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This Diagram Was Automatically Generated by SRI International Pathway Tools Version 19.0, Authors S. Paley and P.D. Karp Srs056259Cyc: SRS056259 Cellular Overview COFACTORS, PROSTHETIC GROUPS, ELECTRON CARRIERS BIOSYNTHESIS PENTOSE PHOSPHATE PATHWAYS FATTY ACIDS AND LIPIDS BIOSYNTHESIS 5,6- a β-D-glucan AMINO ACIDS DEGRADATION (S)-1- cytidine S-(2- a dextran dihydrothymine with a C3- dTTP trans- RESPIRATION tryptophan pyrroline-5- (S)-malate an oleoyl- a chlorophyll pheophytin b hydroxyacyl) adenosylcobalamin biosynthesis valine phenylalanine substituted dienelactone methanofuran biosynthesis respiration (anaerobic) degradation IX leucine proline isoleucine 4-hydroxyproline tyrosine carboxylate [acp] glucose glutathione I (early cobalt insertion) adenosylcobalamin biosynthesis biotin methylerythritol pantothenate and adenosylcobalamin pyridine nucleotide cycling (plants) superpathway of mycolate biosynthesis pentose phosphate glutamate degradation II degradation III uridine kinase: putative Nucleoside triphosphate ubiquinol-9 phosphate pathway superpathway chlorophyllide a ubiquinol-8 ubiquinol-7 ubiquinol-10 4-amino-2-methyl-5- 1,4-dihydroxy- thiamin coenzyme B/ pathway (partial) degradation I degradation degradation I degradation I degradation III dextranase O_49561_0 dihydropyrimidine pyrophosphohydrolase II (late cobalt incorporation) biosynthesis I superpathway coenzyme A biosynthesis I ubiquinol-6 salvage from cobinamide II superpathway of fatty degradation V (via STEROIDS DEGRADATION malate/L-lactate laminarinase: Chlorophyllase: Chlorophyllase: hydroxyacylglutathione carboxymethylenebutenolidase- biosynthesis of menaquinol- biosynthesis I biosynthesis biosynthesis biosynthesis phosphomethylpyrimidine 2-naphthoate diphosphate coenzyme M acyl-CoA precursor: carB protein: [+ 84 isozymes] dehydrogenase MazG: O_84600_1 8 biosynthesis I of ubiquinol-8 biosynthesis from regeneration acids biosynthesis (E. coli) 2-phospho- hydroxyglutarate) arginine O_55678_0 dehydrogenase: O_41258_0 O_71214_0 O_71214_0 hydrolase: O_14552_9 related protein: O_59031_0 (eukaryotic) (aerobic, light- dihydroxyacetone biosynthesis (eukaryotic) 4-hydroxybenzoate (eukaryotic) (eukaryotic) biosynthesis (yeast) biosynthesis I biosynthesis hydrolysis sitosterol O_65020_0 precursor: [+ 8 isozymes] uroporphyrinogen-III D-glyceraldehyde phosphoenol β-D-ribosylnicotinate acetyl-CoA D-glycerate D-ribulose trp trans-4- degradation O_19805_0 [+ 32 isozymes] pyruvate dependent) pyruvate phosphate (prokaryotic) 3-methyl-2- (eukaryotic) 5-phospho- II (Bacillus) a 2,3,4- leu ile IV (arginine val phe tyr degradation to CMP O_39892_0 a holo- uroporphyrinogen-III all-trans- 3-phosphate all-trans- all-trans- cobinamide 5-phosphate pro hydroxy- Biosynthetic (2S,5S)-5- a malonyl-[acp] chorismate oxobutanoate dihydromethanophenazine saturated androstenedione cholesterol a dextran [acyl-carrier oleate a β-D glucan a β-D glucan dTMP nonaprenyl (2E,6E)- chorismate all-trans- 4-hydroxybenzoate α-D-ribose 1- chorismate 4-amino-2-methyl-5- acetyl-CoA glt L-proline decarboxylase/ carboxymethyl a chlorophyllide phytol pheophorbide b phytol 2-maleylacetate 4-hydroxybenzoate uroporphyrinogen-III heptaprenyl 4-hydroxybenzoate