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Get High-Res Image 25 Syn. Frame shift 20 Missense In frame inA94 Syn. 15 Splice site Other non syn. Non syn. 10 Nonsense 5 # mutations/#< 0 239 50% 1HL 143 31% $-&#1 5% DNMT1 4% 'IAA0408 4% CCDC136 4% SMG7 3% CCDC91 3% ARA$3 3% D$$3 3% TAS2R3 3% ACSL3 3% !FN-3 3% NAPSA 3% (SB$L3 3% SPD2E3 2% C1S 2% $KD2 2% SLC26A4 2% TSKS 2% $"2" 2% (R4A47 2% $&!$ 2% SDHAF2 2% SLC4A5 2% A&$C2 2% CHS21 2% $DE9A 2% &RAS2 2% T&" 2% NET(2 2% $CG 1 2% &-$JL 2% SHANK1 2% ZMAT2 1% AP 1% -*(24 1% NSFL1C 1% N+D1 1% $&-1 1% $*#$2 1% SLC35 1 1% D"&S* 1% !RN2 1% (R9,1 1% $AX2 1% &ASAL1 1% &NF168 1% SNRNP70 1% TATDN2 1% -#$8A 1% C$-2 1% G) 1 1% #$( 53 11% SETD2 4% $TEN 6% 'DM5C 5% -AP1 3% TP53 37 7% #TO& 2% S$&24 2% S(&D 2% (R4D1 2% SLC6A7 2% C%-3 3% LET#1 2% NAT8 2% AM122C 2% !XTL2 2% !GR1 2% #AR'4 2% #&$L10 2% $CG 2 79 11% #UC4 2% DCA 11 1% CDC42EP3 2% SLC30A9 1% -# 2% CEC&1 2% CCDC97 1% C$(* 2% CDH&1 2% LET#D1 3% CAMTA2 1% TSPAN19 2% D$!$2 2% ZNF280A 1% NPL 1% !#$2 2% "PS3 2% $LOD3 1% ZNF512 1% T%#P3 1% SLC43A3 2% ZNF625 1% TCE-1 1% LDLRA$1 1% ANK&D23 1% SLC43A1 2% CD4 2% ZDH"C5 2% ANG$TL6 1% %$6K2 2% &-#23 1% IGSF5 2% &PS6KA1 1% 2% 1A 1% -RA$ 2% NACA 2% A#"&2 1% C&2-B1 1% 1PS33A 1% ATP2A3 2% ABCC1 1% G#!-1 1% )-*N7 1% (R4 15 2% DCDC1 1% !MG1 1% T#!#229A 0% (R2A25 1% $OL&2F 2% N! " 1% (R4D11 2% SCN4A 2% TBC1D8- 1% 'IAA1919 1% !LO1L5 1% TES'1 1% S!#A4F 2% T"-S1 1% $&'AA2 1% SLC18A2 1% $TG!R3 3% DNMT3A 1% #TF&1 1% TTF2 1% #'* 1% !DIL3 1% ZAD"2 1% TAGLN3 0% C4orf47 1% ASRGL1 2% ATN1 2% ZBTB39 1% (R4'5 2% T#!#145 4% &AN-P2 1% NCK%$SD 2% AGA$3 2% N !2L2 1% A2ML1 2% $%'3CA 2% $RD#4 1% (R4#1 1% (R4N2 1% DAB1 2% ZNF70 2% CES1 2% $DE4C 1% S$&!D1 1% "(*A3 2% GSTCD 1% +ASL 1% 'RTAP26-1 1% NPNT 1% )BA5 2% $HC2 1% ICT1 1% -IN2 1% $&(*1 2% *'&6 1% G$% 1% 'CTD21 1% GCD" 1% ALD"1A3 1% -*(7 1% (R4,3 2% &ALGAPA1 1% #AX 1% )LK3 2% !#&3 1% +FDC3 1% N"$2L1 2% ASA$1 2% '% 15 1% )"& 2 1% NUDT5 2% SLC12A2 1% TNFSF10 1% AM98C 2% $HACTR1 3% LG2 1% SNX29 2% 'LHL7 2% IGSF3 1% &SU1 1% CDK4 1% SLC30A3 2% L#(7 1% CELF3 2% CHSD1 2% TCF12 1% GLOD4 1% ZKSCAN1 1% S%&T4 1% ATP2A1 2% CCDC18 0% #ETTL3 1% !HD4 1% ZNF800 1% SLC9A5 1% GLT8D2 100 25 20 15 10 5 0 80 0.5 2.0 3.5 # mutations 60 -log10(7.8alue) 40 A4494ic 20 fraction 0 100 double_null indel+null 80 transver 60 A->G % *Cp(A/C/T)->T 40 *CpG->T 20 0 '%&C.A3.3382-T$ '%&C.