(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date i 29 September 2011 (29.09.2011) WOk 2U1 1/1 16432 Al

(51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CI2Q 1/68 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, PCT/AU201 1/000349 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 28 March 201 1 (28.03.201 1) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (26) Publication Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 2010901300 26 March 2010 (26.03.2010) (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): BOND GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, UNIVERSITY LTD [AU/AU]; Bond University, Gold ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, Coast, Queensland 4229 (AU). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors; and LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (75) Inventors/ Applicants (for US only): MARSHALL- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GRADISNIK, Sonya Maree [AU/AU]; 54 Harwood GW, ML, MR, NE, SN, TD, TG). Road, Burringbar, New South Wales 2483 (AU). GRAY, Bon [AU/AU]; 218 Woodlands Drive, Thornlands, Published: Queensland 4164 (AU). TAJOURI, Lotti [FR/AU]; 100 — with international search report (Art. 21(3)) Henry Cotton Drive, Parkwood, Queensland 4214 (AU). (74) Agent: PIZZEYS PATENT & TRADE MARK AT¬ TORNEYS; Level 20, 324 Queen Street, (GPO Box 1374), Brisbane, QLD 4000 (AU).

(54) Title: METHODS AND COMPOSITIONS FOR DETECTING BANNED SUBSTANCES (57) Abstract: The present invention relates to methods and compositions thereof for detecting banned substances and doping agents. The present invention further relates to measurement of expression to detect doping events such as the use of recom binant human Growth Hormone (rhGH). Methods for Detection of Doping and Compositions Thereof

Field of the Invention

The present invention relates to methods and compositions thereof for detecting substances administered to the body. The present invention further relates to measurements of gene expression to detect doping events such as the delivery of a prohibited exogenous substance like recombinant human growth hormone (rhGH) into the body.

Background

It is thought that many substances such as growth hormone (GH) and in particular rhGH have been ubiquitously used by professional athletes predominantly since about the early to mid 1980s to enhance their athletic performance (McHugh et al., 2005). However, such a substance has been banned for many, many years. rhGH is an "officially" banned substance as it is present on the World Anti-Doping Agency list of banned agents/substances. Two actions of GH are considered beneficial to athletes and their performance. One is anabolic and the other lipolytic. The effects are (i) an increase in lean body mass and

(ii) a reduction in fat mass. In regards to the anabolic component of GH, some of the action is mediated via the production of insulin-like growth factor-l (IGF-I). The regulation of synthesis involves the synergistic actions of GH and IGF-I stimulating protein synthesis. It has been found that GH stimulates protein synthesis via a mechanism that is different to the mechanism triggered by anabolic steroids and therefore it seems likely that their effects if taken together will be at least additive if not synergistic. This has resulted in numerous athletes combining at least GH and anabolic steroids and possibly insulin as well

(Sonksen, 2001). It is estimated that GH doses used by athletes are about up to 10 times higher than those used by endocrinologists in treating various growth-related disorders or abnormalities. It is evident that athletes that take such a high dose are putting themselves at risk of contracting various conditions such as hypertension, diabetes and Creutzfeldt-Jakob disease.

In the anti-doping community, the detection of GH is by far the greatest modern challenge today.

The detection of GH abuse has proved difficult for many reasons. Unlike many abused substances, e.g. synthetic anabolic steroids, GH is a naturally occurring protein in the body. As such, a method of detecting

GH doping must be able to identify levels of GH that are above normal physiological levels of GH while excluding pathological conditions that involve high levels of GH such as acromegaly. Further, the detection of GH is a "moving target" as routine exercise and stress are predominant stimulators of GH production (Prinz et al., 1983; Savine and Sonksen, 2000). Consequently, natural GH concentrations are often at their highest in the immediate post-competition setting when most drug testing occurs. However, recombinant human GH is almost identical to pituitary GH. Cadaveric GH, which can purchased on-line, is indistinguishable to endogenously produced GH. Less than 0.1% of GH and IGF-I is excreted and even that is erratic, thus rendering urine testing unreliable and unfeasible (Moreira-Andres et al., 1993).

Endogenously secreted GH has a half-life of approximately 13 min (Sohmiya and Kato, 1992) which is expeditiously cleared from the body by such organs as the liver and the kidney but also by peripheral tissues. Recombinant human GH (rhGH) has a similar half-life as endogenously secreted GH if rhGH is intravenously administered (Refetoff and Sonksen, 1970; Haffner et al., 1994).

However, the preferred route of administration of exogenous GH is via daily, subcutaneous injection. Following injection, plasma GH concentrations increase and reach a maximum concentration after about 2-6 hours (Kearns et al., 1991; Janssen et al., 1999). Soon thereafter, rhGH is quickly cleared from the body. In fact, GH is routinely undetectable in women 12 hours after injection, whilst men have only low levels of GH. (Giannoulis et al., 2005).

There are two current methods for detection of GH doping which are World Anti-Doping Agency

(WADA)-approved blood tests. One is predicated on the detection of different pituitary GH isoforms, whilst the second method involves measurement of GH-dependent markers. In the first method, it is acknowledged that GH exists as multiple isoforms; 70% of circulating GH is in the form of a 22-kilo Dalton

(kDa) polypeptide, whereas 5-10% occurs as a 20 kDa isoform due to mRNA splicing. It is also acknowledged that dimers and oligomers of GH exist as well as acidic, desaminated, acylated and fragmented forms (Baumann, 1999). This method is predicated on the theory that endogenous GH occurs as a number of isoforms whilst, in contrast, rhGH contains only the 22 kDa isoform. It has been found that a suppression of endogenous GH secretion through negative feedback to the pituitary occurs when rhGH is administered in sufficiently high doses. In effect, the ratio between 22 kDa GH and non-22 kDa GH increases (Bidlingmaier et al., 2003).

The second method concerns the specific measurement of either the 22 or 20 kDa GH (Momomura et al., 2000) which is predicated on the principle that the ratio between 22 kDa and total GH is less than 1 with a normal distribution of values, whereas individuals receiving GH have values that are greater than one (Wu et al., 1999). However, it has been found that exercise causes a transient relative increase in the

22 kDa isoform, thereby lowering the sensitivity of the test if samples are taken immediately after competition (Wallace et al., 2001a, b).

It is known that the half-life of rhGH is short and the clearance is quick when injected subcutaneously but even shorter and quicker when injected intravenously. As such, the time frame of detecting GH doping is approximately less than 36 hours after last administration of exogenous GH (Keller et al., 2007). Since GH is usually administered in the evening, GH is often undetectable in a blood sample obtained the following day (Giannoulis et al., 2005). In women, the 20 kDa GH remains suppressed for approximately 14-30 hours whilst in men, 20 kDa GH remains undetectable for up to 36 hours (Keller et al.,

2007). Spontaneous GH secretion, such as secretion of the 20 kDa GH, returns 48 hours subsequent to the last dose of rhGH administration (Wu et al., 1990). As a consequence, any athlete who terminates administration of GH at least two days prior to a competition will not be detected. Taken together, neither of the two methods described above would likely detect doping with exogenous GH e.g. rhGH in a classical 'post competition' dope testing scenario. The only scenario that may yield results from the two methods described above is via unannounced 'out of competition' testing which is inconvenient and insufficient.

In light of the above, it is apparent that a long, felt need as existed for a method that detects doping with exogenous GH when last administration was at least several days if not weeks before competition.

Such a method would be advantageous over the current methods on the basis that such a method would not be limited to unannounced 'out of competition' testing to achieve effectiveness. Until now, such a method has remained elusive.

The present invention is predicated on the surprising discovery that the measurement of gene expression in one or more endogenous that are affected by the presence of a substance that has been exogenously delivered such as rhGH allows for the reliable detection of such a substance beyond the window of time available from commercial tests and kits.

Summary

There is provided herein a method for detecting administration of a substance to a subject wherein the method comprises:

(a) obtaining a biological sample from the subject; and

(b) analyzing the biological sample to determine expression levels of one or more genes wherein change in one or more said expression levels of the one or more genes in the biological sample, when compared to a control sample, is indicative of administration of the substance to the subject.

There is provided herein a method for screening one or more biological samples from one or more subjects to determine whether a substance was administered to the one or more subjects, wherein the method comprises:

(a) obtaining the one or more biological samples from the one or more subjects; and

(b) analyzing the one or more biological samples to determine expression levels of one or more genes wherein change in the expression levels of the one or more genes in the one or more biological samples, when compared to a control sample, is indicative of administration of the substance to the one or more subjects.

In one embodiment, the substance is an antagonist or agonist. In another, the substance is an anabolic agent, a hormone, a hormone antagonist, a hormone modulator, a growth factor, a beta-2 agonist, a diuretic, a masking agent, a stimulant, a narcotic, a cannabinoid, a glucocorticosteriod, or a beta-blocker. In a further, the substance is a growth hormone, insulin-like growth factor (IGF-1), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), mechano growth factor (MGF), platelet-derived growth factor (PDGF), vascular-endothelial growth factor (VEGF). A growth hormone may be for example a recombinant human growth hormone (rhGH).

In yet another embodiment, expression levels can be determined by quantifying transcriptional products of the one or more genes. In a non-limiting example, the transcriptional products are RNA, such as, mRNA, microRNA, ribosomal RNA and/or ds RNA. The transcriptional products can be quantified by using, for example, rolling-circle replication.

In another embodiment, expression levels can be determined by quantifying translational products resulting from the transcriptional products of the one or more genes. In a non-limiting example, the translational products may be polypeptides and/or protein. The translational products can be quantified by using, for example, an ELISA technique.

According to another aspect of the invention, there is provided one or more isolated genes when detected by the methods according to the above aspects. In a non-!imiting example, the one or more genes may be selected from the group of genes listed in Tables 1 to 4 and as shown in Figures 1 to 10. In a further embodiment, an isolated gene may be WFIKKN2.

According to a further aspect of the invention, there is provided one or more translational products and/or one or more transcriptional products of the one or more isolated genes of the third aspect. In an embodiment, a translational product may be GASP-1 .

According to another aspect of the invention, there is provided use of one or more genes for detecting administration of a substance to a subject wherein the use comprises:

(a) obtaining a biological sample from the subject; and

(b) analyzing the biological sample to determine expression levels of the one or more genes

wherein change in one or more the expression levels of the one or more genes in the biological sample, when compared to a control sample, is indicative of administration of the substance to the subject. According to another aspect of the invention, there is provided use of one or more genes for screening one or more biological samples from one or more subjects to determine whether a substance was administered to the one or more subjects, wherein the use comprises:

(a) obtaining the one or more biological samples from the one or more subjects; and

(b) analyzing the one or more biological samples to determine expression levels of the one or more genes

wherein change in the expression levels of the one or more genes in the one or more biological samples, when compared to a control sample, is indicative of administration of the substance to the one or more subjects.

According to another aspect of the invention, there is provided use of one or more compounds to determine administration of a substance to a subject, wherein the use comprises:

(a) obtaining a biological sample from the subject; and

(b) measuring one or more expression levels of one or more genes with the one or more compounds by quantifying a number of transcriptional and/or translational products of the one or more genes; and

wherein change in the number of transcriptional and/or translational products of the one or more genes in the biological sample, when compared to a control sample, is indicative of administration of the substance to the subject.

In one embodiment, the one or more compounds may be one or more polynucleotides and/or one or more polypeptides. The one or more polynucleotides may encode the one or more polypeptides. The one or more polypeptides may comprise a full-length and/or wild-type sequence of one or more translational products. The one or more polypeptides may be a recombinant, variant, analogue, derivative or fragment of one or more transcriptional products encoded by one or more genes listed in Tables 1 to 4 and as shown in Figures 1 to 10. The one or more polypeptides may bind directly or indirectly to one or more translational products according to the fourth aspect. Analysis may be quantitative, qualitative, semi¬ quantitative or semi-qualitative. Quantification of the one or more translational products may be determined by an immunoassay for example. An example of an immunoassay that may be used to quantify the one or more translational products is, but not limited to, GC-MS, IRMS, flow cytometry, an enzyme-linked immunoassay, a radioimmunoassay, or an immunoassay comprising a biosensor.

In another embodiment, the one or more polynucleotides are present in an expression construct.

The one or more polynucleotides may be operably linked to a promoter. In yet another embodiment, a host cell may be transformed with the expression construct. In a further embodiment, there is provided an antibody that selectively binds to the one or more polypeptides. The antibody and/or one or more polypeptides may be tagged, for example, with chemical-based, fluorescence-based or photo-based tags.

In another aspect of the invention, there is provided a kit when used for detecting administration of a substance to a subject, wherein the kit comprises means for analysing a biological sample obtained from the subject to determine expression levels of one or more genes wherein change in the one or more expression levels of the one or more genes in the biological sample, when compared to a control sample, is indicative of administration of the substance to the subject.

In a further aspect of the invention, there is provided a kit when used for screening one or more biological samples from one or more subjects to determine whether a substance was administered to the one or more subjects, wherein the kit comprises means for analyzing the one or more biological samples to determine expression levels of one or more genes wherein change in the expression levels of the one or more genes in the one or more biological samples, when compared to a control sample, is indicative of administration of the substance to the one or more subjects.

In one embodiment of the above aspects, the change in expression levels of the one or more genes may be detected about one week from the last administration of exogenous GH. The change may be detected about 8 days from last administration. The change may be detected greater than about two weeks from last administration. The change may be detected about 15 days from last administration. The change may be detected greater than about three weeks from last administration. The change may be detected about 22 days from last administration. The change may be detected greater than about four weeks from last administration. The change may be detected about 29 days from last administration.

In another embodiment, the expression levels of one or more genes may increase between the day of the last administration (day 0) and day 8, 15, 22 or 29. The expression levels of one or more genes may increase between day 8 and day 15, 22 or 29. The expression levels of one or more genes may increase between day 15 and day 22 or 29. The expression levels of one or more genes may increase between day 22 and day 29. In another embodiment, the one or more genes may be selected from the group comprising the genes listed in Table 1. In a further embodiment, the one or more genes may be selected from the group comprising HS.123362, HS.148699, LOC728763, OR10K2, LRRC10, WFIKKN2,

LOC652139, HS.543090, HS.439050, LOC284428, ARHGAP29, GPR111, HS.544930, LOC647582,

HS.566552, OR52B2, LOC653225, FBX017, HS.121775, LOC646484, SPEM1, HS.163781, MGC39606,

HS.147255, CDC42BPG, LRIT2, FMR1NB, HS.545435, INSL6, GLRA2, OR13J1, HS.568640,

LOC653412, HS.538738, SLC36A2, HSD17B2, S100A7, OR51B6, HS.560015, HS.543248, C40RF28,

LOC644431, CHRND, CYP2W1, HS.563770, HS.543479, LRP4, HS.570624, HS.570433, LOC650568,

HS.544526, CHRNB2, HS.541735, HS.469608, HS.1 19816, HS.575834, ATP4A, PCDHB12, OR1I1, HS.554090, HS.97443, HS.277205, HS.539654, HS.156470, KCNQ5, MGC16291, LOC651655, ZNF678 and MT1 M . In yet a further embodiment, the one or more genes is WFIKKN2.

In another embodiment, the expression levels of one or more genes may decrease between the day of the last administration (day 0) and day 8, 15, 22 or 29. The expression levels of one or more genes may decrease between day 8 and day 15, 22 or 29. The expression levels of one or more genes may decrease between day 15 and day 22 or 29. The expression levels of one or more genes may decrease between day 22 and day 29. In yet another embodiment, the one or more genes may be selected from the group comprising the genes listed in Table 2. In a further embodiment, the one or more genes may be selected from the group comprising HS.1 54607, LOC64581 1, NFATC2, HS.559868, HS.566874,

HS.568234, LOC645004, HS.551381, TCEAL6, RUNDC3A, HS.567081, DEFB103A, SLC2A7,

HS.584074, HS.1 95726, FLJ35848, HMX3, HS.563829, HS.575043, LOC642660, LOC642425,

HS.559957, HS.44210, HS.5381 12, LOC439985, FAM154B, HS.5531 19, SLC38A4, HS.551291,

HS.147007, LOC647869, LOC440570, HS.51 1485, HS.543820, KRTHA5, HS.582854, HS.580142,

HS.1 20542, LOC652437, HS.562048, SST, HS.540137, LOC645953, HS.552808, HS.580377,

LOH3CR2A, CRTAC1, HS.564724, HS.576427 and LOC642140.

In one embodiment, exogenous GH may be recombinant human GH or cadaveric GH or any other non endogenous GH that is administrable.

The biological sample may be selected from the group comprising a bodily fluid or tissue. The bodily fluid or tissue may comprise blood, serum, plasma, lymph, thymus, lymph node, spleen, bone marrow, muscle or tonsil. In one embodiment, the biological sample is a blood sample. Plasma may be collected from the blood.

Peripheral blood mononuclear cells (PBMCs) may be isolated from the plasma. In one embodiment, the expression levels of one or more genes may be determined by quantifying transcriptional products that are inside the peripheral blood mononuclear cells (PBMCs). The transcriptional products may be, for example encoded by any one or more genes listed in Tables 1 to 4 and Figures 1 to 10. In a further embodiment, RNA such as mRNA, microRNA and/or ribosomal RNA may be collected from PBMCs and analysed to determine change in gene expression whereby the change is indicative of exogenous GH administration. In yet another embodiment, expression levels of translational products encoded by the transcriptional products described herein are also contemplated. These translational products may be and/or polypeptides. These proteins and/or polypeptides may be secreted from one or more

PBMCs and may enter the non cellular matrix of the plasma.

The control sample may comprise a biological sample from one or more subjects who have not been administered exogenous GH. For the purposes of the above aspects and embodiments, the subject may be a human or any other animal. In particular embodiments the subject is selected from the group consisting of human, non-human primate, equine, bovine, ovine, caprine, leporine, avian, feline and canine.

Definitions

In the specification and the claims the term "comprising" shall be understood to have a broad meaning similar to the term "including" and will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps. This definition also applies to variations on the term "comprising" such as "comprise" and

"comprises"

The term "expression" as used herein refers interchangeably to expression of a gene or gene product, including the generation of RNA transcripts (e.g. messenger RNA [mRNA]) and/or the generation of polypeptide or protein encoded by the RNA transcripts. Expression of a gene product may be determined, for example, by immunoassay using an antibody(ies) that bind with the polypeptide.

Alternatively, expression of a gene may be determined, for example, by measuring mRNA levels.

Techniques used to measure expression may be quantitative, qualitative, semi-quantitative or semi- qualitative.

The term "change in expression levels" as referred to herein means the number of transcriptional and/or translational products of a gene or gene(s) has either decreased or increased between at least two given time points. The term "up-regulated" as used herein means the increase of expression of a gene or gene product, including the encoded polypeptide or protein from one point in time to a subsequent point in time. The term "incremental" as used herein means step-wise increase or up-regulation in gene expression over two or more time points. The term "down-regulated" as used herein has a reciprocal meaning to the term "up-regulated". The term "decremental" as used herein means step-wise decrease or down-regulation in gene expression over two or more time points. Change can be detected, for example, by qualitative, quantitative, semi-quantitative or semi-qualitative means. A point in time means a time point in which gene expression is quantified and/or qualified. As described herein, a time point can be denoted by "Tp...", "wk...", "wk...Z" and/or "day..." and are taken to have equal and corresponding meanings and representations. These denotations can be used interchangeable. In one example, time point 1 or "Tp1" has the same meaning as "wk 1", "wk 1Z", "Z1" and "day 8". This time point represents expression levels on day 8 as compared to the baseline at day 0 . In another example, time point 2 or "Tp2" has the same meaning as "wk 2", "wk 2Z", "Z2" and "day 15". This time point represents expression levels on day 15 as compared to the baseline at day 0. In yet a further example, time point 3 or "Tp3" has the same meaning as "wk 3", "wk 3Z", "Z3" and "day 22". This time point represents expression levels on day 22 as compared to the baseline at day 0 . Yet still, time point 4 or "Tp4" has the same meaning as "wk 4", "wk

4Z", "Z4" and "day 29". This time point represents expression levels on day 29 as compared to the baseline at day 0.

The term "substance" as used herein means any compound, regardless of its purity and stereochemistry, that has an effect on the human body when administered to the body by any route. The compound can be, for example, agonists, antagonists, modulators, suppression, activators. The compound is detected by the method of the invention. The method is genomic or proteomic based. The substance could be a prohibited substance as per the 201 1 Prohibited List - International Standard as published on 18 September 2010 and maintained by the World Anti-Doping Agency. Non-limiting examples of such a substance could be substances that are anabolic agents such as exogenous anabolic androgenic steroids (AAS) including, but not limited to 1-androstenediol (5a-androst-1-ene-33,173-diol); 1- androstenedione (5a-androst-1-ene-3,17-dione); (19-norandrostenediol); bolasterone; boldenone; boldione (androsta-1,4-diene-3,17-dione); calusterone; clostebol; (17a-ethynyl-17p- hydroxyandrost-4-eno[2,3-d]isoxazole); dehydrochlormethyltestosterone (4-chloro-1 73-hydroxy-1 7a- methylandrosta-1 ,4-dien-3-one); desoxymethyltestosterone ( 17a-methyl-5a-androst-2-en-1 7β-ο Ι); drostanolone; (19-nor-17a-pregn-4-en-17-ol); fluoxymesterone; formebolone; furazabol (17β- hydroxy-17a-methyl-5a-androstano[2,3-c]-furazan); ; 4-hydroxytestosterone (4,17β- dihydroxyandrost-4-en-3-one); mestanolone; mesterolone; metenolone; methandienone (17p-hydroxy-

17a-methylandrosta-1,4-dien-3-one); methandriol; methasterone (2a, 17a-dimethyl-5a-androstane-3-one-

17β-ο Ι); (^-hydroxy-17a-methylestra-4,9-dien-3-one); methyl-1 -testosterone (17β- hydroxy-17a-methyl-5a-androst-1-en-3-one); methylnortestosterone (^-hydroxy-17a-methylestr-4-en-3- one); methyltestosterone; (methyltrienolone, 17 - ydroxy-17a-methylestra-4,9,1 1-trien-3- one); ; ; 19-norandrostenedione (estr-4-ene-3,17-dione); norboletone; norclostebol; ; oxabolone; oxandrolone; oxymesterone; oxymetholone; prostanozol (^-hydroxy-5a- androstano[3,2-c] pyrazole); quinbolone; stanozolol; stenbolone; 1-testosterone (^-hydroxy-5a-androst-

1-en-3-one); (18a-homo-pregna-4,9,1 1-trien-^-ol-3-one); ; and other substances with a similar chemical structure or similar biological effect(s). Other examples of AAS are endogenous AAS which are administered exogenously such as androstenediol (androst-5-ene^,^- diol); androstenedione (androst-4-ene-3,17-dione); dihydrotestosterone (^-hydroxy-5a-androstan-3- one); prasterone (dehydroepiandrosterone, DHEA); testosterone including the following metabolites and isomers: 5a-androstane-3a,17a-diol; 5a-androstane-3a,^-diol; 5a-androstane^,17a-diol; 5a- androstane-3p,17p-diol; androst-4-ene-3a,17a-diol; androst-4-ene-3a,17p-diol; androst-4-ene-33,17a-diol; androst-5-ene-3a,17a-diol; androst-5-ene-3a,173-diol; androst-5-ene-33,17a-diol; 4-androstenediol

(androst-4-ene-3p, 17p-diol); 5-androstenedione (androst-5-ene-3, 7-dione); epi-dihydrotestosterone; epitestosterone; 3a-hydroxy-5a-androstan-1 7-one; 3p-hydroxy-5a-androstan-1 7-one; 19-norandrosterone and19-noretiocholanolone. Other anabolic agents, including but not limited to clenbuterol, selective androgen modulators (SARMs), , zeranol, zilpaterol. The term substance may include peptide hormones, growth factors and related substances. They include Erythropoiesis-Stimulating

Agents [e.g. erythropoietin (EPO), darbepoetin (dEPO), hypoxia-inducible factor (HIF) stabilizers, methoxy polyethylene glycol-epoetin beta (CERA), peginesatide (Hematide)]; Chorionic Gonadotrophin (CG) and

Luteinizing Hormone (LH) in males; Insulins; Corticotrophins; Growth Hormone (GH), Insulin-like Growth

Factor-1 (IGF-1), Fibroblast Growth Factors (FGFs), Hepatocyte Growth Factor (HGF), Mechano Growth

Factors (MGFs), Platelet-Derived Growth Factor (PDGF), Vascular-Endothelial Growth Factor (VEGF) as well as any other growth factor affecting muscle, tendon or ligament protein synthesis/degradation, vascularisation, energy utilization, regenerative capacity or fibre type switching; and other substances with similar chemical structure or similar biological effect(s); beta-2 agonists; hormone antagonists and modulates such as Aromatase inhibitors including, but not limited to: aminoglutethimide, anastrozole, androsta-1,4,6-triene-3,1 7-dione (androstatrienedione), 4-androstene-3,6,17 trione (6-oxo), exemestane, formestane, letrozole, testolactone; Selective estrogen receptor modulators (SERMs) including, but not limited to: raloxifene, tamoxifen, toremifene; Other anti-estrogenic substances including, but not limited to: clomiphene, cyclofenil, fulvestrant.and agents modifying myostatin function(s) including, but not limited, to: myostatin inhibitors. Other substances could be diuretics and other masking agents such as, but not limited to diuretics, desmopressin, plasma expanders (e.g. glycerol; intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol), probenecid; and other substances with similar biological effect(s); Acetazolamide, amiloride, bumetanide, , chlorthalidone, etacrynic acid, furosemide, indapamide, metolazone, , thiazides (e.g. bendroflumethiazide, chlorothiazide, hydrochlorothiazide), triamterene; and other substances with a similar chemical structure or similar biological effect(s) (except drosperinone, pamabrom and topical dorzolamide and brinzolamide, which are not prohibited). Substances contemplated herein may be those that are part of a prohibitory method including, but not limited to, the method of (i) artificial enhancement of oxygen transfer (excluding supplemental oxygen), and (ii) gene doping. A substance may be a specific or non-specific stimulant. A non-specific stimulant could be, but not limited to, amfepramone; amiphenazole; amphetamine; amphetaminil; benfluorex; benzphetamine; benzylpiperazine; bromantan; clobenzorex; cocaine; cropropamide; crotetamide; dimethylamphetamine; etilamphetamine; famprofazone; fencamine; fenetylline; fenfluramine; fenproporex; furfenorex; mefenorex; mephentermine; mesocarb; methamphetamine(d-); p-methylamphetamine; methylenedioxyamphetamine; methylenedioxymethamphetamine; modafinil; norfenfluramine; phendimetrazine; phenmetrazine; phentermine; 4-phenylpiracetam (carphedon); prenylamine; prolintane. A specific stimulant may be, but not limited to, adrenaline; cathine; ephedrine; etamivan; etilefrine; fenbutrazate; fencamfamin; heptaminol; isometheptene; levmetamfetamine; meclofenoxate; methylephedrine; methylhexaneamine

(dimethylpentylamine); methylphenidate; nikethamide; norfenefrine; octopamine; oxilofrine; parahydroxyamphetamine; pemoline; pentetrazol; phenpromethamine; propylhexedrine; pseudoephedrine; selegiline; sibutramine; strychnine; tuaminoheptane; and other substances with a similar chemical structure or similar biological effect(s). Also, the substance may be a narcotic such as buprenorphine, dextromoramide, diamorphine (heroin), fentanyl and its derivatives, hydromorphone, methadone, morphine, oxycodone, oxymorphone, pentazocine, pethidine; or a cannabinoid such as natural (e.g. cannabis, hashish, marijuana) or synthetic delta 9-tetrahydrocannabinol (THC) and cannabimimetics [e.g.

"Spice" (containing JWH018, JWH073), HU-210]; or glucocorticosteriods when administered by oral, intravenous, intramuscular or rectal routes; or beta-blockers including, but are not limited to, acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol, carvedilol, celiprolol, esmolol, labetalol, levobunolol, metipranolol, metoprolol, nadolol, oxprenolol, pindolol, propranolol, sotalol, timolol.

The term "exogenous" as used herein means either (i) delivery of a substance into the body, or (ii) a substance that is manufactured outside the body and delivered thereto, or (iii) refers to a substance which is not ordinarily capable of being produced by the body naturally. The exogenous substance may be a substance as described and defined above. The exogenous substance may be identical or substantially similar to an endogenous substance.

The term "endogenous" refers to a substance which is capable of being produced by the body naturally. The substance may be as described and defined above.

The term "agonist" refers to a substance that activates one or more molecules in the body. The term "antagonist" refers to a substance that suppresses one or more molecules in the body. The substance may be as described and defined above.

The term "amino acid" as used herein means any molecule that contains both amine and carboxyl functional groups.

The term "polypeptide" means a polymer made up of amino acids linked together by peptide bonds.

The term "polypeptide" may constitute a portion of a full length protein. Further, the term "polypeptide" refers to a polypeptide that may exhibit at least one modification of its amino acid sequence, compared to a wild type molecule. The modification may include chemical modifications such techniques as ubiquitination, labelling (e.g., with radionuclides or various enzymes), covalent polymer attachment such as pegylation (derivatization with polyethylene glycol) and insertion or substitution by chemical synthesis of amino acids such as ornithine, which are naturally occurring in human proteins.

The term "polynucleotide" as used herein refers to a single- or double- stranded polymer of deoxyribonucleotide, ribonucleotide bases or known analogues of natural nucleotides, or mixtures thereof.

The term includes reference to the specified sequence as well as to the sequence complimentary thereto, unless otherwise indicated. The terms "polynucleotide" and "nucleic acid" are used interchangeably herein.

The term "isolated" means that the molecule in question has been removed from its natural environment or host, and associated impurities reduced or eliminated such that the molecule in question is the predominant species present (e.g., on a molar basis it is more abundant than any other individual species in the composition/sample). Typically a substantially purified fraction is a composition wherein the object species comprises at least about 30 percent of all macromolecular species present. Generally, a substantially pure composition will comprise more than about 80 to 90 percent of all macromolecular species present in the composition. Most typically, the object species is purified to essential homogeneity

(contaminant species cannot be detected in the composition by conventional detection methods) wherein the composition consists essentially of a single macromolecular species.

Brief Description of the Drawings

Figure 1. Graph showing transcriptional expression profiles of 14 genes which can be found listed in Table 1. These 14 genes showed consistent increases (i.e. up-regulated) over a 3 week period from time point 1 (i.e. week 1 (which can also be denoted as wk 1Z)) to time point 4 (i.e. week 4 (which can also denoted as wk 4Z).

Figure 2. Graph showing transcriptional expression profiles of 10 genes which can be found listed in Table 2 . These 10 genes showed consistent decreases (i.e. down-regulated) over a 3 week period from time point 1 (i.e. week 1) to time point 4 (i.e. week 4).

Figure 3. Graph showing 10 genes that display the highest incremental expression as compared to the expression by other genes between time point 1 (i.e. first week post injection) and baseline which resulted in increased Z scores (i.e. M+ values).

Figure 4. Graph showing 10 genes that display the highest decremental expression as compared to the expression by other genes between time point 1 (i.e. first week post injection) and baseline which resulted in decreased Z scores (i.e. M- values). Figure 5. Graph showing 10 genes that display the highest incremental expression as compared to the expression by other genes between time point 2 (i.e. second week post injection) and time point 1 (i.e. first week post injection) which resulted in increased Z scores (i.e. M+ values).

Figure 6. Graph showing 10 genes that display the highest decremental expression as compared to the expression by other genes between time point 2 (i.e. second week post injection) and time point 1 (i.e. first week post injection) which resulted in decreased Z scores (i.e. M- values).

Figure 7. Graph showing 10 genes that display the highest incremental expression as compared to the expression by other genes between time point 3 (i.e. third week post injection), time point 2 (i.e. second week post injection) and time point 1 (i.e. first week post injection) which resulted in increased Z scores (i.e. M+ values).

Figure 8. Graph showing 10 genes that display the highest decremental expression as compared to the expression by other genes between time point 3 (i.e. third week post injection), time point 2 and time point 1 (i.e. first week post injection) which resulted in decreased Z scores (i.e. M- values).

Figure 9. Graph showing 10 genes that display the highest incremental expression as compared to the expression by other genes between time point 4 (i.e. fourth week post injection), time point 3 (i.e. third week post injection), time point 2 (i.e. second week post injection) and time point 1 (i.e. first week post injection) which resulted in increased Z scores (i.e. M+ values).

Figure 10. Graph showing 10 genes that display the highest decremental expression as compared to the expression by other genes between time point 4 (i.e. fourth week post injection), time point 3 (i.e. third week post injection), time point 2 and time point 1 (i.e. first week post injection) which resulted in decreased Z scores (i.e. M- values).

Detailed Description

The current World Anti-Doping Agency (WADA)-approved blood test for the detection of rhGH is based on the isoform or differential immunoassay method as discussed above. The current method provides a "window of opportunity" for testing of less than 36 hours after administration of such a substance.

The present invention is predicated on the surprising discovery that the measurement of gene expression in one or more endogenous genes that are affected by an administered substance, such as exogenous GH, allows for the reliable detection of exogenous GH such as rhGH well beyond 36 hours. It is contemplated herein that the measurement of gene expression could be used to detect a substance, such as an exogenous substance like an antagonist or agonist; an anabolic agent, a hormone, a hormone antagonist, a hormone modulator, a growth factor, a beta-2 agonist, a diuretic, a masking agent, a stimulant, a narcotic, a cannabinoid, a glucocorticosteriod, or a beta-blocker; a growth hormone, insulin¬ like growth factor (IGF-1), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), mechano growth factor (MGF), platelet-derived growth factor (PDGF), vascular-endothelial growth factor (VEGF) when administered into the body well beyond 36 hours post administration.

The measurement of gene expression profiles within peripheral blood mononuclear cells (PBMCs) such as via the quantification of transcriptional products or outside PBMCs such as via the quantification of translational products that are secreted from the PBMCs provides a valid and reliable basis for the detection of the use of recombinant human growth hormone (rhGH), for example, as a banned ergogenic aid.

Gene Expression Profiles

The method of the invention involves profiling of gene expression in one or more genes that are affected by a substance such as exogenous GH (e.g. rhGH) after administration to the body. Without being bound by any one mechanism of action, the one or more genes are either directly or indirectly affected by the presence of the substance such as rhGH. As described herein and shown in the

Examples, the affect can be immediate or anytime up to at least 2 1 days after last administration of rhGH.

Measuring Transcription

The assessment of gene expression profiles can be achieved in many ways. Any known technique or method that allows the measuring of one or more gene expression forms part of the invention and is contemplated herein. In one example, gene expression may be assessed by measuring transcription of the genes via quantification of any transcriptional products that may be transcribed. In a non limiting example, transcription can be quantified by enumerating any RNA transcript that is transcribed from the one or more genes of the present invention. As contemplated herein, RNA transcripts may include, but not limited to, mRNA, microRNA, ribosomal RNA and dsRNA and any other species of RNA transcripts that can be transcribed by cellular transcriptional machinery. In one example, mRNA is extracted from PBMCs collected from plasma of blood taken from a subject who may or may not be taking exogenous GH. The method of the invention has the ability of assessing transcriptional profiles such as the quantification of mRNA transcripts on a genome-wide scale (i.e. ~ 35,000 genes). Transcriptional profiles may be assessed by a rolling circle technique. As contemplated herein, the rolling circle technique may be used to assess gene expression by, for example, isolating a certain nucleic acid sequence of a genome such as the , then circularising the sequence followed by assessment of gene expression by rolling circle amplification.

Rolling circle replication as described herein includes unidirectional nucleic acid replication with rapid synthesis of multiple copies of circular molecules of DNA or RNA. In one example as contemplated herein, a technique involving rolling circle replication may be implemented to determine transcriptional profiles on a genome-wide scale. Rolling circle DNA replication may be initiated by an initiator protein encoded by a plasmid or bacteriophage DNA, which nicks one strand of double-stranded, circular DNA at a site called the double-strand origin, or DSO. The initiator protein remains bound to the 5' phosphate end of the nicked strand, and the free 3' hydroxyl end is released to serve as a primer for DNA synthesis by

DNA polymerase III. Using the unnicked strand as a template, replication proceeds around the circular

DNA molecule, displacing the nicked strand as single-stranded DNA. Displacement of the nicked strand is carried out by a host-encoded helicase called PcrA (the abbreviation standing for plasmid copy reduced) in the presence of the plasmid replication initiation protein. Continued DNA synthesis can produce multiple single-stranded linear copies of the original DNA in a continuous head-to-tail series called a concatemer.

These linear copies can be converted to double-stranded circular molecules through the following process: the initiator protein makes another nick to terminate synthesis of the first (leading) strand; RNA polymerase and DNA polymerase III then replicate the single-stranded origin (SSO) DNA to make another double- stranded circle; DNA polymerase I removes the primer, replacing it with DNA, and DNA ligase joins the ends to make another molecule of double-stranded circular DNA. Rolling circle replication is useful for amplifying DNA from very small amounts of starting material.

Also, the use of microarray technology to determine change in expression levels of one or more genes is contemplated herein and is just one example of a technique that may be used within the bounds of the invention. As described and contemplated herein, microarray technology refers to DNA microarray and comprises the use of an arrayed series of thousands of microscopic spots of DNA oligonucleotides each containing picomolar amounts of (10~12 moles) of a specific DNA sequence, known in the art as probes (or reporters). The DNA sequences as used herein relate to the one or more genes described herein. Relatively short sections of the genes are used to hybridize a cDNA or cRNA sample (known in the art as target) under high-stringency conditions. Probe-target hybridization is usually detected and quantified by detection of fluorophore-, silver-, or chemiluminescence-labeled targets to determine relative abundance of nucleic acid sequences in the target which is contemplated herein.

Standard microarrays are contemplated herein and include attached probes via surface engineering to a solid surface by a covalent bond to a chemical matrix (via epoxy-silane, amino-silane, lysine, polyacrylamide or others). The solid surface can be glass or a silicon chip, in which case they are commonly known as gene chip or colloquially Affy chip when an Affymetrix chip is used. Other microarray platforms, such as lllumina, use microscopic beads, instead of the large solid support are contemplated herein. As described herein, various embodiments of the standard microarrays include DNA microarrays,

MMChips arrays, protein microarray, cellular microarrays, chemical compound arrays, antibody microarrays and carbohydrate arrays.

Within the realm of DNA microarrays, the inventors contemplate cDNA microarrays, oligonucleotide microarrays and SNP microarrays.

The use of a SNP microarray is to detect a single nucleotide polymorphism (SNP). A SNP array is a type of DNA microarray which is used to detect polymorphisms within a population which within the scope of the invention is to detect individuals that have taken an exogenous substance. A SNP is the most frequent type of variation in the genome. For example, there are around 10 million SNPs that have been identified in the human genome

MicroRNA arrays such as MMChips array for example is directed to surveillance of microRNA populations. MicroRNAs (miRNAs) found in populations in the human body are short ribonucleic acid

(R A) molecules, and on average approximately 22 nucleotides long. miRNAs are post-transcriptional regulators that bind to complementary sequences on target messenger RNA transcripts (mRNAs), usually resulting in translational repression and gene silencing. The human genome may encode over 1000 miRNAs which may target about 60% of mammalian genes and are abundant in many human cell types.

As contemplated herein, many of these targeted genes relate to doping and are considered to fall within the scope of the invention.

Measuring Transcription

In one example, gene expression is assessed by measuring translation of RNA transcripts of the genes. In a non limiting example, translational products such as polypeptides or proteins can be assessed in many ways. Any technique or method for quantifying translational products forms part of the invention and is contemplated herein. The technique can include the step of separating plasma from blood collected from one or more subjects. Plasma can be separated by centrifugation. As contemplated herein, the polypeptides or proteins may be in the non-cellular matrix of the plasma as it has been found that some of the genes in the PBMCs that are affected by exogenous GH encode translational products that are secreted out of the PBMCs. Alternatively and additionally, the present invention also contemplates polypeptides and proteins that remain within the PBMCs.

Change in Expression Levels

As contemplated herein, the change in expression levels of the one or more genes that is affected by exogenous administration of a substance such as GH can be detected immediately. It can also be detected from about one week, two weeks, three weeks, four weeks and five weeks from last administration. As exemplified herein, change in gene expression can be detected at time points 8, 15, 22 and 29 days from the last administration of exogenous GH wherein day 0 is the last administration of exogenous GH. The expression levels of one or more genes have been shown to either be up-regulated or down-regulated between day 0 and day 8, 15, 22 or 29; between day 8 and day 15, 22 or 29; between day 15 and day 22 or 29 and between day 22 and day 29.

The transcriptional expression of genes listed in Table 1 and visualised in Figure 1 consistently increased (i.e. up-regulated) over a 29 day period (approximately 4 weeks) wherein day 0 is the last administration of exogenous GH. Reciprocally, the transcriptional expression of genes listed in Table 2 and visualised in Figure 2 consistently decreased (i.e. down-regulated) over a 29 day period

(approximately 4 weeks) wherein day 0 is the last administration of exogenous GH.

To score changes in gene expression, differential gene expression across blood samples collected from subjects that have exogenous GH administered to him or her (test samples) and subjects that have not received exogenous GH (control samples) was calculated and expressed as Z scores. Wk 1Z corresponds to the differences in gene expression between baseline and Day 8; Wk 2Z between Day 15 and baseline, Wk 3Z between Day 22 and baseline and Wk 4Z between Day 29 and baseline. The weekly differential gene expressions between test and control samples were then compared and expressed as

"slope" or M values. The value of M should be proportional to effect of exogenous GH administration on expression of a particular gene. Tables 3 and 4 represent a list of genes that are showing incremental or decremental M values calculated across Day 29, Day 22, Day 15 and Day 8. For example, Table 3 contains M values for gene expression from Day 8 and Day 15. For example, Figures 5 and 6 show 10 genes each, respectively, that display relatively large incremental or decremental changes in gene expression (i.e. large change in Z scores and thus M+ and . M- values) from Day 8 and Day 15 (i.e. between time point 2 (i.e. second week post injection) and time point 1 (i.e. first week post injection). Table

4, for example, contains M values for gene expression from Day 8, Day 15 and Day 22. Figures 7 and 8 show 10 genes each, respectively, that display relatively large incremental or decremental changes in gene expression (i.e. large change in Z scores and thus M+ and M- values) from Day 8, Day 15 and Day

22 (i.e. between time point 3 (i.e. third week post injection), time point 2 and time point 1 (i.e. first week post injection). Figures 3 and 4 show 10 genes each, respectively, that display large incremental differences in expression levels between day 8 (i.e. time point 1 (i.e. first week post injection) and baseline which resulted in large change in Z scores and thus M+ and M- values respectively. Figures 9 and 10 show 10 genes each, respectively, that display relatively large incremental or decremental changes in gene expression (i.e. large change in Z scores and thus M+ and M- values) from Day 8, Day 15, Day 22 and Day 29 (i.e. between time point 4 (i.e. fourth week post injection), time point 3 (i.e. third week post injection), time point 2 and time point 1 (i.e. first week post injection). Antibodies

In a non-limiting example, there is contemplation of use of one or more antibodies directed to the translational products, either free or in association with other molecules, for the detection of translational expression. The translational products may be quantified by antibody binding whereby one or more antibodies have a detectable label. Alternatively, the antibodies may be detected by virtue of binding with a secondary antibody or reagent that is appropriately labeled to enable detection and subsequent quantification of translational products. Determining translational expression levels can be accomplished by any one of a number of techniques known in the art including, but not limited to, an immunoassay such as enzyme-linked immunosorbent assays (ELISA), sandwich immunoassays, competitive immunoassays, immunoradiometric assays (IRMA), radioimmunoassays (RIA), immunoelectrophoresis assays, in situ immunoassays, immunodiffusion assays, immunofluorescence assays, Western blots, ligand-binding assays, biosensors, flow cytometry and the like (see, for example, Ausubel ef a/., eds, 1994, Current

Protocols in Molecular Biology, Vol. 1, John Wiley & Sons, Inc., New York). A variety of methods is known in the art for detecting binding in an immunoassay and is included in the scope of the present invention.

It will be appreciated that the methods described above are merely examples of the types of methods that may be utilised to identify translational products of the RNA transcripts of the one or more genes of the present invention. Other suitable methods will be known by persons skilled in the art and are within the scope of this invention.

The antibodies may be polyclonal or monoclonal and may be raised against a full-length and/or wild- type sequence of one or more translational products or a recombinant, variant, analogue, derivative or fragment thereof of RNA transcripts" transcribed from one or more genes listed in Tables 1 to 4 and as shown in Figures 1 to 10. Suitable antibodies may be prepared from discrete regions or fragments of full- length and/or wild-type sequences of one or more translational products of RNA transcripts transcribed from one or more genes listed in Tables 1 to 4 and as shown in Figures 1 to 10.

Persons skilled in the art will readily understand and appreciate that several methods of generation may be used to produce antibodies, either monoclonal or polyclonal, suitable for performance of the invention. Suitable antibodies include, but are not limited to polyclonal, monoclonal, chimeric, humanised, single chain, Fab fragments, Fv fragments and Fab expression libraries.

An antigenic polypeptide contains at least about 5, and typically at least about 10, amino acids but can be more. Methods for the generation of suitable antibodies will be readily appreciated by those skilled in the art. For example, an anti-GASP-1 monoclonal antibody, typically containing Fab portions, may be prepared using the hybridoma technology described in Antibodies - A Laboratory Manual, Harlow and Lane, eds., Cold Spring Harbour Laboratory, N.Y. (1988). In essence, in relation to the preparation of monoclonal antibodies, any technique that provides for the production of antibody molecules by continuous cell lines in culture may be used. These include the hybridoma technique originally developed by Kohler et al., Nature, 256:495-497 (1975), as well as the trioma technique, the human B-cell hybridoma technique

[Kozbor ef a/., Immunology Today, 4:72 (1983)], and the EBV-hybridoma technique to produce human monoclonal antibodies [Cole ef al., in Monoclonal Antibodies and Cancer Therapy, pp. 77-96, Alan R . Liss,

Inc., (1985)]. Immortal, antibody-producing cell lines can be created by techniques other than fusion, such as direct transformation of B lymphocytes with oncogenic DNA, or transfection with Epstein-Barr virus.

See, e.g., M . Schreier et al., "Hybridoma Techniques" (1980); Hammerling et al., "Monoclonal Antibodies and T-cell Hybridomas" (1981); Kennett ef al., "Monoclonal Antibodies" (1980).

A monoclonal antibody useful in practicing the present invention can be produced by initiating a monoclonal hybridoma culture comprising a nutrient medium containing a hybridoma that secretes antibody molecules of the appropriate antigen specificity. The culture is maintained under conditions and for a time period sufficient for the hybridoma to secrete the antibody molecules into the medium. The antibody-containing medium is then collected. The antibody molecules can then be further isolated by well- known techniques.

Similarly, there are various procedures known in the art which may be used for the production of polyclonal antibodies to full-length and/or wild-type sequence of one or more translational products or a recombinant, variant, analogue, derivative or fragment thereof of RNA transcripts transcribed from one or more genes listed in Tables 1 to 4 and as shown in Figures 1 to 10.

For the production of polyclonal antibodies, various host animals can be immunized by injection with any of the translational products or a recombinant, variant, analogue, derivative or fragment thereof of

RNA transcripts transcribed from one or more genes listed in Tables 1 to 4 and as shown in Figures 1 to

10 including but not limited to rabbits, mice, rats, sheep, goats, etc. with the option of also being conjugated to an immunogenic carrier, e.g., bovine serum albumin (BSA) or keyhole limpet hemocyanin

(KLH). Also, various adjuvants may be used to increase the immunological response, including but not limited to Freund's (complete and incomplete), nitrocellulose, cellulose acetate, mineral gels such as aluminum hydroxide, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanins, dinitrophenol, and potentially useful human adjuvants such as BCG (bacille Calmette-Guerin) and Corynebacterium parvum. Sampling

Biological samples are collected from men and women alike. In one embodiment, blood samples are the biological samples collected from one or more subjects that have or have not engaged in doping events such as the administration of a substance as described herein (e.g. exogenous GH).

Blood is spun to obtain plasma for subsequent determination of gene expression or detection of

SNPs. Gene expression whether that be quantifying RNA transcripts or translational products, blood is collected. The control sample is a blood sample from one or more subjects known not to take exogenous

GH. The control is analysed at the same time the biological sample is analysed. Samples from healthy subjects, known to not take a substance as described herein (e.g. exogenous GH), may be tested in order to establish a normal range or fluctuation of gene expression which the biological samples are compared.

The method of the invention may also be implemented in conjunction with other methods and techniques. For example, insulin and/or anabolic steroids may be tested along with gene expression of one or more genes that are affected by the presence of the substance, such as rhGH.

Methods for detecting administration of exogenous growth hormone

The present invention provides a method for detecting administration of a substance into the body of a subject. Such a substance may be an antagonist or agonist. For example, the substance may be a growth hormone (GH) such as rhGH. The present invention provides a method for detecting administration of a substance to a subject whereby the method comprises obtaining a biological sample from the subject and analyzing the biological sample to determine expression levels of one or more genes whereby change in one or more expression levels of the one or more genes in the biological sample, when compared to a control sample, is indicative of administration of the substance to the subject.

Methods for screening biological samples

The present invention provides a method for screening one or more biological samples from one or more subjects to determine whether a substance was administered to the one or more subjects. The present invention provides a method for screening one or more biological samples from one or more subjects to determine whether a substance was administered to the one or more subjects whereby the method comprises obtaining the one or more biological samples from the one or more subjects analyzing the one or more biological samples to determine expression levels of one or more genes whereby change in expression levels of the one or more genes in the one or more biological samples, when compared to a control sample, is indicative of administration of the substance to the one or more subjects. Translational and/or Transcriptional Products

The present invention provides one or more translational products and/or one or more transcriptional products of the one or more isolated genes of the above-mentioned methods. An example of a translational product is GASP-1 .

Translational and/or Transcriptional Products

The present invention provides use of one or more genes for detecting administration of a substance to a subject whereby the use comprises obtaining a biological sample from the subject and analyzing the biological sample to determine expression levels of the one or more genes whereby change in one or more expression levels of the one or more genes in the biological sample, when compared to a control sample, is indicative of administration of the substance to the subject.

Use of One or More Genes

The present invention provides use of one or more genes for screening one or more biological samples from one or more subjects to determine whether a substance was administered to the one or more subjects. The present invention provides use of one or more genes for screening one or more biological samples from one or more subjects to determine whether a substance was administered to the one or more subjects, whereby the use comprises obtaining the one or more biological samples from the one or more subjects and analyzing the one or more biological samples to determine expression levels of one or more genes whereby change in expression levels of the one or more genes in the one or more biological samples, when compared to a control sample, is indicative of administration of a substance to the one or more subjects.

The present invention also provides use of one or more compounds to determine administration of a substance to a subject whereby the use comprises quantifying the number of transcriptional and/or translational products of one or more genes and measuring ope or more expression levels of the one or more genes with the one or more compounds whereby change in the one or more expression levels of the one or more transcriptional and/or translational products in the biological sample, when compared to a control sample, is indicative of administration of the substance to the subject.

As contemplated herein, one or more of these genes can be found in Tables 1 and 2 and as shown in Figures 1 to 10. An example of such a gene is WFIKKN2. There is also contemplation for the translational product of WFIKKN2 which is GASP-1 .

Kits

The present invention provides a kit when used for detecting administration of a substance to a subject. The present invention provides a kit when used for detecting administration of a substance to a subject whereby the kit comprises means for analysing a biological sample obtained from the subject to determine expression levels of one or more genes whereby change in one or more expression levels of the one or more genes in the biological sample, when compared to a control sample, is indicative of administration of the substance to the subject.

The present invention provides a kit when used for screening one or more biological samples from one or more subjects to determine whether a substance was administered to the one or more subjects, wherein the kit comprises means for analyzing the one or more biological samples to determine expression levels of one or more genes whereby change in expression levels of the one or more genes in the one or more biological samples, when compared to a control sample, is indicative of administration of the substance to the one or more subjects.

Polypeptides

As disclosed herein the present invention contemplates polypeptides for use in detecting translational products. The polypeptides may comprise full-length and/or wild-type sequences of translational products and include modification such as the addition, deletion, or substitution of one or more amino acid residues. Further, amino acid additions may involve the fusion of the polypeptide or fragment thereof with a second polypeptide or peptide, such as a polyhistidine tag, maltose binding protein fusion, glutathione S transferase fusion, green fluorescent protein fusion, or the addition of an epitope tag such as FLAG, c-myc or hexahistidine tag.

The term "variant" as used herein refers to substantially similar sequences. Generally, polypeptide sequence variants possess qualitative biological activity in common. Further, these polypeptide sequence variants may share at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or

99% sequence identity. Also included within the meaning of the term "variant" are homologues of polypeptides of the invention. A homologue is typically a polypeptide from a different species but sharing substantially the same biological function or activity as the corresponding polypeptide disclosed herein.

Further, the term "variant" also includes analogues of the polypeptides encoded by one or more genes of the invention, wherein the term "analogue" means a polypeptide which is a derivative of a polypeptide encoded by one of the genes of the invention, which derivative comprises addition, deletion, substitution of one or more amino acids, such that the polypeptide retains substantially the same function.

The present invention also contemplates fragments of the polypeptides disclosed herein. The term

"fragment" refers to a polypeptide molecule that encodes a constituent or is a constituent of a polypeptide encoded by one or the genes of the invention or variant thereof. Typically the fragment possesses qualitative biological activity in common with the polypeptide of which it is a constituent. The peptide fragment may be between about 5 to about 150 amino acids in length, between about 5 to about 100 amino acids in length, between about 5 to about 50 amino acids in length, or between about 5 to about 25 amino acids in length. Alternatively, the peptide fragment may be between about 5 to about 15 amino acids in length.

Polynucleotides

Embodiments of the present invention provide polynucleotides as described above, and variants and fragments of such polynucleotides. As for polypeptides discussed above, the term "variant" as used herein refers to substantially similar sequences. Generally, polynucleotide sequence variants encode polypeptides which possess qualitative biological activity in common. Further, these polynucleotide sequence variants may share at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%,

97%, 98% or 99% sequence identity to the transcriptional products. Also included within the meaning of the term "variant" are homologues of polynucleotides described herein. A homologue is typically a polynucleotide from a different species but sharing substantially the same activity.

Fragments of polynucleotides of the invention are also contemplated. The term "fragment" refers to a nucleic acid molecule that encodes a constituent or is a constituent of a polynucleotide of the invention.

Fragments of a polynucleotide, do not necessarily need to encode polypeptides which retain biological activity. Rather the fragment may, for example, be useful as a hybridization probe or PCR primer. The fragment may be derived from a polynucleotide or alternatively may be synthesized by some other means, for example chemical synthesis. Polynucleotides and fragments thereof may also be used in the production of antisense molecules using techniques known to those skilled in the art.

Accordingly, the present invention contemplates oligonucleotides and fragments based on the sequences of the polynucleotides as described herein for use as primers and probes. Oligonucleotides are short stretches of nucleotide residues suitable for use in nucleic acid amplification reactions such as

PCR, typically being at least about 10 nucleotides to about 50 nucleotides in length, more typically about

15 to about 30 nucleotides in length. Probes are nucleotide sequences of variable length, for example between about 10 nucleotides and several thousand nucleotides, for use in detection of homologous sequences, typically by hybridization. The level of homology (sequence identity) between sequences will largely be determined by the stringency of hybridization conditions. In particular the nucleotide sequence used as a probe may hybridize to a homologue or other variant of a polynucleotide disclosed herein under conditions of low stringency, medium stringency or high stringency. Low stringency hybridization conditions may correspond to hybridization performed at 50°C in 2 x SSC. There are numerous conditions and factors, well known to those skilled in the art, which may be employed to alter the stringency of hybridization. For instance, the length and nature (DNA, RNA, base composition) of the nucleic acid to be hybridized to a specified nucleic acid; concentration of salts and other components, such as the presence or absence of formamide, dextran sulfate, polyethylene glycol etc; and altering the temperature of the hybridization and/or washing steps. For example, a hybridization filter may be washed twice for 30 minutes in 2 X SSC, 0.5% SDS and at least 55°C (low stringency), at least 60°C (medium stringency), at least 65°C (medium/ high stringency), at least 70°C (high stringency) or at least 75°C (very high stringency).

In particular embodiments, polynucleotides of the invention may be cloned into a vector. The vector may be a plasmid vector, a viral vector, or any other suitable vehicle adapted for the insertion of foreign sequences, their introduction into eukaryotic cells and the expression of the introduced sequences.

Typically the vector is a eukaryotic expression vector and may include expression control and processing sequences such as a promoter, an enhancer, ribosome binding sites, polyadenylation signals and transcription termination sequences.

Screening

Translational or transcriptional products of the invention which bind, or otherwise interact with the polypeptides and polynucleotides described herein may be identified by a variety of suitable methods.

Non limiting methods include the two-hybrid method, co-immunoprecipitation, affinity purification, mass spectroscopy, tandem affinity purification, phage display, label transfer, DNA microarrays/gene coexpression and protein microarrays.

Polypeptides and polynucleotides described herein and appropriate fragments and variants can be used in high-throughput screens to assay for desired translational or transcriptional products. The polypeptides and polynucleotides as described herein and fragments and analogues thereof are useful for the screening and identification of translational or transcriptional products of the invention. Suitable polypeptides and polynucleotides may exert their effect by virtue of either a direct (for example binding) or indirect interaction. Interaction and/or binding between the polypeptides and polynucleotides and translational and transcriptional products of the invention may be determined using standard competitive binding assays, such as gel-shift assays and plate bound assays described within, or two-hybrid assay systems.

Alternatively, affinity chromatography may be used wherein the polypeptide or fragment or variant thereof, may be immobilised on a support (such as sepharose) and cell lysates passed over the column.

Proteins binding to the immobilised polypeptide, fragment or variant can then be eluted from the column and identified. Initially such proteins may be identified by N-terminal amino acid sequencing for example.

In a modification of the above technique, a fusion protein may be generated to bind to a detectable tag, such as alkaline phosphatase, and using a modified form of immunoprecipitation as described by

Flanagan and Leder (1990). Detection may be via a chemical change on a substrate. Suitable labelled substrates include those labelled for colourimetric, radiometric, fluorimetric or fluorescent resonance energy transfer (FRET) based methods, for example.

Other methods that may be employed are co-immunoprecipitation in which the identification of a translational product can be established using a number of methods known in the art, including but not limited to SDS-PAGE, western blotting, and mass spectrometry. Alternatively, the phage display method or affinity chromatography may be used.

The present invention will now be described with reference to specific examples, which should not be construed, in any way, as limiting the scope or spirit of the invention.

Examples

Example 1: Sample Collection, Hybridization and Normalisation

Sample Collection

Subject Selection

Resistance trained males aged 18-38 years of age were recruited for the study that encompasses the Examples described herein. All the males completed a health and physical activity/training questionnaire and were interviewed individually by appropriately qualified and experienced staff at Bond

University. All were free of the symptoms of disease. Any intake of non-prescription drugs (eg: anabolic agents or stimulants) either currently or previously led to exclusion from the study. A final group of 30 males (n=30) was selected as subjects for the project.

Prior to Day 1 of the study, the subjects had their height, weight and 1 x repetition maximum ( 1 RM) bench-press strength measured under controlled conditions. These are termed subject characteristics.

Possible differences between the Experimental and Placebo groups (Table just below) were assessed by the use of Student's T-test. In both cases significance was indicated at p <0.05. Data are expressed as mean (SD). No significant differences were recorded between the Experimental or Placebo groups on any of the parameters listed.

Physical characteristics of subjects (Mean (SD).

Experimental Placebo

(n=15) (n=15)

Mean (SD) Mean (SD) Height (cm) 178.8 (9.5) 178.9 (5.9)

Mass (kg) 81.2 (17.9) 83.1 (9.1)

1 x RM* (kg) 119.4 (28.4) 114.2 (16.8)

Age (yrs) 24.5 (6.5) 26.1 (6.6)

*= Bench press.

All subjects provided written informed consent and all procedures were approved by the Bond

University Human Research Ethics Committee. The subjects were randomly allocated to either

Experimental groups (Injections of 1mg rhGH (Genotropin® "Miniquick", Pfizer, Sydney) each day for 7 days - which is a relatively low dose) or Placebo groups (Control - Sterile physiological saline). All injections were supervised by a qualified Medical Practitioner. No reports of "side-effects" were received during the study.

