Psychotropic Medications Judicial Reference Guide
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HIGHLIGHTS of PRESCRIBING INFORMATION These Highlights Do
HIGHLIGHTS OF PRESCRIBING INFORMATION • Metabolic Changes: Atypical antipsychotic drugs have been associated with These highlights do not include all the information needed to use metabolic changes that may increase cardiovascular/cerebrovascular risk. CLOZARIL safely and effectively. See full prescribing information for These metabolic changes include: CLOZARIL. o Hyperglycemia and Diabetes Mellitus: Monitor for symptoms of CLOZARIL® (clozapine) tablets, for oral use hyperglycemia including polydipsia, polyuria, polyphagia, and Initial U.S. Approval: 1989 weakness. Monitor glucose regularly in patients with diabetes or at risk for diabetes. (5.9) WARNING: SEVERE NEUTROPENIA; ORTHOSTATIC o Dyslipidemia: Undesirable alterations in lipids have occurred in HYPOTENSION, BRADYCARDIA, AND SYNCOPE; SEIZURE; patients treated with atypical antipsychotics. (5.9) MYOCARDITIS AND CARDIOMYOPATHY; INCREASED o Weight Gain: Significant weight gain has occurred. Monitor weight MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA- gain. (5.9) RELATED PSYCHOSIS • Neuroleptic Malignant Syndrome (NMS): Immediately discontinue and See full prescribing information for complete boxed warning. monitor closely. Assess for co-morbid conditions. (5.10) • Fever: Evaluate for infection and for neutropenia, NMS. (5.11) • Pulmonary Embolism (PE): Consider PE if respiratory distress, chest pain, • Severe Neutropenia: CLOZARIL can cause severe neutropenia, which or deep-vein thrombosis occur. (5.12) can lead to serious and fatal infections. Patients initiating and • Anticholinergic Toxicity: Use cautiously in presence of specific conditions continuing treatment with CLOZARIL must have a baseline blood (e.g., narrow angle glaucoma, use of anticholinergic drugs). (5.13) absolute neutrophil count (ANC) measured before treatment initiation • Interference with Cognitive and Motor Performance: Advise caution when and regular ANC monitoring during treatment (2.1, 5.1). -
Cambridgeshire and Peterborough Joint Prescribing Group MEDICINE REVIEW
Cambridgeshire and Peterborough Joint Prescribing Group MEDICINE REVIEW Name of Medicine / Trimipramine (Surmontil®) Class (generic and brand) Licensed indication(s) Treatment of depressive illness, especially where sleep disturbance, anxiety or agitation are presenting symptoms. Sleep disturbance is controlled within 24 hours and true antidepressant action follows within 7 to 10 days. Licensed dose(s) Adults: For depression 50-75 mg/day initially increasing to 150-300 mg/day in divided doses or one dose at night. The maintenance dose is 75-150 mg/day. Elderly: 10-25 mg three times a day initially. The initial dose should be increased with caution under close supervision. Half the normal maintenance dose may be sufficient to produce a satisfactory clinical response. Children: Not recommended. Purpose of Document To review information currently available on this class of medicines, give guidance on potential use and assign a prescribing classification http://www.cambsphn.nhs.uk/CJPG/CurrentDrugClassificationTable.aspx Annual cost (FP10) 10mg three times daily: £6,991 25mg three times daily: £7,819 150mg daily: £7,410 300mg daily: £14,820 Alternative Treatment Options within Class Tricyclic Annual Cost CPCCG Formulary Classification Antidepressant (FP10) Amitriptyline (75mg) Formulary £36 Lofepramine (140mg) Formulary £146 Imipramine (75mg) Non-formulary £37 Clomipramine (75mg) Non-formulary £63 Trimipramine (75mg). TBC £7,819 Nortriptyline (75mg) Not Recommended (pain) £276 Doxepin (150mg) TBC £6,006 Dosulepin (75mg) Not Recommended (NICE DO NOT DO) £19 Dosages are based on possible maintenance dose and are not equivalent between medications Recommendation It is recommended to Cambridgeshire and Peterborough CCG JPG members and through them to local NHS organisations that the arrangements for use of trimipramine are in line with restrictions agreed locally for drugs designated as NOT RECOMMENDED:. -
The Effects of Antipsychotic Treatment on Metabolic Function: a Systematic Review and Network Meta-Analysis