-0.5693-T$ '%&C.A3.3331-T$ '%&C.-0.5699-T$ '%&C.C3-5676-T$ '%&C.C3-5684-T$ '%&C.-0.5399-T$ '%&C.-0.4816-T$ '%&C.-4.5832-T$ '%&C.C3-5679-T$ '%&C.-0.5696-T$ '%&C.C3-4903-T$ '%&C.-0.5085-T$ '%&C.C3-4634-T$ '%&C.-0.5703-T$ '%&C.-0.4706-T$ '%&C.-8.4148-T$ '%&C.-0.5115-T$ '%&C.-8.4154-T$ '%&C.-0.5711-T$ '%&C.-0.5705-T$ '%&C.C3-4912-T$ '%&C.-0.5710-T$ '%&C.C3-4920-T$ '%&C.-4.5836-T$ '%&C.-0.4818-T$ '%&C.-0.5104-T$ '%&C.C3-6030-T$ '%&C.C3-4875-T$ '%&C.-0.5110-T$ '%&C.-0.5116-T$ '%&C.A3.3373-T$ '%&C.C3-4908-T$ '%&C.-0.4712-T$ '%&C.A3.3383-T$ '%&C.C3-4894-T$ '%&C.-0.5402-T$ '%&C.-0.5081-T$ '%&C.-8.4621-T$ '%&C.-0.4710-T$ '%&C.-0.5108-T$ '%&C.-0.5077-T$ '%&C.-0.5106-T$ '%&C.-0.4827-T$ '%&C.-8.4151-T$ '%&C.-0.5097-T$ '%&C.-0.5075-T$ '%&C.C3-5677-T$ '%&C.C3-4644-T$ '%&C.C3-6027-T$ '%&C.-0.4810-T$ '%&C.-0.5691-T$ '%&C.-8.5163-T$ '%&C.-0.5709-T$ '%&C.C3-4637-T$ '%&C.-8.5550-T$ '%&C.-2.3924-T$ '%&C.C3-5675-T$ '%&C.-2.5635-T$ '%&C.-8.5551-T$ '%&C.-0.4847-T$ '%&C.C3-4918-T$ '%&C.-0.5695-T$ '%&C.-0.4945-T$ '%&C.-0.5692-T$ '%&C.-0.5107-T$ '%&C.C3-6033-T$ '%&C.-8.5159-T$ '%&C.-0.5099-T$ '%&C.C3-6032-T$ '%&C.C3-4638-T$ '%&C.-0.4823-T$ '%&C.-8.5549-T$ '%&C.-8.4153-T$ '%&C.C3-4636-T$ '%&C.C3-5672-T$ '%&C.-8.5164-T$ '%&C.C3-5686-T$ '%&C.C3-4900-T$ '%&C.A3.3385-T$ '%&C.-0.5088-T$ '%&C.-4.5843-T$ '%&C.C3-6031-T$ '%&C.-0.5102-T$ '%&C.C3-5680-T$ '%&C.C3-4916-T$ '%&C.-0.5812-T$ '%&C.A3.3349-T$ '%&C.-0.4713-T$ '%&C.-0.4703-T$ '%&C.-0.4833-T$ '%&C.C3-4872-T$ '%&C.-0.4690-T$ '%&C.-0.4714-T$ '%&C.-0.4824-T$ '%&C.C3-4885-T$ '%&C.C3-4884-T$ '%&C.-0.4822-T$ '%&C.-0.4845-T$ '%&C.C3-4892-T$ '%&C.C3-5682-T$ '%&C.A3.3320-T$ '%&C.C3-4905-T$ '%&C.-0.4852-T$ '%&C.C3-5678-T$ '%&C.A3.3311-T$ '%&C.A3.3367-T$ '%&C.C3-4871-T$ '%&C.-0.5698-T$ '%&C.-0.4828-T$ '%&C.-0.5094-T$ '%&C.-0.4718-T$ '%&C.C3-4923-T$ '%&C.C3-4887-T$ '%&C.A3.3387-T$ '%&C.A3.3372-T$ '%&C.-0.4842-T$ '%&C.-0.5713-T$ '%&C.-0.5120-T$ '%&C.-0.4815-T$ '%&C.A3.3362-T$ '%&C.-0.5694-T$ '%&C.-0.5096-T$ '%&C.-0.4849-T$ '%&C.C3-4635-T$ '%&C.