DOCSLIB.ORG

Vii PROGRAM MONDAY, December 12—7:00 PM Introductory Remarks

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

PROGRAM MONDAY, December 12—7:00 PM Introductory Remarks SESSION 1 KEYNOTE LECTURES Chairperson: Andrew Hill, La Trobe Institute for Molecular Science, Melbourne, Australia Identification of a membrane transporter to uptake mature microRNA Chen-Yu Zhang, Ke Zen, Qipeng Zhang, Qun Chen, Fan Zhang, Lei Dong [50’+10’] Presenter affiliation: Najing University, Najing, China. 1 Exploiting exosomes biology in the diagnosis and treatment of pancreatic cancer Raghu Kalluri [50’+10’] Presenter affiliation: MD Anderson Cancer Center, Houston, Texas. 2 TUESDAY, December 13—9:00 AM SESSION 2 LOADING AND FUNCTIONAL TRANSFER OF EV RNA Chairperson: Janusz Rak, McGill University, Montréal, Canada Mechanisms of miRNA activity regulation by EV mediated export in mammalian cells Suvendra N. Bhattacharyya [25’+10’] Presenter affiliation: CSIR-Indian Institute of Chemical Biology, Kolkata, India. 3 vii Exosomes derived from mesenchymal phenotype lung cancer cells promote epithelial mesenchymal transition in epithelial cells through transfer of distinct small RNA cargo Yueting Tang, Yiyao Huang, Sihua Qin, Yong Xu, Taixue An, Lei Zheng [25’+10’] Presenter affiliation: Nanfang Hospital, Southern Medical University, 4 Guangzhou, China. Coffee Break Exosomal transfer of MiR-151a enhances chemosensitivity to temozolomide in glioblastoma by targeting XRCC4 Ailiang Zeng, Wei Yan, Yongping You [10’+5’] Presenter affiliation: The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 5 RNA profiles of three subtypes of extracellular vesicles released by human colorectal cancer LIM1863 cell lines Maoshan Chen, Rong Xu, Hong Ji, David Greening, Alin Rai, Richard Simpson [10’+5’] Presenter affiliation: Department of Biochemistry and Genetics, Melbourne, Victoria, Australia. 6 Ubiquitination controls miRNA-binding of HuR and augments extracellular export of miRNA Kamalika Mukherjee, Suvendra N. Bhattacharyya [10’+5’] Presenter affiliation: CSIR-Indian Institute of Chemical Biology, Kolkata, India. 7 Extracellular vesicle-mediated transfer of functional RNA between tissues Stefan Momma [25’+10’] Presenter affiliation: University Hospital Frankfurt, Frankfurt am Main, Germany. 8 viii TUESDAY, December 13—2:00 PM SESSION 3 POSTER SESSION Calcium-calpain dependent pathways regulate vesiculation in malignant breast cells Jack D. Taylor, Gregory R. Monteith, Mary Bebawy Presenter affiliation: The University of Technology Sydney, Sydney, Australia. 9 Long term stability of isolated human serum derived exosomes Candice de Boer, Neil H. Davies Presenter affiliation: University of Cape Town, Cape Town, South Africa. 10 Characterization of the DNA content of extracellular vesicle subsets Elisa Lázaro-Ibáñez, Rossella Crescitelli, Anaís García, Ganesh Shelke, Cecilia Lässer, Jan Lötvall Presenter affiliation: Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden; Centre for Drug Research, Faculty of Pharmacy, Helsinki, Finland. 11 Exosomes secreted from human iPS-derived mesenchymal stem cells prevent osteonecrosis of the femoral head by promoting angiogenesis Qing Li, Xiaolin Liu, Xin Niu, Bin Hu, Yang Wang Presenter affiliation: Institute of Microsurgery on Extremities, Shanghai, China. 12 BRAFV600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells Taral R. Lunavat, Lesley Cheng, Berglind O. Einarsdottir, Roger O. Bagge, Robin A. Sharples, Cecilia Lässer, Yong S. Gho, Andrew F. Hill, Jonas A. Nilsson, Jan Lötvall Presenter affiliation: Krefting Research Centre, Gothenburg, Sweden. 13 Human iPSC-derived extracellular vesicles—Characterization of their properties in vitro and in vivo Vasiliki Machairaki, Hao Bai, Yongxing Gao, Samarjit Das, Kenneth Kenneth Witwer, Linzhao Cheng Presenter affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland. 14 ix Optimized EV isolation and EV-derived miRNA analysis from urine and stool for colorectal cancer diagnosis Seung-ick Oh, Sookil Tae, Seokjin Ham, Hyunjoo Ko, Insoon Jang, Tae-Young Roh Presenter affiliation: Pohang University of Science and Technology, Pohang, South Korea. 15 Exosomes isolated from 3D-physiological oxygen cultured human Wharton’s Jelly-derived mesenchymal stem cells (MSCs) induce cell death in the in-vitro cultured MCF 7 cells Balasubramanian Sundaram, Sanjay Kumar Presenter affiliation: Centre for Stem Cell Research, A unit of inStem Bengaluru, Christian Medical College, Vellore, India. 16 Intercellular transmission of molecular chaperones via exosomes contributes to maintenance of organismal protein homeostasis Toshihide Takeuchi, Mari Suzuki, Nobuhiro Fujikake, Akiko H. Popiel, Hisae Kikuchi, Satoko Sakai, Shiroh Futaki, Keiji Wada, Yoshitaka Nagai Presenter affiliation: Osaka University, Osaka, Japan; National Center of Neurology and Psychiatry, Tokyo, Japan; Kyoto University, Kyoto, Japan. 