Underactive Thyroid
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Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells
nutrients Article Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells Perrine Vermonden 1, Matthias Vancoppenolle 1, Emeline Dierge 1,2, Eric Mignolet 1,Géraldine Cuvelier 1, Bernard Knoops 1, Melissa Page 1, Cathy Debier 1, Olivier Feron 2,† and Yvan Larondelle 1,*,† 1 Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Croix du Sud 4-5/L7.07.03, B-1348 Louvain-la-Neuve, Belgium; [email protected] (P.V.); [email protected] (M.V.); [email protected] (E.D.); [email protected] (E.M.); [email protected] (G.C.); [email protected] (B.K.); [email protected] (M.P.); [email protected] (C.D.) 2 Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200 Brussels, Belgium; [email protected] * Correspondence: [email protected]; Tel.: +32-478449925 † These authors contributed equally to this work. Abstract: Plant-derived conjugated linolenic acids (CLnA) have been widely studied for their pre- ventive and therapeutic properties against diverse diseases such as cancer. In particular, punicic acid (PunA), a conjugated linolenic acid isomer (C18:3 c9t11c13) present at up to 83% in pomegranate seed oil, has been shown to exert anti-cancer effects, although the mechanism behind its cytotoxicity remains unclear. Ferroptosis, a cell death triggered by an overwhelming accumulation of lipid perox- ides, has recently arisen as a potential mechanism underlying CLnA cytotoxicity. In the present study, we show that PunA is highly cytotoxic to HCT-116 colorectal and FaDu hypopharyngeal carcinoma cells grown either in monolayers or as three-dimensional spheroids. -
Dietary Pomegranate Pulp to Improve Meat Fatty Acid Composition in Lambs
Dietary pomegranate pulp to improve meat fatty acid composition in lambs Natalello A., Luciano G., Morbidini L., Priolo A., Biondi L., Pauselli M., Lanza M., Valenti B. in Ruiz R. (ed.), López-Francos A. (ed.), López Marco L. (ed.). Innovation for sustainability in sheep and goats Zaragoza : CIHEAM Options Méditerranéennes : Série A. Séminaires Méditerranéens; n. 123 2019 pages 173-176 Article available on line / Article disponible en ligne à l’adresse : -------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------ http://om.ciheam.org/article.php?IDPDF=00007880 -------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------ To cite this article / Pour citer cet article -------------------------------------------------------------------------------------------------------------------------------- ------------------------------------------ Natalello A., Luciano G., Morbidini L., Priolo A., Biondi L., Pauselli M., Lanza M., Valenti B. Dietary pomegranate pulp to improve meat fatty acid composition in lambs. In : Ruiz R. (ed.), López- Francos A. (ed.), López Marco L. (ed.). Innovation for sustainability in sheep and goats. Zaragoza : CIHEAM, 2019. p. 173-176 (Options Méditerranéennes : Série A. Séminaires Méditerranéens; n. 123) -------------------------------------------------------------------------------------------------------------------------------- -
Conjugated Linolenic Fatty Acids Trigger Ferroptosis in Triple-Negative Breast Cancer
bioRxiv preprint doi: https://doi.org/10.1101/556084; this version posted February 20, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Conjugated linolenic fatty acids trigger ferroptosis in triple-negative breast cancer Alexander Beatty1, Tanu Singh1, Yulia Y. Tyurina2,3, Emmanuelle Nicolas1, Kristen Maslar4, Yan Zhou1, Kathy Q. Cai1, Yinfei Tan1, Sebastian Doll5, Marcus Conrad5, Hülya Bayır2,3,6, Valerian E. Kagan2,3,7,8,9,10, Ulrike Rennefahrt11, Jeffrey R. Peterson1* 1 Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA 2 Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 3 Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA, 4 Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA 5 Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany 6 Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 7 Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA, 8 Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA, 9 Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA, 10 Laboratory of Navigational Redox Lipidomics, IM Sechenov Moscow State Medical University, Moscow, Russia 11 Metanomics Health GmbH, Berlin, Germany * corresponding author, e-mail: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/556084; this version posted February 20, 2019. -