-2.4099-T$ '%&C.C3-4913-T$ '%&C.A3.3326-T$ '%&C.-0.5113-T$ '%&C.C3-4888-T$ '%&C.-0.4819-T$ '%&C.-0.5095-T$ '%&C.A3.3308-T$ '%&C.A3.3374-T$ '%&C.A3.3319-T$ '%&C.A3.3378-T$ '%&C.A3.3313-T$ '%&C.A3.3346-T$ '%&C.A3.3365-T$ '%&C.-0.5098-T$ '%&C.A3.3322-T$ '%&C.A3.3363-T$ '%&C.A3.3323-T$ '%&C.C3-4870-T$ '%&C.A3.3380-T$ '%&C.A3.3316-T$ '%&C.C3-4640-T$ '%&C.-0.5092-T$ '%&C.-0.4841-T$ '%&C.-0.4837-T$ '%&C.-8.4620-T$ '%&C.-0.5121-T$ '%&C.-4.5835-T$ '%&C.-8.4622-T$ '%&C.-0.4814-T$ '%&C.-2.4101-T$ '%&C.-0.4811-T$ '%&C.C3-5671-T$ '%&C.C3-4891-T$ '%&C.-0.4694-T$ '%&C.-8.5158-T$ '%&C.-0.4843-T$ '%&C.-2.5641-T$ '%&C.-0.4844-T$ '%&C.-8.4143-T$ '%&C.-0.4691-T$ '%&C.A3.3317-T$ '%&C.C3-4641-T$ '%&C.-0.5117-T$ '%&C.-0.5697-T$ '%&C.-0.5701-T$ '%&C.C3-4907-T$ '%&C.-0.5712-T$ '%&C.-0.5119-T$ '%&C.-4.5844-T$ '%&C.-0.4846-T$ '%&C.A3.3347-T$ '%&C.-0.5100-T$ '%&C.-0.4693-T$ '%&C.C3-4899-T$ '%&C.A3.3358-T$ '%&C.C3-5681-T$ '%&C.C3-5683-T$ '%&C.-8.5162-T$ '%&C.-0.5083-T$ '%&C.C3-4639-T$ '%&C.-8.5546-T$ '%&C.C3-4869-T$ '%&C.-0.5706-T$ '%&C.-2.4098-T$ '%&C.C3-4901-T$ '%&C.-8.5545-T$ '%&C.C3-4889-T$ '%&C.C3-4873-T$ '%&C.C3-4882-T$ '%&C.C3-4902-T$ '%&C.C3-4878-T$ '%&C.-8.5552-T$ '%&C.-8.5553-T$ '%&C.A3.3357-T$ '%&C.C3-4886-T$ '%&C.-0.4817-T$ '%&C.-0.4838-T$ '%&C.-0.4813-T$ '%&C.-0.5080-T$ '%&C.-4.5838-T$ '%&C.-0.5702-T$ '%&C.-4.5834-T$ '%&C.A3.3370-T$ '%&C.C3-4643-T$ '%&C.C3-4874-T$ '%&C.C3-4897-T$ '%&C.-0.4839-T$ '%&C.C3-4881-T$ '%&C.-0.5084-T$ '%&C.C3-4895-T$ '%&C.A3.3376-T$ '%&C.-4.5377-T$ '%&C.C3-6028-T$ '%&C.-0.5109-T$ '%&C.-0.5707-T$ '%&C.C3-4876-T$ '%&C.-0.5400-T$ '%&C.-8.4146-T$ '%&C.-2.5633-T$ '%&C.C3-4893-T$ '%&C.C3-4904-T$ '%&C.-0.4697-T$ '%&C.C3-4868-T$ '%&C.-0.4836-T$ '%&C.-0.4700-T$ '%&C.-8.5165-T$ '%&C.-2.3923-T$ '%&C.-8.4619-T$ '%&C.C3-4890-T$ '%&C.-0.4707-T$ '%&C.-0.4848-T$ '%&C.CZ.5982.T$ '%&C.-$.5169.T$ '%&C.C+-5580.T$ '%&C.CZ.5470.T$ '%&C.-$.5198.T$ '%&C.!).5907.T$ '%&C.-$.4159.T$ '%&C.-$.4988.T$ '%&C.-$.5187.T$ '%&C.-$.5183.T$ '%&C.-$.4164.T$ '%&C.CZ.5460.T$ '%&C.CZ.5465.T$ '%&C.-$.5200.T$ '%&C.-$.4989.T$ '%&C.CZ.5466.T$ '%&C.-$.4964.T$ '%&C.-$.4999.T$ '%&C.-$.4960.T$ '%&C.CZ.4853.T$ '%&C.-$.4341.T$ '%&C.-$.4329.T$ '%&C.