bioRxiv preprint doi: https://doi.org/10.1101/2021.07.28.454192; this version posted July 29, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina Authors Tom Driedonks1, Linglei Jiang1, Bess Carlson 1, Zheng Han2,3, Guanshu Liu2,3, Suzanne E. Queen1, Erin N. Shirk1, Olesia Gololobova1, Lyle Nyberg1, Gabriela Lima1, Kayla Schonvisky1, Natalie Castell1, Mitchel Stover, Selena Guerrero-Martin1,4, Riley Richardson1, Barbara Smith5, Charles P. Lai6, Jessica M. Izzi1, Eric K. Hutchinson1, Kelly A.M. Pate1,4, Kenneth W. Witwer1,7,8,* 1. Dept. Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, US 2. Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, US 3. F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, US 4. Division of ComParative Medicine and DePartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, US 5. DePt. Cell Biology, Johns HoPkins University School of Medicine, Baltimore, MD, US 6. Institute of Atomic and Molecular Sciences, Academia Sinica, TaiPei, Taiwan 7. DePt. of Neurology, Johns HoPkins University School of Medicine, Baltimore, MD, US 8. The Richman Family Precision Medicine Center of Excellence in Alzheimer’s Disease, Johns Hopkins University School of Medicine, Baltimore, MD, US *CorresPondence:
[email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2021.07.28.454192; this version posted July 29, 2021.