Blood Sample

Blood samples were obtained by venepuncture of an antecubital vein and placed in appropriate collection tubes - EDTA, for collection of white blood cells and later RNA extraction (as below), and clot- activating tubes for the collection of serum (GH & IGF-1 analyses). Blood samples were collected on days

0 (base-line), 8, 15, 22 & 29. A standardised meal replacement (Body Science, Australia) was provided to each subject to be consumed 60 minutes prior to blood collection. Each 40g serve contained 142 calories,

23 grams of protein, 11 g of carbohydrates and 0.5 g fat.

Mononuclear Cell Extraction

As mentioned previously, EDTA blood collection tubes from each individual were obtained.

Peripheral blood mononuclear cell (PBMC) extraction was carried out on Ficoll-Hypaque by standard methods. Briefly, the protocol consisted of the following: within a 14 mL Falcon tube, 4 mL Gibco PBS, pH7.4 sterile was added to 4 mL of fresh blood. Tubes were inverted 3 times and 8 mL of diluted blood was layered over 4 mL of Ficoll-Hypaque. Post-centrifugation at 900 rcf for 20 minutes/room temperature,

Plasma was removed gently (stored at -80°C) and PBMCs were collected using with a p1000 pipette (filter tipped) and centrifuged at 4°C/4000 RCF/10min and rinsed in PBS, pH7.4 and finally stored at -80°C for further processing. RNA extraction of total RNA

TRizol Plus RNA purification kit (Cat No. 12183-555) was used for RNA collection. Briefly, PBMC tubes were removed from a -80°C freezer and placed at room temperature with Trizol. Lysis of cells was performed several times by passages through a sterile pipette tip and let incubated for 5 min at room temperature. 0.2 ml chroroform was then added and mixed by hand for 15 sec. Following 3 minutes incubation (room temperature), samples were centrifuged at 12,000 x g for 15 minutes at 4°C. A colour¬ less upper phase containing the RNA was collected gently and transferred into a new tube containing an equal volume of 70% ethanol. Sample was vortexed thoroughly for 30 sec and placed above an RNA Spin cartridge (from kit). Binding of RNA, washing steps and elution series were undertaken following manufacturer's instructions. RNA was eluted into 100 uL of pure water and quality control procedures were performed on RNA samples.

Quality Controls

RNA samples were used for RNA integrity analysis and concentration quantitation. Microfluidic

Agilent technology, 2100 Bioanalyzer was used for such quality control. RNA Integrity Numbers (RINs; see

'Quality Controls' section under Example 2) were attributed and any RIN > 7 was considered suitable for microarray processing (Schroeder e a/., 2006).

The microarray was used for the measurement of genome-wide transcriptional profiles (35,000 genes).

Hybridisation & Scanning

Hybridization technique was carried out by the Institute for Molecular Bioscience (1MB, The

University of Queensland, St Lucia, Brisbane, Australia). Beadchip version V3 from lllumina technology was used. Arrays used were lllumina Human Ref-6 Bead-Array (6 pairs of strip) with each pair having

24000 RefSeq genes and 24000 supplemented genes.

Bioinformatic Analysis

The Bioconductor software suite for bioinformatics (http://www.bioconductor.org/) was used to analyze the data with methods sourced from the Limma package. Bioconductor is an open-source and open-development software project for the analysis and comprehension of genomic data. It utilizes the R software package (http://www.r-project.org/) which is a language and environment for statistical computing and graphics.

Normalisation

Pre-processing of lllumina Data - "Normalisation" After reading the data with the Limma software, exploratory data analysis was undertaken.

Commonly, a box-plot displaying the distribution of intensities for each array was generated to investigate any differences in spread across the arrays.

There are various non-biological sources of error involved with lllumina microarray procedures when dealing with different quantities of sample, extracting RNA, washing and hybridizing these samples onto arrays, so methods have been developed to correct for these. Background correction addresses issues such as "background" noise and processing effects as well as adjusting expression estimates so they are placed on a comparable scale. "Normalization" reduces the amount of variability in the data that is due to non-biological sources, so reducing variability of non-differentially expressed genes and this is achieved using a quantile normalization procedure (Quackenbush, 2002). Therefore the resulting normalized data- set has a much more consistent distribution of intensities with less variability from non-biological sources.

Example 2: Gene expression by Microarray

The aim of this analysis was to determine from the expression data a set of genes that is differentially expressed in individuals in response to administration of 1mg of Growth hormone (GH) drug.

The study population involved 20 males aged between 18 and 35 years. They were administered 1mg of

GH daily for a week with samples taken at before injection (baseline), one day post injection day 8 and weekly (day 15, day 22, and day 29). Half of the individuals studied have received a placebo injection series while the other half of the cohort received injections of GH. Arryas used were Human Ref-

6BeadArray (6 pairs of strip) with each pair having 24000 RefSeq genes and 24000 supplemented genes.

The Bioconductor software suite for bioinformatics (http://www.bioconductor.org/) was used to analyze the data with methods sourced from the Limma package. Bioconductor is an open-source and open-development software project for the analysis and comprehension of genomic data. It utilizes the R software package (http://www.r-project.org/) which is a language and environment for statistical computing and graphics.

These data consist of six arrays that were used in the analysis. Four arrays were undertaken from the same individual corresponding to baseline, day 8, day 15 and day 22. Two additional arrays were undertaken on a second individual for baseline and day 8.

Preprocessing ofillumina Data

Preprocessing was carried as described under Example 1. The normalization process is as follows:

(i) data is log 2 transformed given the inherent exponential nature of all hybridization results; (ii) a normalization factor N is calculated using the relatives sums technique for each hybridization pair (control/intervention); (ii) then little z scores are calculated based on a 95% confidence interval. The resulting normalized dataset has a much more consistent distribution of intensities with less variability from non-biological sources and iv) The Capital Z scores in the Tables and/or Figures represent the differences in little z score of each time point for gene expression against baseline. Each of the Z scores has been normalised against the baseline, where this normalisation represented by the Capital Z score.

Differential Expression of Genes following GH Treatment

The ultimate goal of the analysis is to identify the genes differentially expressed between baseline and post drug administration measured 1 day post injections and then weekly. By taking samples from patients that were given placebo, placebo effect can be corrected and lead to further better specific data associated with GH dys-regulation of gene expression.

Material and Methods - Materials (Blood collection & white blood cell extraction)

EDTA blood collection tubes from each individual have been obtained. White blood cell (WBC) extraction was carried out in Ficoll Hypaque. Protocol consisted of the following: within a 14 ml falcon tube,

4 ml GIbco PBS, PH7.4 sterile is added to 4 ml of fresh blood; Tubes were inverted 3 times and 8ml of diluted blood is layered over 4ml of Ficoll-paque containing tube (Gently with Pasteur pipette). Post

Centrifugation at 900 rcf for 20 minutes/Room temperature, Plasma was removed gently (stored at -80C) and WBC were collected using with a p1000 pipette (filter tipped) and spined down at 4C/4000 RCF/10min and rinsed in PBS, PH7.4 and finally stored at-80C for further processing.

RNA extraction and quality controls- Extraction of total RNA

TRizol Plus RNA purification kit (Cat No. 12183-555) was used for RNA collection. Briefly, WBC tubes were removed from -80°C freezer and placed at room temperature with Trizol. Lysis of cells was performed by several times passages through a sterile pipette tip and let incubated for 5 min at room temperature. 0.2 ml of chloroform was then added to the mixed shook by hand for 15 sec. Following 3 minutes incubation (room temperature), sample was centrifuged at 12,000 x g for 15 minutes at 4 degrees

Celsius. A colourless upper phase containing the RNA was collected gently and transferred into a new tube containing an equal volume of 70% ethanol. Sample was vortex thoroughly for 30 sec and placed above a RNA Spin cartridge (from kit). Binding of RNA, washing steps and elution series were undertaken following manufacturer's instructions. RNA was eluted into 100 ul of pure water and quality control established on RNA samples.

Quality controls

RNA samples were used for RNA integrity analysis and concentration quantification. Microfluidic

Agilent technology, 2100 Bioanalyzer was used for such quality control. RIN numbers were attributed and any > to RIN of 7 are suited for microarray processing. Total RNA control for each sample were denoted 'Pass'. All cRNA quality control for each sample were denoted 'Pass' and the whole quality control for each sample processed are denoted 'Pass'. If Pass was not denoted, samples would not be processed and will not contribute to data processing. All samples have passed all quality controls.

RNA with RIN of 8.5; Individual 10, day 8.

Hybridization technique was carried out by the 1MB centre (Institute for Molecular Bioscience, The

University of Queensland, St Lucia, Brisbane, Australia). Beadchip version V3 form illumina technology was used.

Result - Data analysis: Raw data were normalised and differential expressions calculated.

Differential gene expression across the different blood samples were calculated and expressed as Z scores. Z 1 correspond to the gene expression difference of both gene expression profiles between day 0

(baseline) and day 8; Z2 between day 0 and day 15; Z3 between day 0 and day 22; and Z4 between day 0 and 29. Figures 1 and 2 below show gene expression at Z 1 and how these genes are progressing in expression in Z2, Z3 and Z4 situations.

Further data analysis was performed as follows:

i) Differentially expressed genes found as Z 1 scores [reflecting difference of gene expression between baseline (pre GH injection) and day 8 (first day post daily injection series of GH)] were listed. Z2,

Z3 and Z4 scores were also generated and genes subsequently listed. A list of differentially expressed genes, either positively or negatively expressed is listed in Tables 1 to 4. Figures 1 and 2 represent 24 of the most down and up-regulated genes expressed between baseline (pre GH injection) and subsequent post daily injection series of GH.

ii) All Z scores for each gene can be further processed and put through a linear regression analysis.

Slope values corresponding to each gene obtained from the linear regression plotting was calculated to generate a M value. Each individual gene can be monitored through its Z scores along time post injection of Growth hormone. M values can either be positive to negative values with the aim to reflect or denote a trend of gene expression specifically attributed to GH injection. 'Trend' expression represents a powerful assessment for individual gene 'behaviour' and enable the cluster of set of genes GH induced genes and identification of pathway involved in such induction.

One of the up-regulated genes, WFIKKN2, codes for a protein, "growth and differentiation factor-1"

(GASP-1) that is secreted and may be the basis of a proteomic, rather than a genomic, method for the detection of rhGH. Then inventors will now measure GASP-1 by ELISA and predict that there will be a constant increase in GASP-1 expression over, at least, a 2 1 day period from the last administration of exogenous GH.

Serum GH and IGF-i Concentrations

Serum concentrations of IGF-1 were analysed by use of an IGF-1 specific RIA (Bioclone, Australia).

Serum GH concentrations were assayed by use of a solid-phase, two site chemiluminescent immunometric assay (Immulite 2000, Siemens, Sydney). A repeated measures ANOVA with Bonferroni correction was applied to the analysis of GH and IGF-1 data and presented in the below table. Serum growth hormone and IGF-1 concentrations were measured on Days 0, 8, 15, 22 & 29.

* : p < 0.001 compared to the Placebo group

# : p<0.05 compared to Day 0 . There were no significant differences in serum growth hormone concentrations either between the

Experimental and Placebo groups at any sampling point or within either group across time (Day 0 - Day

29). The Experimental and Placebo groups only differed significantly from each other with respect to serum IGF-1 concentrations when assessed on Day 8 ie: Immediately after the seven day's of rhGH administration, where IGF-1 concentrations were significantly elevated by 56% in the Experimental group

(p <0.001). At no other time did the Exp and Placebo groups differ in relation to serum IGF-1 concentrations. Serum IGF-1 concentration in the Experimental group was increased significantly (p<0.05) only on Day 8 with respect to the Day 0 concentration. There were no significant differences in serum IGF-

1 concentrations within the Placebo group when assessed in relation to the Day 0 concentration.

Example 3 : Gene expression by Real time PCR

cDNA generated from DNA collected from control samples and from samples taken from subjects having exogenous GH administered to him or her (i.e. test samples) were used as template for real time

PCR experiments. The technique was used to calculate precisely the fold difference regulation of a single gene between two different types of cDNA, that being cDNA from control samples and cDNA from samples taken from subjects accepting exogenous GH administration.

Real time PCR was undertaken on a gene selected randomly from the transcriptome ((i.e. interleukin 6 receptor; IL-6R) in order to calculate the gene expression fold regulation difference between control (CTL samples) and Experimental samples (i.e. with recombinant human GH (rhGH)). Real time

PCR fold difference assessments were undertaken for each point of the experiment: baseline, day 8, day

15, day 22 and day 29.

Specifically, real time PCR was undertaken as follows: Ribosomal RNA (18s) was used as an internal control and IL-6R were screened for each cDNA at the following PCR cycles using Biorad master mix containing Sybr green. PCR cycles consisted of 94°C for 12 minutes, followed by the repetition of 45 cycles of 94°C for 30sec, 59°C for 30sec and 72°C for 30 sec. Melting temperatures was set at a ramping from 50°C to 99°C with 1°C ramping every 5 seconds. Delta Ct was calculated providing fold regulations and compared to microarray data.

Primers for the internal control ribosomal RNA gene18s and the gene interleukin-6 receptor were designed as follow sequences:

o 18s: forward primer as CTTAGAGGGACAAGTGGCG and reverse primer as

GGACGTCTAAAGGGCATCACA o II6R: forward primer as GACCCCCACTCCTGGAACTC and reverse primer as

TTGACCATCCATGTTGTGAATGT

Gene sequences were obtained from Ensembl (http://www.ensembl.org/) . PCR were performed using a Biorad cocktail of Sybr Green mix and Taq DNA polymerase as well and added to the forward and reverse primers in presence of free dNTPs, dTT and cDNA in a final volume of 25 µ Ι.

The following work for cDNA synthesis was undertaken:

o In a 200 L tube, the following was added: 1 ul of random primers; 1 ul of dNTPs mix, 11ul of

Pool RNA (Pool of all control RNA at each time point or Pool of all sample RNA at each time point)

o The above mix was gently mixed (by up and down pipetting)

o Left at 65C/5minutes And

o 7ul of the following bulk was added (bulk containing: 5XFS buffer 4ul; 0.1 M dTT 1ul; Rnase out 1ul and Superscript III 1ul) and then mixed GENTLY (up and down pipetting),

o Left at 25°C for 5 minutes

o Put this at 50°C for 1 hour

o Put this at 70°C for 5 minutes

o Store at -20°C

For real-time PCR, cDNA used was thawed and diluted 25X into Dnase/RNase free pure water.

Detection of PCR product in real time was performed using the Corbett Research Rotor-Gene 3000.

PCR volumes were placed in individual Corbett 0.1 ml strip tubes on -20°C pre-cool metal tube carriers with this order: cDNA, PCR mix. Tubes were closed off and manually handle to allow the whole PCR solution to be at the bottom of the tube. All PCR tubes were placed in the 72 well Rotor within the real time

PCR machine. The following cycling conditions were used and entered in the Rotor Gene software

(Version: Cycle 1, 94°C 4 min (x1), Cycle 2, 94°C 30sec, 59°C 30sec, 72°C 30sec (x45). A post-PCR amplification protocol was preset before the run to obtain melt curve representations (ramping from 50 to

99°C with 1°C ramping every 5 seconds).

Data Analysis

Following Q-PCR analysis, CT values from triplicates were collected at linearity and used to calculate the 18S rRNA corrected CT (or ACT) for each gene. Triplicate repeat ACT were assigned with ±

SE determinations and were then used to calculate the mean corrected difference in CT between controls and samples (or CT ± SE). The extent of the response is determined by 2 mean ( CT), while a negative value suggests repression of gene expression, so the relative degree of response is calculated by

2 -mean (MCT, denoted in the below table as DDCt)). Folds Baseline Tpl tp2 Tp3 Tp4 Realtime (2e(-DDCt)) 53 1.05 1. 0 0.86 1.03 Microarray (z score) 0.97 0.93 0.99 . 0.97 Sdev 0.31 0.09 0.22 0.10 0.05

The table above shows lnterleukin-6 Receptor gene fold expression differences in the data between control and Experimental (control) samples as found in data generated by in the microarray technique as compared to real time PCR. The complete date set involves 78 arrays, 73 representing 5 subjects from the Experimental group, analysed at each of five (5) sampling points (less two samples that did not pass the quality control procedures) and a further five (5) representing "pooled" samples collected from the subjects in the Placebo group at each of the five sampling points (Days 0, 8,15, 22, 29). There was a high degree of concordance between the results from the microarray and RT-PCR methodologies.

Example 4 : Summary of Results and Discussion on Logistic Regression/Algorithms

The data described herein indicates that changes in gene expression of select genes are indicative of exogenous GH administration. This study as represented by the Examples herein provides the basis for the development of a new blood test for the detection of rhGH based on the application of transcriptional profiling and/or RT-PCR to gene expression within peripheral blood mononuclear cells (PBMCs).

This study has identified different sets of genes within PBMCs whose transcriptional expression is consistently, and very importantly increasingly up-regulated (Table 1) and increasingly down-regulated

(Table 2) by rhGH across the post-administration period (ie: Days 8, 15, 22 & 29). The method of the invention has a detection "window" of at least 22 days, which is in contrast to the current, WADA-approved test (the isoform or differential immunoassay method) that has a detection "window" of less than 36 hours

(Holt & Sonksen, 2008). The current WADA-approved test is also considered unlikely to be able to detect use of rhGH in the usual post-competition period and in effect only has application in out of competition, unannounced testing (Holt & Sonksen, 2008). It is predicted that the ability of this methodology to detect the use of rhGH will extend well beyond the 22 day period identified in this study. In that case, the new methodology would prove useful in both "in" and "out" of competition testing, and would be likely to significantly improve the frequency with which those using rhGH are identified.

The analysis of trends in the transcriptional data, as provided by the calculation of "M" values

(Tables 1 & 2), has identified sets of genes that are consistently either "up" or "down" regulated in response to rGH. These genes are prime candidates as "markers" of rhGH that form the basis of a new anti-doping detection method as described herein. As contemplated herein, the anti-doping method of the invention includes the application of statistical techniques such as "logistic regression", techniques that assist in identifying genes most useful in this regard, and provide an algorithm that will identify those subjects who have used a banned substance such as rhGH. It must be noted that in addition to the genes identified in this study (Tables 1 &

2), a full (genome-wide) set of transcription data is available for each subject at each sampling point. The application of logistic regression to the complete data set assists in identifying additional genes of use in the detection of rhGH.

As contemplated herein, models are designed to detect current rhGH use (ON models). The models were analyzed by logistic regression (via application of logit for example which can be performed using GLIM 4 software (Royal Statistical Society, London, UK)) and the coefficients applied to the raw data of all subjects to determine whether those from the Experimental and placebo groups could be correctly identified at the end of rhGH administration. Because of the possible consequences of false positive results in sporting situations, the inventors are contemplating the classification of subjects as rhGH users only if the probability indicated by logit was >0.999999. Models including each of the independent variables singly and in all possible combinations would be analysed. The logit coefficients for every model will be subsequently applied at each of the sampling points to evaluate model sensitivity (correct identification of rhGH users) and specificity (correct identification of non-use).

As contemplated herein, the inventors are developing a process to test models for application during the wash-out period to detect those subjects who had recently used, but were no longer receiving, rhGH

(OFF models). Data from the middle of wash-out (post days 12 and 14 for example) could be used to determine the logit coefficients for all possible models, which were then assessed at each of the sampling points and tested on the athlete reference group as set up at the time of testing.

The validity of the transcriptional profiling technique used in this study was verified by the use of reverse transcription - polymerase chain reaction (RT-PCR) in relation to a randomly selected candidate gene, the interleukin-6 receptor (IL-6R). The expression levels are consistent between the two methodologies, hence validating the use of arrays for the assessment of the expression of individual genes.

Another very important consideration in the interpretation of these results concerns the reliability of this "profiling" methodology in its application to potential "target" populations. In this case, within a subject population of trained males aged 18-38 years of age. Experimental subjects (+rhGH, n = 15) showed consistent changes in transcriptional profiles across the sampling points. The use of the methodology of the present invention is contemplated for other populations (eg: Males in older age categories, females, subjects of different racial origins etc). It should be noted that the dose of rhGH employed in this study (1mg/d x 7 d), which was designed to limit the incidence of possible side-effects, was selected on the basis of being conservative in terms of both dosages used in previous studies (Lange et al., 2002; Taaffe et a/., 1994) and anecdotal reports of use in recreational athletes.

The plasma GH and IGF-1 concentrations determined in this study clearly reflect the difficulty of attempting to develop detection methods for rhGH based on the simple measurement of plasma concentrations of these proteins. Plasma GH concentrations did not differ significantly from Day 0 values at any sampling point, and plasma IGF-1 concentrations were only elevated significantly with respect to

Day 0 values on Day 8 (ie: After 7 daily rhGH injections). Such limited responses necessarily lead to consideration of alternative approaches to the identification of plasmatic factors responsive to rhGH. The potential extensions to this study include the investigation of whether the genes identified thus far as being responsive to rhGH (Tables 4 & 5), produce, or are likely to produce, a protein found in human plasma.

In this regard, the inventors have investigated the gene WFIKKN2 (Table 1), that codes for the protein, GASP-1 (growth and differentiation factor-associated serum protein-1). GASP-1 has a strong affinity for growth and differentiation factor 8 (ie: Myostatin) and inhibits its biological activity (Hill et al.,

2003). Whilst mechanistic considerations are not central to this research and should in no way be a limitation to the scope of the present invention, it is of note that rhGH appears to induce at least some of its physiological effects via inhibition of myostatin, a protein which usually acts to limit the anabolic effects of endogenous growth hormone (Hill et al., 2003).

Given that the expression of WFIKKN2 was increasingly up-regulated after rhGH administration Day

8 < Day 15 < Day 22 < Day 29, it is likely that plasma concentrations of GASP-1 are similarly elevated during this period. More broadly, the identification of proteins or polypeptides whose plasma concentration varies reliably as a consequence of rhGH administration as described herein will allow the development of detection procedures with greater utility world-wide given, the inherently greater stability of protein over

RNA.

The person skilled in the art would by routine method calibrate the transcriptional and/or plasmatic methodologies of the present invention as it relates to sensitivity. The inventors contemplate that these methods may display sufficient sensitivity to detect a single dose of an administered substance such as rhGH, whether that dose be 1mg or other amount. Titration of the sensitivity of these methodologies against a range of dosage (amount x time) regimes will allow the performance limits of the assay to be established and maximise the opportunity to establish a robust, highly sensitive assays for rhGH.

The RNA extraction and processing methods used in this study have proven to result in the isolation of high-quality RNA in amounts sufficient to allow genome-wide analysis of transcriptional regulation. It is important to note that the methodologies employed in this study in relation to the detection of rhGH are applicable for any substance that is administered to the body and has an affect on one or more endogenous genes.

To summarise, this study clearly establishes the utility of transcriptional profiling in the detection of exogenous substances in the body, for example rhGH, a finding that has direct application for the anti- doping detection method as described and defined herein.

The reference to any prior art in this specification is not, and should not be taken as an acknowledgement or any form of suggestion that the referenced prior art forms part of the common general knowledge in Australia.

Example 5 : Tables 1 to 4

TABLE 1: Up-regulated genes (n=68)

TargetID Wk 1Z Wk 2Z Wk 3Z Wk 4Z M +

HS.1 23362 0.66 1.06 3.82 4.14 1.3

HS.148699 0.52 0.80 1.56 4.72 1.3

LOC728763 0.44 0.58 1.14 6.78 2.0

OR10K2 0.37 1.06 3.57 4.71 1.6

LRRC10 0.33 0.92 1.90 5.03 1.5

WFIKKN2 0.29 1.39 2.88 4.31 1.4

LOC652139 0.27 0.82 3.29 3.53 1.2

HS.543090 0.18 0.65 1.20 6.48 1.9

HS.439050 0.12 0.33 0.35 4.39 1.3

LOC284428 0.09 0.45 2.48 3.95 1.4

ARHGAP29 0.07 0.18 0.49 4.79 1.4

GPR1 1 0.07 . 1.1 1 2.19 3.89 1.3

HS.544930 0.00 0.25 1.09 5.00 1.6

LOC647582 -0.04 0.34 3.99 4.17 1.6

HS.566552 -0.12 -0.10 0.35 4.41 1.4

OR52B2 -0.15 0.60 0.61 3.90 1.2

LOC653225 -0.16 0.1 1 0.29 5.66 1.8

FBX017 -0.24 0.18 0.22 5.28 1.7 HS.121775 -0.26 0.27 1.28 3.74 1.3

LOC646484 -0.43 0.10 2.84 3.76 1.5

SPEM1 -0.45 0.57 0.66 3.89 1.3

HS.1 63781 -0.45 0.52 2.63 3.05 1.3

MGC39606 -0.49 0.29 1.99 3.90 1.5

HS.147255 -0.50 -0.39 0.02 3.45 1.2

CDC42BPG -0.52 1.23 1.35 4.35 1.5

LRIT2 -0.56 -0.37 1.20 3.63 1.4

FMR1NB -0.57 0.24 .0.70 3.60 1.3

HS.545435 -0.59 -0.41 0.39 3.96 1.4

INSL6 -0.60 0.63 1.68 3.58 1.4

GLRA2 -0.63 2.06 2.18 3.84 1.4

0R13J1 -0.70 0.39 0.55 3.66 1.3

HS.568640 -0.73 -0.35 0.24 3.34 1.3

LOC653412 -0.77 0.74 2.90 3.95 1.6

HS.538738 -0.81 -0.02 1.49 3.07 1.3

SLC36A2 -0.82 -0.43 0.14 3.12 1.2

HSD17B2 -1.02 -0.12 1.33 2.92 1.3

S100A7 -1.07 0.79 2.28 2.80 1.3

OR51B6 - 1 .10 1.22 2.52 4.41 1.8

HS.560015 - 1 . 1 1 -0.18 1.17 3.29 1.5

HS.543248 -1.43 -1.21 -1.15 2.97 1.3

C40RF28 - 1 .45 -0.14 0.72 2.38 1.2

LOC644431 -1.49 0.02 0.72 3.28 1.5

CHRND -1.66 -1.20 -0.53 4.96 2.1

CYP2W1 -1.69 -0.60 0.55 2.81 1.5

HS.563770 -1.73 -0.98 0.62 2.28 1.4

HS.543479 -1.89 - 1 .62 -0.60 2.41 1.4

LRP4 -2.02 -1.60 0.58 1.78 1.4

HS.570624 -2.03 0.27 1.81 3.67 1.9

HS.570433 -2.07 -1.67 3.09 3.37 2.1

LOC650568 -2.13 -1.46 -1.08 3.33 1.7

HS.544526 -2.15 -1.27 0.89 1.27 1.2 CHRNB2 -2.16 -2.09 1.58 1.98 1.6

HS.541735 -2.16 -1.99 -1.13 1.75 1.3

HS.469608 -2.18 -1.53 0.07 2.86 1.7

HS.1 19816 -2.27 -0.46 1.42 2.80 1.7

HS.575834 -2.54 -1.17 -0.08 1.33 1.3

ATP4A -2.56 -2.25 0.64 2.14 1.7

PCDHB12 -2.67 -2.55 -1.47 1.77 1.4

0R1I1 -2.69 -1.28 1.12 1.91 1.6

HS.554090 -2.81 -2.77 -2.06 2.03 1.5

HS.97443 -2.94 -1.81 0.26 0.98 1.4

HS.277205 -2.99 -1.25 -0.63 1.07 1.3

HS.539654 -3.46 -3.29 -3.00 0.54 1.2

HS. 156470 -3.76 -3.19 -2.82 0.22 1.2

KCNQ5 -4.34 -2.67 -1.88 -0.21 1.3

MGC16291 -5.10 -3.09 -2.29 -0.90 1.3

LOC651655 -5.43 -4.01 -2.10 -1.34 1.4

ZNF678 , -5.82 - 1 .85 -1.23 0.59 2.0

MT1M -6.88 -5.90 -5.74 -2.55 1.3 TABLE 2: Down-regulated genes (n=49)

TargetID Wk1Z Wk2Z Wk3Z Wk4Z

HS. 154607 -1.47 -1.59 -5.15 -5.38 -1.5

LOC645811 0.30 -3.05 -3.58 -4.27 -1.4

NFATC2 0.44 -1.42 -1.74 -4.1 1 -1.4

HS.559868 0.70 -0.05 -2.38 -3.06 -1.4

HS.566874 0.78 -0.87 - 1 .40 -4.56 -1.7

HS.568234 0.91 -2.18 -3.00 -3.13 -1.3

LOC645004 0.94 -1.95 -2.59 -3.64 -1.4

HS.551381 1.33 -4.27 -5.13 -5.88 -2.2

TCEAL6 1.50 -0.05 -1.46 -2.59 -1.4

RUNDC3A 1.59 -0.95 -1.04 -2.67 -1.3

HS.567081 1.79 0.33 - 1 .81 - 1 .88 -1.3

DEFB103A 2.07 - 1.43 - 1 .91 -2.08 -1.3

SLC2A7 2.12 -3.03 -3.76 -3.82 - 1 .9

HS.584074 2.34 0.14 - 1 .30 -2.61 -1.6

HS. 195726 2.40 -1.52 -1.88 -1.93 -1.3

FLJ35848 2.51 -0.75 -1.64 -1.68 -1.3

HMX3 2.84 -0.98 -1.52 -2.05 -1.5

HS.563829 2.94 1.63 0.80 -1.25 -1.3

HS.575043 2.97 2.76 -0.24 -0.62 -1.4

LOC642660 3.09 2.10 -0.10 -0.78 -1.4

LOC642425 3.44 2.89 2.80 -1.17 -1.4

HS.559957 3.46 0.34 0.33 -0.88 -1.3

HS.44210 3.51 -1.40 -2.57 -4.02 -2.4

HS.5381 12 3.52 -0.01 -0.66 -1.40 -1.5

LOC439985 3.64 -1.43 -3.03 -3.27 -2.2

FAM154B 3.68 2.1 1 0.31 -0.48 -1.4

HS.5531 19 3.70 1.34 0.81 -0.40 -1.3

SLC38A4 3.97 1.12 -0.98 -1.03 -1.7

HS.551291 4.05 1.83 0.22 -0.19 -1.4

HS.147007 4.07 2.60 1.45 -0.65 -1.5 LOC647869 4.32 -0.81 -0.91 -1.21 -1.7

LOC440570 4.32 2.52 -0.01 -0.47 -1.7

HS.51 1485 4.35 -0.17 -1.96 -2.45 -2.2

HS.543820 4.38 0.68 0.31 -0.01 -1.4

KRTHA5 4.50 -0.31 -0.42 -0.63 -1.6

HS.582854 4.55 2.03 -0.35 -1.1 1 -1.9

HS.580142 4.58 0.44 -0.47 -0.52 -1.6

HS. 120542 4.81 1.79 0.88 0.73 -1.3

LOC652437 4.82 1.55 -0.22 -0.83 -1.9

HS.562048 4.95 0.58 -1.28 -1.74 -2.2

SST 4.96 3.68 0.70 0.65 -1.6

HS.540137 4.98 1.11 0.39 - 1 .91 -2.1

LOC645953 5.41 -0.74 -1.17 -2.01 -2.3

HS.552808 5.42 2.87 0.31 -0.48 -2.0

HS.580377 5.51 0.96 -0.71 -0.85 -2.1

LOH3CR2A 5.73 1.18 0.73 -0.02 -1.8

CRTAC1 5.89 0.84 0.60 -0.90 -2.1

HS.564724 6.03 4.75 1.57 -0.74 -2.4

HS.576427 7.46 2.87 1.90 0.98 -2.0

LOC642140 7.60 0.79 0.36 -0.08 -2.3 Table 3 TargetID z w k 1 ;z w k 2 z w k 3 z w k 4 w k 5 w k 1 w k 2 w k 3 w k 4 w k 5 abs(m) GCGR -1.39 -1.48 8.08 -0.24 1.07 1 2 3 4 5 9.55 9.55 H1F00 3.66 -1.31 7.63 -0.32 -0.29 1 2 3 4 5 8.93 8.93 LOC651961 0.24 -1.33 7.55 0.01 -0.87 1 2 3 4 5 8.88 8.88 OR1L3 -0.97 -1.06 7.48 -0.57 -0.52 1 2 3 4 5 8.54 8.54 HS.130079 -0.21 -0.23 8.23 1.28 3.45 1 2 3 4 5 8.46 8.46 TMEM190 -1.34 -0.77 7.63 0.12 0.94 1 2 3 4 5 8.40 8.40 HS.580461 -0.80 -0.43 7.91 -0.49 0.54 1 2 3 4 5 8.34 8.34 LOC650239 1.59! -1.76 6.57 -0.25 0.33 1 2 3 4 5 8.32 8.32 HTR1B -1.16, -1.43 6.72 -2.09 0.57 1 2 3 4 5 8.15 8.15 LOC647849 0.53 -0.59 7.43 0.40 0.53 1 2 3 4 5 8.02 8.02 HS.583929 -0.18 -0.39 7.57 -1.36 -0.67 1 2 3 4 5 7.96 7.96 HS.583205 0.62 -2.03 5.89 0.37 -0.46 1 2 3 4 5 7.92 7.92 HS.537523 -0.62 -1.90 6.01 -0.83 0.48 1 2 3 4 5 7.91 7.91 FAM71A -0.40 -1.19 6.58 0.58 1.10 1 2 3 4 5 7.78 7.78 HS.253235 -0.85 0.80 8.50 -1.00 -0.06 1 2 3 4 5 7.70 7.70 HS.278289 1.16 -0.08 7.59 7.50 0.70 1 2 3 4 5 7.67 7.67 LOC649757 1.81 -0.45 7.10 -0.94 1.41 1 2 3 4 5 7.55 7.55 MEGF11 -0.87 -2.33 5.20 -0.90 1.27 1 2 3 4 5 7.53 7.53 HS.364519 5.33 -0.11 7.40 -1.42 1.07 1 2 3 4 5 7.52 7.52 HS.134871 5.34 0.08 7.54 0.64 1.36 1 2 3 4 5 7.46 7.46 LOC440687 1.66 0.48 7.91 0.66 3.02 1 2 3 4 5 7.43 7.43 GRK7 -1.39 -0.18 7.24 -1.11 2.31 1 2 3 4 5 7.42 7.42 LOC645686 1.14 -0.42 6.93 0.32 -0.03 1 2 3 4 5 7.35 7.35 FU20184 -0.80 -0.24 6.98 1.35 -0.64 1 2 3 4 5 7.21 7.21 HS.579965 3.50 0.44 7.65 -0.62 0.08 1 2 3 4 5 7.21 7.21 LOC643799 -0.58 -0.53 6.68 0.05 -0.30 1 2 3 4 5 7.20 7.20 OR5H6 -1.45 0.23 7.41 1.00 -0.86 1 2 3 4 5 7.18 7.18 HS.577834 -2.05 -2.87 4.28 1.76 -0.08 1 2 3 4 5 7.16 7.16 HS.171022 -0.35 0.74 7.86 1.83 0.12 1 2 3 4 5 7.12 7.12 IFNA6 1.31 -0.05 6.86 -1.04 -0.88 1 2 3 4 5 6.91 6.91 OR6K2 0.45 -1.00 5.74 0.23 0.67 1 2 3 4 5 6.74 6.74 LOC649891 1.36 -0.90 5.77 3.89 1.23 1 2 3 4 5 6.68 6.68 HS.23725 -0.43 -0.26 6.41 0.06 4.14 1 2 3 4 5 6.67 6.67 IL2 -0.59 0.44 7.11 0.28 0.14 1 2 3 4 5 6.67 6.67 LOC127011 -0.32 -0.95 5.67 2.24 0.74 1 2 3 4 5 6.62 6.62 OR9Q1 5.70 0.02 6.60 -1.04 2.79 1 2 3 4 5 6.58 6.58 KLK5 -1.66 -1.18 5.36 -2.14 0.67 1 2 3 4 5 6.53 6.53 LOC653198 0.65 0.77 7.26 1.26 1.06 1 2 3 4 5 6.49 6.49 C11ORF40 -0.11 -1.23 5.22 1.70 -1.74 1 2 3 4 5 6.45 6.45 HS.563251 1.24 0.60 7.02 0.57 2.15 1 2 3 4 5 6.43 6.43 XIRP1 0.49 -1.37 5.04 -0.74 0.97 1 2 3 4 5 6.41 6.41 APOBEC1 -0.35 0.81 7.18 3.71 -0.33 1 2 3 4 5 6.38 6.38 HS.566804 2.64 -0.74 5.63 0.13 -0.09 1 2 3 4 5 6.37 6.37 KIAA1841 1.57 -1.04 5.33 -0.96 0.57 1 2 3 4 5 6.36 6.36 HS.542929 0.75 -0.55 5.67 1.72 -0.83 1 2 3 4 5 6.22 6.22 LOC642344 0.27 0.06 6.24 0.07 0.43 1 2 3 4 5 6.18 6.18 HS.545282 2.12 2.60 8.78 1.07 -0.08 1 2 3 4 5 6.18 6.18 C90RF27 1.31 -1.87 4.30 3.57 -0.62 1 2 3 4 5 6.17 6.17 Table 3 43 HS.561208 2.63 -0.34 5.81 2.72 2.46 1 2 3 4 5 6.15 6.15 NHEJ1 -0.20 -0.55 5.56 -0.56 0.75 1 2 3 4 5 6.11 6.11 MTMR7 1.16 0.30 6.37 -0.65 0.97 1 2 3 4 5 6.08 6.08 PYDC1 0.50 -0.77 5.30 -0.42 1.59 1 2 3 4 5 6.06 6.06 PGR -0.08 -0.67 5.36 -1.01 2.52 1 2 3 4 5 6.02 6.02 ADH1C 6.17 -0.88 5.09 -2.15 -1.75 1 2 3 4 5 5.97 5.97 HS.554066 0.29 -0.87 5.06 -0.45 -0.35 1 2 3 4 5 5.93 5.93 LOC646818 -0.89 -1.05 4.83 4.56 1.71 1 2 3 4 5 5.88 5.88 OR8B8 0.01 -0.42 5.46 4.14 0.82 1 2 3 4 5 5.88 5.88 HS.567194 -0.17 -1.04 4.83 -1.83 0.12 1 2 3 4 5 5.87 5.87 OR10A5 4.98 -1.77 4.07 1.38 1.07 1 2 3 4 5 5.84 5.84 C20ORF186 -0.27 -1.22 4.60 0.29 0.38 1 2 3 4 5 5.82 5.82 OR10X1 -1.85 0.30 6.11 -0.70 3.24 1 2 3 4 5 5.81 5.81 HS.563859 -1.01 0.50 6.30 0.29 -1.06 1 2 3 4 5 5.80 5.80 HS.536420 0.56 -0.48 5.31 2.90 1.20 1 2 3 4 5 5.80 5.80 OR9Q2 1.33 -1.29 4.48 -0.45 1.01 1 2 3 4 5 5.77 5.77 FU12684 1.20 -0.81 4.96 -1.08 3.55 1 2 3 4 5 5.77 5.77 HS.151117 5.33 -0.51 5.26 1.68 0.07 1 2 3 4 5 5.77 5.77 HS.308802 -0.84 -1.01 4.75 1.50 0.18 1 2 3 4 5 5.76 5.76 HS.201778 -0.17 -0.58 5.18 -0.36 0.89 1 2 3 4 5 5.76 5.76 HS.543658 1.04; 0.66 6.41 1.56 -0.79 1 2 3 4 5 5.75 5.75 DAB1 -0.62 -1.27 4.47 -2.09 1.80 1 2 3 4 5 5.74 5.74 H2AFB3 -0.35 -3.51 2.23 0.92 0.23 1 2 3 4 5 5.74 5.74 OR6A2 -0.83 -0.23 5.50 0.45 -0.33 1 2 3 4 5 5.73 5.73 HS.564626 1.03 -0.15 5.56 -0.05 0.70 1 2 3 4 5 5.71 5.71 ZNF595 5.45 -1.37 4.32 -0.45 1.51 1 2 3 4 5 5.69 5.69 CEP97 0.12 1.97 7.60 1.99 3.36 1 2 3 4 5 5.63 5.63 HS.544034 -0.07; -0.37 5.21 1.38 -0.57 1 2 3 4 5 5.58 5.58 HS.125977 -0.11 -0.53 5.05 0.31 -0.21 1 2 3 4 5 5.58 5.58 HS.538799 -0.75 -0.23 5.34 -0.82 -0.32 1 2 3 4 5 5.57 5.57 HS.528201 0.94 0.84 6.35 1.64 -0.28 1 2 3 4 5 5.51 5.51 UBE2S 1.56; -1.88 3.61 -1.44 -0.96 1 2 3 4 5 5.49 5.49 HS.568802 4.06 -0.95 4.54 0.68 -0.62 1 2 3 4 5 5.49 5.49 SMTNL2 1.22 -1.20 4.29 -1.57 1.47 1 2 3 4 5 5.48 5.48 HS.576760 -0.59; 1.52 6.97 0.82 -0.03 1 2 3 4 5 5.45 5.45 PCDHB7 -0.16 -0.88 4.57 -0.73 -0.09 1 2 3 4 5 5.45 5.45 LOC651597 2.38: -0.79 4.64 0.43 -1.09 1 2 3 4 5.43 5.43 PLD5 0.72 -1.49 3.94 -0.67 -1.66 1 2 3 4 5 5.43 5.43 HS.544512 0.80 1.37 6.79 -0.78 0.23 1 2 3 4 5 5.42 5.42 HS.553468 5.75 -0.56 4.86 0.97 0.40 1 2 3 4 5 5.42 5.42 HS.538028 4.07; 1.39 6.81 0.34 0.02 1 2 3 4 5 5.42 5.42 SPRR1A -0.90 -0.50 4.90 2.80 -0.42 1 2 3 4 5 5.40 5.40 HS.125904 0.70 -0.18 5.22 0.25 0.53 1 2 3 4 5 5.40 5.40 HS.580621 1.84 -1.85 3.54 -0.94 -0.30 1 2 3 4 5 5.39 5.39 LOC123876 -0.69 0.27 5.66 1.83 -1.39 1 2 3 4 5 5.39 5.39 SLC17A1 1.84 0.28 5.66 -0.56 -0.98 1 2 3 4 5 5.38 5.38 SCARA3 -0.43 -0.06 5.28 -0.48 -1.05 1 2 3 4 5 5.34 5.34 LBX1 -0.30 -1.62 3.71 1.32 -0.81 1 2 3 4 5 5.33 5.33 LOC649360 -1.83 -1.90 3.39 -0.81 3.62 1 2 3 4 5 5.29 5.29 Table 3 44 LOC651834 3.32 -0.50 4.77 0.29 0.43 1 2 3 4 5 5.27 5.27 HS.572920 -0.21 1.78 7.04 -0.43 -0.15 1 2 3 4 5 5.26 5.26 LOC643261 1.00 -0.24 5.00 -0.33 -0.45 1 2 3 4 5 5.24 5.24 LOC653830 -1.29 0.03 5.27 0.42 3.54 1 2 3 4 5 5.24 5.24 XKRY 0.55 -1.10 4.13 1.66 -0.64 1 2 3 4 5 5.24 5.24 C100RF115 1.15 -3.18 2.05 3.72 1.24 1 2 3 4 5 5.22 5.22 LOC651102 0.42 -0.31 4.91 -1.11 -0.86 1 2 3 4 5 5.22 5.22 HS.544643 -0.90 -0.74 4.45 -0.26 -0.29 1 2 3 4 5 5.20 5.20 LOC402716 -0.71 -1.07 4.10 -1.38 0.64 1 2 3 4 5 5.17 5.17 HS.130639 0.64 -0.46 4.69 0.19 0.80 1 2 3 4 5 5.15 5.15 HS.104677 0.00 2.79 7.93 2.83 -0.76 1 2 3 4 5 5.14 5.14 GC -0.22 -0.21 4.91 -0.61 -0.20 1 2 3 4 5 5.11 5.11 HS.121383 5.21 -0.45 4.66 0.87 0.50 1 2 3 4 5 5.11 5.11 LOC644215 -0.26 -0.69 4.40 -0.60 0.16 1 2 3 4 5 5.09 5.09 LOC389936 0.13 -0.23 4.84 1.44 -0.21 1 2 3 4 5 5.07 5.07 HS.541613 3.94 2.49 7.54 0.17 -0.64 1 2 3 4 5 5.05 5.05 RIMBP2 1.57 0.62 5.66 0.57 -0.39 1 2 3 4 5 5.03 5.03 FU25328 0.89 -0.89 4.14 1.49 0.25 1 2 3 4 5 5.03 5.03 CAPN13 -1.21 -1.10 3.90 1.70 -0.35 1 2 3 4 5 5.01 5.01 HS.128577 -0.63 2.59 7.59 -0.03 0.91 1 2 3 4 5 5.00 5.00 HS.583099 -0.61 0.08 5.05 1.95 0.80 1 2 3 4 5 4.97 4.97 IFNA2 -0.55 -0.24 4.72 -0.19 0.85 1 2 3 4 5 4.96 4.96 HS.436662 -0.79 1.70 6.64 -0.02 -1.19 1 2 3 4 5 4.95 4.95 TFF1 -0.54 -0.90 4.04 0.60 -1.03 1 2 3 4 5 4.94 4.94 IL13RA2 -0.43 -0.78 4.16 0.52 0.18 1 2 3 4 5 4.93 4.93 HS.571177 1.62 0.61 5.55 1.64 4.13 1 2 3 4 5 4.93 4.93 HS.127144 5.52 1.18 6.11 -0.34 0.58 1 2 3 4 5 4.93 4.93 HS.562174 -0.58 0.75 5.65 0.30 1.39 1 2 3 4 5 4.90 4.90 TPRX1 1.19 -1.78 3.10 -1.43 0.49 1 2 3 4 5 4.88 4.88 LOC654208 -0.41 0.45 5.32 -0.08 0.96 1 2 3 4 5 4.87 4.87 RASEF -0.10 2.05 6.92 0.71 1.84 1 2 3 4 5 4.86 4.86 HS.555239 1.47 -0.55 4.30 0.44 0.30 1 2 3 4 5 4.85 4.85 HS.241546 0.08 -0.02 4.82 1.40 3.01 1 2 3 4 5 4.84 4.84 GSX2 -0.25 -0.83 4.00 -1.29 -1.97 1 2 3 4 5 4.83 4.83 BAI3 1.06 -0.38 4.45 -0.60 4.38 1 2 3 4 5 4.83 4.83 HS.566169 -0.48 -1.77 3.06 0.42 -1.71 1 2 3 4 5 4.83 4.83 LOC646266 -1.04 ; -0.41 4.42 -1.21 -0.03 1 2 3 4 5 4.83 4.83 HS.576547 -0.12 0.27 5.07 -0.33 1.14 1 2 3 4 5 ; 4.80 4.80 KRTAP15-1 0.65 ; -0.58 4.22 -0.70 0.04 1 2 3 4 5 4.79 4.79 HS.561669 1.43 -0.78 4.00 6.15 -0.46 1 2 3 4 5 4.78 4.78 HS.532032 4.20 0.95 5.73 1.42 -0.74 1 2 3 4 5 4.78 4.78 HS.566519 1.59 -0.91 3.86 -0.31 1.51 1 2 3 4 5 4.77 4.77 CIB4 0.55 -1.20 3.56 0.67 0.58 1 2 3 4 5 4.77 4.77 HS.336475 1.41 2.28 7.05 -0.71 1.84 1 2 3 4 5 4.77 4.77 GUCY2F -0.53 -0.28 4.48 -0.30 0.30 1 2 3 4 5 4.76 4.76 HS.446289 -0.35 -0.81 3.93 1.28 1.07 1 2 3 4 4.74 4.74 ZPLD1 -1.95 -3.05 1.63 3.14 0.54 1 2 3 4 5 4.68 4.68 LOC643430 0.66 0.32 4.98 -1.06 1.35 1 2 3 4 5 4.66 4.66 LOC653129 -0.84 0.64 5.29 -1.07 1.44 1 2 3 4 5 4.66 4.66 Table 3 45 HS.542179 -1.02 -1.01 3.65 0.86 -0.08 1 2 3 4 5 4.66 4.66 DEFB112 -0.42 0.33 4.97 0.52 1.70 1 2 3 4 5 4.64 4.64 RSP04 -0.17 -0.09 4.55 -0.36 1.75 1 2 3 4 5 4.64 4.64 GLTPD2 -0.95 -0.98 3.65 0.81 1.18 1 2 3 4 5 4.63 4.63 HS.546026 6.53 1.15 5.75 2.74 1.85 1 2 3 4 5 4.61 4.61 FBX047 1.42 -0.60 3.99 0.76 -2.34 1 2 3 4 5 4.59 4.59 HS.543831 1.70 -0.46 4.13 1.58 0.78 1 2 3 4 5 4.59 4.59 LOC730194 0.90 0.01 4.58 0.22 2.32 1 2 3 4 5 4.58 4.58 APOBEC4 -1.27 1.20 5.78 0.15 -1.38 1 2 3 4 5 4.58 4.58 HS.568589 0.62 -0.66 3.91 -0.64 -0.22 1 2 3 4 5 4.57 4.57 HS.561391 1.93 0.11 4.66 -0.62 2.28 1 2 3 4 5 4.55 4.55 HS.147106 -0.52 -0.19 4.35 -0.20 0.73 1 2 3 4 5 4.54 4.54 HS.552885 1.78 1.74 6.26 -0.12 0.01 1 2 3 4 5 4.52 4.52 LOC441205 -0.34 0.35 4.86 2.86 0.15 1 2 3 4 5 4.52 4.52 FGF7 -0.06 -1.78 2.74 -0.13 0.22 1 2 3 4 5 4.52 4.52 HS.567198 0.50 -1.82 2.69 -0.69 0.01 1 2 3 4 5 4.51 4.51 HS.437005 -0.75 0.31 4.81 1.56 2.08 1 2 3 4 5 4.50 4.50 OC90 -0.56 0.08 4.55 -1.10 -0.49 1 2 3 4 5 4.47 4.47 HS.506265 4.01 0.87 5.30 4.14 0.83 1 2 3 4 5 4.43 4.43 HS.571795 -1.11 -0.82 3.58 0.32 0.25 1 2 3 4 5 4.41 4.41 SLC17A8 0.23, -0.71 3.69 0.20 -1.31 1 2 3 4 5 4.40 4.40 LOC650553 0.03 -0.57 3.82 -0.17 -1.05 1 2 3 4 5 4.39 4.39 HS.544505 0.81 0.28 4.66 -0.77 1.53 1 2 3 4 5 4.38 4.38 FOXN1 3.29 -0.08 4.30 1.82 0.17 1 2 3 4 5 4.38 4.38 HS.575829 1.47 0.44 4.82 0.17 -0.18 1 2 3 4 5 4.38 4.38 HS.567200 0.69; -1.43 2.95 1.46 0.90 1 2 3 4 5 4.38 4.38 LOC339799 0.57 -1.14 3.23 -0.67 0.10 1 2 3 4 5 4.37 4.37 HS.566773 5.61 -1.10 3.27 1.03 1.38 1 2 3 4 5 4.37 4.37 LOC401131 -0.36 -0.42 3.94 0.16 1.61 1 2 3 4 5 4.36 4.36 HS.514919 2.07 -0.43 3.93 0.02 1.71 1 2 3 4 5 4.36 4.36 LOC402634 0.27 -0.56 3.77 3.99 2.86 1 2 3 4 5 4.33 4.33 GRHL3 2.52 -0.43 3.89 -0.64 0.23 1 2 3 4 5 4.32 4.32 HS.148993 4.73; -1.41 2.91 2.31 -0.82 1 2 3 4 5 4.31 4.31 HS.554463 -0.28 1.12 5.43 2.48 0.17 1 2 3 4 5 4.30 4.30 LOC652156 -0.84 0.46 4.76 1.35 3.50 1 2 3 4 5 4.30 4.30 HS.561962 -0.28 0.41 4.70 0.67 0.89 1 2 3 4 5 4.29 4.29 TRPM8 0.50 -0.25 4.02 -0.54 2.10 1 2 3 4 5 4.28 4.28 HS.542835 -0.51 -0.64 3.63 0.54 0.28 1 2 3 4 5 4.27 4.27 LOC645951 -0.51 -0.57 3.71 -0.10 0.12 1 2 3 4 4.27 4.27 DAND5 1.41 -0.33 3.93 0.21 -0.64 1 2 3 4 5 4.27 4.27 TAS1R2 1.94 0.48 4.74 0.26 -0.23 1 2 3 4 5 4.26 4.26 HS.131071 -0.66 -0.07 4.18 1.48 -0.34 1 2 3 4 5 4.25 4.25 LOC650014 -0.27 3.21 7.45 0.35 -0.07 1 2 3 4 5 4.24 4.24 LOC651189 -0.17 -1.11 3.13 -0.36 0.49 1 2 3 4 5 4.24 4.24 HS.224454 0.14 -0.50 3.74 1.15 -0.50 1 2 3 4 5 4.23 4.23 HS.565679 0.55 0.87 5.10 0.10 -0.24 1 2 3 4 5 4.23 4.23 HS.475678 -0.56 -0.77 3.45 -0.42 -0.43 1 2 3 4 5 4.22 4.22 FU43763 -1.10 -0.45 3.75 0.36 0.03 1 2 3 4 5 4.20 4.20 COL1A2 0.98 -0.32 3.88 0.01 0.85 1 2 3 4 5 4.20 4.20 Table 3 SOHLH1 -0.28 0.76 4.95 2.09 1.08 1 2 3 4 5 4.19 4.19 TMEM200B -0.02 -0.83 3.36 3.49 0.39 1 2 3 4 5 4.18 4.18 GJD2 0.57 -0.63 3.55 1.34 -0.09 1 2 3 4 5 4.18 4.18 KBTBD5 0.40 -1.91 2.27 -1.61 2.29 1 2 3 4 5 4.18 4.18 LOC644372 0.25 -1.10 3.08 -0.32 1.40 1 2 3 4 5 4.17 4.17 HS.544457 1.38 -0.70 3.47 -0.61 0.22 1 2 3 4 5 4.17 4.17 HS.537994 -0.24 -0.35 3.81 0.78 0.32 1 2 3 4 5 4.16 4.16 GPD1 -0.71; -0.34 3.82 -0.86 -0.95 1 2 3 4 5 4.16 4.16 NLF2 -0.72 -1.20 2.96 -0.85 -1.70 1 3 4 5 4.16 4.16 HS.539753 1.51 -1.80 2.33 0.50 2.42 1 2 3 4 5 4.13 4.13 FRG2B 5.06 -0.73 3.39 0.84 -1.13 1 2 3 4 5 4.13 4.13 ZNF710 -0.44 0.14 4.26 0.56 -0.17 1 2 3 4 5 4.12 4.12 HS.458733 -0.53 1.60 5.72 0.16 0.57 1 2 3 4 5 4.12 4.12 OR9A4 -1.33 -1.21 2.90 1.30 -1.13 1 2 3 4 5 4.12 4.12 HS.543422 0.86 -0.59 3.51 -0.14 0.06 1 2 3 4 5 4.10 4.10 TYRP1 -0.21 -1.81 2.28 -0.14 -0.22 1 2 3 4 5 4.09 4.09 HS.540155 1.99 1.24 5.31 2.24 1.73 1 2 3 4 5 4.08 4.08 REG3A -0.23 -0.83 3.23 -0.66 -0.77 1 2 3 4 5 4.06 4.06 HS.523484 1.03 0.09 4.14 -2.22 1.45 1 2 3 4 5 4.06 4.06 MLNR 0.72 0.63 4.68 0.12 0.35 1 2 3 4 5 4.05 4.05 GREM2 0.12 -0.13 3.91 -0.16 -0.64 1 2 3 4 5 4.04 4.04 TAKR 1.04 -0.52 3.51 1.01 0.82 1 2 3 4 5 4.03 4.03 HS.541362 0.19 2.49 6.50 -0.86 -1.02 1 2 3 4 5 4.02 4.02 CNBD1 -0.14 ! -2.04 1.97 4.09 1.32 1 2 3 4 5 4.01 4.01 RAB17 0.11 -0.98 3.03 1.22 -0.50 1 2 3 4 5 4.01 4.01 OR5B17 0.15 -0.17 3.85 1.34 -0.58 1 2 3 4 5 4.01 4.01 FOXD4L3 -0.68; -0.48 3.53 -0.32 -0.41 1 2 3 4 5 4.01 4.01 HS.581297 -0.75; -1.00 3.01 0.26 0.90 1 2 3 4 5 4.01 4.01 LOC439914 0.71 -1.26 2.75 -0.88 0.75 1 2 3 4 5 4.00 4.00 C140RF178 4.56 0.88 4.87 1.70 0.70 1 2 3 4 5 3.99 3.99

