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Erzincan, 2015 I ABSTRACTS INVITED LECTURERS IL - 1. GENERATIONS @ WORK __________________________________________________________ 8 IL - 2. NANOMATERIALS IN COSMETICS ____________________________________________________ 9 IL - 3. FEATURE-BASED 3D PHARMACOPHORE MODELS: EFFICIENT MEDICINAL CHEMISTRY DECISION SUPPORT TOOLS ________________________________________________________________ 10 IL - 4. COLLOIDAL CARRIERS AT BIOLOGICAL BARRIERS: CHALLENGES AND NEW CONCEPTS FOR DERMAL AND PULMONARY APPLICATION ___________________________________________________ 11 IL - 5. “HOW A MOLECULE CAN BE CALLED AS A MEDICINAL PRODUCT”: REGISTRATION PROCEDURES IN TURKEY _______________________________________________________________________ 12 IL - 6. RESEARCH AND DEVELOPMENT ACTIVITIES IN PHARMACEUTICAL SECTOR FROM AN ACADEMICIAN POINT OF VIEW ________________________________________________________________ 13 IL - 7. TOXİCİTY OF MYCOTOXİNS _______________________________________________________ 14 IL - 8. NEW HORIZONS IN NANOTHERAPEUTICS: NANOTUBES, QUANTUM DOTS, LIPID BASED CARRIERS, NANOVAULTS, NANOBOATS ______________________________________________________ 15 IL - 9. APPLICATION OF NEW NANO-BASED ELECTROCHEMICAL AND SPECTROSCOPIC SENSORS IN PHARMACEUTICAL ANALYSIS ______________________________________________________ 17 IL - 10. ACTUAL ASPECTS OF THE GLOBAL MARKET OF MEDICAL COSMETICS ______________________ 19 IL - 11. TOXICITY OF DRUG _________________________________ HATA! YER İŞARETİ TANIMLANMAMIŞ. ORAL PRESENTATIONS OP - 1. QUALITY CONTROL OF HERBAL MEDICINES BY CAPILLARY ELECTROPHORESIS COUPLED WITH LASER INDUCED FLUORESCENCE DETECTOR _______________________________________________ 21 OP - 2. TRANSFER OF ADVANCED KNOWLEDGE AND TECHNOLOGIES TO MODERN-DAY EDUCATION ___ 22 OP - 3. CHEMOMETRIC SIGNAL PROCESSING METHODS IN DRUG ANALYSIS _______________________ 23 OP - 4. LIPOSOME FORMULATIONS FOR COSMETIC TEXTILE APPLICATIONS _______________________ 24 OP - 5. PREPARATION AND EVALUATION OF NOVEL MICROEMULSION-BASED HYDROGELS FOR DERMAL DELIVERY OF BENZOCAINE ________________________________________________________ 25 OP - 6. IMPLEMENTATION OF CLINICAL PHARMACY PRACTICES IN HACETTEPE HOSPITALS? __________ 26 OP - 7. HOW MUCH PROGRESS HAS PSYCHIATRY MADE IN THE LAST CENTURY? DO WE KNOW ENOUGH ABOUT THE HUMAN PSYCHE TO PRESCRIBE THE MEDICATION?_____________ 27 OP - 8. HUMAN MEDICINES REGISTRATION PROCESS IN TURKEY ________________________________ 28 OP - 9. THE PHARMACY MANAGEMENT DEPARTMENT’S STUDIES IN TURKEY ______________________ 29 OP - 10. ANTIMUTAGENIC POTENTIALS OF FLAVONOIDS FROM ACHILLEA MILLEFOLIUM L. AND ACHILLEA BIEBERSTEINII AFAN. ____________________________________________________________ 30 OP - 11. STABILITY INDICATING HPLC-PDA ANALYSIS OF FEBUXOSTAT UTILIZING DESIGN OF EXPERIMENTS 31 OP - 12. KOZMETİK SEKTÖRÜNÜN ENDÜSTRİYEL AÇIDAN DEĞERLENDİRİLMESİ _____________________ 32 OP - 13. FORMULATION AND EVALUATIONS OF BETA CYCLODEXTRIN AND POLYETHYLENE GLYCOL MEDIATED BINARY AND TERNARY COMPLEXES OF SYLIMARINE __________________________ 33 OP - 14. FILM COATING OF TABLETS _______________________________________________________ 34 II OP - 15. PROTECTIVE ROLE OF OLEUROPEIN ON ZNOTIO2 NANOCOMPOSITE- INDUCED SOME DEVELOPMENTAL TOXICITY ON DROSOPHILA MELANOGASTER ___________________________ 35 OP - 16. TAURINE IMPROVES CHEMOTHERAPY INDUCED GASTROINTESTINAL TOXICITY IN ACUTE LYMPHOBLASTIC LEUKEMIA. ______________________________________________________ 36 OP - 17. ANTIBREASTCANCER ACTIVITY OF NANOPROPOLIS INDONESIA ON INDUCED MAMMARY TUMOR GLAND BY DMBA IN VIRGIN SPRAGUE-DAWLEY RATS __________________________________ 37 OP - 18. IN VITRO EVALUATION OF THE POTENTIAL OF PREACTIVATED POLY ( ACRYLIC ACID) THIOMERS TO INHIBIT MRP2 EFFLUX TRANSPORTER ______________________________________________ 38 OP - 19. UV-SPECTROPHOTOMETRIC-ASSISTED CHEMOMETRIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF QUINAPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL FORMULATIONS ________________________________________________ 39 OP - 20. SECONDARY METABOLITES OF CULTIVATED ARTEMISIA DRACUNCULUS L. __________________ 40 OP - 21. EFFECT OF AGING, EXERCISE AND CATALASE OVEREXPRESSION ON VARIOUS PROTEIN OXIDATION PRODUCTS IN MICE ____________________________________ 41 OP - 22. DETERMINATION OF IN-VITRO ANTIOXIDANT CAPACITY OF Β - AGONISTS __________________ 42 OP - 23. DEVELOPMENT AND VALIDATION OF LC-MS METHOD FOR DETERMINATION OF HALOPERIDOL IN HUMAN PLASMA _______________________________________________________________ 43 OP - 24. LABEL-FREE SENSING PLATFORM FOR DETECTION OF CHOLESTEROL ______________________ 44 POSTER PRESENTATIONS PP - 1. CYTOTOXIC EFFECT OF HELIX ASPERSA EXTRACT ON HUMAN BREAST CANCER CELL LINE HS578T 46 PP - 2. DETERMINATION OF FRUCTOSE IN SWEETENED FOODS AND BEVERAGES __________________ 47 PP - 3. DEVELOPMENT OF TECHNOLOGY AND DOSAGE FORM DESIGN FOR TARGETED DRUG DELIVERY 48 PP - 4. TAURINE IMPROVES CARBAMAZEPINE INDUCED DROWSINESS. __________________________ 49 PP - 5. "ANTI-ASTHMATIC ACTIVITY OF EUPHORBIA GRANDIALATA R. CULTIVATED IN EGYPT" ________ 50 PP - 6. DETERMINATION OF DABIGATRAN IN PHARMACEUTICAL PREPARATIONS BY DIFFERENTIAL PULSE VOLTAMMETRIC METHOD ________________________________________________________ 51 PP - 7. DETERMINATION OF SOME METAL LEVELS IN MULTIVITAMIN PREPARATIONS WITH ICP-OES AFTER DRY, WET AND MICROWAVE DIGESTION METHODS ____________________________________ 52 PP - 8. LIPOIDAL MATTERS, FLAVONOID CONTENT AND HYPOLIPIDEMIC ACTIVITY OF SPINACH ROOTS AND FLOWERS _____________________________________________________________________ 53 PP - 9. ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF LEPIDIUM SATIVUM EXTRACTS ___________ 54 PP - 10. DESIGN, SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATIONS OF N-HETROARYL DICHLOROACETAMIDE DERIVATIVES AS ANTICANCER AGENTS ___________________________ 55 PP - 11. SAFETY ASSESSMENT OF OSTHOLE ISOLATED FROM PRANGOS FERULACEA: ACUTE AND SUBCHRONIC TOXICITIES AND MODULATION OF CYTOCHROME P450 _____________________ 56 PP - 12. STABILIZATION OF AMORPHOUS CANDESARTAN CILEXETIL AS AN APPROACH TO INCREASE ITS AQUEOUS SOLUBILITY ___________________________________________________________ 57 PP - 13. SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NEW 3-ALKYL(ARYL)-4-(2-PHENYLACETOXY-3- ETHOXYBENZYLIDENAMINO)-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-5-ONES* ____________________ 58 III PP - 14. EFFECT OF OZONE ON REMOTE ORGAN INJURY IN RATS WITH HEPATIC ISCHEMIA-REPERFUSION INJURY _______________________________________________________________________ 59 PP - 15. DEVELOPMENT OF A NANOEMULSION FORMULATION OF WILD OREGANO ESSENTIAL OIL _____ 60 PP - 16. ELECTRO-OXIDATION BEHAVIOR OF DEXAMETHASONE ON THE MODIFIED-MULTI WALLED CARBON NANOTUBE ELECTRODE AND ITS APPLICATION TO BIOLOGICAL SAMPLES __________________ 61 PP - 17. HIGHLY EFFICIENT, ONE POT, SOLVENT FREE ACCESS TO SOME NOVEL QUINAZOLINONE DERIVATIVES USING PTSA (P-TOLUENESULFONIC_ACID) AS CATALYST: SYNTHESIS AND ANTIFUNGAL ACTIVITY EVALUATION ________________________________________________ 62 PP - 18. SIMULTANEOUS DETERMINATION OF CLORSULON AND IVERMECTIN IN VETERINARY INJECTABLE PREPARATION BY A NEW UPLC METHOD ____________________________________________ 63 PP - 19. CHEMICAL COMPOSITION OF LIMONIUM THOUINII (VIV.) KUNTZE (PLUMBAGINACEAE) AND THE DPPH FREE RADICAL SCAVENGING ACTIVITY __________________________________________ 64 PP - 20. FORMULATION AND EVALUATION OF KETOCONAZOLE LIPOSOMES USING INJECTION METHOD _ 65 PP - 21. DEVELOPMENT AND VALIDATION OF AN UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CAPSAICIN