decaprenyl Enolase (EC Aromatic amino acid degradation to fragment thymine a 2-hydroxy uroporphyrinogen-III diphosphate farnesyl 4-hydroxybenzoate hexaprenyl diphosphate diphosphate diphosphate diphosphomethylpyrimidine Biotin fatty agmatine aminotransferase proline oxaloacetate protein] glutathione 1-deoxy-D- 3-methyl-2-oxobutanoate acyl CoA 4.2.1.11): ribulose- deiminase androstenedione carboxylate C-methyltransferase: uroporphyrinogen-III C- diphosphate diphosphate Cob(I)alamin carboxyl branched-chain amino branched-chain branched-chain alpha (EC sitosterol O_63780_0 methyltransferase: O_63780_0 xylulose 5- isochorismate hydroxymethyltransferase chorismate- putative isochorismate synthase O_37300_0 phosphate Proline pathway) II (cholesterol chorismate adenosyltransferase carrier protein Biotin Palmitoyl- acid aminotransferase/ amino acid amino acid Aspartate/ 2.6.1.57) @ [+ 28 isozymes] 4-hydroxybenzoate phosphate synthase entC: Uroporphyrinogen superpathway of (EC 2.1.2.11): O_16569_4 -pyruvate 4-hydroxybenzoate 4-hydroxybenzoate amidophosphoribosyltransferase: entC: O_30595_9 Thiamin-phosphate carboxyl [+ 47 isozymes] 3-epimerase: NAD-specific dehydrogenase arg dehydrogenase) [+ 28 isozymes] polyprenyltransferase methanofuran octaprenyl- 4-hydroxybenzoate polyprenyltransferase polyprenyltransferase PduO (EC 2.5.1.17) F420H2- acetyl-CoA CoA lysine 4-amino-4- lysine aminotransferase/ aminotransferase/ tyrosine/aromatic Aspartate 2.6.1.1) synthase O_30595_9 decarboxylase (URO- demethylmenaquinol- [+ 23 isozymes] lyase: O_14552_20 [+ 12 isozymes] : O_17433_2 Nicotinate pyrophosphorylase heterodisulfide carboxylase: carrier protein O_30079_5 fermentation glutamate degradation II (EC 1.5.99.8) 3-beta a 6-(N-acetyl-D- superpathay (EC 2.5.1.39) biosynththesis diphosphate polyprenyltransferase (EC 2.5.1.39) (EC 2.5.1.39) dehydrogenase, docosahexanoate hydrolase N-formylkynurenine arginine, ornithine and proline interconversion deoxychorismate 4-amino-4- pyrroline- 4-amino-4- aminotransferase: : O_78604_0 cholesterol 5,6- [chondroitin]- cytidine (EC 2.2.1.7) [+ 12 isozymes] D): O_25697_1 8 biosynthesis O_8460_1 [+ 94 isozymes] [+ 45 isozymes] phosphoribosyltransferase (EC 2.5.1.3): O_793_4 reductase, iron- O_26835_3 acetyl-CoA [+ 44 isozymes] to acetate dehydrogenase (Proline deoxychorismate α-L- uridine an oxidized UTP a long- glucosaminyl)- of heme : O_45860_0 intermediate MF1 synthase: chorismate- asp (EC 2.5.1.39) : O_45860_0 : O_45860_0 beta subunit: biosynthesis II precursor phosphoenol (EC 1.4.1.2) lyase: O_26741_2 oxidase) / Delta- deoxychorismate hydroxy- O_79796_0 4-hydroxyphenylpyruvate[+ 65 isozymes] hydroxysteroid a ribonucleotide (S)-malate dihydrouracil a DsrEFH 4-O-sulfo-N- electron- propanoyl- 2’,3’-cyclic α-D-glucose precorrin-1 precorrin-1 a malonyl-[acp] : O_74958_0 [+ 9 isozymes] (EC 2.4.2.11): O_22672_0 [+ 51 isozymes] sulfur binding carboxylase: and butyrate lyase: O_26741_2 rhamnose linear glucan biosynthesis 4-hydroxybenzoate O_636_1 -pyruvate all-trans- : O_45860_0 4-hydroxybenzoate 4-hydroxybenzoate O_36272_0 [+ 97 isozymes] (EC 3.1.2.2) pyruvate [+ 53 isozymes] lyase: O_26741_2 carboxylate Biosynthetic arginine [+ 65 isozymes] dehydrogenase/ a perthiol acetylgalactosamine monophosphate 