SPANXN5 2.38 ! 1.76 5.75 0.60 1.01 1 2 3 4 5 3.99 3.99 LOC652540 0.20 -0.23 3.75 3.20 1.55 1 2 3 4 5 3.98 3.98 HS.112731 0.04 -0.51 3.46 -0.63 -0.40 1 2 3 4 5 3.98 3.98 ZNF678 2.54 -3.28 0.69 1.31 3.13 1 2 3 4 5 3.97 3.97 HS.434903 0.32 -0.73 3.23 0.44 -0.36 1 2 3 4 5 3.96 3.96 LOC650804 0.31; 0.01 3.96 -0.16 0.24 1 2 3 4 5 3.95 3.95 CAMK2A -0.86! 0.75 4.69 -1.49 -0.24 1 2 3 4 5 3.94 3.94 HS.563050 -0.42! -0.51 3.42 -0.38 0.52 1 2 3 4 5 3.93 3.93 DSCR9 1.09: 1.01 4.94 -0.55 1.12 1 2 3 4 5 3.93 3.93 HS.183041 1.47 -0.87 3.06 2.96 1.07 1 2 3 4 5 3.93 3.93 HS.577215 1.89 0.82 4.73 -0.29 0.56 1 2 3 4 5 3.92 3.92 LOC645093 -0.08 -0.49 3.43 0.13 0.87 1 2 3 4 5 3.91 3.91 HS.541995 -0.23 2.48 6.39 -0.76 0.36 1 2 3 4 5 3.91 3.91 HS.128812 4.20 -0.23 3.68 0.48 1.24 1 2 3 4 5 3.91 3.91 OR5H15 -0.08 -0.82 3.07 0.64 2.06 1 2 3 4 5 3.89 3.89 FU42102 -1.10 -0.46 3.43 -1.30 2.01 1 2 3 4 5 3.89 3.89 BRDT 1.05 -0.39 3.50 3.55 0.61 1 2 3 4 5 3.88 3.88 LOC646055 1.96 -1.24 2.63 2.31 -0.49 1 2 3 4 5 3.87 3.87 HS.543411 2.13 -0.72 3.15 0.36 -0.54 1 2 3 4 5 3.87 3.87 Table 3 47 HS.540298 0.10 -1.21 2.66 -0.58 1.00 1 2 3 4 5 3.87 3.87 PLA1A -0.79 -0.03 3.84 -0.30 0.56 1 2 3 4 5 3.87 3.87 HS.539487 -1.97 -0.33 3.53 -1.57 -0.53 1 2 3 4 3.87 3.87 ARHGEF16 -0.91 -0.96 2.90 -0.24 -1.39 1 2 3 4 5 3.86 3.86 HS.565362 4.95 1.17 5.03 1.40 0.21 1 2 3 4 5 3.86 3.86 HS.540138 2.33 0.23 4.08 4.48 0.50 1 2 3 4 5 3.85 3.85 CD5L -0.75 -1.01 2.84 -0.52 -0.62 1 2 3 4 5 3.85 3.85 LOC442208 1.37 2.02 5.86 -0.01 0.19 1 2 3 4 5 3.83 3.83 A2BP1 1.99 -0.03 3.80 2.67 2.03 1 2 3 4 5 3.83 3.83 SULT1C2 -0.44 0.58 4.41 2.12 2.98 1 2 3 4 5 3.83 3.83 HS.285193 0.05 -0.78 3.04 -0.08 0.50 1 2 3 4 5 3.82 3.82 HS.574267 1.64 -0.72 3.09 1.75 0.48 1 2 3 4 5 3.81 3.81 DEFB121 1.14 1.83 5.64 0.40 0.77 1 2 3 4 5 3.81 3.81 LOC154449 1.76 -0.31 3.50 0.60 0.37 1 2 3 4 5 3.81 3.81 HS.566755 3.78 -0.13 3.67 -0.52 -0.82 1 2 3 4 5 3.81 3.81 HS.570661 1.36 -0.59 3.21 1.53 -0.56 1 2 3 4 5 3.80 3.80 HS.195052 2.26 -1.09 2.70 0.71 0.75 1 2 3 4 5 3.79 3.79 OR13C8 -1.21 -1.94 1.85 -0.51 -1.21 1 2 3 4 5 3.79 3.79 LOC284064 0.40 -0.13 3.66 -0.47 -0.12 1 2 3 4 5 3.79 3.79 AGBL1 2.53 -0.80 2.98 2.30 -0.49 1 2 3 4 5 3.78 3.78 DKFZP781G0119 0.18 0.47 4.25 2.56 -0.36 1 2 3 4 5 3.78 3.78 HS.578090 0.68 -1.92 1.86 -1.53 -1.06 1 2 3 4 5 3.78 3.78 TCF7L1 -0.40 -1.19 2.59 -0.23 0.45 1 2 3 4 5 3.78 3.78 LOC648792 3.84 -2.06 1.70 1.59 -2.04 1 2 3 4 5 3.76 3.76 LOC652405 -0.35 -0.20 3.56 0.19 2.26 1 2 3 4 5 3.76 3.76 HS.573834 -0.11 0.79 4.55 4.89 -0.97 1 2 3 4 5 3.76 3.76 HS.212794 0.86 1.83 5.58 -0.09 3.10 1 2 3 4 5 3.75 3.75 WISP2 2.94 1.96 5.71 0.57 2.73 1 2 3 4 5 3.75 3.75 KRT25 -0.57 -0.84 2.90 -0.02 2.83 1 2 3 4 5 3.74 3.74 HS.554473 2.05 1.08 4.81 3.02 0.77 1 2 3 4 5 3.73 3.73 HS.335305 -0.47 -0.64 3.09 -0.63 1.38 1 2 3 4 5 3.73 3.73 HS.537638 -0.06 -0.33 3.38 0.80 -0.33 1 2 3 4 5 3.70 3.70 LOC649524 -0.58 2.48 6.18 0.49 -0.02 1 2 3 4 5 3.70 3.70 CTNNA3 -1.59 -1.81 1.89 1.69 -0.78 1 2 3 4 5 3.70 3.70 HS.436361 3.07 -0.17 3.53 1.25 0.06 1 2 3 4 5 3.70 3.70 CAMKV 0.40 -0.45 3.24 -0.36 0.16 1 2 3 4 5 3.70 3.70 HIST1H4L -0.58 -1.41 2.27 0.37 3.49 1 2 3 4 5 3.68 3.68 RLBP1L1 -0.24 -0.89 2.80 -0.15 -0.76 1 2 3 4 5 3.68 3.68 HS.566775 -1.55 -0.01 3.67 1.69 0.00 1 2 3 4 5 3.68 3.68 HS.571075 0.32 0.08 3.76 -0.20 0.53 1 2 3 4 5 3.68 3.68 LOC644208 -0.59 -0.71 2.96 -0.47 1.76 1 2 3 4 5 3.67 3.67 HS.558017 1.39 -1.57 2.10 -0.92 -0.28 1 2 3 4 5 3.67 3.67 LOC646376 -0.10 -0.03 3.64 0.53 -0.13 1 2 3 4 5 3.67 3.67 HS.129478 0.73 1.36 5.03 -0.53 -0.39 1 2 3 4 5 3.67 3.67 SNORD42A 0.60 -1.50 2.16 5.12 1.39 1 2 3 4 5 3.67 3.67 LOC651986 -0.86 -1.44 2.21 2.12 -0.42 1 2 3 4 5 3.65 3.65 FAM22G -1.06 -0.84 2.80 -1.10 2.12 1 2 3 4 5 3.64 3.64 GSX1 0.07 -0.77 2.87 2.07 2.54 1 2 3 4 5 3.63 3.63 LOC392196 -0.18 0.45 4.08 -0.14 -1.45 1 2 3 4 5 3.63 3.63 Table 3 48 HS.554329 -0.67 -0.92 2.70 -0.12 0.50 1 2 3 4 5 3.63 3.63 DCDC2 -0.54 -0.32 3.30 1.58 -0.16 1 2 3 4 5 3.62 3.62 LOC648240 0.53 -1.23 2.39 -0.65 -0.13 1 2 3 4 5 3.62 3.62 HS.537363 0.37 1.58 5.20 1.79 0.52 1 2 3 4 5 3.62 3.62 HS.538727 0.78 -0.43 3.19 -0.80 0.09 1 2 3 4 5 3.62 3.62 OSTALPHA -0.23 -0.85 2.76 -1.05 0.25 1 2 3 4 5 3.62 3.62 CDH18 -1.17 -0.74 2.86 0.87 0.19 1 2 3 4 5 3.61 3.61 TBX4 -0.12 -1.23 2.37 1.16 -0.17 1 2 3 4 5 3.60 3.60 HS.562792 -0.17 -0.34 3.25 -0.45 -0.30 1 2 3 4 5 3.60 3.60 HS.300217 -0.18 -0.42 3.18 2.42 1.74 1 2 3 4 5 3.60 3.60 HS.385774 0.67 -0.99 2.60 1.18 0.07 1 2 3 4 5 3.60 3.60 HS.334126 0.78 0.89 4.48 -0.46 -0.41 1 2 3 4 5 3.59 3.59 HS.201511 -1.13 0.79 4.38 0.41 1.13 1 2 3 4 5 3.59 3.59 FOXA3 0.77 -0.38 3.20 1.47 0.48 1 2 3 4 5 3.58 3.58 HS.156213 -0.37 0.08 3.65 5.09 -0.86 1 2 3 4 5 3.57 3.57 LOC647413 -0.96 -0.99 2.58 -0.21 0.08 1 2 3 4 5 3.57 3.57 FU45717 0.97 3.88 7.44 -0.63 -0.36 1 2 3 4 5 3.56 3.56 MY015A -0.10 -1.10 2.46 0.56 -0.73 1 2 3 4 5 3.56 3.56 HS.550709 -0.25 -0.61 2.95 -0.43 -0.27 1 2 3 4 5 3.56 3.56 MGC15885 -0.10 -0.58 2.98 0.08 1.61 1 2 3 4 5 3.55 3.55 HS.544115 0.68 -0.98 2.56 1.21 3.28 1 2 3 4 5 3.54 3.54 HS.201220 0.84 -0.56 2.98 1.19 -0.92 1 2 3 4 5 3.54 3.54 HS.163517 -0.03 3.11 6.65 6.82 2.04 1 2 3 4 5 3.54 3.54 HS.574226 0.17 0.71 4.24 3.94 -1.12 1 2 3 4 5 3.53 3.53 HS.415414 1.09; -0.04 3.50 -1.69 -0.02 1 2 3 4 5 3.53 3.53 GJA10 -0.33 -0.46 3.06 -1.05 -0.58 1 2 3 4 5 3.52 3.52 HS.580497 3.18 -1.11 2.41 0.05 -0.54 1 2 3 4 5 3.52 3.52 HS.560050 4.25 -0.56 2.95 -0.90 2.25 1 2 3 4 5 3.51 3.51 LOC646933 0.07 1.00 4.51 -0.64 1.89 1 2 3 4 5 3.51 3.51 LOC644005 -0.35' 0.30 3.81 -1.45 -0.21 1 2 3 4 5 3.51 3.51 TMEM139 0.14 -1.12 2.38 -0.95 -0.80 1 2 3 4 5 3.50 3.50 LOC645552 -0.05 2.71 6.22 1.65 1.03 1 2 3 4 5 3.50 3.50 HS.544896 1.59 0.40 3.90 5.01 -0.52 1 2 3 4 5 3.50 3.50 HS.550430 -0.35 2.89 6.38 -0.60 0.07 1 2 3 4 5 3.50 3.50 LOC653217 -1.24 -0.68 2.82 2.01 0.39 1 2 3 4 5 3.49 3.49 UNC5D -0.67 -0.10 3.38 0.12 0.85 1 2 3 4 5 3.49 3.49 HS.542610 1.03 0.13 3.62 0.88 -0.32 1 2 3 4 5 3.48 3.48 HS.572594 -0.30 -0.19 3.29 -0.18 0.07 1 2 3 4 5 3.48 3.48 COL25A1 1.16 0.66 4.14 0.13 2.25 1 2 3 4 5 3.48 3.48 HS.178144 4.69 2.05 5.52 0.29 -0.47 1 2 3 4 5 3.47 3.47 OR2Y1 1.68 -0.62 2.85 0.85 -0.88 1 2 3 4 5 3.47 3.47 DEFA6 1.04 -1.13 2.34 3.52 -0.93 1 2 3 4 5 3.47 3.47 HS.199755 -0.04 -1.17 2.29 -0.57 0.17 1 2 3 4 5 3.47 3.47 LOC650557 -0.36 0.35 3.82 2.48 1.34 1 2 3 4 5 3.46 3.46 LOC644399 -0.31 -0.69 2.77 -0.13 -0.40 1 2 3 4 5 3.46 3.46 OR6C68 0.91 -0.99 2.47 0.72 2.03 1 2 3 4 5 3.46 3.46 LOC644921 0.27 -0.07 3.38 -0.93 -0.27 1 2 3 4 5 3.46 3.46 LOC645721 -0.62 -0.06 3.40 -0.64 0.07 1 2 3 4 5 3.45 3.45 OR1L6 -0.79 -0.93 2.53 1.25 -0.44 1 2 3 4 5 3.45 3.45 Table 3 49 RPL10 -0.36 -0.70 2.75 1.26 0.53 1 2 3 4 5 3.45 3.45 HS.582621 1.66 -0.68 2.76 -0.13 2.99 1 2 3 4 5 3.45 3.45 HS.146126 3.79 -0.40 3.05 -0.72 0.32 1 2 3 4 5 3.45 3.45 HS.149361 1.32 0.34 3.78 -0.67 4.04 1 2 3 4 5 3.44 3.44 WBSCR23 -1.97 -0.76 2.68 0.60 -0.60 1 2 3 4 5 3.44 3.44 ADAMTS3 -0.93 -1.30 2.14 0.86 2.28 1 2 3 4 5 3.44 3.44 HS.544540 2.85 0.10 3.54 -0.37 -0.23 1 2 3 4 5 3.44 3.44 HS.563113 -0.58 -0.24 3.19 -0.32 -0.61 1 2 3 4 5 3.44 3.44 HS.210382 -0.68 0.39 3.82 -0.83 0.54 1 2 3 4 5 3.43 3.43 HS.439512 1.28 -0.89 2.54 3.46 -0.32 1 2 3 4 5 3.43 3.43 HS.565471 0.72 -0.65 2.77 -0.25 -0.51 1 2 3 4 5 3.43 3.43 LOC642851 0.49 1.21 4.64 -0.52 3.11 1 2 3 4 5 3.42 3.42 HS.543056 -0.31 -0.68 2.74 - .26 0.59 1 2 3 4 5 3.42 3.42 ADAD1 -1.52 -0.68 2.74 3.57 1.43 1 2 3 4 5 3.42 3.42 HS.195044 -1.47 -1.77 1.64 -0.71 -0.74 1 2 3 4 5 3.41 3.41 HS.545873 1.19 -0.44 2.97 1.40 -0.25 1 2 3 4 5 3.41 3.41 HS.104990 -0.16 -1.08 2.32 1.21 0.62 1 2 3 4 5 3.40 3.40 NCAPH -0.54 -0.85 2.55 -0.42 -0.78 1 2 3 4 5 3.40 3.40 HS.147224 4.04 -1.46 1.93 0.99 1.40 1 2 3 4 5 3.39 3.39 UNQ9370 -0.46 -0.48 2.91 -0.62 -0.40 1 2 3 4 5 3.39 3.39 RBPMS 3.21 0.99 4.37 -0.34 1.02 1 2 3 4 5 3.39 3.39 FEZF1 5.70 -2.15 1.23 -1.07 0.14 1 2 3 4 5 3.38 3.38 SSTR1 -0.58 -0.48 2.90 0.57 -0.19 1 2 3 4 5 3.38 3.38 HS.526617 1.09 2.25 5.63 1.61 2.05 1 2 3 4 5 3.38 3.38 STELLAR -0.25 -1.12 2.26 0.29 -0.76 1 2 3 4 5 3.37 3.37 LOC642106 0.14 -0.05 3.31 -1.19 3.74 1 2 3 4 5 3.36 3.36 KLK12 0.26 -0.92 2.43 0.45 -0.89 1 2 3 4 5 3.35 3.35 MY015B 0.98 -0.14 3.21 1.15 0.17 1 2 3 4 5 3.35 3.35 SPANXC -1.47 1.45 4.80 -1.76 0.35 1 2 3 4 5 3.35 3.35 KIAA0644 2.85 -0.43 2.91 0.18 1.02 1 2 3 4 5 3.34 3.34 LOC647706 0.78 -0.99 2.36 -0.31 0.11 1 2 3 4 3.34 3.34 HS.565984 0.25 0.32 3.66 1.66 0.31 1 2 3 4 5 3.34 3.34 HS.570257 0.23 -1.18 2.16 0.85 -0.53 1 2 3 4 5 3.34 3.34 MMP13 1.10 -0.42 2.90 -1.01 -1.12 1 2 3 4 5 3.32 3.32 HS.540451 -1.34 1.04 4.36 1.89 0.08 1 2 3 4 5 3.32 3.32 DCD -0.58 -0.18 3.14 3.01 2.86 1 2 3 4 5 3.32 3.32 SLC37A2 -0.38 -3.02 0.28 -0.75 -0.48 1 2 3 4 5 3.31 3.31 MANEAL -0.42 -0.97 2.34 -1.16 -0.41 1 2 3 4 5 3.31 3.31 MGC33894 0.97 -1.00 2.30 -0.81 0.37 1 2 3 4 5 3.30 3.30 HS.201030 0.01 0.03 3.33 -0.83 0.27 1 2 3 4 5 3.29 3.29 CYP8B1 0.28 -0.52 2.77 -0.35 1.02 1 2 3 4 5 3.29 3.29 HS.537611 0.67 -0.53 2.76 -0.38 0.45 1 2 3 4 5 3.29 3.29 HS.434736 -1.21 -2.07 1.22 1.54 -1.02 1 2 3 4 5 3.29 3.29 ILIA 1.90 -0.94 2.35 -1.12 0.05 1 2 3 4 3.29 3.29 HS.577921 5.03 -0.47 2.82 1.98 0.84 1 2 3 4 5 3.29 3.29 SETD6 1.09 -2.35 0.94 -1.68 -0.05 1 2 3 4 5 3.29 3.29 LOC643734 -0.28 -0.95 2.33 2.11 3.87 1 2 3 4 5 3.29 3.29 C140RF177 0.05 -0.29 2.99 3.73 2.56 1 2 3 4 5 3.28 3.28 CCL21 0.71 -0.15 3.12 -0.23 -0.17 1 2 3 4 5 3.28 3.28 Table 3 50 LOC644504 -0.58 0.48 3.75 2.84 0.16 1 2 3 4 5 3.27 3.27 HS.529724 -0.69 -0.76 2.51 -0.98 -0.35 1 2 3 4 5 3.27 3.27 HS.584020 2.10 -0.27 3.00 0.40 -0.25 1 2 3 4 5 3.27 3.27 HS.405849 5.75 -0.47 2.80 0.48 3.44 1 2 3 4 5 3.27 3.27 NOVA1 1.60 -0.63 2.64 -0.18 -0.10 1 2 3 4 5 3.27 3.27 C10ORF90 -0.83 0.23 3.50 2.38 0.55 1 2 3 4 5 3.27 3.27 ANGPT4 -0.21 -1.89 1.37 -0.74 -0.93 1 2 3 4 5 3.26 3.26 ZNF267 -0.92 0.55 3.80 -0.46 -0.66 1 2 3 4 5 3.26 3.26 HS.151287 2.90 -1.61 1.65 -0.27 3.24 1 2 3 4 5 3.26 3.26 BOC 0.69 -0.07 3.18 1.16 0.18 1 2 3 4 5 3.26 3.26 LOC401507 0.93 0.98 4.24 3.55 2.60 1 2 3 4 5 3.26 3.26 TEAD3 -0.93 -0.60 2.65 -0.84 -0.23 1 2 3 4 5 3.25 3.25 OR5AR1 0.90 -0.79 2.46 -0.51 -0.58 1 2 3 4 5 3.25 3.25 LOC402096 -0.41 4.15 7.40 3.47 0.46 1 2 3 4 5 3.25 3.25 HS.551391 -0.11 2.73 5.98 2.56 0.47 1 2 3 4 5 3.25 3.25 LOC644099 -0.70 0.62 3.87 0.93 -0.54 1 2 3 4 5 3.24 3.24 CPA6 5.72 -0.88 2.36 0.23 -0.89 1 2 3 4 5 3.24 3.24 HS.253815 -0.78 -0.79 2.45 -0.63 0.12 1 2 3 4 5 3.24 3.24 SLURP1 -0.91 -1.28 1.95 2.39 0.35 1 2 3 4 5 3.23 3.23 SCGB1D4 -1.71 -1.45 1.78 -1.95 -1.44 1 2 3 4 5 3.23 3.23 SOX1 1.10 -0.68 2.55 -0.62 -0.79 1 2 3 4 5 3.23 3.23 LOC644593 -0.04 -0.48 2.75 1.54 1.26 1 2 3 4 5 3.22 3.22 SYT1 0.64 0.32 3.53 0.30 2.22 1 2 3 4 5 3.22 3.22 LOC399706 -0.26 2.89 6.10 0.40 -0.84 1 2 3 4 5 3.22 3.22 ΤΤΤΎ9Α -1.02 0.09 3.30 -0.02 1.25 1 2 3 4 5 3.21 3.21 7A5 -1.27 -0.28 2.93 0.06 0.74 i 2 3 4 5 3.21 3.21 CACNG7 0.89 -0.17 3.04 -0.92 1.22 1 2 3 4 5 3.21 3.21 MLN -0.45 -1.22 1.99 -0.63 -0.45 1 2 3 4 5 3.21 3.21 HS.127905 -0.77 -0.37 2.84 -0.39 -0.51 1 2 3 4 5 3.21 3.21 PPP1R1A -0.35 -0.83 2.36 1.27 0.25 1 2 3 4 5 3.20 3.20 PRDM12 -0.93 -1.04 2.15 -1.66 -0.45 1 2 3 4 5 3.19 3.19 LOC652011 -1.94 -1.28 1.91 -0.89 1.49 1 2 3 4 5 3.19 3.19 WDR88 -1.77 -1.63 1.56 0.45 -0.23 1 2 3 4 5 3.19 3.19 HS.580465 1.97 -0.13 3.06 5.43 0.33 2 3 4 5 3.19 3.19 LOC642730 5.39 0.83 4.02 0.86 1.11 1 2 3 4 5 3.19 3.19 HS.526723 0.39 -0.21 2.98 -0.20 -0.03 1 2 3 4 5 3.19 3.19 THSD3 -1.04 -0.29 2.89 0.47 -0.69 1 2 3 4 5 3.18 3.18 HS.539566 0.54 -0.69 2.49 0.51 -0.49 1 2 3 4 5 3.18 3.18 PLA2G2F -1.37 1.49 4.66 0.03 0.16 1 2 3 4 5 3.17 3.17 DAPL1 -0.71 -0.90 2.27 -1.57 0.12 1 2 3 4 5 3.17 3.17 LEMD1 1.28 -1.43 1.74 6.26 2.86 1 2 3 4 5 3.17 3.17 NACA2 0.37 -0.19 2.98 1.81 -0.26 1 2 3 4 5 3.17 3.17 LOC643927 -1.42 -0.88 2.28 0.17 -2.03 1 2 3 4 5 3.16 3.16 ADRBK1 0.91 -1.55 1.61 -0.46 -0.29 1 2 3 4 5 3.16 3.16 HS.130964 -0.61 -0.86 2.30 1.91 -0.42 1 2 3 4 5 3.16 3.16 HS.572622 3.73 3.22 6.38 2.07 0.53 1 2 3 4 5 3.16 3.16 HS.578142 -0.48 0.35 3.50 0.80 -0.30 1 2 3 4 5 3.15 3.15 HS.528174 3.32 0.71 3.86 1.20 -0.47 1 2 3 4 3.15 3.15 C160RF78 0.38 1.00 4.14 -0.38 3.47 1 2 3 4 5 3.14 3.14 Table 3 51 HS.171251 2.99 0.26 3.40 -0.04 1.81 1 2 3 4 5 3.14 3.14 HS.582694 1.16 -0.14 3.00 -0.57 -0.20 1 2 3 4 5 3.14 3.14 LOC126075 -0.19 -0.12 3.02 -0.09 2.24 1 2 3 4 5 3.14 3.14 LOC653145 -0.36 0.20 3.34 1.49 -0.23 1 2 3 4 5 3.14 3.14 LCE3C -0.59 -0.63 2.50 -0.38 0.07 1 2 3 4 5 3.13 3.13 RHCG 0.43 -0.55 2.58 -0.29 0.61 1 2 3 4 5 3.13 3.13 TAS2R16 -0.69 -0.13 3.00 -0.51 3.13 1 2 3 4 5 3.13 3.13 HS.562162 -0.74 -0.31 2.82 0.81 0.30 1 2 3 4 5 3.13 3.13 FOXA2 -0.47 -3.40 -0.28 -1.79 2.66 1 2 3 4 5 3.12 3.12 HS.441581 0.36 -0.14 2.98 1.34 0.24 1 2 3 4 5 3.12 3.12 HS.539137 -0.21 -0.05 3.07 -0.75 0.26 1 2 3 4 5 3.12 3.12 NR4A1 3.51 -0.67 2.45 -0.50 -0.01 1 2 3 4 5 3.12 3.12 OR2M1P -0.60 -0.21 2.89 2.06 0.27 1 2 3 4 5 3.11 3.11 HS.444684 1.34 -0.92 2.19 -0.37 1.32 1 2 3 4 5 3.11 3.11 ZIM2 -0.09 -0.16 2.95 -0.76 0.45 1 2 3 4 5 3.11 3.11 HS.564235 0.35 0.36 3.46 -0.85 -0.26 1 2 3 4 5 3.10 3.10 HS.8429 0.23 1.47 4.58 1.80 -0.33 1 2 3 4 5 3.10 3.10 OR6B1 -0.39 -1.20 1.90 0.62 1.11 1 2 3 4 5 3.10 3.10 TAS2R40 -0.54 -1.25 1.85 -0.59 -1.50 1 2 3 4 5 3.10 3.10 BC02 -1.25 -1.40 1.69 -0.98 0.89 1 2 3 4 5 3.09 3.09 HS.170296 -0.27 -0.74 2.34 0.13 -0.52 1 2 3 4 5 3.08 3.08 LOC442726 1.82 -0.83 2.24 -0.82 7.21 1 2 3 4 5 3.08 3.08 SOX9 2.08 -1.02 2.05 0.09 -0.06 1 2 3 4 5 3.08 3.08 HS.521636 -0.93 -1.37 1.71 0.64 -0.75 1 2 3 4 5 3.07 3.07 HS.496952 2.28 -0.10 2.97 -0.02 -0.65 1 2 3 4 5 3.07 3.07 TREH -0.16 -0.24 2.82 0.65 -0.41 1 2 3 4 5 3.06 3.06 CA12 3.59 -1.00 2.06 0.38 1.26 1 2 3 4 5 3.06 3.06 HS.564513 0.00 -0.03 3.03 0.84 -0.35 1 2 3 4 5 3.06 3.06 HS.561980 -0.53 0.20 3.26 0.01 -0.57 1 2 3 4 5 3.06 3.06 C100RF114 -0.74 -0.72 2.33 -0.70 0.89 1 2 3 4 5 3.06 3.06 P2RXL1 -0.37 -0.35 2.70 -0.43 0.89 1 2 3 4 5 3.06 3.06 WISP1 -0.52 -1.54 1.51 -0.97 -0.55 1 2 3 4 5 3.05 3.05 HS.543400 2.38 -0.01 3.05 0.19 0.52 1 2 3 4 5 3.05 3.05 HS.559248 -1.20 -1.49 1.56 4.43 1.12 1 2 3 4 5 3.05 3.05 DI01 3.11 -0.14 2.91 0.93 -1.68 1 2 3 4 5 3.05 3.05 HS.539658 0.52 -0.73 2.31 2.88 -1.01 1 2 3 4 5 3.05 3.05 HS.98692 0.88 -0.56 2.48 -0.62 -0.15 1 2 3 4 5 3.04 3.04 LOC649652 -0.21 -0.65 2.39 0.42 0.76 1 2 3 4 5 3.04 3.04 LOC647439 -0.19 -0.25 2.80 -0.34 -0.38 1 2 3 4 5 3.04 3.04 HS.554691 0.02 2.70 5.74 0.20 0.88 1 2 3 4 5 3.04 3.04 LOC643722 -0.39 -0.83 2.20 -0.57 0.08 1 2 3 4 5 3.04 3.04 LOC441709 0.17 1.67 4.71 -0.80 -0.62 1 2 3 4 5 3.04 3.04 SERPINA5 0.47 -0.84 2.19 -0.83 0.75 1 2 3 4 5 3.03 3.03 RELN 0.37 -0.23 2.80 -0.02 -0.22 1 2 3 4 5 3.03 3.03 C10RF126 -0.50 -0.46 2.57 0.24 -0.02 1 2 3 4 5 3.03 3.03 HS.434128 1.74 -0.72 2.30 -1.76 -0.95 1 2 3 4 5 3.02 3.02 LOC652879 -0.63 -1.46 1.57 -0.84 0.06 1 2 3 4 5 3.02 3.02 LOC650268 -0.06 -0.31 2.71 0.12 -0.40 1 2 3 4 5 3.02 3.02 HS.559742 -0.85 -1.79 1.23 1.72 -1.53 1 2 3 4 5 3.02 3.02 Table 3 52

HS.563215 -0.90 0.09 3.11 -0.05 -0.27 1 2 3 4 5 3.02 3.02 MYBPC2 0.03 -1.00 2.01 1.65 -0.46 1 2 3 4 5 3.01 3.01 A3GALT2 -1.66 -0.82 2.19 1.16 0.20 1 2 3 4 5 3.01 3.01 HS.565653 -0.67 -0.90 2.11 3.26 -0.56 1 2 3 4 5 3.00 3.00 HS.552199 1.26 -0.25 2.75 1.95 0.11 1 2 3 4 5 3.00 3.00 KCNJ6 -0.90 -0.97 2.03 2.59 -0.73 1 2 3 4 5 3.00 3.00 HS.98186 -0.38 -0.62 2.38 1.95 0.05 1 2 3 4 5 3.00 3.00 LOC731158 0.73 -0.84 2.15 -0.02 -0.76 1 2 3 4 5 2.99 2.99 PNLDC1 1.17 -1.01 1.98 -0.76 1.53 1 2 3 4 5 2.99 2.99 LOC651177 0.02 -0.52 2.47 1.31 0.67 1 2 3 4 5 2.99 2.99 LOC651208 -0.89 -0.42 2.56 -0.51 -0.21 1 2 3 4 5 2.98 2.98 HS.562423 1.88 -0.09 2.89 -0.42 0.04 1 2 3 4 5 2.98 2.98 HS.563998 0.57 -0.09 2.89 2.45 4.26 1 2 3 4 5 2.98 2.98 KRTAP5-3 -1.33 -0.95 2.03 0.71 -0.68 1 2 3 4 5 2.97 2.97 HS.146732 2.33 -0.23 2.75 -0.75 -0.40 1 2 3 4 5 2.97 2.97 HS.211561 4.41 1.17 4.14 1.98 -0.40 1 2 3 4 5 2.97 2.97 TM6SF2 -0.64 -2.45 0.52 -0.57 2.30 1 2 3 4 5 2.97 2.97 LOC642785 0.81 0.17 3.14 1.26 2.04 1 2 3 4 5 2.97 2.97 HS.147231 -0.34 -1.36 1.60 -0.87 -0.75 1 2 3 4 5 2.96 2.96 0R7C1 0.51 -1.61 1.35 2.10 2.07 1 2 3 4 5 2.96 2.96 INHBE -0.69 -0.66 2.30 -0.37 -0.36 1 2 3 4 5 2.96 2.96 HS.566176 0.46; -1.54 1.42 -0.40 3.47 1 2 3 4 5 2.96 2.96 HS. 170939 -0.50 -0.30 2.66 -0.10 -0.18 1 2 3 4 5 2.95 2.95 LOC158730 0.45 -0.07 2.89 0.80 0.51 1 2 3 4 5 2.95 2.95 TMEM151 -0.44 ; -0.26 2.69 -0.17 -0.37 1 2 3 4 5 2.95 2.95 HS.534682 1.38 -0.53 2.42 -0.10 3.09 1 2 3 4 5 2.95 2.95 F13B -0.95 -1.75 1.21 -1.28 0.21 1 2 3 4 5 2.95 2.95 LOC339879 0.10 0.57 3.52 0.72 0.24 1 2 3 4 5 2.95 2.95 LOC646716 -0.08 -0.56 2.39 -0.16 -0.25 1 2 3 4 5 2.95 2.95 C90RF61 0.67 0.10 3.04 -0.49 1.21 1 2 3 4 5 2.94 2.94 HS.543729 2.95 1.17 4.11 0.25 -0.45 1 2 3 4 5 2.94 2.94 MMP16 0.02 -1.54 1.41 -1.50 3.37 1 2 3 4 5 2.94 2.94 LOC645294 0.84 -0.24 2.70 -0.18 1.51 1 2 3 4 5 2.94 2.94 OR12D3 0.95 -0.62 2.32 -0.41 -1.37 1 2 3 4 5 2.94 2.94 HS.564462 -0.87 0.41 3.34 2.54 -0.87 1 2 3 4 5 2.94 2.94 HS.486102 0.47 -0.10 2.83 0.83 -0.01 1 2 3 4 5 2.94 2.94 HS.545835 5.86 -0.83 2.10 -1.25 -0.07 1 2 3 4 5 2.93 2.93 HS. 148649 -0.41 -0.35 2.58 -0.59 -0.45 1 2 3 4 5 2.93 2.93 HS.578993 4.76 -0.63 2.29 0.26 0.42 1 2 3 4 5 2.93 2.93 HS.128113 -0.57 -1.11 1.81 -0.61 1.13 1 2 3 4 5 2.92 2.92 HS.565342 0.41 -1.51 1.41 0.04 1.03 1 2 3 4 5 2.92 2.92 GRIA4 -0.22 -1.46 1.46 -0.71 0.14 1 2 3 4 5 2.92 2.92 HS.55366 1.21 0.42 3.34 1.05 1.59 1 2 3 4 5 2.92 2.92 TMEM10 -1.29 -0.81 2.11 0.40 1.28 1 2 3 4 5 2.92 2.92 LOC646731 0.23 -0.43 2.48 0.44 2.55 1 2 3 4 2.92 2.92 LOC653527 1.05 -0.32 2.59 6.60 2.44 1 2 3 4 5 2.92 2.92 MAGEB4 -0.24 0.74 3.65 1.19 1.26 1 2 3 4 5 2.91 2.91 AQP5 -0.09 0.38 3.29 0.83 0.46 1 2 3 4 5 2.91 2.91 LOC652655 -0.75 0.07 2.97 -0.40 -0.22 1 2 3 4 5 2.91 2.91 Table 3 53 OR51I1 -0.09 1.08 3.98 1.12 -0.35 1 2 3 4 5 2.90 2.90 HS.307111 1.58 0.00 2.90 -0.05 0.04 1 2 3 4 5 2.90 2.90 HS.581376 -0.69 0.59 3.49 -0.06 1.36 1 2 3 4 5 2.90 2.90 XAGE5 -2.02 -2.58 0.31 2.43 -1.01 1 2 3 4 5 2.90 2.90 HS. 144030 0.90 0.53 3.42 -0.13 -0.17 1 2 3 4 5 2.89 2.89 HS.541682 0.00 -0.40 2.49 -0.26 0.55 1 2 3 4 5 2.89 2.89 DPYS 0.58 -0.73 2.15 -0.23 -0.09 1 2 3 4 5 2.88 2.88 PPY2 -0.24 -0.97 1.91 1.46 0.24 1 2 3 4 5 2.88 2.88 HS.426162 0.24 0.73 3.61 0.05 -0.59 1 2 3 4 5 2.88 2.88 THRSP 0.70 -2.82 0.06 -1.39 -0.50 1 2 3 4 5 2.87 2.87 CDX4 -0.79 -0.99 1.88 -0.58 0.89 1 2 3 4 5 2.87 2.87 LOC647035 -0.07 -0.34 2.54 -0.41 1.77 1 2 3 4 5 2.87 2.87 HS.562621 0.25 0.03 2.90 -0.33 -0.20 1 2 3 4 5 2.87 2.87 STEAP2 2.06 -0.68 2.19 1.26 1.23 1 2 3 4 5 2.87 2.87 HS.135696 0.11 -0.92 1.95 -0.72 1.37 1 2 3 4 5 2.87 2.87 HS.567138 0.53 -1.18 1.69 0.57 1.24 1 2 3 4 5 2.86 2.86 SPINT4 -0.70 -1.31 1.54 -0.63 3.37 1 2 3 4 5 2.86 2.86 LOC652844 1.69 -1.49 1.37 -0.49 -0.09 1 2 3 4 5 2.86 2.86 HS.559716 -0.15 -0.23 2.62 0.71 0.32 1 2 3 4 5 2.85 2.85 HS.539576 0.12 1.42 4.27 0.46 0.01 1 2 3 4 5 2.85 2.85 LOC730034 -0.55 0.25 3.10 1.25 -0.52 1 2 3 4 5 2.85 2.85 HS.564257 -0.34 -0.16 2.68 -0.21 0.25 1 2 3 4 5 2.85 2.85 HS.121413 0.08 -0.08 2.76 0.46 0.25 1 2 3 4 5 2.85 2.85 KRTAP8-1 1.53 -1.01 1.83 -0.60 -0.18 1 2 3 4 5 2.84 2.84 HS.471111 -0.20 0.10 2.93 0.78 -0.35 1 2 3 4 5 2.83 2.83 LOC650488 1.32 -1.27 1.55 1.14 0.00 1 2 3 4 5 2.83 2.83 UGT3A2 0.01 -1.64 1.19 0.09 2.17 1 2 3 4 5 2.83 2.83 LOC649305 -0.13 -0.12 2.70 0.09 -0.08 1 2 3 4 5 2.83 2.83 HS.147085 -0.03 -0.43 2.39 -0.13 1.15 1 2 3 4 5 2.82 2.82 CCDC114 -1.04 1.47 4.30 -0.39 -1.59 1 2 3 4 5 2.82 2.82 HS.542213 -0.30 -0.38 2.44 -0.04 -0.51 1 2 3 4 5 2.82 2.82 LPHN2 -0.32 -1.96 0.86 -0.67 -0.36 1 2 3 4 5 2.82 2.82 0R4N4 -0.98 -0.80 2.01 -0.41 -0.51 1 2 3 4 5 2.82 2.82 HS.546087 0.61 -0.67 2.14 -1.21 -0.23 1 2 3 4 5 2.81 2.81 HS.583531 -0.19 -0.26 2.55 0.22 1.56 1 2 3 4 5 2.81 2.81 LOC388910 -1.04 0.55 3.36 0.22 -0.83 1 2 3 4 5 2.81 2.81 OR3A2 1.06 -0.75 2.06 1.54 0.72 1 2 3 4 5 2.81 2.81 HS.563895 -0.37 -0.46 2.34 0.72 -0.08 1 2 3 4 5 2.80 2.80 STMN4 0.99 0.53 3.34 3.36 -0.94 1 2 3 4 5 2.80 2.80 HS.411472 -1.70 -0.58 2.22 4.21 0.88 1 2 3 4 5 2.80 2.80 HS.574096 -0.23 0.06 2.86 0.75 -0.28 1 2 3 4 5 2.80 2.80 LDHAL6B -0.56 0.57 3.37 2.32 0.42 1 2 3 4 5 2.80 2.80 HS.547058 -0.40 -0.50 2.30 0.51 1.08 1 2 3 4 5 2.80 2.80 ATN4 3.62 -1.60 1.20 -0.03 1.61 1 2 3 4 5 2.80 2.80 RTDR1 -1.59 , -0.49 2.31 -0.04 -1.51 1 2 3 4 5 2.80 2.80 HS.150163 -0.40 0.28 3.07 -0.39 -0.18 1 2 3 4 5 2.80 2.80 HS.563056 0.55 -0.30 2.49 -0.87 3.10 1 2 3 4 5 2.79 2.79 LOC729967 0.32 -0.19 2.60 -0.62 -0.31 1 2 3 4 5 2.79 2.79 HS.310427 -0.41 0.30 3.09 -0.91 -0.27 1 2 3 4 5 2.79 2.79 Table 3 54

HS.577776 -0.06 0.78 3.57 1.00 3.15 1 2 3 4 5 2.79 2.79 GOT1L1 0.80 -0.52 2.26 4.73 0.10 1 2 3 4 5 2.79 2.79 CYP4A22 4.00 -0.29 2.50 2.42 1.15 1 2 3 4 5 2.79 2.79 FCN2 -0.58 -0.98 1.80 -0.70 -0.54 1 2 3 4 5 2.79 2.79 LOC648473 1.15 0.16 2.94 -1.30 -0.19 1 2 3 4 5 2.79 2.79 FOXP3 -0.61 -0.51 2.27 2.14 -0.65 1 2 3 4 5 2.78 2.78 HS.134230 -0.45 -1.12 1.65 0.37 0.42 1 2 3 4 5 2.77 2.77 C150RF2 0.29 -0.69 2.09 0.14 -0.38 1 2 3 4 5 2.77 2.77 ZCCHC13 0.75 1.95 4.72 -0.07 -0.32 1 2 3 4 5 2.77 2.77 LOC651701 0.71 -0.44 2.33 1.00 0.12 1 2 3 4 5 2.77 2.77 LOC651794 0.02 -0.71 2.06 1.62 1.10 1 2 3 4 5 2.77 2.77 BTG4 0.91 -0.43 2.33 -0.31 -0.98 1 2 3 4 5 2.76 2.76 C170RF78 -0.68 -0.91 1.84 -0.30 0.03 1 2 3 4 5 2.75 2.75 FLG2 0.85 -0.61 2.14 0.90 0.12 1 2 3 4 5 2.75 2.75 ATP1A2 0.67 -1.98 0.77 -0.52 2.54 1 2 3 4 5 2.75 2.75 HS.563920 1.54 -0.65 2.10 -0.73 0.44 1 2 3 4 5 2.75 2.75 WNT8A 1.06 -0.96 1.79 0.84 1.37 1 2 3 4 5 2.75 2.75 WDR78 -0.36 -0.58 2.16 1.16 -0.90 1 2 3 4 5 2.75 2.75 HS.130130 -0.21 -0.52 2.22 -0.04 -0.27 1 2 3 4 5 2.75 2.75 LOC652625 -0.45 0.35 3.10 -0.10 -0.61 1 2 3 4 5 2.74 2.74 LOC642808 -0.85 -0.39 2.36 0.75 -0.17 1 2 3 4 5 2.74 2.74 KCNA4 -0.77 -1.53 1.21 -1.76 1.16 1 2 3 4 5 2.74 2.74 HS.145174 -0.77 -0.61 2.13 -0.23 0.02 1 2 3 4 5 2.74 2.74 HS.540761 -0.45 -1.13 1.62 -1.09 -0.39 1 2 3 4 5 2.74 2.74 ESC02 0.57 -0.99 1.75 4.73 -0.08 1 2 3 4 5 2.74 2.74 LOC401387 0.03 0.18 2.91 -1.04 -0.43 1 2 3 4 5 2.74 2.74 CACNA1A -0.44 0.73 3.46 -0.35 2.29 1 2 3 4 5 2.73 2.73 HS.541989 3.16 0.67 3.41 0.80 1.63 1 2 3 4 5 2.73 2.73 HS.312050 -0.02 -0.91 1.82 0.54 1.78 1 2 3 4 5 2.73 2.73 HS.583940 -0.27 -0.75 1.98 -0.63 -0.65 1 2 3 4 5 2.73 2.73 LOC645468 -0.26 0.27 3.00 1.86 0.26 1 2 3 4 5 2.73 2.73 AHRR 1.42 -0.35 2.37 -0.20 -0.46 1 2 3 4 5 2.72 2.72 HS.573902 0.92 -0.71 2.01 0.30 -0.16 1 2 3 4 5 2.72 2.72 C120RF53 -0.48 -1.21 1.51 0.38 -1.16 1 2 3 4 5 2.72 2.72 RIT2 -0.63 0.41 3.13 4.91 1.88 1 2 3 4 5 2.72 2.72 LOC732316 -0.38 -0.12 2.60 0.07 1.01 1 2 3 4 5 2.72 2.72 LOC643037 0.50 -0.80 1.91 -0.40 -0.71 1 2 3 4 5 2.71 2.71 SSTR4 3.17 -0.74 1.97 -0.61 0.50 1 2 3 4 5 2.71 2.71 HS.564722 0.12 -0.73 1.97 -0.06 0.08 1 2 3 4 5 2.70 2.70 HS.542520 -0.55 -0.27 2.43 -0.53 0.02 1 2 3 4 5 2.70 2.70 HS.540557 6.24 0.22 2.92 0.59 -0.59 1 2 3 4 5 2.70 2.70 NLRP6 -0.77 -0.72 1.98 2.54 0.10 1 2 3 4 5 2.70 2.70 HS.544564 -0.68 -1.08 1.62 0.43 1.00 1 2 3 4 5 2.70 2.70 PCDHB2 1.49 0.38 3.08 1.98 0.14 1 2 3 4 5 2.70 2.70 HS.253412 -0.51 0.30 3.00 0.28 -0.63 1 2 3 4 5 2.70 2.70 GLRA2 -0.43 -1.06 1.64 1.76 3.42 1 2 3 4 5 2.70 2.70 HS.116120 -0.90 0.83 3.53 -0.14 -0.49 1 2 3 4 5 2.70 2.70 RNF151 0.77 -1.26 1.43 1.72 -0.47 1 2 3 4 5 2.69 2.69 HS.583757 -0.65 -0.27 2.42 -0.17 -0.59 1 2 3 4 5 2.69 2.69 Table 3 55 OSR1 -0.78 -1.73 0.96 -0.62 -1.11 1 2 3 4 5 2.69 2.69 HS.545041 1.71, -0.05 2.63 1.60 -0.33 1 2 3 4 5 2.69 2.69 KCNE4 2.34 -1.09 1.59 -0.04 -1.37 1 2 3 4 5 2.68 2.68 HS.537697 0.47 1.34 4.02 1.12 -0.96 1 2 3 4 5 2.68 2.68 HS.525315 -0.55 -0.13 2.55 -0.02 1.01 1 2 3 4 5 2.68 2.68 HS.576313 -0.27 -0.54 2.14 0.72 -0.21 1 2 3 4 5 2.68 2.68 LOC440277 -0.03 -0.72 1.95 -0.48 0.31 1 2 3 4 5 2.67 2.67 HS.576809 0.90 0.37 3.04 0.52 2.80 1 2 3 4 5 2.67 2.67 PCDHB8 -0.22 -0.73 1.94 0.69 0.61 1 2 3 4 5 2.67 2.67 HS.546132 1.35 -0.34 2.33 -0.38 3.80 1 2 3 4 5 2.66 2.66 LOC728340 3.89 -0.59 2.08 2.84 -0.21 1 2 3 4 5 2.66 2.66 DEFB124 -0.62 -0.65 2.01 -0.54 -0.14 1 2 3 4 5 2.66 2.66 BAI2 0.38 -1.23 1.44 -1.47 -0.90 1 2 3 4 5 2.66 2.66 HS.161223 -0.02 -0.11 2.55 1.04 1.84 1 2 3 4 5 2.66 2.66 FSTL5 -1.31 0.76 3.42 1.05 2.57 1 2 3 4 5 2.66 2.66 ANGPTL5 0.92 -0.58 2.08 0.82 -1.15 1 2 3 4 5 2.66 2.66 HS.564879 0.25 -0.07 2.58 0.84 -0.32 1 2 3 4 5 2.66 2.66 HS.538035 -0.31 -1.91 0.74 -0.23 2.20 1 2 3 4 5 2.65 2.65 HS.562372 0.29 -0.84 1.81 0.66 1.15 1 2 3 4 5 2.65 2.65 PGF 0.75 -1.24 1.41 6.15 -0.46 1 2 3 4 2.65 2.65 HS.569047 0.57 -0.83 1.81 -0.49 0.98 1 2 3 4 5 2.65 2.65 LOC647656 1.54 -0.61 2.04 2.26 -1.09 1 2 3 4 5 2.65 2.65 SGCZ 4.36 0.32 2.97 -0.45 0.12 1 2 3 4 5 2.64 2.64 HS.85968 0.73 2.72 5.37 1.14 0.60 1 2 3 4 5 2.64 2.64 HS.521416 -0.37 -0.31 2.33 -0.37 1.11 1 2 3 4 5 2.64 2.64 KRTAP9-3 -0.98 -1.00 1.64 0.69 0.23 1 2 3 4 5 2.64 2.64 FU32154 -0.32 0.83 3.46 0.44 2.59 1 2 3 4 5 2.63 2.63 OLFM2 0.01 -1.33 1.30 -0.81 -0.65 1 2 3 4 5 2.63 2.63 PAP2D 1.64 -1.06 1.57 -0.62 0.29 1 2 3 4 5 2.63 2.63 HS.562408 0.28 -0.39 2.24 -0.81 -0.26 1 2 3 4 5 2.63 2.63 HS.577361 -0.03 -0.14 2.49 -0.08 0.11 1 2 3 4 5 2.63 2.63 HS.197076 -0.54 -0.81 1.81 0.47 -0.52 1 2 3 4 2.62 2.62 PDE6C 0.31 -0.81 1.81 5.93 3.59 1 2 3 4 5 2.62 2.62 MYT1L 2.34 0.21 2.83 0.41 -0.18 1 2 3 4 5 2.62 2.62 HS.565058 2.00 -1.51 1.10 -0.73 -0.78 1 2 3 4 5 2.61 2.61 PCDHGA1 -0.21 -0.14 2.47 -0.41 -0.34 1 2 3 4 5 2.61 2.61 LOC644704 0.29 -0.99 1.61 -0.59 -1.22 1 2 3 4 5 2.60 2.60 HS.564090 -0.44 -0.10 2.50 0.16 0.60 1 2 3 4 5 2.60 2.60 LOC731085 0.66 -0.40 2.21 -0.29 -1.15 1 2 3 4 5 2.60 2.60 LOC648691 0.07 0.23 2.83 1.26 0.71 1 2 3 4 5 2.60 2.60 OR6M1 -0.48 1.09 3.69 -0.69 0.46 1 2 3 4 5 2.60 2.60 LOC652077 1.46 -1.44 1.16 -0.54 -0.75 1 2 3 4 5 2.60 2.60 NPFFR2 -0.85 -0.83 1.77 -0.16 0.88 1 2 3 4 5 2.60 2.60 TM4SF5 -0.90 -0.82 1.78 0.20 1.47 1 2 3 4 5 2.60 2.60 MYBPC1 -0.61 -0.28 2.32 0.15 1.11 1 2 3 4 5 , 2.59 2.59 GAL -0.48 -1.20 1.39 1.86 -1.32 1 2 3 4 5 ; 2.59 2.59 HS.432947 -0.11 -1.03 1.57 0.81 1.95 1 2 3 4 5 2.59 2.59 DEFB104A -0.34 -0.04 2.55 -0.36 -0.13 1 2 3 4 5 2.59 2.59 LOC340069 3.36 2.81 5.40 0.76 -0.85 1 2 3 4 5 2.59 2.59 Table 3 56 HS.538149 0.82 -0.18 2.41 1.22 1.50 1 2 3 4 5 2.59 2.59 HS.566000 0.82 -0.87 1.72 0.39 2.12 1 2 3 4 5 2.59 2.59 OR6C3 -0.06 1.46 4.05 0.09 -0.07 1 2 3 4 5 2.58 2.58 HS.548777 -0.90 -0.44 2.14 0.32 3.92 1 2 3 4 5 2.58 2.58 HS.36034 0.51 -0.43 2.15 -0.85 -0.13 1 2 3 4 5 2.58 2.58 HS.570912 4.94 -0.48 2.10 -0.32 0.33 1 2 3 4 5 2.58 2.58 HS.380243 -0.51 0.24 2.81 -0.70 -0.14 1 2 3 4 5 2.58 2.58 PPYR1 1.44 -1.06 1.52 -0.26 1.09 1 2 3 4 5 2.58 2.58 HS.208717 0.16 -0.77 1.81 -0.36 -0.47 1 2 3 4 2.58 2.58 LOC642578 -0.19 -0.38 2.19 0.44 0.06 1 2 3 4 5 2.57 2.57 REGL . -0.40 -1.14 1.44 0.74 0.45 1 2 3 4 5 2.57 2.57 LOC283755 2.20 -1.15 1.42 -1.04 1.48 1 2 3 4 5 2.57 2.57 LOC439965 1.29 -0.17 2.40 1.60 0.07 1 2 3 4 5 2.57 2.57 SETD7 -0.71 -0.43 2.14 -0.43 -0.18 1 2 3 4 5 2.57 2.57 PDIA2 0.05 0.09 2.66 2.29 -1.06 1 2 3 4 5 2.57 2.57 HS.195363 -1.02 0.28 2.85 0.06 -0.36 1 2 3 4 5 2.57 2.57 HS.576396 -0.43 -1.23 1.34 -0.86 0.16 1 2 3 4 5 2.57 2.57 MC3R -0.75 0.21 2.78 1.60 -0.09 1 2 3 4 5 2.57 2.57 HS.352531 0.71 0.00 2.57 0.51 0.42 1 2 3 4 5 2.57 2.57 HS.213049 -0.92 -0.24 2.33 -0.11 0.02 1 2 3 4 5 2.57 2.57 HS.195400 -0.21 -0.02 2.55 0.51 -0.05 1 2 3 4 5 2.57 2.57 PCSK1 -0.78 -0.94 1.63 -0.37 -0.26 1 2 3 4 5 2.57 2.57 HS.539814 1.60 -0.57 2.00 4.83 -0.88 1 2 3 4 5 2.56 2.56 OR13C5 0.85 -0.96 1.61 3.36 2.09 1 2 3 4 5 2.56 2.56 IL31 1.03 1.54 4.10 -1.24 -1.22 1 2 3 4 5 2.56 2.56 HS.553410 -0.12 ; 0.10 2.66 0.91 1.29 1 2 3 4 5 2.56 2.56 HS.568073 -0.80 0.01 2.57 0.61 0.13 1 2 3 4 5 2.56 2.56 MGC23985 2.30 -0.87 1.69 1.44 -1.05 1 2 3 4 5 2.56 2.56 HS.584186 -1.09 ; -1.25 1.31 -1.83 0.42 1 2 3 4 5 2.55 2.55 SYT10 4.51 0.05 2.60 -2.51 0.79 1 2 3 4 5 2.55 2.55 HS.334221 . 0.20 -0.21 2.34 -0.45 1.34 1 2 3 4 5 2.55 2.55 HS.542606 0.74 -0.25 2.30 0.05 0.23 1 2 3 4 5 2.55 2.55 XDH -0.78 -1.84 0.72 -0.85 -1.13 1 2 3 4 5 2.55 2.55 LOC652094 -0.10 0.05 2.60 -0.57 -0.93 1 2 3 4 5 2.55 2.55 HS.545334 1.03 -0.22 2.33 -0.08 1.06 1 2 3 4 5 2.55 2.55 C60RF156 1.79 -1.53 1.02 0.52 -1.43 1 2 3 4 5 2.55 2.55 HS.562668 1.51 0.75 3.29 -0.72 -0.77 1 2 3 4 5 2.54 2.54 HS.543456 0.64 1.11 3.66 0.49 2.25 1 2 3 4 5 2.54 2.54 HS.584342 0.70 -1.11 1.43 2.04 0.41 1 2 3 4 5 2.54 2.54 PRB4 0.59 0.88 3.42 0.84 -0.54 1 2 3 4 5 2.54 2.54 HS.388031 -1.86 0.55 3.08 -1.04 -0.89 1 2 3 4 2.54 2.54 HS.542492 -0.99 0.83 3.36 -0.09 Ό .88 1 2 3 4 5 2.53 2.53 SPANXA1 0.32 -0.70 1.84 -0.38 -0.27 1 2 3 4 5 2.53 2.53 HS.208618 6.52 -1.07 1.46 1.28 -0.64 1 2 3 4 5 2.53 2.53 MAST1 0.29 -1.23 1.30 -0.78 -0.59 1 2 3 4 5 2.53 2.53 HS.249882 1.71 -1.14 1.38 -0.71 -1.15 1 2 3 4 5 2.53 2.53 HS.561037 -0.51 -0.14 2.38 -0.37 0.80 1 2 3 4 5 2.53 2.53 LOC653669 0.71 0.14 2.66 -0.07 1.79 1 2 3 4 5 2.52 2.52 LOC642000 2.49 -1.84 0.68 0.57 1.20 1 2 3 4 5 2.52 2.52 Table 3 57 HS.583727 -0.26 -0.96 1.56 -0.40 -0.31 1 2 3 4 5 2.52 2.52 LY6D -0.75 -0.61 1.91 0.19 -0.08 1 2 3 4 2.52 2.52 LOC651390 -0.44 -0.12 2.40 -0.25 -0.16 1 2 3 4 2.52 2.52 ZYG11A -0.76 -0.80 1.72 0.31 1.10 1 2 3 4 5 2.51 2.51 HS.437705 3.91 -0.70 1.81 0.58 2.17 1 2 3 4 5 2.51 2.51 LOC647283 5.36 1.32 3.83 1.85 -0.30 1 2 3 4 5 2.51 2.51 WFDC13 -0.95 -1.20 1.30 -1.11 1.30 1 2 3 4 5 2.51 2.51 LOC653801 -1.37 1.49 4.00 2.34 0.37 1 2 3 4 5 2.51 2.51 HS.334170 -0.20 -0.26 2.25 -0.23 0.24 1 2 3 4 5 2.51 2.51 COL1A1 0.08 -0.25 2.26 0.84 0.42 1 2 3 4 5 2.51 2.51 C10RF118 0.88 -1.27 1.23 0.50 3.90 1 2 3 4 2.51 2.51 HS.559836 -0.08 -0.53 1.97 -0.49 0.13 1 2 3 4 5 2.51 2.51 LOC652288 -0.77 -1.65 0.86 -1.72 0.67 1 2 3 4 5 2.51 2.51 HS.543222 -0.46 0.09 2.59 0.35 -0.05 1 2 3 4 5 2.50 2.50 HS.574391 -0.13 0.25 2.75 1.05 0.20 1 2 3 4 5 2.50 2.50 PPIC -0.32 1.57 4.07 3.73 5.19 1 2 3 4 5 2.50 2.50 DTX4 -0.24 -0.36 2.14 0.80 -0.31 1 2 3 4 5 2.50 2.50 HS.324547 1.84 0.44 2.94 -0.32 -0.21 1 2 3 4 5 2.50 2.50 C170RF77 -0.72 2.28 4.78 0.16 0.68 1 2 3 4 5 2.50 2.50 SOX3 -0.36 0.64 3.14 1.74 0.70 1 2 3 4 5 2.50 2.50 HFE -0.54 -0.85 1.65 -0.21 0.22 1 2 3 4 5 2.50 2.50 HS.580531 1.08 -0.09 2.40 0.21 -0.64 1 2 3 4 5 2.50 2.50 NEK5 -0.42 -1.08 1.42 -0.48 0.36 1 2 3 4 5 2.50 2.50 B4GALNT2 -0.56 0.20 2.69 0.79 2.89 1 2 3 4 2.49 2.49 PRODH -0.23 -1.65 0.84 -1.81 -0.62 1 2 3 4 2.49 2.49 LOC642153 -1.23 -0.85 1.64 0.66 3.09 1 2 3 4 5 2.49 2.49 HS.541708 -0.64 0.06 2.55 0.19 -0.24 1 2 3 4 5 2.49 2.49 HS.29235 0.55: -0.24 2.25 -0.39 -0.20 1 2 3 4 5 2.49 2.49 SNORD28 0.57 -0.97 1.52 -0.81 1.32 1 2 3 4 5 2.48 2.48 FAM20A 0.79 0.16 2.65 -0.33 1.50 1 2 3 4 5 2.48 2.48 HS.134215 0.62 -0.55 1.94 0.64 -0.44 1 2 3 4 5 2.48 2.48 KRTHB6 -0.25 -0.70 1.79 -0.79 0.83 1 2 3 4 5 2.48 2.48 HS.201755 2.82 -0.03 2.46 1.22 1.03 1 2 3 4 5 2.48 2.48 HS.540736 2.35 -0.52 1.96 2.08 0.16 1 2 3 4 5 2.48 2.48 LOC440361 4.22 -0.32 2.16 -0.33 -0.19 1 2 3 4 5 2.48 2.48 HS.207174 -0.07 -0.22 2.26 2.09 -0.45 1 2 3 4 5 2.48 2.48 TMEM56 2.28 0.20 2.68 1.81 -0.52 1 2 3 4 5 2.48 2.48 HS.199708 -0.39 -1.26 1.22 0.22 0.33 1 2 3 4 5 2.48 2.48 HS.538379 -0.41 -0.72 1.76 0.68 1.06 1 2 3 4 2.48 2.48 HS.544848 2.56 1.94 4.42 -0.01 3.15 1 2 3 4 5 2.47 2.47 LOC645689 3.53 -1.11 1.36 0.14 4.40 1 2 3 4 5 2.47 2.47 HS.572645 -0.14 -0.37 2.10 -0.27 0.04 1 2 3 4 5 2.47 2.47 HS.541723 1.26 0.87 3.34 1.36 -0.09 1 2 3 4 5 2.47 2.47 C140RF23 2.27 -0.84 1.63 0.68 1.11 1 2 3 4 5 2.47 2.47 HS.562855 2.10 -0.81 1.66 0.36 0.08 1 2 3 4 5 2.47 2.47 ANGPTL3 -0.77 0.14 2.61 1.24 0.38 1 2 3 4 5 2.47 2.47 HS.103334 -0.53 -0.71 1.76 0.36 2.48 1 2 3 4 5 2.47 2.47 C20ORF26 -0.28 0.29 2.75 0.30 1.89 1 2 3 4 5 2.47 2.47 MALAT1 -0.34 -0.33 2.13 0.52 1.64 1 2 3 4 5 2.46 2.46 Table 3 58 TNRC4 -0.72 -0.78 1.68 -1.10 -0.20 1 2 3 4 5 2.46 2.46 HS.408426 -0.56 0.05 2.51 -0.41 1.92 1 2 3 4 5 2.46 2.46 HS.494002 -0.36 -0.75 1.71 -0.67 0.62 1 2 3 4 5 2.46 2.46 VLDLR 0.19 -0.82 1.64 -0.26 -0.44 1 2 3 4 5 2.46 2.46 HS.571099 1.34 -0.49 1.96 -0.47 0.58 1 2 3 4 5 2.45 2.45 HS.561963 -0.16 -0.44 2.01 -0.53 0.15 1 2 3 4 5 2.45 2.45 0R8A1 -0.20 0.30 2.75 1.90 0.01 1 2 3 4 5 2.45 2.45 HS.538361 1.21 -0.36 2.08 -0.22 -0.15 1 2 3 4 5 2.45 2.45 HS.545712 0.59 0.06 2.51 -0.07 1.81 1 2 3 4 5 2.45 2.45 FU46257 7.96 -0.45 2.00 -0.98 -0.04 1 2 3 4 5 2.45 2.45 SLC1A6 -0.26 -1.16 1.28 0.11 0.01 1 2 3 4 5 2.45 2.45 CPB2 -0.65 -0.19 2.26 -0.92 1.84 1 2 3 4 5 2.45 2.45 AP0A5 5.21 -0.45 2.00 1.87 0.48 1 2 3 4 5 2.44 2.44 S0X5 0.86 0.05 2.49 -1.06 2.03 1 2 3 4 5 2.44 2.44 HS.126387 1.70 -1.16 1.28 1.38 -1.75 1 2 3 4 5 2.44 2.44 GPR61 0.25 -0.77 1.67 -0.02 -0.20 1 2 3 4 5 2.43 2.43 HS.560316 -0.41 0.44 2.87 1.68 -0.43 1 2 3 4 5 2.43 2.43 HS.224053 0.47 -0.24 2.19 0.20 1.05 1 2 3 4 5 2.43 2.43 GKN1 2.02 -0.37 2.06 -0.38 -0.54 1 2 3 4 5 2.43 2.43 HS.563164 -0.79 -0.49 1.94 -0.02 -0.22 1 2 3 4 5 2.43 2.43 C10ORF93 -0.78 -0.97 1.46 -1.23 2.06 1 2 3 4 5 2.43 2.43 G A D2 -1.29 -0.26 2.16 -0.98 2.50 1 2 3 4 5 2.42 2.42 HS.542885 2.70 0.52 2.94 0.05 -0.70 1 2 3 4 5 2.42 2.42 LOC653653 0.27 0.11 2.52 0.41 1.08 1 2 3 4 5 2.42 2.42 HS.565623 0.77 -0.17 2.24 1.11 0.85 1 2 3 4 5 2.42 2.42 AJAP1 -0.03 -0.33 2.08 0.11 -0.27 1 2 3 4 5 2.42 2.42 HS.567135 3.56 -2.02 0.40 -1.41 2.68 1 2 3 4 5 2.41 2.41 LOC653178 -0.32 -0.27 2.15 -0.36 -0.18 1 2 3 4 5 2.41 2.41 HS.565451 2.38 -0.06 2.36 -0.47 -0.23 1 2 3 4 5 2.41 2.41 HS.538483 -0.60 -0.41 2.00 -0.70 0.78 1 2 3 4 5 2.41 2.41 HS.443967 1.59 -0.67 1.74 1.06 1.14 1 2 3 4 5 2.41 2.41 HS.543982 3.43 0.45 2.85 -0.06 -0.28 1 2 3 4 5 2.41 2.41 HS.540277 0.84 2.54 4.94 1.97 -0.78 1 2 3 4 5 2.41 2.41 LOC647200 0.14 -0.42 1.99 1.20 0.03 1 2 3 4 5 2.41 2.41 OR4E2 -0.31 -0.27 2.14 0.96 -0.23 1 2 3 4 5 2.41 2.41 C130RF31 0.00 0.04 2.44 0.69 -0.09 1 2 3 4 5 2.40 2.40 HS.250340 0.07 0.75 3.15 -0.03 0.46 1 2 3 4 5 2.40 2.40 KRTAP19-1 0.09 -0.39 2.01 -0.47 -0.16 1 2 3 4 5 2.40 2.40 CYP3A5 -0.06 0.25 2.65 -0.43 0.05 1 2 3 4 5 2.40 2.40 MYBPHL -1.54 -0.34 2.06 0.89 1.31 1 2 3 4 5 2.39 2.39 HS.436378 -0.64 2.53 4.93 0.01 0.73 1 2 3 4 5 2.39 2.39 HS.542769 0.34 -0.32 2.07 -0.31 0.14 1 2 3 4 5 2.39 2.39 LOC650716 1.26 0.16 2.55 0.03 -0.25 1 2 3 4 5 2.39 2.39 HS.253188 -0.64 -0.68 1.71 -0.11 -0.31 1 2 3 4 5 2.39 2.39 LOC340515 0.32 -0.34 2.04 0.53 -0.17 1 2 3 4 5 2.39 2.39 LOC646501 -0.80 0.32 2.71 0.21 1.61 1 2 3 4 5 2.39 2.39 HS.428005 -0.18 -0.67 1.72 0.34 0.01 1 2 3 4 5 2.39 2.39 ZNF665 -2.01 -1.17 1.21 -0.20 -1.07 1 2 3 4 5 2.38 2.38 LOC283432 0.04 0.26 2.64 0.48 1.10 1 2 3 4 5 2.38 2.38 Table 3 59 KIAA2022 -1.13 0.55 2.93 -0.36 -0.37 1 2 3 4 5 2.38 2.38 LOC389458 -0.18 -0.15 2.23 0.14 0.21 1 2 3 4 5 2.38 2.38 HS.22930 0.29 -1.34 1.04 -0.33 0.88 1 2 3 4 5 2.38 2.38 CRIM2 -0.93 -0.37 2.01 0.57 0.88 1 2 3 4 5 2.38 2.38 HS.236298 1.05 -0.16 2.21 -0.23 -0.18 1 2 3 4 5 2.37 2.37 HS.310643 0.48 -0.50 1.88 2.28 1.97 1 2 3 4 5 2.37 2.37 HS.557928 0.09 -0.29 2.09 0.21 0.07 1 2 3 4 5 2.37 2.37 FLG -1.73 1.11 3.48 -1.29 -1.56 1 2 3 4 5 2.37 2.37 HS.96914 0.27 -1.43 0.94 -0.59 -0.30 1 2 3 4 5 2.37 2.37 APOD -0.57 -1.86 0.51 -0.16 2.23 1 2 3 4 5 2.37 2.37 HS.560432 0.53 1.05 3.42 5.82 4.09 1 2 3 4 5 2.37 2.37 HS.538858 -0.87 0.48 2.85 -1.04 0.09 1 2 3 4 5 2.37 2.37 HS.582647 0.32 -0.75 1.61 2.61 1.20 1 2 3 4 5 2.37 2.37 HS.473149 0.94 0.28 2.65 -0.44 0.12 1 2 3 4 5 2.37 2.37 LOC440386 1.09 -0.21 2.15 -0.13 0.64 1 2 3 4 5 2.37 2.37 LOC122038 0.13 -0.67 1.70 -0.31 -0.27 1 2 3 4 5 2.37 2.37 CHRDL2 -0.46 -0.98 1.38 0.72 1.14 1 2 3 4 5 2.36 2.36 TIM 50 -0.60 0.25 2.61 0.83 -0.15 1 2 3 4 5 2.36 2.36 HS.569266 0.10 0.16 2.52 0.88 -0.48 1 2 3 4 5 2.36 2.36 OR4Q3 -0.77 -0.82 1.53 -0.68 0.83 1 2 3 4 5 2.36 2.36 HS.543493 1.82 -1.91 0.44 0.06 -1.59 1 2 3 4 5 2.36 2.36 ANKRD56 -0.31 2.02 4.37 1.95 0.38 1 2 3 4 5 2.35 2.35 HS.113577 1.16 -2.13 0.22 0.86 0.78 1 2 3 4 5 2.35 2.35 LOC652183 -0.68 -0.85 1.50 0.48 2.66 1 2 3 4 5 2.35 2.35 MS4A5 -0.61 -1.11 1.24 1.31 0.47 1 2 3 4 5 2.35 2.35 ZP2 0.08 0.24 2.59 -1.28 -0.94 1 2 3 4 5 2.35 2.35 HS.566705 -0.57 0.04 2.39 -0.01 0.10 1 2 3 4 5 2.34 2.34 NTS 0.46 0.27 2.61 3.08 -0.42 1 2 3 4 5 2.34 2.34 HS.565035 -0.37 0.01 2.35 -0.32 0.63 1 2 3 4 5 2.34 2.34 TTC29 -0.50 -0.49 1.85 0.35 2.18 1 2 3 4 5 2.34 2.34 TUBA4 1.74 -1.07 1.27 2.03 -0.72 1 2 3 4 5 2.34 2.34 HS.520854 2.16 -0.73 1.61 -0.79 -0.58 1 2 3 4 5 2.34 2.34 HS.127990 -0.23 -0.34 1.99 -0.26 -0.10 1 2 3 4 5 2.34 2.34 MLANA -0.61 0.88 3.21 2.42 1.90 1 2 3 4 5 2.33 2.33 SIRT3 -0.48 -0.68 1.65 -0.40 -0.37 1 2 3 4 5 2.33 2.33 LOC652086 0.28 -0.71 1.62 0.45 -0.11 1 2 3 4 5 2.33 2.33 LOC647149 1.72 -0.96 1.37 -1.05 -0.87 1 2 3 4 5 2.33 2.33 HS.566158 -0.93 -1.09 1.24 1.14 -0.38 1 2 3 4 5 2.33 2.33 OR51B6 -0.65 -1.76 0.57 1.87 3.76 1 2 3 4 5 2.33 2.33 HS.156973 -0.30 -0.29 2.03 1.19 -0.63 1 2 3 4 5 2.33 2.33 HS.544468 1.91 -0.23 2.09 4.00 0.61 1 2 3 4 5 2.32 2.32 LOC646947 1.68 -0.41 1.92 2.60 0.51 1 2 3 4 5 2.32 2.32 HS. 140667 0.36 -0.29 2.03 2.60 0.23 1 2 3 4 5 2.32 2.32 GPR112 1.78 0.15 2.47 1.38 0.29 1 2 3 4 5 2.32 2.32 SNIP -0.96 -2.93 -0.61 -2.01 5.38 1 2 3 4 5 2.32 2.32 AP1S3 -0.73 -0.89 1.44 0.87 0.94 1 2 3 4 5 2.32 2.32 LOC400723 1.89 0.39 2.71 1.48 2.05 1 2 3 4 5 2.32 2.32 HS.352814 1.16 -0.34 1.98 -0.76 -0.31 1 2 3 4 5 2.32 2.32 AVPR1A 0.21 -0.12 2.19 0.00 2.62 1 2 3 4 5 2.32 2.32 Table 3 60 HS.566395 -0.28 -0.19 2.12 -0.36 -0.24 1 2 3 4 5 2.31 2.31 HS.544791 0.46 0.10 2.41 -0.47 -0.64 1 2 3 4 5 2.31 2.31 HS.542634 0.79 -0.93 1.38 0.77 -0.29 1 2 3 4 5 2.31 2.31 RBMY1B -1.01 -0.54 1.76 0.80 2.41 1 2 3 4 5 2.31 2.31 HS.153718 2.13 -0.89 1.41 1.34 -0.47 1 2 3 4 5 2.31 2.31 FAM90A11P 0.93 -0.68 1.63 2.13 -0.58 1 2 3 4 5 2.31 2.31 LOC653313 0.37 0.24 2.54 -0.37 1.41 1 2 3 4 5 2.31 2.31 LOC644897 -0.69 -0.96 1.34 1.26 -0.12 1 2 3 4 5 2.31 2.31 GAL3ST1 -0.37 -0.58 1.73 -0.01 0.62 1 2 3 4 5 2.31 2.31 ITIH5L 1.24 -1.20 1.11 -0.04 -0.66 1 2 3 4 5 2.31 2.31 CYP11B1 -0.76 -0.79 1.52 0.50 0.98 1 2 3 4 5 2.30 2.30 HS.580230 -0.20 -0.58 1.72 -0.94 -0.36 1 2 3 4 5 2.30 2.30 LOC729569 0.19 -0.49 1.82 1.25 -0.54 1 2 3 4 5 2.30 2.30 LOC644288 1.22 -1.29 1.02 3.90 0.01 1 2 3 4 5 2.30 2.30 LOC652404 -0.47 -0.36 1.94 0.43 -0.72 1 2 3 4 5 2.30 2.30 HS.580636 1.00 -0.46 1.84 1.03 1.83 1 2 3 4 5 2.30 2.30 MUM1L1 0.15 0.60 2.90 -0.41 -0.20 1 2 3 4 5 2.30 2.30 LOC650684 -0.64 -1.24 1.06 -0.33 1.14 1 2 3 4 5 2.30 2.30 HS.127550 -0.23 0.30 2.60 2.99 1.83 1 2 3 4 5 2.30 2.30 HS.570624 1.24 -0.79 1.51 3.04 4.90 1 2 3 4 5 2.30 2.30 LOC647370 -0.25 -0.43 1.87 -0.33 0.01 1 2 3 4 5 2.29 2.29 KIF4A -0.43, -1.37 0.93 -0.85 -0.58 1 2 3 4 5 2.29 2.29 FU35946 -1.49 -1.21 1.08 -0.61 1.90 1 2 3 4 5 2.29 2.29 HS.538000 -0.32 0.44 2.73 0.19 1.86 1 2 3 4 5 2.29 2.29 ZNF257 -0.03 -0.31 1.98 -0.95 0.16 1 2 3 4 5 ; 2.29 2.29 IL21 1.63 -0.38 1.90 3.99 -0.16 1 2 3 4 5 2.29 2.29 LOC648346 0.83 1.49 3.78 0.60 1.11 1 2 3 4 5 2.29 2.29 HS.563567 0.74 -0.15 2.14 0.47 0.58 1 2 3 4 5 2.29 2.29 LOC644554 4.02 -0.60 1.69 2.67 -0.35 1 2 3 4 5 2.28 2.28 LOC643311 -0.12 -1.14 1.14 2.91 0.09 1 2 3 4 5 2.28 2.28 CD164L2 3.02 0.72 3.00 -1.48 -1.27 1 2 3 4 5 2.28 2.28 FTCD -0.18 0.50 2.78 -0.09 0.13 1 2 3 4 5 2.28 2.28 HS.571652 1.13 -0.57 1.71 0.68 -0.91 1 2 3 4 5 2.28 2.28 SNX7 -0.79 -0.36 1.92 0.64 0.63 1 2 3 4 5 2.28 2.28 ANKRD30A -1.20 1.32 3.60 0.62 -0.16 1 2 3 4 5 2.28 2.28 HS.444244 -0.44 0.28 2.56 0.29 -0.25 1 2 3 4 5 2.28 2.28 HS.542804 1.92 -0.31 1.97 1.20 -1.26 1 2 3 4 5 2.28 2.28 LOC648217 -0.45 -1.24 1.04 -0.64 0.70 1 2 3 4 5 2.28 2.28 HS.543819 1.86 -0.10 2.18 1.02 0.73 1 2 3 4 5 2.28 2.28 HS.570524 -0.39 -0.06 2.22 2.12 2.34 1 2 3 4 5 2.28 2.28 LOC440030 0.09 -0.56 1.71 0.52 -0.07 1 2 3 4 5 2.27 2.27 HS.581175 -0.49 -0.82 1.45 1.50 -0.45 1 2 3 4 5 2.27' 2.27 HS.24321 1.34 -0.31 1.96 2.01 -0.40 1 2 3 4 5 2.27 2.27 FU46082 0.14 -0.30 1.96 -0.24 1.03 1 2 3 4 5 2.27 2.27 LOC652769 2.21 -0.10 2.17 -0.46 -1.16 1 2 3 4 5 2.27 2.27 C220RF31 -1.27 -1.76 0.50 1.71 -0.31 1 2 3 4 5 2.27 2.27 HS.582245 0.12 2.05 4.32 7.99 -0.28 1 2 3 4 5 2.26 2.26 HS.98838 -0.66 -1.11 1.15 -0.84 -0.59 1 2 3 4 5 2.26 2.26 HS.444133 -0.31 -0.27 2.00 -0.20 -0.14 1 2 3 4 5 2.26 2.26 Table 3 61 HS.439161 -0.46 -0.83 1.43 1.15 0.75 1 2 3 4 5 2.26 2.26 KCNV1 -0.61 -0.62 1.63 -1.07 -0.83 1 2 3 4 5 2.26 2.26 RNASE11 0.44 -0.23 2.02 0.13 -0.04 1 2 3 4 5 2.26 2.26 HS.574286 -0.25 -0.07 2.19 0.71 -0.38 1 2 3 4 5 2.26 2.26 RBM 0.95 -1.46 0.79 3.12 -0.25 1 2 3 4 5 2.25 2.25 HS.544671 0.37 0.01 2.26 0.62 0.00 1 2 3 4 5 2.25 2.25 HS.544464 -0.11 0.72 2.97 1.22 0.24 1 2 3 4 5 2.25 2.25 FU25770 4.80 -0.55 1.70 2.64 1.07 1 2 3 4 5 2.25 2.25 HS.26537 2.74 0.53 2.78 -1.44 0.05 1 2 3 4 5 ; 2.25 2.25 HS.579492 -0.71 -0.04 2.21 -0.03 1.07 1 2 3 4 5 2.25 2.25 LOC729396 0.54 0.31 2.56 2.14 1.09 1 2 3 4 5 2.25 2.25 NPY5R 0.71 -0.63 1.62 -0.25 -0.95 1 2 3 4 5 : 2.25 2.25 LOC651192 -0.03 -0.74 1.51 -0.05 3.18 1 2 3 4 5 2.24 2.24 HS.130626 0.85 -0.13 2.11 1.49 0.80 1 2 3 4 5 2.24 2.24 PCDHGA7 4.67 -2.67 -0.43 1.14 -1.09 1 2 3 4 5 2.24 2.24 CCDC38 -0.44 -0.60 1.64 -0.70 -0.76 1 2 3 4 5 2.24 2.24 HS.584425 0.25 -0.74 1.50 0.30 -0.30 1 2 3 4 5 2.24 2.24 HS.543663 0.14 0.95 3.19 0.09 0.10 1 2 3 4 5 2.24 2.24 VCY1B -0.81 -1.43 0.80 4.90 0.45 1 2 3 4 5 2.24 2.24 KRTAP19-3 0.80 -0.53 1.71 1.13 0.13 1 2 3 4 5 2.24 2.24 LOC642592 0.23 -0.13 2.11 1.60 0.15 1 2 3 4 5 2.24 2.24 FUT9 3.36 0.08 2.32 -1.83 0.31 1 2 3 4 5 2.24 2.24 KRT79 0.31 -0.15 2.08 -0.36 -0.43 1 2 3 4 5 2.24 2.24 HS.543964 -0.81 -1.47 0.76 -0.70 2.14 1 2 3 4 5 2.24 2.24 LOC651476 -0.18 -0.64 1.60 0.64 -1.17 1 2 3 4 5 2.24 2.24 NLGN4Y 0.68 -0.90 1.34 -0.61 0.47 1 2 3 4 5 ; 2.23 2.23 LOC645915 -0.24 -0.97 1.27 1.06 1.65 1 2 3 4 5 2.23 2.23 LOC136242 0.69 -0.42 1.81 0.07 -0.25 1 2 3 4 5 2.23 2.23 LCE3E 0.58 -0.70 1.52 -0.37 -0.55 1 2 3 4 5 2.22 2.22 LOC648629 0.05 -0.14 2.08 -0.70 0.41 1 2 3 4 5 2.22 2.22 CBLN2 -1.23 -1.28 0.94 0.21 0.66 1 2 3 4 5 2.22 2.22 HS.560007 0.98 -1.46 0.76 -0.54 0.97 1 2 3 4 5 2.22 2.22 HS.564590 1.90 2.44 4.66 -0.66 0.19 1 2 3 4 5 2.22 2.22 HS.131187 0.51 0.40 2.61 0.08 1.26 1 2 3 4 5 2.21 2.21 HS.476019 -0.88 0.04 2.25 0.55 -0.98 1 2 3 4 5 2.21 2.21 TCT 2 -0.51 -0.03 2.18 2.18 -0.87 1 2 3 4 5 2.21 2.21 HS.568556 1.49 -0.66 1.55 -0.59 0.29 1 2 3 4 5 2.21 2.21 HS.444370 0.44 -0.64 1.57 0.01 -0.61 1 2 3 4 5 2.21 2.21 HS.22469 0.13 -1.09 1.12 -0.59 -0.34 1 2 3 4 5 2.20 2.20 HS.560032 -0.21 -0.28 1.92 0.17 1.63 1 2 3 4 5 2.20 2.20 HS.565522 0.30 -0.33 1.88 -0.70 5.10 1 2 3 4 5 2.20 2.20 HS.568669 1.03 0.51 2.71 -0.44 -0.30- 1 2 3 4 5 2.20 2.20 R0B02 -0.73 -0.91 1.30 2.40 2.45 1 2 3 4 5 2.20 2.20 HS.542631 -0.62 0.35 2.55 -0.51 0.33 1 2 3 4 5 2.20 2.20 LOC441395 -0.29 -0.77 1.42 -0.67 0.06 1 2 3 4 5 2.20 2.20 C10ORF62 2.09 -1.28 0.92 -0.36 0.50 1 2 3 4 5 2.20 2.20 ISLR 0.16 -0.29 1.90 -0.41 -0.38 1 2 3 4 2.20 2.20 CST2 0.81 -1.74 0.46 -0.99 -0.56 1 2 3 4 5 2.20 2.20 HS.557851 -0.09 0.13 2.32 -0.17 -0.39 1 2 3 4 5 2.19 2.19 Table 3 62

