The Chemistry, Pharmacology and Clinical Properties of Sambucus Ebulus: a Review
Journal of Medicinal Plants Research Vol. 4(2), pp. 095-103, 18 January, 2010 Available online at http://www.academicjournals.org/JMPR DOI: 10.5897/JMPR09.026 ISSN 1996-0875© 2010 Academic Journals Review The chemistry, pharmacology and clinical properties of Sambucus ebulus: A review M. Shokrzadeh1 and S. S. Saeedi Saravi2* 1Department of Toxicology-Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. 2Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Accepted 16 December, 2009 Sambucus ebulus is known as dwarf elder or elderberry. S. ebulus extracts are an important area in drug development with numerous pharmacological functions in the Middle East. However, their pharmacological functions have not been clearly studied. For a long time, S. ebulus has been prescribed in traditional medicines for the treatment of inflammatory reactions, such as hemorrhoid, bites and sore-throat. In addition, S. ebulus has recently been shown to have anti-inflammatory, anti- nociceptive, anti-cancer, anti-angiogenic and anti-oxidative activities. Ebulitin, ebulin 1, flavonoid, athocyanin and other components have been isolated from S. ebulus and identified as active ingredients of biological and pharmacological activities. Due to the easy collection of the plant and remarkable biological activities, this plant has become both food and medicine in the coastal area of Iran. This review presents comprehensive analyzed information on the botanical, chemical, toxico- pharmacological and clinical aspects of S. ebulus. Key words: Sambucus ebulus, Adoxaceae, RIPs, anti-inflammatory, anti-nociceptive, anti-cancer, anti- oxidative. INTRODUCTION Sambucus ebulus whose common name is dwarf elder, Iran and distributed in moist grasslands or forest margins elderberry or danewort, is a native perennial herb of the on Northern coast of Caspian Sea, Iran (Azadbakht, Adoxaceae family in the order of the Dipsacales, that 1999).
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