Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Fenchlonine Catalog Number : T1447 CAS Number : 7424-00-2 Molecular Formula : C9H10CINO2 Molecular Weight : 199.63 Apprearence : Solid Melting Point : >240°C

Description: Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

DMSO 2 mg/mL (10 mM) Solubility Water Insoluble ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Receptor (IC50) Hydroxylases

In vivo Activity 4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway[1]. Animal Experiment Animal Model: Sprague-Dawley (SD) rats

Reference 1. Bai Y, et al. Int J Mol Med. 2014, 33(2):373-382.

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