Society for Extracellular Vesicles ISEV is a global society of researchers and scientists studying exosomes and microvesicles. With over 1,000 members, ISEV is the leading advocate and guide of extracellular vesicle research with a mission of advancing extracellular vesicle research globally. ISEV Executive Board and Board of Directors 2016-2018 President Executive Chair, Communications Carolina Soekmadji Andrew Hill Dolores Di Vizio Australia Australia United States Secretary General Past President Hidetoshi Tahara Asia Pacific Kenneth Witwer Jan Lötvall United States Sweden Treasurer Chair International Organizing Committee Ana Claudia Torrecilhas Brazil Chris Gardiner United Kingdom Juan Falcón-Pérez Spain Executive Chair, Science/Meetings Alissa Weaver Members at Large United States Marca Wauben The Netherlands Rienk Nieuwland Executive Chair, Education Hubert Yin The Netherlands China/United States Edit Buzas Hungary Susmita Sahoo Lei Zheng United States China Annual Meeting — ISEV2018 | Barcelona, Spain | 2–6 May 2018 5 2018 International Organizing Committee Members Juan Falcón-Pérez, PhD Isabel Guerrero Hidetoshi Tahara IOC Chair UAM/CBM-SO Hiroshima University CIC bioGUNE Madrid, Spain Hiroshima, Japan Bizkaia, Spain Andrew Hill Marca Wauben Hernando A. del Portillo ISEV President Utrecht University GEIVEX President La Trobe University Utrecht, The Netherlands ICREA at ISGlobal and IGTP Melbourne Australia Barcelona, Spain Kenneth Witwer Antonio Marcilla Johns Hopkins University Francesc Borrás Universitat de València Baltimore, MD USA "Germans Trias i Pujol" Research Institute Valencia, Spain (IGTP),Can Ruti Campus Barcelona, Spain María Yáñez-Mó Héctor Peinado UAM/CBM-SO Spanish National Cancer Madrid, Spain Edit Buzas Research Center – CNIO Semmelweis University Madrid, Spain Budapest, Hungary Hubert Yin Colorado University Susmita Sahoo Boulder, Colorado Dolores DiVizio Mount Sinai School of Medicine Cedars-Sinai Medical Center New York, NY USA Los Angeles, CA USA Annual Meeting — ISEV2018 | Barcelona, Spain | 2–6 May 2018 6 Hall 5 Montjuïc ROOM 9 41 sqm LEVEL 4 OFFICES 16 sqm each (X2) Auditorium ROOM 7 ROOM 5 1362 sqm 277 sqm Palau deHall Congressos 5 ROOM Barcelona 8 –Hall Fira 5 Montjuic 150 sqm ROOM 3 Floor PlanLEVEL 3 Montjuïc ROOM 6 183 sqm Halls and open areas ROOM 9 310 sqm Enclosed rooms ROOMS 1 and 2 41 sqm LEVEL 4 39 sqm each Elevators OFFICES Restrooms 16 sqm each (X2) Auditorium ROOM 7 ROOM 5 Catering outlet ROOM 4 Hall 5 1362 sqm 277 sqm Desk/ cloakroom 108 sqm Hall 5 ROOM 8 LEVEL 2 Montjuïc 150 sqm ROOM 3 VIP AREA ROOM 9 Public Access LEVEL 3 183 sqm 341 sqm 41 sqm ROOM 6 Halls and open areas 528 528 sqm LEVEL 4 310 sqm height 5,69m ROOMS 1 and 2 Enclosed rooms OFFICES 39 sqm each Elevators 16 sqm each (X2) Auditorium ROOM 7 Restrooms ROOM 5 Public Access 1362 sqm LEVEL 1 Catering outlet 277 sqm ROOM 4 Hall 5 ROOM 8 street level Desk/ cloakroom 108 sqm 150 sqm 2,28 sqm ROOM 3 LEVELheight 2 5,36m LEVEL 3 1,95 sqm ROOM 6 183 sqm VIP AREA height 2,0m Public Access Halls and open areas 310 sqm 341 sqm Enclosed rooms ROOMS 1 and 2 528 528 sqm height 5,69m 39 sqm each ROOMS 11 and12 Elevators 124 and 138 sqm Restrooms LEVEL 0 Public Access Catering outlet ROOM 4 LEVEL 1 Desk/ cloakroom 108 sqm street level 2,28 sqm LEVEL 2 height 5,36m 1,95 sqm VIP AREA Public Access height 2,0m 341 sqm 528 528 sqm height 5,69m ROOMS 11 and12 124 and 138 sqm Public Access LEVEL 0 LEVEL 1 street level 2,28 sqm height 5,36m 1,95 sqm height 2,0m ROOMS 11 and12 124 and 138 sqm LEVEL 0 Annual Meeting — ISEV2018 | Barcelona, Spain | 2–6 May 2018 7 Acknowledgements ISEV gratefully acknowledges the support of the 2018 Annual Conference from our Sponsors: PLATINUM SILVER BRONZE LANYARD SPONSOR NOTEPAD SPONSOR EXHIBITORS Annual Meeting — ISEV2018 | Barcelona, Spain | 2–6 May 2018 8 General Information Abstracts Exhibits Abstracts for plenary and parallel sessions are Educational and informational exhibits will be included in the Abstract Book, which is available available for viewing during the Annual Meeting for download from the conference website: and representatives will be on hand to answer http://www.isev.org/page/ISEV2018homepage.