17 Surface charge and pattern analysis as promising differentiating tools in scanning NTA Alireza Fazeli, Clemens Helmbrecht, Hanno Wachernig, Sascha Raschke Presenter affiliation: ; Particle Metrix, Meerbusch, Germany. 18 Exosomes secreted by human urine derived stem cells improves functional recovery after stroke in rats Guowei Zhang, Qingwei Zhu, Xiaozheng Ling, Xin Niu, Yang Wang, Zhifeng Deng Presenter affiliation: Institute of Microsurgery on Extremities, Shanghai, China. 19 Ionizing radiation affects miRNA composition of exosomes Yi Wang, Sukhmani Billing, Michelle Budgen, Kei Cheng Mak, Farrah Flegal, Dmitry Klokov Presenter affiliation: Canadian Nuclear Laboratories, Chalk River, Canada. 20 x Exosomes—Characteristic and significance of cancer patient plasma Meng Xia, Ming-Bo Huang, Zhao Gao, Jing Leng Presenter affiliation: Guangxi University of Chinese Medicine, Nanning, China. 21 Curvature sensing MARCKS-ED peptides bind to membranes in a stereo-independent manner Lei Yan, Armando Jerome de Jesus, Ryo Tamura, Victoria Li, Kui Cheng, Hang Yin Presenter affiliation: Tsinghua University, Beijing, China. 22 Curcuma longa-derived nanoparticles reduce colitis and promote intestinal wound repair by inactivating NF-κB pathway Mingzhen Zhang, Emilie Viennois, Moon Kwon Han, Changlong Xu, Didier Merlin Presenter affiliation: Georgia State University, Atlanta, Georgia. 23 Impact of extracellular vesicles on host immune responses mediated by endosomal Toll-like receptors Ying Zhang, Hang Yin Presenter affiliation: Center of Basic Molecular Science, Beijing, China. 24 Thrombin-activated platelets-derived exosomes regulate ICAM-1 expression of endothelial cell via microRNA-223 in thrombosis- inflammation reaction Jiannan Li, Hongbing Yan, Zhou Zhou Presenter affiliation: Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 25 Exosomes released from human-induced pluripotent stem cell- derived mesenchymal stem cells have superior effects than exosomes released from human synovial membrane derived mesenchymal stem cells for the treatment of osteoarthritis Yu Zhu, Yuchen Wang, Xin Niu, Yang Wang, Yunfeng Chen Presenter affiliation: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China. 26 TUESDAY, December 13—4:30 PM Chinese Tea and Beer Tasting xi TUESDAY, December 13—7:00 PM SESSION 4 EVs AND THE CENTRAL NERVOUS SYSTEM Chairperson: Vasiliki Machairaki, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA The role of extracellular vesicles in neurodegenerative diseases Andrew F. Hill [25’+10’] Presenter affiliation: La Trobe University, Bundoora, Australia. 27 Exosomes in neural cell communication—'Goodies' for neuronal fitness? Wen-Ping Kuo-Elsner, Carsten Frühbeis, Dominik Fröhlich, Eva-Maria Krämer-Albers [25’+10’] Presenter affiliation: Johannes Gutenberg University (JGU) Mainz, Mainz, Germany. 28 Are exosomes responsible for the intercellular spread of Alzheimer's disease neuropathology? Laura J. Vella, Benjamin Scicluna, Lesley Cheng, Andrew F. Hill, Kevin Barnham [10’+5’] Presenter affiliation: The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. 29 The extracellular vesicle environment in cell growth and HIV-1 production Kenneth W. Witwer [25’+10’] Presenter affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland. 30 xii WEDNESDAY, December 14—9:00 AM SESSION 5 VESICLES: NOT JUST FOR MAMMALS Chairperson: Kenneth Witwer, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA EV-mediated transfer of RNA between helminths and their mammalian Hosts Amy H. Buck [25’+10’] Presenter affiliation: University of Edinburgh, Edinburgh, United Kingdom. 31 Trypanosoma cruzi Trypomastigotes release EVs containing proinflammatory virulence factors that enhance host-cell invasion by Toll like receptor 2 Ana Claudia Torrecilhas, Rodrigo P. Soares [25’+10’] Presenter affiliation: UNIFESP, São Paulo, Brazil. 32 Coffee Break Lipophosphoglycan (LPG), the major Leishmania surface glycoconjugate, is found in the extracellular vesicles (EVs) of Leishmania infantum and Leishmania braziliensis Rodrigo P. Soares, Armando Menezes-Neto, Blima Fux, Ana C. Torrecilhas [10’+5’] Presenter affiliation: Centro de Pesquisas René Rachou/Fiocruz, Belo Horizonte, Brazil. 33 Gyongyi Szabo [25’+10’] Presenter affiliation: University of Massachusetts Medical School, Worcester, Massachusetts. Extracellular membrane vesicles in hyperthermophilic archaea Sukhvinder Gill, Rie Matsumi, Evelyne Marguet, Jacques Oberto, Patrick Forterre [10’+5’] Presenter affiliation: Institute for Integrative Biology of the Cell (I2BC),
Recommended publications
  • Attenuation of Pathogenic Immune Responses During Infection with Human and Simian Immunodeficiency Virus (HIV/SIV) by the Tetracycline Derivative Minocycline

