25 Syn. Frame shift 20 Missense In frame indel Syn. 15 Splice site Other non syn. Non syn. 10 Nonsense 5

# mutations/Mb 0 239 50% VHL 143 31% PBRM1 5% DNMT1 4% KIAA0408 4% CCDC136 4% SMG7 3% CCDC91 3% ARAP3 3% DPP3 3% TAS2R3 3% ACSL3 3% EFNB3 3% NAPSA 3% OSBPL3 3% SPDYE3 2% C1S 2% PKD2 2% SLC26A4 2% TSKS 2% PHYH 2% OR4A47 2% PREP 2% SDHAF2 2% SLC4A5 2% ARPC2 2% CHSY1 2% PDE9A 2% RRAS2 2% TRH 2% NETO2 2% PCGF1 2% RBPJL 2% SHANK1 2% ZMAT2 1% FAP 1% FBXO24 1% NSFL1C 1% NWD1 1% PRB1 1% PXMP2 1% SLC35F1 1% DHRSX 1% ERN2 1% OR9Q1 1% PAX2 1% RASAL1 1% RNF168 1% SNRNP70 1% TATDN2 1% BMP8A 1% CPB2 1% GUF1 1% MPO 53 11% SETD2 4% PTEN 6% KDM5C 5% BAP1 3% TP53 37 7% MTOR 2% SPRY4 2% SORD 2% OR4D1 2% SLC6A7 2% CIB3 3% LETM1 2% NAT8 2% FAM122C 2% EXTL2 2% EGR1 2% MARK4 2% MRPL10 2% PCGF2 79 11% MUC4 2% DCAF11 1% CDC42EP3 2% SLC30A9 1% BMF 2% CECR1 2% CCDC97 1% CPOX 2% CDHR1 2% LETMD1 3% CAMTA2 1% TSPAN19 2% DPEP2 2% ZNF280A 1% NPL 1% EMP2 2% HPS3 2% PLOD3 1% ZNF512 1% TIMP3 1% SLC43A3 2% ZNF625 1% TCEB1 1% LDLRAP1 1% ANKRD23 1% SLC43A1 2% CD4 2% ZDHHC5 2% ANGPTL6 1% IP6K2 2% RBM23 1% IGSF5 2% RPS6KA1 1% YIF1A 1% BRAP 2% NACA 2% AMHR2 1% CRYBB1 1% VPS33A 1% ATP2A3 2% ABCC1 1% GMEB1 1% UBXN7 1% OR4F15 2% DCDC1 1% EMG1 1% TMEM229A 0% OR2A25 1% POLR2F 2% NEFH 1% OR4D11 2% SCN4A 2% TBC1D8B 1% KIAA1919 1% ELOVL5 1% TESK1 1% SEMA4F 2% THBS1 1% PRKAA2 1% SLC18A2 1% PTGER3 3% DNMT3A 1% MTFR1 1% TTF2 1% MKX 1% EDIL3 1% ZADH2 1% TAGLN3 0% C4orf47 1% ASRGL1 2% ATN1 2% ZBTB39 1% OR4K5 2% TMEM145 4% RANBP2 1% NCKIPSD 2% AGAP3 2% NFE2L2 1% A2ML1 2% PIK3CA 2% PRDM4 1% OR4M1 1% OR4N2 1% DAB1 2% ZNF70 2% CES1 2% PDE4C 1% SPRED1 1% HOXA3 2% GSTCD 1% WASL 1% KRTAP26-1 1% NPNT 1% UBA5 2% PHC2 1% ICT1 1% BIN2 1% PROX1 2% XKR6 1% GPI 1% KCTD21 1% GCDH 1% ALDH1A3 1% FBXO7 1% OR4Q3 2% RALGAPA1 1% MAX 1% ULK3 2% EMR3 1% WFDC3 1% NHP2L1 2% ASAP1 2% KIF15 1% UHRF2 1% NUDT5 2% SLC12A2 1% TNFSF10 1% FAM98C 2% PHACTR1 3% FLG2 1% SNX29 2% KLHL7 2% IGSF3 1% RSU1 1% CDK4 1% SLC30A3 2% LMO7 1% CELF3 2% FCHSD1 2% TCF12 1% GLOD4 1% ZKSCAN1 1% SIRT4 1% ATP2A1 