LOC649944 -0.38 -0.57 1.63 0.42 4.74 1 2 3 4 5 2.19 2.19 DMBX1 1.36 -0.76 1.43 -0.75 -0.47 1 2 3 4 5 2.19 2.19 TAS2R7 -0.65 -0.94 1.25 -1.17 -1.56 1 2 3 4 5 2.19 2.19 OR10Z1 1.68 -0.28 1.91 0.96 1.03 1 2 3 4 5 2.19 2.19 KIRREL 0.18 0.12 2.31 1.71 1.56 1 2 3 4 5 2.19 2.19 CHDH 0.58 -0.51 1.67 -1.28 -0.63 1 2 3 4 5 2.19 2.19 LOC652554 1.99 -0.03 2.16 0.10 -0.01 1 2 3 4 5 2.19 2.19 HS.170957 4.70 1.43 3.62 0.81 -1.67 1 2 3 4 5 2.19 2.19 GAS2L2 -0.60 -0.47 1.72 0.00 -0.10 1 2 3 4 5 2.19 2.19 LOC649971 0.10 -0.54 1.65 -0.04 4.15 1 2 3 4 5 2.19 2.19 LOC643131 2.05 0.27 2.45 0.74 0.21 1 2 3 4 5 2.19 2.19 HS.513574 -0.71 -0.46 1.72 0.00 -0.53 1 2 3 4 5 2.18 2.18 HS.161330 1.33 -0.38 1.80 -0.07 -0.07 1 2 3 4 5 2.18 2.18 HS.210399 -0.22 -0.16 2.02 1.27 1.36 1 2 3 4 5 2.18 2.18 HS.569878 -0.39 0.22 2.40 0.49 1.01 1 2 3 4 5 2.18 2.18 HS.581035 -1.27 -1.55 0.63 2.13 0.11 1 2 3 4 5 2.18 2.18 HS.150043 0.48 -0.19 1.98 1.60 -0.22 1 2 3 4 5 2.18 2.18 TYR -0.32 -0.11 2.07 -0.31 0.26 1 2 3 4 5 2.18 2.18 HS.134028 0.06 -0.07 2.11 0.48 0.07 1 2 3 4 5 2.18 2.18 HS.561123 0.88 -0.99 1.18 -1.13 -0.05 1 2 3 4 5 2.17 2.17 DYRK3 0.06 0.43 2.60 0.57 -0.75 1 2 3 4 5 2.17 2.17 C10RF14 1.79 -0.36 1.82 -0.33 0.49 1 2 3 4 5 2.17 2.17 OR1K1 -0.57 -0.63 1.54 -0.70 0.84 1 2 3 4 5 2.17 2.17 HS.543925 0.31 -0.55 1.62 0.61 -0.71 1 2 3 4 5 2.17 2.17 LOC649896 -0.40 -1.32 0.85 1.71 0.13 1 2 3 4 2.17 2.17 OR52E2 0.59 -0.54 1.63 -0.91 -0.94 1 2 3 4 5 2.17 2.17 LOC646627 -0.85 -0.86 1.31 -1.13 -0.56 1 2 3 4 5 2.17 2.17 CALCR 0.81 -0.32 1.84 -0.76 -0.72 1 2 3 4 5 2.17 2.17 CLEC2A 1.43 0.30 2.46 0.00 0.47 1 2 3 4 5 2.17 2.17 HS.435075 1.19 2.92 5.08 8.35 0.24 1 2 3 4 5 2.16 2.16 HS.584252 -0.37 1.11 3.27 -1.02 -0.11 1 2 3 4 5 2.16 2.16 FU30430 -0.21 -0.25 1.91 -0.22 -0.28 1 2 3 4 5 2.16 2.16 TBC1D26 -0.53 0.16 2.32 0.44 2.80 1 2 3 4 5 2.16 2.16 MEOX2 2.08 0.42 2.58 0.88 -1.32 1 2 3 4 5 2.16 2.16 LOC648752 -0.16 -0.20 1.96 -0.13 0.07 1 2 3 4 5 2.16 2.16 HS.553270 0.58 -1.08 1.08 -0.09 -0.67 1 2 3 4 5 2.16 2.16 LOC389786 -0.11 -0.51 1.64 2.98 0.86 1 2 3 4 5 2.16 2.16 PHYHD1 -0.91 -1.07 1.09 0.38 2.48 1 2 3 4 5 2.15 2.15 C 4 R -0.01 -0.99 1.16 -0.89 -0.17 1 2 3 4 5 2.15 2.15 HS.290255 -0.61 1.57 3.72 3.23 1.58 1 2 3 4 5 2.15 2.15 GJA9 5.63 0.79 2.94 0.22 -0.06 1 2 3 4 5 2.15 2.15 HS.562513 4.88 -0.92 1.23 -0.27 1.67 1 2 3 4 5 2.15 2.15 ZNF440 2.58 -0.74 1.41 1.28 -0.04 1 2 3 4 5 2.14 2.14 LDLRAD1 -0.63 -0.31 1.84 -0.44 0.16 1 2 3 4 5 2.14 2.14 HS.130623 1.61 0.10 2.25 1.73 -0.31 1 2 3 4 5 2.14 2.14 OR2G6 2.38 -1.79 0.35 1.11 -0.04 1 2 3 4 5 2.14 2.14 HS.562176 -0.24 -0.10 2.04 -0.48 -0.62 1 2 3 4 5 2.14 2.14 HS.557083 0.49 -1.13 1.01 -0.22 -0.10 1 2 3 4 5 2.14 2.14 FLRT1 -0.50 -0.82 1.32 0.32 -0.15 1 2 3 4 5 2.14 2.14 Table 3 LOC647371 -0.53 -0.25 1.89 -0.52 -0.66 1 2 3 4 5 2.14 2.14 HS.550131 5.23 -1.17 0.97 0.65 2.31 1 2 3 4 5 2.14 2.14 BARHL1 -0.60 -0.83 1.31 -0.53 -1.07 1 2 3 4 5 2.14 2.14 HS.539748 -0.60 -0.41 1.73 0.04 0.80 1 2 3 4 5 2.14 2.14 DMRTC2 -0.46 -1.18 0.96 0.34 -1.49 1 2 3 4 5 2.14 2.14 C90RF122 -0.10 -1.07 1.07 -0.64 -0.46 1 2 3 4 5 2.14 2.14 HS.551363 -0.01 -0.03 2.10 -0.23 1.00 1 2 3 4 5 2.14 2.14 WNT7B 0.98 -0.50 1.64 0.12 4.73 1 2 3 4 5 2.14 2.14 HS.576136 -0.49 -0.78 1.36 0.45 -0.70 1 2 3 4 5 2.14 2.14 HS.48447 0.39 -0.30 1.83 2.44 -0.58 1 2 3 4 5 2.14 2.14 XKR7 1.84 0.16 2.29 2.36 -1.21 1 2 3 4 5 2.13 2.13 KCNE2 -0.42 -0.24 1.90 2.19 -0.35 1 2 3 4 5 2.13 2.13 WDR66 -0.77 0.06 2.19 -0.04 0.55 1 2 3 4 5 2.13 2.13 HS.571643 -0.23 -0.56 1.57 2.47 2.62 1 2 3 4 5 2.13 2.13 C10RF168 -0.17 -0.95 1.18 1.93 1.09 1 2 3 4 5 2.13 2.13 HS.562874 0.05 0.28 2.41 3.24 -0.24 1 2 3 4 5 2.13 2.13 LOC649593 -0.81 -0.45 1.68 0.42 -0.47 1 2 3 4 5 2.13 2.13 OR9K2 1.24 0.42 2.55 1.77 -0.55 1 2 3 4 5 2.13 2.13 HS.306721 -0.34 3.61 5.73 0.43 -0.12 1 2 3 4 5 2.13 2.13 LOC651829 -0.57 -0.72 1.41 1.43 -0.58 1 2 3 4 5 2.12 2.12 HS.538931 4.36 0.84 2.97 -0.68 -0.51 1 2 3 4 5 2.12 2.12 HS.538498 -1.14 0.64 2.76 0.00 0.83 1 2 3 4 5 2.12 2.12 HS.570383 0.82 -0.55 1.56 -0.70 -0.33 1 2 3 4 5 2.12 2.12 ATXN7 -0.40 -0.47 1.65 3.60 -0.60 1 2 3 4 5 2.12 2.12 HS.584618 1.44 0.26 2.37 -0.13 0.54 1 2 3 4 5 2.11 2.11 HS.575308 0.03 -0.22 1.89 -0.16 -0.80 1 2 3 4 5 2.11 2.11 NUP210L -0.59 -1.00 1.11 3.34 -0.22 1 2 3 4 5 2.11 2.11 CDH10 5.08 -0.75 1.35 0.52 2.28 1 2 3 4 5 2.11 2.11 HS.382116 -0.70 -0.55 1.56 2.19 -0.47 1 2 3 4 5 2.11 2.11 LOC340511 -0.17 0.74 2.84 1.32 0.43 1 2 3 4 5 2.11 2.11 HS.584264 1.49 -0.43 1.67 -0.19 -0.89 1 2 3 4 5 2.10 2.10 HS.577376 2.12 -0.30 1.80 0.03 0.67 1 2 3 4 5 2.10 2.10 LOC653581 1.18 0.33 2.43 1.82 0.09 1 2 3 4 5 2.10 2.10 LOC644767 -0.95 -0.98 1.12 -0.71 1.77 1 2 3 4 5 2.10 2.10 HS.369415 -0.89 0.31 2.41 -0.78 0.25 1 2 3 4 5 2.10 2.10 SLC6A17 0.14 -0.52 1.58 -0.52 0.66 1 2 3 4 5 2.10 2.10 HS.542578 0.42 -0.05 2.05 0.28 0.25 1 2 3 4 5 2.10 2.10 NKX6-1 -0.13 -1.18 0.92 -1.13 -1.09 1 2 3 4 5 2.10 2.10 HS.544389 -1.17 -0.89 1.21 -0.55 1.28 1 2 3 4 5 2.10 2.10 C150RF53 -0.54 -0.96 1.14 -0.78 -1.06 1 2 3 4 5 2.10 2.10 MOGAT3 0.03 0.38 2.48 1.53 0.33 1 2 3 4 5 2.10 2.10 LOC646445 -0.43 -0.85 1.25 -0.41 -0.13 1 2 3 : 4 5 2.10 2.10 HS.538079 0.36 -0.34 1.75 0.07 -0.07 1 2 3 4 5 2.09 2.09 C10ORF91 -0.05 0.05 2.14 0.01 -0.40 1 2 3 4 5 2.09 2.09 HS.365163 2.06 -1.01 1.08 0.63 -0.71 1 2 3 4 2.09 2.09 LOC646914 1.72 0.82 2.91 -0.36 0.69 1 2 3 4 5 2.09 2.09 HS.580051 1.04 0.95 3.04 -0.19 -0.09 1 2 3 4 5 2.09 2.09 HS.68065 0.35 -0.42 1.67 -0.40 0.96 1 2 3 4 5 2.09 2.09 LOC644046 0.05 0.14 2.23 0.23 1.08 1 2 3 4 5 2.09 2.09 Table 3 64 HS.379330 -0.21 -0.23 1.86 0.08 -0.22 1 2 3 4 5 2.09 2.09 HS.545841 -0.64 -0.56 1.53 0.57 0.02 1 2 3 4 5 2.09 2.09 OR8B2 1.44 -0.58 1.51 -0.65 0.96 1 2 3 4 5 2.09 2.09 HS.200878 0.85 -0.58 1.50 2.76 -0.62 1 2 3 4 5 2.09 2.09 HS.584109 4.17 0.07 2.16 0.21 0.20 1 2 3 4 5 2.08 2.08 CD207 0.66 -1.35 0.73 0.68 0.44 1 2 3 4 5 2.08 2.08 LRRC4 -0.76 -0.85 1.23 -0.66 -0.98 1 2 3 4 5 2.08 2.08 HS.540640 1.65 -0.71 1.37 0.55 -0.66 1 2 3 4 5 2.08 2.08 PACRG -0.33 -0.32 1.76 -0.67 -0.01 1 2 3 4 5 2.08 2.08 HS.540031 -0.27 -0.22 1.86 0.19 -0.10 1 2 3 4 5 2.08 2.08 HS.336681 4.51 -2.28 -0.20 -0.57 -1.48 1 2 3 4 5 2.08 2.08 HS.542738 -0.13 0.35 2.42 1.34 0.24 1 2 3 4 5 2.08 2.08 OR10G8 1.30 -0.72 1.35 0.48 3.61 1 2 3 4 5 2.08 2.08 HHCM 1.68 0.38 2.45 0.95 -0.61 1 2 3 4 5 2.08 2.08 LOC648570 -0.34 0.05 2.12 -0.17 -0.11 1 2 3 4 5 2.07 2.07 HS.571300 -0.63 0.80 2.88 0.05 -0.28 1 2 3 4 5 2.07 2.07 HS.542460 -0.12 -0.06 2.02 0.04 0.01 1 2 3 4 5 2.07 2.07 LOC645687 0.56 -0.55 1.53 0.67 2.03 1 2 3 4 5 2.07 2.07 HS.566200 0.39 -0.03 2.04 -0.17 -0.58 1 2 3 4 5 2.07 2.07 SLC22A25 -0.19 -1.86 0.21 -1.87 0.13 1 2 3 4 5 2.07 2.07 LOC652783 0.45 -0.45 1.62 0.91 0.63 1 2 3 4 5 2.07 2.07 FU36157 -0.51 -0.45 1.62 -0.44 -0.42 1 2 3 4 5 2.07 2.07 HS.541659 0.28 1.91 3.97 2.23 1.91 1 2 3 4 5 2.07 2.07 HS.557435 1.78 -0.24 1.83 -0.42 -0.57 1 2 3 4 5 2.07 2.07 ST0N2 -0.93 -0.52 1.55 -1.01 -0.13 1 2 3 4 5 2.07 2.07 HS.544128 1.64 -0.53 1.53 -0.11 -0.14 1 2 3 4 5 2.07 2.07 CREB3L3 0.34 -1.14 0.93 -1.02 -0.25 1 2 3 4 5 2.06 2.06 HS.539626 -0.58 -0.55 1.51 0.52 0.45 1 2 3 4 5 2.06 2.06 HS.545165 2.55 0.43 2.50 0.27 3.10 1 2 3 4 5 2.06 2.06 HS.570272 0.68 1.85 3.91 -0.39 -0.48 1 2 3 4 5 2.06 2.06 HS.333633 1.40 0.13 2.19 0.86 0.20 1 2 3 4 5 ; 2.06 2.06 HS.274837 -0.19 0.25 2.31 1.25 0.31 1 2 3 4 5 2.06 2.06 HS.541530 -0.37 -0.69 1.37 -0.39 -0.45 1 2 3 4 5 2.06 2.06 CXORF48 2.90 -0.71 1.35 0.31 0.60 1 2 3 4 5 2.06 2.06 HS.564855 1.40 -0.30 1.76 -0.33 0.47 1 2 3 4 5 2.06 2.06 HS.543032 -0.28 1.16 3.21 0.16 -0.49 1 2 3 4 5 2.06 2.06 LOC441316 -0.08 -0.36 1.69 0.39 0.66 1 2 3 4 5 2.06 2.06 KCNIPl -0.80 -0.72 1.33 0.15 1.47 1 2 3 4 5 2.06 2.06 HS.583993 -0.24 -0.68 1.37 -0.16 0.28 1 2 3 4 5 2.06 2.06 PNLIP 0.24 -0.13 1.92 0.34 0.88 1 2 3 4 5 2.05 2.05 MGC44328 1.47 0.02 2.07 -1.04 1.49 1 2 3 4 5 2.05 2.05 LOC400858 0.97 -0.18 1.87 2.09 1.42 1 2 3 4 5 2.05 2.05 DKFZP434I1020 -0.66 -0.62 1.44 0.79 0.91 1 2 3 4 5 2.05 2.05 H0XA7 1.54 -0.42 1.63 0.63 -0.49 1 2 3 4 5 2.05 2.05 HS.538375 0.05 -0.14 1.91 -0.17 0.06 1 2 3 4 5 2.05 2.05 HPCA -0.05 -0.59 1.46 -0.24 -0.44 1 2 3 4 5 2.05 2.05 LOC648855 -0.79 -0.50 1.55 -0.14 -0.77 1 2 3 4 5 2.05 2.05 HS.547870 0.95 1.00 3.04 0.66 -0.09 1 2 3 4 5 2.05 2.05 HS.540554 1.04 -0.24 1.80 1.18 0.14 1 2 3 4 5 2.05 2.05 Table 3 65 TCEAL5 -0.36 -0.55 1.50 -0.20 0.11 1 2 3 4 5 2.05 2.05 LOC254028 0.49 -0.47 1.58 0.20 1.05 1 2 3 4 5 2.04 2.04 HS.526491 1.55 0.04 2.09 2.71 0.14 1 2 3 4 5 2.04 2.04 HS.581638 0.11 0.42 2.46 0.15 -0.53 1 2 3 4 5 2.04 2.04 HS.538983 -0.71 -0.44 1.60 -0.20 0.14 1 2 3 4 5 2.04 2.04 CXORF22 -0.38 -0.70 1.34 -0.92 -1.05 1 2 3 4 5 2.04 2.04 DDC 1.90 0.24 2.27 -0.66 0.14 1 2 3 4 5 2.04 2.04 PDE3A -0.53 0.18 2.22 -0.15 0.90 1 2 3 4 5 2.04 2.04 HS.573503 -0.73 -0.70 1.33 0.84 0.30 1 2 3 4 5 2.04 2.04 LOC442570 -0.47 0.06 2.09 0.82 0.09 1 2 3 4 5 2.04 2.04 HS.565520 -1.04 -0.74 1.29 1.45 -1.27 1 2 3 4 5 2.03 2.03 HS.576017 -0.05 -0.04 1.99 0.02 0.14 1 2 3 4 5 2.03 2.03 HS.460872 -0.20 -0.06 1.97 0.24 -0.41 1 2 3 4 5 2.03 2.03 ZIC3 1.10 -1.73 0.30 1.45 -0.73 1 2 3 4 5 2.03 2.03 HS.565823 0.32 -0.40 1.63 0.82 -0.51 1 2 3 4 5 2.03 2.03 HS.570423 -0.02 0.67 2.70 0.18 0.11 1 2 3 4 5 2.03 2.03 PRTG 0.42 -0.72 1.30 -1.58 0.29 1 2 3 4 5 2.03 2.03 LOC644658 0.02 2.58 4.60 0.66 0.73 1 2 3 4 5 2.02 2.02 LOC650879 -0.58 -0.62 1.40 -0.62 1.23 1 2 3 4 5 2.02 2.02 XAGE1D 0.74 -0.58 1.44 -0.36 -0.21 1 2 3 4 5 2.02 2.02 HS.557576 -0.36 -0.37 1.65 -0.33 0.26 1 2 3 4 5 2.02 2.02 HS.584632 1.38 -0.78 1.24 -0.35 0.29 1 2 3 4 5 2.02 2.02 HS.544184 -0.78 -0.40 1.62 0.05 1.58 1 2 3 4 5 2.02 2.02 HS.533846 1.16 0.06 2.08 -0.12 1.44 1 2 3 4 5 2.01 2.01 HS.557625 Ο.79 -0.26 1.75 0.07 -0.19 1 2 3 4 5 2.01 2.01 HS.333688 1.67 -0.35 1.67 -0.33 1.95 1 2 3 4 5 2.01 2.01 HS.579567 -0.25 0.13 2.14 0.32 -0.46 1 2 3 4 5 2.01 2.01 LOC644278 1.63 -0.50 1.51 0.04 1.46 1 2 3 4 5 2.01 2.01 HS.538774 -0.01 0.28 2.29 -0.45 1.47 1 2 3 4 5 2.01 2.01 NXPH2 4.98 -0.86 1.15 -0.01 1.76 1 2 3 4 5 2.01 2.01 EVX2 1.34 -1.19 0.82 -0.92 -0.66 1 2 3 4 5 ; 2.01 2.01 MGC16291 4.47 -0.62 1.38 2.18 3.58 1 2 3 4 5 2.01 2.01 LOC441196 1.60 0.52 2.52 1.50 -0.71 1 2 3 4 5 2.00 2.00 IL33 0.89 -0.74 1.26 -0.33 1.48 1 2 3 4 5 2.00 2.00 LOC649504 -1.06 0.59 2.59 0.29 0.59 1 2 3 4 5 2.00 2.00 HS.573028 1.34 -0.67 1.33 1.83 2.72 1 2 3 4 5 2.00 2.00 HS.564870 0.69 0.85 2.85 1.56 0.43 1 2 3 4 5 2.00 2.00 MST1R -1.76 0.49 2.48 0.95 0.45 1 2 3 4 5 2.00 2.00 HS.508652 0.52 -0.29 1.70 1.26 -0.30 1 2 3 4 5 2.00 2.00 HS.162426 2.69 0.56 2.56 -0.04 0.38 1 2 3 4 5 2.00 2.00 LOC728493 -0.67 -0.21 1.79 0.09 3.79 1 2 3 4 5 2.00 2.00 HS.16633 -0.33 -0.93 1.06 2.67 -0.53 1 2 3 4 5 1.99 1.99 HS.572005 -0.69 -0.91 1.09 0.80 0.35 1 2 3 4 5 1.99 1.99 HS.149883 0.69 -0.43 1.56 2.42 1.79 1 2 3 4 5 1.99 1.99 LOC644059 -0.09 -0.77 1.22 -0.41 -0.13 1 2 3 4 5 1.99 1.99 HS.557989 -0.29 -0.81 1.18 -0.49 0.05 1 2 3 4 5 1.99 1.99 HS.544594 0.07 -0.03 1.96 -0.95 -0.75 1 2 3 4 5 1.99 1.99 C100RF107 -0.03 -0.59 1.40 0.88 0.70 1 2 3 4 5 1.99 1.99 HS.565315 -0.03 -0.78 1.21 1.04 -0.46 1 2 3 4 5 1.99 1.99 Table 3 66 PENK -0.18 -0.08 1.91 0.50 0.26 1 2 3 4 5 1.99 1.99 LOC646566 0.49 -0.73 1.26 0.05 1.07 1 2 3 4 5 1.99 1.99 LOC650148 -0.32 -0.41 1.58 -0.35 1.53 1 2 3 4 5 1.99 1.99 HS.520343 -0.17 -0.37 1.62 -0.23 1.10 1 2 3 4 5 1.99 1.99 APC -0.22 -0.33 1.66 -0.25 -0.26 1 2 3 4 5 1.98 1.98 PDPN 0.23 0.19 2.18 -0.15 -0.42 1 2 3 4 5 1.98 1.98 HS.116323 2.76 -0.49 1.49 -0.46 2.12 1 2 3 4 5 1.98 1.98 HS.564790 -1.05 -0.73 1.25 0.41 0.39 1 2 3 4 5 1.98 1.98 ADAMTS18 0.00 -0.26 1.72 -0.40 -0.10 1 2 3 4 5 1.98 1.98 HS.366725 -1.06 -0.66 1.32 -0.45 0.40 1 2 3 4 5 1.98 1.98 HS.541913 4.53 -0.12 1.86 1.33 0.90 1 2 3 4 5 1.98 1.98 HS.539602 -0.08 0.07 2.05 -0.14 0.38 1 2 3 4 5 1.98 1.98 HS.573537 -0.11 -0.26 1.71 0.32 -0.17 1 2 3 4 5 1.98 1.98 PDE1C 0.35 -0.56 1.41 -0.23 0.00 1 2 3 4 5 1.98 1.98 HS.580517 2.37 -0.70 1.27 0.69 3.98 1 2 3 4 5 1.98 1.98 HS.545646 -0.71 -0.94 1.04 0.91 -1.21 1 2 3 4 5 1.97 1.97 LOC652160 1.52 0.15 2.13 0.21 0.21 1 2 3 4 5 1.97 1.97 KIF18B 1.49 0.32 2.29 0.57 0.02 1 2 3 4 5 1.97 1.97 ZNF391 0.53 -1.61 0.36 -0.86 1.69 1 2 3 4 5 1.97 1.97 ARL9 0.29 -1.20 0.77 -0.10 0.27 1 2 3 4 5 1.97 1.97 HS.558261 0.67 -0.33 1.64 0.23 0.13 1 2 3 4 5 1.97 1.97 HS.538415 -0.04 -0.20 1.78 0.17 0.22 1 2 3 4 5 1.97 1.97 MC2R 5.22 -1.41 0.56 0.16 -0.85 1 2 3 4 5 1.97 1.97 CXCL2 -0.43 -0.43 1.55 -0.16 1.03 1 2 3 4 5 1.97 1.97 HS.581861 -0.62 -0.41 1.56 -1.30 -0.22 1 2 3 4 5 1.97 1.97 HS.524010 -0.10 -0.30 1.67 0.54 1.12 1 2 3 4 5 1.97 1.97 NKX1-2 -0.64 0.94 2.91 0.89 -0.84 1 2 3 4 5 1.97 1.97 HS.544500 0.40 -0.24 1.73 0.15 0.49 1 2 3 4 5 1.97 1.97 HS.537571 -0.47 -0.94 1.02 0.48 -0.76 1 2 3 4 5 1.97 1.97 HS.582533 -0.38 0.85 2.82 -0.30 -0.27 1 2 3 4 5 1.97 1.97 IQUB -0.47 0.23 2.19 -0.09 -0.17 1 2 3 4 5 1.96 1.96 LOC647156 -0.32 0.05 2.01 -0.01 1.16 1 2 3 4 5 1.96 1.96 LOC653437 2.03 -0.38 1.58 0.27 -0.42 1 2 3 4 5 1.96 1.96 LOC440795 0.61 -0.07 1.89 -0.12 0.83 1 2 3 4 5 1.96 1.96 C40RF26 -0.59 -0.66 1.29 -0.46 0.67 1 2 3 4 5 1.96 1.96 S0HLH2 -0.59 0.10 2.05 0.04 1.78 1 2 3 4 1.96 1.96 HS.544783 0.70 -0.05 1.91 0.77 3.03 1 2 3 4 1.96 1.96 NUDT12 0.01 0.59 2.54 -0.90 -1.32 1 2 3 4 5 1.96 1.96 KCNH1 0.66 -0.64 1.31 0.72 -0.72 1 2 3 4 5 1.95 1.95 MASP2 0.17 -0.62 1.34 -1.07 0.19 1 2 3 4 5 1.95 1.95 ICEBERG -0.91 -0.38 1.57 -0.17 -0.53 1 2 3 4 5 1.95 1.95 LOC641751 2.35 -0.67 1.28 -0.30 0.22 1 2 3 4 5 1.95 1.95 CXORF50 -0.53 0.09 2.04 -0.58 -0.57 1 2 3 4 5 1.95 1.95 UGT1A3 -0.63 -0.44 1.51 0.72 1.22 1 2 3 4 5 1.95 1.95 HS.544210 -0.66 -0.54 1.41 -0.46 0.05 1 2 3 4 5 ; 1.95 1.95 BARHL2 -0.83 -0.59 1.36 -0.24 1.45 1 2 3 4 5 1.95 1.95 HS.307772 -0.48 -0.62 1.33 0.70 1.15 1 2 3 4 5 1.95 1.95 HS.550811 -0.96 -0.68 1.27 -0.68 0.07 1 2 3 4 5 1.95 1.95 HS.564561 1.88 -0.52 1.42 -0.28 -0.57 1 2 3 4 5 1.95 1.95 Table 3 67 KRTAP4-5 -0.27 -0.73 1.22 -1.56 -0.07 1 2 3 4 5 1.95 1.95 HS.578716 -0.62 -0.96 0.98 -0.36 -0.42 1 2 3 4 5 1.94 1.94 LOC646719 -1.07 -1.13 0.81 -0.66 -0.81 1 2 3 4 5 1.94 1.94 LOC650323 2.04 -0.15 1.80 0.73 -0.91 1 2 3 4 5 1.94 1.94 GPR172B -0.47 0.12 2.06 0.74 -0.57 1 2 3 4 5 1.94 1.94 ATXN80S 0.49 -0.55 1.39 -0.35 0.69 1 2 3 4 5 1.94 1.94 HS.364959 -0.85 -0.87 1.08 -1.21 0.23 1 2 3 4 5 1.94 1.94 HS.98665 -0.52 -1.11 0.83 -0.63 -1.59 1 2 3 4 5 1.94 1.94 OR2T10 -1.78 -1.49 0.45 -0.55 1.95 1 2 3 4 5 1.94 1.94 LOC401072 -0.74 -0.33 1.61 -0.20 0.82 1 2 3 4 5 1.94 1.94 HS.566493 1.51 -1.13 0.81 -0.36 2.70 1 2 3 4 5 1.94 1.94 HS.59908 1.16 -0.27 1.67 0.74 0.20 1 2 3 4 5 1.94 1.94 HS.570322 -0.74 -0.47 1.46 -1.34 -0.36 1 2 3 4 5 1.94 1.94 RNF12 -0.90 -0.13 1.81 -0.38 2.62 1 2 3 4 5 1.93 1.93 LOC643936 -0.40 -0.61 1.32 -0.19 0.39 1 2 3 4 5 1.93 1.93 LOXL2 -0.70 -0.98 0.96 -0.03 -0.90 1 2 3 4 5 1.93 1.93 MYH11 2.23 -0.71 1.21 -0.98 0.98 1 2 '3 4 5 1.93 1.93 HS.564788 -0.41 0.09 2.01 -1.24 -0.99 1 2 3 4 5 1.93 1.93 LOC649977 -0.52 -0.90 1.03 -0.36 -0.85 1 2 3 4 5 1.92 1.92 HS.541861 0.60 0.17 2.09 -0.22 -0.33 1 2 3 4 5 1.92 1.92 HS.562309 -0.71 -0.41 1.52 0.08 0.73 1 2 3 4 5 1.92 1.92 CYP2A7 3.08 -0.22 1.70 0.96 -0.30 1 2 3 4 5 1.92 1.92 HS.537781 -1.14 -0.42 1.50 -1.17 -0.61 1 2 3 4 5 1.92 1.92 CLDN3 -0.96 -0.33 1.59 0.77 -0.43 1 2 3 4 5 1.92 1.92 HS.516464 -0.17 -0.18 1.73 -0.47 -0.54 1 2 3 4 5 1.92 1.92 HS.582313 0.54: 1.38 3.30 -0.18 0.36 1 2 3 4 5 1.92 1.92 KLKBL4 0.89 -0.20 1.72 1.17 -2.05 1 2 3 4 5 1.92 1.92 HS.538657 -0.32 0.11 2.03 0.06 0.85 1 2 3 4 5 1.91 1.91 HS.134829 -0.57 0.40 2.31 0.58 0.35 1 2 3 4 5 1.91 1.91 HS.576997 0.33 -0.32 1.60 0.98 0.85 1 2 3 4 5 1.91 1.91 LOC651963 0.42 -0.27 1.64 -0.29 -0.03 1 2 3 4 5 1.91 1.91 PRAMEF12 -0.64 -0.49 1.42 0.84 0.50 1 2 3 4 5 1.91 1.91 HS.563166 1.39 -0.80 1.11 -0.69 -0.59 1 2 3 4 5 1.91 1.91 HS.584312 -0.20 -0.80 1.11 -0.07 -0.63 1 2 3 4 5 1.91 1.91 TBX2 0.53 -0.49 1.42 1.34 -1.24 1 2 3 4 5 1.91 1.91 BZRPL1 1.44 0.74 2.65 -0.88 1.35 1 2 3 4 5 1.91 1.91 HS.563778 -0.20 -0.19 1.71 0.41 0.55 1 2 3 4 5 1.91 1.91 MCART2 4.56 -1.01 0.90 0.36 -0.52 1 2 3 4 5 1.91 1.91 GPRC5A 3.89 1.09 3.00 1.92 -0.53 1 2 3 4 5 1.91 1.91 HS.529139 -0.20 0.01 1.92 0.14 1.71 1 2 3 4 5 1.91 1.91 MS4A13 0.08 -0.35 1.56 2.27 -0.03 1 2 3 4 5 1.91 1.91 FU25076 1.21 -1.26 0.65 -0.23 0.17 1 2 3 4 5 1.91 1.91 GPR12 1.55 1.52 3.43 1.17 3.95 1 2 3 4 5 1.90 1.90 MAT1A -0.29 -1.62 0.29 -0.32 -0.23 1 2 3 4 5 1.90 1.90 LOC732206 3.46 -0.52 1.38 -0.46 1.21 1 2 3 4 5 1.90 1.90 SERPINA10 -0.38 -1.10 0.80 -0.38 0.01 1 2 3 4 5 1.90 1.90 FU39660 -0.19 0.04 1.94 -0.37 -0.03 1 2 3 4 5 1.90 1.90 MTTP 0.64 -1.06 0.85 -0.08 -1.01 1 2 3 4 5 1.90 1.90 LOC644519 -0.08 -0.25 1.65 -0.32 0.02 1 2 3 4 5 1.90 1.90 Table 3 68 DLX6 3.25 -0.42 1.49 0.24 0.92 1 2 3 4 5 1.90 1.90 IFNA17 -1.47 -0.48 1.42 7.55 0.44 1 2 3 4 5 1.90 1.90 UNCX 0.14 0.16 2.06 -0.05 -0.65 1 2 3 4 5 1.90 1.90 MRGPRX1 0.00 -1.06 0.84 -0.84 -1.82 1 2 3 4 5 1.90 1.90 HS.147006 0.22 -0.43 1.46 -0.73 -0.22 1 2 3 4 5 1.90 1.90 HS.543642 -1.26 -1.62 0.28 3.09 0.22 1 2 3 4 5 1.90 1.90 HS.540292 1.84 -0.67 1.22 -1.52 -0.31 1 2 3 4 5 1.90 1.90 HS.552431 1.43 -0.54 1.35 1.06 0.14 1 2 3 4 5 1.90 1.90 FAM99A -0.75 0.31 2.21 0.89 3.01 1 2 3 4 5 1.90 1.90 HS.130901 -0.67 0.63 2.53 1.11 0.45 1 2 3 4 5 1.90 1.90 HS.520684 -0.23 -0.20 1.69 0.96 -0.04 1 2 3 4 5 1.89 1.89 HS.545351 -0.09 -0.51 1.39 -0.59 -0.57 1 2 3 4 5 1.89 1.89 LOC643428 0.77 -0.16 1.73 0.12 -0.16 1 2 3 4 5 1.89 1.89 HS.561981 1.74 2.25 4.14 -0.22 -0.18 1 2 3 4 5 1.89 1.89 HS.580140 -0.03 0.04 1.93 0.92 -0.46 1 2 3 4 5 1.89 1.89 MAGEB5 -0.52 -0.20 1.69 1.34 -0.18 1 2 3 4 5 1.89 1.89 SLC16A9 0.19 -0.55 1.34 -0.22 -0.16 1 2 3 4 5 1.89 1.89 HS.577871 -0.08 -0.35 1.54 1.11 0.69 1 2 3 4 5 1.89 1.89 MBL2 1.06 -0.90 0.99 -1.31 -1.13 1 2 3 4 5 1.89 1.89 LOC649133 -0.18 -0.60 1.29 -0.31 0.05 1 2 3 4 5 1.89 1.89 HS.122013 -0.49 0.28 2.17 -0.61 -0.19 1 2 3 4 5 1.89 1.89 DEFB32 -0.07 -0.79 1.10 -0.31 -0.32 1 2 3 4 5 1.89 1.89 LOC400406 -1.26 -0.92 0.97 1.35 0.31 1 2 3 4 5 1.89 1.89 LOC641905 3.20 -1.35 0.53 1.30 0.68 1 2 3 4 5 1.89 1.89 C160RF82 0.26 0.20 2.08 -1.19 -0.34 1 2 3 4 5 1.89 1.89 RBP3 0.54 0.94 2.82 -1.07 0.17 1 2 3 4 5 1.89 1.89 HS.19193 0.28 -0.62 1.26 -0.17 -0.24 1 2 3 4 5 1.89 1.89 S0X11 0.08 -1.00 0.88 1.76 0.36 1 2 3 4 5 1.88 1.88 HS.382309 -0.01 -0.13 1.76 -0.02 0.18 1 2 3 4 5 1.88 1.88 HS.543556 -0.04 -1.60 0.28 -0.61 -0.51 1 2 3 4 5 1.88 1.88 CYP2C9 0.95 -1.18 0.70 -0.61 0.01 1 2 3 4 5 1.88 1.88 LOC643318 0.34 -0.69 1.19 0.17 1.57 1 2 3 4 5 1.88 1.88 HS.442505 1.40 -0.40 1.47 1.44 -1.46 1 2 3 4 5 1.88 1.88 TTLL8 0.09 -0.06 1.82 -0.36 0.28 1 2 3 4 5 1.87 1.87 C20ORF70 -0.13 -0.09 1.78 -0.16 -0.10 1 2 3 4 5 1.87 1.87 SRMS -0.80 -0.70 1.17 -0.57 -0.66 1 2 3 4 5 1.87 1.87 LOC649635 0.19 0.55 2.43 -0.32 -0.33 1 2 3 4 5 1.87 1.87 HS.371083 -0.58 0.08 1.95 -0.57 0.25 1 2 3 4 5 1.87 1.87 HS.274593 1.74 -0.15 1.72 -0.03 -0.17 1 2 3 4 5 1.87 1.87 IHH 1.54 -0.17 1.70 -0.20 0.39 1 2 3 4 5 1.87 1.87 HS.539207 -0.36 -0.38 1.49 -0.21 -0.07 1 2 3 4 5 1.87 1.87 HS.454803 1.21 -0.98 0.89 2.86 0.16 1 2 3 4 5 1.87 1.87 OR6T1 0.62 -0.89 0.98 -0.61 0.63 1 2 3 4 5 1.87 1.87 S100A7 -0.50 -1.57 0.29 1.78 2.31 1 2 3 4 5 1.87 1.87 LOC641942 0.56 0.35 2.21 -0.40 -0.50 1 2 3 4 5 1.86 1.86 C9 1.29 -0.61 1.26 -0.58 0.91 1 2 3 4 5 1.86 1.86 HS.579025 1.12 -0.01 1.85 1.26 2.11 1 2 3 4 5 1.86 1.86 HS.580882 -0.71 -0.83 1.03 -0.54 -0.33 1 2 3 4 5 1.86 1.86 HS.566355 -0.24 -0.66 1.20 -0.25 0.01 1 2 3 4 5 1.86 1.86 Table 3 69 HS.59203 0.16 0.07 1.93 -0.28 0.98 1 2 3 4 5 1.86 1.86 OR4N2 -0.39 -0.76 1.10 -0.60 -0.05 1 2 3 4 5 1.86 1.86 EG 4 -0.93 -0.34 1.51 -0.58 4.42 1 2 3 4 5 1.86 1.86 C140RF37 -0.86 -1.24 0.61 0.28 0.36 1 2 3 4 5 1.86 1.86 C120RF54 -0.59 -0.71 1.15 -0.12 -0.69 1 2 3 4 5 1.86 1.86 LOC652355 -0.33 0.42 2.27 0.35 -0.09 1 2 3 4 5 1.85 1.85 PTPRG -0.18 -0.40 1.45 -0.15 -0.14 1 2 3 4 5 1.85 1.85 HS.567015 0.46 0.16 2.01 -0.15 -0.68 1 2 3 4 5 1.85 1.85 TMEM184A -0.43 0.06 1.91 -0.10 -0.73 1 2 3 4 5 1.85 1.85 LOC652779 0.57 -0.26 1.59 -0.11 1.52 1 2 3 4 5 1.85 1.85 C1ORF210 -0.02 -0.11 1.74 1.08 0.32 1 2 3 4 5 1.85 1.85 TPH2 0.19 -0.82 1.03 -0.11 1.99 1 2 3 4 5 1.85 1.85 M0RN1 -0.62 -0.60 1.25 -0.09 -0.29 1 2 3 4 5 1.85 1.85 HS.121401 -0.40 -0.27 1.57 -0.18 0.16 1 2 3 4 5 1.84 1.84 NAP5 1.60 -1.87 -0.03 -0.32 -1.88 1 2 3 4 5 1.84 1.84 HS.554651 -0.35 -0.42 1.42 -0.39 -0.39 1 2 3 4 5 1.84 1.84 HS.578246 -0.83 0.33 2.18 0.51 -1.08 1 2 3 4 5 1.84 1.84 OR52B4 4.09 -0.59 1.25 1.76 -1.59 1 2 3 4 5 1.84 1.84 LOC648639 -1.34 -0.59 1.25 0.33 1.75 1 2 3 4 5 1.84 1.84 HS.169815 -0.27 -0.39 1.46 -0.40 0.80 1 2 3 4 5 1.84 1.84 HS.543339 2.62 0.32 2.16 1.00 0.98 1 2 3 4 5 1.84 1.84 C110RF44 -0.69 0.59 2.43 0.50 -0.35 1 2 3 4 5 1.84 1.84 KRTAP12-3 1.90 -0.87 0.97 -0.47 0.46 1 2 3 4 5 1.84 1.84 HS.62930 -0.46 0.21 2.05 0.78 -0.12 1 2 3 4 5 1.84 1.84 OR2AT4 -0.96 -0.40 1.44 0.25 0.10 1 2 3 4 5 1.84 1.84 MS4A15 0.15 -1.16 0.68 -0.35 -0.07 1 2 3 4 5 1.84 1.84 PP8961 1.47 0.23 2.07 0.07 -0.08 1 2 3 4 5 1.84 1.84 HHLA2 -1.09 -0.97 0.86 -0.90 0.30 1 2 3 4 5 1.84 1.84 LPHN3 1.23 -0.08 1.75 -1.09 -1.51 1 2 3 4 5 1.83 1.83 GDF9 0.05 0.45 2.29 0.64 -0.16 1 2 3 4 5 1.83 1.83 HS.89257 0.40 -0.15 1.68 -0.19 0.78 1 2 3 4 5 1.83 1.83 BBOX1 0.14 -0.89 0.94 -0.56 -0.20 1 2 3 4 5 1.83 1.83 C20RF39 2.68- -0.16 1.67 1.08 0.23 1 2 3 4 5 1.83 1.83 LOC652215 -0.41 -0.34 1.49 -0.37 -0.25 1 2 3 4 5 1.83 1.83 RC3H1 -0.48 -0.39 1.44 -0.47 -0.36 1 2 3 4 5 1.83 1.83 HS.544133 -0.16 -0.68 1.15 -0.54 -0.18 1 2 3 4 5 1.83 1.83 LOC441436 1.32 -0.30 1.53 1.00 -0.36 1 2 3 4 5 1.83 1.83 HS.438486 -0.42 0.23 2.06 0.25 0.24 1 2 3 4 5 1.83 1.83 LOC643700 -0.49 0.13 1.96 -0.48 0.39 1 2 3 4 1.83 1.83 HS.541187 0.62 -0.02 1.81 0.26 0.59 1 2 3 4 1.82 1.82 CASKIN1 1.17 -0.62 1.20 0.92 1.38 1 2 3 4 5 1.82 1.82 HS.127008 -0.69 0.36 2.18 0.96 -0.09 1 2 3 4 5 1.82 1.82 PAQR9 0.74 1.61 3.43 -0.59 1.45 1 2 3 4 5 1.82 1.82 HS.539881 -1.26 -0.71 1.11 1.43 2.53 1 2 3 4 5 1.82 1.82 HS.578449 0.11 0.79 2.61 2.93 1.66 1 2 3 4 5 1.82 1.82 MAGI1 -1.29 -0.98 0.84 -0.40 -1.15 1 2 3 4 5 1.82 1.82 HS.531407 -0.74 -0.34 1.48 -0.63 -0.62 1 2 3 4 5 1.82 1.82 HS.562501 0.24 0.31 2.13 0.43 0.44 1 2 3 4 5 1.82 1.82 HS.565382 -2.34 2.85 4.67 -1.23 0.15 1 2 3 4 5 1.82 1.82 Table 3 70 CCK -1.00 -1.06 0.76 0.65 0.90 1 2 3 4 5 1.82 1.82 HS.119816 0.63 -1.64 0.18 2.06 3.43 1 2 3 4 5 1.82 1.82 HS.565519 1.77 0.78 2.59 0.49 -0.40 1 2 3 4 5 1.82 1.82 PGBD5 -0.39 -0.12 1.70 -0.17 1.01 1 2 3 4 5 1.81 1.81 HS.544060 -0.32 -0.22 1.59 -0.77 0.16 1 2 3 4 5 1.81 1.81 HS.581151 -0.09 -0.37 1.45 -0.01 0.06 1 2 3 4 5 1.81 1.81 LOC651430 0.00 0.01 1.83 0.07 -0.28 1 2 3 4 5 1.81 1.81 BSND -0.10 0.20 2.01 0.23 0.10 1 2 3 4 5 1.81 1.81 HS.176479 -0.11 -0.77 1.04 0.34 -0.77 1 2 3 4 5 1.81 1.81 C40RF38 -0.53 -0.75 1.06 -0.34 0.41 1 2 3 4 5 1.81 1.81 HS.563175 -1.05 -0.63 1.18 -0.01 -0.21 1 2 3 4 5 1.81 1.81 HS.538567 -0.08 -0.45 1.36 0.21 0.31 1 2 3 4 5 1.81 1.81 FLNC 0.47 -2.00 -0.19 2.23 0.23 1 2 3 4 5 1.81 1.81 HS.539346 4.60 -0.15 1.65 -0.81 -0.91 1 2 3 4 5 1.81 1.81 HHIPL2 -0.11 -0.41 1.39 -0.24 -0.11 1 2 3 4 5 1.81 1.81 HS.539865 3.13 0.72 2.52 0.21 2.84 1 2 3 4 5 1.80 1.80 C190RF51 -0.62 -0.57 1.23 0.07 -0.28 1 2 3 4 5 1.80 1.80 LOC652251 1.42 -0.59 1.21 0.01 0.11 1 2 3 4 5 1.80 1.80 HS.545370 0.59 -0.68 1.12 0.07 0.17 1 2 3 4 5 1.80 1.80 HS.542636 -1.02 -0.14 1.66 -0.26 0.85 1 2 3 4 5 1.80 1.80 HS.353024 0.09 -0.63 1.17 0.14 -0.18 1 2 3 4 5 1.80 1.80 HS.575187 -1.20 0.26 2.06 3.44 -0.81 1 2 3 4 5 1.80 1.80 HS.580735 0.63 2.05 3.85 1.94 3.78 1 2 3 4 5 1.80 1.80 HS.364956 -0.34 -0.97 0.83 -0.33 0.34 1 2 3 4 5 1.80 1.80 FU16124 -1.45 -0.89 0.90 -1.89 0.55 1 2 3 4 5 1.80 1.80 LOC729399 -0.21 -0.36 1.44 0.50 0.23 1 2 3 4 5 1.80 1.80 LOC641741 -0.49 0.39 2.18 1.24 -0.29 1 2 3 4 5 1.79 1.79 MAPK12 -0.16 -0.11 1.68 2.21 0.11 1 2 3 4 5 1.79 1.79 FCN3 -0.36 0.17 1.97 1.61 -0.19 1 2 3 4 5 1.79 1.79 LOC647784 1.66 0.13 1.93 1.36 0.40 1 2 3 4 5 1.79 1.79 HS.553450 -0.14 0.30 2.09 0.08 -0.18 1 2 3 4 5 1.79 1.79 OR5P2 2.87 0.64 2.43 -0.10 0.96 1 2 3 4 5 1.79 1.79 PRSS8 -0.76 -1.01 0.79 -0.38 -0.50 1 2 3 4 5 1.79 1.79 HS.539416 -0.36 0.24 2.03 -0.18 1.02 1 2 3 4 5 1.79 1.79 HS.540911 -0.51 -0.93 0.86 0.22 0.07 1 2 3 4 5 1.79 1.79 HS.544363 1.08 0.41 2.20 2.47 0.57 1 2 3 4 5 1.79 1.79 KPRP 1.36 -0.39 1.40 -0.48 0.76 1 2 3 4 5 1.79 1.79 HS.255086 1.73 -0.29 1.50 -0.15 -0.04 1 2 3 4 5 1.79 1.79 LOC647839 3.45 -0.40 1.39 0.19 0.01 1 2 3 4 5 1.78 1.78 HS.578264 0.60 -0.56 1.22 0.32 0.95 1 2 3 4 5 1.78 1.78 HS.572972 0.33 -0.34 1.45 1.73 -0.70 1 2 3 4 5 1.78 1.78 TLCD1 - 1.17 -0.44 1.35 0.11 0.08 1 2 3 4 5 1.78 1.78 HS.12535 1.43 -1.38 0.40 1.13 0.39 1 2 3 4 5 1.78 1.78 HS.575342 -0.39 -0.34 1.44 0.53 -0.51 1 2 3 4 5 1.78 1.78 CCDC48 -0.96 -0.73 1.05 -0.63 -0.65 1 2 3 4 5 1.78 1.78 LOC729966 -0.05 -0.22 1.56 0.24 1.40 1 2 3 4 5 1.78 1.78 PDE11A -0.34 -1.32 0.46 2.30 0.39 1 2 3 4 5 1.78 1.78 HS.333797 1.64 0.04 1.82 0.07 0.02 1 2 3 4 5 1.78 1.78 LOC648480 1.38 -0.99 0.78 -0.41 -0.71 1 2 3 4 5 1.78 1.78 Table 3 71 HS.565851 3.57 5.00 6.78 1.64 1.14 1 2 3 4 5 1.78 1.78 LOC647666 -0.41 0.26 2.03 0.86 2.34 1 2 3 4 5 1.77 1.77 HS.571672 1.17 -1.38 0.39 2.75 -0.01 1 2 3 4 5 1.77 1.77 LOC344657 -0.74 -0.99 0.79 0.73 0.59 1 2 3 4 5 1.77 1.77 HS.129003 -0.39 -1.89 -0.12 5.40 2.65 1 2 3 4 5 1.77 1.77 CNGA1 3.94 -1.36 0.42 -0.11 0.33 1 2 3 4 5 1.77 1.77 FAM92B -0.42 -0.88 0.89 -0.04 -0.55 1 2 3 4 5 , 1.77 1.77 HS.474112 0.86 -0.60 1.16 4.53 1.95 1 2 3 4 5 1.77 1.77 DEFB106B -0.17 -0.30 1.47 -0.10 -0.08 1 2 3 4 5 1.77 1.77 CCDC42 -0.73 -1.01 0.76 0.49 2.06 1 2 3 4 5 1.77 1.77 SFTPA1B -0.88 -1.40 0.36 -0.54 -0.65 1 2 3 4 5 1.77 1.77 F0XG1 0.88 -0.67 1.10 0.34 -0.22 1 2 3 4 5 1.77 1.77 HS.561798 1.03 -0.61 1.16 -1.01 -0.35 1 2 3 4 5 1.77 1.77 DLG2 2.60 -0.51 1.26 0.93 -0.65 1 2 3 4 5 1.77 1.77 HS.552550 2.56 0.16 1.93 -0.65 1.85 1 2 3 4 5 1.77 1.77 LOC649428 -0.60 -0.65 1.12 -0.37 -0.13 1 2 3 4 5 1.76 1.76 HS.546037 -0.35 -0.20 1.56 0.20 -0.05 1 2 3 4 5 1.76 1.76 FGFR2 0.11 -0.70 1.06 1.26 1.89 1 2 3 4 5 1.76 1.76 HS.576319 0.18 -0.47 1.29 2.59 1.43 1 2 3 4 5 1.76 1.76 HS.525910 -0.80 -0.86 0.91 -0.61 -0.31 1 2 3 4 5 1.76 1.76 HS.132119 -0.72 -0.35 1.41 0.43 2.67 1 2 3 4 5 1.76 1.76 LOC643381 -0.21 0.18 1.94 -0.36 -0.11 1 2 3 4 5 1.76 1.76 PTPRT -0.44 -0.50 1.26 -0.68 -0.09 1 2 3 4 5 1.76 1.76 FAM90A8 0.68 -0.17 1.59 -0.83 -0.42 1 2 3 4 5 1.76 1.76 HS.380012 -0.10 -0.03 1.73 0.26 0.29 1 2 3 4 5 1.76 1.76 HS.579465 -0.35 0.21 1.96 -0.16 0.95 1 2 3 4 5 1.76 1.76 HS.569001 -0.64 -0.51 1.25 0.11 -0.60 1 2 3 4 5 1.76 1.76 LOC647529 -0.14 -0.17 1.59 -0.18 0.46 1 2 3 4 5 1.76 1.76 C1ORF180 -0.31 0.76 2.52 2.23 0.17 1 2 3 4 5 1.76 1.76 HS.582223 -1.02 -1.52 0.23 0.64 -0.97 1 2 3 4 5 1.75 1.75 LOC401923 -0.05 -0.90 0.85 -0.15 1.24 1 2 3 4 5 1.75 1.75 LOC728601 -1.27 -1.53 0.23 1.94 -1.09 1 2 3 4 5 1.75 1.75 HTN1 2.67 -0.86 0.89 -1.02 1.27 1 2 3 4 5 1.75 1.75 TFF2 0.18 0.14 1.89 -0.36 -1.16 1 2 3 4 5 1.75 1.75 DNAH17 -0.72 -0.61 1.14 -0.36 4.46 1 2 3 4 5 1.75 1.75 LOC728723 0.87 -0.53 1.22 -0.29 -0.44 1 2 3 4 5 1.75 1.75 OR51B5 -0.93 -1.08 0.67 -0.50 0.02 1 2 3 4 5 1.75 1.75 LOC199897 -0.29 -0.35 1.40 1.36 -0.11 1 2 3 4 5 1.75 1.75 T C0 2 -0.55 -1.67 0.07 -0.12 -1.15 1 2 3 4 5 1.75 1.75 LRAT -0.28 0.48 2.22 -0.61 0.22 1 2 3 4 5 1.75 1.75 FM03 -0.18 -1.64 0.11 -1.32 -0.37 1 2 3 4 5 1.75 1.75 CDC42BPG -0.78 -1.29 0.45 0.58 3.57 1 2 3 4 5 1.75 1.75 HS.564875 -0.29 -0.03 1.71 1.17 0.66 1 2 3 4 5 1.74 1.74 INHA 1.52 -1.05 0.70 0.14 1.59 1 2 3 4 5 1.74 1.74 HS.538651 -0.51 0.02 1.77 -0.58 0.68 1 2 3 4 5 1.74 1.74 HS.545305 -0.07 -0.88 0.87 2.14 1.35 1 2 3 4 5 1.74 1.74 GDF1 -0.55 -0.50 1.24 -0.65 1.44 1 2 3 4 5 1.74 1.74 HS.581276 0.66 -0.73 1.01 0.61 -0.32 1 2 3 4 5 1.74 1.74 PTPRB -0.48 -0.22 1.52 -0.13 0.78 1 2 3 4 5 1.74 1.74 Table 3 72 HS.176655 -0.77 -1.37 0.37 1.35 0.12 1 2 3 4 5 1.74 1.74 LOC653536 1.48 -1.02 0.72 -0.33 -0.33 1 2 3 4 5 1.74 1.74 LOC649503 -0.68 -0.42 1.32 -0.48 0.22 1 2 3 4 5 1.74 1.74 BRSK2 0.47 -0.79 0.95 -0.06 0.43 1 2 3 4 5 1.74 1.74 HS.154593 0.14 0.25 1.99 -0.34 0.08 1 2 3 4 1.74 1.74 LOC731283 0.62 -0.97 0.77 -0.69 -0.19 1 2 3 4 5 1.74 1.74 HS.277205 2.47 -0.51 1.22 1.84 3.54 1 2 3 4 5 1.74 1.74 HS.571860 1.53 -0.41 1.32 1.03 2.13 1 2 3 4 5 1.74 1.74 LOC641929 1.16 -0.02 1.72 1.44 -0.26 1 2 3 4 5 1.74 1.74 HS.208447 -1.24 -1.52 0.22 0.13 -0.88 1 2 3 4 5 1.74 1.74 HS.377348 0.14 -0.36 1.37 2.35 -0.34 1 2 3 4 5 1.73 1.73 KNG1 -0.23 -0.50 1.23 0.62 -0.32 1 2 3 4 5 1.73 1.73 PTCHD3 0.46 -0.32 1.41 1.64 -0.29 1 2 3 4 5 1.73 1.73 CA9 0.35 -0.23 1.50 -0.18 -0.42 1 2 3 4 5 1.73 1.73 ATP6V0A4 0.52 -0.80 0.93 0.80 0.40 1 2 3 4 5 1.73 1.73 HS.543012 -0.02 1.33 3.05 0.20 0.54 1 2 3 4 5 1.73 1.73 HS.550194 0.28 -0.26 1.46 1.16 1.45 1 2 3 4 5 1.73 1.73 TTTY5 1.50 -0.57 1.16 0.90 0.81 1 2 3 4 5 1.73 1.73 OTUD6A 0.67 -0.11 1.61 0.10 -0.15 1 2 3 4 5 1.73 1.73 HS.573851 -0.08 -0.13 1.60 -0.12 -0.16 1 2 3 4 5 1.73 1.73 OR2W1 -0.28' 1.66 3.39 3.83 -0.22 1 2 3 4 5 1.73 1.73 HS.564415 -0.80 -0.80 0.92 2.06 -0.34 1 2 3 4 5 1.73 1.73 C70RF34 -0.75 0.37 2.09 -0.03 -1.06 1 2 3 4 5 1.72 1.72 HS.540218 -0.17 0.30 2.02 0.67 -0.19 1 2 3 4 5 1.72 1.72 SPINK5L2 1.83 0.78 2.51 -0.52 1.28 1 2 3 4 5 1.72 1.72 HS.447634 -0.19 -0.33 1.40 -0.41 0.10 1 2 3 4 5 1.72 1.72 LOC641805 -0.35 -0.45 1.27 0.83 1.20 1 2 3 4 5 1.72 1.72 C150RF37 0.76 -0.24 1.48 1.65 1.07 1 2 3 4 5 1.72 1.72 HS.195063 -0.11 0.08 1.80 -0.88 0.22 1 2 3 4 5 1.72 1.72 LOC649948 0.53 -0.20 1.52 -0.32 0.87 1 2 3 4 5 1.72 1.72 HS.137025 2.61 -0.86 0.86 0.40 -0.31 1 2 3 4 5 1.72 1.72 ZBTB37 0.82 -1.13 0.59 0.21 -0.70 1 2 3 4 5 1.72 1.72 LOC649217 -0.32 -0.32 1.40 0.00 1.16 1 2 3 4 5 1.72 1.72 HS.539586 1.90 -1.42 0.30 1.12 0.50 1 2 3 4 5 1.72 1.72 HS.437259 0.20 -0.31 1.41 -0.47 -0.55 1 2 3 4 5 1.72 1.72 HS.126605 -0.38 -0.46 1.26 -0.15 0.24 1 2 3 4 5 1.72 1.72 BA9F11.1 2.24 -0.38 1.34 0.62 -0.12 1 2 3 4 5 1.72 1.72 OR6Q1 1.00 -0.28 1.43 2.23 -1.09 1 2 3 4 5 1.72 1.72 MFSD4 1.80 0.01 1.73 -0.05 1.00 1 2 3 4 5 1.71 1.71 C10RF92 -0.36 0.30 2.01 -0.02 1.78 1 2 3 4 5 1.71 1.71 PPP1R1C 0.64 -0.35 1.36 0.37 -0.28 1 2 3 4 5 1.71 1.71 MAGEB1 -1.20 -0.94 0.77 0.12 -0.43 1 2 3 4 5 1.71 1.71 LOC645932 0.70 1.30 3.02 0.63 0.63 1 2 3 4 5 1.71 1.71 MUC17 -0.85 0.27 1.98 0.04 -0.13 1 2 3 4 5 1.71 1.71 HS.482898 -0.73 0.22 1.94 -0.76 -0.99 1 2 3 4 1.71 1.71 0R13D1 -1.41 -0.39 1.32 1.44 -0.97 1 2 3 4 5 1.71 1.71 C6ORF10 -0.16; 0.23 1.94 0.61 0.17 1 2 3 4 5 1.71 1.71 CBLN4 -0.24 -0.40 1.31 0.34 -0.46 1 2 3 4 5 1.71 1.71 HS.540859 3.90 -1.53 0.18 5.16 2.37 1 2 3 4 5 1.71 1.71 Table 3 73 HS.165432 -0.13 -0.35 1.36 -0.23 -0.12 1 2 3 4 5 1.71 1.71 HS.59951 0.15 0.01 1.71 0.42 0.19 1 2 3 4 5 1.70 1.70 HS.565640 -0.29 -0.30 1.40 0.65 -0.28 1 2 3 4 5 1.70 1.70 OR2L2 1.07 -0.01 1.69 2.32 0.05 1 2 3 4 5 1.70 1.70 LOC652258 -0.25 -0.37 1.33 -0.64 -0.62 1 2 3 4 5 : 1.70 1.70 TAS2R50 -1.21 0.28 1.98 1.46 0.63 1 2 3 4 5 1.70 1.70 HS.146859 -0.22 -0.10 1.60 -0.47 0.43 1 2 3 4 5 1.70 1.70 FU45121 0.34 0.17 1.87 0.60 -0.78 1 2 3 4 5 1.70 1.70 HS.574140 0.26 1.11 2.81 0.26 0.11 1 2 3 4 5 1.70 1.70 HS.197031 -0.70 -0.90 0.80 0.34 0.48 1 2 3 4 5 1.70 1.70 IL26 1.68 0.73 2.43 0.89 1.25 1 2 3 4 5 1.70 1.70 HS.544959 0.45 -0.97 0.73 -0.96 1.59 1 2 3 4 5 1.70 1.70 HS.581974 -0.59 -0.16 1.54 -0.47 1.08 1 2 3 4 5 1.70 1.70 LOC643081 -0.80 -0.37 1.32 2.70 0.10 1 2 3 4 5 1.70 1.70 C150RF42 0.54 -0.71 0.98 -1.04 -0.05 1 2 3 4 5 1.70 1.70 MPP3 -0.59 -0.23 1.47 0.32 -0.53 1 2 3 4 5 1.70 1.70 PCDHB1 -0.12 0.65 2.34 1.06 3.10 1 2 3 4 5 1.70 1.70 LRRC18 -0.26 -0.40 1.30 0.25 0.43 1 2 3 4 5 1.70 1.70 HS.538914 -0.41 -0.95 0.75 -0.48 1.26 1 2 3 4 5 1.69 1.69 TMED8 -0.26 0.61 2.30 -0.42 0.11 1 2 3 4 5 1.69 1.69 CST6 -0.88 0.03 1.72 0.21 -0.34 1 2 3 4 5 1.69 1.69 FU37078 -0.85 -0.49 1.20 -0.71 -0.41 1 2 3 4 5 1.69 1.69 HS.491872 -0.53 0.25 1.94 2.01 -0.06 1 2 3 4 5 1.69 1.69 HS.543228 0.79 -0.74 0.95 -0.38 1.24 1 2 3 4 5 1.69 1.69 HS.546046 -0.07 -0.96 0.73 1.99 0.62 1 2 3 4 5 1.69 1.69 HS.562256 -0.08 -1.51 0.18 0.20 0.63 1 2 3 4 5 1.69 1.69 CDC6 0.38 -0.63 1.06 -0.16 0.36 1 2 3 4 5 1.69 1.69 LOC439936 0.31 0.31 2.00 2.24 3.32 1 2 3 4 5 1.69 1.69 RGS20 -1.41 -0.27 1.42 4.14 0.05 1 2 3 4 5 1.69 1.69 HS.567023 -0.42 -0.27 1.42 2.42 -0.42 1 2 3 4 5 1.69 1.69 HS.104823 -0.26 -0.75 0.94 1.07 -0.88 1 2 3 4 5 1.69 1.69 HS.550627 -1.21 -0.55 1.13 -0.58 -0.15 1 2 3 4 5 1.69 1.69 HS.576103 -0.52 -0.19 1.50 0.95 -0.03 1 2 3 4 5 1.69 1.69 OR7E37P -1.05 -0.68 1.01 -0.32 1.06 1 2 3 4 5 1.69 1.69 HS.279227 -0.18 -0.82 0.87 0.68 0.65 1 2 3 4 5 1.69 1.69 SEZ6L2 1.71 -0.72 0.96 -0.67 -0.30 1 2 3 4 5 1.69 1.69 HS.352191 0.77 -0.22 1.47 3.82 -0.34 1 2 3 4 5 1.69 1.69 LOC652710 -0.20 0.93 2.61 -0.01 -0.01 1 2 3 4 5 1.69 1.69 KRTAP13-4 0.64 -0.09 1.60 4.07 0.74 1 2 3 4 5 1.68 1.68 HS.540312 2.97 -0.37 1.32 -0.60 1.56 1 2 3 4 5 1.68 1.68 C120RF61 -0.60 -0.61 1.07 0.84 0.08 1 2 3 4 5 1.68 1.68