Evaluation of Patient with Thyroid Disorders
IJRPC 2013, 3(2) Roshni et al. ISSN: 22312781 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Review Article EVALUATION OF PATIENT WITH THYROID DISORDERS Roshni PR*, Rajan VK, Meenuvijayan and RemyaReghu Department of Pharmacy Practice, Amrita School of Pharmacy, Kochi, Kerala, Thiruvanthapuram, India. The thyroid gland is one of the is difficult to demarcate the gland's upper and largest endocrine glands. The thyroid gland is lower border with vertebral levels because it found in the neck, below the thyroid moves position in relation to these during cartilage (which forms the laryngeal swallowing. prominence, or "Adam's apple"). The isthmus The thyroid gland is covered by a thin fibrous (the bridge between the two lobes of the sheath, the capsulaglandulaethyroidea, thyroid) is located inferior to the cricoid composed of an internal and external layer. cartilage. The external layer is anteriorly continuous with The thyroid gland controls how quickly the the lamina pretrachealis fasciae cervicalis and body uses energy, makes proteins, and posteriorolaterally continuous with the carotid controls how sensitive the body is to sheath. The gland is covered anteriorly other hormones. It participates in these with infrahyoid muscles and laterally with processes by producing thyroid hormones, the the sternocleidomastoid muscle also known as principal ones being tri iodothyronine (T3) and sternomastoid muscle. On the posterior side, a thyroxin which can sometimes be referred to the gland is fixed to the cricoid and tracheal as tetraiodothyronine (T4). These hormones cartilage and cricopharyngeus muscle by a regulate the rate of metabolism and affect the thickening of the fascia to form the posterior growth and rate of function of many other suspensory ligament of Berry1,2. -
Fluorinated Analogues of Glutamic Acid and Glutamine R
γ-Fluorinated analogues of glutamic acid and glutamine R. Dave, B. Badet, Patrick Meffre To cite this version: R. Dave, B. Badet, Patrick Meffre. γ-Fluorinated analogues of glutamic acid and glutamine. Amino Acids, Springer Verlag, 2003, 24 (3), pp.245-261. 10.1007/s00726-002-0410-9. hal-02002676 HAL Id: hal-02002676 https://hal.archives-ouvertes.fr/hal-02002676 Submitted on 11 Feb 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. γ-Fluorinated analogues of glutamic acid and glutamine Review Article 1 2 1 R. Dave , B. Badet , and P. Meffre 1 UMR 7573-C.N.R.S., ENSCP, Paris, France 2 UPR 2301-CNRS, ICSN, Gif-sur-Yvette, France Summary. γ-Fluorinated analogues of glutamic acid and glutamine N-bromosuccinimide; NFSi, N-fluorobenzenesulfonimide; NMR, are compounds of biological interest. Syntheses of such compounds nuclear magnetic resonance; 2-PrOH, isopropanol; PTSA, p- are extensively reviewed in this article. 4-Fluoroglutamic acid toluenesulfonic acid; TCDI, thiocarbonyldiimidazole; TEMPO, was prepared as a mixture of racemic diastereomers by Michael 2,2,6,6-tetramethyl piperidine-1-oxyl; TFA, trifluoroacetic acid. reaction, inverse-Michael reaction or by electrophilic / nucleophilic fluorination. -
Synthetic Turf Scientific Advisory Panel Meeting Materials
