CCB Annual Report 2014

2014 Annual Report Centre for Cancer Biology 2014 Annual Report Centre for Cancer Biology 2 Organisation 3 Alliance Partners Report 4 Centre for Cancer Biology Directors Report 6 Celebrating Our Strategic Alliance Laboratories 8 Acute Leukaemia Laboratory 10 Cell Signalling Laboratory 12 Cytokine Receptor Laboratory 14 Drug Discovery and Development Laboratory 16 Gastroenterology Research Laboratory 18 Gene Regulation Laboratory 20 Hepatitis C Virus Research Laboratory 22 Leukaemia Unit, Genetics and Molecular Pathology 24 Lymphatic Development Laboratory 26 Mast Cell Laboratory 28 Molecular Pathology Research Laboratory 30 Molecular Regulation Laboratory Centre for Cancer Biology 32 Molecular Signalling Laboratory An alliance between 34 Myeloma Research Laboratory SA Pathology and the University of South Australia 36 Neurovascular Research Laboratory SA Pathology 38 Translational Oncology Laboratory Frome Road, Adelaide South Australia 5000 40 Tumour Microenvironment Laboratory Australia 42 Vascular Biology and Cell Trafficking Laboratory T +61 8 8222 3422 F +61 8 8232 4092 44 ACRF Cancer Genomics Facility General Enquiries Ms Anna Nitschke 46 Publications Executive Assistant to Professor Angel Lopez [email protected] 51 Financial Highlights Postal Address 52 New Grants and Fellowships PO Box 14 Rundle Mall Adelaide South Australia 5000 Publication Coordination 54 Seminar Program Australia Anna Nitschke Centre for Cancer Biology 56 Invited Presentations www.centreforcancerbiology.org.au Design and Production Catherine Buddle 58 Awards Buddle Design 60 Research Staff and Students cover image Photography Mark Fitz-Gerald and Peter Dent Sagittal section of an E7.0 embryo surrounded by yolk sac and endometrial tissue SA Pathology Photo & Imaging 62 Our Supporters immunostained to recognise Neuropilin 2 (red), E-cadherin (green) and DAPI (blue). Catherine Leo Neuropilin 2 recognises primitive mesoderm that gives rise to the haematopoetic 63 Supporting Our World Class Research lineage of the embryo. University of South Australia Organisation Vice Chancellor Executive Director and President SA Pathology UniSA Mr Ken Barr Professor David G Lloyd Mr Ken Barr Professor David Lloyd Alliance Partners Report It gives me great pleasure to present the fifth Annual Report My research career was in cancer drug discovery so I Co-Director Co-Director Operations Centre for Centre for of the Centre for Cancer Biology (CCB) of SA Pathology and automatically had a soft spot for the Centre for Cancer Biology. Manager Cancer Biology Cancer Biology to reflect on its successes in 2014. Partnerships are at the heart of everything we do and when the Mr Professor Professor opportunity came for the University of South Australia and the Russell D’Costa The CCB Alliance was formalised between SA Health and the Angel Lopez Sharad Kumar South Australian Department of Health, through SA Pathology, University of South Australia coming in to full effect in 2014 to to form an alliance to give long-term support and appropriate support and promote the growth of the CCB and its impressive ongoing research contributions to the health of the community. infrastructure to the Centre for Cancer Biology, we jumped at it. The CCB Alliance is an example of organisational synergy already This is an opportunity not only to promote and support medical Gastroenterology Acute Leukaemia Cell Signalling Drug Discovery delivering results and going from strength to strength, particularly research, but by linking theory with practice, we are also able to Cytokine Receptor Research Laboratory Laboratory and Development Laboratory Laboratory in the dynamic genomics arena. For instance I am delighted to maximise the resources and put the value of our discoveries Laboratory Professor Assoc Professor see the significant external competitive funding (NCRIS) that was Professor Assoc Professor directly into the delivery of quality health care services. Richard D’Andrea Yeesim Professor Angel Lopez Andrew obtained in 2014 to boost the ACRF Genomics Facility of the Khew-Goodall Shudong Wang Assoc Professor Ruszkiewicz The University’s health and biomedical research concentration, Ian Lewis CCB. our education and research concerning the prevention, diagnosis The CCB Alliance is already leading to better patient care and the and treatment of health problems, is a great fit for SA Health, and ACRF Cancer Genomics Facility of the CCB is a prime example together with the CCB we can maximise our contributions to the of the direct patient benefits derived from a close integration of Hepatitis C Virus Leukaemia Unit, Lymphatic Mast Cell health of the population. Gene Regulation Research Genetics and Development Laboratory high performance research and acute pathology services with Laboratory