    Attenuation of Pathogenic Immune Responses During Infection with Human and Simian Immunodeficiency Virus (HIV/SIV) by the Tetracycline Derivative Minocycline

    Attenuation of Pathogenic Immune Responses during Infection with Human and Simian Immunodeficiency Virus (HIV/SIV) by the Tetracycline Derivative Minocycline Julia L. Drewes1, Gregory L. Szeto1¤, Elizabeth L. Engle1, Zhaohao Liao1, Gene M. Shearer2,M. Christine Zink1*, David R. Graham1,3* 1 Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Johns Hopkins Bayview Proteomics Center, Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine Bayview Campus, Baltimore, Maryland, United States of America Abstract HIV immune pathogenesis is postulated to involve two major mechanisms: 1) chronic innate immune responses that drive T cell activation and apoptosis and 2) induction of immune regulators that suppress T cell function and proliferation. Both arms are elevated chronically in lymphoid tissues of non-natural hosts, which ultimately develop AIDS. However, these mechanisms are not elevated chronically in natural hosts of SIV infection that avert immune pathogenesis despite similarly high viral loads. In this study we investigated whether minocycline could modulate these pathogenic antiviral responses in non-natural hosts of HIV and SIV. We found that minocycline attenuated in vitro induction of type I interferon (IFN) and the IFN-stimulated genes indoleamine 2,3-dioxygenase (IDO1) and TNF-related apoptosis inducing ligand (TRAIL) in human plasmacytoid dendritic cells and PBMCs exposed to aldrithiol-2 inactivated HIV or infectious influenza virus. Activation- induced TRAIL and expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4) in isolated CD4+ T cells were also reduced by minocycline.
  • University of Groningen Mechanics of Extracellular Vesicles