C1QTNF7 1.24 0.95 2.63 -1.26 -0.28 1 2 3 4 5 ·· 1.68 1.68 SRPX2 2.42 -0.58 1.09 0.33 0.51 1 2 3 4 5 1.68 1.68 SPATA16 0.51 -0.31 1.37 2.60 -0.22 1 2 3 4 5 1.68 1.68 HS.121108 2.72 0.29 1.96 0.48 0.49 1 2 3 4 5 1.68 1.68 TNFSF18 0.62 -0.51 1.16 -0.20 -0.12 1 2 3 4 5 1.68 1.68 LOC649101 1.56 -0.46 1.22 -0.06 -0.31 1 2 3 4 1.67 1.67 HS.549546 -0.15 -0.53 1.15 -0.47 -0.71 1 2 3 4 5 1.67 1.67 PRKAA2 1.98 -0.32 1.36 0.15 3.33 1 2 3 4 5 1.67 1.67 Table 3 KCNQ5 4.20 -0.14 1.53 2.33 3.99 1 2 3 4 5 1.67 1.67 CCDC37 1.17 -0.34 1.33 -0.53 0.88 1 2 3 4 5 1.67 1.67 OR52A1 -1.28 -0.60 1.06 -1.17 1.62 1 2 3 4 5 1.67 1.67 LOC643302 -0.58 0.75 2.42 0.29 -0.08 1 2 3 4 5 1.67 1.67 HS.440322 0.63 0.09 1.76 1.31 0.70 1 2 3 4 5 1.66 1.66 LOC387762 -0.09 -0.35 1.31 -0.14 0.21 1 2 3 4 1.66 1.66 HS.435979 -0.63 -0.73 0.93 2.31 -0.07 1 2 3 4 5 1.66 1.66 NRXN1 0.44 -0.91 0.76 -0.53 -1.15 1 2 3 4 5 1.66 1.66 COLEC11 -1.07 -1.22 0.44 -0.28 -0.14 1 2 3 4 5 1.66 1.66 CRISPl -0.05 -0.05 1.61 0.07 -1.42 1 2 3 4 5 1.66 1.66 CST5 -0.58 -0.03 1.63 -0.72 -0.35 1 2 3 4 5 1.66 1.66 HS.164225 0.87 -0.03 1.63 0.22 -0.21 1 2 3 4 5 1.66 1.66 SPRR2F 0.39 -0.58 1.08 -0.39 0.17 1 2 3 4 5 1.66 1.66 LOC643194 -0.22 0.01 1.67 2.44 1.62 1 2 3 4 5 1.66 1.66 HS.565735 0.13 -0.62 1.04 -0.47 -0.10 1 2 3 4 5 1.66 1.66 LCE2A 4.49 0.32 1.98 -0.67 0.10 1 2 3 4 5 1.66 1.66 DNAI1 0.24 1.74 3.40 0.61 0.85 1 2 3 4 5 1.66 1.66 HS.542666 -0.23 -0.38 1.28 0.28 0.59 1 2 3 4 5 1.66 1.66 C190RF41 0.60 -1.09 0.56 2.87 1.07 1 2 3 4 5 1.66 1.66 HS.528005 0.83 0.00 1.66 0.93 -0.08 1 2 3 4 5 1.66 1.66 HS.544129 0.77 -0.40 1.25 0.29 0.38 1 2 3 4 5 1.65 1.65 DNAHL1 -0.95 -1.64 0.02 -1.76 -1.10 1 2 3 4 5 1.65 1.65 HS.162062 2.25 -0.61 1.05 1.80 0.44 1 2 3 4 5 1.65 1.65 HIST1H2AJ 1.22 -0.52 1.13 -0.23 -0.98 1 2 3 4 5 1.65 1.65 HS.62772 -0.23 -0.63 1.02 -0.75 -0.90 1 2 3 4 5 1.65 1.65 BPIL1 -0.70 -0.41 1.24 -0.70 -1.32 1 2 3 4 5 1.65 1.65 CHST8 -0.27 0.78 2.43 0.05 0.24 1 2 3 4 5 1.65 1.65 PN A6A 2.03 -0.28 1.37 -0.66 -1.02 1 2 3 4 5 1.65 1.65 HS.565065 -0.24 -0.22 1.43 0.90 -0.17 1 2 3 4 1.65 1.65 HS.575411 -0.41 -0.37 1.28 0.79 1.19 1 2 3 4 5 1.65 1.65 HS.540020 0.44 0.11 1.75 1.57 -0.39 1 2 3 4 5 1.65 1.65 HS.514518 0.57 -0.37 1.28 0.86 -0.38 1 2 3 4 5 1.65 1.65 A4GALT 0.12 -0.17 1.47 0.06 3.10 1 2 3 4 5 1.65 1.65 LOC731438 0.51 -1.41 0.24 1.83 1.82 1 2 3 4 5 1.65 1.65 LOC643416 0.45 0.16 1.81 2.39 -0.45 1 2 3 4 5 1.65 1.65 HS.149995 -0.41 -0.34 1.31 0.21 0.43 1 2 3 4 5 1.65 1.65 LOC649952 -0.58 -0.61 1.04 -0.56 -0.36 1 2 3 4 5 1.64 1.64 HS.449857 0.01 -0.52 1.12 0.11 0.44 1 2 3 4 5 1.64 1.64 HS.216701 -0.96 -1.02 0.62 1.17 1.44 1 2 3 4 5 1.64 1.64 HS.576557 -0.19 -0.47 1.17 0.48 -0.13 1 2 3 4 5 1.64 1.64 LOC440944 -0.53 -0.69 0.95 1.11 0.45 1 2 3 4 5 1.64 1.64 LOC647648 -0.37 -0.72 0.92 0.10 0.52 1 2 3 4 5 1.64 1.64 HS.537617 0.30 -0.16 1.48 0.41 -0.02 1 2 3 4 5 1.64 1.64 FAT4 -0.25 -0.73 0.91 -0.20 -0.37 1 2 3 4 5 1.64 1.64 LOC645012 -0.03 -0.07 1.57 0.08 0.83 1 2 3 4 5 1.64 1.64 HS.519714 0.33 -0.51 1.13 -0.60 -0.85 1 2 3 4 5 1.64 1.64 HS.549727 -0.63 -1.93 -0.29 4.48 -0.26 1 2 3 4 5 1.64 1.64 POPDC3 -0.86 -0.66 0.98 -0.01 -0.83 1 2 3 4 5 1.64 1.64 HS.538036 0.82 -0.12 1.51 1.26 0.79 1 2 3 4 5 1.64 1.64 Table 3 75 HS.569396 -0.70 -0.38 1.26 0.15 -0.64 1 2 3 4 5 1.64 1.64 ARNTL2 -0.58 -0.99 0.65 2.46 0.50 1 2 3 4 5 1.64 1.64 IFNA13 -0.09 -0.26 1.37 0.78 -0.90 1 2 3 4 5 1.64 1.64 LOC645602 2.55 0.16 1.79 -0.66 0.10 1 2 3 4 5 1.63 1.63 LOC642521 0.09 -0.05 1.59 -0.32 1.09 1 2 3 4 1.63 1.63 HS.562452 0.12 1.67 3.30 0.00 0.55 1 2 3 4 5 1.63 1.63 C130RF3 -0.21 -0.48 1.16 -0.23 -0.22 1 2 3 4 5 1.63 1.63 KIAA1881 0.56 0.33 1.96 0.05 0.38 1 2 3 4 5 1.63 1.63 HS.147671 1.07 -0.55 1.08 -1.26 -1.36 1 2 3 4 5 1.63 1.63 HS.144820 0.82 -0.25 1.38 0.84 0.16 1 2 3 4 5 1.63 1.63 LOC152667 0.14 -0.56 1.07 0.34 -1.93 1 2 3 4 5 1.63 1.63 LOC644347 -0.68 -1.53 0.10 0.54 1.98 1 2 3 4 5 1.63 1.63 IGSF10 5.16 -1.18 0.45 -1.38 -0.50 1 2 3 4 5 1.63 1.63 N UR2 -1.11 -1.27 0.36 1.24 0.08 1 2 3 4 5 1.63 1.63 LOC647868 -0.50 0.05 1.68 -1.62 -0.94 1 2 3 4 5 1.63 1.63 HS.561477 1.23 1.79 3.42 1.62 0.33 1 2 3 4 5 1.63 1.63 LOC643951 -0.47 -0.21 1.42 0.10 1.50 1 2 3 4 5 1.63 1.63 BTN1A1 3.56 0.76 2.39 -0.19 3.14 1 2 3 4 5 1.63 1.63 HS.326006 -0.20 -0.07 1.56 0.11 -0.04 1 2 3 4 5 1.63 1.63 HS.22928 -0.39 -0.38 1.25 -0.02 -0.27 1 2 3 4 5 1.63 1.63 LOC647247 -0.60 -1.36 0.27 1.33 -0.04 1 2 3 4 5 1.63 1.63 WIF1 -0.06 -0.79 0.83 -0.06 0.79 1 2 3 4 5 1.63 1.63 LOC642681 1.22 -0.37 1.25 2.98 1.21 1 2 3 4 5 1.63 1.63 SHF -0.03 -0.07 1.56 -0.04 0.05 1 2 3 4 5 1.62 1.62 LOC644843 -0.40 0.72 2.34 0.31 0.16 1 2 3 4 5 1.62 1.62 CRISPLD1 1.29 -1.09 0.53 0.22 -0.90 1 2 3 4 5 1.62 1.62 OLFM3 5.82 1.27 2.90 -0.95 -2.38 1 2 3 4 5 1.62 1.62 CADPS2 1.54 -0.74 0.88 -0.12 2.05 1 2 3 4 5 1.62 1.62 IGFBPL1 -0.42 -0.42 1.20 0.34 -0.29 1 2 3 4 5 1.62 1.62 HS.97584 0.25 -0.92 0.69 -0.07 0.99 1 2 3 4 5 1.62 1.62 MGC33407 -0.52 -1.02 0.60 -0.58 -0.33 1 2 3 4 5 1.62 1.62 HS.27608 0.07 0.87 2.48 -0.16 -0.18 1 2 3 4 5 1.62 1.62 LOC441344 -0.09 -0.36 1.26 0.36 -0.05 1 2 3 4 5 1.62 1.62 OR2V2 -0.48 -0.48 1.14 -0.32 0.35 1 2 3 4 5 1.61 1.61 HA02 -0.68 -0.54 1.08 0.36 -0.69 1 2 3 4 5 1.61 1.61 HRH4 -0.19 -0.13 1.48 -0.12 0.07 1 2 3 4 5 1.61 1.61 HES1 -0.64 -0.27 1.35 -0.74 -0.63 1 2 3 4 5 1.61 1.61 LOC388312 -0.13 0.66 2.27 -0.38 -0.05 1 2 3 4 5 1.61 1.61 KCND2 -1.92 -0.43 1.18 1.45 -0.31 1 2 3 4 5 1.61 1.61 HS.577797 0.19 -0.83 0.78 1.50 0.09 1 2 3 4 5 1.61 1.61 TMEM148 -0.21 -0.37 1.24 0.20 0.34 1 2 3 4 5 1.61 1.61 SLC24A5 -0.38 -1.34 0.27 -0.64 3.18 1 2 3 4 5 1.61 1.61 WNT9B -0.14 -0.77 0.84 1.28 -0.03 1 2 3 4 5 1.61 1.61 HS.566767 0.12 0.11 1.72 0.02 -0.39 1 2 3 4 5 1.61 1.61 PRDM13 0.95 -0.44 1.16 0.64 -0.25 1 2 3 4 5 1.61 1.61 GDA 1.33 -0.81 0.80 0.81 -0.44 1 2 3 4 5 1.61 1.61 RXFP4 -0.43 -0.46 1.14 0.90 -0.57 1 2 3 4 5 1.61 1.61 ZNF695 1.12 -0.71 0.90 -0.83 -0.47 1 2 3 4 5 1.61 1.61 HS.541914 -0.38 -0.18 1.43 -0.05 0.52 1 2 3 4 5 1.61 1.61 Table 3 HS.157803 0.14 -0.13 1.48 -0.26 -0.09 1 2 3 4 5 1.61 1.61 TMEM174 -0.24 -0.52 1.09 1.29 -0.21 1 2 3 4 5 1.61 1.61 HS.566251 -0.60 0.80 2.41 0.21 0.96 1 2 3 4 5 1.61 1.61 GSC -0.40 -0.49 1.12 -0.27 0.03 1 2 3 4 5 1.60 1.60 HS.434392 -0.25 -0.34 1.26 0.67 0.36 1 2 3 4 5 1.60 1.60 HS.565886 0.90 -0.22 1.38 0.19 1.23 1 2 3 4 5 1.60 1.60 HS.519810 0.57 -0.07 1.53 0.20 -0.05 1 2 3 4 5 1.60 1.60 HS.579318 0.41 -0.32 1.28 -0.13 -0.31 1 2 3 4 5 1.60 1.60 HS.303880 -0.82 -0.11 1.49 3.67 -0.74 1 2 3 4 5 1.60 1.60 FAM24A -0.52 -0.93 0.67 -1.91 -0.76 1 2 3 4 5 1.60 1.60 OR51G2 -0.99 -0.77 0.83 0.04 -0.30 1 2 3 4 5 1.60 1.60 HS.557245 -0.09 -0.13 1.48 -0.33 0.59 1 2 3 4 5 1.60 1.60 DAZL 2.51 -1.11 0.49 -0.38 -0.91 1 2 3 4 5 1.60 1.60 HPDL 0.85 -0.36 1.24 0.62 -0.31 1 2 3 4 5 1.60 1.60 LOC388948 -0.19 -0.21 1.39 0.83 0.34 1 2 3 4 5 1.60 1.60 HS.427926 -0.20 -0.40 1.20 0.12 -0.38 1 2 3 4 5 1.60 1.60 C210RF94 0.48 -0.60 1.00 -0.13 1.38 1 2 3 4 5 1.60 1.60 LOC440981 1.04 0.34 1.93 0.88 0.03 1 2 3 4 5 1.60 1.60 WFDC11 -0.64 -1.58 0.01 -0.57 -0.37 1 2 3 4 5 1.60 1.60 LOC644829 -0.18 -0.32 1.28 1.28 -0.14 1 2 3 4 5 1.60 1.60 EFCAB3 1.37; 0.17 1.77 -0.19 0.58 1 2 3 4 5 1.60 1.60 LOC653528 -0.64 -1.16 0.43 1.14 -0.14 1 2 3 4 5 1.60 1.60 PNLIPRP3 0.01 -0.21 1.39 4.79 -2.10 1 2 3 4 5 1.60 1.60 KC J1 4.13 1.70 3.30 0.57 -0.18 1 2 3 4 5 1.60 1.60 DLG5 -0.51 -0.38 1.21 0.44 -0.32 1 2 3 4 5 1.60 1.60 HS.546053 0.63: -0.91 0.68 -0.63 -0.01 1 2 3 4 5 1.60 1.60 HS.127847 0.03 0.13 1.73 0.58 -0.31 1 2 3 4 5 1.60 1.60 HS.564286 -1.19! -0.79 0.80 -0.88 -0.55 1 2 3 4 5 1.59 1.59 HS.565427 0.57 -0.85 0.74 -0.74 -0.60 1 2 3 4 5 1.59 1.59 HS.537864 0.19 -0.62 0.97 -0.36 -0.42 1 2 3 4 5 1.59 1.59 ZNF546 2.24 -0.55 1.04 -0.13 0.36 1 2 3 4 5 1.59 1.59 FA 83A -0.82 -0.44 1.15 0.51 -0.62 1 2 3 4 5 1.59 1.59 FU39743 -0.82 -0.03 1.56 -0.84 -0.22 1 2 3 4 5 1.59 1.59 ATP13A5 -0.80 -1.49 0.10 -0.55 2.65 1 2 3 4 5 1.59 1.59 OR2C3 0.53 -0.53 1.06 -1.07 -0.77 1 2 3 4 5 1.59 1.59 USHBP1 - -0.30 0.06 1.65 -0.41 -0.33 1 2 3 4 5 1.59 1.59 LOC647003 0.93 -0.07 1.52 0.06 0.62 1 2 3 4 5 1.59 1.59 C10RF125 0.72 -1.26 0.33 -0.75 5.45 1 2 3 4 5 1.59 1.59 KCNA7 -1.03 -0.99 0.59 -0.58 -0.47 1 2 3 4 5 1.59 1.59 HS.570192 1.81 0.21 1.80 -0.20 -0.64 1 2 3 4 5 . 1.59 1.59 GLRA3 -1.04 -0.83 0.75 -0.37 -0.37 1 2 3 4 5 1.59 1.59 HS.103355 -0.05 -0.77 0.81 0.23 -0.15 1 2 3 4 5 1.59 1.59 LOC652845 0.37 -0.15 1.44 -0.46 -0.52 1 2 3 4 5 1.58 1.58 LOC642302 -0.11 -0.54 1.04 0.21 -0.84 1 2 3 4 5 1.58 1.58 SIGLECll 0.65 -0.55 1.04 -0.29 -0.14 1 2 3 4 5 1.58 1.58 SLC7A2 4.84 -1.60 -0.02 0.40 1.91 1 2 3 4 5 1.58 1.58 HS.171487 0.47 -0.54 1.04 2.22 0.83 1 2 3 4 5 1.58 1.58 HS.122310 3.80 -0.36 1.22 -1.41 0.36 1 2 3 4 5 1.58 1.58 UM0DL1 -1.36 -0.83 0.75 -0.49 -0.72 1 2 3 4 5 1.58 1.58 Table 3 77 RLBP1 -0.22 0.00 1.58 -0.33 -0.21 1 2 3 4 5 1.58 1.58 F0LR1 -0.58 -0.88 0.70 0.94 0.06 1 2 3 4 5 1.58 1.58 TAS2R13 -0.08 -1.46 0.11 0.22 -0.95 1 2 3 4 5 1.58 1.58 HS.543731 -0.33 -0.16 1.42 0.60 -0.65 1 2 3 4 5 1.58 1.58 HS.569271 -0.91 -0.67 0.91 -0.05 -0.24 1 2 3 4 5 1.58 1.58 LOC728637 -0.14 0.24 1.82 -0.14 -0.07 1 2 3 4 5 1.58 1.58 HS.131541 0.03 3.27 4.85 -0.68 -0.95 1 2 3 4 5 1.58 1.58 HS.540234 -0.07 -0.09 1.49 -0.28 -0.16 1 2 3 4 5 1.58 1.58 HS.542148 -0.18 -0.13 1.45 0.13 -0.14 1 2 3 4 5 1.58 1.58 LOC442132 -0.20 -0.83 0.74 -0.07 -0.02 1 2 3 4 5 1.58 1.58 HS.566032 -0.16 0.65 2.23 -0.71 0.65 1 2 3 4 5 1.58 1.58 LOC652468 0.62 -0.72 0.86 1.69 2.83 1 2 3 4 5 1.58 1.58 HS.557454 1.30 -0.45 1.13 0.65 -0.23 1 2 3 4 5 1.58 1.58 ADCY1 -0.81 0.11 1.69 -0.28 0.23 1 2 3 4 5 1.58 1.58 HS.526574 2.61 2.50 4.07 0.41 0.67 1 2 3 4 5 1.58 1.58 HS.561461 1.02 0.40 1.97 0.50 2.98 1 2 3 4 5 1.58 1.58 VN1R4 -0.13 -0.43 1.14 -0.13 -0.34 1 2 3 4 5 1.57 1.57 HS.572243 0.35 -0.37 1.20 0.22 -0.14 1 2 3 4 5 1.57 1.57 LOC644976 -0.05 -0.37 1.21 -0.40 -0.35 1 2 3 4 5 1.57 1.57 LOC644489 2.19 0.67 2.25 -0.89 -0.78 1 2 3 4 5 1.57 1.57 DPP6 -0.41 -0.60 0.98 -0.46 -0.35 1 2 3 4 5 1.57 1.57 HS.197824 2.70 -0.49 1.09 1.10 1.29 1 2 3 4 5 1.57 1.57 C22ORF30 0.29 -0.33 1.24 0.06 -0.53 1 2 3 4 5 1.57 1.57 SNHG3 0.91 -0.38 1.19 3.32 -0.28 1 2 3 4 5 1.57 1.57 TRIM15 0.26 -0.72 0.85 0.53 -1.33 1 2 3 4 5 1.57 1.57 HS.540615 0.23 -0.02 1.55 0.58 -1.09 1 2 3 4 5 1.57 1.57 HS.60288 1.05 0.21 1.78 0.10 0.06 1 2 3 4 5 1.57 1.57 HIST1H1E -0.31 0.87 2.44 3.47 -1.13 1 2 3 4 5 1.57 1.57 CCKBR -0.99 -0.65 0.92 -0.50 -0.69 1 2 3 4 5 1.57 1.57 CSF2 -0.35 -0.38 1.19 -1.08 0.90 1 2 3 4 5 1.57 1.57 HS.546078 0.41 -0.86 0.72 0.99 0.33 1 2 3 4 5 1.57 1.57 LOC647540 -0.53 -0.35 1.22 1.87 -0.81 1 2 3 4 5 1.57 1.57 HS.552544 -0.71 -0.23 1.34 -1.11 1.04 1 2 3 4 5 1.57 1.57 HS.525530 -0.89 -1.03 0.54 0.08 -0.39 1 2 3 4 5 1.57 1.57 CCDC67 -0.93 -0.84 0.73 0.45 3.28 1 2 3 4 5 1.57 1.57 HS.543387 0.49 0.94 2.51 -0.09 -0.36 1 2 3 4 5 1.57 1.57 LOC650867 -0.65 -0.38 1.19 1.16 1.52 1 2 3 4 5 1.57 1.57 LOC442560 -0.36 0.25 1.82 1.19 0.81 1 2 3 4 5 1.57 1.57 MAGEB2 0.53 -0.42 1.15 -0.42 0.02 1 2 3 4 5 1.57 1.57 HS.158976 -0.24 -0.40 1.16 0.01 -0.38 1 2 3 4 5 1.56 1.56 OTOA -0.53 -0.52 1.04 0.77 -1.47 1 2 3 4 5 1.56 1.56 HS.576073 -0.35 -0.46 1.11' -0.32 -0.15 1 2 3 4 5 1.56 1.56 LOC401410 0.11 -0.93 0.63 0.19 -0.77 1 2 3 4 5 1.56 1.56 IL1RL1 0.46 1.09 2.65 -0.13 0.34 1 2 3 4 5 1.56 1.56 HS.573440 -0.03 -0.44 1.12 1.05 -0.31 1 2 3 4 5 1.56 1.56 LOC643006 1.00 -0.15 1.41 0.23 1.03 1 2 3 4 5 1.56 1.56 HS.523127 -0.25 -0.67 0.89 -0.11 -0.40 1 2 3 4 5 1.56 1.56 LOC727942 0.16 0.92 2.48 0.14 0.04 1 2 3 4 5 1.56 1.56 HS.567108 0.11 -0.66 0.90 0.00 -0.50 1 2 3 4 5 1.56 1.56 Table 3 78 HS.212235 -0.35 -0.59 0.97 -0.10 -0.04 1 2 3 4 5 1.56 1.56 HS.491071 2.66 -0.95 0.61 0.43 -0.85 1 2 3 4 5 1.56 1.56 LMX1A 2.66 0.01 1.57 -1.85 -0.71 1 2 3 4 5 1.56 1.56 SLC10A5 0.64 -1.57 -0.02 1.23 0.16 1 2 3 4 5 1.56 1.56 KLF16 -0.29 -0.57 0.98 -0.88 -0.38 1 2 3 4 5 1.56 1.56 C6 -0.08 0.28 1.84 1.75 1.08 1 2 3 4 5 1.55 1.55 HS.536449 -0.28 0.97 2.52 0.62 0.27 1 2 3 4 5 1.55 1.55 HS.201937 -0.28 -0.46 1.09 -0.38 -0.11 1 2 3 4 5 1.55 1.55 HS.575764 -0.48 -0.31 1.24 0.79 -0.26 1 2 3 4 5 1.55 1.55 HS.537796 -0.17 -0.28 1.26 -0.07 -0.01 1 2 3 4 5 1.55 1.55 LONRF2 -0.96 -0.30 1.25 0.89 -0.55 1 2 3 4 5 1.55 1.55 HS.555151 -0.36 -0.42 1.13 1.41 0.89 1 2 3 4 5 1.55 1.55 LOC730862 -0.32 0.07 1.62 2.54 0.55 1 2 3 4 5 1.55 1.55 HS.22347 -0.07 -0.10 1.45 -0.38 0.23 1 2 3 4 5 1.55 1.55 CARD14 -0.35 0.52 2.07 -0.76 0.52 1 2 3 4 5 1.55 1.55 SNCG -0.21 -1.26 0.29 0.31 -1.57 1 2 3 4 5 1.55 1.55 INSL4 -1.16 -0.84 0.71 -0.64 -0.60 1 2 3 4 5 1.55 1.55 HS.545461 -0.06 0.31 1.86 0.53 -0.47 1 2 3 4 5 1.55 1.55 AGXT2L1 0.78 0.00 1.54 -0.41 -0.31 1 2 3 4 5 1.54 1.54 HS.565882 0.17 -0.25 1.30 -0.04 0.94 1 2 3 4 5 1.54 1.54 HS.541754 4.52 0.12 1.66 1.12 0.71 1 2 3 4 5 1.54 1.54 HS.546768 -0.27 -0.23 1.31 -0.17 -0.03 1 2 3 4 5 1.54 1.54 HS.559746 -0.40 -0.77 0.78 0.06 0.64 1 2 3 4 5 1.54 1.54 LOC400221 -0.18 -0.68 0.86 -0.45 -0.83 1 2 3 4 5 1.54 1.54 HS.135421 -0.37 -0.17 1.37 -0.11 0.38 1 2 3 4 5 1.54 1.54 HS.580257 -0.69 -0.20 1.34 -0.86 0.37 1 2 3 4 5 1.54 1.54 ZNF619 0.62; -1.60 -0.06 0.01 -1.40 1 2 3 4 5 1.54 1.54 THRB -0.66 , -0.66 0.88 -0.60 -0.62 1 2 3 4 5 1.54 1.54 HS.471428 -0.03; 0.97 2.51 0.42 1.21 1 2 3 4 5 1.54 1.54 FAIM2 -0.56 -0.84 0.70 -0.68 -0.16 1 2 3 4 5 1.54 1.54 HS.434865 1.18 0.82 2.36 4.05 0.69 1 2 3 4 5 1.54 1.54 LOC642005 3.60 -0.16 1.38 2.41 0.29 1 2 3 4 5 1.54 1.54 ZNF610 0.26 0.86 2.40 2.13 -1.13 1 2 3 4 5 1.54 1.54 R0PN1 1.72 -0.15 1.39 -1.12 -0.63 1 2 3 4 5 1.54 1.54 LOC440233 1.91 -0.23 1.31 -1.02 0.34 1 2 3 4 5 1.54 1.54 HS.117067 0.16 0.23 1.77 -0.13 -0.05 1 2 3 4 5 1.54 1.54 KRT26 0.34 -0.45 1.08 -0.44 1.13 1 2 3 4 5 1.54 1.54 HS.550328 -0.28 1.00 2.54 -0.04 -0.75 1 2 3 4 5 1.54 1.54 LOC653715 0.89 -0.34 1.20 0.07 0.56 1 2 3 4 5 1.54 1.54 LOC645427 1.20 2.91 4.44 1.01 -0.23 1 2 3 4 5 1.54 1.54 LOC646439 -0.12 -0.04 1.49 -0.26 0.54 1 2 3 4 5 1.54 1.54 HS.433547 ' 1.21 -0.27 1.27 2.03 -1.05 1 2 3 4 5 1.54 1.54 HS.564261 -0.69 -0.25 1.29 0.96 -0.03 1 2 3 4 5 1.54 1.54 GJB5 -0.19 -1.04 0.49 -0.37 -0.87 1 2 3 4 5 1.54 1.54 C9ORF100 -0.39 -0.10 1.43 -0.27 -0.41 1 2 3 4 5 1.54 1.54 HS.560273 -0.15 -0.99 0.55 -0.34 0.82 1 2 3 4 5 1.53 1.53 KCNJ11 -0.05 0.53 2.06 0.06 -0.51 1 2 3 4 5 1.53 1.53 LOC648999 0.01 -1.56 -0.02 0.29 -1.23 1 2 3 4 5 1.53 1.53 DNAH12L 0.23 0.59 2.12 -0.54 1.80 1 2 3 4 5 1.53 1.53 Table 3 79 OR10A2 -0.88 0.74 2.27 -0.18 0.42 1 2 3 4 5 1.53 1.53 HS.560106 0.14 0.17 1.70 0.14 -0.16 1 2 3 4 5 1.53 1.53 HS.540149 2.88 0.34 1.87 -0.37 0.12 1 2 3 4 5 1.53 1.53 HS.539683 0.44 0.48 2.01 2.03 1.13 1 2 3 4 5 1.53 1.53 GRM7 -0.17 0.06 1.59 0.28 0.34 1 2 3 4 5 1.53 1.53 UGT1A10 -0.77 1.15 2.68 3.35 1.41 1 2 3 4 5 1.53 1.53 OXGR1 -0.20 -0.46 1.07 1.23 -0.20 1 2 3 4 5 1.53 1.53 C70RF52 -0.10 -0.42 1.11 0.01 -0.22 1 2 3 4 5 1.53 1.53 KRTAP4-7 -0.16 -0.23 1.30 -0.15 -0.32 1 2 3 4 5 1.53 1.53 LOC642856 -0.42 -0.19 1.34 -0.42 -0.29 1 2 3 4 5 1.53 1.53 HS.582332 -0.10 0.37 1.90 -1.37 -0.68 1 2 3 4 5 1.53 1.53 LOC390282 0.21 -1.00 0.53 -0.15 -0.44 1 2 3 4 5 1.53 1.53 TAS2R42 -0.80 -0.63 0.90 0.48 0.32 1 2 3 4 5 1.53 1.53 LOC651467 0.89 -0.90 0.62 0.00 0.69 1 2 3 4 5 1.53 1.53 HS.574688 0.15 -0.39 1.14 -0.17 0.37 1 2 3 4 5 1.53 1.53 HS.583877 0.52 -0.92 0.61 3.95 0.41 1 2 3 4 5 1.53 1.53 HS.570922 -0.32 -0.29 1.23 -0.35 -0.14 1 2 3 4 5 1.53 1.53 HS.434238 -0.42 -0.28 1.25 2.20 -0.01 1 2 3 4 5 1.53 1.53 PNPLA5 -0.02 0.14 1.66 -0.12 0.58 1 2 3 4 5 1.52 1.52 HS.570630 4.16 0.74 2.26 3.13 0.12 1 2 3 4 5 1.52 1.52 LOC646403 0.84 1.11 2.64 0.56 -0.47 1 2 3 4 5 1.52 1.52 SNCAIP -0.28 -0.70 0.82 -0.67 -0.39 1 2 3 4 5 1.52 1.52 DPP10 0.00 0.76 2.28 -0.63 -1.12 1 2 3 4 5 1.52 1.52 HS.564301 -0.21 -1.20 0.32 -0.94 0.11 1 2 3 4 5 1.52 1.52 LOC646050 1.17 -0.75 0.77 -0.35 -0.29 1 2 3 4 5 1.52 1.52 HS.334446 -0.23 -0.71 0.81 0.49 -0.64 1 2 3 4 5 1.52 1.52 HS.563768 1.07 0.28 1.80 1.41 0.11 1 2 3 4 5 1.52 1.52 LOC649908 0.07 -0.49 1.03 -0.13 1.15 1 2 3 4 5 1.52 1.52 LOC651721 -0.46 -1.04 0.48 -0.54 0.46 1 2 3 4 5 1.52 1.52 LOC389207 -0.52 -0.42 1.10 0.14 -0.89 1 2 3 4 5 1.52 1.52 HS.560658 0.91 -0.06 1.46 -0.77 0.45 1 2 3 4 5 1.52 1.52 HS.539581 2.05 -0.86 0.66 -0.62 -0.77 1 2 3 4 5 1.52 1.52 HS.570328 1.82 -0.06 1.46 -0.44 -0.53 1 2 3 4 5 1.52 1.52 HS.582596 -0.65 -0.55 0.97 -1.00 -0.63 1 2 3 4 5 1.52 1.52 HS.130432 -0.08 -0.16 1.35 -0.58 -0.45 1 2 3 4 5 1.52 1.52 HS.566123 1.40 0.46 1.98 -0.67 -0.51 1 2 3 4 5 1.52 1.52 PUNC -2.46 -1.44 0.07 -0.84 -0.19 1 2 3 4 5 1.51 1.51 HS.147579 -0.38 -0.38 1.13 0.63 -0.32 1 2 3 4 5 1.51 1.51 LOC391276 0.04 -0.21 1.30 1.07 0.23 1 2 3 4 5 1.51 1.51 ΤΤΤΎ18 1.60 -0.52 1.00 0.20 1.67 1 2 3 4 5 1.51 1.51 HS.545851 0.02 -0.53 0.98 1.39 -0.35 1 2 3 4 5 1.51 1.51 HS.576095 0.69 -0.51 1.00 1.79 -0.10 1 2 3 4 5 1.51 1.51 HS.128809 1.23 -0.27 1.24 1.18 0.23 1 2 3 4 5 1.51 1.51 LOC440402 1.03 -0.91 0.61 -0.55 -0.12 1 2 3 4 5 1.51 1.51 HS.523580 1.02 -0.54 0.97 0.28 -0.07 1 2 3 4 5 1.51 1.51 LOC642293 0.39 -1.05 0.46 0.57 -0.55 1 2 3 4 5 1.51 1.51 FU30851 1.02 -0.19 1.32 0.37 0.34 1 2 3 4 5 1.51 1.51 SSX1 -0.87 -0.90 0.61 2.26 0.24 1 2 3 4 5 1.51 1.51 LOC388181 0.24 -0.38 1.13 0.24 0.91 1 2 3 4 5 1.51 1.51 Table 3 80 LOC644431 0.25 -1.24 0.26 0.97 3.53 1 2 3 4 5 1.51 1.51 HS.101433 1.00 -1.07 0.43 -1.21 -0.51 1 2 3 4 5 1.51 1.51 HS.543452 -0.29 -0.15 1.35 -0.07 0.15 1 2 3 4 5 1.51 1.51 LOC650496 3.25 -0.32 1.18 1.36 -0.17 1 2 3 4 5 1.51 1.51 LOC643533 -0.42 -0.60 0.91 0.53 0.27 1 2 3 4 5 1.51 1.51 HS.542313 0.01 -0.04 1.46 -0.11 0.74 1 2 3 4 5 1.50 1.50 MACROD2 -0.54 0.53 2.03 -0.84 0.03 1 2 3 4 5 1.50 1.50 WASF1 -0.14 0.06 1.56 -0.45 0.49 1 2 3 4 5 1.50 1.50 LOC653412 -0.46 -1.23 0.28 2.44 3.49 1 2 3 4 5 1.50 1.50 SIX6 -0.32 -0.11 1.40 0.16 -1.11 1 2 3 4 5 1.50 1.50 HS.563249 0.14 -0.12 1.39 -0.14 0.27 1 2 3 4 5 1.50 1.50 RAB26 -0.15 0.31 1.82 0.09 0.14 1 2 3 4 5 1.50 1.50 HS.577657 0.41 -0.41 1.10 -0.83 -0.29 1 2 3 4 5 1.50 1.50 KIAA0802 -0.39 0.18 1.68 1.26 -0.05 1 2 3 4 5 1.50 1.50 C50RF36 -0.04 -0.47 1.03 0.75 1.67 1 2 3 4 5 1.50 1.50 HS.545120 -0.31 -0.17 1.33 1.14 -0.39 1 2 3 4 5 1.50 1.50 LOC645336 -0.24 -0.48 1.02 0.49 0.82 1 2 3 4 5 1.50 1.50 HS.382669 0.15 -0.50 1.00 -0.20 0.81 1 2 3 4 5 1.50 1.50 SLC9A2 -0.19 -0.40 1.10 0.05 -0.10 1 2 3 4 5 1.50 1.50 HS.575949 -0.30 0.06 1.56 -0.55 0.33 1 2 3 4 5 1.50 1.50 PTH -1.27 -1.35 0.15 0.31 -1.48 1 2 3 4 5 1.50 1.50 HS.544401 0.22 -0.80 0.70 -0.21 0.20 1 2 3 4 5 1.50 1.50 HS.578107 -0.16 -1.05 0.44 -0.89 1.02 1 2 3 4 5 1.50 1.50 LOC642490 -0.54: -0.44 1.06 0.25 0.86 1 2 3 4 1.50 1.50 HS.567118 -0.05 0.56 2.06 -0.26 -0.41 1 2 3 4 5 1.50 1.50 HS.565870 0.16 -0.74 0.76 0.20 -0.16 1 2 3 4 5 1.50 1.50 HS.561929 0.07 , -0.08 1.42 -0.03 0.42 1 2 3 4 5 1.50 1.50 RIBC2 1.93 -1.13 0.37 -0.03 -0.27 1 2 3 4 5 1.50 1.50 HS.439712 -0.41 -0.37 1.12 0.12 -0.06 1 2 3 4 5 1.49 1.49 HS.565107 -0.19 -0.39 1.10 -0.05 0.69 1 2 3 4 5 1.49 1.49 HS.575583 -0.21 -0.40 1.09 -0.05 -0.07 1 2 3 4 5 1.49 1.49 HS.560630 0.76 -0.89 0.60 2.12 -0.21 1 ' 2 3 4 5 1.49 1.49 HS.147849 4.64 -0.44 1.06 0.42 0.50 1 2 3 4 5 1.49 1.49 HS.308169 3.58 0.09 1.59 -0.59 0.01 1 2 3 4 5 1.49 1.49 LOC647786 0.59 -0.09 1.40 1.07 -0.19 1 2 3 4 5 1.49 1.49 LOC730804 5.86 0.39 1.88 -0.75 0.20 1 2 3 4 5 1.49 1.49 RNASE7 -0.01 -1.23 0.26 0.57 -0.58 1 2 3 4 5 1.49 1.49 LOC651576 -0.34 -0.15 1.35 -0.28 0.15 1 2 3 4 5 1.49 1.49 HS.543038 -0.12 -0.89 0.60 -0.43 4.09 1 2 3 4 5 1.49 1.49 LOC402110 -0.29 -0.22 1.27 1.99 0.30 1 2 3 4 5 1.49 1.49 LOC645363 -0.49 -0.76 0.73 -0.01 0.01 1 2 3 4 5 1.49 1.49 PALM2-AKAP2 -0.03 -1.11 0.38 0.54 -0.31 1 2 3 4 5 1.49 1.49 HS.577389 1.09 0.20 1.69 5.29 0.45 1 2 3 4 5 1.49 1.49 HS.128933 -0.63 0.28 1.77 0.10 0.49 1 2 3 4 5 1.49 1.49 DLL4 -0.49 -0.70 0.78 0.16 0.69 1 2 3 4 1.49 1.49 AVPR1B -0.26 -0.74 0.75 -0.50 -0.20 1 2 3 4 5 1.49 1.49 HS.541048 -0.62 -0.19 1.30 0.12 0.80 1 2 3 4 5 1.48 1.48 LOC402679 -0.42 0.11 1.60 1.35 1.08 1 2 3 4 5 1.48 1.48 LOC653878 -0.11 -0.33 1.15 -0.04 -0.06 1 2 3 4 5 1.48 1.48 Table 3 81 HS.196060 -0.24 -0.25 1.23 0.05 -0.55 1 2 3 4 5 1.48 1.48 LOC649293 -0.26 -0.49 0.99 0.82 0.17 1 2 3 4 5 1.48 1.48 LOC642939 -0.11 0.81 2.30 0.46 -0.70 1 2 3 4 5 1.48 1.48 LOC644377 -0.15 -0.31 1.17 -1.40 -0.43 1 2 3 4 5 1.48 1.48 HS.570713 1.49 -0.76 0.72 2.58 0.29 1 2 3 4 5 1.48 1.48 HS.566316 -0.12 0.78 2.26 1.18 -0.95 1 2 3 4 5 1.48 1.48 HS.303746 1.46 0.66 2.14 -0.54 3.17 1 2 3 4 5 1.48 1.48 HS.189824 4.49 -1.33 0.15 2.99 -1.37 1 2 3 4 5 1.48 1.48 PPP1R2P9 -0.59 -0.11 1.37 0.07 1.25 1 2 3 4 5 1.48 1.48 HS.545294 -0.12 -0.54 0.93 0.82 0.16 1 2 3 4 5 1.48 1.48 HS.42339 -0.29 -0.94 0.54 0.38 -0.26 1 2 3 4 5 1.48 1.48 LOC730656 -0.24 -0.04 1.44 0.69 -0.47 1 2 3 4 5 1.48 1.48 HS.539660 -0.23 -0.23 1.25 1.32 -0.58 1 2 3 4 5 1.48 1.48 AGPATI 0.29 -0.44 1.03 -0.20 -0.33 1 2 3 4 5 1.47 1.47 HS.558265 -0.05 -0.23 1.25 -0.07 0.18 1 2 3 4 5 1.47 1.47 HS.469353 -0.07 0.13 1.60 1.28 1.64 1 2 3 4 5 1.47 1.47 HS.554311 -0.51 -0.52 0.95 -0.44 0.75 1 2 3 4 5 1.47 1.47 HS.545349 -0.09 -0.77 0.70 -0.27 0.13 1 2 3 4 5 1.47 1.47 HS.129345 -0.35 -0.22 1.25 -0.24 -0.02 1 2 3 4 5 1.47 1.47 HS.126962 0.09 0.07 1.54 4.71 -1.77 1 2 3 4 5 1.47 1.47 HS.477344 1.66 -0.35 1.12 1.10 0.41 1 2 3 4 5 1.47 1.47 TSPAN8 -0.22 -0.78 0.69 1.28 -0.60 1 2 3 4 5 1.47 1.47 GPR161 -0.45 -0.79 0.68 -0.34 -0.64 1 2 3 4 5 1.47 1.47 DLK1 1.83 0.07 1.54 -0.23 0.08 1 2 3 4 5 1.47 1.47 HS.562812 -0.55 -0.71 0.76 1.91 -0.40 1 2 3 4 5 1.47 1.47 LOC441799 1.00 0.32 1.79 -0.46 0.40 1 2 3 4 5 1.47 1.47 HS.150022 -0.68 -0.80 0.67 0.13 -0.75 1 2 3 4 5 1.47 1.47 TAGLN3 1.37 -0.86 0.61 1.54 -0.55 1 2 3 4 5 1.47 1.47 HS.580670 3.04 -0.83 0.63 1.71 0.25 1 2 3 4 5 1.47 1.47 LOC648460 0.35 -0.15 1.32 -0.07 0.13 1 2 3 4 5 1.47 1.47 LOC152586 -0.29 -0.54 0.93 0.04 -0.12 1 2 3 4 5 1.47 1.47 LOC643468 -0.37 -0.17 1.29 -1.04 -0.83 1 2 3 4 5 1.47 1.47 HS.566652 0.36 0.48 1.95 0.17 -0.70 1 2 3 4 5 1.47 1.47 HS.223225 0.06 -0.60 0.86 -0.92 -1.04 1 2 3 4 5 1.47 1.47 HS.577894 -0.36 0.29 1.76 0.67 -0.83 1 2 3 4 5 1.47 1.47 HS.149150 -0.48 0.04 1.51 0.36 0.47 1 2 3 4 5 1.47 1.47 IRX5 3.63 -0.16 1.31 -0.30 3.38 1 2 3 4 5 1.46 1.46 LOC641721 1.03 -0.17 1.30 0.70 0.16 1 2 3 4 5 1.46 1.46 OR7E91P -0.54 -0.15 1.31 -0.62 0.88 1 2 3 4 5 1.46 1.46 HS.570910 1.05 -0.71 0.75 0.11 -1.00 1 2 3 4 5 1.46 1.46 LOC650459 -0.43 2.19 3.65 1.01 1.38 1 2 3 4 5 1.46 1.46 - HS.539851 0.24 -0.07 1.39 -0.36 1.22 1 2 3 4 5 1.46 1.46 HS.543410 0.71 0.35 1.81 2.68 -0.55 1 2 3 4 5 1.46 1.46 HS.436447 -0.66 -0.11 1.35 -0.59 -0.84 1 2 3 4 5 1.46 1.46 HS.537912 0.54 0.64 2.10 0.12 0.05 1 2 3 4 5 1.46 1.46 vex -0.62 -1.70 -0.24 -1.08 -0.16 1 2 3 4 5 1.46 1.46 LOC646190 0.49 -0.62 0.84 -1.31 -0.55 1 2 3 4 5 1.46 1.46 LOC653499 3.10 -0.18 1.28 0.95 0.43 1 2 3 4 1.46 1.46 0R4S1 -0.65 -0.30 1.16 0.17 0.28 1 2 3 4 5 1.46 1.46 Table 3 82 LOC647566 -0.28 -0.26 1.20 0.72 -0.66 1 2 3 4 5 1.46 1.46 HS.581869 -0.70 1.37 2.83 -0.23 -0.90 1 2 3 4 5 1.46 1.46 LOC728185 3.63 -1.31 0.14 0.98 2.41 1 2 3 4 5 1.46 1.46 HS.224279 1.05; -0.42 1.04 1.37 0.84 1 2 3 4 5 1.46 1.46 HS.548217 -0.37 0.05 1.51 0.29 0.02 1 2 3 4 1.46 1.46 LOC731408 0.08 -0.54 0.92 -0.53 0.13 1 2 3 4 5 1.46 1.46 LOC646194 -0.17 -1.24 0.21 1.03 0.33 1 2 3 4 5 1.46 1.46 OPN4 -0.37 1.15 2.61 0.66 -0.11 1 2 3 4 5 1.45 1.45 LOC643813 -0.16 0.26 1.71 -0.20 0.08 1 2 3 4 5 1.45 1.45 GPR148 -0.34 -0.46 0.99 2.24 0.18 1 2 3 4 5 1.45 1.45 HS.71999 -0.05 -0.21 1.24 -0.14 -0.09 1 2 3 4 5 1.45 1.45 HS.543360 0.19 -0.62 0.84 -0.20 0.44 1 2 3 4 5 1.45 1.45 KLF14 2.59 -0.55 0.90 -0.78 1.55 1 2 3 4 5 1.45 1.45 HR -1.33 -1.09 0.36 -0.52 -0.47 1 2 3 4 5 1.45 1.45 LOC653574 0.30 0.50 1.96 1.87 1.59 1 2 3 4 5 1.45 1.45 SYCN 0.27 -0.16 1.30 -0.63 0.40 1 2 3 4 5 1.45 1.45 HS.124584 -0.45 -0.60 0.85 -0.19 -0.39 1 2 3 4 5 1.45 1.45 HS.539181 -0.17 0.34 1.79 1.49 0.23 1 2 3 4 5 1.45 1.45 LOC645777 0.94 -0.43 1.02 0.98 1.00 1 2 3 4 5 1.45 1.45 CPA2 -1.12 -0.27 1.18 1.77 0.78 1 2 3 4 5 1.45 1.45 FU32252 -0.11; -0.11 1.35 1.63 0.59 1 2 3 4 5 1.45 1.45 HS.573860 2.03 0.10 1.56 1.13 3.52 1 2 3 4 5 1.45 1.45 VTCN1 i.io| -0.40 1.05 3.18 1.13 1 2 3 4 5 1.45 1.45 HS.570326 1.89 0.92 2.37 -0.47 -0.42 1 2 3 4 5 1.45 1.45 PAIP2B -0.17 -0.25 1.20 -0.21 -0.26 1 2 3 4 5 1.45 1.45 HS.565636 -0.05 -0.66 0.79 3.60 0.99 1 2 3 4 5 1.45 1.45 HS.536103 -0.01 -0.52 0.93 0.04 -0.53 1 2 3 4 5 1.45 1.45 HS.136495 0.87 -0.34 1.10 -0.07 5.10 1 2 3 4 5 1.45 1.45 FU23172 -1.02 -0.86 0.59 4.87 -0.82 1 2 3 4 1.45 1.45 OR52E4 -0.40: -0.52 0.93 -0.20 -0.57 1 2 3 4 5 1.45 1.45 DCST2 -0.11 -1.30 0.15 0.34 -2.23 1 2 3 4 5 1.45 1.45 HS.576651 -0.45 -0.65 0.80 -0.15 -0.61 1 2 3 4 5 1.45 1.45 TSPAN19 0.02 -0.53 0.91 0.30 0.42 1 2 3 4 5 1.45 1.45 HS.38546 0.06 -0.03 1.42 0.00 -0.25 1 2 3 4 5 1.44 1.44 OR4A5 -0.80 0.06 1.50 1.65 -1.02 1 2 3 4 5 1.44 1.44 HS.579062 -0.60 -0.59 0.85 0.29 -0.29 1 2 3 4 5 1.44 1.44 DLGAP3 -0.51 -0.76 0.68 2.85 -0.84 1 2 3 4 5 1.44 1.44 KLHL30 -0.60 -0.46 0.98 -0.16 0.71 1 2 3 4 5 1.44 1.44 BAAT 1.44 0.18 1.63 -1.82 -1.79 1 2 3 4 5 1.44 1.44 HS.116928 -0.30 0.03 1.48 1.24 0.50 1 2 3 4 5 1.44 1.44 HS.562041 -0.61 -0.57 0.87 0.07 3.34 1 2 3 4 5 1.44 1.44 HS.537601 -0.75 -1.02 0.42 -0.91 -0.53 1 2 3 4 5 1.44 1.44 HS.112970 -0.01 -0.70 0.74 0.67 0.50 1 2 3 4 5 1.44 1.44 C60RF114 -0.76 -0.95 0.49 -0.78 0.38 1 2 3 4 5 1.44 1.44 HS.521975 -0.55 -0.30 1.14 -0.12 -0.19 1 2 3 4 5 1.44 1.44 LOC643850 0.14 1.09 2.53 0.83 -0.21 1 2 3 4 5 1.44 1.44 HS.188767 -0.50 -0.41 1.03 -0.04 -0.53 1 2 3 4 5 1.44 1.44 HS.574010 -0.03 -1.15 0.29 0.97 -1.05 1 2 3 4 5 1.44 1.44 LOC440910 -0.26 0.75 2.19 0.23 0.51 1 2 3 4 5 1.44 1.44 Table 3 HS.435284 1.02 -0.48 0.96 0.36 1.68 1 2 3 4 5 1.44 1.44 KANK2 -0.41 0.70 2.14 -0.33 3.43 1 2 3 4 5 1.44 1.44 HS.570875 -0.40 -0.33 1.11 -0.36 0.21 1 2 3 4 5 1.44 1.44 HS.523235 -0.09 -0.16 1.28 0.30 0.18 1 2 3 4 5 1.44 1.44 LOC492303 1.43 -0.09 1.35 0.71 -1.40 1 2 3 4 5 1.44 1.44 HS.537510 -0.07 -0.30 1.14 0.73 0.02 1 2 3 4 1.44 1.44 HS.539119 0.50 -0.04 1.40 0.08 -0.08 1 2 3 4 5 1.44 1.44 RBMXL2 -1.57 0.13 1.57 1.63 0.20 1 2 3 4 5 1.44 1.44 LOC645783 -0.39 -0.31 1.12 -0.90 0.17 1 2 3 4 5 1.43 1.43 HS.525223 -0.90 0.19 1.62 2.08 0.58 1 2 3 4 5 1.43 1.43 HS.561822 1.18 -0.86 0.57 -0.40 0.80 1 2 3 4 5 1.43 1.43 HS.568740 -0.29 -0.46 0.98 -0.39 -0.06 1 2 3 4 5 1.43 1.43 LOC732381 0.49 -0.21 1.22 -0.09 -0.15 1 2 3 4 5 1.43 1.43 HS.159745 -0.88 -1.09 0.34 -0.87 0.82 1 2 3 4 5 1.43 1.43 EPHA6 0.03 0.23 1.66 -0.26 -0.49 1 2 3 4 5 1.43 1.43 ZNF547 -1.03 -1.15 0.28 -1.14 -1.58 1 2 3 4 5 1.43 1.43 HS.554416 0.22 0.07 1.50 0.30 -0.13 1 2 3 4 5 1.43 1.43 OCA2 -0.17 -0.56 0.87 -0.46 3.87 1 2 3 4 5 1.43 1.43 HS.565565 0.55 -0.54 0.89 1.46 -0.94 1 2 3 4 5 1.43 1.43 HS.319299 -0.36 0.18 1.61 0.18 -0.14 1 2 3 4 5 1.43 1.43 LOC652499 -0.13 -1.12 0.31 0.68 0.09 1 2 3 4 5 1.43 1.43 HS.540128 2.16 -0.83 0.60 0.30 0.60 1 2 3 4 5 1.43 1.43 HS.563775 2.21 -0.61 0.82 3.28 -0.32 1 2 3 4 5 1.43 1.43 LOC649385 0.16 -0.01 1.42 -0.20 -0.06 1 2 3 4 5 1.43 1.43 HS.545114 -0.13 0.00 1.42 -0.16 1.75 1 2 3 4 5 1.42 1.42 HS.546150 0.92 1.03 2.45 0.42 0.11 1 2 3 4 5 1.42 1.42 ELA3A -0.23 0.31 1.73 0.47 0.48 1 2 3 4 5 1.42 1.42 HS.26016 -0.43 -0.16 1.26 -0.24 0.55 1 2 3 4 5 1.42 1.42 KIAA1239 -0.54 -0.79 0.63 0.02 -0.22 1 2 3 4 5 1.42 1.42 HS.222909 -0.32 0.29 1.71 -0.09 0.07 1 2 3 4 5 1.42 1.42 ORM1 0.10 -0.05 1.37 -0.46 0.53 1 2 3 4 5 1.42 1.42 BPIL2 -0.97 -0.37 1.05 1.84 0.00 1 2 3 4 5 1.42 1.42 OR4C13 -0.50 0.17 1.59 -0.42 -0.39 1 2 3 4 5 1.42 1.42 KRT82 -0.44 -0.47 0.95 -0.63 0.02 1 2 3 4 5 1.42 1.42 FU46210 1.14 -0.02 1.40 0.30 0.15 1 2 3 4 5 1.42 1.42 PSKH2 0.20 -1.71 -0.29 -0.92 -1.02 1 2 3 4 5 1.42 1.42 HS.237007 0.84 -0.67 0.75 0.80 0.78 1 2 3 4 5 1.42 1.42 C3ORF20 -1.07 -0.66 0.76 0.71 0.93 1 2 3 4 5 1.42 1.42 KRTAP22-1 -0.35 -0.70 0.72 -0.36 -0.85 1 2 3 4 5 1.42 1.42 HS.573554 -0.56 -0.16 1.26 -0.27 0.67 1 2 3 4 5 1.42 1.42 MAGEB3 -0.41 -0.48 0.94 -0.07 -0.21 1 2 3 4 5 1.42 1.42 OR1I1 1.69 -1.01 0.41 2.81 3.60 1 2 3 4 5 1.42 1Λ 2 HS.565260 -0.45 -0.40 1.01 1.17 0.07 1 2 3 4 5 1.42 1.42 TRAM1L1 0.34 -0.21 1.21 -0.40 -0.08 1 2 3 4 5 1.41 1.41 FU43987 0.20 0.01 1.42 -0.41 0.43 1 2 3 4 5 1.41 1.41 HS.291680 0.63 1.24 2.66 -0.50 1.51 1 2 3 4 5 1.41 1.41 MGC24125 0.46 -0.04 1.37 -0.05 1.03 1 2 3 4 5 1.41 1.41 LHX9 -0.63 1.45 2.87 1.73 0.14 1 2 3 4 5 1.41 1.41 LOC651655 4.27 -1.16 0.26 2.17 2.93 1 2 3 4 5 1.41 1.41 Table 3 84 LOC643717 0.48 0.52 1.93 0.15 0.17 1 2 3 4 5 1.41 1.41 TSPAN7 -0.12 -0.84 0.57 -0.49 -1.42 1 2 3 4 5 1.41 1.41 HS.407537 0.50 0.13 1.55 -0.77 -0.40 1 2 3 4 5 1.41 1.41 LOC646918 -0.67 -0.63 0.78 -0.44 -1.27 1 2 3 4 5 1.41 1.41 HS.565405 0.63 -0.08 1.33 -0.13 -0.11 1 2 3 4 5 1.41 1.41 HS.538184 -1.40 0.47 1.88 0.62 -0.60 1 2 3 4 5 1.41 1.41 HS.581454 -0.44 -0.42 0.99 -0.24 -0.15 1 2 3 4 5 1.41 1.41 LOC402508 -0.16 -0.40 1.01 0.28 0.15 1 2 3 4 5 1.41 1.41 HS.559599 0.05 -0.34 1.07 0.85 0.94 1 2 3 4 5 1.41 1.41 LOC645645 0.83 -1.56 -0.15 3.15 1.98 1 2 3 4 5 1.41 1.41 HS.334272 -0.01 0.02 1.43 -0.11 -0.15 1 2 3 4 5 1.41 1.41 FAM75A1 0.17 0.26 1.67 1.76 1.95 1 2 3 4 5 1.41 1.41 HS.538380 0.01 0.30 1.71 -0.46 -0.02 1 2 3 4 5 1.41 1.41 GLP2R 0.73 -0.33 1.08 1.29 -0.89 1 2 3 4 5 1.41 1.41 GRIK4 3.30 -0.86 0.54 0.53 0.84 1 2 3 4 5 1.41 1.41 DUX5 -0.56 -1.09 0.31 -0.73 1.28 1 2 3 4 5 1.41 1.41 HS.564082 0.37 -0.14 1.27 -0.43 0.66 1 2 3 4 5 1.41 1.41 TGM5 2.37 0.12 1.52 -1.07 0.17 1 2 3 4 5 1.41 1.41 EBF3 1.70 -0.50 0.90 0.28 -0.01 1 2 3 4 5 1.40 1.40 HS.566474 -0.77 -0.76 0.64 0.44 -0.26 1 2 3 4 5 1.40 1.40 HS.540398 -0.76 -0.84 0.56 0.61 -0.42 1 2 3 4 5 1.40 1.40 HS.541113 0.59 -0.56 0.84 -0.80 0.62 1 2 3 4 5 1.40 1.40 HS.538577 0.93 -0.44 0.96 1.27 0.20 1 2 3 4 5 1.40 1.40 HS.563808 0.12 -1.28 0.12 1.11 0.08 1 2 3 4 5 1.40 1.40 HS.572272 -0.10 0.09 1.50 0.73 0.78 1 2 3 4 5 1.40 1.40 HCG3 -0.33 -0.77 0.64 -0.37 -0.53 1 2 3 4 5 1.40 1.40 LOC651073 -0.17 -0.13 1.27 -0.06 0.00 1 2 3 4 5 1.40 1.40 LOC649723 -0.73 -1.04 0.36 0.86 0.01 1 2 3 4 5 1.40 1.40 ARR3 -0.57 -0.43 0.97 0.20 -0.76 1 2 3 4 5 1.40 1.40 PSG8 -0.40 -0.19 1.21 0.08 0.38 1 2 3 4 5 1.40 1.40 HS.572225 -0.38 -0.80 0.60 0.06 -0.34 1 2 3 4 5 1.40 1.40 ADAMTS7 -1.31 -0.83 0.57 0.03 1.10 1 2 3 4 5 1.40 1.40 HS.379473 -0.52 -0.53 0.87 1.70 2.92 1 2 3 4 5 1.40 1.40 MGC48628 -0.33 -0.41 0.99 1.90 -0.08 1 2 3 4 5 1.40 1.40 HS.546005 -0.98 -0.65 0.75 2.37 -0.59 1 2 3 4 5 1.40 1.40 HS.197597 -0.15 -0.09 1.31 1.42 0.59 1 2 3 4 5 1.40 1.40 HS.582144 -0.17 -0.16 1.23 3.18 -0.29 1 2 3 4 5 1.40 1.40 LRRC52 -1.11 0.03 1.42 2.75 -0.31 1 2 3 4 5 1.40 1.40 PCDHGA5 2.52 -1.07 0.32 -1.76 0.38 1 2 3 4 5 1.40 1.40 LOC442519 0.36 0.11 1.51 0.29 0.59 1 2 3 4 5 1.40 1.40 FBXL2 6.18 0.72 2.11 1.44 0.86 1 2 3 4 5 1.40 1.40 HS.407028 -0.47 -0.41 0.98 1.32 2.44 1 2 3 4 5 1.40 1.40 HS.540318 -0.70 -0.06 1.33 0.10 -0.35 1 2 3 4 5 1.39 1.39 STC2 1.36 -1.81 -0.42 -0.32 -0.55 1 2 3 4 5 1.39 1.39 HS.161173 0.05 -0.17 1.23 3.42 0.28 1 2 3 4 5 1.39 1.39 ID4 0.70 -2.43 -1.03 -3.18 -2.43 1 2 3 4 5 1.39 1.39 HS.566393 -0.11 -0.08 1.31 -0.39 -0.08 1 2 3 4 5 1.39 1.39 HS.544254 2.08 1.12 2.51 0.15 0.31 1 2 3 4 5 1.39 1.39 COX6A2 1.04 0.24 1.63 -0.56 0.85 1 2 3 4 5 1.39 1.39 Table 3 85 LOC649103 2.58 0.15 1.54 2.31 0.56 1 2 3 4 5 1.39 1.39 HS.493928 -0.33 0.15 1.54 -0.39 0.05 1 2 3 4 5 1.39 1.39 HS.537778 -0.68 -0.51 0.88 0.61 0.62 1 2 3 4 5 1.39 1.39 HS.563322 -0.01 0.95 2.34 -0.31 1.38 1 2 3 4 5 1.39 1.39 HS.539302 -0.08 0.91 2.30 0.03 0.82 1 2 3 4 5 1.39 1.39 HS.581224 -0.56 -0.39 1.00 1.34 0.27 1 2 3 4 5 1.39 1.39 ZFP41 -0.34 -0.06 1.33 0.38 0.20 1 2 3 4 5 1.39 1.39 HS.122387 -0.34 -0.28 1.11 0.21 -0.23 1 2 3 4 5 1.39 1.39 HS.575519 0.24 -0.19 1.20 1.66 0.13 1 2 3 4 5 1.39 1.39 SCUBE3 2.95 0.60 1.98 -0.16 0.00 1 2 3 4 5 1.39 1.39 HS.577763 0.00 -0.03 1.35 -0.27 -0.12 1 2 3 4 5 1.39 1.39 KIAA1549 1.05 -0.41 0.97 0.31 -0.50 1 2 3 4 5 1.39 1.39 MMRN2 -0.56 -0.62 0.77 0.00 -0.49 1 2 3 4 5 1.39 1.39 LCE1A 0.00 -0.09 1.29 1.08 0.00 1 2 3 4 5 1.38 1.38 HS.544012 -0.57 -1.06 0.33 -0.36 1.59 1 2 3 4 5 1.38 1.38 HS.574014 -0.07 -0.53 0.85 0.71 0.16 1 2 3 4 5 1.38 1.38 LOC654109 -0.42 -0.92 0.46 -0.23 -0.86 1 2 3 4 5 1.38 1.38 PR0KR1 0.17 -1.74 -0.36 -1.65 -1.10 1 2 3 4 5 1.38 1.38 HS.545164 -0.24 0.45 1.83 -0.18 -0.48 1 2 3 4 5 1.38 1.38 TPTE2 -1.14 1.26 2.64 0.13 1.29 1 2 3 4 5 1.38 1.38 KRTAP19-4 -0.61 -0.03 1.35 0.22 -0.08 1 2 3 4 5 1.38 1.38 ACOT6 1.63 0.07 1.45 -0.57 -0.07 1 2 3 4 5 1.38 1.38 OR52K2 -0.18 0.01 1.39 0.37 -0.15 1 2 3 4 5 1.38 1.38 LOC619207 1.47 0.01 1.38 0.26 -0.20 1 2 3 4 5 1.38 1.38 LOC653397 3.12 -0.19 1.19 2.51 -0.35 1 2 3 4 5 1.38 1.38 CPLX2 -0.31 -0.42 0.95 0.01 -0.39 1 2 3 4 5 1.38 1.38 RPE65 -1.77, -0.76 0.62 0.91 -1.41 1 2 3 4 5 1.38 1.38 HS.415131 0.60 -0.34 1.03 -0.23 0.49 1 2 3 4 5 1.37 1.37 UNC93A -0.11 -0.07 1.31 0.73 -0.15 1 2 3 4 5 1.37 1.37 HS.490195 -0.30 -0.37 1.00 0.20 0.35 1 2 3 4 1.37 1.37 HS.134962 -0.02 -0.29 1.09 0.16 -0.57 1 2 3 4 5 1.37 1.37 OR6C70 0.64 -0.23 1.15 0.20 3.05 1 2 3 4 5 1.37 1.37 HS.553445 1.61 -0.32 1.05 0.55 0.33 1 2 3 4 5 1.37 1.37 HS.557040 -0.37 -0.37 1.01 -0.20 -0.24 1 2 3 4 5 1.37 1.37 HS.571630 1.43 0.44 1.81 -0.13 0.32 1 2 3 4 5 1.37 1.37 HS.575834 1.72 -0.82 0.55 1.64 3.06 1 2 3 4 5 1.37 1.37 HS.70723 2.35 -1.16 0.21 0.68 1.06 1 2 3 4 5 1.37 1.37 LOC647509 -0.11 0.25 1.63 0.93 0.36 1 2 3 4 5 1.37 1.37 TAOK3 0.14 -0.72 0.65 2.86 0.67 1 2 3 4 5 1.37 1.37 HS.136684 1.91 0.07 1.44 3.33 1.06 1 2 3 4 5 1.37 1.37 HS.571090 0.36 0.01 1.38 -0.11 0.82 1 2 3 4 1.37 1.37 LOC440087 0.92 -1.23 0.13 0.02 -0.78 1 2 3 4 5 1.37 1.37 HS.543116 -0.69 0.55 1.92 -1.37 -1.09 1 2 3 4 5 1.37 1.37 IL24 -0.26 -0.37 1.00 -0.55 -0.55 1 2 3 4 5 1.37 1.37 C10ORF79 0.59 -0.60 0.77 -0.35 1.02 1 2 3 4 5 1.37 1.37 HS.143075 -0.60 0.87 2.24 -0.56 -1.24 1 2 3 4 5 1.37 1.37 FU46284 -0.28 -0.24 1.13 -0.39 -0.31 1 2 3 4 5 ; 1.37 1.37 HS.550168 -0.71 2.03 3.39 -0.29 -0.25 1 2 3 4 5 1.37 1.37 HS.580955 -0.79 -1.14 0.22 -0.74 -0.14 1 2 3 4 5 1.37 1.37 Table 3 86 HS.453381 1.65 0.37 1.74 -0.29 -0.20 1 2 3 4 5 1.37 1.37 HS.574015 -1.19 -0.55 0.82 0.02 -3.26 1 2 3 4 5 1.37 1.37 HELT -0.25 -0.16 1.20 0.82 -0.01 1 2 3 4 5 1.37 1.37 HS.566957 -0.47 -0.79 0.57 -0.07 2.05 1 2 3 4 5 1.36 1.36 LOC652179 -0.22 -0.28 1.09 0.33 -0.14 1 2 3 4 5 1.36 1.36 HS.539245 -0.59 -0.29 1.08 -0.34 0.11 1 2 3 4 5 1.36 1.36 HS.564613 1.00 -0.42 0.94 -0.36 -0.23 1 2 3 4 5 1.36 1.36 LOC442582 -0.06 -0.20 1.16 -0.12 -0.10 1 2 3 4 5 1.36 1.36 EML1 -0.58 -0.99 0.37 0.00 1.48 1 2 3 4 5 1.36 1.36 HS.539915 -0.40 -0.41 0.95 0.32 -0.23 1 2 3 4 5 1.36 1.36 CCDC150 0.36 -0.56 0.80 -0.05 -0.05 1 2 3 4 5 1.36 1.36 C20ORF166 0.57 0.46 1.82 0.28 1.13 1 2 3 4 5 1.36 1.36 HS.553351 -0.26 -0.40 0.96 0.53 -0.24 1 2 3 4 5 1.36 1.36 0R5A1 0.47 -0.42 0.94 -0.22 2.75 1 2 3 4 5 1.36 1.36 HS.550272 -0.27 0.40 1.76 0.19 -0.47 1 2 3 4 5 1.36 1.36 LOC339524 -0.31 0.08 1.44 0.06 0.11 1 2 3 4 5 1.36 1.36 GLYAT 1.23 0.19 1.55 -0.20 -0.20 1 2 3 4 5 1.36 1.36 LRRC27 -0.80 -0.76 0.59 1.57 -0.50 1 2 3 4 5 1.36 1.36 HS.543970 -0.37 -0.25 1.11 0.07 -0.21 1 2 3 4 5 1.36 1.36 HS.19985 -0.31 -0.14 1.21 -0.22 -0.33 1 2 3 4 5 1.36 1.36 HS.522673 1.32 0.51 1.87 -0.45 1.41 1 2 3 4 5 1.35 1.35 HS.438985 3.42 0.30 1.66 1.54 0.39 1 2 3 4 5 1.35 1.35 ETV3L 0.88 -0.33 1.02 -0.29 -0.99 1 2 3 4 5 1.35 1.35 LOC644167 0.15 0.50 1.85 -0.07 0.48 1 2 3 4 5 1.35 1.35 GABRA1 -0.22 -0.32 1.03 0.02 1.04 1 2 3 4 5 1.35 1.35 0T0P2 -0.02 -0.42 0.93 -0.66 -1.43 1 2 3 4 5 1.35 1.35 MIXL1 0.42 -0.11 1.25 2.72 -1.14 1 2 3 4 5 1.35 1.35 GRIN2A -0.31 -0.28 1.08 -0.18 -0.44 1 2 3 4 5 1.35 1.35 OR8I2 2.98 1.11 2.46 -1.13 -0.60 1 2 3 4 5 1.35 1.35 VGLL2 -0.34 -0.15 1.21 -0.17 -0.38 1 2 3 4 5 1.35 1.35 HS.577060 0.20 -0.69 0.66 -1.20 0.21 1 2 3 4 5 1.35 1.35 HS.308615 1.17 -0.07 1.28 -0.43 0.04 1 2 3 4 5 1.35 1.35 HS.278265 -0.14 -0.28 1.08 0.08 0.27 1 2 3 4 5 1.35 1.35 NKX2-2 -0.07 -0.06 1.29 -0.18 -0.39 1 2 3 4 5 1.35 1.35 LCE1E 1.58 -1.13 0.22 -0.26 -0.62 1 2 3 4 5 1.35 1.35 HS.132486 1.82 -0.03 1.32 0.21 -0.17 1 2 3 4 5 1.35 1.35 HS.116531 -0.61 -0.77 0.58 2.35 1.04 1 2 3 4 5 1.35 1.35 OR52E5 -0.33 0.97 2.32 -0.24 -0.10 1 2 3 4 5 1.35 1.35 HS.540082 0.88 -1.21 0.14 2.63 0.11 1 2 3 4 5 1.35 1.35 IGSF3 -0.75 -1.63 -0.28 -0.49 -1.26 1 2 3 4 5 1.35 1.35 OR10W1 0.12 0.03 1.38 0.59 0.81 1 2 3 4 5 1.35 1.35 HS.541821 0.89 -0.86 0.48 4.45 0.88 1 2 3 4 5 1.35 1.35 HS.569406 0.23 0.08 1.43 0.49 -0.44 1 2 3 4 5 1.35 1.35 HS.476854 -0.85 -0.08 1.27 4.87 4.37 1 2 3 4 5 1.35 1.35 HS.247868 0.58 -0.35 1.00 0.99 0.04 1 2 3 4 5 1.35 1.35 HS.478583 2.46 0.00 1.35 -1.01 0.29 1 2 3 4 5 1.35 1.35 HS.538695 -0.37 -0.28 1.07 0.28 1.09 1 2 3 4 5 1.35 1.35 LOC649199 -0.49 0.32 1.66 -0.17 0.23 1 2 3 4 5 1.35 1.35 CYP3A43 0.33 -0.60 0.74 0.03 1.61 1 2 3 4 5 1.34 1.34 Table 3 87 EXOD1 -0.22 -0.01 1.33 -0.55 -0.42 1 2 3 4 5 1.34 1.34 HS.526996 0.59 -0.43 0.92 -0.70 -1.02 1 2 3 4 5 1.34 1.34 DBF4B -0.51 -0.24 1.10 0.08 -0.04 1 2 3 4 5 1.34 1.34 HS.127678 -0.53 -0.22 1.12 -0.67 -0.31 1 2 3 4 5 1.34 1.34 LOC653563 0.69 0.02 1.36 -0.02 -0.01 1 2 3 4 5 1.34 1.34 CEACAM20 -0.43 -0.55 0.79 -0.66 -1.00 1 2 3 4 5 1.34 1.34 ESSPL 0.87 3.52 4.87 -0.46 2.65 1 2 3 4 5 1.34 1.34 HS.563592 -0.41 -0.32 1.02 -0.33 -0.12 1 2 3 4 5 1.34 1.34 MT3 0.29 0.00 1.34 0.07 0.46 1 2 3 4 5 1.34 1.34 CCDC113 -0.27 -0.25 1.09 0.08 0.04 1 2 3 4 5 1.34 1.34 PROZ -1.75 -0.30 1.04 2.58 -0.88 1 2 3 4 5 1.34 1.34 HS.564059 1.54 -0.64 0.70 -1.19 0.20 1 2 3 4 5 1.34 1.34 OR52N1 -0.52 -0.27 1.07 2.10 -0.48 1 2 3 4 5 1.34 1.34 HS.525794 -0.56 -0.60 0.74 -0.25 -0.14 1 2 3 4 5 1.34 1.34 FGG 1.01 -0.13 1.21 3.09 -0.50 1 2 3 4 5 1.34 1.34 HS.543597 0.43 -0.04 1.30 -0.23 -0.34 1 2 3 4 5 1.34 1.34 MDFI -0.21 -0.92 0.41 0.02 -0.44 1 2 3 4 5 1.34 1.34 LOC649327 1.00 -0.12 1.21 1.33 -0.88 1 2 3 4 5 1.34 1.34 ADAMTS13 1.27 -0.24 1.10 -0.17 -0.27 1 2 3 4 5 1.34 1.34 HS.540146 0.33 0.19 1.53 0.30 -0.60 1 2 3 4 5 1.34 1.34 SYPL2 0.02 -2.23 -0.89 1.09 -1.99 1 2 3 4 5 1.34 1.34 HS.543987 0.49 -0.10 1.24 -0.12 -0.06 1 2 3 4 5 1.33 1.33 SGTB 1.79 0.34 1.68 0.60 1.22 1 2 3 4 5 1.33 1.33 HS.569365 1.54 -0.69 0.64 0.14 0.25 1 2 3 4 5 1.33 1.33 LOC649160 -0.02 0.20 1.54 0.08 -0.07 1 2 3 4 5 1.33 1.33 HS.310461 -0.25 -0.15 1.19 -0.09 -0.67 1 2 3 4 5 1.33 1.33 HS.538285 -0.15 -0.66 0.68 -0.51 -0.43 1 2 3 4 5 1.33 1.33 LOC128102 -1.17 -0.09 1.24 -0.26 2.67 1 2 3 4 5 1.33 1.33 ATP6V1C2 -1.74 -1.53 -0.20 -1.05 0.60 1 2 3 4 5 1.33 1.33 HS.531140 0.53 -0.33 1.00 2.05 -0.06 1 2 3 4 5 1.33 1.33 PRAMEF4 0.16 -0.86 0.47 -0.46 -0.25 1 2 3 4 5 1.33 1.33 HS.566813 1.13 -0.49 0.84 -0.39 0.13 1 2 3 4 5 1.33 1.33 CKMT1A -0.67 1.05 2.38 -0.40 -0.18 1 2 3 4 5 1.33 1.33 HS.565857 -0.06 -0.15 1.18 0.14 -0.32 1 2 3 4 5 1.33 1.33 CDSN -0.42 0.09 1.42 2.15 -0.44 1 2 3 4 5 1.33 1.33 HS.133050 0.23 0.15 1.48 -0.43 -0.25 1 2 3 4 5 1.33 1.33 HS.112720 2.66 0.21 1.54 1.69 -1.37 1 2 3 4 5 1.33 1.33 HS.537348 -0.22 0.48 1.81 0.42 -0.79 1 2 3 4 5 1.33 1.33 MPP4 2.87 -0.61 0.72 0.42 -1.02 1 2 3 4 5 1.33 1.33 NRG4 1.55 -0.28 1.05 1.58 0.25 1 2 3 4 5 1.33 1.33 FU40292 -1.56 0.04 1.37 -0.31 -1.33 1 2 3 4 5 1.33 1.33 C90RF139 -0.73 -1.64 -0.31 0.87 0.80 1 2 3 4 5 1.33 1.33 RASGEF1A -0.92 -1.46 -0.13 -1.44 -1.43 1 2 3 4 5 1.33 1.33 HS.571317 0.44 -0.71 0.62 0.76 0.75 1 2 3 4 5 1.33 1.33 HS.577504 -0.37 -0.74 0.59 -0.49 -0.93 1 2 3 4 5 1.33 1.33 HS.438374 -0.77 -0.48 0.84 -0.15 -0.21 1 2 3 4 5 1.33 1.33 C90RF14 0.59 -0.79 0.54 -0.05 1.64 1 2 3 4 1.33 1.33 HS.569064 -0.75 -0.89 0.44 -0.58 1.14 1 2 3 4 5 1.33 1.33 HIST3H2BB -0.38 -0.41 0.92 3.12 0.67 1 2 3 4 5 1.33 1.33 Table 3 88 HS.334096 0.51 -0.22 1.10 1.44 -0.14 1 2 3 4 5 1.33 1.33 C10ORF109 -0.05 -0.37 0.95 0.07 0.66 1 2 3 4 5 1.33 1.33 HS.212477 2.33 -1.00 0.33 0.67 1.39 1 2 3 4 5 1.33 1.33 NEUROD1 1.48 -0.51 0.81 2.02 1.01 1 2 3 4 5 1.33 1.33 HS.576509 -0.47 -0.56 0.76 3.84 -0.43 1 2 3 4 5 1.33 1.33 HOXC8 0.11 -0.20 1.13 0.66 -0.51 1 2 3 4 5 1.32 1.32 HS.507367 -0.14 -0.63 0.69 1.32 -0.03 1 2 3 4 5 1.32 1.32 CLCN1 -0.36 0.32 1.64 2.33 0.30 1 2 3 4 5 1.32 1.32 HS.196595 0.46 -0.38 0.94 -0.06 1.83 1 2 3 4 5 1.32 1.32 OR4F4 -0.02 -0.19 1.13 0.10 0.49 1 2 3 4 5 1.32 1.32 TDGF3 -0.20 -0.67 0.65 -0.19 -0.04 1 2 3 4 5 1.32 1.32 HS.568970 0.76 -0.75 0.57 0.35 1.66 1 2 3 4 5 1.32 1.32 TMEM132E -0.51 -0.75 0.57 -0.85 -0.26 1 2 3 4 5 1.32 1.32 HS.576924 1.03 -1.36 -0.04 1.96 0.29 1 2 3 4 5 1.32 1.32 HS.445931 -0.36 -0.57 0.75 -0.82 -0.44 1 2 3 4 5 1.32 1.32 LOC642620 1.04 -0.45 0.87 -0.42 1.25 1 2 3 4 5 1.32 1.32 C170RF82 0.13 -0.60 0.72 0.83 -0.28 1 2 3 4 5 1.32 1.32 HS.578886 -0.38 -0.50 0.82 -0.46 -0.35 1 2 3 4 5 1.32 1.32 COX7B2 0.54 -1.54 -0.22 -0.64 -0.85 1 2 3 4 5 1.32 1.32 HS.575234 -0.14 0.02 1.34 0.56 0.19 1 2 3 4 5 1.32 1.32 HS.540094 -0.38 -0.17 1.15 0.43 0.44 1 2 3 4 5 1.32 1.32 HS.563087 -0.76 -0.54 0.77 5.99 0.81 1 2 3 4 5 1.32 1.32 C40RF28 0.26 -1.19 0.13 0.98 2.64 1 2 3 4 5 1.32 1.32 LOC442480 2.58 0.95 2.26 0.42 2.67 1 2 3 4 5 1.31 1.31 HS.566333 -0.56 -0.45 0.87 -1.60 -1.23 1 2 3 4 5 1.31 1.31 LOC652842 -0.22 -0.11 1.20 1.38 -0.11 1 2 3 4 5 1.31 1.31 SPTB -0.46 -0.56 0.75 0.06 -0.25 1 2 3 4 5 1.31 1.31 HS.583921 0.02 0.01 1.32 0.50 -0.05 1 2 3 4 5 1.31 1.31 HS3ST5 -1.04 -0.55 0.76 -0.88 -0.46 1 2 3 4 5 1.31 1.31 LOC643965 -0.40 -0.70 0.61 0.18 -0.47 1 2 3 4 5 1.31 1.31 HS.539482 -0.07 -0.81 0.50 0.06 -0.72 1 2 3 4 5 1.31 1.31 HS.542874 2.69 -0.32 0.99 1.23 -0.21 1 2 3 4 5 1.31 1.31 C60RF174 0.16 -0.20 1.11 -0.94 3.06 1 2 3 4 5 1.31 1.31 LOC388906 -0.14 0.11 1.42 0.67 0.13 1 2 3 4 5 1.31 1.31 EFNA5 -0.24 -0.38 0.93 1.74 1.43 1 2 3 4 5 1.31 1.31 HMCN1 2.52 0.45 1.76 0.59 -0.54 1 2 3 4 5 1.31 1.31 HS.130457 -0.12 -0.34 0.97 -0.83 -0.39 1 2 3 4 5 1.31 1.31 LOC643910 0.72 -0.53 0.78 0.39 3.24 1 2 3 4 5 1.31 1.31 HS.579000 -0.49 -0.38 0.94 -0.48 0.52 1 2 3 4 5 1.31 1.31 HS.399958 -0.46 -0.51 0.80 -0.39 -0.33 1 2 3 4 5 1.31 1.31 HS.543898 -1.18 1.79 3.10 1.07 -0.25 1 2 3 4 5 1.31 1.31 HS.508287 0.18 0.89 2.20 -0.51 -0.22 1 2 3 4 5 1.31 1.31 HS.258077 -0.29 -0.28 1.02 0.11 -0.15 1 2 3 4 5 1.31 1.31 FU44216 -0.70 -1.06 0.24 0.13 -0.15 1 2 3 4 5 1.31 1.31 HS.432085 -0.20 -0.72 0.58 0.55 0.30 1 2 3 4 5 1.31 1.31 MAEL 0.17 -0.14 1.17 -0.19 -0.30 1 2 3 4 5 1.31 1.31 HS.291354 1.45 -0.61 0.70 1.05 0.29 1 2 3 4 5 1.31 1.31 HS.581603 -0.28 0.15 1.46 2.23 2.32 1 2 3 4 5 1.31 1.31 EP400NL -0.03 0.30 1.61 0.11 -0.20 1 2 3 4 5 1.31 1.31 Table 3 GPR32 -1.08 -0.16 1.14 0.02 0.22 1 2 3 4 5 1.30 1.30 HS.568969 1.55 -0.13 1.18 -0.08 3.58 1 2 3 4 5 1.30 1.30 GABRB2 -0.07 -0.91 0.39 -0.40 -0.86 1 2 3 4 5 1.30 1.30 HS.565548 0.01 0.45 1.75 0.32 -0.69 1 2 3 4 5 1.30 1.30 HS.542727 -0.26 -0.16 1.14 -0.24 -0.05 1 2 3 4 5 1.30 1.30 HS.581868 1.60 -0.65 0.65 0.99 0.37 1 2 3 4 5 1.30 1.30 HS.540956 1.37 -0.42 0.88 0.57 0.53 1 2 3 4 5 1.30 1.30 HS.428081 -0.75 -0.67 0.63 -1.09 -0.19 1 2 3 4 5 1.30 1.30 IGSF9 2.89 -0.71 0.59 0.66 -1.00 1 2 3 4 5 1.30 1.30 LOC642597 -0.38 -0.42 0.88 0.02 2.87 1 2 3 4 5 1.30 1.30 HS.537525 0.05 -0.25 1.05 -0.24 -0.37 1 2 3 4 5 1.30 1.30 MGC39581 1.22 -1.18 0.12 -0.61 -0.55 1 2 3 4 5 1.30 1.30 LOC651495 0.14 0.15 1.44 -0.05 0.92 1 2 3 4 5 1.30 1.30 HS.542360 -0.41 -0.83 0.47 -1.02 3.95 1 2 3 4 5 1.30 1.30 LOC651965 0.54 -0.33 0.97 -0.16 1.08 1 2 3 4 5 1.30 1.30 HS.546012 -0.54 -0.29 1.00 -0.43 -0.51 1 2 3 4 5 1.30 1.30 LOC343384 0.17 0.20 1.50 -0.08 -0.27 1 2 3 4 5 1.30 1.30 HS.573359 0.02 -0.07 1.22 -0.23 0.16 1 2 3 4 5 1.29 1.29 HS.544878 -0.17 -0.36 0.94 -0.05 0.82 1 2 3 4 5 1.29 1.29 OLFML3 -0.43 -0.40 0.89 -0.51 2.15 1 2 3 4 5 1.29 1.29 HS.133031 -0.90 -0.72 0.57 -0.49 -0.55 1 2 3 4 5 1.29 1.29 C40RF35 0.56 -0.43 0.86 3.60 0.74 1 2 3 4 5 1.29 1.29 KCNS1 0.90 -0.91 0.39 -0.64 -0.42 1 2 3 4 5 1.29 1.29 CACNA1S -0.17 0.24 1.53 -0.21 0.75 1 2 3 4 5 1.29 1.29 HS.563538 -0.42 -0.30 0.99 1.37 0.00 1 2 3 4 5 1.29 1.29 HS.582999 -0.85 0.07 1.35 0.32 1.35 1 2 3 4 5 1.29 1.29 LOC649041 0.15· -0.72 0.57 -0.74 -0.28 1 2 3 4 5 1.29 1.29 TBC1D8B -1.06 -0.89 0.40 6.98 -0.86 1 2 3 4 5 1.29 1.29 KRT84 2.05 -0.28 1.01 -0.29 0.29 1 2 3 4 5 1.29 1.29 HS.555514 0.66 -0.42 0.87 -0.04 0.13 1 2 3 4 5 1.29 1.29 MGC34821 -0.58 0.59 1.87 -0.73 0.66 1 3 4 5 1.29 1.29 C80RF54 -0.28 -0.42 0.87 0.03 -0.28 1 2 3 4 5 1.29 1.29 HS.514958 0.08 -0.11 1.18 0.03 -0.13 1 2 3 4 5 1.29 1.29 HS.48945 -0.07 -0.28 1.00 0.05 -0.04 1 2 3 4 5 1.29 1.29 HS.542459 -0.87 -0.72 0.57 0.26 0.59 1 2 3 4 5 1.29 1.29 HS.569905 2.61 0.41 1.70 4.55 2.23 1 2 3 4 5 1.28 1.28 CCDC73 -0.68 1.50 2.79 0.48 0.61 1 2 3 4 5 1.28 1.28 HS.583393 -0.35 -0.01 1.28 -0.47 2.84 1 2 3 4 5 1.28 1.28 BPIL3 3.56 -0.23 1.05 2.96 -0.01 1 2 3 4 5 1.28 1.28 LOC649771 0.07 -0.54 0.75 1.75 1.48 1 2 3 4 5 1.28 1.28 HS.574482 -0.71 1.47 2.76 0.22 -0.36 1 2 3 4 5 1.28 1.28 GRIA1 -0.43 -0.52 0.76 0.31 0.14 1 2 3 4 5 1.28 1.28 LOC730243 -0.18 0.08 1.36 -0.29 1.09 1 2 3 4 5 1.28 1.28 WNT9A 0.28 -0.22 1.06 1.33 0.08 1 2 3 4 5 1.28 1.28 HS.561153 -0.61 -0.77 0.51 -0.42 1.26 1 2 3 4 5 1.28 1.28 VGLL3 -0.88 -0.13 1.15 -0.80 -0.87 1 2 3 4 5 : 1.28 1.28 KRT81 -0.17 -0.32 0.96 0.33 0.06 1 2 3 4 5 1.28 1.28 LHFPL1 -0.36 -0.31 0.97 -0.28 -0.56 1 2 3 4 5 1.28 1.28 EPHA7 -0.02 -0.96 0.32 -1.28 -0.16 1 2 3 4 5 1.28 1.28 Table 3 90 HS.427844 -0.14 0.08 1.36 0.47 0.83 1 2 3 4 5 1.28 1.28 HS.560918 -0.75 -0.38 0.90 -0.62 0.36 1 2 3 4 5 1.28 1.28 HS.542849 -0.44 -0.96 0.32 2.40 1.07 1 2 3 4 5 1.28 1.28 HS.276586 0.21 -0.79 0.49 -0.34 0.10 1 2 3 4 5 1.28 1.28 HS.555624 -0.02 0.03 1.31 -0.17 -0.12 1 2 3 4 1.28 1.28 HS.559708 0.00 0.05 1.33 2.09 2.76 1 2 3 4 5 1.28 1.28 HS.579273 1.56 -0.64 0.64 0.26 -0.08 1 2 3 4 5 1.28 1.28 HS.551007 -0.16 -0.21 1.06 1.25 1.18 1 2 3 4 5 1.28 1.28 LOC647331 -0.07 -0.07 1.21 0.23 0.59 1 2 3 4 5 1.28 1.28 HS.538454 -0.81 -0.30 0.98 1.04 0.54 1 2 3 4 5 1.28 1.28 ADCYAP1R1 0.07 -0.98 0.29 -0.16 -0.48 1 2 3 4 5 1.28 1.28 HS. 121473 2.02 -0.44 0.83 -0.17 -0.13 1 2 3 4 5 1.27 1.27 VGF 1.80 -0.08 1.19 3.41 0.13 1 2 3 4 5 1.27 1.27 OR5K2 -0.24 -0.39 0.89 -0.24 0.06 1 2 3 4 5 1.27 1.27 S100A7A -1.18 -0.35 0.92 -0.61 -0.20 1 2 3 4 5 1.27 1.27 HS.26010 -0.53 -0.31 0.96 -0.12 -0.14 1 2 3 4 5 1.27 1.27 LOC730833 0.11 -0.46 0.82 -0.10 0.32 1 2 3 4 5 1.27 1.27 LOC646246 0.46 -0.59 0.68 0.56 -0.76 1 2 3 4 5 1.27 1.27 ADAM20 -0.70 -1.01 0.26 -0.35 -0.94 1 2 3 4 5 1.27 1.27 HS.160567 0.72 1.23 2.51 -0.35 -0.61 1 2 3 4 5 1.27 1.27 CYP26C1 -0.58 -0.82 0.45 0.43 -0.40 1 2 3 4 5 1.27 1.27 LOC646461 1.39 1.99 3.26 0.93 1.05 1 2 3 4 5 ; 1.27 1.27 HS.574471 -0.78 -0.42 0.85 -0.38 -0.54 1 2 3 4 5 1.27 1.27 LOC440848 -0.06 -0.52 0.75 0.76 0.28 1 2 3 4 5 1.27 1.27 HS.579290 -0.38 -0.14 1.13 0.17 0.96 1 2 3 4 5 1.27 1.27 HS.541491 -1.18 -0.47 0.80 -0.58 1.01 1 2 3 4 5 1.27 1.27 LOC440287 -0.51 -0.36 0.91 0.50 -0.16 1 2 3 4 5 1.27 1.27 HS.435121 0.64 -0.21 1.06 -0.71 -0.21 1 2 3 4 5 1.27 1.27 GSTTP1 1.72 -1.44 -0.17 0.58 2.30 1 2 3 4 5 1.27 1.27 LOC651638 -0.69 0.61 1.87 -0.57 -1.36 1 2 3 4 5 ! 1.27 1.27 OR52I2 1.09 -0.47 0.79 3.00 0.24 1 2 3 4 5 1.27 1.27 KLK10 0.67 -0.52 0.75 -0.45 0.81 1 2 3 4 1.27 1.27 HS.149786 -0.68 -0.73 0.54 -0.56 -0.19 1 2 3 4 5 1.27 1.27 DKFZP547H025 0.97 -0.17 1.10 0.13 0.09 1 2 3 4 5 1.27 1.27 HS.570209 -0.14 -0.24 1.03 -0.19 -0.29 1 2 3 4 5 1.26 1.26 C10ORF129 0.22 -0.28 0.98 -0.65 0.17 1 2 3 4 5 1.26 1.26 HS.572355 2.82 0.07 1.33 -0.57 -0.29 1 2 3 4 5 1.26 1.26 WDR42C 2.11 -0.63 0.63 0.23 -0.38 1 2 3 4 5 1.26 1.26 HS.582165 -0.13 -0.21 1.05 -0.15 -0.14 1 2 3 4 5 1.26 1.26 LOC728248 -1.00 0.50 1.76 -0.41 -1.07 1 2 3 4 5 1.26 1.26 PLXNA4B -0.59 -1.67 -0.41 3.24 2.46 1 2 3 4 5 1.26 1.26 HS.565555 -0.72 0.31 1.58 -0.67 2.13 1 2 3 4 5 1.26 1.26 HS.213472 -0.43 -0.50 0.76 0.40 -0.49 1 2 3 4 5 1.26 1.26 HS.130361 -0.46 -0.16 1.10 0.19 -0.10 1 2 3 4 5 1.26 1.26 CADM2 -0.74 0.66 1.92 0.01 -0.60 1 2 3 4 5 1.26 1.26 HS.564718 -0.23 -0.51 0.75 1.44 -1.32 1 2 3 4 5 1.26 1.26 LOC642515 1.31 -0.94 0.32 0.05 -0.32 1 2 3 4 5 1.26 1.26 PCDH9 -0.51 -0.48 0.78 -0.07 1.11 1 2 3 4 5 1.26 1.26 HS.525484 -0.09 -0.34 0.92 0.04 0.19 1 2 3 4 5 1.26 1.26 Table 3 9 1