2% CCDC18 0% METTL3 1% EHD4 1% ZNF800 1% SLC9A5 1% GLT8D2 100 25 20 15 10 5 0 80 0.5 2.0 3.5 # mutations 60 -log10(q-value) 40 Allelic 20 fraction 0 100 double_null indel+null 80 transver 60 A->G % *Cp(A/C/T)->T 40 *CpG->T 20 0 KIRC-A3-3382-TP KIRC-B0-5693-TP KIRC-A3-3331-TP KIRC-B0-5699-TP KIRC-CJ-5676-TP KIRC-CJ-5684-TP KIRC-B0-5399-TP KIRC-B0-4816-TP KIRC-B4-5832-TP KIRC-CJ-5679-TP KIRC-B0-5696-TP KIRC-CJ-4903-TP KIRC-B0-5085-TP KIRC-CJ-4634-TP KIRC-B0-5703-TP KIRC-B0-4706-TP KIRC-B8-4148-TP KIRC-B0-5115-TP KIRC-B8-4154-TP KIRC-B0-5711-TP KIRC-B0-5705-TP KIRC-CJ-4912-TP KIRC-B0-5710-TP KIRC-CJ-4920-TP KIRC-B4-5836-TP KIRC-B0-4818-TP KIRC-B0-5104-TP KIRC-CJ-6030-TP KIRC-CJ-4875-TP KIRC-B0-5110-TP KIRC-B0-5116-TP KIRC-A3-3373-TP KIRC-CJ-4908-TP KIRC-B0-4712-TP KIRC-A3-3383-TP KIRC-CJ-4894-TP KIRC-B0-5402-TP KIRC-B0-5081-TP KIRC-B8-4621-TP KIRC-B0-4710-TP KIRC-B0-5108-TP KIRC-B0-5077-TP KIRC-B0-5106-TP KIRC-B0-4827-TP KIRC-B8-4151-TP KIRC-B0-5097-TP KIRC-B0-5075-TP KIRC-CJ-5677-TP KIRC-CJ-4644-TP KIRC-CJ-6027-TP KIRC-B0-4810-TP KIRC-B0-5691-TP KIRC-B8-5163-TP KIRC-B0-5709-TP KIRC-CJ-4637-TP KIRC-B8-5550-TP KIRC-B2-3924-TP KIRC-CJ-5675-TP KIRC-B2-5635-TP KIRC-B8-5551-TP KIRC-B0-4847-TP KIRC-CJ-4918-TP KIRC-B0-5695-TP KIRC-B0-4945-TP KIRC-B0-5692-TP KIRC-B0-5107-TP KIRC-CJ-6033-TP KIRC-B8-5159-TP KIRC-B0-5099-TP KIRC-CJ-6032-TP KIRC-CJ-4638-TP KIRC-B0-4823-TP KIRC-B8-5549-TP KIRC-B8-4153-TP KIRC-CJ-4636-TP KIRC-CJ-5672-TP KIRC-B8-5164-TP KIRC-CJ-5686-TP KIRC-CJ-4900-TP KIRC-A3-3385-TP KIRC-B0-5088-TP KIRC-B4-5843-TP KIRC-CJ-6031-TP KIRC-B0-5102-TP KIRC-CJ-5680-TP KIRC-CJ-4916-TP KIRC-B0-5812-TP KIRC-A3-3349-TP KIRC-B0-4713-TP KIRC-B0-4703-TP KIRC-B0-4833-TP KIRC-CJ-4872-TP KIRC-B0-4690-TP KIRC-B0-4714-TP KIRC-B0-4824-TP KIRC-CJ-4885-TP KIRC-CJ-4884-TP KIRC-B0-4822-TP KIRC-B0-4845-TP KIRC-CJ-4892-TP KIRC-CJ-5682-TP KIRC-A3-3320-TP KIRC-CJ-4905-TP KIRC-B0-4852-TP KIRC-CJ-5678-TP KIRC-A3-3311-TP KIRC-A3-3367-TP KIRC-CJ-4871-TP KIRC-B0-5698-TP KIRC-B0-4828-TP KIRC-B0-5094-TP KIRC-B0-4718-TP KIRC-CJ-4923-TP KIRC-CJ-4887-TP