    University of Groningen Mechanics of Extracellular Vesicles

    University of Groningen Mechanics of extracellular vesicles derived from malaria parasiteinfected Red Blood Cells Sorkin, Raya; Vorselen, Daan; Ofir-Birin, Yifat; Roos, Wouter H.; MacKintosh, Fred C.; Regev-Rudzki, Neta; Wuite, Gijs J. L. Published in: Journal of Extracellular Vesicles DOI: 10.3402/jev.v5.31552 IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Sorkin, R., Vorselen, D., Ofir-Birin, Y., Roos, W. H., MacKintosh, F. C., Regev-Rudzki, N., & Wuite, G. J. L. (2016). Mechanics of extracellular vesicles derived from malaria parasiteinfected Red Blood Cells. Journal of Extracellular Vesicles, 5, 86. https://doi.org/10.3402/jev.v5.31552 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 12-11-2019
  • Human Perivascular Stem Cell-Derived Extracellular Vesicles Mediate Bone

    Human Perivascular Stem Cell-Derived Extracellular Vesicles Mediate Bone

    RESEARCH ARTICLE Human perivascular stem cell-derived extracellular vesicles mediate bone repair Jiajia Xu1, Yiyun Wang1, Ching-Yun Hsu1, Yongxing Gao1, Carolyn Ann Meyers1, Leslie Chang1, Leititia Zhang1,2, Kristen Broderick3, Catherine Ding4, Bruno Peault4,5,6, Kenneth Witwer7,8, Aaron Watkins James1* 1Department of Pathology, Johns Hopkins University, Baltimore, United States; 2Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China; 3Department of Surgery, Johns Hopkins University, Baltimore, United States; 4Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, UCLA, Orthopaedic Hospital, Los Angeles, United States; 5Centre For Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; 6MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom; 7Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, United States; 8Department of Neurology, Johns Hopkins University, Baltimore, United States Abstract The vascular wall is a source of progenitor cells that are able to induce skeletal repair, primarily by paracrine mechanisms. Here, the paracrine role of extracellular vesicles (EVs) in bone healing was investigated. First, purified human perivascular stem cells (PSCs) were observed to induce mitogenic, pro-migratory, and pro-osteogenic effects on osteoprogenitor cells while in non- contact co-culture via elaboration of EVs. PSC-derived EVs shared mitogenic, pro-migratory, and pro-osteogenic properties of their parent cell. PSC-EV effects were dependent on surface- associated tetraspanins, as demonstrated by EV trypsinization, or neutralizing antibodies for CD9 or CD81. Moreover, shRNA knockdown in recipient cells demonstrated requirement for the CD9/ CD81 binding partners IGSF8 and PTGFRN for EV bioactivity. Finally, PSC-EVs stimulated bone repair, and did so via stimulation of skeletal cell proliferation, migration, and osteodifferentiation.
  • Announcing the ISEV2020 Special Achievement Award Recipients

