25 Syn. Frame shift 20 Missense In frame indel Syn. 15 Splice site Other non syn. Non syn. 10 Nonsense 5

# mutations/Mb 0 243 29% VHL 51 5% TP53 63 4% MUC6 3% MET 3% DNMT1 3% KIAA0408 2% CCDC136 2% SMG7 2% AR 2% ARAP3 2% CCDC91 2% DPP3 2% PCF11 2% ZNF814 2% NAPSA 2% TAS2R3 2% ACSL3 2% EFNB3 2% OSBPL3 2% SPDYE3 2% TSKS 1% C1S 1% ABCC1 1% PHYH 1% CHSY1 1% OR4A47 1% SDHAF2 1% ARPC2 1% RRAS2 1% TRH 1% EXTL2 1% RBPJL 1% ZMAT2 1% FAP 1% PRB1 1% PXMP2 1% OR9Q1 1% PAX2 1% SNRNP70 1% TATDN2 0% MTG1 155 19% PBRM1 4% PTEN 73 9% SETD2 4% BAP1 4% KDM5C 2% NEFH 226 13% MUC4 2% NF2 2% NFE2L2 1% NAT8 2% PKD2 2% FRG1 1% SPRY4 1% TCEB1 1% SORD 1% CIB3 1% KDELR3 1% OR4D1 2% CUL3 1% PCGF1 1% KRAS 1% PCGF2 1% SLC6A7 1% FAM122C 2% LETM1 1% CDC42EP3 1% PARD6B 1% BMF 5% MTOR 1% MARK4 1% EGR1 2% PIK3CA 1% NSFL1C 1% LETMD1 1% SLC35F1 1% DHRSX 1% PREP 1% IL32 1% CPOX 1% EMP2 1% NETO2 1% MRPL10 1% PDE9A 2% SLC26A4 1% TIMP3 1% DCAF11 1% CCDC97 1% TSPAN19 1% EDIL3 2% THBS1 1% LDLRAP1 1% TAS2R43 1% ZNF512 1% SLC30A9 1% HPS3 2% CAMTA2 1% ACSF2 1% BMP8A 2% DNMT3A 1% DPEP2 1% TXNIP 1% CECR1 2% SLC4A5 1% ZNF625 1% SAV1 1% PRSS3 1% CDHR1 3% SMARCA4 1% KRTAP4-5 1% SMARCB1 2% STAG2 1% UBXN7 1% RASAL1 1% FAM20C 1% OR4D11 0% OR2A25 1% WASL 1% NACA 1% VPS33A 1% UHRF2 1% PCDHGC4 2% PLOD3 1% REM1 1% RBM23 1% YIF1A 1% ANGPTL6 1% RIMBP3 1% EMG1 1% SHANK1 1% AQP7 1% ALDH1A3 1% ATN1 1% DCDC1 1% OR4M1 1% ZNF280A 1% SLC43A3 1% FBXO24 1% CRYBB1 1% RHEB 1% SCN4A 1% NPL 1% PRB4 1% ZDHHC5 1% RPS6KA1 1% PRKAA2 1% RSU1 1% LMO4 1% ATP1B1 1% OR4N2 1% OR5V1 0% C4orf47 2% MAGEC1 1% CD4 1% AMHR2 1% GLS 4% MUC2 1% NDUFAF3 1% NASP 0% TAGLN3 1% KLHL7 1% NWD1 1% RNF168 1% ZADH2 2% CAD 1% IGDCC4 0% MKX 0% RPL22 1% RIMBP3B 1% RTKN 1% MPO 1% VCX3B 1% PCSK5 1% KRTAP4-11 1% KCNK5 1% ASRGL1 1% MRGPRX3 1% OTOL1 1% DPAGT1 1% ELOVL5 1% PHACTR1 100 50 40 30 20 10 0 80 0.5 2.0 3.5 # mutations 60 -log10(q-value) 40 Allelic 20 fraction 0 100 double_null indel+null 80 transver 60 A->G % *Cp(A/C/T)->T 40 *CpG->T 20 0 KIRP-IZ-8196-TP KIRP-2Z-A9JI-TP KIRP-J7-A8I2-TP KIRP-IZ-8195-TP KIRC-AS-3778-TP KIRC-A3-3383-TP KIRC-B0-4710-TP KIRC-CJ-5677-TP