HS.540210 1.13 -0.33 0.93 0.76 0.45 1 2 3 4 5 1.26 1.26 LOC729973 -0.19 -1.18 0.07 -0.55 -0.51 1 2 3 4 5 1.26 1.26 LOC440871 1.44 -0.53 0.73 1.24 -0.02 1 2 3 4 5 1.25 1.25 REN -0.17 0.20 1.46 -0.03 -0.12 1 2 3 4 5 1.25 1.25 ANKRD1 1.40 -0.03 1.22 0.60 0.95 1 2 3 4 5 1.25 1.25 C10RF65 0.45 -0.05 1.21 0.66 -0.05 1 2 3 4 5 1.25 1.25 HS.538378 -0.20 -0.25 1.01 -0.13 0.44 1 2 3 4 5 1.25 1.25 LOC651122 -0.16 0.01 1.26 -0.13 -0.12 1 2 3 4 5 1.25 1.25 HS.278163 -0.02 -0.88 0.38 0.75 1.09 1 2 3 4 5 1.25 1.25 C18ORF20 -0.21 -0.15 1.10 0.66 -0.33 1 2 3 4 5 1.25 1.25 HS.538863 1.79 2.04 3.29 -0.62 -1.28 1 2 3 4 5 1.25 1.25 HS.578613 4.54 1.05 2.30 -0.22 -0.94 1 2 3 4 5 1.25 1.25 HS.565378 0.34 -0.21 1.04 0.72 -0.34 1 2 3 4 5 1.25 1.25 HS.540914 -0.32 -0.55 0.70 -0.73 0.06 1 2 3 4 5 1.25 1.25 GALNT5 -0.26 1.13 2.38 1.35 2.70 1 2 3 4 5 1.25 1.25 HS.545253 -0.59 -0.31 0.94 -1.01 -0.07 1 2 3 4 5 1.25 1.25 PGK2 -0.59 -0.12 1.13 2.25 1.59 1 2 3 4 5 1.25 1.25 HS.21237 2.96 -1.23 0.02 -1.46 -0.51 1 2 3 4 5 1.25 1.25 B P ER -0.91 -1.06 0.19 0.50 -0.70 1 2 3 4 5 1.25 1.25 RNASE9 5.20 1.89 3.14 0.43 2.30 1 2 3 4 5 1.25 1.25 HS.566026 1.13 0.27 1.51 -0.12 1.75 1 2 3 4 5 1.25 1.25 HS.545825 2.64 -0.90 0.35 -0.91 0.06 1 2 3 4 5 1.25 1.25 HS.580550 -0.62; -0.24 1.01 1.47 -0.31 1 2 3 4 5 1.25 1.25 HS.407621 -0.49 -0.28 0.97 -0.10 1.01 1 2 3 4 5 1.25 1.25 HS.537595 -0.07 0.10 1.35 -0.49 -0.10 1 2 3 4 5 1.25 1.25 APEG1 -0.18 -0.41 0.84 0.13 0.94 1 2 3 4 5 1.25 1.25 LOC254398 0.66 -0.02 1.23 0.02 1.58 1 2 3 4 5 1.25 1.25 MT4 -1.00 -0.54 0.71 1.36 1.45 1 2 3 4 5 1.25 1.25 HS.561622 0.21 -0.72 0.53 -0.40 0.07 1 2 3 4 5 1.25 1.25 LOC653280 -0.27 0.13 1.37 -0.42 -0.36 1 2 3 4 5 1.24 1.24 HS.129561 -0.36 -0.23 1.01 0.31 -0.52 1 2 3 4 5 1.24 1.24 MFRP 3.43 0.12 1.37 -0.33 2.51 1 2 3 4 5 1.24 1.24 HS.565189 -0.33 -0.14 1.11 0.76 -0.36 1 2 3 4 5 1.24 1.24 LRRC24 0.20 -1.14 0.11 -0.71 0.08 1 2 3 4 5 1.24 1.24 HS.545502 3.13 -0.15 1.09 0.04 -0.33 1 2 3 4 5 1.24 1.24 SLC35F3 -0.35 -0.29 0.95 0.08 -0.32 1 2 3 4 5 1.24 1.24 LOC648424 2.79 2.36 3.60 -0.70 1.66 1 2 3 4 5 1.24 1.24 SPRR4 -0.42 -0.25 0.99 0.62 -0.34 1 2 3 4 5 1.24 1.24 HS.563654 3.15 -0.20 1.04 0.04 1.02 1 2 3 4 5 1.24 1.24 LOC651463 -0.85 -0.48 0.77 0.41 -0.66 1 2 3 4 5 1.24 1.24 IQCH 0.90 -0.92 0.32 -0.31 -0.56 1 2 3 4 5 1.24 1.24

