Royal Decree on Control of Export Armaments and War Materials out of the Kingdom (No
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Transport of Dangerous Goods
ST/SG/AC.10/1/Rev.16 (Vol.I) Recommendations on the TRANSPORT OF DANGEROUS GOODS Model Regulations Volume I Sixteenth revised edition UNITED NATIONS New York and Geneva, 2009 NOTE The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. ST/SG/AC.10/1/Rev.16 (Vol.I) Copyright © United Nations, 2009 All rights reserved. No part of this publication may, for sales purposes, be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying or otherwise, without prior permission in writing from the United Nations. UNITED NATIONS Sales No. E.09.VIII.2 ISBN 978-92-1-139136-7 (complete set of two volumes) ISSN 1014-5753 Volumes I and II not to be sold separately FOREWORD The Recommendations on the Transport of Dangerous Goods are addressed to governments and to the international organizations concerned with safety in the transport of dangerous goods. The first version, prepared by the United Nations Economic and Social Council's Committee of Experts on the Transport of Dangerous Goods, was published in 1956 (ST/ECA/43-E/CN.2/170). In response to developments in technology and the changing needs of users, they have been regularly amended and updated at succeeding sessions of the Committee of Experts pursuant to Resolution 645 G (XXIII) of 26 April 1957 of the Economic and Social Council and subsequent resolutions. -
Aldrich Vapor
Aldrich Vapor Library Listing – 6,611 spectra This library is an ideal tool for investigator using FT-IR to analyze gas phase materials. It contains gas phase spectra collected by Aldrich using a GC-IR interface to ensure chromatographically pure samples. The Aldrich FT-IR Vapor Phase Library contains 6,611 gas phase FT-IR spectra collected by Aldrich Chemical Company using a GC interface. The library includes compound name, molecular formula, CAS (Chemical Abstract Service) registry number, Aldrich catalog number, and page number in the Aldrich Library of FT-IR Spectra, Edition 1, Volume 3, Vapor-Phase. Aldrich Vapor Index Compound Name Index Compound Name 6417 ((1- 3495 (1,2-Dibromoethyl)benzene; Styrene Ethoxycyclopropyl)oxy)trimethylsilane dibromide 2081 (+)-3-(Heptafluorobutyryl)camphor 3494 (1-Bromoethyl)benzene; 1-Phenylethyl 2080 (+)-3-(Trifluoroacetyl)camphor bromide 262 (+)-Camphene; 2,2-Dimethyl-3- 6410 (1-Hydroxyallyl)trimethylsilane methylenebicyclo[2.2.1]heptane 6605 (1-Methyl-2,4-cyclopentadien-1- 2828 (+)-Diisopropyl L-tartrate yl)manganese tricarbonyl 947 (+)-Isomenthol; [1S-(1a,2b,5b)]-2- 6250 (1-Propynyl)benzene; 1-Phenylpropyne Isopropyl-5-methylcyclohexano 2079 (1R)-(+)-3-Bromocamphor, endo- 1230 (+)-Limonene oxide, cis + trans; (+)-1,2- 2077 (1R)-(+)-Camphor; (1R)-(+)-1,7,7- Epoxy-4-isopropenyl-1- Trimethylbicyclo[2.2.1]heptan- 317 (+)-Longifolene; (1S)-8-Methylene- 976 (1R)-(+)-Fenchyl alcohol, endo- 3,3,7-trimethyltricyclo[5.4.0 2074 (1R)-(+)-Nopinone; (1R)-(+)-6,6- 949 (+)-Menthol; [1S-(1a,2b,5a)]-(+)-2- Dimethylbicyclo[3.1.1]heptan-2- -
Copyrighted Material
1 Historical Milieu 1.1 Organophosphorus Nerve Agents 2 1.2 Blister Agents 5 1.3 Sternutator Agents 11 1.4 Chemical Weapons Convention (CWC) 13 1.4.1 Schedule of Chemicals 14 1.4.2 Destruction of Chemical Weapons 14 References 16 COPYRIGHTED MATERIAL Analysis of Chemical Warfare Degradation Products, First Edition. Karolin K. Kroening, Renee N. Easter, Douglas D. Richardson, Stuart A. Willison and Joseph A. Caruso. © 2011 John Wiley & Sons, Ltd. Published 2011 by John Wiley & Sons, Ltd. 2 ANALYSIS OF CHEMICAL WARFARE DEGRADATION PRODUCTS 1.1 ORGANOPHOSPHORUS NERVE AGENTS Organophosphorus (OP) type compounds, that is, deriva- tives containing the P=O moiety, were first discovered in the 1800s when