KIRC-A3-3387-TP KIRC-A3-3372-TP KIRC-B0-4842-TP KIRC-B0-5713-TP KIRC-B0-5120-TP KIRC-B0-4815-TP KIRC-A3-3362-TP KIRC-B0-5694-TP KIRC-B0-5096-TP KIRC-B0-4849-TP KIRC-CJ-4635-TP KIRC-B2-4099-TP KIRC-CJ-4913-TP KIRC-A3-3326-TP KIRC-B0-5113-TP KIRC-CJ-4888-TP KIRC-B0-4819-TP KIRC-B0-5095-TP KIRC-A3-3308-TP KIRC-A3-3374-TP KIRC-A3-3319-TP KIRC-A3-3378-TP KIRC-A3-3313-TP KIRC-A3-3346-TP KIRC-A3-3365-TP KIRC-B0-5098-TP KIRC-A3-3322-TP KIRC-A3-3363-TP KIRC-A3-3323-TP KIRC-CJ-4870-TP KIRC-A3-3380-TP KIRC-A3-3316-TP KIRC-CJ-4640-TP KIRC-B0-5092-TP KIRC-B0-4841-TP KIRC-B0-4837-TP KIRC-B8-4620-TP KIRC-B0-5121-TP KIRC-B4-5835-TP KIRC-B8-4622-TP KIRC-B0-4814-TP KIRC-B2-4101-TP KIRC-B0-4811-TP KIRC-CJ-5671-TP KIRC-CJ-4891-TP KIRC-B0-4694-TP KIRC-B8-5158-TP KIRC-B0-4843-TP KIRC-B2-5641-TP KIRC-B0-4844-TP KIRC-B8-4143-TP KIRC-B0-4691-TP KIRC-A3-3317-TP KIRC-CJ-4641-TP KIRC-B0-5117-TP KIRC-B0-5697-TP KIRC-B0-5701-TP KIRC-CJ-4907-TP KIRC-B0-5712-TP KIRC-B0-5119-TP KIRC-B4-5844-TP KIRC-B0-4846-TP KIRC-A3-3347-TP KIRC-B0-5100-TP KIRC-B0-4693-TP KIRC-CJ-4899-TP KIRC-A3-3358-TP KIRC-CJ-5681-TP KIRC-CJ-5683-TP KIRC-B8-5162-TP KIRC-B0-5083-TP KIRC-CJ-4639-TP KIRC-B8-5546-TP KIRC-CJ-4869-TP KIRC-B0-5706-TP KIRC-B2-4098-TP KIRC-CJ-4901-TP KIRC-B8-5545-TP KIRC-CJ-4889-TP KIRC-CJ-4873-TP KIRC-CJ-4882-TP KIRC-CJ-4902-TP KIRC-CJ-4878-TP KIRC-B8-5552-TP KIRC-B8-5553-TP KIRC-A3-3357-TP KIRC-CJ-4886-TP KIRC-B0-4817-TP KIRC-B0-4838-TP KIRC-B0-4813-TP KIRC-B0-5080-TP KIRC-B4-5838-TP KIRC-B0-5702-TP KIRC-B4-5834-TP KIRC-A3-3370-TP KIRC-CJ-4643-TP KIRC-CJ-4874-TP KIRC-CJ-4897-TP KIRC-B0-4839-TP KIRC-CJ-4881-TP KIRC-B0-5084-TP KIRC-CJ-4895-TP KIRC-A3-3376-TP KIRC-B4-5377-TP KIRC-CJ-6028-TP KIRC-B0-5109-TP KIRC-B0-5707-TP KIRC-CJ-4876-TP KIRC-B0-5400-TP KIRC-B8-4146-TP KIRC-B2-5633-TP KIRC-CJ-4893-TP KIRC-CJ-4904-TP KIRC-B0-4697-TP KIRC-CJ-4868-TP KIRC-B0-4836-TP KIRC-B0-4700-TP KIRC-B8-5165-TP KIRC-B2-3923-TP KIRC-B8-4619-TP KIRC-CJ-4890-TP KIRC-B0-4707-TP KIRC-B0-4848-TP KIRC-CZ-5982-TP KIRC-BP-5169-TP KIRC-CW-5580-TP KIRC-CZ-5470-TP KIRC-BP-5198-TP