CCB Annual Report 2016

2016 Annual Report Centre for Cancer Biology 2016 Annual Report Centre for Cancer Biology 2 Organisation 3 Chairman's Report 4 Directors' Report 6 Bringing Cancer Genomics to South Australia Laboratories 8 Acute Leukaemia Laboratory 10 Cell Signalling Laboratory 12 Cytokine Receptor Laboratory 14 Drug Discovery and Development Laboratory 16 Gastroenterology Research Laboratory 18 Gene Regulation Unit 20 Gene Regulation in Cancer Laboratory 22 Gene Regulation Networks Laboratory 24 Inflammation and Human Ailments Laboratory 26 Leukaemia Unit, Genetics and Molecular Pathology 28 Lung Research Laboratory 30 Lymphatic Development Laboratory 32 Molecular Neurogenomics Research Laboratory 34 Molecular Pathology Research Laboratory 36 Molecular Regulation Laboratory 38 Molecular Signalling Laboratory 40 Myeloma Research Laboratory 42 Neurovascular Research Laboratory Centre for Cancer Biology 44 Translational Oncology Laboratory An alliance between SA Pathology and the 46 Tumour Microenvironment Laboratory University of South Australia 48 Vascular Biology and Cell Trafficking Laboratory SA Pathology 50 Viral Pathogenesis Research Laboratory Frome Road, Adelaide South Australia 5000 52 ACRF Cancer Genomics Facility Australia Postal Address 54 Outcomes for the Community PO Box 14 Rundle Mall 56 Publications Adelaide South Australia 5000 Australia 62 Financial Highlights T +61 8 8222 3422 63 New Grants and Fellowships F +61 8 8232 4092 66 Seminar Program E [email protected] 68 Invited Presentations www.centreforcancerbiology.org.au Publication Coordination Angela Ziaei 71 Awards Centre for Cancer Biology Design and Production 74 Service to the Community Catherine Buddle cover image 76 Research Staff and Students Buddle Design Mouse primary epididymal epithelial cells stained with antibodies to cytokeratin (green) and vimentin (red), and DAPI (blue). The image was captured using the Centre for Cancer Biology’s Photography (unless otherwise credited) 78 Our Supporters Leica STED microscope that is part of the ACRF Cancer Discovery Accelerator Facility. Mark Fitz-Gerald, Peter Dent and Peta Grant 79 Supporting Our World Class Research Photograph by Natalie Foot SA Pathology Photo & Imaging Organisation Centre for Centre for Cancer Biology Cancer Biology Strategic Liaison Scientific Committee Advisory Board The Honourable John Hill (SLC) (SAB) Chairman's Report Co-Director Co-Director Operations The Honourable John Hill Centre for Centre for Manager Cancer Biology Cancer Biology Former Member for Kaurna and former Minister for Health Mr Professor Professor Russell D’Costa Angel Lopez Sharad Kumar It is my pleasure to report on the progress of the Centre for Cancer Biology, its achievements and its plans for the future. The success of medical research institutes can be judged according to several criteria. The Directors have reported on the CCB’s outstanding success in attracting highly competitive medical research Gastroenterology funding, on publishing its research in the top medical research journals and on Acute Leukaemia Cell Signalling Drug Discovery Cytokine Receptor Research Laboratory Laboratory and Development Laboratory Laboratory developing new candidate drugs. A success rate in NHMRC Project and Fellowship Professor Assoc Professor Laboratory grants, about twice the national average, is truly exceptional. Professor Assoc Professor Richard D’Andrea Yeesim Professor Angel Lopez Andrew Khew-Goodall Shudong Wang This has also been an exciting year as the new Health Innovation Assoc Professor Ruszkiewicz These results cement our leading position in cancer research in Ian Lewis South Australia and nationally. The CCB is particularly fortunate Building approaches completion. A busy year of providing input to be in collaboration with both SA Health and the University of into the design and implementation of the new premises will South Australia and the benefits of this collaboration flow to all surely be rewarded when we move into the excellent new facilities in early 2018. Gene Regulation Leukaemia Unit, Lymphatic Mast Cell partners. Lung Research Unit Genetics and Development Laboratory Laboratory The relocation of the CCB to the Adelaide BioMed City precinct Molecular Pathology Laboratory In particular, the alliance between SA Health and the University Prof Greg Goodall Assoc Professor Professor will foster collaboration with SAHMRI and with University of Dr Philip Gregory Assoc Professor Assoc Professor Michele of South Australia uniquely positions the CCB to improve the Paul Reynolds Dr Cameron Bracken Susan Branford Natasha Harvey Grimbaldeston health of the SA community. The CCB’s research is strongly Adelaide researchers. The proximity to the new Royal Adelaide focused through the lens of practical benefit to patients. Several