researchers were investigating useful applica- tions for insecticides/rodenticides. There are many derivatives of organophosphorus compounds, however, the OP deriva- tives that are typically known as ‘nerve agents’ were discov- ered accidentally in Germany in 1936 by a research team led by Dr. Gerhard Schrader at IG Farben [1–4]. Schrader had noticed the effects and lethality of these organophosphorus compounds towards insects and began developing a new class of insecticides. While working towards the goal of an improved insecticide, Schrader experimented with numerous phosphorus-containing compounds, leading to the discovery of the first nerve agent, Tabun (or GA) (Figure 1.1). The potency of these insecticides towards humans was not realized until there was yet another accident, which involved a Tabun spill. Schrader and coworkers began experiencing symptoms, such as miosis (constriction of the pupils of the eyes), dizziness and severe shortness of breath, with numerous effects lasting several weeks [1, 4, 5]. -
Warfare Agents for Modeling Airborne Dispersion in and Around Buildings
LBNL-45475 ERNEST ORLANDO LAWRENCE BERKELEY NATIn NAL LABORATORY Databaseof Physical,Chemicaland ToxicologicalPropertiesof Chemical and Biological(CB)WarfitreAgentsfor ModelingAirborneDispersionIn and AroundBuildings TracyThatcher,RichSextro,andDonErmak Environmental Energy Technologies Division DISCLAIMER This document was prepared as an account of work sponsored by the United States Government. While this document is believed to contain correct information, neither the United States Government nor any agency thereof, nor The Regents of the University of Catifomia, nor any of their employees, makes any warranty, express or implied, or assumes any legal responsibility for the accuracy, completeness, or usefulness of anY information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by its trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommend at i on, or favoring by the United States Government or any agency thereof, or The Regents of the University of California. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof, or The Regents of the University of California. Ernest Orlando Lawrence Berkeley National Laboratory is an equal opportunity employer. DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced -
Aldrich Raman
Aldrich Raman Library Listing – 14,033 spectra This library represents the most comprehensive collection of FT-Raman spectral references available. It contains many common chemicals found in the Aldrich Handbook of Fine Chemicals. To create the Aldrich Raman Condensed Phase Library, 14,033 compounds found in the Aldrich Collection of FT-IR Spectra Edition II Library were excited with an Nd:YVO4 laser (1064 nm) using laser powers between 400 - 600 mW, measured at the sample. A Thermo FT-Raman spectrometer (with a Ge detector) was used to collect the Raman spectra. The spectra were saved in Raman Shift format. Aldrich Raman Index Compound Name Index Compound Name 4803 ((1R)-(ENDO,ANTI))-(+)-3- 4246 (+)-3-ISOPROPYL-7A- BROMOCAMPHOR-8- SULFONIC METHYLTETRAHYDRO- ACID, AMMONIUM SALT PYRROLO(2,1-B)OXAZOL-5(6H)- 2207 ((1R)-ENDO)-(+)-3- ONE, BROMOCAMPHOR, 98% 12568 (+)-4-CHOLESTEN-3-ONE, 98% 4804 ((1S)-(ENDO,ANTI))-(-)-3- 3774 (+)-5,6-O-CYCLOHEXYLIDENE-L- BROMOCAMPHOR-8- SULFONIC ASCORBIC ACID, 98% ACID, AMMONIUM SALT 11632 (+)-5-BROMO-2'-DEOXYURIDINE, 2208 ((1S)-ENDO)-(-)-3- 97% BROMOCAMPHOR, 98% 11634 (+)-5-FLUORODEOXYURIDINE, 769 ((1S)-ENDO)-(-)-BORNEOL, 99% 98+% 13454 ((2S,3S)-(+)- 11633 (+)-5-IODO-2'-DEOXYURIDINE, 98% BIS(DIPHENYLPHOSPHINO)- 4228 (+)-6-AMINOPENICILLANIC ACID, BUTANE)(N3-ALLYL)PD(II) CL04, 96% 97 8167 (+)-6-METHOXY-ALPHA-METHYL- 10297 ((3- 2- NAPHTHALENEACETIC ACID, DIMETHYLAMINO)PROPYL)TRIPH 98% ENYL- PHOSPHONIUM BROMIDE, 12586 (+)-ANDROSTA-1,4-DIENE-3,17- 99% DIONE, 98% 13458 ((R)-(+)-2,2'- 963 (+)-ARABINOGALACTAN BIS(DIPHENYLPHOSPHINO)-1,1'- -