    Announcing the ISEV2020 Special Achievement Award Recipients

    Thomas Jefferson University Jefferson Digital Commons Kimmel Cancer Center Faculty Papers Kimmel Cancer Center 10-1-2020 Announcing the ISEV2020 special achievement award recipients: Andrew Hill and Edit Buzás; and the recipient of the ISEV2020 special education award: Carolina Soekmadji. Kenneth W Witwer Lucia R Languino Alissa M Weaver Marca H Wauben Follow this and additional works at: https://jdc.jefferson.edu/kimmelccfp Part of the Oncology Commons Let us know how access to this document benefits ouy This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in Kimmel Cancer Center Faculty Papers by an authorized administrator of the Jefferson Digital Commons. For more information, please contact: [email protected]. Received: 30 July 2020 Accepted: 8 September 2020 DOI: 10.1002/jev2.12021 EDITORIAL Announcing the ISEV special achievement award recipients: AndrewHillandEditBuzás;andtherecipientoftheISEV special education award: Carolina Soekmadji The International Society for Extracellular Vesicles (ISEV) is pleased to announce two Special Achievement Awards that were presented at the virtual ISEV2020 annual meeting, 20–22 July 2020. ISEV Special Achievement Awards are given each year to one or more individuals who have made outstanding contributions to the field of extracellular vesicle (EV) research or have per- formed extraordinary service to ISEV (Witwer, Hill, & Tahara, 2019).
  • Isct2021 Program

    Isct2021 Program

    MAY 26–28 ISCT2021 VIRTUAL Orchestrating Global CGT Translation Building Consensus for the Path Forward PROGRAM MAY 26–28 ISCT2021 VIRTUAL WELCOME FROM THE ISCT PRESIDENT Dear Friends and Colleagues, a day, 3 concurrent tracks), and all of which will be available for viewing on demand for the remainder of 2021. Extra effort We ARE friends AND colleagues! Just as ISCT is a Society has been invested for enhanced virtual Networking, with a full like no other, ISCT 2021 Virtual New Orleans will continue ISCT 2021 Networking Day on May 25. During the Networking our breakthrough last year in providing a virtual platform Day, you can attend the inaugural Investigators to Investors with industry leading presentation technology that is im- (I to I) Workshop, organized by the ISCT Business Models & mersive and informative, enlightening and engaging in a Investment Commercialization Sub-Committee, which will multi-dimensional platform that reflects our Society values. bring together cell and gene therapy investors for a half-day We promote innovation in translational research. We strive educational event providing unparalleled access to cell and for excellence in everything we do. We respect and support gene therapy key opinion leaders. diversity and inclusivity. We uphold the highest ethical stan- dards. We serve our members and advocate for our Society. The anchor for your ISCT program is the six plenary ses- sions. Leading off, our President Elect Jacques Galipeau Over the past year, the world has seen great tragedy and will chair the plenary “COVID-19: Understanding the Path scientific advances to meet pandemic challenges. The field Forward for Mesenchymal Stromal Cell Therapies.” For the of cell and gene therapy continues to break new ground, Presidential Plenary, representing the Commercialization advancing medical care for patients worldwide.
  • Extracellular Vesicles and Nanoerythrosomes: the Hidden Pearls of Blood Products

    Extracellular Vesicles and Nanoerythrosomes: the Hidden Pearls of Blood Products

    Academic Dissertations from The Finnish Red Cross Blood Service number 64 SAMI VALKONEN | Extracellular Vesicles and Nanoerythrosomes: The Hidden Pearls of Blood Products Blood Nanoerythrosomes: Pearls of Extracellular and Hidden The | Vesicles SAMI VALKONEN SAMI VALKONEN Extracellular Vesicles and Nanoerythrosomes: The Hidden Pearls of Blood Products ISBN 978-952-5457-48-3 (print) ISBN 978-952-5457-49-0 (pdf) ISSN 1236-0341 FRC BS: 64 http://ethesis.helsinki.fi Turku 2019 Painosalama Oy ACADEMIC DISSERTATION, NUMBER 64 Doctoral School of Health Sciences Doctoral Programme in Biomedicine Molecular and Integrative Biosciences Research Programme Faculty of Biological and Environmental Sciences University of Helsinki and Finnish Red Cross Blood Service EXTRACELLULAR VESICLES AND NANOERYTHROSOMES: THE HIDDEN PEARLS OF BLOOD PRODUCTS Sami Valkonen ACADEMIC DISSERTATION To be presented for public examination, with the permission of the Faculty of Biological and Environmental Sciences of the University of Helsinki, in Nevanlinna Auditorium of the Finnish Red Cross Blood Service, Kivihaantie 7, Helsinki, on 19th December 2019, at 12 noon. Helsinki 2019 ACADEMIC DISSERTATIONS FROM THE FINNISH RED CROSS BLOOD SERVICE, NUMBER 64 Supervisors Adjunct Professor Pia Siljander Faculty of Biological and Environmental Sciences University of Helsinki Doctor Saara Laitinen Department of Research & Development Finnish Red Cross Blood Service Thesis Committee Associate Professor Susanna Fagerholm Faculty of Biological and Environmental Sciences University of
  • Downloaded From

