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Highlights of the São Paulo ISEV Workshop on Extracellular Vesicles in Cross-Kingdom Communication Journal of Extracellular Vesicles ISSN: (Print) 2001-3078 (Online) Journal homepage: http://www.tandfonline.com/loi/zjev20 Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication Rodrigo P. Soares, Patrícia Xander, Adriana Oliveira Costa, Antonio Marcilla, Armando Menezes-Neto, Hernando Del Portillo, Kenneth Witwer, Marca Wauben, Esther Nolte-`T Hoen, Martin Olivier, Miriã Ferreira Criado, Luis Lamberti P. da Silva, Munira Muhammad Abdel Baqui, Sergio Schenkman, Walter Colli, Maria Julia Manso Alves, Karen Spadari Ferreira, Rosana Puccia, Peter Nejsum, Kristian Riesbeck, Allan Stensballe, Eline Palm Hansen, Lorena Martin Jaular, Reidun Øvstebø, Laura de la Canal, Paolo Bergese, Vera Pereira-Chioccola, Michael W. Pfaffl, Joëlle Fritz, Yong Song Gho & Ana Claudia Torrecilhas To cite this article: Rodrigo P. Soares, Patrícia Xander, Adriana Oliveira Costa, Antonio Marcilla, Armando Menezes-Neto, Hernando Del Portillo, Kenneth Witwer, Marca Wauben, Esther Nolte- `T Hoen, Martin Olivier, Miriã Ferreira Criado, Luis Lamberti P. da Silva, Munira Muhammad Abdel Baqui, Sergio Schenkman, Walter Colli, Maria Julia Manso Alves, Karen Spadari Ferreira, Rosana Puccia, Peter Nejsum, Kristian Riesbeck, Allan Stensballe, Eline Palm Hansen, Lorena Martin Jaular, Reidun Øvstebø, Laura de la Canal, Paolo Bergese, Vera Pereira-Chioccola, Michael W. Pfaffl, Joëlle Fritz, Yong Song Gho & Ana Claudia Torrecilhas (2017) Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication, Journal of Extracellular Vesicles, 6:1, 1407213, DOI: 10.1080/20013078.2017.1407213 To link to this article: https://doi.org/10.1080/20013078.2017.1407213 © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Published online: 26 Nov 2017. Submit your article to this journal Article views: 939 View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=zjev20 JOURNAL OF EXTRACELLULAR VESICLES, 2017 VOL. 6, 1407213 https://doi.org/10.1080/20013078.2017.1407213 MEETING REPORT Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross- kingdom communication Rodrigo P. Soaresa,PatríciaXanderb*, Adriana Oliveira Costac, Antonio Marcilla d,e, Armando Menezes-Neto a, Hernando Del Portillof,g, Kenneth Witwer h,MarcaWaubeni, Esther Nolte-`T Hoeni,MartinOlivierj, Miriã Ferreira Criadok,LuisLambertiP.daSilvak, Munira Muhammad Abdel Baqui k, Sergio Schenkman l, Walter Collim, Maria Julia Manso Alvesm, Karen Spadari Ferreirab, Rosana Puccia l, Peter Nejsum n, Kristian Riesbecko, Allan Stensballep, Eline Palm Hansenq, Lorena Martin Jaularr,ReidunØvstebøs,LauradelaCanalt, Paolo Bergese u, Vera Pereira-Chioccolav, Michael W. Pfafflw, Joëlle Fritzx, Yong Song Ghoy and Ana Claudia Torrecilhasb aCentro de Pesquisas René Rachou/FIOCRUZ, Belo Horizonte; bLaboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Farmacêuticas, UNIFESP, São Paulo, Brazil; cDepartamento de Analises Clinicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; dÁrea de Parasitología, Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Universitat de València, Valencia, Spain; eJoint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Health Research Institute-La Fe, Universitat de València, Valencia, Spain; fICREA, Barcelona, Spain & ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; gInstitut d’Investigació Germans Trias i Pujol (IGTP), Badalona, Spain; hDepartment of Molecular and Comparative Pathobiology, and Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; iDepartment of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; jDepartment of Microbiology and Immunology, McGill University, Montréal, Canada; kDepartment of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; lDepartamento de Microbiologia, Imunologia e Parasitologia, UNIFESP, São Paulo, Brazil; mDepartamento de Bioquímica, IQ, USP, São Paulo, Brazil; nDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; oClinical Microbiology, Department of Translational Medicine, Lund University, Malmö, Sweden; pAalborg University, Aalborg, Denmark; qDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; rInstitut Curie, PSL Research University INSERM U932, Paris, France; sHead of the Blood Cell Research Group, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; tUniversity