KIRC-B0-4712-TP KIRC-A3-3382-TP KIRC-EU-5907-TP KIRC-AK-3444-TP KIRC-A3-3316-TP KIRC-A3-3372-TP KIRC-A3-3308-TP KIRC-A3-3378-TP KIRC-CZ-5982-TP KIRC-B8-5159-TP KIRC-B0-5693-TP KIRC-BP-5184-TP KIRC-CJ-5675-TP KIRC-BP-5196-TP KIRC-BP-4968-TP KIRC-B0-5699-TP KIRC-BP-5169-TP KIRC-CJ-5684-TP KIRC-BP-5198-TP KIRC-CJ-5676-TP KIRC-CZ-5470-TP KIRC-B0-5399-TP KIRC-A3-3331-TP KIRC-BP-4159-TP KIRC-B0-4816-TP KIRC-B0-4706-TP KIRC-BP-5187-TP KIRC-B0-5703-TP KIRC-BP-5183-TP KIRC-BP-4164-TP KIRC-CZ-5460-TP KIRC-B8-4148-TP KIRC-CJ-4634-TP KIRC-CJ-4903-TP KIRC-B0-5085-TP KIRC-BP-4988-TP KIRC-B4-5836-TP KIRC-B4-5832-TP KIRC-CJ-5679-TP KIRC-B0-5696-TP KIRC-BP-4960-TP KIRC-CZ-5465-TP KIRC-BP-4989-TP KIRC-B0-5115-TP KIRC-BP-5200-TP KIRC-BP-5181-TP KIRC-BP-4999-TP KIRC-B8-4154-TP KIRC-B0-5705-TP KIRC-BP-4964-TP KIRC-CJ-6030-TP KIRC-CZ-5466-TP KIRC-CJ-4920-TP KIRC-B0-5711-TP KIRC-CJ-4912-TP KIRC-B0-5710-TP KIRC-B0-5116-TP KIRC-BP-4982-TP KIRC-CJ-4875-TP KIRC-CZ-4853-TP KIRC-B0-4818-TP KIRC-B0-5110-TP KIRC-B0-5104-TP KIRC-BP-4341-TP KIRC-BP-4329-TP KIRC-A3-3373-TP KIRC-BP-4995-TP KIRC-CZ-5989-TP KIRC-BP-5180-TP KIRC-AK-3458-TP KIRC-CZ-5455-TP KIRC-CJ-4908-TP KIRC-BP-4975-TP KIRC-B8-4621-TP KIRC-BP-5199-TP KIRC-BP-4161-TP KIRC-AK-3455-TP KIRC-CZ-4861-TP KIRC-B0-5402-TP KIRC-B0-5081-TP KIRC-B8-4151-TP KIRC-CZ-5469-TP KIRC-B0-5097-TP KIRC-B0-4827-TP KIRP-AL-3473-TP KIRC-B0-5075-TP KIRC-BP-5174-TP KIRC-AK-3430-TP KIRC-B0-5108-TP KIRC-B0-5106-TP KIRC-B0-5077-TP KIRC-BP-5190-TP KIRC-AK-3451-TP KIRC-B8-5163-TP KIRC-CZ-5457-TP KIRC-CJ-4644-TP KICH-KN-8432-TP KIRC-B0-5709-TP KIRC-CJ-4637-TP KIRC-B8-5551-TP KIRC-B8-5550-TP KIRC-B8-5162-TP KIRC-B2-3924-TP KIRC-B2-5635-TP KIRC-CZ-5985-TP KIRC-BP-4167-TP KIRC-B0-4847-TP KIRC-B8-4153-TP KIRC-BP-4965-TP KIRC-CZ-5984-TP KIRC-BP-5175-TP KIRC-BP-4963-TP KIRC-BP-5007-TP KIRC-B0-4810-TP KIRC-CJ-6027-TP KIRC-B0-5691-TP KIRC-BP-5176-TP KIRC-CZ-5987-TP KIRC-BP-5001-TP KIRC-CJ-6033-TP KIRP-BQ-5892-TP KIRC-CJ-4894-TP KIRC-BP-4977-TP KIRC-CJ-4918-TP KIRC-BP-4992-TP KIRC-B0-4823-TP KIRC-CJ-4916-TP KIRC-BP-5006-TP KIRC-BP-4998-TP KIRC-B0-4945-TP KIRC-CJ-5686-TP