    Downloaded From

    Canonical Type I IFN Signaling in Simian Immunodeficiency Virus-Infected Macrophages Is Disrupted by Astrocyte-Secreted CCL2 This information is current as of September 27, 2021. Luna Alammar Zaritsky, Lucio Gama and Janice E. Clements J Immunol published online 9 March 2012 http://www.jimmunol.org/content/early/2012/03/09/jimmun ol.1103024 Downloaded from Why The JI? Submit online. http://www.jimmunol.org/ • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average by guest on September 27, 2021 Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2012 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Published March 9, 2012, doi:10.4049/jimmunol.1103024 The Journal of Immunology Canonical Type I IFN Signaling in Simian Immunodeficiency Virus-Infected Macrophages Is Disrupted by Astrocyte-Secreted CCL2 Luna Alammar Zaritsky,* Lucio Gama,* and Janice E. Clements*,† HIV-associated neurologic disorders are a mounting problem despite the advent of highly active antiretroviral therapy. To address mechanisms of HIV-associated neurologic disorders, we used an SIV pigtailed macaque model to study innate immune responses in brain that suppress viral replication during acute infection.
  • NCUR Proceedings

    NCUR Proceedings

    NCUR 2021 Proceedings A Diffusion Approach for Plasma Synthesis of Superhard Tantalum Borides Physics/Astronomy - Time: Tue 3:30pm-4:30pm - Session Number: 745 Aaditya Rau, Dr. Aaron Catledge, Department of Physics, The University of Alabama at Birmingham, 1720 2nd Ave S, Birmingham, Alabama 35294 Aaditya Rau Tantalum borides are a set of refractory metal compounds that have become of interest due to their desirable mechanical, thermal, and electrical properties. While these compounds have been previously synthesized in a variety of methods, key issues related to sample size, sample integrity, and implementation feasibility limit their use. In this study, a microwave plasma chemical vapor deposition (MPCVD) reactor was used to diffuse boron into tantalum substrates using a feedgas mixture of hydrogen and diborane. Specifically, the role of substrate temperature and substrate bias in influencing the chemical composition and mechanical properties of the borided tantalum was investigated. X-ray diffraction shows that high substrate temperature is favorable for TaB2 formation, with samples made at great than 775°C having a mean surface hardness of 40 GPa along with increased strain in the tantalum body-centered cubic lattice. Once the strained tantalum becomes locally supersaturated with boron, TaB and TaB2 precipitate. The combination of precipitation hardening as well as solid solution hardening may help explain the measured superhardness, as measured by nanoindentation. Application of a negative bias voltage to the substrate during the CVD process was not found to further increase the hardness, and in some cases decreased the measured hardness significantly, possibly due to etching effects from increased ion bombardment. These results show that MPCVD is a viable method for synthesis of superhard borides based on plasma-assisted diffusion.
  • Pharmacokinetics and Biodistribution of Extracellular Vesicles Administered Intravenously and Intranasally to Macaca Nemestrina

