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Estimation of Hydrolysis Rate Constants of Carboxylic Acid Ester and Phosphate Ester Compounds in Aqueous Systems from Molecular Structure by SPARC
Estimation of Hydrolysis Rate Constants of Carboxylic Acid Ester and Phosphate Ester Compounds in Aqueous Systems from Molecular Structure by SPARC R E S E A R C H A N D D E V E L O P M E N T EPA/600/R-06/105 September 2006 Estimation of Hydrolysis Rate Constants of Carboxylic Acid Ester and Phosphate Ester Compounds in Aqueous Systems from Molecular Structure by SPARC By S. H. Hilal Ecosystems Research Division National Exposure Research Laboratory Athens, Georgia U.S. Environmental Protection Agency Office of Research and Development Washington, DC 20460 NOTICE The information in this document has been funded by the United States Environmental Protection Agency. It has been subjected to the Agency's peer and administrative review, and has been approved for publication. Mention of trade names of commercial products does not constitute endorsement or recommendation for use. ii ABSTRACT SPARC (SPARC Performs Automated Reasoning in Chemistry) chemical reactivity models were extended to calculate hydrolysis rate constants for carboxylic acid ester and phosphate ester compounds in aqueous non- aqueous and systems strictly from molecular structure. The energy differences between the initial state and the transition state for a molecule of interest are factored into internal and external mechanistic perturbation components. The internal perturbations quantify the interactions of the appended perturber (P) with the reaction center (C). These internal perturbations are factored into SPARC’s mechanistic components of electrostatic and resonance effects. External perturbations quantify the solute-solvent interactions (solvation energy) and are factored into H-bonding, field stabilization and steric effects. These models have been tested using 1471 reliable measured base, acid and general base-catalyzed carboxylic acid ester hydrolysis rate constants in water and in mixed solvent systems at different temperatures. -
Attenuation of Pathogenic Immune Responses During Infection with Human and Simian Immunodeficiency Virus (HIV/SIV) by the Tetracycline Derivative Minocycline
Attenuation of Pathogenic Immune Responses during Infection with Human and Simian Immunodeficiency Virus (HIV/SIV) by the Tetracycline Derivative Minocycline Julia L. Drewes1, Gregory L. Szeto1¤, Elizabeth L. Engle1, Zhaohao Liao1, Gene M. Shearer2,M. Christine Zink1*, David R. Graham1,3* 1 Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Johns Hopkins Bayview Proteomics Center, Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine Bayview Campus, Baltimore, Maryland, United States of America Abstract HIV immune pathogenesis is postulated to involve two major mechanisms: 1) chronic innate immune responses that drive T cell activation and apoptosis and 2) induction of immune regulators that suppress T cell function and proliferation. Both arms are elevated chronically in lymphoid tissues of non-natural hosts, which ultimately develop AIDS. However, these mechanisms are not elevated chronically in natural hosts of SIV infection that avert immune pathogenesis despite similarly high viral loads. In this study we investigated whether minocycline could modulate these pathogenic antiviral responses in non-natural hosts of HIV and SIV. We found that minocycline attenuated in vitro induction of type I interferon (IFN) and the IFN-stimulated genes indoleamine 2,3-dioxygenase (IDO1) and TNF-related apoptosis inducing ligand (TRAIL) in human plasmacytoid dendritic cells and PBMCs exposed to aldrithiol-2 inactivated HIV or infectious influenza virus. Activation- induced TRAIL and expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4) in isolated CD4+ T cells were also reduced by minocycline. -