Hospital will re-invigorate the strong tradition of collaboration research leaders within the CCB are pathologists, senior with RAH clinicians. It is widely recognised that medical research scientists providing pathology services, or are actively practicing is best done in a ‘bench to bedside’ effort that needs close clinical specialists. CCB researchers have a strong track record interaction between researchers and clinicians. The CCB grew Molecular Molecular Regulation Molecular Signalling Myeloma Research in developing tests that identify cancer predisposing genes and out of such a collaborative culture, has enhanced that culture, Neurogenomics Molecular Pathology Laboratory Laboratory Laboratory Research Laboratory Research Laboratory that can differentiate between similar looking cancers responding and seeks to continue to grow the culture. I’m also confident Professor Professor Professor that the collaborative spirit of the CCB will contribute to bringing Assoc Professor Professor differently to treatment. The early identification of cancer risks Hamish Scott Sharad Kumar Stuart Pitson Andrew Zannettino Leanne Dibbens and differential diagnoses guides the choice of optimal all of the partners in the new precinct closer together to make therapeutic regimens. Adelaide BioMed City the vibrant medical research environment that is so strongly promoted by the Government of SA. I’m particularly pleased to see that our ACRF Cancer Genomics Facility, supported by major equipment grants from the Australian In closing I would like to congratulate the whole of the CCB Tumour Vascular Biology Viral Pathogenesis Cancer Research Foundation and the Government of South for its achievements this year which will put us in good stead Neurovascular Translational Microenvironment and Research for further success in the future. Research Oncology Laboratory Australia, is a national leader in the development and application Laboratory Cell Trafficking Laboratory Laboratory Professor of these technologies to the benefit of South Australian patients. The Honourable John Hill Assoc Professor Assoc Professor Assoc Professor Dr Quenten Schwarz Michael Brown Michael Samuel Claudine Bonder Michael Beard In 2016 the CCB’s Scientific Advisory Board, Chaired by Professor Ian Frazer AC, reported very positively on the CCB’s science, and made important suggestions to help develop the CCB further and achieve wider recognition in the community. Inflammation and It is satisfying to see many of these recommendations crystallized Human Ailments in our five year Strategic Plan that sets the CCB's course for Laboratory ACRF ACRF Cancer Genomics Cancer Discovery the future. It has also been satisfying to participate at the annual Prof Vinay Tergaonkar Facility Accelerator meeting of the Australian Association of Medical Research Assoc Professor Institutes (AAMRI) in Canberra, in a year when the advent of the Simon Conn Medical Research Future Fund opens exciting new possibilities and the opportunity for us to be active participants in the new national funding landscape. 2 Centre for Cancer Biology Annual Report 2016 Report from the Chair 3 Professors Angel Lopez and Sharad Kumar Keynote speaker Professor Suzanne Cory AC PhD FAA FRS Foreground structures, looking south-west across the River Torrens: Adelaide Festival Centre, Adelaide Convention Centre and Riverbank Promenade, and cranes atop the Health Innovation Building that will house the Centre for Cancer Biology. Photograph courtesy BVN & Swanbury Penglase Architects As a consequence of the Strategic Plan the CCB has formalised In seeking synergies and collaborations we continue to work Directors' Report a mentorship group led by Professors Greg Goodall and Stuart closely with the Institute of Molecular and Cellular Biology Professor Angel Lopez AO MBBS PhD FRCPA FAA FAHMS Pitson who will help to develop our young talented researchers. (IMCB) in Singapore through Professors Wanjin Hong and Vinay Professor Sharad Kumar MSc PhD FAA FAHMS Similarly, we have instituted a Consumer Advocacy Group, led by Tergaonkar and the Joint IMCB-CCB Laboratory, with SAHMRI, Associate Professor Claudine Bonder, which seeks to bring the the Children's Cancer Institute, and the Peter MacCallum Cancer As we write this report we can see with anticipation the changes to the skyline at the CCB closer in touch with the needs and expectations of cancer Centre. A visit by the CCB to the Peter MacCallum Cancer patients. Centre in November identified clear areas of synergy which western end of North Terrace where the new Adelaide BioMed City Precinct is taking have already led to joint project grant applications and places As a member of the Association of Australian Medical Research shape. Prominent

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