ELAVL2 -0.22 -0.56 0.68 -0.55 -0.50 1 2 3 4 5 : 1.24 1.24

OR10V1 -1.42 -0.85 0.39 -0.68 -1.61 1 2 3 4 5 ; 1.24 1.24 HS.561412 -0.37 -0.77 0.47 2.05 -0.79 1 2 3 4 5 1.24 1.24 WFDC12 -0.59 -1.14 0.10 -1.13 -0.75 1 2 3 4 5 1.24 1.24 C20ORF77 -0.55 -0.71 0.53 -0.55 0.17 1 2 3 4 5 1.24 1.24 HS.580470 0.46 -0.63 0.60 0.13 -0.54 1 2 3 4 5 1.24 1.24 BMX 0.29 0.67 1.90 -0.06 0.61 1 2 3 4 5 1.24 1.24 LOC648174 0.32 0.54 1.77 0.06 0.15 1 2 3 4 5 1.24 1.24 Table 3 92 LOC652490 0.85 -0.37 0.87 0.07 1.73 1 2 3 4 5 1.24 1.24 NDUFS6 -0.50 -0.43 0.81 -0.44 0.16 1 2 3 4 5 1.24 1.24 HS.582436 2.19 0.08 1.32 -0.20 3.01 1 2 3 4 5 1.24 1.24 HS.582534 -0.20 -0.33 0.91 -0.10 -0.06 1 2 3 4 5 1.24 1.24 CLPS 3.28 -1.18 0.05 -0.90 0.76 1 2 3 4 5 1.24 1.24 TLL1 1.41 -1.80 -0.57 2.01 1.41 1 2 3 4 5 1.24 1.24 HS.528290 -0.42 -0.33 0.91 -0.16 0.22 1 2 3 4 5 1.24 1.24 LOC643324 -0.27 -0.18 1.06 0.20 0.17 1 2 3 4 5 1.23 1.23 TULP1 -0.44 -0.61 0.62 -0.67 -0.54 1 2 3 4 5 1.23 1.23 GPR150 -0.34 0.30 1.53 0.33 0.41 1 2 3 4 5 1.23 1.23 ARHGAP6 1.67 0.04 1.27 0.28 -0.39 1 2 3 4 5 1.23 1.23 NKAIN4 1.49 -0.71 0.52 -0.51 0.20 1 2 3 4 1.23 1.23 HS.507932 0.29 0.19 1.43 -0.44 0.89 1 2 3 4 5 1.23 1.23 LOC652848 -0.11 -0.03 1.20 1.49 1.92 1 2 3 4 5 1.23 1.23 LOC389217 1.04 -1.34 -0.11 -0.78 -0.20 1 2 3 4 5 1.23 1.23 C30RF46 0.33 0.09 1.32 -0.01 0.17 1 2 3 4 5 1.23 1.23 HS.560862 -0.41 0.21 1.44 -0.27 0.90 1 2 3 4 5 1.23 1.23 LOC646554 -0.35 -0.09 1.14 -0.17 1.14 1 2 3 4 5 1.23 1.23 MEST -0.16 -0.39 0.84 1.63 0.06 1 2 3 4 5 1.23 1.23 HS.581655 -0.43 -0.07 1.16 0.18 0.56 1 2 3 4 5 1.23 1.23 INSL6 -0.30 -0.91 0.32 1.37 3.28 1 2 3 4 5 1.23 1.23 HS.537339 0.27 -0.01 1.22 0.29 2.32 1 2 3 4 5 1.23 1.23 CX3CL1 -0.01 -0.48 0.75 -0.95 -0.27 1 2 3 4 5 1.23 1.23 FAM75A7 -1.04 0.30 1.52 0.92 0.30 1 2 3 4 5 1.23 1.23 HS.436868 0.78 -1.52 -0.29 0.49 0.44 1 2 3 4 5 1.23 1.23 HS.561762 -0.89 -0.72 0.51 -1.14 -1.02 1 2 3 4 5 1.23 1.23 LOC644669 -0.60 1.76 2.99 0.38 -0.44 1 2 3 4 5 1.23 1.23 HS.576980 0.36 -0.05 1.17 0.46 1.45 1 2 3 4 5 1.23 1.23 LOC649578 0.08 0.69 1.91 -0.39 -0.37 1 2 3 4 5 1.22 1.22 HS.572512 1.73 0.31 1.53 0.07 -0.11 1 2 3 4 5 1.22 1.22 HS.363154 1.90 -1.07 0.16 0.09 -0.98 1 2 3 4 5 1.22 1.22 HS.580556 -0.54 -0.78 0.44 1.22 2.32 1 2 3 4 5 1.22 1.22 A2ML1 1.05 -0.15 1.07 0.74 2.41 1 · 2 3 4 5 1.22 1.22 HS.543823 -0.32 -0.32 0.90 0.44 0.12 1 2 3 4 5 1.22 1.22 HS.156409 0.22 0.08 1.30 0.56 -0.45 1 2 3 4 5 1.22 1.22 HS.577829 -0.77 -0.54 0.68 -0.41 -0.20 1 2 3 4 5 1.22 1.22 HS.566282 -0.14 -0.32 0.91 1.70 0.96 1 2 3 4 5 1.22 1.22 HS.581575 0.70 -0.32 0.90 -0.95 2.24 1 2 3 4 5 1.22 1.22 PAX3 1.60, -1.08 0.14 -1.30 -1.10 1 2 3 4 5 1.22 1.22 HS.541817 1.13 0.83 2.05 0.54 -0.12 1 2 3 4 5 1.22 1.22 HS.122125 -0.40 -0.65 0.57 -0.13 -0.05 1 2 3 4 5 1.22 1.22 HS.563328 -0.49 0.01 1.23 0.15 0.97 ' 1 2 3 4 5 1.22 1.22 HS.565868 -0.19 -0.36 0.86 -0.01 -0.01 1 2 3 4 5 1.22 1.22 LOC154907 5.16 -0.65 0.57 0.69 0.49 1 2 3 4 5 1.22 1.22 HS.239108 0.12 -0.94 0.28 -0.31 -0.13 1 2 3 4 5 1.22 1.22 LOC644887 -0.58 -0.06 1.16 -0.71 -0.36 1 2 3 4 5 1.22 1.22 LOC651333 -0.76 -0.37 0.85 -0.60 0.08 1 2 3 4 5 1.22 1.22 HS.542129 -0.43 -0.42 0.80 -0.15 0.76 1 2 3 4 5 1.22 1.22 HS.527731 0.43 1.19 2.40 0.52 -0.34 1 2 3 4 5 1.22 1.22 Table 3 93 HS.542314 0.51 -0.28 0.94 0.92 -0.06 1 2 3 4 5 1.22 1.22 HS.545642 -0.45 -0.38 0.84 -0.13 -0.49 1 2 3 4 5 1.22 1.22 HS.568626 -0.83 -1.03 0.18 -0.55 1.54 1 2 3 4 5 1.22 1.22 HS.537103 2.49 -0.84 0.38 3.52 1.77 1 2 3 4 5 1.22 1.22 DSCAML1 0.94 -0.74 0.47 4.94 3.69 1 2 3 4 5 1.22 1.22 LOC649770 0.37 -0.01 1.21 -0.20 2.83 1 2 3 4 5 1.22 1.22 HS.128668 -0.49 -0.42 0.80 -0.11 -0.07 1 2 3 4 5 1.22 1.22 THAP8 -0.38 -0.75 0.46 -0.33 -0.65 1 2 3 4 5 1.22 1.22 PCDHIO -0.67 -0.77 0.45 -0.45 0.60 1 2 3 4 5 1.22 1.22 C1QTNF3 -0.08 -0.34 0.87 0.42 0.35 1 2 3 4 5 1.22 1.22 SUGT1P 1.95 -0.28 0.94 -0.31 0.49 1 2 3 4 5 1.22 1.22 HS.432394 1.32 -0.08 1.14 -0.25 -0.15 1 2 3 4 5 1.22 1.22 LOC653427 0.45 -0.09 1.12 -0.20 -0.01 1 2 3 4 5 1.21 1.21 HRNBP3 -0.22 -0.34 0.88 -0.51 -0.38 1 2 3 4 5 1.21 1.21 HS.149643 -0.08 1.29 2.50 1.18 -0.22 1 2 3 4 5 1.21 1.21 HS.583801 -0.52 -0.81 0.40 0.37 -0.28 1 2 3 4 5 1.21 1.21 HS.567071 0.01 0.19 1.40 -0.30 0.23 1 2 3 4 5 1.21 1.21 LOC652529 0.43 0.12 1.33 -0.08 0.11 1 2 3 4 5 1.21 1.21 LOC642245 -1.02 -1.35 -0.14 -0.72 0.59 1 2 3 4 5 1.21 1.21 HS.565608 -0.33 3.18 4.39 0.19 0.32 1 2 3 4 5 1.21 1.21 SLC9A3R2 0.80 -0.24 0.97 0.32 -0.40 1 2 3 4 5 1.21 1.21 KLC3 -0.07 -0.18 1.03 -0.62 -0.28 1 2 3 4 5 1.21 1.21 KRT13 2.io; 0.55 1.76 0.87 0.57 1 2 3 4 5 1.21 1.21 HS.543172 0.06 -0.21 1.00 0.00 0.30 1 2 3 4 5 1.21 1.21 HS.131181 -0.36: -1.36 -0.15 -0.95 -0.57 1 2 3 4 5 1.21 1.21 HS.545843 0.12 -0.76 0.45 -0.22 -0.31 1 2 3 4 5 1.21 1.21 OR5AP2 -1.02 -0.79 0.42 3.18 0.13 1 2 3 4 5 1.21 1.21 CTF1 -0.14 -0.18 1.03 0.17 . -0.03 1 2 3 4 5 1.21 1.21 KIAA1755 -0.62 -0.71 0.50 0.20 -0.23 1 2 3 4 5 1.21 1.21 HS.575928 0.22 -0.44 0.77 0.15 -0.68 1 2 3 4 5 1.21 1.21 HS.569110 -0.61 -0.35 0.85 0.30 0.32 1 2 3 4 5 1.20 1.20 HS.563695 0.21 -0.30 0.90 1.94 1.42 1 2 3 4 5 1.20 1.20 PRSS2 -0.24 -0.55 0.65 0.29 -0.58 1 2 3 4 5 1.20 1.20 HS.133851 -1.04 2.40 3.60 2.44 1.04 1 2 3 4 5 1.20 1.20 HS.544685 1.06 0.13 1.33 1.15 1.17 1 2 3 4 5 1.20 1.20 HS.576834 0.07 -0.35 0.85 0.53 -0.15 1 2 3 4 5 1.20 1.20 HS.497583 4.11 -1.74 -0.54 2.83 -0.93 1 2 3 4 5 1.20 1.20 HS.565437 0.09 -0.21 0.99 2.09 -0.29 1 2 3 4 5 1.20 1.20 TRIM16 -0.54 -0.83 0.37 0.44 0.28 1 2 3 4 5 1.20 1.20 HS.580614 4.46 -0.74 0.46 0.82 1.84 1 2 3 4 5 1.20 1.20 HS.565509 -0.94 1.13 2.33 0.61 1.27 1 2 3 4 5 1.20 1.20 PCDHB17 0.20' -0.42 0.78 0.34 0.35 1 2 3 4 5 1.20 1.20 PDLIM4 0.55 3.78 4.98 -0.07 -1.06 1 2 3 4 5 1.20 1.20 USP28 -0.10 -0.08 1.12 0.69 -0.15 1 2 3 4 5 1.20 1.20 KLK3 -0.50 -0.85 0.34 -0.71 -1.04 1 2 3 4 5 1.20 1.20 HS.530149 -0.59 -0.28 0.92 -0.13 0.09 1 2 3 4 5 1.20 1.20 TPD52L1 -0.40 -1.05 0.15 -0.05 0.82 1 2 3 4 5 1.20 1.20 LYNX1 -0.43 -0.96 0.24 -1.43 0.77 1 2 3 4 5 1.20 1.20 LOC644727 2.91 -0.39 0.81 -0.81 -1.11 1 2 3 4 5 1.20 1.20 Table 3 94 HS.540023 -0.33 0.60 1.80 1.08 -0.17 1 2 3 4 5 1.20 1.20 LOC647958 0.39 0.97 2.17 0.96 -0.30 1 2 3 4 5 1.20 1.20 HS.195549 1.57 -0.38 0.82 -0.49 -0.01 1 2 3 4 5 1.20 1.20 HS.514564 -0.65 -0.89 0.30 0.83 1.20 1 2 3 4 1.20 1.20 HS.536009 0.17 -0.37 0.83 -0.28 0.12 1 2 3 4 5 1.20 1.20 LOC645342 1.34 -0.37 0.83 -1.20 -0.48 1 2 3 4 5 1.20 1.20 HS.403452 4.08 0.05 1.24 0.34 0.56 1 2 3 4 5 1.20 1.20 HS.538881 0.64 -0.46 0.74 -0.41 0.20 1 2 3 4 5 1.20 1.20 HS.544440 -0.39 0.41 1.60 0.87 -0.39 1 2 3 4 5 1.20 1.20 HS.554101 0.28 -0.29 0.90 2.75 0.98 1 2 3 4 5 1.19 1.19 LOC645078 -1.27 -1.52 -0.33 2.59 0.61 1 2 3 4 5 1.19 1.19 TAF9B -0.57 -0.71 0.48 -0.24 1.39 1 2 3 4 5 1.19 1.19 HS.90221 0.20 -0.02 1.17 0.10 -0.11 1 2 3 4 5 1.19 1.19 FU46347 0.63 -0.11 1.08 1.36 -0.78 1 2 3 4 5 1.19 1.19 C20RF51 -0.33 -1.26 -0.07 -0.17 1.69 1 2 3 4 5 1.19 1.19 LOC643747 -0.65 -0.54 0.65 0.63 0.49 1 2 3 4 5 1.19 1.19 OR6B2 0.15 -0.60 0.59 -0.17 -0.46 1 2 3 4 5 1.19 1.19 HS.538107 -0.18 0.13 1.32 0.97 0.24 1 2 3 4 5 1.19 1.19 MGC10646 -0.06 0.10 1.29 -0.53 0.51 1 2 3 4 5 1.19 1.19 HS.511073 -0.88 -0.66 0.53 -0.36 -0.67 1 2 3 4 5 1.19 1.19 FU13236 0.59 -0.09 1.10 -0.35 -0.05 1 2 3 4 5 1.19 1.19 HS.436335 0.75 -0.05 1.13 0.32 -0.03 1 2 3 4 5 1.19 1.19 HS.574945 0.72 -0.22 0.97 -0.32 -0.49 1 2 3 4 5 1.19 1.19 LOC139587 -0.42 -0.29 0.90 -0.43 0.40 1 2 3 4 5 1.19 1.19 HS.127509 -0.11 -0.47 0.72 -0.02 -0.05 1 2 3 4 5 1.19 1.19 C130RF35 -0.06 -0.59 0.60 -0.80 -0.35 1 2 3 4 5 1.19 1.19 HS.270824 -0.37 -0.63 0.56 -0.37 -0.68 1 2 3 4 5 1.19 1.19 LOC650429 -0.32 -0.27 0.92 -0.19 2.12 1 2 3 4 5 1.19 1.19 TSPYL6 0.10 -0.74 0.45 -0.08 -0.70 1 2 3 4 5 1.19 1.19 CBLC 0.09 -0.73 0.45 -0.37 -0.37 1 2 3 4 5 1.19 1.19 HS.277346 0.09 0.14 1.32 0.85 0.00 1 2 3 4 5 1.18 1.18 PN A2 -0.18 -0.26 0.92 -0.17 -0.17 1 2 3 4 5 1.18 1.18 P0F1B -0.40 -0.52 0.67 2.77 0.96 1 2 3 4 5 1.18 1.18 C90RF31 -0.37 -0.35 0.83 1.16 0.54 1 2 3 4 5 1.18 1.18 HS.565314 -0.01 -0.69 0.49 -0.61 0.12 1 2 3 4 5 1.18 1.18 CDKN2A -0.23 -0.36 0.82 -0.46 -0.01 1 2 3 4 5 1.18 1.18 HS.571122 -0.30 0.57 1.75 0.17 1.68 1 2 3 4 5 1.18 1.18 LOC650543 -0.19 -0.59 0.59 1.47 -0.09 1 2 3 4 5 1.18 1.18 KIAA0953 -0.29 -0.35 0.83 -0.33 0.65 1 2 3 4 5 1.18 1.18 HS.544279 -1.00 -0.87 0.31 1.63 0.34 1 2 3 4 5 1.18 1.18 HS.534703 0.65 -0.19 0.99 0.26 2.67 1 2 3 4 5 1.18 1.18 HS.579564 1.32 -0.45 0.73 -0.52 1.45 1 2 3 4 5 1.18 1.18 HS.565379 0.17 0.50 1.68 1.30 -0.13 1 2 3 4 5 1.18 1.18 RPE -0.17 0.51 1.69 -0.14 0.04 1 2 3 4 5 1.18 1.18 HS.559830 -0.19 -0.58 0.60 -0.01 -0.27 1 2 3 4 5 1.18 1.18 HS.529589 -0.61 -0.31 0.87 -0.36 0.09 1 2 3 4 5 1.18 1.18 REG1A -0.37 -0.93 0.25 0.17 0.95 1 2 3 4 5 1.18 1.18 HS.537439 -0.38 -0.21 0.97 0.21 0.36 1 2 3 4 5 1.18 1.18 LIFR 1.36 -0.95 0.22 0.01 -0.60 1 2 3 4 5 1.18 1.18 Table 3 95 C90RF47 -0.35 -0.67 0.50 0.14 -0.43 1 2 3 4 5 1.17 1.17 HS.576036 -0.06 0.97 2.15 -0.09 -0.42 1 2 3 4 5 1.17 1.17 WNT4 1.62 -1.01 0.16 -0.73 -0.75 1 2 3 4 5 1.17 1.17 HS.544529 -0.15 -0.13 1.05 0.23 -0.18 1 2 3 4 5 1.17 1.17 EDIL3 0.63 -1.02 0.15 -0.53 1.08 1 2 3 4 5 1.17 1.17 HS.147726 1.83 -0.16 1.01 -0.43 1.44 1 2 3 4 5 1.17 1.17 HS.170193 0.32 0.00 1.17 -0.95 -0.58 1 2 3 4 5 1.17 1.17 HS.542840 -0.93 -0.99 0.18 -0.49 0.88 1 2 3 4 5 1.17 1.17 CRYBB1 0.71 -0.45 0.72 0.04 0.59 1 2 3 4 5 1.17 1.17 HS.508986 -0.65 0.36 1.52 -0.39 -0.61 1 2 3 4 5 1.17 1.17 HS.442058 -1.63 -0.55 0.62 2.27 -0.84 1 2 3 4 5 1.17 1.17 HS.542081 3.30 -1.19 -0.02 -1.19 0.08 1 2 3 4 5 1.17 1.17 OR7G2 -0.74 -0.93 0.24 -0.48 -0.09 1 2 3 4 5 1.17 1.17 C1QTNF5 -1.01 -0.16 1.01 2.64 1.21 1 2 3 4 5 1.17 1.17 LOC441996 -1.08 0.01 1.18 -0.62 0.45 1 2 3 4 5 1.17 1.17 HS.584041 -0.22 -0.57 0.59 -0.15 -0.16 1 2 3 4 5 1.17 1.17 OR10T2 -0.67 0.03 1.20 -0.03 1.24 1 2 3 4 5 1.17 1.17 HS.333862 2.30 -0.56 0.61 -0.22 -0.36 1 2 3 4 5 1.17 1.17 HS.547525 0.50 -0.78 0.38 -0.16 -0.36 1 2 3 4 5 1.17 1.17 HS.561660 -0.66 0.06 1.23 -0.35 0.06 1 2 3 4 5 1.17 1.17 LGR5 -0.33 -0.34 0.83 2.68 -0.72 1 2 3 4 5 1.16 1.16 LOC440917 -0.62 0.75 1.92 -0.11 -0.74 1 2 3 4 5 1.16 1.16 LOC728145 -0.30 -0.36 0.80 0.76 -0.03 1 2 3 4 5 1.16 1.16 HS.577827 -0.59 -0.74 0.42 -1.14 -0.46 1 2 3 4 5 1.16 1.16 HS.573306 0.45 -0.96 0.20 -0.85 -0.73 1 2 3 4 5 1.16 1.16 TMEM16A 1.05 1.36 2.52 0.09 -0.51 1 2 3 4 5 1.16 1.16 HS.333771 0.42 -0.04 1.12 -0.08 -0.01 1 2 3 4 5 1.16 1.16 SCG2 -0.94 -1.15 0.01 -0.39 0.24 1 2 3 4 5 1.16 1.16 HECW1 0.88 -0.89 0.28 -0.89 0.23 1 2 3 4 5 1.16 1.16 HS.102428 -0.12 -0.17 0.99 0.16 0.22 1 2 3 4 5 1.16 1.16 FAT2 0.26 -1.43 -0.27 2.22 -0.42 1 2 3 4 5 1.16 1.16 PMCH 0.09 -1.00 0.17 3.34 -1.06 1 2 3 4 5 1.16 1.16 HS.549667 0.07 -0.05 1.11 -0.11 -0.12 1 2 3 4 5 1.16 1.16 VSNL1 -1.97 -1.41 -0.25 -0.38 1.36 1 2 3 4 5 1.16 1.16 HS.524849 0.59 -0.77 0.39 3.00 0.41 1 2 3 4 5 1.16 1.16 HS.545328 -0.07 0.38 1.54 3.42 -1.11 1 2 3 4 5 1.16 1.16 RTL1 0.14 1.35 2.51 -0.10 -0.04 1 2 3 4 5 1.16 1.16 HS.550799 -0.11 -0.11 1.05 -0.13 -0.22 1 2 3 4 5 1.16 1.16 HS.543795 5.06 0.49 1.66 1.52 0.17 1 2 3 4 5 1.16 1.16 ELAVL4 0.19 -0.23 0.93 0.52 -0.72 1 2 3 4 5 1.16 1.16 HS.566288 0.20 -0.24 0.92 0.97 -0.36 1 2 3 4 5 1.16 1.16 LOC340204 -0.72 -0.06 1.10 -0.53 -0.55 1 2 3 4 5 1.16 1.16 CBLN1 0.09 -0.07 1.09 -0.96 2.13 1 2 3 4 5 1.16 1.16 HS.531320 -0.44 -0.45 0.71 0.49 0.83 1 2 3 4 5 1.16 1.16 HS.541043 -0.23 -0.22 0.94 0.22 0.42 1 2 3 4 5 1.16 1.16 OR4F3 0.67 -0.44 0.72 0.78 0.46 1 2 3 4 5 1.16 1.16 HS.486535 -0.38 -0.12 1.03 -0.31 -0.32 1 2 3 4 5 1.16 1.16 LOC728216 -0.09 -0.15 1.01 0.03 -0.04 1 2 3 4 5 1.16 1.16 LOC255649 1.64 -0.54 0.62 0.27 -0.30 1 2 3 4 5 1.16 1.16 Table 3 96 HS. 148447 0.23 0.13 1.29 -0.31 0.02 1 2 3 4 5 1.16 1.16 HNRNPCL1 -0.34 -0.29 0.86 2.05 -0.32 1 2 3 4 5 1.16 1.16 AADAT -1.10 -0.01 1.15 0.88 1.62 1 2 3 4 5 1.15 1.15 HS.554288 1.51 0.23 1.39 0.42 0.50 1 2 3 4 5 1.15 1.15 HS.545680 0.25 0.40 1.55 -0.09 -0.12 1 2 3 4 5 1.15 1.15 IBSP 0.32 -0.21 0.95 0.27 -0.06 1 2 3 4 5 1.15 1.15 HS.132541 -0.27 0.05 1.20 0.56 -0.61 1 2 3 4 5 1.15 1.15 AQP7 -0.11 -0.54 0.61 -0.68 -0.16 1 2 3 4 5 1.15 1.15 HS.560109 -0.48 -0.59 0.56 -0.39 -0.22 1 2 3 4 5 1.15 1.15 SPINK5 -0.07 -0.23 0.92 1.13 0.33 1 2 3 4 5 1.15 1.15 HS.498118 0.65 -0.05 1.10 -0.08 0.05 1 2 3 4 5 1.15 1.15 CNGB3 3.78 -1.25 -0.10 0.66 -0.66 1 2 3 4 5 1.15 1.15 KRTAP3-1 -0.43 -0.25 0.91 -0.04 -0.73 1 2 3 4 5 1.15 1.15 C140RF180 0.25 -0.16 0.99 0.55 0.26 1 2 3 4 5 1.15 1.15 GALNTL5 -0.38 0.20 1.35 -1.46 0.39 1 2 3 4 5 1.15 1.15 P0P2 0.20 0.22 1.37 -0.33 -0.23 1 2 3 4 5 1.15 1.15 PVRL1 0.12 -0.55 0.60 -0.45 0.39 1 2 3 4 5 1.15 1.15 LOC653582 0.31 -0.17 0.98 0.54 0.44 1 2 3 4 5 1.15 1.15 KCTD4 -0.73 -0.97 0.18 -1.08 0.39 1 2 3 4 5 1.15 1.15 LOC653620 -0.42 -0.76 0.39 -0.36 -0.05 1 2 3 4 5 1.15 1.15 STK32A -0.40 -0.36 0.79 -0.84 -1.38 1 2 3 4 5 1.15 1.15 GIPC3 0.23 -1.45 -0.31 -0.23 -1.27 1 2 3 4 5 1.15 1.15 HS.577474 -0.14 -0.95 0.20 -0.71 3.84 1 2 3 4 5 1.15 1.15 HS.526519 0.00 -0.56 0.59 -0.13 0.17 1 2 3 4 5 1.15 1.15 TMEM120B 1.46 -0.44 0.71 0.39 -0.34 1 2 3 4 5 1.15 1.15 HS.131022 1.10 -0.51 0.64 0.95 1.58 1 2 3 4 5 1.15 1.15 SLC01B3 1.59 -0.95 0.20 1.43 1.06 1 2 3 4 5 1.15 1.15 LOC388160 -0.33 -0.02 1.13 0.14 -0.11 1 2 3 4 5 1.15 1.15 PRSS33 1.33 -0.95 0.20 -0.71 3.92 1 2 3 4 5 1.15 1.15 HS.543727 1.09 0.28 1.43 3.38 -0.08 1 2 3 4 5 1.15 1.15 HS.575832 -0.53 -0.17 0.97 -0.51 -0.50 1 2 3 4 5 1.15 1.15 HS.569211 -0.28 -0.74 0.41 0.38 -0.61 1 2 3 4 5 1.15 1.15 HS.564104 -0.37 -1.13 0.02 -0.34 1.22 1 2 3 4 5 1.15 1.15 TIMM13 -0.28 -0.42 0.72 -0.14 -0.31 1 2 3 4 5 1.15 1.15 CHR415SYT 0.12 -0.83 0.32 -1.43 -0.87 1 2 3 4 5 1.15 1.15 OR14A16 0.73 -1.87 -0.72 -0.30 0.25 1 2 3 4 5 1.14 1.14 LOC647832 0.19 -0.34 0.81 1.15 0.00 1 2 3 4 5 1.14 1.14 TBX1 -0.39 -0.74 0.40 -0.97 -0.29 1 2 3 4 5 1.14 1.14 HS.389988 1.16 0.41 1.55 1.17 0.84 1 2 3 4 5 1.14 1.14 RNF139 -0.55 -0.61 0.53 -0.65 -0.08 1 2 3 4 5 1.14 1.14 LOC729249 -0.53 -1.25 -0.11 -0.47 -0.32 1 2 3 4 5 1.14 1.14 AQP4 0.48 -0.78 0.37 0.05 -0.68 1 2 3 4 5 1.14 1.14 C1QTNF9 4.73 -1.02 0.13 -0.55 0.94 1 2 3 4 5 1.14 1.14 HS.539414 0.57 -0.79 0.36 1.27 -0.10 1 2 3 4 5 1.14 1.14 CA3 -0.50 -0.20 0.94 0.77 2.12 1 2 3 4 5 1.14 1.14 LOC649296 -0.34 1.02 2.17 0.05 -0.73 1 2 3 4 5 1.14 1.14 NEU4 -0.70 -0.41 0.73 1.40 -0.30 1 2 3 4 5 1.14 1.14 HS.564015 -0.03 -0.11 1.03 -0.14 -0.08 1 2 3 4 5 1.14 1.14 HS.541304 -0.10 -0.08 1.06 0.01 0.07 1 2 3 4 5 1.14 1.14 Table 3 97 LOC651272 -0.03 0.11 1.25 0.05 -0.05 1 2 3 4 5 1.14 1.14 ST6GAL2 1.80 -0.17 0.97 1.13 0.23 1 2 3 4 5 1.14 1.14 FU35740 -0.17 -0.28 0.86 0.77 -0.10 1 2 3 4 5 1.14 1.14 HS.349073 -0.18; -1.09 0.04 0.28 -0.07 1 2 3 4 5 : 1.14 1.14 HS.541005 -0.11 1.04 2.18 -0.68 0.31 1 2 3 4 5 1.14 1.14 HS.545395 0.88 -0.36 0.78 -0.69 0.14 1 2 3 4 5 1.14 1.14 SYDE1 -0.75 -0.29 0.85 -1.24 0.72 1 2 3 4 5 1.14 1.14 LOC93556 5.30 2.40 3.54 -1.14 -1.24 1 2 3 4 5 1.14 1.14 HS.22495 0.61 -0.35 0.79 -0.20 0.97 1 2 3 4 5 1.14 1.14 PAPOLB -0.18 -0.32 0.81 -0.79 -0.12 1 2 3 4 5 1.14 1.14 HS.521548 0.50 -0.44 0.69 0.09 0.05 1 2 3 4 5 1.14 1.14 HS.554723 0.79 -1.14 -0.01 0.63 0.49 1 2 3 4 5 1.14 1.14 LOC643721 -0.77 0.31 1.45 -0.24 -0.10 1 2 3 4 5 1.14 1.14 LOC619208 -0.29 -0.14 0.99 0.01 0.78 1 2 3 4 5 1.14 1.14 HS.566881 -0.13 0.25 1.38 3.37 -0.02 1 2 3 4 5 1.14 1.14 SMR3B 0.10 -1.09 0.04 -1.13 -1.66 1 2 3 4 5 1.14 1.14 HS.540022 0.77 -0.12 1.02 0.07 -0.21 1 2 3 4 5 1.14 1.14 HS.570650 -0.57 -0.35 0.79 1.51 -0.08 1 2 3 4 5 1.14 1.14 MIP -1.37 -1.33 -0.19 4.88 1.24 1 2 3 4 5 1.14 1.14 LOC650180 0.03 0.98 2.12 0.51 1.02 1 2 3 4 5 1.13 1.13 HS.537859 0.48 -0.38 0.75 -0.11 0.64 1 2 3 4 5 1.13 1.13 XG -1.68 -0.06 1.07 1.23 2.79 1 2 3 4 5 1.13 1.13 FBXW12 -1.29 0.30 1.43 2.13 0.32 1 2 3 4 5 1.13 1.13 HS.542967 0.37 -0.50 0.64 -0.36 -0.02 1 2 3 4 5 1.13 1.13 HOXC9 -1.09 -0.21 0.92 -0.22 0.88 1 2 3 4 1.13 1.13 HS.554391 1.14 -0.94 0.20 2.22 -1.84 1 2 3 4 5 1.13 1.13 C10ORF25 0.34 -0.78 0.35 -0.43 1.78 1 2 3 4 5 1.13 1.13 KCTD1 -0.13 0.02 1.15 0.11 -0.11 1 2 3 4 5 1.13 1.13 NGFR -0.47 -0.69 0.44 -0.76 -0.37 1 2 3 4 5 1.13 1.13 HS.570736 -0.40 -0.68 0.45 -0.28 0.61 1 2 3 4 5 1.13 1.13 ERCC6L 4.06 -0.41 0.72 -0.05 -1.40 1 2 3 4 5 1.13 1.13 LOC650185 -0.05 0.02 1.15 0.05 -0.07 1 2 3 4 5 1.13 1.13 OR4D9 -0.31 -0.35 0.78 0.85 0.68 1 2 3 4 5 1.13 1.13 HS.97443 1.51 -1.43 -0.30 1.77 2.49 1 2 3 4 5 1.13 1.13 LOC388419 -0.53 -0.52 0.61 1.97 1.62 1 2 3 4 5 1.13 1.13 LOC643576 -0.75 -0.54 0.59 1.57 -0.32 1 2 3 4 5 1.13 1.13 LOC644954 0.06 1.58 2.71 0.02 -0.95 1 2 3 4 5 1.13 1.13 HS.543245 -0.54 -0.49 0.64 -0.67 -0.65 1 2 3 4 5 1.13 1.13 LACRT -0.30 -0.55 0.58 0.31 -0.87 1 2 3 4 5 1.13 1.13 HS.573368 -0.05 0.41 1.53 1.56 0.52 1 2 3 4 5 1.13 1.13 HS.360950 0.04 0.15 1.28 0.46 -0.11 1 2 3 4 5 1.13 1.13 HS.542865 -0.11 0.07 1.19 0.50 -0.07 1 2 3 4 5 1.13 1.13 HS.436308 -0.29 -0.23 0.90 -0.13 -0.25 1 2 3 4 5 1.13 1.13 LOC643783 -0.58 -0.26 0.87 -0.05 -0.31 1 2 3 4 5 1.13 1.13 PTPRS -0.02 -0.17 0.96 -0.13 -0.12 1 2 3 4 5 1.13 1.13 HS.575577 -0.70 -0.38 0.75 0.81 -0.01 1 2 3 4 5 1.12 1.12 OR13F1 -1.25 0.66 1.79 -0.83 -0.25 1 2 3 4 5 1.12 1.12 C60RF142 3.64 -0.22 0.90 0.15 2.74 1 2 3 4 5 1.12 1.12 SERPINB3 -0.71 -0.29 0.84 -0.23 -0.85 1 2 3 4 5 1.12 1.12 Table 3 98 C210RF123 -0.04 -0.63 0.49 -0.57 0.42 1 2 3 4 5 1.12 1.12 LOC643085 1.14 -1.18 -0.06 1.31 -0.44 1 2 3 4 5 1.12 1.12 HS.566785 -0.59 3.10 4.22 0.16 1.42 1 2 3 4 5 1.12 1.12 HS.572558 -0.14 -0.39 0.73 -0.05 -0.04 1 2 3 4 5 1.12 1.12 HS.282703 0.11 0.01 1.13 1.72 0.77 1 2 3 4 5 1.12 1.12 HS.566016 -0.07 0.00 1.13 -0.67 0.80 1 2 3 4 5 1.12 1.12 SLC9A11 0.35 0.08 1.20 -0.11 -0.37 1 2 3 4 5 1.12 1.12 CYP2B6 1.11 0.62 1.74 0.23 0.02 1 2 3 4 5 1.12 1.12 HS.582810 -0.32 0.42 1.54 -0.37 1.32 1 2 3 4 5 1.12 1.12 HS.583949 0.70 0.45 1.57 3.47 0.21 1 2 3 4 5 1.12 1.12 ClORFllO 1.47 -0.09 1.03 -1.03 -0.32 1 2 3 4 5 1.12 1.12 SLC1A1 -0.43 -0.29 0.83 0.34 -1.14 1 2 3 4 5 1.12 1.12 TRIM16L 2.92 -0.18 0.94 0.57 3.17 1 2 3 4 5 1.12 1.12 LOC646365 2.51 0.22 1.34 -0.40 0.56 1 2 3 4 5 1.12 1.12 EGFL8 -0.28 -0.85 0.27 0.75 -0.59 1 2 3 4 5 1.12 1.12 HS.552684 -0.47 -0.44 0.68 0.75 -0.28 1 2 3 4 5 1.12 1.12 HS.582910 1.01 0.39 1.51 -0.53 -0.74 1 2 3 4 1.12 1.12 LOC653380 0.67 -0.48 0.64 -0.21 0.74 1 2 3 4 5 1.12 1.12 LOC645882 -0.29 0.48 1.60 1.13 0.55 1 2 3 4 5 1.12 1.12 LOC652804 -1.25 -0.27 0.85 0.03 -0.49 1 2 3 4 5 1.12 1.12 HS.539868 1.41 1.83 2.95 -0.43 0.72 1 2 3 4 5 1.12 1.12 HS.582336 -0.15 -0.47 0.65 0.41 -0.85 1 2 3 4 5 1.12 1.12 RANBP3L -1.27 -0.56 0.55 1.92 -0.56 1 2 3 4 5 1.12 1.12 HS.568655 1.91 -0.59 0.53 -0.14 -1.75 1 2 3 4 5 1.12 1.12 HS.34882 2.22 0.98 2.09 -0.45 0.57 1 2 3 4 5 1.12 1.12 PKDREJ 0.66 -0.59 0.53 -0.67 -0.01 1 2 3 4 5 1.12 1.12 LOC651493 2.32! 0.28 1.40 1.04 -0.06 1 2 3 4 5 1.12 1.12 MBD3L2 0.84 0.20 1.32 0.02 0.36 1 2 3 4 5 1.12 1.12 HS.563501 -0.42 -0.41 0.70 -0.41 -0.73 1 2 3 4 5 1.12 1.12 OR51B2 -0.50 -0.32 0.79 -0.42 3.16 1 2 3 4 5 1.11 1.11 GSTT2 0.46 -0.08 1.04 0.27 0.06 1 2 3 4 1.11 1.11 HS.396491 0.45 0.14 1.25 -0.23 -0.40 1 2 3 4 5 1.11 1.11 IFNA5 -0.34 -1.04 0.07 -0.33 0.42 1 2 3 4 5 1.11 1.11 HS.541937 -0.59 1.73 2.84 -0.28 3.24 1 2 3 4 5 1.11 1.11 HS.543809 1.92 i .21 2.32 0.77 1.53 1 2 3 4 5 1.11 1.11 HS.566337 5.56 -0.37 0.74 0.51 -0.39 1 2 3 4 5 1.11 1.11 DIRAS1 -0.83 -0.82 0.29 -0.69 1.49 1 2 3 4 5 1.11 1.11 LOC643990 2.63 0.77 1.88 1.04 -0.64 1 2 3 4 5 1.11 1.11 GRIK1 -1.09 -0.81 0.30 -0.25 1.29 1 2 3 4 5 1.11 1.11 HS.213081 -0.62 -0.88 0.23 -0.52 -0.49 1 2 3 4 5 1.11 1.11 HS.355140 -0.70 0.09 1.20 -0.23 -0.99 1 2 3 4 5 1.11 1.11 HS.74052 0.96 -0.30 0.80 2.53 0.59 1 2 3 4 5 1.11 1.11 HS.554699 -0.43 -0.45 0.66 -0.56 -0.26 1 2 3 4 5 1.11 1.11 HS.495132 -0 .21 0.53 1.64 0.19 -0.30 1 2 3 4 5 1.11 1.11 HS.582545 0.70 0.51 1.62 -0.06 -0.25 1 2 3 4 5 1.11 1.11 LOC644532 1.21 -0.23 0.88 0.92 -0.13 1 2 3 4 5 1.11 1.11 FU44313 0.62 -0.38 0.73 -0.30 -0.26 1 2 3 4 5 1.11 1.11 IL1F5 2.72 -0.74 0.36 -0.23 -0.94 1 2 3 4 5 1.11 1.11 HS.578364 0.85 -0.87 0.23 -1.28 2.21 1 2 3 4 5 1.10 1.10 Table 3 99 LOC653286 -1.27 -0.38 0.72 2.26 -0.23 1 2 3 4 5 1.10 1.10 LOC345537 0.61 -0.39 0.72 1.36 -0.63 1 2 3 4 5 1.10 1.10 HS.542913 -1.14 -0.67 0.44 -0.49 0.07 1 2 3 4 5 1.10 1.10 HS.539406 -0.42 -0.48 0.62 1.37 -0.46 1 2 3 4 5 1.10 1.10 HS.580714 -0.26 -0.03 1.07 0.00 0.28 1 2 3 4 5 1.10 1.10 KCNK15 -0.58 -0.55 0.55 0.53 -0.23 1 2 3 4 5 1.10 1.10 HS.129410 1.83 -0.22 0.88 -0.50 -0.39 1 2 3 4 5 1.10 1.10 HS.368007 -0.14 0.31 1.41 0.07 -0.05 1 2 3 4 5 1.10 1.10 HS.437111 -0.23 -0.81 0.29 0.17 -1.07 1 2 3 4 5 1.10 1.10 HS.541302 -1.46 -1.39 -0.29 1.07 -0.67 1 2 3 4 5 1.10 1.10 HS.576446 -0.49 -0.21 0.89 1.94 0.85 1 2 3 4 5 1.10 1.10 SYT4 -0.70 1.04 2.14 -0.70 -0.50 1 2 3 4 5 1.10 1.10 WFIKKN2 -1.15 -0.86 0.24 1.73 3.16 1 2 3 4 5 1.10 1.10 SGCG -1.03 -1.31 -0.21 0.24 0.70 1 2 3 4 5 1.10 1.10 KRTAP4-4 -0.41 -1.02 0.08 -0.58 0.61 1 2 3 4 5 1.10 1.10 HS.543117 0.02 -0.59 0.51 -0.47 4.10 1 2 3 4 5 1.10 1.10 LOC648689 -0.09 -0.17 0.93 -0.26 -0.11 1 2 3 4 5 1.10 1.10 HS.28367 0.00 0.21 1.30 0.32 0.19 1 2 3 4 5 1.10 1.10 OR52A4 2.09 -0.18 0.92 -0.34 -0.32 1 2 3 4 5 1.10 1.10 TMEM16C 0.37 -1.22 -0.12 1.31 1.32 1 2 3 4 5 1.10 1.10 PR0KR2 0.46 0.71 1.80 -0.51 0.18 1 2 3 4 5 1.10 1.10 MYL7 -0.48 -0.68 0.41 0.21 -0.29 1 2 3 4 5 1.10 1.10 HS.565872 0.77 -2.04 -0.94 0.25 0.04 1 2 3 4 5 1.10 1.10 HS. 145 162 1.79 -0.22 0.88 0.25 1.12 1 2 3 4 5 1.09 1.09 C10RF194 0.19 -0.38 0.71 0.33 2.44 1 2 3 4 5 1.09 1.09 HS.572735 -0.02 0.03 1.12 -0.06 -0.07 1 2 3 4 5 1.09 1.09 HS.584502 0.30 -0.41 0.68 -0.17 -1.01 1 2 3 4 5 1.09 1.09 PCP4L1 -0.72 -0.44 0.65 0.76 0.90 1 2 3 4 5 1.09 1.09 C160RF71 -0.21 -0.47 0.63 0.93 0.56 1 2 3 4 5 1.09 1.09 TIGD3 -0.48 -0.20 0.89 -0.25 -0.33 1 2 3 4 5 1.09 1.09 FAM71C 0.20 0.16 1.26 0.19 -0.21 1 2 3 4 5 1.09 1.09 HS.544482 -0.35 0.82 1.92 -0.03 -0.11 1 2 3 4 5 1.09 1.09 SERPINA3 -0.37 -0.23 0.87 -1.00 1.07 1 2 3 4 5 1.09 1.09 CCL27 -0.59 -0.53 0.56 0.63 0.51 1 2 3 4 5 1.09 1.09 HS.553187 3.02 -0.65 0.44 -0.84 -1.21 1 2 3 4 5 1.09 1.09 HS.517252 -0.27 -0.60 0.49 -0.54 0.16 1 2 3 4 5 1.09 1.09 C150RF33 -0.28 0.63 1.72 -0.52 -0.37 1 2 3 4 5 1.09 1.09 PR0M2 -0.18 -0.18 0.91 -0.22 -0.08 1 2 3 4 5 1.09 1.09 HS.516209 -0.63 -0.06 1.03 0.31 2.72 1 2 3 4 5 1.09 1.09 C21ORF90 -0.34 0.22 1.31 0.09 0.14 1 2 3 4 5 1.09 1.09 HS.538566 -0.22 -0.19 0.89 -0.32 -0.25 1 2 3 4 5 1.09 1.09 GYP2W1 0.70 -0.98 0.10 1.25 3.52 1 2 3 4 · 5 1.09 1.09 HS.578900 -0.40 -0.22 0.87 0.18 -0.38 1 2 3 4 5 1.09 1.09 0R13J1 -0.47 -1.17 -0.08 0.09 3.19 1 2 3 4 5 1.09 1.09 LOC644680 -0.63 -0.48 0.61 3.02 0.82 1 2 3 4 5 1.09 1.09 HS.538747 -0.12 -0.06 1.03 0.70 -0.18 1 2 3 4 5 1.09 1.09 VANGL2 -0.41 -0.19 0.89 -0.43 -0.49 1 2 3 4 5 1.09 1.09 LOC645073 0.58 -0.13 0.95 -0.37 -0.22 1 2 3 4 5 1.09 1.09 HS.540415 -0.07 -0.18 0.90 0.74 1.19 1 2 3 4 5 1.09 1.09 Table 3 100 HS.434134 -0.29 0.14 1.23 -0.49 -0.26 1 2 3 4 5 1.09 1.09 MFAP2 -0.92 -0.98 0.11 0.09 -0.46 1 2 3 4 5 1.09 1.09 LOC651287 0.02 -0.36 0.72 -0.07 0.85 1 2 3 4 5 1.09 1.09 PCSK1N -0.07 0.03 1.12 0.08 0.09 1 2 3 4 5 1.09 1.09 HS.541957 -0.05 -0.18 0.91 -0.17 0.06 1 2 3 4 5 1.09 1.09 HS.551093 -0.22 -0.06 1.02 -0.38 1.34 1 2 3 4 5 1.08 1.08 HS.569253 1.15 -0.03 1.05 -0.30 0.41 1 2 3 4 5 1.08 1.08 LOC347487 0.98 -0.17 0.91 -0.34 2.89 1 2 3 4 5 1.08 1.08 LHX2 -0.58 -0.09 0.99 -0.55 -0.46 1 2 3 4 5 1.08 1.08 TCN1 -0.33 -0.64 0.45 -0.22 -0.04 1 2 3 4 5 1.08 1.08 0R2L1P 0.96 1.19 2.27 1.17 -1.01 1 2 3 4 5 1.08 1.08 LOC650256 0.23 -0.82 0.26 -0.47 0.23 1 2 3 4 5 1.08 1.08 HS.551272 -0.01 -0.33 0.75 0.17 1.97 1 2 3 4 5 1.08 1.08 HS.298112 2.65 0.06 1.14 3.94 -0.52 1 2 3 4 5 1.08 1.08 GRIN1 -0.56 -0.50 0.58 0.78 -0.24 1 2 3 4 5 1.08 1.08 DUSP15 -0.58 0.06 1.14 0.11 -0.37 1 2 3 4 5 1.08 1.08 ENPEP 0.12 -0.93 0.16 1.29 0.33 1 2 3 4 5 1.08 1.08 CSAG2 -1.34 -1.19 -0.11 1.42 0.08 1 2 3 4 5 1.08 1.08 INS-IGF2 -0.01 -1.31 -0.23 -0.96 -0.95 1 2 3 4 5 1.08 1.08 HS.543791 -0.69 0.37 1.45 -0.72 -0.44 1 2 3 4 5 1.08 1.08 PRAMEF21 0.17 0.08 1.16 0.43 0.66 1 2 3 4 5 1.08 1.08 HS.565580 -0.28 -0.52 0.56 0.53 -0.37 1 2 3 4 5 1.08 1.08 HS.542778 0.75 -0.47 0.61 -1.32 -0.80 1 2 3 4 5 1.08 1.08 HS.502618 0.71 -1.36 -0.28 3.08 -0.70 1 2 3 4 5 1.08 1.08 HS.485241 0.00 -0.41 0.67 0.56 0.30 1 2 3 4 5 1.08 1.08 HS.563680 -0.38 -0.64 0.44 -0.24 -0.54 1 2 3 4 5 1.08 1.08 HS.538212 0.11 -1.03 0.05 -0.42 0.69 1 2 3 4 5 1.08 1.08 MBL1P1 0.08 -0.04 1.04 0.12 -0.04 1 2 3 4 5 1.08 1.08 OR4D2 0.64 -0.22 0.86 0.84 0.09 1 2 3 4 5 1.08 1.08 HS.570095 -0.63 -0.02 1.05 -0.83 -0.43 1 2 3 4 5 1.08 1.08 TKTL2 -0.95 -0.94 0.13 2.55 -1.23 1 2 3 4 5 1.08 1.08 HS.171204 0.97 -0.83 0.24 -0.91 -1.32 1 2 3 4 5 1.07 1.07 SFRP5 1.51 -0.10 0.97 1.57 -0.56 1 2 3 4 5 1.07 1.07 LOC646109 0.31 -0.56 0.51 -0.63 -0.34 1 2 3 4 5 1.07 1.07 SLC05A1 0.10 0.18 1.25 0.15 2.59 1 2 3 4 5 1.07 1.07 LOC732387 0.23 0.08 1.15 -0.15 0.94 1 2 3 4 5 1.07 1.07 HS.92993 ' -0.33 -0.32 0.75 -0.17 -0.14 1 2 3 4 5 1.07 1.07 HS.345154 -0.53 -0.63 0.44 -0.39 -0.21 1 2 3 4 5 1.07 1.07 HS.543096 -0.01 -0.16 0.92 0.22 -0.09 1 2 3 4 5 1.07 1.07 HS.582717 -0.88 -0.80 0.27 0.62 -0.06 1 2 3 4 5 1.07 1.07 HS.545006 -1.40 -0.11 0.96 -0.73 -0.65 1 2 3 4 1.07 . 1.07 HS.157866 0.36 -0.28 0.79 0.34 -0.21 1 2 3 4 5 1.07 1.07 LOC652046 -0.54 -0.05 1.02 -0.08 -1.00 1 2 3 4 5 1.07 1.07 SLC7A11 5.84 0.02 1.09 0.88 -0.39 1 2 3 4 5 1.07 1.07 ZNF409 0.45 -0.59 0.48 0.79 1.18 1 2 3 4 5 1.07 1.07 HS.571249 0.41 0.37 1.44 -0.09 0.71 1 2 3 4 5 1.07 1.07 HS.438375 -0.39 -0.80 0.27 -0.37 -0.45 1 2 3 4 5 1.07 1.07 HS.576807 -0.89 1.13 2.20 -1.03 -0.18 1 2 3 4 5 1.07 1.07 LOC643697 0.44 -0.18 0.89 -0.08 -0.38 1 2 3 4 5 1.07 1.07 Table 3 101 HS.571321 -0.45 -0.24 0.83 -0.06 -0.32 1 2 3 4 5 1.07 1.07 TSGA13 0.08 -0.23 0.84 -0.76 1.02 1 2 3 4 5 1.07 1.07 SOX2 2.58 0.23 1.30 1.09 -0.62 1 2 3 4 5 1.07 1.07 HS.132669 0.56 0.45 1.52 -0.48 2.02 1 2 3 4 5 1.07 1.07 HS.562777 -0.19 -0.79 0.28 1.03 -0.96 1 2 3 4 5 1.07 1.07 DYX1C1 -0.43 -0.54 0.52 -0.40 -0.75 1 2 3 4 5 1.07 1.07 LOC653249 0.13 0.21 1.28 1.04 2.06 1 2 3 4 5 1.07 1.07 KCNG4 1.42 2.38 3.45 3.51 6.19 1 2 3 4 5 1.07 1.07 LOC646550 -0.29 -0.43 0.63 -0.15 0.48 1 2 3 4 5 1.07 1.07 HS.128288 1.48 0.20 1.26 -0.82 3.77 1 2 3 4 5 1.07 1.07 KAZALD1 0.71 -1.03 0.04 -0.18 1.04 1 2 3 4 5 1.07 1.07 HS.438246 2.15 0.09 1.15 0.75 0.48 1 2 3 4 5 1.07 1.07 HS.443670 -0.12 -0.06 1.01 1.42 0.80 1 2 3 4 5 1.07 1.07 FAM58B -0.10 0.15 1.21 -0.08 1.61 1 2 3 4 5 1.07 1.07 HS.542184 0.32 -0.18 0.88 -0.59 0.39 1 2 3 4 5 1.07 1.07 HS.158564 2.02 -0.59 0.47 0.23 -0.16 1 2 3 4 5 1.07 1.07 S0X18 -0.25 -0.45 0.61 -0.22 0.09 1 2 3 4 5 1.06 1.06 LOC649856 -0.39 -0.03 1.04 0.00 -0.19 1 2 3 4 5 1.06 1.06 HS.244341 0.95 -0.11 0.95 2.29 0.16 1 2 3 4 5 1.06 1.06 HS.543628 0.10 -0.30 0.77 -0.65 1.00 1 2 3 4 1.06 1.06 LOC647850 0.42 0.23 1.29 0.18 0.07 1 2 3 4 5 1.06 1.06 ADAMTS8 -0.36 -0.49 0.58 0.00 0.46 1 2 3 4 5 1.06 1.06 HS.540000 -0.05 0.03 1.09 -0.01 -0.02 1 2 3 4 5 1.06 1.06 HS.368354 1.42 0.50 1.56 1.61 0.63 1 2 3 4 5 1.06 1.06 HS.565559 0.49 0.01 1.07 0.17 -0.13 1 2 3 4 5 1.06 1.06 CNIH3 -0.17 -0.43 0.64 -0.04 -0.55 1 2 3 4 5 : 1.06 1.06 HS.545769 -0.57 -0.31 0.75 -0.21 2.80 1 2 3 4 5 1.06 1.06 IFNA16 1.24 -0.59 0.47 0.95 0.58 1 2 3 4 5 1.06 1.06 SYP -0.43 -0.65 0.42 -0.92 -0.85 1 2 3 4 5 1.06 1.06 HS.577260 0.76 1.54 2.60 -0.28 1.16 1 2 3 4 5 1.06 1.06 HS.364555 0.02 -0.64 0.42 -0.30 -0.71 1 2 3 4 5 1.06 1.06 HS.568528 -0.48 -0.34 0.72 -0.51 -0.67 1 2 3 4 5 ; 1.06 1.06 AADACL4 0.75 -0.68 0.38 2.35 1.08 1 2 3 4 5 1.06 1.06 LOC732157 -0.04 0.41 1.47 0.27 0.08 1 2 3 4 5 1.06 1.06 LOC284948 0.21 -0.22 0.84 0.05 -0.15 1 2 3 4 5 1.06 1.06 LOC400968 -0.29 -0.29 0.76 1.17 1.30 1 2 3 4 5 1.06 1.06 HS.522935 -0.37 -0.22 0.84 0.97 0.63 1 2 3 4 5 1.06 1.06 TCF21 0.73 -1.14 -0.08 0.44 -0.85 1 2 3 4 5 1.06 1.06 VIPR2 -0.30 -0.02 1.04 1.56 1.43 1 2 3 4 5 1.06 1.06 S100G 3.62 0.45 1.51 -0.97 0.28 1 2 3 4 5 1.06 1.06 HS.580417 -0.05 -0.18 0.87 0.02 -0.22 1 2 3 4 5 1.06 1.06 MYLK3 0.89 -1.09 -0.04 -0.56 -0.50 1 2 3 4 5 1.06 1.06 HS.541520 0.10 0.13 1.19 0.31 1.03 1 2 3 4 5 1.06 1.06 CDC42EP5 0.40 0.16 1.21 -0.49 0.37 1 2 3 4 5 1.06 1.06 HS.116405 -0.44 -0.78 0.28 0.01 -0.21 1 2 3 4 5 1.06 1.06 PDCD1LG2 -1.74 -3.02 -1.97 3.10 -1.41 1 2 3 4 5 1.06 1.06 LOC651410 0.23 0.03 1.09 0.36 4.00 1 2 3 4 5 1.06 1.06 LOC391209 -0.37 -0.35 0.71 -0.49 -0.65 1 2 3 4 5 1.05 1.05 HS.580662 0.07 -0.43 0.63 -0.28 0.04 1 2 3 4 5 1.05 1.05 Table 3 102

UBE2NL 0.23 -0.62 0.43 0.37 0.61 1 2 3 4 5 1.05 1.05 PPP3R2 -0.45 -0.38 0.67 -0.25 0.32 1 2 3 4 5 1.05 1.05 HS.579045 1.04 0.10 1.15 0.92 -0.17 1 2 3 4 5 1.05 1.05 HS.540063 -0.45 0.80 1.85 0.43 1.31 1 2 3 4 5 1.05 1.05 AMOTL1 -0.02 0.17 1.22 1.77 0.18 1 2 3 4 5 1.05 1.05 ENAM 2.39 0.08 1.13 0.50 0.55 1 2 3 4 5 1.05 1.05 OR51F1 1.16 -0.51 0.54 -0.32 -0.12 1 2 3 4 5 1.05 1.05 HS.196114 1.92 -0.52 0.53 -0.48 1.92 1 2 3 4 5 1.05 1.05 WDR69 0.09 -0.37 0.68 -0.36 1.80 1 2 3 4 5 1.05 1.05 DBX1 -0.40 -0.79 0.26 -0.18 -0.05 1 2 3 4 5 1.05 1.05 HS.545163 -0.24 -0.28 0.77 -0.35 0.93 1 2 3 4 5 1.05 1.05 LOC644298 0.03 -0.78 0.27 0.16 -0.12 1 2 3 4 5 1.05 1.05 HS.546494 0.72 -0.31 0.74 0.49 -0.92 1 2 3 4 5 1.05 1.05 HS.128309 -0.39 -0.31 0.74 0.05 -0.13 1 2 3 4 5 1.05 1.05 HS.534976 -0.44 -0.47 0.58 0.90 0.07 1 2 3 4 5 1.05 1.05 FBXL21 0.05 -0.17 0.88 0.06 0.02 1 2 3 4 5 1.05 1.05 KCNB1 -1.07 -0.67 0.38 -0.73 0.18 1 2 3 4 5 1.05 1.05 CDCA1 -0.60 -0.17 0.88 -0.42 1.93 1 2 3 4 5 1.05 1.05 PLA2G1B 1.42 1.68 2.73 1.04 0.07 1 2 3 4 5 1.05 1.05 LOC650861 1.12 0.03 1.08 -0.77 -0.75 1 2 3 4 5 1.05 1.05 HS.579532 1.09 0.03 1.08 0.22 0.33 1 2 3 4 5 1.05 1.05 LOC652606 -0.20 -0.67 0.38 0.57 -0.48 1 2 3 4 5 1.05 1.05 HS.370039 2.24 0.14 1.18 0.19 1.02 1 2 3 4 5 1.05 1.05 LOC645302 0.21 -0.76 0.29 0.61 0.83 1 2 3 4 5 1.05 1.05 HS.565027 -0.61 -0.60 0.44 1.20 1.18 1 2 3 4 5 ; 1.05 1.05 HS.579351 -0.31 -0.31 0.74 -0.03 -0.16 1 2 3 4 5 1.05 1.05 GABRR1 1.40 -0.94 0.10 -0.82 2.82 1 2 3 4 5 1.05 1.05 HS.569542 -0.31 -0.38 0.66 0.10 -0.20 1 2 3 4 5 1.04 1.04 LOC389722 0.15 -0.38 0.67 1.87 -0.21 1 2 3 4 5 1.04 1.04