GREEN BOOK 4 Alkyl Benzoates CIR EXPERT PANEL MEETING
GREEN BOOK 4 Alkyl Benzoates CIR EXPERT PANEL MEETING AUGUST 30-31, 2010 July 30, 2010 MEMORANDUM To: CIR Expert Panel and Liaisons From: Lillian C. Becker, M.S. Scientific Analyst and Writer Subject: Draft Report for C12-15 Alkyl Benzoate and related Alkyl Benzoates The Cosmetic Ingredient Review (CIR) announced the Scientific Literature Review (SLR) for alkyl benzoates in June, 2010. C12-15 alkyl benzoate is the lead ingredient of this safety assessment. Related alkyl benzoate ingredients are included. CIR has been informed that a comprehensive dossier on the C12-15 alkyl benzoates being prepared for the European REACH program will be completed and provided to CIR in late September or early October. The Panel should review the Draft Report and decide: 1) if it is reasonable to include the other listed ingredients with C12-15 alkyl benzoate in this report and 2) whether any additional data are needed in order to reach a safety conclusion for C12-15 alkyl benzoates and the related ingredients. If no additional data are required, then the Panel may issue a Tentative Report. Alternatively, the Panel may choose to table the report to await the receipt of the dossier mentioned above. CIR Panel Book Page 1 CIR Panel Book Page 2 History of Alkyl Benzoates June, 2010 – SLR issued. August, 2010 - CIR Panel Book Page 3 Search Strategy for Benzoates EXPORATORY SEARCH: PUBMED: “alkyl benzoate” – 7 hits, 1 useful; CAS No. – 0 hits. Internet (Dogpile) – “alkyl benzoate” ‐ 1 MSDS FULL SEARCH: PUBMED: “lauryl alcohol” – 53 hits, 6 ordered. Learned that Valerie was doing this ingredient. -
University of Groningen Mechanics of Extracellular Vesicles
University of Groningen Mechanics of extracellular vesicles derived from malaria parasiteinfected Red Blood Cells Sorkin, Raya; Vorselen, Daan; Ofir-Birin, Yifat; Roos, Wouter H.; MacKintosh, Fred C.; Regev-Rudzki, Neta; Wuite, Gijs J. L. Published in: Journal of Extracellular Vesicles DOI: 10.3402/jev.v5.31552 IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Sorkin, R., Vorselen, D., Ofir-Birin, Y., Roos, W. H., MacKintosh, F. C., Regev-Rudzki, N., & Wuite, G. J. L. (2016). Mechanics of extracellular vesicles derived from malaria parasiteinfected Red Blood Cells. Journal of Extracellular Vesicles, 5, 86. https://doi.org/10.3402/jev.v5.31552 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 12-11-2019 -
Human Perivascular Stem Cell-Derived Extracellular Vesicles Mediate Bone
RESEARCH ARTICLE Human perivascular stem cell-derived extracellular vesicles mediate bone repair Jiajia Xu1, Yiyun Wang1, Ching-Yun Hsu1, Yongxing Gao1, Carolyn Ann Meyers1, Leslie Chang1, Leititia Zhang1,2, Kristen Broderick3, Catherine Ding4, Bruno Peault4,5,6, Kenneth Witwer7,8, Aaron Watkins James1* 1Department of Pathology, Johns Hopkins University, Baltimore, United States; 2Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China; 3Department of Surgery, Johns Hopkins University, Baltimore, United States; 4Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, UCLA, Orthopaedic Hospital, Los Angeles, United States; 5Centre For Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; 6MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom; 7Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, United States; 8Department of Neurology, Johns Hopkins University, Baltimore, United States Abstract The vascular wall is a source of progenitor cells that are able to induce skeletal repair, primarily by paracrine mechanisms. Here, the paracrine role of extracellular vesicles (EVs) in bone healing was investigated. First, purified human perivascular stem cells (PSCs) were observed to induce mitogenic, pro-migratory, and pro-osteogenic effects on osteoprogenitor cells while in non- contact co-culture via elaboration of EVs. PSC-derived EVs shared mitogenic, pro-migratory, and pro-osteogenic properties of their parent cell. PSC-EV effects were dependent on surface- associated tetraspanins, as demonstrated by EV trypsinization, or neutralizing antibodies for CD9 or CD81. Moreover, shRNA knockdown in recipient cells demonstrated requirement for the CD9/ CD81 binding partners IGSF8 and PTGFRN for EV bioactivity. Finally, PSC-EVs stimulated bone repair, and did so via stimulation of skeletal cell proliferation, migration, and osteodifferentiation. -
