Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT Product Name : Fenchlonine Catalog Number : T1447 CAS Number : 7424-00-2 Molecular Formula : C9H10CINO2 Molecular Weight : 199.63 Apprearence : Solid Melting Point : >240°C Description: Fenclonine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin. Storage: 2 years -80°C in solvent; 3 years -20°C powder; DMSO 2 mg/mL (10 mM) Solubility Water Insoluble ( < 1 mg/ml refers to the product slightly soluble or insoluble ) Receptor (IC50) Hydroxylases In vivo Activity 4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway[1]. Animal Experiment Animal Model: Sprague-Dawley (SD) rats Reference 1. Bai Y, et al. Int J Mol Med. 2014, 33(2):373-382. FOR RESEARCH PURPOSES ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE. Information for product storage and handling is indicated on the product datasheet. Targetmol products are stable for long term under the recommended storage conditions. Our products may be shipped under different conditions as many of them are stable in the short-term at higher or even room temperatures. We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, please follow the storage recommendations on the product data sheet. [email protected] | Tel: +1-781-999-4286 | www.targetmol.com.