KIRC-EU-5907-TP KIRC-BP-4159-TP KIRC-BP-4988-TP KIRC-BP-5187-TP KIRC-BP-5183-TP KIRC-BP-4164-TP KIRC-CZ-5460-TP KIRC-CZ-5465-TP KIRC-BP-5200-TP KIRC-BP-4989-TP KIRC-CZ-5466-TP KIRC-BP-4964-TP KIRC-BP-4999-TP KIRC-BP-4960-TP KIRC-CZ-4853-TP KIRC-BP-4341-TP KIRC-BP-4329-TP KIRC-BP-4995-TP KIRC-CZ-5989-TP KIRC-BP-5180-TP KIRC-BP-4982-TP KIRC-AK-3458-TP KIRC-CZ-5455-TP KIRC-BP-5184-TP KIRC-BP-4975-TP KIRC-AK-3444-TP KIRC-BP-4968-TP KIRC-BP-4991-TP KIRC-BP-4161-TP KIRC-AK-3455-TP KIRC-CZ-4861-TP KIRC-CW-5591-TP KIRC-BP-5199-TP KIRC-CW-5581-TP KIRC-AK-3430-TP KIRC-BP-5190-TP KIRC-CZ-5469-TP KIRC-BP-5174-TP KIRC-BP-5176-TP KIRC-BP-5175-TP KIRC-CZ-5987-TP KIRC-BP-5001-TP KIRC-BP-5007-TP KIRC-BP-4965-TP KIRC-AK-3451-TP KIRC-CZ-5457-TP KIRC-CW-5588-TP KIRC-CZ-5985-TP KIRC-BP-4167-TP KIRC-BP-4977-TP KIRC-CW-6093-TP KIRC-BP-5006-TP KIRC-CZ-5984-TP KIRC-BP-5008-TP KIRC-BP-4963-TP KIRC-BP-4961-TP KIRC-BP-5192-TP KIRC-CW-5583-TP KIRC-CW-6090-TP KIRC-BP-4976-TP KIRC-BP-5173-TP KIRC-BP-4967-TP KIRC-EU-5906-TP KIRC-BP-4807-TP KIRC-EU-5905-TP KIRC-BP-5195-TP KIRC-BP-5196-TP KIRC-BP-5004-TP KIRC-BP-5009-TP KIRC-BP-4162-TP KIRC-BP-4986-TP KIRC-BP-4992-TP KIRC-BP-5177-TP KIRC-EU-5904-TP KIRC-BP-4998-TP KIRC-BP-4771-TP KIRC-CZ-5458-TP KIRC-BP-4974-TP KIRC-BP-5194-TP KIRC-CZ-4858-TP KIRC-BP-4355-TP KIRC-BP-4765-TP KIRC-AK-3445-TP KIRC-BP-4798-TP KIRC-BP-4789-TP KIRC-BP-4166-TP KIRC-BP-4762-TP KIRC-BP-4340-TP KIRC-BP-4759-TP KIRC-BP-4763-TP KIRC-BP-4342-TP KIRC-CZ-5986-TP KIRC-BP-4176-TP KIRC-CZ-5456-TP KIRC-AK-3431-TP KIRC-BP-4774-TP KIRC-BP-5189-TP KIRC-AK-3434-TP KIRC-AK-3436-TP KIRC-BP-4985-TP KIRC-BP-4993-TP KIRC-BP-5168-TP KIRC-BP-5181-TP KIRC-AK-3460-TP KIRC-AK-3425-TP KIRC-CZ-4854-TP KIRC-BP-4158-TP KIRC-DV-5566-TP KIRC-BP-5170-TP KIRC-BP-5186-TP KIRC-BP-4973-TP KIRC-BP-4987-TP KIRC-CZ-5454-TP KIRC-AK-3447-TP KIRC-AK-3443-TP KIRC-AK-3453-TP KIRC-AS-3777-TP KIRC-AK-3427-TP KIRC-AS-3778-TP KIRC-AK-3440-TP KIRC-BP-4347-TP KIRC-BP-5182-TP KIRC-AK-3465-TP KIRC-AK-3428-TP KIRC-BP-4169-TP KIRC-BP-4170-TP KIRC-CZ-5459-TP KIRC-C