IN THE RED HOT CHILLI PEPPER __________________________ 66 PP - 22. DEVELOPMENT AND VALIDATION OF A VIS SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF TOTAL PHENOLIC COMPOUNDS IN THE RED HOT CHILLI PEPPER _________ 67 PP - 23. AN INVESTIGATION ON PROTECTIVE EFFECT OF GILABURU (VIBURNUM OPULUS L.) FRUIT AGAINST ISCHEMIA/REPERFUSION-INDUCED OXIDATIVE STRESS AFTER LUNG TRANSPLANTATION IN RAT 68 PP - 24. APITERAPY ____________________________________________________________________ 69 PP - 25. ENTOMOTHERAPY AND TURKEY ___________________________________________________ 70 PP - 26. THE POTENTIAL OF ARTHROPODS CAUSES VENOM ALLERGY AT TURKEY ___________________ 71 PP - 27. DIABETES MELLITUS AND ASSOCIATED FACTORS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED INDIVIDUALS AT JIMMA UNIVERSITY SPECIALIZED HOSPITAL, SOUTHWEST ETHIOPIA _________ 72 PP - 28. DETERMINATION TOXIC EFFECT OF NEW SYNTHESIZE CHEMICAL COMPOUNDS IN VITRO. _____ 73 PP - 29. GENOTOXIC AND ANTIGENOTOXIC EFFECT OF NEW SYNTHESIZE CHEMICAL COMPOUNDS ON HUMAN LYMPHOCYTE IN VITRO. ___________________________________________________ 74 PP - 30. ACTIVATORS OF CARBONIC ANHYDRASE I AND II: OSAJIN AND POMIFERIN _________________ 75 PP - 31. GENOTOXIC AND ANTIGENOTOXIC EFFECT OF SOME LICHENS____________________________ 76 PP - 32. DETERMINATION OF ANTIOXIDANT CAPACITY OF TWO LICHENS IN VITRO __________________ 77 PP - 33. THE POTENTIAL OF PLANTS ARE IMPORTANT IN TERMS OF IMPLICATION THE HONEY, POLLEN, PROPOLIS USED IN APITHERAPY ___________________________________________________ 78 PP - 34. DETERMINATION OF GENOTOXIC AND ANTIGENOTOXIC EFFECT OF NEW SYNTHESIZE ORGANIC COMPOUNDS __________________________________________________________________ 79 PP - 35. DETERMINATION OF CYTOTOXIC AND ANTICYTOTOXIC EFFECT OF NEW SYNTHESIZE CONPOUNDS _____________________________________________________________________________ 80 PP - 36. GENOTOXIC AND ANTIGENOTOXIC EFFECT OF SOME LICHENS____________________________
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    Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT Product Name : Orobol Catalog Number : TN2019 CAS Number : 480-23-9 Molecular Formula : C15H10O6 Molecular Weight : 286.20 Description: Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover, it has sensitization effect, it can produce produced cisplatin (DDP) sensitivity in human ovarian carcinoma cells by inducing apoptosis through the MT-dependent signaling pathway. Storage: 2 years -80°C in solvent; 3 years -20°C powder; PI3K Receptor (IC50) Caspase Bcl-2 In vitro Activity Isoflavonoid compounds, genistein, psi-tectorigenin and Orobol have been implicated as inhibitors of tyrosine-specific protein kinase and phosphatidylinositol turnover. These compounds have been frequently used as a pharmacological tool to assess signal transduction pathways in various cell systems. In the course of analyzing signaling pathways in rat hepatocytes, we obtained an unexpected finding that these compounds transiently increase cytoplasmic free calcium. Since the Ca2+ mobilizing effect was observed in 1 microM calcium containing buffer, the source of the Ca2+ may be intracellular stores. Reference 1. Isoflavonoids, genistein, psi-tectorigenin, and orobol, increase cytoplasmic free calcium in isolated rat hepatocytes.Biochem Biophys Res Commun. 1992 Jan 31;182(2):894-9. FOR RESEARCH PURPOSES ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE. Information for product storage and handling is indicated on the product datasheet. Targetmol products are stable for long term under the recommended storage conditions. Our products may be shipped under different conditions as many of them are stable in the short-term at higher or even room temperatures. We ensure that the product is shipped under conditions that will maintain the quality of the reagents.