of Mar del Plata, Mar del Plata, Argentina; uDepartment of Molecular and Translational Medicine, INSTM, CSGI University of Brescia, Brescia, Italy; vAdolfo Lutz Institute, São Paulo, Brazil; wDepartment of Animal Physiology & Immunology, School of Life Science, Technical University of Munich, Freising Weihenstephan, Germany; xLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Luxembourg; yDepartment of Life Sciences, POSTECH (Pohang University of Science and Technology), Pohang, South Korea ABSTRACT ARTICLE HISTORY In the past years, extracellular vesicles (EVs) have become an important field of research since EVs Received 3 November 2017 have been found to play a central role in biological processes. In pathogens, EVs are involved in Accepted 11 November 2017 several events during the host–pathogen interaction, including invasion, immunomodulation, and pathology as well as parasite–parasite communication. In this report, we summarised the role KEYWORDS of EVs in infections caused by viruses, bacteria, fungi, protozoa, and helminths based on the talks Extracellular vesicles; and discussions carried out during the International Society for Extracellular Vesicles (ISEV) infectious diseases; workshop held in São Paulo (November, 2016), Brazil, entitled Cross-organism Communication pathogens; cell by Extracellular Vesicles: Hosts, Microbes and Parasites. communication; isolation The ISEV satellite meeting vesicle has currently been proposed to include exo- somes, microvesicles, and apoptotic bodies, which Extracellular vesicles (EVs) are prokaryotic and eukar- vary in size, number, and biogenesis [3]. yotic cellular components involved in communication Following a growing interest in the EV field for and in several processes ranging from infectious to 10 years, a group of scientists created the inflammatory diseases [1,2]. The structural and func- International Society for Extracellular Vesicles (ISEV), tional characterisation of EVs has been focused on following the International Workshop on Exosomes vesicles isolated from the extracellular milieu of cul- organised in Paris in January 2011. ISEV is a global tured cells in normal or pathological conditions and society, whose mission relies on spreading education, from microorganisms. The general term extracellular CONTACT Ana Claudia Torrecilhas [email protected] Universidade Federal de São Paulo, Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Rua São Nicolau, 210, Diadema, SP 09913-030, Brazil *These authors contributed equally to this work. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 2 R. P. SOARES ET AL. communication, and science among the different levels ubiquitination was implicated in incorporation of bac- of academia. Since then, six annual meetings promoted terial proteins into exosomes [8], although it is by the Society were held in different cities including unknown whether this mechanism is also used by Göteborg (2012), Boston (2013), Rotterdam (2014, other bacteria or microorganisms. Clearly, studies on 2016), Washington D.C. (2015), and Toronto (2017). the mechanisms for sorting selective pathogen-derived ISEV has also promoted satellite workshops that con- cargo into EVs might pave the way for discovering gregated 40–60 participants and have so far occurred in inhibitors of such mechanisms. New York (2012), Melbourne (2014), Budapest (2013), Another major topic in host–pathogen interaction is and Singapore (2015), among others. Considering that functional studies on the effect of transferring informa- infectious diseases are a major health problem in Brazil tion to recipient cells. Several examples currently sup- and other tropical countries, an ISEV workshop port that this transfer might facilitate the colonisation focused on EVs from pathogens was held in São of niches for pathogen invasion, exacerbate clinical Paulo, Brazil, in 2016. This meeting was organised by symptoms, and trigger immune responses, among local groups working in infectious disease-related EVs other effects [9,10]. A recent report on and ISEV Board and had the participation of scientists Paracoccidioides brasiliensis, which causes major fungal and students coming from many Brazilian cities as well lung complications, shows the importance of EVs in as other countries.
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