The effects of antipsychotic treatment on metabolic function: a systematic review and network meta-analysis Toby Pillinger, Robert McCutcheon, Luke Vano, Katherine Beck, Guy Hindley, Atheeshaan Arumuham, Yuya Mizuno, Sridhar Natesan, Orestis Efthimiou, Andrea Cipriani, Oliver Howes ****PROTOCOL**** Review questions 1. What is the magnitude of metabolic dysregulation (defined as alterations in fasting glucose, total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglyceride levels) and alterations in body weight and body mass index associated with short-term (‘acute’) antipsychotic treatment in individuals with schizophrenia? 2. Does baseline physiology (e.g. body weight) and demographics (e.g. age) of patients predict magnitude of antipsychotic-associated metabolic dysregulation? 3. Are alterations in metabolic parameters over time associated with alterations in degree of psychopathology? 1 Searches We plan to search EMBASE, PsycINFO, and MEDLINE from inception using the following terms: 1 (Acepromazine or Acetophenazine or Amisulpride or Aripiprazole or Asenapine or Benperidol or Blonanserin or Bromperidol or Butaperazine or Carpipramine or Chlorproethazine or Chlorpromazine or Chlorprothixene or Clocapramine or Clopenthixol or Clopentixol or Clothiapine or Clotiapine or Clozapine or Cyamemazine or Cyamepromazine or Dixyrazine or Droperidol or Fluanisone or Flupehenazine or Flupenthixol or Flupentixol or Fluphenazine or Fluspirilen or Fluspirilene or Haloperidol or Iloperidone -
Drug Repurposing for the Management of Depression: Where Do We Stand Currently?
life Review Drug Repurposing for the Management of Depression: Where Do We Stand Currently? Hosna Mohammad Sadeghi 1,†, Ida Adeli 1,† , Taraneh Mousavi 1,2, Marzieh Daniali 1,2, Shekoufeh Nikfar 3,4,5 and Mohammad Abdollahi 1,2,* 1 Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran 1417614411, Iran; [email protected] (H.M.S.); [email protected] (I.A.); [email protected] (T.M.); [email protected] (M.D.) 2 Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran 3 Personalized Medicine Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran 1417614411, Iran; [email protected] 4 Pharmaceutical Sciences Research Center (PSRC) and the Pharmaceutical Management and Economics Research Center (PMERC), Evidence-Based Evaluation of Cost-Effectiveness and Clinical Outcomes Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran 1417614411, Iran 5 Department of Pharmacoeconomics and Pharmaceutical Administration, School of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran * Correspondence: [email protected] † Equally contributed as first authors. Citation: Mohammad Sadeghi, H.; Abstract: A slow rate of new drug discovery and higher costs of new drug development attracted Adeli, I.; Mousavi, T.; Daniali, M.; the attention of scientists and physicians for the repurposing and repositioning of old medications. Nikfar, S.; Abdollahi, M. Drug Experimental studies and off-label use of drugs have helped drive data for further studies of ap- Repurposing for the Management of proving these medications. -
Heat Related Illness in Psychotropic Medication Users
Common psychotropic medications which Prevention of Heat can impair your response to heat Related Illness Trade Name Generic Name Abilify aripiprazole During periods of high temperature (85º Asendin amoxapine and above) and humidity, there are things Artane trihexyphenidyl everyone, particularly people at high risk, Aventil, Pamelor nortriptyline should do to lessen the chances of heat Clozaril clozapine illness. Cogentin benztropine Compazine prochlorperazine ¾ Try to stay cool. Desyrel trazodone • Stay in air conditioned areas if Elavil, Limbitrol, possible. If you do not have air Triavil amitriptyline conditioning at home, go to a Eskalith, Lithobid, shopping mall or public library. Lithonate lithium • Keep windows shut and draperies, Geodon ziprasidone shades, or blinds drawn during the Haldol haloperidol heat of the day. Loxitane loxapine • Open windows in the evening or Ludiomil maprotiline night hours when the air outside is Mellaril thioridazine Heat Related Illness cooler. Moban molindone • Move to cooler rooms during the Navane thiothixene in heat of the day. Norpramin desipramine Psychotropic ¾ Avoid overexertion and outdoor Phenergan promethazine activity, particularly during warmer Prolixin fluphenazine Medication Users periods of the day. Risperdal risperidone ¾ Apply sunscreen and lotion as needed. Serentil mesoridazine Seroquel quetiapine ¾ Drink plenty of fluids (avoid coffee, tea, and alcohol). Sinequan doxepin ¾ Dress in loose fitting, light colored Stelazine trifluoperazine clothing. Wear a hat, sunglasses, and Thorazine chlorpromazine other protective clothing. Tofranil imipramine ¾ Take a cool shower or bath. Trilafon perphenazine ¾ Lose weight if you are overweight. Wellbutrin buproprion ¾ Eat regular meals to ensure that you Zyprexa olanzapine Ohio Department of Mental Health have adequate salt and fluids. *Note: This is not an all inclusive list. -
Decomposition Profile Data Analysis of Multiple Drug Effects Identifies
www.nature.com/scientificreports OPEN Decomposition profle data analysis of multiple drug efects identifes endoplasmic reticulum stress‑inducing ability as an unrecognized factor Katsuhisa Morita1,2, Tadahaya Mizuno1,2* & Hiroyuki Kusuhara1* Chemicals have multiple efects in biological systems. Because their on‑target efects dominate the output, their of‑target efects are often overlooked and can sometimes cause dangerous adverse events. Recently, we developed a novel decomposition profle data analysis method, orthogonal linear separation analysis (OLSA), to analyse multiple efects. In this study, we tested whether OLSA identifed the ability of drugs to induce endoplasmic reticulum (ER) stress as a previously unrecognized factor. After analysing the transcriptome profles of MCF7 cells treated with diferent chemicals, we focused on a vector characterized by well‑known ER stress inducers, such as ciclosporin A. We selected fve drugs predicted to be unrecognized ER stress inducers, based on their inducing ability scores derived from OLSA. These drugs actually induced X‑box binding protein 1 splicing, an indicator of ER stress, in MCF7 cells in a concentration‑dependent manner. Two structurally diferent representatives of the fve test compounds exhibited similar results in HepG2 and HuH7 cells, but not in PXB primary hepatocytes derived from human‑liver chimeric mice. These results indicate that our decomposition strategy using OLSA uncovered the ER stress‑inducing ability of drugs as an unrecognized efect, the manifestation of which depended on the background of the cells. Small compounds have the capacity to interact with multiple cellular proteins, thereby mediating multiple efects depending on their exposure to interacting proteins. It is quite difcult to identify the full range of efects of a new chemical, even for its developers, and some factors may be unrecognized. -
A Brief Overview of Psychotropic Medication Use for Persons with Intellectual Disabilities
A BRIEF OVERVIEW OF PSYCHOTROPIC MEDICATION USE FOR PERSONS WITH INTELLECTUAL DISABILITIES INTRODUCTION Individuals with intellectual disabilities are not uncommonly prescribed psychotropic medications. Too often, historically, such agents have been used to try to improve behavioral control without adequate understanding of the antecedents, purpose, and reinforcement of the problematic behavior. While an individual with an intellectual disability may experience a depressive, anxiety, or psychotic disorder in the more typical sense some individuals experience a pattern of anxiety/alarm/arousal leading to affective dysregulation and impulsive behavior. The anxiety can be stimulated by environmental change, physical discomfort, cues related to past trauma, overstimulation, boredom, confusion, or other unpleasant states. Addressing what is causing the distress or reinforcing the behavioral response is the most important thing (though not always easy). Psychotropic medications may be useful for treating more typically presenting psychiatric illnesses as well as being part of more comprehensive plans to attenuate risk behaviors. An individual with intellectual disabilities who seems sad, is withdrawn, shows low energy and lack of interest, is eating or sleeping more or less, or may be more irritable could be suffering from a depression that needs medication treatment. On the other hand an individual with intellectual disabilities who demonstrates aggression, property destruction, self-injury, or other forms of “dyscontrol” may be helped by medication aimed at blunting the anxiety/alarm and/or blocking its escalation into aggression or other dangerous behaviors. In such instances the medications are just part of an overall strategy or plan to help the individual avoid the “need” to engage in such behavior. -