C-Metalated Nitriles: Diastereoselective Alkylations and Arylations
Duquesne University Duquesne Scholarship Collection Electronic Theses and Dissertations Fall 12-20-2019 C-Metalated Nitriles: Diastereoselective Alkylations and Arylations Robert John Mycka Duquesne University Follow this and additional works at: https://dsc.duq.edu/etd Part of the Organic Chemistry Commons Recommended Citation Mycka, R. J. (2019). C-Metalated Nitriles: Diastereoselective Alkylations and Arylations (Doctoral dissertation, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1851 This Immediate Access is brought to you for free and open access by Duquesne Scholarship Collection. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of Duquesne Scholarship Collection. C-METALATED NITRILES: DIASTEREOSELECTIVE ALKYLATIONS AND ARYLATIONS A Dissertation Submitted to the Bayer School of Natural and Environmental Sciences Duquesne University In partial fulfillment of the requirements for the degree of Doctor of Philosophy By Robert J. Mycka December 2019 Copyright by Robert J. Mycka 2019 C-METALATED NITRILES: DIASTEREOSELECTIVE ALKYLATIONS AND ARYLATIONS By Robert J. Mycka Approved November 13, 2019 ________________________________ ________________________________ Dr. Bruce D. Beaver Dr. Jeffrey D. Evanseck Professor of Chemistry and Biochemistry Professor of Chemistry and Biochemistry (Committee Chair) (Committee Member) ________________________________ ________________________________ Dr. Shahed U. M. Khan Dr. Patrick T. Flaherty Associate Professor of Chemistry and -
Chemical, Radiological and Nuclear Medical Countermeasures
Chemical, Radiological and Nuclear Medical Countermeasures Ron Manning,g, Ph.D. Chief, Chemical, Radiological and Nuclear Division of CBRN Countermeasures June 7, 2011 Roadmap • Rad Nuc Background and the threat • Rad Nuc Scenario considerations and Reqquirements development • Areas of Rad Nuc Programmatic Interest • Rad Nuc Portfolio Strategy • Special Considerations for Development Efforts • Solicitations in Fed Biz Ops • The Chemical Threat • Vesicants • Chem Special Instructions • Continuing Challenges • Interagency Partnering • BARDA funding 11 Rad Nuc Background •The detonation of an Improvised Nuclear Device (IND) has the potential to produce a large number of victims with multiple and mixed injuries •Exposure to radiation induces dose-dependent injury to cells and tissue through a cascade of molecular and biochemical changes that lead to cell death or disruption 98-- 7- 6 5- 4- Dangerous Fallout 3- ground-zero 2- --1- 0- Light Damage Miles from 1 kT Moderate Damage 0.1 kT 10 kT MdiMedium Severe Damage Small Large •Acute Radiation Syndrome (ARS) is the medical consequence of approximately 2 Gy exposure •The symptoms and progressionprogression of radiation injuryinjury occur even after the radiation exposure has ceased and there is a continuity of medical consequences from the ARS to the Delayed Effects of the Acute Exposure (DEARE) to chronic radiation damage 2 IND Scenarios and Requirements Development • Hundreds of IND scenarios ─ Developed with modeling and working groups with subject matter experts ─ Several cities modeled ─ Several radiation yields ─ 12 months (Jan - Dec): (e.g. Monthly winds and weather affect the fallout pattern)pattern) • Requirements established from modeling scenarios • Fulfillment of requirements ─ Acquisition of products via Project BioShield contracts ─ Development of products via Advanced Research and Development contracts ─ Review portfolio as requirements change • Requirements are reviewed on a regular basis and do change over time. -