Laboratory Molecular Pathology Laboratory Together UniSA and CCB enhance each other’s efforts. The Assoc Professor several new disease genes discovered during 2014 including Professor Assoc Professor Assoc Professor Assoc Professor Michele CCB is focused on a range of cancers, providing research and Greg Goodall those responsible for cancer predisposition syndromes. In Michael Beard Susan Branford Natasha Harvey Grimbaldeston addition, the close integration of research and services brings support for personalised DNA targeted treatments which are South Australia to the national forefront in gaining formal NATA revolutionising cancer treatment and recovery. The alliance accreditation to implement diagnostic testing using exome with CCB complements UniSA’s expertise in the quality use sequencing and related techniques. of medicines, pharmaceutical science and pharmacokinetics research and also links with the University’s advanced Molecular Pathology Molecular Regulation Molecular Signalling Myeloma Research Neurovascular I would also like to acknowledge the recognition of the CCB manufacturing capabilities in nanotechnology and coatings Research Laboratory Laboratory Laboratory Laboratory Research by the South Australian public as a high performing medical Laboratory and with our technological leadership in the new CRC for Cell Professor Professor Professor Professor research institute which continues to attract philanthropic Hamish Scott Sharad Kumar Stuart Pitson Andrew Zannettino Dr Quenten Schwarz Therapy Manufacture. support. In particular, we are very grateful to the donors and the RAH Research Fund for their generosity and hard work not only Between our two organisations we embody a cancer research on behalf of the CCB but on behalf of medical research generally. community of enormous depth and capacity. We’re particularly proud of the two scientists who are driving the alliance. CCB In breaking news as this Annual Report goes to print, the latest Co-Directors Professors Angel Lopez and Sharad Kumar have Vascular Biology exciting development is the admission of the CCB to the Translational Tumour and contributed greatly to medical research throughout their careers. Oncology Laboratory Microenvironment ACRF Australian Association of Medical Research Institutes (AAMRI). Cell Trafficking Laboratory Cancer Genomics Both are Fellows of the Australian Academy of Science and, Professor This national recognition of the CCB as a medical research Assoc Professor Facility in 2014, were elected as Fellows to the Australian Academy of Michael Brown Dr Michael Samuel Claudine Bonder institute enhances the growth and innovation opportunities for Health and Medical Sciences. This is a new organisation created the CCB Alliance as new partnerships emerge in the evolving to promote health and medical research and its translation to health and biomedical research precinct. In an Australian and enable a healthy community in Australia and the world. global climate of constrained funding for health economies, we cannot underestimate the benefits and value that will derive It is due recognition of their potential to make a significant from partnerships between health delivery units, Universities contribution to better understanding cancer, improving its and medical research institutes. Together, these partnerships treatment and perhaps leading to a cure. We are especially represent a new model of sustainability and growth, which proud to be part of that. will underpin high-quality medical research. Professor David G Lloyd Mr Ken Barr Vice Chancellor and President Executive Director, SA Pathology The University of South Australia Executive Report 3 Professor Angel Lopez Professor Sharad Kumar Professor Jim McCluskey, keynote speaker at the CCB 2014 AGM Professor Professor David Lloyd presents opening remarks at the launch of CCB’s alliance with SA Health and UniSA We are pleased to report that in 2014 both of us were elected as to innovative projects and to accelerate the application of CCB Centre for Cancer Biology Directors Report Fellows of the newly created Australian Academy of Health and discoveries. We also continue to be active participants in the Professor Angel Lopez MBBS PhD FRCPA FAA FAHMS Medical Science, an honor that reflects the high performance of Cooperative Research Centre for Cell Therapy Manufacturing Professor Sharad Kumar MSc PhD FAA FAHMS the CCB and also represents an opportunity for us to promote in which the research led by Associate Professor Claudine and advance our younger CCB colleagues. In May the Program Bonder is a major focus. Grant led by Professors Lopez, Parker (St Vincent’s Institute of In advancing our vision, the CCB has a strong focus on women Medical Research) and Hughes

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