1-phosphatidyl- methyl ester [+ 88 isozymes] 2-dehydropantoate [+ 55 isozymes] O_26835_3 D-erythrose NADP-specific 1-pyrroline-5- complex transfer CoA from glutamate chorismate [+ 39 isozymes] lyase: octaprenyl 4-hydroxybenzoate isochorismate subunit, putative: : O_81723_0 D-xylulose [+ 53 isozymes] [+ 53 isozymes] isomerase: 3-beta uridine kinase: putative Nucleoside triphosphate 1D-myo-inositol polyprenyltransferase isochorismate 4-hydroxybenzoate polyprenyltransferase polyprenyltransferase 5-phospho-β- nicotinate β-nicotinate D-ribonucleotide putative F420H2- O_70597_0 [+ 97 isozymes] 5-phosphate 4-phosphate Kynurenine 1.4.1.4): lys carboxylate decarboxylase (EC 2-oxo-3- flavoprotein 2’,3’-cyclic nucleotide O_8460_1 diphosphate polyprenyltransferase adenosylcobinamide [+ 6 isozymes] 4.1.1.19): O_71470_0 O_20538_0 hydroxysteroid L-rhamnose O_49561_0 dihydropyrimidine Chondroitinase pyrophosphohydrolase 4-alpha- uroporphyrinogen-III (EC 2.5.1.39) 1-deoxy-D- coproporphyrinogen III Aspartate 1- (EC 2.5.1.39) (EC 2.5.1.39) D-ribosylamine dehydrogenase: [+ 37 isozymes] α-linolenate Transketolase, C- Transketolase, C- formamidase, lys O_73598_0 arg 4-methyl-2- 1.5.1.12): phenylpropanoate rNA ligase: malate/L-lactate 3’-phosphodiesterase n-acetylglucosaminylphosphatidylinositol uroporphyrinogen-III C- : O_30957_1 (EC 2.5.1.39) : O_30957_1 : O_30957_1 thiamin phosphate O_47857_0 malonyl-CoA pyruvate 3-methyl-2- 3-oxo- dehydrogenase/ mutarotase: [+ 84 isozymes] dehydrogenase (chondroitin lyase) MazG: O_84600_1 glucanotransferase [ C-methyltransferase: 3-oxoacyl- synthase, glt xylulose 5- all-trans- ketopantoate decarboxylase terminal section terminal section bacterial [+ 5 isozymes] oxopentanoate O_31386_0 (S)-3-methyl-2- [+ 52 isozymes] O_4902_3 O_30596_72 dehydrogenase: precursor: : O_12202_0 (EC 3.1.4.37) deacetylase: O_72858_1 methyltransferase: O_63780_0 methanofuran isochorismate : O_30957_1 2-succinyl-6-hydroxy- a 2,3,4- kinase: oxobutanoate 24-ethyl- isomerase: [+ 8 isozymes] (CBM20): O_8649_1 O_63780_0 KASIII (EC 2.3.1.180) phosphate 2-succinyl-6- octaprenyl reductase (EC 4.1.1.11) malonyl-CoA O_37925_0 (EC 2.2.1.1) (EC 2.2.1.1) (EC 3.5.1.9) [+ 5 isozymes] oxopentanoate O_19805_0 a reduced : O_40350_0 [+ 26 isozymes] synthase entC: 4-hydroxybenzoate UbiA 2,4-cyclohexadiene- adenosylcobinamide long-chain saturated Lysine cholest- O_20538_0 UMP O_39892_0 [DsrEFH [+ 63 isozymes] 6-(α-D- [+ 26 isozymes] : O_80260_0 hydroxy-2,4- Radical SAM family biosynththesis diphosphate PanE/ApbA: : O_5915_1 probable nicotinate- coenzyme A [+ 68 isozymes] : O_26568_0 : O_26568_0 : O_77701_1 [chondroitin]- electron- nonaprenyl-4- intermediate MF2 O_30595_9 prenyltransferase 3-heptaprenyl-4- 3-decaprenyl-4- 1-carboxylate amidohydrolase: Thiamine- Malonyl CoA- fatty acid-- fatty acid Lysine 2,3- Arginine ketoglutarate L-4- (4-hydroxyphenyl) 5-ene β-L- a thiol complex] acryloyl-CoA UMP glucosaminyl)- [+ 60 isozymes] cyclohexadiene- protein HutW, similar to O_26461_0 3-hexaprenyl-4- hydroxybenzoate hydroxybenzoate synthase: O_87900_4 nucleotide adenylyltransferase: [+ 106 isozymes] [+ 106 isozymes] 2-oxoglutarate (S)-1- agmatine a ribonucleotide N-acetyl- transfer cytidine 2’- acetate
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