WO 2016/147132 Al 22 September 2016 (22.09.2016) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/147132 Al 22 September 2016 (22.09.2016) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07C 227/32 (2006.01) C07D 405/04 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/IB20 16/05 14 1 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 17 March 2016 (17.03.2016) KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (25) Filing Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (26) Publication Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 895/MUM/2015 18 March 2015 (18.03.2015) (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: PIRAMAL ENTERPRISES LIMITED GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [IN/IN]; Piramal Tower, Ganpatrao Kadam Marg, Lower TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Parel, Mumbai 400 013 (IN). -
The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
University of Montana ScholarWorks at University of Montana Graduate Student Theses, Dissertations, & Graduate School Professional Papers 2010 The seU of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities Joshua Bryant Phillips The University of Montana Let us know how access to this document benefits ouy . Follow this and additional works at: https://scholarworks.umt.edu/etd Recommended Citation Phillips, Joshua Bryant, "The sU e of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities" (2010). Graduate Student Theses, Dissertations, & Professional Papers. 1100. https://scholarworks.umt.edu/etd/1100 This Dissertation is brought to you for free and open access by the Graduate School at ScholarWorks at University of Montana. It has been accepted for inclusion in Graduate Student Theses, Dissertations, & Professional Papers by an authorized administrator of ScholarWorks at University of Montana. For more information, please contact [email protected]. THE USE OF NATURAL PRODUCT SUBSTRATES FOR THE SYNTHESIS OF LIBRARIES OF BIOLOGICALLY ACTIVE, NEW CHEMICAL ENTITIES by Joshua Bryant Phillips B.S. Chemistry, Northern Arizona University, 2002 B.S. Microbiology (health pre-professional), Northern Arizona University, 2002 Presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy Chemistry The University of Montana June 2010 Phillips, Joshua Bryant Ph.D., June 2010 Chemistry THE USE OF NATURAL PRODUCT SUBSTRATES FOR THE SYNTHESIS OF LIBRARIES OF BIOLOGICALLY ACTIVE, NEW CHEMICAL ENTITIES Advisor: Dr. Nigel D. Priestley Chairperson: Dr. Bruce Bowler ABSTRACT Since Alexander Fleming first noted the killing of a bacterial culture by a mold, antibiotics have revolutionized medicine, being able to treat, and often cure life-threatening illnesses and making surgical procedures possible by eliminating the possibility of opportunistic infection. -
ITAR Category
Category XIV—Toxicological Agents, Including Chemical Agents, Biological Agents, and Associated Equipment *(a) Chemical agents, to include: (1) Nerve agents: (i) O-Alkyl (equal to or less than C10, including cycloalkyl) alkyl (Methyl, Ethyl, n-Propyl or Isopropyl)phosphonofluoridates, such as: Sarin (GB): O-Isopropyl methylphosphonofluoridate (CAS 107–44–8) (CWC Schedule 1A); and Soman (GD): O-Pinacolyl methylphosphonofluoridate (CAS 96–64–0) (CWC Schedule 1A); (ii) O-Alkyl (equal to or less than C10, including cycloalkyl) N,N-dialkyl (Methyl, Ethyl, n- Propyl or Isopropyl)phosphoramidocyanidates, such as: Tabun (GA): O-Ethyl N, N- dimethylphosphoramidocyanidate (CAS 77–81–6) (CWC Schedule 1A); (iii) O-Alkyl (H or equal to or less than C10, including cycloalkyl) S–2-dialkyl (Methyl, Ethyl, n- Propyl or Isopropyl)aminoethyl alkyl (Methyl, Ethyl, n-Propyl or Isopropyl)phosphonothiolates and corresponding alkylated and protonated salts, such as: VX: O-Ethyl S-2- diisopropylaminoethyl methyl phosphonothiolate (CAS 50782–69–9) (CWC Schedule 1A); (2) Amiton: O,O-Diethyl S-[2(diethylamino)ethyl] phosphorothiolate and corresponding alkylated or protonated salts (CAS 78–53–5) (CWC Schedule 2A); (3) Vesicant agents: (i) Sulfur mustards, such as: 2-Chloroethylchloromethylsulfide (CAS 2625–76–5) (CWC Schedule 1A); Bis(2-chloroethyl)sulfide (CAS 505–60–2) (CWC Schedule 1A); Bis(2- chloroethylthio)methane (CAS 63839–13–6) (CWC Schedule 1A); 1,2-bis (2- chloroethylthio)ethane (CAS 3563–36–8) (CWC Schedule 1A); 1,3-bis (2-chloroethylthio)-n- propane (CAS -