CENTRAL NERVOUS SYSTEM DEPRESSANTS Opioid Pain Relievers Anxiolytics (Also Belong to Psychiatric Medication Category) • Codeine (In 222® Tablets, Tylenol® No
CENTRAL NERVOUS SYSTEM DEPRESSANTS Opioid Pain Relievers Anxiolytics (also belong to psychiatric medication category) • codeine (in 222® Tablets, Tylenol® No. 1/2/3/4, Fiorinal® C, Benzodiazepines Codeine Contin, etc.) • heroin • alprazolam (Xanax®) • hydrocodone (Hycodan®, etc.) • chlordiazepoxide (Librium®) • hydromorphone (Dilaudid®) • clonazepam (Rivotril®) • methadone • diazepam (Valium®) • morphine (MS Contin®, M-Eslon®, Kadian®, Statex®, etc.) • flurazepam (Dalmane®) • oxycodone (in Oxycocet®, Percocet®, Percodan®, OxyContin®, etc.) • lorazepam (Ativan®) • pentazocine (Talwin®) • nitrazepam (Mogadon®) • oxazepam ( Serax®) Alcohol • temazepam (Restoril®) Inhalants Barbiturates • gases (e.g. nitrous oxide, “laughing gas”, chloroform, halothane, • butalbital (in Fiorinal®) ether) • secobarbital (Seconal®) • volatile solvents (benzene, toluene, xylene, acetone, naptha and hexane) Buspirone (Buspar®) • nitrites (amyl nitrite, butyl nitrite and cyclohexyl nitrite – also known as “poppers”) Non-Benzodiazepine Hypnotics (also belong to psychiatric medication category) • chloral hydrate • zopiclone (Imovane®) Other • GHB (gamma-hydroxybutyrate) • Rohypnol (flunitrazepam) CENTRAL NERVOUS SYSTEM STIMULANTS Amphetamines Caffeine • dextroamphetamine (Dexadrine®) Methelynedioxyamphetamine (MDA) • methamphetamine (“Crystal meth”) (also has hallucinogenic actions) • methylphenidate (Biphentin®, Concerta®, Ritalin®) • mixed amphetamine salts (Adderall XR®) 3,4-Methelynedioxymethamphetamine (MDMA, Ecstasy) (also has hallucinogenic actions) Cocaine/Crack -
Medications Approved by the FDA for Bipolar Disorder Medication Brand Name Common Side Effects May Interact With
Medications Approved by the FDA for Bipolar Disorder Medication Brand Name Common side effects May interact with Aripiprazole Abilify® Insomnia Antidepressants such as Prozac or Paxil Nausea Mood stabilizers such as Equetro or Tegretol Restlessness Tiredness Asenapine Saphris® Sleepiness Antihypertensive medications Dizziness Antidepressants Strange sense of taste Anxiety medications Numbing of the mouth Nausea Increased appetite Feeling tired Weight gain Carbamazepine Equetro™ Dizziness Birth control pills (can make them extended release capsules Drowsiness ineffective) Mood stabilizers such as Lithium, Lamictal, Nausea or Depakote Dry mouth Anticonvulsant medications Blurred vision Anxiety medications Decreased white blood cell count Macrolide antibiotics Can rarely cause severe skin Tricyclic antidepressants rashes Cancer medications HIV/AIDS medications Cytotoxic or immunosuppressive Medications Grapefruit juice Cariprazine Vraylar® Muscle stiffness Antidepressants Indigestion Pain medications Vomiting Anxiety medications Sleepiness Mood stabilizers such as Lithium Restlessness Anticonvulsants such as Lamictal Antipsychotics such as Latuda or Seroquel Divalproex Sodium Depakote® Nausea Aspirin or other blood thinning medications Shaking Mood stabilizers such as Equetro,Tegretol, Weight gain or Lamictal Decrease in blood platelets Barbiturates Rash Cyclosporine (Neoral or Sandimmune) Pancreatitis Liver dysfunction (rare) Polycystic Ovary Syndrome (rare) Fluoxetine + Olanzapine Symbyax® Dizziness MAOI antidepressants Drowsiness Antipsychotics -
Trimipramine