Development of Chemoinformatic Tools to Enumerate Functional Groups in Molecules for Organic Aerosol Characterization G
Manuscript prepared for Atmos. Chem. Phys. with version 2015/04/24 7.83 Copernicus papers of the LATEX class copernicus.cls. Date: 1 March 2016 Technical Note: Development of chemoinformatic tools to enumerate functional groups in molecules for organic aerosol characterization G. Ruggeri1 and S. Takahama1 1ENAC/IIE Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland Correspondence to: Satoshi Takahama (satoshi.takahama@epfl.ch) Abstract. Functional groups (FGs) can be used as a reduced representation of organic aerosol composition in both ambient and environmental controlled chamber studies, as they retain a cer- tain chemical specificity. Furthermore, FG composition has been informative for source apportion- ment, and various models based on a group contribution framework have been developed to calcu- 5 late physicochemical properties of organic compounds. In this work, we provide a set of validated chemoinformatic patterns that correspond to: 1) a complete set of functional groups that can entirely describe the molecules comprised in the α-pinene and 1,3,5-trimethylbenzene MCMv3.2 oxidation schemes, 2) FGs that are measurable by Fourier transform infrared spectroscopy (FTIR), 3) groups incorporated in the SIMPOL.1 vapor pressure estimation model, and 4) bonds necessary for the cal- 10 culation of carbon oxidation state. We also provide example applications for this set of patterns. We compare available aerosol composition reported by chemical speciation measurements and FTIR for different emission sources, and calculate the FG contribution to the O:C ratio of simulated gas phase composition generated from α-pinene photooxidation (using MCMv3.2 oxidation scheme). 1 Introduction 15 Atmospheric aerosols are complex mixtures of inorganic salts, mineral dust, sea salt, black carbon, metals, organic compounds, and water (Seinfeld and Pandis, 2006). -
Door 2.0 - Comprehensive Mapping of Drosophila Melanogaster Odorant Responses
DoOR 2.0 - Comprehensive Mapping of Drosophila melanogaster Odorant Responses Daniel Münch1,* and C. Giovanni Galizia1 1Neurobiology, University of Konstanz, 78457 Konstanz, Germany *[email protected] Supplementary Figures & Tables Or47b overlap 5 Or47b overlap 3 Or47b Dweck LTK: 0.25; n: 178 LTK: 3.4; n: 218 LTK: 33.12; n: 43 0.5 0.5 0.5 0.0 0.0 0.0 DoOR response −0.5 −0.5 −0.5 odorants ab4B all ab4B geosmin LTK: −1.53; n: 182 LTK: 89.35; n: 181 0.5 0.5 0.0 0.0 DoOR response −0.5 −0.5 odorants (a) model: inv.sigmoid model: inv.asympOff model: sigmoid n = 12 n = 10 n = 16 MD = 0.093643 MD = 0.140333 MD = 0.052509 merged_data merged_data Hallem.2004.EN 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.2 0.4 0.6 0.8 1.0 0.0 0.2 0.4 0.6 0.8 1.0 0.0 0.4 0.8 Hallem.2006.EN Pelz.2005.Or47bnmr Hallem.2004.WT model: inv.linear model: inv.linear n = 44 n = 3 MD = 0.124972 MD = 0.027766 merged_data merged_data 0.0 0.5 1.0 0.0 0.5 1.0 1.5 0.0 0.2 0.4 0.6 0.8 1.0 0.0 0.4 0.8 Muench.2015.AntGC1 Dweck.2015b.WT (b) Figure S1: Related to Figure3. Merging two narrowly tuned responding units with different merge-specifications. -
Announcing the ISEV2020 Special Achievement Award Recipients