    Pharmacokinetics and Biodistribution of Extracellular Vesicles Administered Intravenously and Intranasally to Macaca Nemestrina

    bioRxiv preprint doi: https://doi.org/10.1101/2021.07.28.454192; this version posted July 29, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina Authors Tom Driedonks1, Linglei Jiang1, Bess Carlson 1, Zheng Han2,3, Guanshu Liu2,3, Suzanne E. Queen1, Erin N. Shirk1, Olesia Gololobova1, Lyle Nyberg1, Gabriela Lima1, Kayla Schonvisky1, Natalie Castell1, Mitchel Stover, Selena Guerrero-Martin1,4, Riley Richardson1, Barbara Smith5, Charles P. Lai6, Jessica M. Izzi1, Eric K. Hutchinson1, Kelly A.M. Pate1,4, Kenneth W. Witwer1,7,8,* 1. Dept. Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, US 2. Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, US 3. F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, US 4. Division of ComParative Medicine and DePartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, US 5. DePt. Cell Biology, Johns HoPkins University School of Medicine, Baltimore, MD, US 6. Institute of Atomic and Molecular Sciences, Academia Sinica, TaiPei, Taiwan 7. DePt. of Neurology, Johns HoPkins University School of Medicine, Baltimore, MD, US 8. The Richman Family Precision Medicine Center of Excellence in Alzheimer’s Disease, Johns Hopkins University School of Medicine, Baltimore, MD, US *CorresPondence: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2021.07.28.454192; this version posted July 29, 2021.
  • Highlights of the São Paulo ISEV Workshop on Extracellular Vesicles in Cross-Kingdom Communication

    Highlights of the São Paulo ISEV Workshop on Extracellular Vesicles in Cross-Kingdom Communication

    Journal of Extracellular Vesicles ISSN: (Print) 2001-3078 (Online) Journal homepage: http://www.tandfonline.com/loi/zjev20 Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication Rodrigo P. Soares, Patrícia Xander, Adriana Oliveira Costa, Antonio Marcilla, Armando Menezes-Neto, Hernando Del Portillo, Kenneth Witwer, Marca Wauben, Esther Nolte-`T Hoen, Martin Olivier, Miriã Ferreira Criado, Luis Lamberti P. da Silva, Munira Muhammad Abdel Baqui, Sergio Schenkman, Walter Colli, Maria Julia Manso Alves, Karen Spadari Ferreira, Rosana Puccia, Peter Nejsum, Kristian Riesbeck, Allan Stensballe, Eline Palm Hansen, Lorena Martin Jaular, Reidun Øvstebø, Laura de la Canal, Paolo Bergese, Vera Pereira-Chioccola, Michael W. Pfaffl, Joëlle Fritz, Yong Song Gho & Ana Claudia Torrecilhas To cite this article: Rodrigo P. Soares, Patrícia Xander, Adriana Oliveira Costa, Antonio Marcilla, Armando Menezes-Neto, Hernando Del Portillo, Kenneth Witwer, Marca Wauben, Esther Nolte- `T Hoen, Martin Olivier, Miriã Ferreira Criado, Luis Lamberti P. da Silva, Munira Muhammad Abdel Baqui, Sergio Schenkman, Walter Colli, Maria Julia Manso Alves, Karen Spadari Ferreira, Rosana Puccia, Peter Nejsum, Kristian Riesbeck, Allan Stensballe, Eline Palm Hansen, Lorena Martin Jaular, Reidun Øvstebø, Laura de la Canal, Paolo Bergese, Vera Pereira-Chioccola, Michael W. Pfaffl, Joëlle Fritz, Yong Song Gho & Ana Claudia Torrecilhas (2017) Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication, Journal of Extracellular Vesicles, 6:1, 1407213, DOI: 10.1080/20013078.2017.1407213 To link to this article: https://doi.org/10.1080/20013078.2017.1407213 © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
  • Summary of the ISEV Workshop on Extracellular Vesicles As Disease Biomarkers, Held in Birmingham, UK, During December 2017

    Summary of the ISEV Workshop on Extracellular Vesicles As Disease Biomarkers, Held in Birmingham, UK, During December 2017