PATIENT & CAREGIVER EDUCATION Trimipramine This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Brand Names: US Surmontil [DSC] Brand Names: Canada APO-Trimipramine Warning Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. All people who take this drug need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur. This drug is not approved for use in children. Talk with the doctor. Trimipramine 1/10 What is this drug used for? It is used to treat low mood (depression). What do I need to tell my doctor BEFORE I take this drug? If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have had a recent heart attack. If you have taken certain drugs for depression or Parkinson’s disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen. If you are taking any of these drugs: Linezolid or methylene blue. This is not a list of all drugs or health problems that interact with this drug. -
Prescribing of Trimipramine Is Not Supported (Includes Withdrawal and Cross Tapering Guides)
Prescribing of trimipramine is not supported (includes withdrawal and cross tapering guides) Mid Essex CCG does not support the prescribing of trimipramine as it is not a cost-effective option and lacks evidence of superior efficacy and safety. This position is supported by NHS England as part of the items which should not routinely be prescribed in primary care. Trimipramine is a tricyclic antidepressant (TCA) indicated for the treatment of depressive illness, particularly where sedation is required. However, TCAs are not recommended as a first line treatment option in adults with depression by NICE and they are not recommended at all for children and adolescents (aged under 18 years). Selective Serotonin Reuptake Inhibitors (SSRIs) are preferred as they have less side effects, are safer in overdose, require less dosage titration and only need once daily dosing which may mean better patient adherence. Where a TCA is indicated, as set out by NICE, trimipramine does not represent a cost-effective choice of TCA as it has been subjected to excessive price inflation. More cost effective products are available. Recommendations • TCAs should not be used first line for the treatment of depression. • Patients already being prescribed trimipramine should be reviewed in line with the current NICE clinical guidance. • Ongoing prescribing of antidepressants should be reviewed after six months or two years depending on the person’s risk of relapse. • A trial discontinuation of trimipramine should be considered if long-term maintenance is no longer considered necessary. (See stopping trimipramine or imipramine advice below) • If long-term maintenance is still clinically indicated SSRIs are recommended by NICE as they are equally effective and have a more favourable risk-benefit ratio. -
Currently Prescribed Psychotropic Medications
CURRENTLY PRESCRIBED PSYCHOTROPIC MEDICATIONS Schizophrenia Depression Anxiety Disorders 1st generation antipsychotics: Tricyclics: Atarax (hydroxyzine) Haldol (haloperidol), *Anafranil (clomipramine) Ativan (lorazepam) Haldol Decanoate Asendin (amoxapine) BuSpar (buspirone) Loxitane (loxapine) Elavil (amitriptyline) *Inderal (propranolol) Mellaril (thioridazine) Norpramin (desipramine) Keppra (levetiracetam) Navane (thiothixene) Pamelor (nortriptyline) *Klonopin (clonazepam) Prolixin (fluphenazine), Prolixin Sinequan (doxepin) Librium (chlordiazepoxide) Decanoate Spravato (esketamine) Serax (oxazepam) Stelazine (trifluoperazine) Surmontil (trimipramine) Thorazine (chlorpromazine) *Tenormin (atenolol) Tofranil (imipramine) MEDICATIONS PSYCHOTROPIC PRESCRIBED CURRENTLY Trilafon (perphenazine) Tranxene (clorazepate) Vivactil (protriptyline) Valium (diazepam) 2nd generation antipsychotics: Zulresso (brexanolone) Vistaril (hydroxyzine) Abilify (aripiprazole) Aristada (aripiprazole) SSRIs: Xanax (alprazolam) Caplyta (lumateperone) Celexa (citalopram) *Antidepressants, especially SSRIs, are also used in the treatment of anxiety. Clozaril (clozapine) Lexapro (escitalopram) Fanapt (iloperidone) *Luvox (fluvoxamine) Geodon (ziprasidone) Paxil (paroxetine) Stimulants (used in the treatment of ADD/ADHD) Invega (paliperidone) Prozac (fluoxetine) Invega Sustenna Zoloft (sertraline) Adderall (amphetamine and Perseris (Risperidone injectable) dextroamphetamine) Latuda (lurasidone) MAOIs: Azstarys(dexmethylphenidate Rexulti (brexpiprazole) Emsam (selegiline)