Thomas Jefferson University Jefferson Digital Commons Kimmel Cancer Center Faculty Papers Kimmel Cancer Center 10-1-2020 Announcing the ISEV2020 special achievement award recipients: Andrew Hill and Edit Buzás; and the recipient of the ISEV2020 special education award: Carolina Soekmadji. Kenneth W Witwer Lucia R Languino Alissa M Weaver Marca H Wauben Follow this and additional works at: https://jdc.jefferson.edu/kimmelccfp Part of the Oncology Commons Let us know how access to this document benefits ouy This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in Kimmel Cancer Center Faculty Papers by an authorized administrator of the Jefferson Digital Commons. For more information, please contact: [email protected]. Received: 30 July 2020 Accepted: 8 September 2020 DOI: 10.1002/jev2.12021 EDITORIAL Announcing the ISEV special achievement award recipients: AndrewHillandEditBuzás;andtherecipientoftheISEV special education award: Carolina Soekmadji The International Society for Extracellular Vesicles (ISEV) is pleased to announce two Special Achievement Awards that were presented at the virtual ISEV2020 annual meeting, 20–22 July 2020. ISEV Special Achievement Awards are given each year to one or more individuals who have made outstanding contributions to the field of extracellular vesicle (EV) research or have per- formed extraordinary service to ISEV (Witwer, Hill, & Tahara, 2019). -
Isct2021 Program
MAY 26–28 ISCT2021 VIRTUAL Orchestrating Global CGT Translation Building Consensus for the Path Forward PROGRAM MAY 26–28 ISCT2021 VIRTUAL WELCOME FROM THE ISCT PRESIDENT Dear Friends and Colleagues, a day, 3 concurrent tracks), and all of which will be available for viewing on demand for the remainder of 2021. Extra effort We ARE friends AND colleagues! Just as ISCT is a Society has been invested for enhanced virtual Networking, with a full like no other, ISCT 2021 Virtual New Orleans will continue ISCT 2021 Networking Day on May 25. During the Networking our breakthrough last year in providing a virtual platform Day, you can attend the inaugural Investigators to Investors with industry leading presentation technology that is im- (I to I) Workshop, organized by the ISCT Business Models & mersive and informative, enlightening and engaging in a Investment Commercialization Sub-Committee, which will multi-dimensional platform that reflects our Society values. bring together cell and gene therapy investors for a half-day We promote innovation in translational research. We strive educational event providing unparalleled access to cell and for excellence in everything we do. We respect and support gene therapy key opinion leaders. diversity and inclusivity. We uphold the highest ethical stan- dards. We serve our members and advocate for our Society. The anchor for your ISCT program is the six plenary ses- sions. Leading off, our President Elect Jacques Galipeau Over the past year, the world has seen great tragedy and will chair the plenary “COVID-19: Understanding the Path scientific advances to meet pandemic challenges. The field Forward for Mesenchymal Stromal Cell Therapies.” For the of cell and gene therapy continues to break new ground, Presidential Plenary, representing the Commercialization advancing medical care for patients worldwide. -
Extracellular Vesicles and Nanoerythrosomes: the Hidden Pearls of Blood Products
Academic Dissertations from The Finnish Red Cross Blood Service number 64 SAMI VALKONEN | Extracellular Vesicles and Nanoerythrosomes: The Hidden Pearls of Blood Products Blood Nanoerythrosomes: Pearls of Extracellular and Hidden The | Vesicles SAMI VALKONEN SAMI VALKONEN Extracellular Vesicles and Nanoerythrosomes: The Hidden Pearls of Blood Products ISBN 978-952-5457-48-3 (print) ISBN 978-952-5457-49-0 (pdf) ISSN 1236-0341 FRC BS: 64 http://ethesis.helsinki.fi Turku 2019 Painosalama Oy ACADEMIC DISSERTATION, NUMBER 64 Doctoral School of Health Sciences Doctoral Programme in Biomedicine