-$.4995.T$ '%&C.CZ.5989.T$ '%&C.-$.5180.T$ '%&C.-$.4982.T$ '%&C.A'.3458.T$ '%&C.CZ.5455.T$ '%&C.-$.5184.T$ '%&C.-$.4975.T$ '%&C.A'.3444.T$ '%&C.-$.4968.T$ '%&C.-$.4991.T$ '%&C.-$.4161.T$ '%&C.A'.3455.T$ '%&C.CZ.4861.T$ '%&C.C+-5591.T$ '%&C.-$.5199.T$ '%&C.C+-5581.T$ '%&C.A'.3430.T$ '%&C.-$.5190.T$ '%&C.CZ.5469.T$ '%&C.-$.5174.T$ '%&C.-$.5176.T$ '%&C.-$.5175.T$ '%&C.CZ.5987.T$ '%&C.-$.5001.T$ '%&C.-$.5007.T$ '%&C.-$.4965.T$ '%&C.A'.3451.T$ '%&C.CZ.5457.T$ '%&C.C+-5588.T$ '%&C.CZ.5985.T$ '%&C.-$.4167.T$ '%&C.-$.4977.T$ '%&C.C+-6093.T$ '%&C.-$.5006.T$ '%&C.CZ.5984.T$ '%&C.-$.5008.T$ '%&C.-$.4963.T$ '%&C.-$.4961.T$ '%&C.-$.5192.T$ '%&C.C+-5583.T$ '%&C.C+-6090.T$ '%&C.-$.4976.T$ '%&C.-$.5173.T$ '%&C.-$.4967.T$ '%&C.!).5906.T$ '%&C.-$.4807.T$ '%&C.!).5905.T$ '%&C.-$.5195.T$ '%&C.-$.5196.T$ 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'%&C.-$.4983.T$ '%&C.-$.4790.T$ '%&C.-$.4351.T$ '%&C.D1.5568.T$ '%&C.-$.4326.T$ '%&C.-$.5010.T$ '%&C.-$.4345.T$ '%&C.-$.5202.T$ '%&C.CZ.5467.T$ '%&C.-$.5000.T$ '%&C.CZ.4866.T$ '%&C.-$.4352.T$ '%&C.-$.4163.T$ '%&C.CZ.5452.T$ '%&C.CZ.5463.T$ '%&C.CZ.4865.T$ '%&C.A'.3429.T$ '%&C.CZ.4857.T$ '%&C.-$.4770.T$ '%&C.CZ.5462.T$ '%&C.-$.4338.T$ '%&C.D1.5574.T$ '%&C.-$.4795.T$ '%&C.-$.4801.T$ '%&C.-$.4761.T$ '%&C.-$.4331.T$ '%&C.C+-5589.T$ '%&C.CZ.4862.T$ '%&C.CZ.5468.T$ '%&C.-$.4799.T$ '%&C.-$.4768.T$ '%&C.-$.4160.T$ '%&C.C+-5585.T$ '%&C.-$.4981.T$ '%&C.D1.5565.T$ '%&C.-$.4343.T$ '%&C.CZ.4856.T$ '%&C.A'.3461.T$ '%&C.CZ.4859.T$ '%&C.-$.4782.T$ '%&C.CZ.5453.T$ '%&C.CZ.5451.T$ '%&C.-$.5185.T$ '%&C.A'.3454.T$ '%&C.-$.4787.T$ '%&C.-$.5191.T$ '%&C.-$.4766.T$ '%&C.C+-6087.T$ '%&C.-$.4775.T$ '%&C.CZ.5988.T$ '%&C.-$.4330.T$ '%&C.-$.4346.T$ '%&C.-$.4971.T$ '%&C.-$.4174.T$ '%&C.CZ.4863.T$ '%&C.-$.4756.T$ '%&C.-$.4972.T$ '%&C.-$.4337.T$ '%&C.-$.4781.T$ '%&C.A'.3456.T$ '%&C.-$.4994.T$ '%&C.-$.4760.T$ '%&C.-$.5201.T$ '%&C.-$.4970.T$ '%&C.C+-6097.T$ '%&C.-$.4354.T$ '%&C.-$.4962.T$ '%&C.D1.5575.T$ '%&C.-$.4804.T$ '%&C.-$.4177.T$ '%&C.-$.4797.T$ '%&C.D1.5569.T$ '%&C.-$.4777.T$ '%&C.-$.4173.T$ '%&C.D1.5576.T$ '%&C.-$.4165.T$ '%&C.A'.3450.T$ '%&C.-$.4758.T$ '%&C.-$.4349.T$ '%&C.-$.4803.T$.
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