    Journal of Extracellular Vesicles ISSN: (Print) 2001-3078 (Online) Journal homepage: https://www.tandfonline.com/loi/zjev20 Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017 Aled Clayton, Dominik Buschmann, J. Brian Byrd, David R. F. Carter, Lesley Cheng, Carolyn Compton, George Daaboul, Andrew Devitt, Juan Manuel Falcon-Perez, Chris Gardiner, Dakota Gustafson, Paul Harrison, Clemens Helmbrecht, An Hendrix, Andrew Hill, Andrew Hoffman, Jennifer C. Jones, Raghu Kalluri, Ji Yoon Kang, Benedikt Kirchner, Cecilia Lässer, Charlotte Lawson, Metka Lenassi, Carina Levin, Alicia Llorente, Elena S. Martens- Uzunova, Andreas Möller, Luca Musante, Takahiro Ochiya, Ryan C Pink, Hidetoshi Tahara, Marca H. M. Wauben, Jason P. Webber, Joshua A. Welsh, Kenneth W. Witwer, Hang Yin & Rienk Nieuwland To cite this article: Aled Clayton, Dominik Buschmann, J. Brian Byrd, David R. F. Carter, Lesley Cheng, Carolyn Compton, George Daaboul, Andrew Devitt, Juan Manuel Falcon-Perez, Chris Gardiner, Dakota Gustafson, Paul Harrison, Clemens Helmbrecht, An Hendrix, Andrew Hill, Andrew Hoffman, Jennifer C. Jones, Raghu Kalluri, Ji Yoon Kang, Benedikt Kirchner, Cecilia Lässer, Charlotte Lawson, Metka Lenassi, Carina Levin, Alicia Llorente, Elena S. Martens-Uzunova, Andreas Möller, Luca Musante, Takahiro Ochiya, Ryan C Pink, Hidetoshi Tahara, Marca H. M. Wauben, Jason P. Webber, Joshua A. Welsh, Kenneth W. Witwer, Hang Yin & Rienk Nieuwland (2018) Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017, Journal of Extracellular Vesicles, 7:1, 1473707, DOI: 10.1080/20013078.2018.1473707 To link to this article: https://doi.org/10.1080/20013078.2018.1473707 © 2018 The Author(s).
  • Top Candidates of Ukraine's Leading Parties Ukraine's Parliamentary

    Top Candidates of Ukraine's Leading Parties Ukraine's Parliamentary

    INSIDE: l Yanukovych signs the language law – pages 2 and 6 l Medal-winning performances at the Olympics – page 5 l Red Hot Chili Peppers in concert in Kyiv – page 14 THEPublished U by theKRAINIAN Ukrainian National Association Inc., a fraternal W non-profit associationEEKLY Vol. LXXX No. 33 THE UKRAINIAN WEEKLY SUNDAY, AUGUST 12, 2012 $1/$2 in Ukraine Top candidates Ukraine’s parliamentary election campaign begins of Ukraine’s Regions, Batkivshchyna leading parties present their candidates by Zenon Zawada Following is information on the Special to The Ukrainian Weekly top five candidates on the party lists KYIV – Ukraine’s parliamentary election of the Party of Regions of Ukraine campaign kicked off officially on July 30 and the Batkivshchyna Party. when the country’s two leading political forces, the Party of Regions of Ukraine and Party of the Regions of Ukraine the Batkivshchyna party, held their con- 1. Mykola Azarov – 64, prime gresses to present their candidates. minister of Ukraine. Born in Russia, The styles of the congress demonstrated Mr. Azarov was a geologist before his their sharply contrasting political situations. meteoric rise in politics. On the Members of the Party of Regions gath- Melnychenko tapes, a voice similar to ered at the International Exhibition Center Mr. Azarov’s is recorded as planning across the street from the Resurrection of Aleksandr Sinitsa/UNIAN election fraud in the 1999 presidential Christ Ukrainian Catholic Patriarchal Arseniy Yatsenyuk (left) and Anatoliy Grytsenko led the Batkivshchyna party con- vote with former President Leonid Cathedral, overlooking the Dnipro River. gress on July 30 as it nominated its candidates for the parliamentary elections.