Assessment of the Behavior of Chemical Warfare Agents in Landfills
Assessment of the Behavior of Chemical Warfare Agents in Landfills S.L. Bartelt-Hunt, M.A. Barlaz D.R.U. Knappe, P. Kjeldsen Dept. of Civil, Construction, & Environmental Engineering North Carolina State University Project Motivation z A chemical and/or biological attack on a building in the U.S. may result in a large amount of contaminated debris that would require disposal z There is little information on the behavior of chemical and biological agents in a landfill Objectives z Model the distribution and behavior of chemical agents in a landfill z Determine which fate routes are most important z Determine sensitivity of results to model input parameters z Bounding calculations to guide experimental work MOCLA Model for Organic Chemicals in Landfills solid (fs) Kd KH Fa FD Soil Cover gas (fa) Waste water (fw) Transformation (Fλ) Fw LCS Fdiff Modified from Kjeldsen and Christensen (2001) MOCLA: Input Parameters Chemical Parameters •Henry’s law constant (dimensionless) •Log Kow •Dair •Dwater • Abiotic half-life • Biotic half-life (λbiotic = ∞) Evaluation of Chemical Fate Prior to Disposal Toxic Industrial Chemicals • Carbon disulfide, furan will be included in bounding calculations • others judged to volatilize prior to landfilling (e.g. ethylene oxide, phosgene) Evaluation of Chemical Fate Prior to Disposal Blister Agents Distilled Mustard (HD) Lewisite (L) All blister agents will be Nitrogen Mustard (HN-2) included in bounding Phosgene Oxime (CX) calculations Ethyldichloroarsine (ED) Evaluation of Chemical Fate Prior to Disposal Nerve -
Chemical Resistance of Plastics
(c) Bürkle GmbH 2010 Important Important information The tables “Chemical resistance of plastics”, “Plastics and their properties” and “Viscosity of liquids" as well as the information about chemical resistance given in the particular product descriptions have been drawn up based on information provided by various raw material manufacturers. These values are based solely on laboratory tests with raw materials. Plastic components produced from these raw materials are frequently subject to influences that cannot be recognized in laboratory tests (temperature, pressure, material stress, effects of chemicals, construction features, etc.). For this reason the values given are only to be regarded as being guidelines. In critical cases it is essential that a test is carried out first. No legal claims can be derived from this information; nor do we accept any liability for it. A knowledge of the chemical and mechanical Copyright This table has been published and updated by Bürkle GmbH, D-79415 Bad Bellingen as a work of reference. This Copyright clause must not be removed. The table may be freely passed on and copied, provided that Extensions, additions and translations If your own experiences with materials and media could be used to extend this table then we would be pleased to receive any additional information. Please send an E-Mail to [email protected]. We would also like to receive translations into other languages. Please visit our website at http://www.buerkle.de from time to Thanks Our special thanks to Franz Kass ([email protected]), who has completed and extended these lists with great enthusiasm and his excellent specialist knowledge.