California Environmental Protection Agency Office of Environmental Health Hazard Assessment Synthetic Turf Study Synthetic Turf Scientific Advisory Panel Meeting May 31, 2019 MEETING MATERIALS THIS PAGE LEFT BLANK INTENTIONALLY Office of Environmental Health Hazard Assessment California Environmental Protection Agency Agenda Synthetic Turf Scientific Advisory Panel Meeting May 31, 2019, 9:30 a.m. – 4:00 p.m. 1001 I Street, CalEPA Headquarters Building, Sacramento Byron Sher Auditorium The agenda for this meeting is given below. The order of items on the agenda is provided for general reference only. The order in which items are taken up by the Panel is subject to change. 1. Welcome and Opening Remarks 2. Synthetic Turf and Playground Studies Overview 4. Synthetic Turf Field Exposure Model Exposure Equations Exposure Parameters 3. Non-Targeted Chemical Analysis Volatile Organics on Synthetic Turf Fields Non-Polar Organics Constituents in Crumb Rubber Polar Organic Constituents in Crumb Rubber 5. Public Comments: For members of the public attending in-person: Comments will be limited to three minutes per commenter. For members of the public attending via the internet: Comments may be sent via email to [email protected]. Email comments will be read aloud, up to three minutes each, by staff of OEHHA during the public comment period, as time allows. 6. Further Panel Discussion and Closing Remarks 7. Wrap Up and Adjournment Agenda Synthetic Turf Advisory Panel Meeting May 31, 2019 THIS PAGE LEFT BLANK INTENTIONALLY Office of Environmental Health Hazard Assessment California Environmental Protection Agency DRAFT for Discussion at May 2019 SAP Meeting. Table of Contents Synthetic Turf and Playground Studies Overview May 2019 Update ..... -
Redalyc.Chemical and Physiological Aspects of Isomers of Conjugated
Ciência e Tecnologia de Alimentos ISSN: 0101-2061 [email protected] Sociedade Brasileira de Ciência e Tecnologia de Alimentos Brasil Teixeira de CARVALHO, Eliane Bonifácio; Louise Pereira de MELO, Illana; MANCINI- FILHO, Jorge Chemical and physiological aspects of isomers of conjugated fatty acids Ciência e Tecnologia de Alimentos, vol. 30, núm. 2, abril-junio, 2010, pp. 295-307 Sociedade Brasileira de Ciência e Tecnologia de Alimentos Campinas, Brasil Available in: http://www.redalyc.org/articulo.oa?id=395940100002 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative Ciência e Tecnologia de Alimentos ISSN 0101-2061 Chemical and physiological aspects of isomers of conjugated fatty acids Aspectos químicos e fisiológicos de isômeros conjugados de ácidos graxos Revisão Eliane Bonifácio Teixeira de CARVALHO1, Illana Louise Pereira de MELO1, Jorge MANCINI-FILHO1* Abstract Conjugated fatty acid (CFA) is the general term to describe the positional and geometric isomers of polyunsaturated fatty acids with conjugated double bonds. The CFAs of linoleic acid (CLAs) are found naturally in foods derived from ruminant animals, meat, or dairy products. The CFAs of α-linolenic acid (CLNAs) are found exclusively in various types of seed oils of plants. There are many investigations to assess the effects to health from CFAs consumption, which have been associated with physiological processes that are involved with non transmissible chronic diseases such as cancer, atherosclerosis, inflammation, and obesity. Conclusive studies about the CFAs effects in the body are still scarce and further research about their participation in physiological processes are necessary. -
USP Statement on Validation of DNA Test Methods for Regulating the Quality of Herbal Supplements
USP Statement on Validation of DNA Test Methods for Regulating the Quality of Herbal Supplements U.S. PHARMACOPEIAL CONVENTION The United States Pharmacopeial Convention Urges Scientific Validation of DNA Test Methods for Regulating the Quality of Herbal Supplements (Rockville, MD – April 16, 2015) – In response to an agreement announced between the New York State Attorney General (NYAG) and GNC Holdings, Inc. (GNC) the United States Pharmacopeial Convention (USP), an independent, science based, standards setting organization and publishers of the United States Pharmacopeia-National Formulary (USP-NF), an official compendia of quality standards for dietary supplements sold in the U.S., issued the following statement: Statement by Gabriel Giancaspro, PhD – Vice President –Foods, Dietary Supplement and Herbal Medicines United States Pharmacopeial Convention (USP) “As a science-based standards-setting organization, the United States Pharmacopeial Convention (USP) has a keen interest in adopting emerging technologies to ensure the test methods and quality standards included in the United States Pharmacopeia-National Formulary (USP-NF) are current and reflect the state of the industry. DNA testing including DNA Barcoding, is just one example of a technology that has been recently added to the USP-NF. As of December 2014, DNA-based identification methods are included in the official USP chapter <563> Identification of Articles of Botanical Origin. However, this method is not yet referenced in a USP-NF monograph (quality standard) for a specific ingredient or product. That is because USP quality standards are specific for each ingredient, product and dosage form and the standards we develop include only those test methods that have been scientifically validated and shown to be fit for purpose. -
Alphabetical Index of Substances and Articles
ALPHABETICAL INDEX OF SUBSTANCES AND ARTICLES - 355 - NOTES TO THE INDEX 1. This index is an alphabetical list of the substances and articles which are listed in numerical order in the Dangerous Goods List in Chapter 3.2. 2. For the purpose of determining the alphabetical order the following information has been ignored even when it forms part of the proper shipping name: numbers; Greek letters; the abbreviations “sec” and “tert”; and the letters “N” (nitrogen), “n” (normal), “o” (ortho) “m” (meta), “p” (para) and “N.O.S.” (not otherwise specified). 3. The name of a substance or article in block capital letters indicates a proper shipping name. 4. The name of a substance or article in block capital letters followed by the word “see” indicates an alternative proper shipping name or part of a proper shipping name (except for PCBs). 5. An entry in lower case letters followed by the word “see” indicates that the entry is not a proper shipping name; it is a synonym. 6. Where an entry is partly in block capital letters and partly in lower case letters, the latter part is considered not to be part of the proper shipping name. 7. A proper shipping name may be used in the singular or plural, as appropriate, for the purposes of documentation and package marking. - 356 - INDEX Name and description Class UN No. Name and description Class UN No. Accumulators, electric, see 4.3 3292 Acid mixture, nitrating acid, see 8 1796 8 2794 8 2795 Acid mixture, spent, nitrating acid, see 8 1826 8 2800 8 3028 Acraldehyde, inhibited, see 6.1 1092 ACETAL 3 1088 -
Devon Locally Led Inquiry Grasslands and Livestock Production in Devon Contents
Devon Locally Led Inquiry Grasslands and Livestock Production in Devon Contents Preface 3 Key messages 4 Introduction 5 Flying the flag for grass 6 Grasslands’ contribution to agriculture 8 Agriculture in the regional economy 10 Nutrition related to grass-based livestock production 12 Climate-related complexities 14 Recommendations 17 References 18 Thanks The RSA Food, Farming and Countryside Commission would like to thank: Beth Dooley and Matt Lobley for their invaluable work enabling the working groups turn their research ideas into action; David Fursdon for chairing the Devon Committee so ably; Members of the Committee for their generosity in volunteering their time and expertise: Andrew Butler, Elaine Cook, Kevin Cox, Stephen Criddle, Keri Denton, Tim Dudgeon, Henri Greig, Peter Greig, Catherine Mead, Richard Pocock, Mary Quicke, Mel Squires, and the many additional stakeholders who shared their insights and networks. Preface Launched in November 2017, the RSA Food, from Devon and neighbouring Cornwall. This Farming and Countryside Commission is a major, Committee identified four key issues: Health and two-year independent inquiry, funded by Esmée Thriving Communities; New Entrants; Devon’s Fairbairn Foundation. Grasslands, and Environment and Biodiversity. Each of these were explored by their own working Chaired by Sir Ian Cheshire, with fourteen group, chaired by a member of the Committee. Commissioners from across sectors, the Work took place between June 2018 and May Commission is tasked with creating mandate for 2019. change across our food system, farming sector The Devon Committee were ably assisted by and in rural communities; shaping a long term Professor Matt Lobley and Beth Dooley from the vision for the future that’s fairer, stands the test University of Exeter who acted as lead researchers of time and aligns more closely with changing and authors. -