Molecular and Integrative Biosciences Research Programme Faculty of Biological and Environmental Sciences University of Helsinki and Finnish Red Cross Blood Service EXTRACELLULAR VESICLES AND NANOERYTHROSOMES: THE HIDDEN PEARLS OF BLOOD PRODUCTS Sami Valkonen ACADEMIC DISSERTATION To be presented for public examination, with the permission of the Faculty of Biological and Environmental Sciences of the University of Helsinki, in Nevanlinna Auditorium of the Finnish Red Cross Blood Service, Kivihaantie 7, Helsinki, on 19th December 2019, at 12 noon. Helsinki 2019 ACADEMIC DISSERTATIONS FROM THE FINNISH RED CROSS BLOOD SERVICE, NUMBER 64 Supervisors Adjunct Professor Pia Siljander Faculty of Biological and Environmental Sciences University of Helsinki Doctor Saara Laitinen Department of Research & Development Finnish Red Cross Blood Service Thesis Committee Associate Professor Susanna Fagerholm Faculty of Biological and Environmental Sciences University of -
Downloaded From
Canonical Type I IFN Signaling in Simian Immunodeficiency Virus-Infected Macrophages Is Disrupted by Astrocyte-Secreted CCL2 This information is current as of September 27, 2021. Luna Alammar Zaritsky, Lucio Gama and Janice E. Clements J Immunol published online 9 March 2012 http://www.jimmunol.org/content/early/2012/03/09/jimmun ol.1103024 Downloaded from Why The JI? Submit online. http://www.jimmunol.org/ • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average by guest on September 27, 2021 Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2012 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Published March 9, 2012, doi:10.4049/jimmunol.1103024 The Journal of Immunology Canonical Type I IFN Signaling in Simian Immunodeficiency Virus-Infected Macrophages Is Disrupted by Astrocyte-Secreted CCL2 Luna Alammar Zaritsky,* Lucio Gama,* and Janice E. Clements*,† HIV-associated neurologic disorders are a mounting problem despite the advent of highly active antiretroviral therapy. To address mechanisms of HIV-associated neurologic disorders, we used an SIV pigtailed macaque model to study innate immune responses in brain that suppress viral replication during acute infection. -
ACS Style Guide
➤ ➤ ➤ ➤ ➤ The ACS Style Guide ➤ ➤ ➤ ➤ ➤ THIRD EDITION The ACS Style Guide Effective Communication of Scientific Information Anne M. Coghill Lorrin R. Garson Editors AMERICAN CHEMICAL SOCIETY Washington, DC OXFORD UNIVERSITY PRESS New York Oxford 2006 Oxford University Press Oxford New York Athens Auckland Bangkok Bogotá Buenos Aires Calcutta Cape Town Chennai Dar es Salaam Delhi Florence Hong Kong Istanbul Karachi Kuala Lumpur Madrid Melbourne Mexico City Mumbai Nairobi Paris São Paulo Singapore Taipei Tokyo Toronto Warsaw and associated companies in Berlin Idaban Copyright © 2006 by the American Chemical Society, Washington, DC Developed and distributed in partnership by the American Chemical Society and Oxford University Press Published by Oxford University Press, Inc. 198 Madison Avenue, New York, NY 10016 Oxford is a registered trademark of Oxford University Press All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of the American Chemical Society. Library of Congress Cataloging-in-Publication Data The ACS style guide : effective communication of scientific information.—3rd ed. / Anne M. Coghill [and] Lorrin R. Garson, editors. p. cm. Includes bibliographical references and index. ISBN-13: 978-0-8412-3999-9 (cloth : alk. paper) 1. Chemical literature—Authorship—Handbooks, manuals, etc. 2. Scientific literature— Authorship—Handbooks, manuals, etc. 3. English language—Style—Handbooks, manuals, etc. 4. Authorship—Style manuals. I. Coghill, Anne M. II. Garson, Lorrin R. III. American Chemical Society QD8.5.A25 2006 808'.06654—dc22 2006040668 1 3 5 7 9 8 6 4 2 Printed in the United States of America on acid-free paper ➤ ➤ ➤ ➤ ➤ Contents Foreword.