  • ( 12 ) United States Patent

    ( 12 ) United States Patent

    US010722444B2 (12 ) United States Patent ( 10 ) Patent No.: US 10,722,444 B2 Gousse et al. (45 ) Date of Patent : Jul. 28 , 2020 (54 ) STABLE HYDROGEL COMPOSITIONS 4,605,691 A 8/1986 Balazs et al . 4,636,524 A 1/1987 Balazs et al . INCLUDING ADDITIVES 4,642,117 A 2/1987 Nguyen et al. 4,657,553 A 4/1987 Taylor (71 ) Applicant: Allergan Industrie , SAS , Pringy (FR ) 4,713,448 A 12/1987 Balazs et al . 4,716,154 A 12/1987 Malson et al. ( 72 ) 4,772,419 A 9/1988 Malson et al. Inventors: Cécile Gousse , Dingy St. Clair ( FR ) ; 4,803,075 A 2/1989 Wallace et al . Sébastien Pierre, Annecy ( FR ) ; Pierre 4,886,787 A 12/1989 De Belder et al . F. Lebreton , Annecy ( FR ) 4,896,787 A 1/1990 Delamour et al. 5,009,013 A 4/1991 Wiklund ( 73 ) Assignee : Allergan Industrie , SAS , Pringy (FR ) 5,087,446 A 2/1992 Suzuki et al. 5,091,171 A 2/1992 Yu et al. 5,143,724 A 9/1992 Leshchiner ( * ) Notice : Subject to any disclaimer , the term of this 5,246,698 A 9/1993 Leshchiner et al . patent is extended or adjusted under 35 5,314,874 A 5/1994 Miyata et al . U.S.C. 154 (b ) by 0 days. 5,328,955 A 7/1994 Rhee et al . 5,356,883 A 10/1994 Kuo et al . (21 ) Appl . No.: 15 /514,329 5,399,351 A 3/1995 Leshchiner et al . 5,428,024 A 6/1995 Chu et al .
  • Flavonoid Systematics of North American

    Flavonoid Systematics of North American

    FLAVONOID SYSTEMATICS OF NORTH AMERICAN LUPINUS SPECIES (LEGUMINOSAE) by KEVIN WILLIAM NICHOLLS B.Sc.(Hons .), University College of Wales, Aberystwyth, 1972 A THESIS SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY i n THE FACULTY OF GRADUATE STUDIES (Department of Botany) We accept this thesis as conforming to the required standard THE UNIVERSITY OF"BRITISH COLUMBIA August 1981 © Kevin William Nicholls, 1981 In presenting this thesis in partial fulfilment of the requirements for an advanced degree at the University of British Columbia, I agree that the Library shall make it freely available for reference and study. I further agree that permission for extensive copying of this thesis for scholarly purposes may be granted by the head of my department or by his or her representatives. It is understood that copying or publication of this thesis for financial gain shall not be allowed without my written permission. Department The University of British Columbia 2075 Wesbrook Place Vancouver, Canada V6T 1W5 Date I-»TT> c i i / -in \ 11 ABSTRACT This study was an assessment of the usefulness of flav- onoids as taxonomic markers in the genus Lupinus (Leguminosae). The genus itself is readily recognizable, but, in North America, specific boundaries are poorly defined. This is probably the result of a combination of considerable morphological plasticity and hybridization (particularly amongst the outcrossing peren• nial taxa). At the outset, a detailed analysis of L u p i n u s flavonoids was made. Fifty-six compounds were identified, the majority being flavones based on apigenin, luteolin and less commonly acacetin and chrysoeriol.