IODINE Its Properties and Technical Applications
IODINE Its Properties and Technical Applications CHILEAN IODINE EDUCATIONAL BUREAU, INC. 120 Broadway, New York 5, New York IODINE Its Properties and Technical Applications ¡¡iiHiüíiüüiütitittüHiiUitítHiiiittiíU CHILEAN IODINE EDUCATIONAL BUREAU, INC. 120 Broadway, New York 5, New York 1951 Copyright, 1951, by Chilean Iodine Educational Bureau, Inc. Printed in U.S.A. Contents Page Foreword v I—Chemistry of Iodine and Its Compounds 1 A Short History of Iodine 1 The Occurrence and Production of Iodine ....... 3 The Properties of Iodine 4 Solid Iodine 4 Liquid Iodine 5 Iodine Vapor and Gas 6 Chemical Properties 6 Inorganic Compounds of Iodine 8 Compounds of Electropositive Iodine 8 Compounds with Other Halogens 8 The Polyhalides 9 Hydrogen Iodide 1,0 Inorganic Iodides 10 Physical Properties 10 Chemical Properties 12 Complex Iodides .13 The Oxides of Iodine . 14 Iodic Acid and the Iodates 15 Periodic Acid and the Periodates 15 Reactions of Iodine and Its Inorganic Compounds With Organic Compounds 17 Iodine . 17 Iodine Halides 18 Hydrogen Iodide 19 Inorganic Iodides 19 Periodic and Iodic Acids 21 The Organic Iodo Compounds 22 Organic Compounds of Polyvalent Iodine 25 The lodoso Compounds 25 The Iodoxy Compounds 26 The Iodyl Compounds 26 The Iodonium Salts 27 Heterocyclic Iodine Compounds 30 Bibliography 31 II—Applications of Iodine and Its Compounds 35 Iodine in Organic Chemistry 35 Iodine and Its Compounds at Catalysts 35 Exchange Catalysis 35 Halogenation 38 Isomerization 38 Dehydration 39 III Page Acylation 41 Carbón Monoxide (and Nitric Oxide) Additions ... 42 Reactions with Oxygen 42 Homogeneous Pyrolysis 43 Iodine as an Inhibitor 44 Other Applications 44 Iodine and Its Compounds as Process Reagents ... -
Used at Rocky Flats
. TASK 1 REPORT (Rl) IDENTIFICATION OF CHEMICALS AND RADIONUCLIDES USED AT ROCKY FLATS I PROJECT BACKGROUND ChemRisk is conducting a Rocky Flats Toxicologic Review and Dose Reconstruction study for The Colorado Department of Health. The two year study will be completed by the fall of 1992. The ChemRisk study is composed of twelve tasks that represent the first phase of an independent investigation of off-site health risks associated with the operation of the Rocky Flats nuclear weapons plant northwest of Denver. The first eight tasks address the collection of historic information on operations and releases and a detailed dose reconstruction analysis. Tasks 9 through 12 address the compilation of information and communication of the results of the study. Task 1 will involve the creation of an inventory of chemicals and radionuclides that have been present at Rocky Flats. Using this inventory, chemicals and radionuclides of concern will be selected under Task 2, based on such factors as the relative toxicity of the materials, quantities used, how the materials might have been released into the environment, and the likelihood for transport of the materials off-site. An historical activities profile of the plant will be constructed under Task 3. Tasks 4, 5, and 6 will address the identification of where in the facility activities took place, how much of the materials of concern were released to the environment, and where these materials went after the releases. Task 7 addresses historic land-use in the vicinity of the plant and the location of off-site populations potentially affected by releases from Rocky Flats.