KIRC-EU-5904-TP KIRC-BP-4986-TP KIRC-BP-4991-TP KIRC-BP-5192-TP KIRC-BP-4976-TP KIRC-CJ-5672-TP KIRC-BP-5173-TP KIRC-B8-5164-TP KIRC-B8-5549-TP KIRC-BP-4967-TP KIRC-B0-5695-TP KIRC-B0-5692-TP KIRC-CJ-4638-TP KIRC-CJ-4900-TP KIRC-B0-5099-TP KIRC-A3-3385-TP KIRC-EU-5906-TP KIRC-BP-4807-TP KIRC-EU-5905-TP KIRC-B0-5107-TP KIRC-BP-5195-TP KIRC-B0-5088-TP KIRC-CJ-4636-TP KIRC-B4-5843-TP KIRC-CJ-6031-TP KIRC-B0-5102-TP KIRC-CJ-5680-TP KIRC-BP-5004-TP KIRC-CJ-6032-TP KIRC-BP-5009-TP KIRC-BP-4162-TP KIRC-BP-5177-TP KIRC-B0-5812-TP KIRC-BP-4961-TP KIRC-A3-3349-TP KIRC-BP-5008-TP KIRC-BP-4771-TP KIRC-CZ-5458-TP KIRC-BP-4974-TP KIRC-BP-5194-TP KIRC-CZ-4858-TP KIRC-BP-4355-TP KIRC-BP-4765-TP KIRC-B0-4713-TP KIRC-AK-3445-TP KIRC-B0-4703-TP KIRC-BP-4166-TP KIRC-BP-4798-TP KIRC-B0-4833-TP KIRC-BP-4789-TP KIRC-CJ-4872-TP KIRC-CJ-4884-TP KIRC-CJ-4885-TP KIRC-B0-4690-TP KIRC-BP-4762-TP KIRC-B0-4824-TP KIRC-B0-4714-TP KIRC-B0-4822-TP KIRC-CJ-4892-TP KIRC-B0-4845-TP KIRC-BP-4763-TP KIRC-BP-4340-TP KIRC-BP-4759-TP KIRC-BP-4342-TP KIRC-B0-5098-TP KICH-KO-8414-TP KICH-KL-8329-TP KICH-KN-8434-TP KICH-KO-8403-TP KICH-KN-8431-TP KICH-KN-8436-TP KIRC-CZ-5463-TP KICH-KO-8416-TP KIRC-A3-3313-TP KICH-KN-8428-TP KIRC-AK-3440-TP KIRC-A3-3363-TP KIRC-A3-3346-TP KIRP-A4-A57E-TP KIRC-BP-4176-TP KIRP-5P-A9K3-TP KICH-KL-8336-TP KICH-KO-8408-TP KICH-KL-8337-TP KICH-KO-8413-TP KICH-KL-8339-TP KICH-KL-8341-TP KICH-KN-8424-TP KICH-KN-8418-TP KICH-KL-8338-TP KIRP-BQ-5881-TP KIRP-B1-A655-TP KIRP-BQ-5893-TP KICH-KL-8324-TP KIRP-B3-4104-TP KICH-KN-8423-TP KIRC-CZ-4865-TP KIRC-B0-5117-TP KICH-KN-8430-TP KIRC-B0-5096-TP KIRC-AK-3425-TP KICH-KO-8415-TP KIRP-P4-A5E7-TP KICH-KM-8438-TP KICH-KN-8433-TP KICH-KO-8409-TP KICH-KN-8427-TP KICH-KL-8325-TP KICH-KN-8421-TP KICH-KN-8435-TP KICH-KL-8330-TP KICH-KN-8429-TP KICH-KO-8410-TP KIRP-B9-A8YI-TP KICH-KO-8411-TP KICH-KL-8334-TP KIRC-A3-3380-TP KIRP-IA-A83W-TP KIRP-UZ-A9PJ-TP KIRP-G7-A8LE-TP KIRP-5P-A9KA-TP KIRP-AL-7173-TP KIRP-BQ-7059-TP KIRP-DZ-6132-TP KIRP-B1-7332-TP KIRP-BQ-5882-TP KIRP-SX-A71S-TP KIRP-A4-7997-TP KIRP-AL-3472-TP KIRP-A4-7734-TP KIRC-B0-5707-TP KIRP-IA-A40U-TP KIRP-DZ-6135-TP KIRC-AK-3453-TP KIRC-A3-3374-TP KIRC-A3-3319-TP KIRC-AK-3427-TP KIRC-AK-3465-TP KIRC-AK-3447-TP KIRC-A3-3320-TP KIRC-CJ-5682-TP KIRC-B0-4819-TP KIRC-A3-3322-TP KIRC-CZ-5986-TP KIRC-B0-5095-TP KIRP-G7-7502-TP KIRC-AS-3777-TP KIRC-AK-3443-TP KIRC-A3-3365-TP KICH-KL-8332-TP KIRP-V9-A7HT-TP KIRP-5P-A9JZ-TP KICH-KL-8344-TP KIRP-2Z-A9J3-TP KIRP-B1-A656-TP KIRP-A4-A5Y0-TP KIRP-UZ-A9PL-TP KIRP-IA-A83T-TP KIRP-2Z-A9JO-TP KIRP-Y8-A8S0-TP KIRC-A3-3323-TP KIRC-CJ-4870-TP KIRP-BQ-7058-TP KIRP-PJ-A8JU-TP KIRP-EV-5903-TP KIRC-B0-5100-TP KIRP-DZ-6134-TP KIRP-BQ-5876-TP KIRP-B1-5398-TP KIRP-BQ-7050-TP KIRP-B9-4617-TP K KIRC-CW-5580-TP KIRC-CW-5591-TP KIRC-CW-5581-TP KIRC-CW-5588-TP KIRC-CW-6090-TP KIRC-CW-6093-TP KIRP-WN-A9G9-TP KIRC-CW-5583-TP KIRP-5P-A9KH-TP KIRP-MH-A561-TP KIRC-CW-6087-TP KIRP-4A-A93W-TP KIRP-GL-A59R-TP KIRP-SX-A7SQ-TP KIRP-HE-A5NH-TP KIRP-GL-A9DE-TP KIRP-5P-A9KC-TP KIRP-SX-A71U-TP KIRP-G7-A8LD-TP KIRP-GL-A9DC-TP KIRP-5P-A9JW-TP KIRP-UZ-A9Q1-TP KIRP-DW-7840-TP KIRP-GL-A4EM-TP KIRP-KV-A6GE-TP KIRP-UZ-A9PR-TP KIRP-G7-A4TM-TP KIRP-SX-A7SM-TP KIRP-UZ-A9PK-TP KIRC-CW-6097-TP KIRP-MH-A560-TP KIRP-HE-A5NL-TP KIRP-B9-A5W8-TP KIRP-UZ-A9PS-TP KIRP-A4-A6HP-TP KIRP-B1-A47M-TP KIRP-UZ-A9PZ-TP KIRP-SX-A7SU-TP KIRP-MH-A854-TP KIRP-MH-A857-TP KIRP-DW-7841-TP KIRP-DW-7836-TP KIRP-SX-A7SR-TP KIRP-MH-A55Z-TP KIRP-MH-A562-TP KIRC-CW-5589-TP KIRP-HE-A5NK-TP KIRP-G7-A8LC-TP KIRP-UZ-A9Q0-TP KIRP-SX-A71R-TP KIRP-B9-A8YH-TP KIRP-2K-A9WE-TP KIRP-UZ-A9PP-TP KIRP-UZ-A9PV-TP KIRP-B9-A5W7-TP KIRP-Q2-A5QZ-TP KIRP-WN-AB4C-TP KIRP-DW-7963-TP KIRP-MH-A55W-TP KIRP-SX-A7SS-TP KIRP-UZ-A9PX-TP KIRP-SX-A7SN-TP KIRP-GL-A9DD-TP KIRP-DW-7838-TP KIRP-UZ-A9PO-TP KIRP-HE-A5NF-TP KIRP-SX-A7SP-TP KIRP-HE-A5NJ-TP KIRP-AT-A5NU-TP KIRP-Y8-A8RY-TP KIRP-MH-A856-TP KIRP-KV-A6GD-TP KIRP-UZ-A9PU-TP KIRP-P4-AAVM-TP KIRP-DW-7834-TP KIRP-UZ-A9PN-TP KIRC-CW-5585-TP KIRP-UZ-A9PM-TP KIRP-SX-A7SO-TP KIRP-DW-7839-TP KIRP-DW-5561-TP KIRP-DW-7837-TP KIRP-B9-A5W9-TP KIRP-A4-A5DU-TP KIRP-DW-7842-TP KIRP-B3-A6W5-TP KIRP-SX-A71W-TP KIRP-MH-A855-TP KIRP-DW-5560-TP KIRP-UN-AAZ9-TP KIRP-P4-A5ED-TP