CLDN6 -0.07 0.09 1.13 -0.53 1.33 1 2 3 4 5 i 1.04 1.04

POU3F1 0.82 0.39 1.43 -0.11 2.04 1 2 3 4 5 : 1.04 1.04 FAM19A3 1.10 -0.60 0.44 -1.05 -1.71 1 2 3 4 5 1.04 1.04 LOC650174 -0.39 -0.34 0.71 -0.04 0.15 1 2 3 4 5 1.04 1.04 FU35894 1.70 -0.70 0.34 1.39 0.94 1 2 3 4 5 1.04 1.04 HTR7P -0.57 -0.99 0.05 -0.43 0.11 1 2 3 4 5 1.04 1.04 HSPC072 -0.17 0.96 2.01 -1.07 0.03 1 2 3 4 5 1.04 1.04 LOC151121 -0.32 -0.46 0.58 -0.87 2.13 1 2 3 4 5 1.04 1.04 LOC644065 -0.77 -0.89 0.15 0.76 0.12 1 2 3 4 1.04 1.04 HS.578471 -0.37 -0.45 0.59 0.14 -0.57 1 2 3 4 5 1.04 1.04 LOC285307 0.58 -0.29 0.76 -0.09 -0.24 1 2 3 4 1.04 1.04 LOC645992 -1.42 0.02 1.07 2.16 1.12 1 2 3 4 5 1.04 1.04 PTH2 1.07 1.01 2.05 1.20 0.85 1 2 3 4 5 1.04 1.04 SPATA9 0.40 -0.05 0.99 -0.10 -0.25 1 2 3 4 5 1.04 1.04 EN2 -0.67 -0.56 0.48 0.48 -0.68 1 2 3 4 5 1.04 1.04 HS.565878 -0.17 0.56 1.60 1.54 3.93 1 2 3 4 5 1.04 1.04 HOXC13 -0.34 -0.65 0.39 0.15 -0.42 1 2 3 4 5 1.04 1.04 HS.533844 -0.51 -0.37 0.67 -0.13 0.02 1 2 3 4 5 1.04 1.04 C20ORF144 2.04 -0.25 0.79 0.09 -0.67 1 2 3 4 5 1.04 1.04 GPR111 -1.74 -1.67 -0.63 0.45 2.15 1 2 3 4 5 1.04 1.04 Table 3 103 LOC653507 -0.78 -0.73 0.31 0.10 1.00 1 2 3 4 5 1.04 1.04 HIST1H2BL 0.24 0.57 1.61 0.04 -0.26 1 2 3 4 5 1.04 1.04 HS.278948 4.51 -0.26 0.78 -0.79 3.65 1 2 3 4 5 1.04 1.04 HS.125672 -0.78 -1.74 -0.70 -1.38 -0.26 1 2 3 4 5 1.04 1.04 HS.512359 0.84 -1.10 -0.06 0.73 0.76 1 2 3 4 5 1.04 1.04 OR2T4 1.10 -1.09 -0.05 1.82 -0.65 1 2 3 4 5 1.04 1.04 DEFB136 -1.32 -0.77 0.27 1.04 0.24 1 2 3 4 5 1.04 1.04 LOC402643 1.60 -0.40 0.64 0.52 0.89 1 2 3 4 1.04 1.04 HS.127857 -0.20 0.06 1.10 0.06 -0.36 1 2 3 4 5 1.04 1.04 C20ORF39 -0.26 -0.27 0.77 0.83 -0.60 1 2 3 4 5 1.04 1.04 HS.452789 0.90 -0.46 0.58 3.44 -0.32 1 2 3 4 5 1.04 1.04 UMOD -0.39 -0.59 0.45 0.05 -0.30 1 2 3 4 5 1.04 1.04 MAGEA10 0.80 0.21 1.25 0.71 0.57 1 2 3 4 5 1.04 1.04 HS.564302 -0.86 0.66 1.70 1.36 1.23 1 2 3 4 5 1.04 1.04 LOC650977 -0.18 0.23 1.27 0.38 0.80 1 2 3 4 5 1.04 1.04 HS.48903 0.25 0.83 1.86 -0.81 2.05 1 2 3 4 5 1.03 1.03 COL5A3 1.34 -0.72 0.32 -0.92 -0.43 1 2 3 4 5 1.03 1.03 HS.545732 0.27 -0.15 0.89 -0.66 0.04 1 2 3 4 5 1.03 1.03 HS.274228 -0.14 0.77 1.80 -0.24 -0.23 1 2 3 4 5 1.03 1.03 HS.545697 -1.01 -0.83 0.20 -1.07 1.81 1 2 3 4 5 1.03 1.03 HS.537747 -0.64 0.51 1.54 1.06 -0.96 1 2 3 4 5 1.03 1.03 HS.573025 0.09 0.23 1.26 -0.23 -0.13 1 2 3 4 5 1.03 1.03 HS.510641 -1.06 -0.79 0.24 3.24 -0.14 1 2 3 4 5 1.03 1.03 C10RF158 0.14 -0.98 0.05 -0.36 -0.58 1 2 3 4 5 1.03 1.03 SCN5A 0.67 -0.19 0.85 0.79 0.50 1 2 3 4 5 1.03 1.03 HS.575344 -0.29 -0.75 0.28 -0.87 -0.47 1 2 3 4 5 1.03 1.03 LOC646582 0.15 0.67 1.70 -0.68 -0.43 1 2 3 4 5 1.03 1.03 LOC648608 -0.16; -0.25 0.78 -0.09 0.16 1 2 3 4 5 1.03 1.03 CACNG5 -0.17 -0.88 0.14 0.50 -0.29 1 2 3 4 5 1.03 1.03 TGM3 -O.35 -0.23 0.80 0.17 0.19 1 2 3 4 5 1.03 1.03 HS.581442 -0.41 -0.28 0.75 1.83 -0.21 1 2 3 4 5 1.03 1.03 HS.573904 0.84 -0.09 0.94 -0.06 0.55 1 2 3 4 5 1.03 1.03 HS.560292 -0.37 -0.65 0.37 -1.04 -0.41 1 2 3 4 5 1.03 1.03 SLC4A3 -0.48 -0.29 0.74 -0.19 -0.40 1 2 3 4 5 1.03 1.03 OR2D2 -0.89 -0.10 0.93 -0.22 -0.52 1 2 3 4 5 1.03 1.03 TAAR9 0.00 -0.39 0.64 0.21 0.51 1 2 3 4 5 1.03 1.03 HS.261568 0.64 -0.43 0.59 0.44 -0.10 1 2 3 4 5 1.03 1.03 HS.575696 -0.25 -0.51 0.51 0.24 -0.37 1 2 3 4 5 1.03 1.03 LOC645682 1.26 0.04 1.07 -0.24 0.16 1 2 3 4 5 1.03 1.03 IRX2 0.55 -0.30 0.73 2.53 -1.08 1 2 3 4 5 1.03 1.03 HS.550390 -0.66 -1.44 -0.42 -1.43 -1.06 1 2 3 4 5 1.03 1.03 HS.577393 -0.30 -0.02 - 1.00 -0.78 -0.10 1 2 3 4 5 1.03 1.03 GLDN 1.50 -1.76 -0.73 -2.05 -0.43 1 2 3 4 5 1.03 1.03 HS.573972 -0.20 1.03 2.06 0.01 0.10 1 2 3 4 5 1.03 1.03 LOC644388 -0.07 -0.40 0.63 0.64 0.20 1 2 3 4 5 1.03 1.03 DUX4C 0.62 -0.30 0.72 -0.35 -0.26 1 2 3 4 5 1.03 1.03 HS.172577 -0.61 -0.69 0.33 0.17 0.18 1 2 3 4 5 1.03 1.03 HS.149058 -0.01 -0.31 0.71 1.73 0.36 1 2 3 4 5 1.03 1.03 HS.447469 -0.38 1.22 2.24 -0.23 0.07 1 2 3 4 5 1.03 1.03 Table 3 104 HS.515186 -0.14 -0.51 0.52 0.39 -0.25 1 2 3 4 5 1.03 1.03 OR8K1 0.00 -0.41 0.62 -0.12 1.13 1 2 3 4 5 1.03 1.03 GNRHR2 -0.47 -0.93 0.09 -0.58 -0.33 1 2 3 4 5 1.02 1.02 C50RF38 -0.50 -0.61 0.41 2.32 -0.69 1 2 3 4 1.02 1.02 DIRAS2 0.18 0.06 1.09 1.39 0.26 1 2 3 4 5 1.02 1.02 OR10AG1 3.18 -0.79 0.23 0.78 -0.09 1 2 3 4 5 1.02 1.02 FU44076 0.77 -0.25 0.77 0.01 -0.13 1 2 3 4 5 1.02 1.02 HS.554592 -0.15 -0.18 0.84 -0.25 -0.21 1 2 3 4 5 1.02 1.02 HS.543517 0.77 -0.35 0.67 -0.42 -0.28 1 2 3 4 5 1.02 1.02 HS.540475 0.22 -0.17 0.85 0.33 -0.14 1 2 3 4 5 1.02 1.02 RBMS3 -1.16 -0.74 0.29 -0.23 -1.40 1 2 3 4 5 1.02 1.02 LOC651694 0.11 0.07 1.09 -0.28 -0.51 1 2 3 4 5 1.02 1.02 HS.147867 -0.54 0.24 1.26 -0.13 0.40 1 2 3 4 5 1.02 1.02 KCTD8 -0.37 -0.58 0.44 -0.26 0.17 1 2 3 4 5 1.02 1.02 C110RF39 -1.29 -0.45 0.58 0.70 0.51 1 2 3 4 5 1.02 1.02 SLC4A9 1.62 -0.46 0.56 -1.41 0.34 1 2 3 4 5 1.02 1.02 LOC652849 -0.24 0.09 1.11 -0.22 -0.27 1 2 3 4 5 1.02 1.02 LOC652805 -0.23 -0.02 1.00 -0.47 -0.41 1 2 3 4 5 1.02 1.02 LOC643334 O.I2! -0.49 0.52 0.42 -0.29 1 2 3 4 5 1.02 1.02 ERVK6 -0.59 -0.24 0.77 -0.14 0.76 1 2 3 4 5 1.02 1.02 LOC646796 -0.35; -0.60 0.41 -0.49 -0.55 1 2 3 4 5 1.02 1.02 LOC644336 0.64 -0.36 0.66 0.84 -0.27 1 2 3 4 5 1.02 1.02 HS.547695 0.95; -1.06 -0.04 4.30 -0.26 1 2 3 4 5 1.02 1.02 SPEM1 0.19 -0.26 0.76 0.84 4.07 1 2 3 4 5 1.02 1.02 HS.260074 0.08: -0.54 0.48 0.30 0.19 1 2 3 4 5 1.02 1.02 HS.564723 0.43; 0.05 1.07 0.04 1.57 1 2 3 4 5 1.02 1.02 HS.554643 0.22 0.20 1.21 0.51 -0.43 1 2 3 4 5 1.02 1.02 HS.244783 0.14 -0.39 0.63 -0.66 -0.87 1 2 3 4 5 1.02 1.02 LOC647336 -0.13; 0.32 1.34 1.07 1.84 1 2 3 4 5 1.02 1.02 C20ORF112 -0.09 -0.63 0.39 -0.33 -0.65 1 2 3 4 5 1.02 1.02 HS.539010 -0.09^ 0.46 1.48 0.63 0.42 1 2 3 4 5 1.02 1.02 PVRL4 -0.12; 0.93 1.94 -0.26 3.06 1 2 3 4 5 1.02 1.02 FERMT2 0.36 -0.46 0.55 0.57 0.40 1 2 3 4 5 1.02 1.02 HS.574973 0.46 0.03 1.04 0.60 -0.50 1 2 3 4 5 1.02 1.02 TRI 43 -0.89 -0.59 0.42 -0.53 2.06 1 2 3 4 5 1.01 1.01 GFRA3 0.22 -0.65 0.37 -0.49 0.28 1 2 3 4 5 1.01 1.01 HS.179715 0.67 -0.42 0.60 0.29 2.85 1 2 3 4 5 1.01 1.01 LOC650668 -1.16 0.01 1.02 0.80 1.21 1 2 3 4 5 1.01 1.01 LOC651249 -0.84 1.53 2.54 -0.03 -0.72 1 2 3 4 5 1.01 1.01 TXNDC6 -0.62 -0.50 0.51 1.05 -0.50 1 2 3 4 5 1.01 1.01 HS.567054 1.44 0.25 1.26 0.62 0.31 1 2 3 4 5 1.01 1.01 HS.565941 0.08 -0.41 0.60 -0.15 0.27 1 2 3 4 5 1.01 1.01 HS.566344 0.60 -0.05 0.96 0.09 0.58 1 2 3 4 5 1.01 1.01 HS.245751 2.32 -0.46 0.55 -0.40 0.08 1 2 3 4 5 1.01 1.01 KRTAP5-4 -0.05 -1.35 -0.34 1.40 0.04 1 2 3 4 5 1.01 1.01 HS.137098 1.36 1.27 2.28 3.32 2.03 1 2 3 4 5 1.01 1.01 HS.538025 1.09 -0.59 0.42 -0.82 -0.40 1 2 3 4 5 1.01 1.01 LOC646241 1.71 0.84 1.85 0.73 1.19 1 2 3 4 5 1.01 1.01 FERD3L 0.54 0.14 1.15 -0.35 0.01 1 2 3 4 5 1.01 1.01 Table 3 105

OR6C74 -1.01 -0.91 0.10 -1.47 0.02 1 2 3 4 5 1.01 1.01 HS.266571 0.82 -0.69 0.32 -0.41 0.73 1 2 3 4 5 1.01 1.01 LOC145845 -0.40 -0.40 0.61 -0.49 1.52 1 2 3 4 5 1.01 1.01 ADAMTS12 2.24 -0.37 0.64 -0.42 -1.10 1 2 3 4 5 1.01 1.01 HS.97104 0.98 0.18 1.19 0.98 1.30 1 2 3 4 5 1.01 1.01 LOC653254 1.11 -0.51 0.50 -0.67 1.14 1 2 3 4 5 1.01 1.01 LOC390705 -0.16 -0.18 0.83 0.27 0.11 1 2 3 4 5 1.01 1.01 HS.558027 -0.09 -0.22 0.79 -0.20 0.91 1 2 3 4 5 1.01 1.01 LOC643920 -1.18 -0.76 0.25 3.76 -1.24 1 2 3 4 5 1.01 1.01 HS.575479 0.17 0.33 1.34 0.50 -0.07 1 2 3 4 5 1.01 1.01 TNN -1.10 -1.02 -0.02 -0.88 -0.19 1 2 3 4 5 1.01 1.01 HS.547735 -0.30 0.04 1.05 0.41 0.66 1 2 3 4 5 1.01 1.01 HS.545073 3.30 -0.90 0.11 2.04 1.28 1 2 3 4 5 1.01 1.01 HS.584392 2.97 0.03 1.04 0.38 -0.04 1 2 3 4 5 1.00 1.00 LOC390760 -0.32 -0.97 0.03 -0.70 -0.52 1 2 3 4 5 1.00 1.00 LOC645487 0.30 -0.11 0.89 -0.13 -0.27 1 2 3 4 - 5 1.00 1.00 HS.561339 0.95 -0.62 0.38 1.59 0.86 1 2 3 4 5 1.00 1.00 OR10P1 2.24 -0.69 0.32 0.53 0.39 1 2 3 4 5 1.00 1.00 CACNB4 0.99 -0.56 0.45 -0.85 0.44 1 2 3 4 5 1.00 1.00 PGPEP1 -0.12 -0.08 0.92 -0.31 -0.22 1 2 3 4 5 1.00 1.00 HS.539582 -0.48 0.15 1.16 0.94 0.76 1 2 3 4 5 1.00 1.00 HS.121410 0.14 0.31 1.31 0.05 0.21 1 2 3 4 5 1.00 1.00 LOC400879 -0.21 0.05 1.05 0.21 0.15 1 2 3 4 5 1.00 1.00 HS.539497 0.05 -0.08 0.92 0.23 -0.16 1 2 3 4 5 1.00 1.00 LOC129881 -0.09 -0.37 0.63 -0.11 -0.19 1 2 3 4 5 1.00 1.00 HS.577925 0.41 -0.68 0.32 0.18 -1.39 1 2 3 4 5 1.00 1.00 ATP 12A -0.26 -0.22 0.78 -0.09 -0.28 1 2 3 4 5 1.00 1.00 HS.550166 -0.03 -0.28 0.72 0.24 -0.12 1 2 3 4 5 1.00 1.00 TM4SF4 -0.11 -0.53 0.47 0.38 0.49 1 2 3 4 5 1.00 1.00 LOC647366 -0.58 -0.60 0.40 3.10 1.66 1 2 3 4 5 1.00 1.00 HS.582502 -0.21 0.28 1.28 3.11 1.93 1 2 3 4 5 1.00 1.00 HS.256252 0.23 -0.21 0.79 1.71 0.73 1 2 3 4 5 1.00 1.00 OR6K6 1.80 -0.46 0.53 0.20 0.38 1 2 3 4 5 1.00 1.00 HS.101773 -0.24 -0.05 0.94 0.18 -0.20 1 2 3 4 5 1.00 1.00 HS.554671 0.05 -0.11 0.89 0.20 0.42 1 2 3 4 5 1.00 1.00 MRGPRF -0.39 -0.38 0.61 -0.18 -0.33 1 2 3 4 5 1.00 1.00 GPLD1 3.07 -0.86 0.14 0.05 -0.39 1 2 3 4 5 1.00 1.00 KANK1 0.03 -0.69 0.30 -0.63 -0.43 1 .2 3 4 5 1.00 1.00 TFEC 0.45 -0.44 0.55 -0.19 -0.72 1 2 3 4 5 1.00 1.00 A L2 0.72 -0.74 0.25 1.71 1.05 1 2 3 4 5 1.00 1.00 HS.443913 1.96 -0.74 0.26 1.82 -0.55 1 2 3 4 5 1.00 1.00 HS.560095 0.75 1.41 0.42 0.14 -0.05 1 2 3 4 5 -1.00 1.00 C60RF168 -0.25 0.12 -0.88 -1.13 0.15 1 2 3 4 5 -1.00 1.00 ESRRG 1.11 0.86 -0.14 1.43 -0.26 1 2 3 4 5 -1.00 1.00 SRL -0.46 1.00 0.00 -0.07 -0.23 1 2 3 4 5 -1.00 1.00 LOC389111 -0.21 0.71 -0.29 0.32 0.00 1 2 3 4 5 -1.00 1.00 OR4F21 -0.40 0.61 -0.38 -0.31 -0.43 1 2 3 4 5 -1.00 1.00 HS.562873 -0.72 1.54 0.54 -0.64 -0.02 1 2 3 4 5 -1.00 1.00 LOC642660 0.09 3.18 2.18 -0.01 -0.70 1 2 3 4 5 -1.00 1.00 Table 3 106 HS.34447 0.42 0.91 -0.08 -0.18 0.36 1 2 3 4 5 -1.00 1.00 HS.540526 -0.21 1.07 0.07 0.68 0.82 1 2 3 4 5 -1.00 1.00 LOC647965 -0.32 0.91 -0.09 -0.04 -0.22 1 2 3 4 5 -1.00 1.00 LOC646146 0.74 0.89 -0.11 -0.23 -0.43 1 2 3 4 5 -1.00 1.00 HS.565900 0.39 0.72 -0.28 1.99 0.11 1 2 3 4 5 -1.00 1.00 HS.542900 0.20 0.78 -0.22 -0.74 -0.05 1 2 3 4 5 -1.00 1.00 HS.564132 0.58 1.09 0.09 -0.16 0.50 1 2 3 4 5 -1.00 1.00 HS.415336 -0.01 0.82 -0.18 -0.57 -0.15 1 2 3 4 5 -1.00 1.00 DKFZP761O2018 -0.27 1.31 0.32 0.46 -0.47 1 2 3 4 5 -1.00 1.00 LOC285299 0.93 0.92 -0.08 0.94 -0.22 1 2 3 4 5 -1.00 1.00 HS.547465 -0.14 1.08 0.08 0.38 0.77 1 2 3 4 5 -1.00 1.00 OR2B3P -0.21 0.94 -0.06 0.11 0.09 1 2 3 4 5 -1.00 1.00 HS.544599 -0.27 0.34 -0.66 1.01 0.37 1 2 3 4 5 -1.00 1.00 HS.545188 -0.05 0.68 -0.32 1.18 -0.32 1 2 3 4 5 -1.00 1.00 HS.581032 0.18 0.40 -0.60 1.92 0.38 1 2 3 4 5 -1.00 1.00 HS.539278 0.03 1.08 0.08 -0.04 0.21 1 2 3 4 5 -1.00 1.00 IL4 -0.18 1.18 0.18 0.27 -0.03 1 2 3 4 5 -1.00 1.00 HS.538106 -0.67 1.15 0.15 0.22 0.53 1 2 3 4 5 -1.00 1.00 TCF1 0.57 0.43 -0.57 0.72 -0.58 1 2 3 4 5 -1.00 1.00 LOC493869 -0.15 0.86 -0.14 0.87 1.24 1 2 3 4 5 -1.00 1.00 HS.575725 0.70 1.36 0.36 0.22 -0.02 1 2 3 4 5 -1.00 1.00 HS.562928 1.31 0.77 -0.23 -0.21 -0.31 1 2 3 4 5 -1.00 1.00 HS.566134 -0.23 1.18 0.18 0.28 -0.08 1 2 3 4 5 -1.00 1.00 HS.560946 -0.05 0.82 -0.19 0.29 -0.16 1 2 3 4 5 -1.00 1.00 HS.434324 2.53 0.65 -0.35 1.14 -0.58 1 2 3 4 5 -1.00 1.00 GPR15 0.28 1.10 0.10 0.30 0.15 1 2 3 4 5 -1.00 1.00 ADRA2C -0.30; 0.32 -0.68 0.77 0.49 1 2 3 4 5 ; -1.00 1.00 HS.565546 -0.40 0.63 -0.37 0.16 1.39 1 2 3 4 5 -1.00 1.00 LOC646226 -1.07 0.07 -0.93 -0.51 1.63 1 2 3 4 5 -1.00 1.00 LOC285444 -0.08 0.85 -0.15 0.03 2.88 1 2 3 4 5 -1.00 1.00 HS.565969 1.10 1.05 0.05 1.08 0.57 1 2 3 4 5 -1.00 1.00 FAM71D 1.58 1.98 0.98 0.07 0.74 1 2 3 4 5 -1.00 1.00 LOC731444 0.07 0.84 -0.17 0.13 -0.11 1 2 3 4 5 -1.00 1.00 NAV2 -0.08 0.92 -0.09 -0.07 0.01 1 2 3 4 5 -1.00 1.00 LOC649406 0.71 -0.19 -1.20 1.83 -1.45 1 2 3 4 5 -1.00 1.00 GPM6B -0.46 1.60 0.59 0.37 0.29 1 2 3 4 5 -1.00 1.00 HS.334403 -0.60 0.05 -0.95 -1.13 -0.10 1 2 3 4 5 -1.00 1.00 HSD3B2 0.19 0.78 -0.22 0.05 -0.36 1 2 3 4 5 -1.00 1.00 HS.573767 -0.46 0.66 -0.34 0.21 -0.36 1 2 3 4 5 -1.00 1.00 HS.148762 0.04 1.02 0.01 -0.19 -0.21 1 2 3 4 5 -1.01 1.01 HS.356810 -0.34 0.64 -0.37 -0.12 -0.35 1 2 3 4 5 -1.01 1.01 GFPT2 -0.16 1.61 0.61 -0.25 0.26 1 2 3 4 5 -1.01 1.01 HS.135835 1.24 1.97 0.96 -0.14 0.74 1 2 3 4 5 -1.01 1.01 GNGT1 -0.26 0.48 -0.52 -0.28 0.46 1 2 3 4 5 -1.01 1.01 LOC646396 0.54 0.74 -0.27 -0.14 -0.10 1 2 3 4 5 -1.01 1.01 HS.134828 -0.10 0.92 -0.09 0.13 1.49 1 2 3 4 5 -1.01 1.01 HS.540716 -0.40 0.68 -0.33 -0.52 -0.31 1 2 3 4 5 -1.01 1.01 HS.540974 1.18 0.29 -0.72 -0.73 0.72 1 2 3 4 5 -1.01 1.01 LOC440368 -0.34 0.89 -0.12 -0.27 -0.39 1 2 3 4 5 -1.01 1.01 Table 3 107 HS.445581 -0.10 0.86 -0.14 -0.04 -0.02 1 2 3 4 5 -1.01 1.01 C110RF36 0.31 0.72 -0.28 -0.41 2.47 1 2 3 4 5 -1.01 1.01 HS.539083 0.08 1.15 0.14 -0.11 -0.06 1 2 3 4 5 -1.01 1.01 LOC730109 2.57 0.83 -0.18 0.02 0.13 1 2 3 4 5 -1.01 1.01 HS.516244 -0.38 0.68 -0.33 -0.90 -0.53 1 2 3 4 5 -1.01 1.01 LOC121006 1.45 0.91 -0.10 0.03 0.89 1 2 3 4 5 -1.01 1.01 HS.537951 1.49 1.51 0.50 2.84 3.26 1 2 3 4 5 -1.01 1.01 LOC646428 -0.42 0.15 -0.86 2.29 0.89 1 2 3 4 5 -1.01 1.01 LOC646835 1.29 2.11 1.09 -0.54 0.61 1 2 3 4 5 -1.01 1.01 THPO -0.70 0.94 -0.08 0.03 1.13 1 2 3 4 5 -1.01 1.01 LOC642439 1.07 1.07 0.06 -0.08 0.04 1 2 3 4 5 -1.01 1.01 HS.541345 1.65 0.58 -0.43 0.39 -0.58 1 2 3 4 5 -1.01 1.01 HS.543777 1.05 -0.18 -1.20 1.03 -1.16 1 2 3 4 5 -1.01 1.01 ZG16 -0.10 1.74 0.72 0.56 0.01 1 2 3 4 5 -1.01 1.01 HS.576777 -0.16 0.98 -0.04 -0.20 0.31 1 2 3 4 5 -1.01 1.01 LOC653564 -0.90 0.43 -0.59 0.89 -1.19 1 2 3 4 5 -1.01 1.01 HS.97954 1.46 1.21 0.20 0.20 -0.23 1 2 3 4 5 -1.01 1.01 HS.565144 -0.08 0.35 -0.66 -0.16 0.73 1 2 3 4 5 -1.01 1.01 HS.537553 -0.24 0.74 -0.27 0.20 -0.28 1 2 3 4 5 -1.01 1.01 HS.582064 1.34 0.93 -0.08 0.91 1.01 1 2 3 4 5 -1.02 1.02 HS.560763 1.32 1.77 0.75 1.24 3.90 1 2 3 4 5 -1.02 1.02 HS.546898 -0.11 0.91 -0.10 0.14 0.56 1 2 3 4 5 -1.02 1.02 HS.584305 1.94 0.95 -0.06 -0.21 0.60 1 2 3 4 5 -1.02 1.02 LOC645669 1.79 1.04 0.02 0.48 0.34 1 2 3 4 5 -1.02 1.02 HS.544799 0.12 0.34 -0.67 7.42 0.13 1 2 3 4 5 -1.02 1.02 HS.435133 5.27 0.80 -0.21 1.07 -0.05 1 2 3 4 5 -1.02 1.02 LOC647028 1.25 0.39 -0.62 -0.19 1.06 1 2 3 4 5 -1.02 1.02 LOC642037 -0.19 0.61 -0.40 -0.17 -0.13 1 2 3 4 5 -1.02 1.02 LOC286411 1.58 0.79 -0.22 -0.17 -0.19 1 2 3 4 5 -1.02 1.02 HS.566965 0.40 0.99 -0.03 -0.02 -0.33 1 2 3 4 5 -1.02 1.02 RARB 0.69 0.36 -0.65 -0.53 -0.23 1 2 3 4 5 -1.02 1.02 FU43950 0.00 1.04 0.02 0.05 -0.09 1 2 3 4 5 -1.02 1.02 HS.545275 0.46 1.09 0.07 -0.30 -0.34 1 2 3 4 5 -1.02 1.02 HS.23246 -0.85 0.66 -0.36 0.05 -0.69 1 2 3 4 5 -1.02 1.02 HS.541454 1.35 0.24 -0.78 4.28 0.15 1 2 3 4 5 -1.02 1.02 CEACAM16 1.85 0.82 -0.20 1.56 -0.20 1 2 3 4 5 -1.02 1.02 LOC643325 -0.19 1.06 0.04 0.16 0.21 1 2 3 4 5 -1.02 1.02 NPY1R 3.77 0.57 -0.46 -0.21 -0.07 1 2 3 4 5 -1.02 1.02 HS.581530 2.16 0.64 -0.38 -0.55 0.53 1 2 3 4 5 -1.02 1.02 FSD2 0.15 0.51 -0.52 -0.23 0.36 1 2 3 4 5 -1.02 1.02 SNAI2 0.50 0.56 -0.46 0.51 -0.22 1 2 3 4 5 -1.02 1.02 HS.541633 0.46 1.71 0.68 0.21 0.46 1 2 3 4 5 -1.02 1.02 EYA2 0.06 1.32 0.30 0.18 0.42 1 2 3 4 5 -1.02 1.02 HS.297320 -0.24 1.13 0.11 0.06 -0.29 1 2 3 4 5 -1.02 1.02 HS.564352 -0.33 0.74 -0.29 1.39 -0.02 1 2 3 4 5 -1.02 1.02 SLC5A9 0.26 0.83 -0.19 0.18 0.12 1 2 3 4 5 -1.02 1.02 HS.566209 0.65 -0.04 -1.06 -0.14 -0.04 1 2 3 4 5 -1.02 1.02 HS.545838 0.58 1.12 0.10 0.91 0.07 1 2 3 4 5 -1.02 1.02 ALX4 -0.85 0.34 -0.68 -0.74 0.53 1 2 3 4 5 -1.02 1.02 Table 3 108

HS.444615 0.48 0.52 -0.51 -0.23 -0.41 1 2 3 4 5 -1.02 1.02 LOC651055 -0.31 0.73 -0.29 0.67 -0.09 1 2 3 4 5 -1.02 1.02 HS.158720 -0.10 0.42 -0.61 -1.09 -0.70 1 2 3 4 5 -1.02 1.02 HS.554074 0.09 0.38 -0.64 0.82 0.06 1 2 3 4 5 -1.02 1.02 LOC652781 -0.66 0.57 -0.46 -0.30 -0.65 1 2 3 4 5 -1.02 1.02 FRMD5 -0.38 0.82 -0.21 1.53 2.31 1 2 3 4 5 -1.02 1.02 LOC283682 0.95 0.35 -0.67 -0.20 1.92 1 2 3 4 5 -1.03 1.03 GLT6D1 -0.11 0.58 -0.45 -0.41 -0.39 1 2 3 4 5 -1.03 1.03 MGC4294 1.59 1.90 0.88 -0.55 -0.22 1 2 3 4 5 -1.03 1.03 CST8 -0.92 0.81 -0.21 -0.83 0.17 1 2 3 4 5 -1.03 1.03 RBMY1E -0.15 0.74 -0.29 0.13 -0.51 1 2 3 4 5 -1.03 1.03 HS.524163 -0.11 0.66 -0.37 1.52 -0.07 1 2 3 4 5 -1.03 1.03 LOC401087 -1.10 0.87 -0.15 -0.43 -0.73 1 2 3 4 5 -1.03 1.03 HS.565676 0.28 1.19 0.17 0.80 0.60 1 2 3 4 5 -1.03 1.03 LOC127150 -0.08 0.87 -0.16 -0.23 1.11 1 2 3 4 5 -1.03 1.03 GABRA3 -0.75 -0.13 -1.15 -0.73 -0.75 1 2 3 4 5 -1.03 1.03 HS.146343 0.46 1.32 0.30 -0.04 0.23 1 2 3 4 5 -1.03 1.03 HS.567029 0.20 1.19 0.17 0.06 -0.34 1 2 3 4 5 -1.03 1.03 HS.134845 0.53 0.72 -0.31 -0.16 0.50 1 2 3 4 5 -1.03 1.03 HS.87586 0.06 0.74 -0.29 -0.89 -0.30 1 2 3 4 5 -1.03 1.03 HS.551077 0.54 0.90 -0.13 -0.08 0.08 1 2 3 4 5 -1.03 1.03 LOC645291 -0.67 0.32 -0.71 -0.38 -0.11 1 2 3 4 5 -1.03 1.03 HS.486398 0.59 2.06 1.03 -0.15 0.13 1 2 3 4 5 -1.03 1.03 HS.372306 0.19 0.41 -0.62 -0.28 -0.19 1 2 3 4 5 -1.03 1.03 TTTY3 0.88 0.87 -0.16 -0.62 2.80 1 2 3 4 5 -1.03 1.03 LGR4 -0.73 0.21 -0.82 2.76 -0.41 1 2 3 4 -1.03 1.03 KRTAP5-7 -0.49 0.57 -0.46 -0.10 -0.69 1 2 3 4 5 -1.03 1.03 LOC648432 0.87 1.76 0.73 0.46 -0.04 1 2 3 4 5 -1.03 1.03 HS.574758 1.32 0.59 -0.44 0.09 0.05 1 2 3 4 5 -1.03 1.03 LOC646781 1.91 1.78 0.75 2.65 0.07 1 2 3 4 5 -1.03 1.03 ECAT1 -0.67 0.77 -0.26 -0.46 1.79 1 2 3 4 5 -1.03 1.03 HS.581865 0.02 0.53 -0.50 -0.20 1.38 1 2 3 4 5 -1.03 1.03 HS.544715 0.40 1.08 0.05 0.02 0.52 1 2 3 4 5 -1.03 1.03 HS.538606 -0.64 0.23 -0.81 1.95 -0.48 1 2 3 4 5 -1.03 1.03 LOC645402 1.47 1.27 0.24 0.33 -0.03 1 2 3 4 5 -1.03 1.03 LOC645043 -0.67 0.62 -0.42 0.39 -0.25 1 2 3 4 5 -1.03 1.03 LOC643045 0.27 0.87 -0.16 -0.18 -0.04 1 2 3 4 5 -1.03 1.03 C20ORF95 -0.22 1.08 0.05 0.07 0.01 1 2 3 4 5 -1.03 1.03 LOC643529 0.41 0.80 -0.23 0.65 -0.02 1 2 3 4 5 -1.03 1.03 OR51I2 0.11 0.63 -0.40 -0.46 0.35 1 2 3 4 5 -1.03 1.03 LOC729900 -0.56 0.13 -0.90 -0.10 -0.37 1 2 3 4 5 -1.03 1.03 HS.561041 -0.55 0.51 -0.53· ' -0.45 0.34 1 2 3 4 5 -1.03 1.03 LOC642121 1.19 1.45 0.41 2.77 0.09 1 2 3 4 5 -1.03 1.03 FAM26D -0.28 0.39 -0.65 -0.42 -0.57 1 2 3 4 5 -1.03 1.03 HS.171267 0.21 0.81 -0.23 -0.73 0.06 1 2 3 4 5 -1.03 1.03 LOC641994 0.50 1.39 0.35 0.86 0.21 1 2 3 4 5 -1.04 1.04 HS.545121 -0.28 0.97 -0.06 -0.12 0.19 1 2 3 4 5 -1.04 1.04 HS.569276 0.37 0.86 -0.18 -0.19 -0.95 1 2 3 4 5 -1.04 1.04 LHFPL4 -0.23 0.75 -0.28 -0.12 0.57 1 2 3 4 5 -1.04 1.04 Table 3 109 DRD5 -0.99 1.62 0.58 0.20 -0.16 1 2 3 4 5 -1.04 1.04 HS.542952 -0.20 0.72 -0.32 0.68 0.04 1 2 3 4 5 -1.04 1.04 LOC650771 0.73 1.02 -0.01 -0.38 -0.95 1 2 3 4 5 -1.04 1.04 C50RF42 -0.06 0.98 -0.06 -0.14 -0.01 1 2 3 4 5 -1.04 1.04 XKR3 -0.87 0.30 -0.73 -0.41 2.69 1 2 3 4 5 -1.04 1.04 LOC646383 0.98 1.19 0.15 0.02 0.67 1 2 3 4 5 -1.04 1.04 LOC440297 0.28 0.74 -0.29 3.06 1.67 1 2 3 4 5 -1.04 1.04 PCDHA12 1.50: 2.02 0.98 -0.31 0.40 1 2 3 4 5 -1.04 1.04 LOC642744 0.53 0.41 -0.63 0.33 0.12 1 2 3 4 5 -1.04 1.04 INHBC 0.74 0.68 -0.36 -0.61 -0.56 1 2 3 4 5 -1.04 1.04 SEMA7A 0.06 0.92 -0.12 -0.03 0.49 1 2 3 4 5 -1.04 1.04 HS.552276 -0.35 0.81 -0.23 -0.34 -0.03 1 2 3 4 5 -1.04 1.04 SLC4A10 -1.55 0.53 -0.51 0.36 -0.74 1 2 3 4 5 -1.04 1.04 LDB3 -0.72 1.24 0.20 -0.23 0.07 1 2 3 4 5 -1.04 1.04 C30RF41 -0.57 0.41 -0.63 0.39 0.16 1 2 3 4 5 -1.04 1.04 LOC651610 0.17 0.66 -0.37 0.38 1.89 1 2 3 4 5 -1.04 1.04 LOC646098 -1.03 0.40 -0.64 -1.22 -0.29 1 2 3 4 5 -1.04 1.04 HS.577961 -0.11 0.21 -0.83 -0.62 0.61 1 2 3 4 5 -1.04 1.04 LOC730713 -0.01 0.73 -0.31 1.79 -0.38 1 2 3 4 5 -1.04 1.04 SPRR2G -0.13 0.56 -0.48 -0.35 -0.55 1 2 3 4 5 -1.04 1.04 SLIT1 0.13 0.89 -0.15 -0.03 -0.31 1 2 3 4 5 -1.04 1.04 HS.562311 1.33 0.33 -0.71 -0.11 1.76 1 2 3 4 5 -1.04 1.04 LOC645799 -0.34 0.05 -0.99 -0.60 -0.37 1 2 3 4 5 -1.04 1.04 SV2C 0.25 1.25 0.21 -0.14 0.13 1 2 3 4 5 -1.04 1.04 HS.562301 -0.91 0.54 -0.50 -0.78 0.89 1 2 3 4 5 -1.04 1.04 RXRG 1.35 0.52 -0.53 -0.63 -0.48 1 2 3 4 5 -1.04 1.04 HS.553108 1.41 1.20 0.15 0.18 0.24 1 2 3 4 5 -1.04 1.04 HS.563833 2.43 0.60 -0.45 2.08 -0.42 1 2 3 4 5 -1.04 1.04 HS.232769 0.03 0.67 -0.37 0.61 0.16 1 2 3 4 5 -1.04 1.04 HS.124358 0.19 1.28 0.24 2.13 -0.17 1 2 3 4 5 -1.04 1.04 0R6Y1 0.27 0.72 -0.32 -0.48 0.31 1 2 3 4 5 -1.04 1.04 HS.542096 -0.35 1.08 0.03 -0.24 1.49 1 2 3 4 5 -1.04 1.04 THSD1 -0.81 0.26 -0.79 0.44 -0.35 1 2 3 4 5 -1.05 1.05 KRTAP13-3 1.31 1.01 -0.04 0.02 0.30 1 2 3 4 5 -1.05 1.05 RAP1GAP 0.06 0.42 -0.63 -0.22 -0.07 1 2 3 4 5 -1.05 1.05 LOC728369 -0.17 1.62 0.57 0.57 0.41 1 2 3 4 5 -1.05 1.05 LOC652828 -0.57 1.37 0.32 0.31 2.25 1 2 3 4 5 -1.05 1.05 HS.543736 0.44 1.08 0.04 0.77 0.26 1 2 3 4 5 -1.05 1.05 HSFY2 0.38 -0.07 -1.12 0.65 -0.60 1 2 3 4 5 -1.05 1.05 LOC341346 0.09 0.58 -0.47 -0.31 -0.33 1 2 3 4 5 -1.05 1.05 HS.134656 0.00 0.86 -0.19 0.14 -0.58 1 2 3 4 5 -1.05 1.05 ITGA11 0.14 1.00 -0.05 -0.06 0.21 1 2 3 4 5 -1.05 1.05 HS.543635 0.19 0.81 -0.24 -0.29 0.15 1 2 3 4 5 -1.05 1.05 HS.518354 -0.06 1.16 0.11 0.03 0.39 1 2 3 4 5 -1.05 1.05 HS.570775 -0.23 0.82 -0.22 0.05 0.66 1 2 3 4 5 -1.05 1.05 HS.224418 1.11 0.80 -0.25 -0.05 0.27 1 2 3 4 5 -1.05 1.05 ATXN3L 0.99 0.36 -0.69 -0.27 4.21 1 2 3 4 5 -1.05 1.05 LOC131149 0.44 1.28 0.23 -0.24 0.89 1 2 3 4 5 -1.05 1.05 CNTN3 0.43 1.09 0.04 1.52 -0.16 1 2 3 4 5 -1.05 1.05 Table 3 110 HS.542646 -0.37 0.78 -0.27 0.17 -0.17 1 2 3 4 5 -1.05 1.05 HS.575589 -0.42 0.20 -0.85 2.49 0.46 1 2 3 4 5 -1.05 1.05 TSSK4 -0.38 0.91 -0.14 -0.06 0.10 1 2 3 4 5 -1.05 1.05 LOC642861 -0.07 -0.04 -1.09 2.99 -0.43 1 2 3 4 5 -1.05 1.05 HS.545658 -0.47 0.75 -0.30 1.39 2.25 1 2 3 4 5 -1.05 1.05 HS.537973 0.74 1.24 0.18 -0.07 1.50 1 2 3 4 5 ; -1.05 1.05 LOC730049 -0.44 1.52 0.47 0.48 2.74 1 2 3 4 5 -1.05 1.05 HS.534529 0.36 0.65 -0.40 -0.13 -0.14 1 2 3 4 5 -1.05 1.05 HS.566126 0.82 0.75 -0.30 -0.37 -0.21 1 2 3 4 5 -1.05 1.05 HS.571432 -0.19 -0.20 -1.25 1.17 0.36 1 2 3 4 5 -1.05 1.05 ATF7 1.57 0.82 -0.23 2.62 0.00 1 2 3 4 5 -1.05 1.05 HS.484705 0.26 1.82 0.77 2.07 -0.05 1 2 3 4 5 -1.05 1.05 LOC389300 1.34 1.72 0.66 2.04 -0.63 1 2 3 4 5 -1.05 1.05 C20RF27 -0.27 1.79 0.73 0.18 0.64 1 2 3 4 5 -1.05 1.05 LOC400163 -0.74 -0.14 -1.20 3.04 -0.39 1 2 3 4 5 -1.05 1.05 LOC221091 1.72 1.18 0.13 -0.08 0.70 1 2 3 4 5 -1.05 1.05 HS.209249 0.09 1.08 0.03 0.22 2.09 1 2 3 4 5 -1.05 1.05 HS.560143 2.21 0.67 -0.38 -0.41 -0.03 1 2 3 4 5 -1.05 1.05 LOC645869 0.76 0.74 -0.31 -0.63 -0.53 1 2 3 4 5 -1.05 1.05 LOC653493 -0.39 0.40 -0.65 -0.37 -0.60 1 2 3 4 5 -1.05 1.05 LOC645200 1.31 -0.06 -1.11 -0.44 0.74 1 2 3 4 5 -1.05 1.05 NR5A2 -0.35 2.80 1.74 1.96 0.20 1 2 3 4 5 -1.05 1.05 HS.534338 0.37 1.67 0.62 0.24 0.03 1 2 3 4 5 -1.06 1.06 HIGD1B 4.50 0.34 -0.72 -0.40 1.12 1 2 3 4 -1.06 1.06 HS.371906 -0.37 0.99 -0.07 -0.15 0.01 1 2 3 4 5 -1.06 1.06 T EM 61 -0.34 0.69 -0.37 -0.30 -0.03 1 2 3 4 5 -1.06 1.06 LOC390507 0.40 1.27 0.21 1.94 0.03 1 2 3 4 5 -1.06 1.06 LOC642852 -0.06 0.96 -0.10 0.00 -0.11 1 2 3 4 5 -1.06 1.06 SLC25A41 2.39 0.49 -0.57 1.45 -0.78 1 2 3 4 5 -1.06 1.06 LOC92154 -0.36 1.25 0.19 -0.92 1.90 1 2 3 4 5 -1.06 1.06 DEFB105A -0.37 0.42 -0.64 0.04 1.50 1 2 3 4 5 -1.06 1.06 0R1G1 1.01 1.06 0.01 1.21 -0.73 1 2 3 4 5 -1.06 1.06 LOC340598 0.54 1.32 0.26 -0.05 -0.27 1 2 3 4 5 -1.06 1.06 HS.332132 0.76 0.99 -0.06 -0.15 0.30 1 2 3 4 5 -1.06 1.06 OVOL1 1.82 2.13 1.07 3.10 -0.57 1 2 3 4 5 -1.06 1.06 HS.570364 0.17 2.00 0.94 0.51 1.55 1 2 3 4 5 -1.06 1.06 FGF21 1.17 0.82 -0.24 0.50 -0.19 1 2 3 4 5 -1.06 1.06 HS.170960 0.49 0.28 -0.78 -0.06 -0.63 1 2 3 4 5 -1.06 1.06 LOC652142 -0.34; 1.77 0.71 -0.67 0.10 1 2 3 4 5 -1.06 1.06 HIST1H2BB -0.60 3.13 2.07 0.66 0.08 1 2 3 4 5 -1.06 1.06 LOC642849 3.62 1.01 -0.05 1.09 0.46 1 2 3 4 5 -1.06 1.06 HS.561852 1.26 0.56 -0.49 0.25 -0.49 · 1 2 3 4 5 -1.06 1.06 ANKRD45 -0.22 1.35 0.29 0.07 -0.36 1 2 3 4 5 -1.06 1.06 HS.566966 -0.12 0.36 -0.70 -0.54 0.82 1 2 3 4 5 -1.06 1.06 HS.244018 0.56 -0.11 -1.17 -0.39 -0.31 1 2 3 4 5 -1.06 1.06 HS.574219 -0.90 1.35 0.28 0.59 1.34 1 2 3 4 5 -1.06 1.06 SPAM1 0.15 1.41 0.35 -0.57 -0.44 1 2 3 4 5 -1.06 1.06 DND1 -0.18 0.68 -0.38 0.11 0.42 1 2 3 4 5 -1.06 1.06 CSN2 0.44 1.64 0.58 -0.29 0.69 1 2 3 4 5 -1.06 1.06 Table 3 111 LOC497190 -0.05 1.16 0.10 0.07 0.03 1 2 3 4 5 -1.06 1.06 HS.528796 0.54 1.10 0.03 -0.20 -0.27 1 2 3 4 5 -1.06 1.06 LOC646667 -0.26 1.39 0.33 -0.19 -0.43 1 2 3 4 5 -1.06 1.06 HS.531728 1.24 0.99 -0.08 0.47 -0.11 1 2 3 4 5 -1.06 1.06 LOC729335 -0.15 1.03 -0.03 0.12 0.23 1 2 3 4 5 -1.06 1.06 HS.232175 -0.27 0.07 -0.99 0.41 0.04 1 2 3 4 5 -1.06 1.06 LOC648481 0.08 0.50 -0.57 1.77 0.50 1 2 3 4 5 -1.06 1.06 AADACL3 0.49 0.44 -0.62 0.90 1.78 1 2 3 4 5 -1.06 1.06 DCDC2B 2.07 -0.19 -1.25 -1.11 -0.77 1 2 3 4 5 -1.06 1.06 HS.542267 -0.14 0.95 -0.11 -0.22 1.49 1 2 3 4 5 -1.06 1.06 HS.565022 -0.63 0.69 -0.38 0.91 -0.39 1 2 3 4 5 -1.06 1.06 RNF190 2.64 0.94 -0.12 1.83 -0.22 1 2 3 4 5 -1.06 1.06 HS.539567 -0.20 1.06 0.00 -0.10 0.73 1 2 3 4 5 -1.06 1.06 HS.516300 -0.48 1.32 0.25 0.35 0.32 1 2 3 4 5 -1.07 1.07 HS.542512 5.40 1.04 -0.02 1.26 -0.05 1 2 3 4 5 -1.07 1.07 HS.518665 0.97 0.93 -0.13 2.03 0.20 1 2 3 4 5 -1.07 1.07 LOC389958 -0.43 1.09 0.03 0.72 -0.40 1 2 3 4 5 -1.07 1.07 INSRR 0.38 0.31 -0.76 0.18 -0.48 1 2 3 4 5 -1.07 1.07 HS.525681 -0.61 0.65 -0.42 -0.13 0.00 1 2 3 4 5 -1.07 1.07 LOC642119 -0.62 1.80 0.73 -0.15 0.11 1 2 3 4 5 -1.07 1.07 HS.569540 -0.35 0.66 -0.40 1.50 2.05 1 2 3 4 5 -1.07 1.07 LOC643262 -0.20 0.58 -0.49 -0.37 -0.22 1 2 3 4 5 -1.07 1.07 LOC652618 1.29 0.41 -0.65 -1.12 -1.13 1 2 3 4 5 -1.07 1.07 IGF1R 0.11 0.98 -0.09 0.29 -0.06 1 2 3 4 5 -1.07 1.07 HS.368071 -0.09 1.10 0.03 -0.18 -0.19 1 2 3 4 5 ; -1.07 1.07 HS.542024 1.71 0.84 -0.23 0.06 0.53 1 2 3 4 5 -1.07 1.07 KCNC4 -0.36 0.16 -0.91 -1.06 -1.47 1 2 3 4 5 -1.07 1.07 HS.436972 2.91 1.21 0.14 0.05 -0.04 1 2 3 4 5 -1.07 1.07 FAM153C -0.01 0.33 -0.74 -0.62 -0.13 1 2 3 4 5 -1.07 1.07 ZNF354C 0.55 0.41 -0.66 1.23 1.49 1 2 3 4 5 -1.07 1.07 HS.578776 -0.60 0.82 -0.25 -0.41 -0.23 1 2 3 4 5 -1.07 1.07 HS.145909 0.16 1.00 -0.07 1.14 0.09 1 2 3 4 5 -1.07 1.07 HS.132254 0.23 0.32 -0.75 0.29 -0.47 1 2 3 4 5 -1.07 1.07 HS.120364 1.18 1.23 0.16 -0.15 -0.16 1 2 3 4 5 -1.07 1.07 NXF2 -0.63 0.70 -0.38 0.32 -0.98 1 2 3 4 5 -1.07 1.07 HS.212492 -1.19 -0.12 -1.19 3.33 -0.26 1 2 3 4 5 -1.07 1.07 ADAM3A 3.57 1.18 0.10 4.53 -0.94 1 2 3 4 5 -1.07 1.07 0R8G1 -0.47 0.38 -0.69 -0.20 1.02 1 2 3 4 5 -1.07 1.07 HSPB2 -0.20 1.46 0.39 -0.05 0.06 1 2 3 4 5 -1.07 1.07 LOC389830 1.01 0.90 -0.17 0.22 -0.32 1 2 3 4 5 -1.07 1.07 LOC646227 -0.22 0.91 -0.17 0.27 0.05 1 2 3 4 5 -1.07 1.07 HS.566241 0.10 1.07 0.00 -0.07 0.28 1 2 3 4 5 -1.07 1.07 LOC652802 -0.70 1.49 0.42 0.67 -0.36 1 2 3 4 5 -1.07 1.07 POLA 0.13 1.11 0.04 0.11 0.63 1 2 3 4 5 -1.07 1.07 HS.124672 5.23 2.07 1.00 1.64 -0.08 1 2 3 4 5 -1.07 1.07 ARHGAP23 2.04 0.90 -0.17 -0.03 0.27 1 2 3 4 5 -1.07 1.07 REM1 2.69 0.81 -0.26 1.83 -0.11 1 2 3 4 5 -1.07 1.07 HS.540607 0.07 1.03 -0.04 0.25 0.00 1 2 3 4 5 -1.07 1.07 KIRREL2 -0.70 1.27 0.19 -0.19 -0.57 1 2 3 4 5 -1.07 1.07 Table 3 112 LOC645066 -0.61 0.51 -0.57 1.64 0.11 1 2 3 4 5 -1.07 1.07 INHBA 0.30 0.14 -0.93 0.43 -0.32 1 2 3 4 5 -1.07 1.07 BLOC1S2 0.34 0.96 -0.11 -0.07 -0.09 1 2 3 4 5 -1.07 1.07 SLIT3 -0.24 0.88 -0.20 1.92 3.65 1 2 3 4 5 -1.07 1.07 HOXA3 1.28 0.25 -0.83 -0.12 0.17 1 2 3 4 5 -1.08 1.08 LOC643237 1.71 0.84 -0.24 -0.10 0.94 1 2 3 4 5 -1.08 1.08 PCDHA2 -1.03 0.88 -0.20 1.48 -0.70 1 2 3 4 5 -1.08 1.08 HS.133889 -0.19 0.77 -0.31 -0.25 0.11 1 2 3 4 5 -1.08 1.08 HS.562886 0.33 1.22 0.14 -0.26 1.46 1 2 3 4 5 -1.08 1.08 HS.560591 -0.23 1.03 -0.05 -0.31 0.78 1 2 3 4 5 -1.08 1.08 LOC646515 -0.22 1.13 0.05 -0.03 0.36 1 2 3 4 5 -1.08 1.08 MYH14 0.69 0.59 -0.49 -0.29 -0.49 1 2 3 4 5 -1.08 1.08 LOC441127 0.97 0.35 -0.73 0.11 0.32 1 2 3 4 5 -1.08 1.08 SEC14L3 -0.81 0.70 -0.38 0.59 -0.80 1 2 3 4 5 -1.08 1.08 HS.538118 -0.39 -0.29 -1.36 1.44 0.12 1 2 3 4 5 -1.08 1.08 HS.87124 -0.24 0.60 -0.48 0.72 0.86 1 2 3 4 5 -1.08 1.08 HS.130414 1.13 0.45 -0.63 1.85 2.06 1 2 3 4 5 -1.08 1.08 C170RF57 0.14 0.77 -0.31 0.06 0.55 1 2 3 4 5 -1.08 1.08 HS.148294 0.06 0.29 -0.79 0.13 -0.64 1 2 3 4 5 -1.08 1.08 HS.564051 0.22 1.49 0.41 0.69 -0.48 1 2 3 4 5 -1.08 1.08 LOC653645 -0.77 0.56 -0.52 1.87 -0.13 1 2 3 4 5 -1.08 1.08 HS.177532 0.04 1.08 0.00 0.70 0.27 1 2 3 4 5 -1.08 1.08 HS.544892 2.71 0.61 -0.47 0.10 -0.56 1 2 3 4 5 -1.08 1.08 HS.541556 1.24 0.45 -0.63 1.75 0.62 1 2 3 4 5 -1.08 1.08 HS.97507 -0.02 0.82 -0.27 0.84 0.19 1 2 3 4 5 -1.08 1.08 MT1JP 0.221 0.91 -0.18 0.79 -0.05 1 2 3 4 5 -1.08 1.08 HS.570167 0.27 0.54 -0.54 -0.14 0.55 1 2 3 4 5 -1.08 1.08 HS.546217 -0.32 0.36 -0.72 1.44 0.05 1 2 3 4 5 -1.08 1.08 LOC650087 0.00 1.09 0.01 0.00 0.01 1 2 3 4 5 -1.08 1.08 HS.383206 5.78 0.22 -0.86 -0.06 0.26 1 2 3 4 5 -1.08 1.08 LOC647286 0.18 0.45 -0.64 1.87 -0.27 1 2 3 4 5 -1.08 1.08 TRIM55 -1.08 ' 1.27 0.18 -1.31 1.10 1 2 3 4 5 -1.08 1.08 HS.580965 -0.17 1.06 -0.02 -0.03 -0.15 1 2 3 4 5 -1.08 1.08 HS.563400 0.88 0.37 -0.72 -0.65 0.76 1 2 3 4 5 -1.08 1.08 HS.570945 -0.40 1.70 0.61 -0.84 1.02 1 2 3 4 5 -1.08 1.08 HS.550794 -0.78 0.72 -0.37 -0.40 -0.49 1 2 3 4 5 -1.08 1.08 HS.193876 0.39 0.79 -0.29 -0.15 -0.11 1 2 3 4 5 -1.08 1.08 HS.544610 2.03 0.58 -0.50 0.36 2.73 1 2 3 4 5 -1.08 1.08 NTN2L -0.34 0.69 -0.39 -1.06 -0.55 1 2 3 4 5 -1.08 1.08 TREML4 -0.31 1.60 0.52 0.84 -0.02 1 2 3 4 5 -1.08 1.08 ZCCHC16 0.83 0.52 -0.57 0.23 -0.05 1 2 3 4 5 -1.09 1.09 LOC642659 -0.27 0.74 -0.35 -0.21 -0.12 1 2 3 4 5 -1.09 1.09 HS.199896 2.87 1.04 -0.04 -0.25 0.21 1 2 3 4 5 -1.09 1.09 HS.566024 -0.15 0.89 -0.20 -0.24 -0.08 1 2 3 4 5 -1.09 1.09 LOC647534 -0.56 0.74 -0.35 0.09 0.83 1 2 3 4 5 -1.09 1.09 HS.568676 -0.04 1.04 -0.05 -0.01 -0.01 1 2 3 4 5 -1.09 1.09 PCBP3 -0.30 0.62 -0.47 0.20 -0.34 1 2 3 4 5 -1.09 1.09 LOC653787 -0.27 0.93 -0.16 0.14 0.32 1 2 3 4 5 -1.09 1.09 HS.564701 -0.16 0.90 -0.19 -0.05 0.57 1 2 3 4 5 -1.09 1.09 Table 3 113 LOC388931 0.16 0.84 -0.24 0.22 -0.01 1 2 3 4 5 -1.09 1.09 HS.567207 0.35 0.28 -0.81 1.93 -0.64 1 2 3 4 5 -1.09 1.09 LOC651746 -0.16 0.80 -0.29 -0.65 -0.30 1 2 3 4 5 -1.09 1.09 LOC645852 2.18 0.83 -0.26 -0.62 -0.23 1 2 3 4 5 -1.09 1.09 HS.550101 0.45 1.06 -0.03 0.27 -0.32 1 2 3 4 5 -1.09 1.09 TCF2 0.29 -0.17 -1.26 -1.21 0.91 1 2 3 4 5 -1.09 1.09 LOC644294 4.40 2.22 1.13 1.35 -1.51 1 2 3 4 5 -1.09 1.09 HS.561205 -0.09 1.13 0.04 0.42 -0.02 1 2 3 4 5 -1.09 1.09 HS.268250 1.95 2.26 1.17 -0.46 4.37 1 2 3 4 5 -1.09 1.09 LOC644856 -0.29 1.25 0.16 0.67 0.27 1 2 3 4 5 -1.09 1.09 HS.62007 -0.43 0.76 -0.34 0.50 0.30 1 2 3 4 5 -1.09 1.09 LOC648117 0.10 -0.05 -1.14 -0.44 -0.10 1 2 3 4 5 -1.09 1.09 HS.540466 2.25 2.14 1.05 -0.33 -0.54 1 2 3 4 5 -1.09 1.09 LOC642685 1.49 0.93 -0.16 0.61 0.57 1 2 3 4 5 -1.09 1.09 LOC400708 -0.10 0.99 -0.10 0.03 0.03 1 2 3 4 5 -1.09 1.09 HS.580542 2.73 0.52 -0.57 -0.13 -0.77 1 2 3 4 5 -1.09 1.09 HS.444974 -0.29 1.06 -0.03 -0.13 -0.13 1 2 3 4 5 -1.09 1.09 LOC651848 0.84 0.75 -0.34 -0.07 0.80 1 2 3 4 5 -1.09 1.09 HS.577227 -0.10 0.98 -0.12 0.25 0.03 1 2 3 4 5 -1.09 1.09 HS.445683 0.46 0.89 -0.21 -0.08 -0.17 1 2 3 4 5 -1.09 1.09 HSPB9 0.81 0.00 -1.09 0.15 2.57 1 2 3 4 5 -1.09 1.09 LOC645273 -0.31 0.58 -0.51 0.14 -0.36 1 2 3 4 5 -1.09 1.09 HS.575551 1.54 0.86 -0.23 0.51 1.43 1 2 3 4 5 -1.09 1.09 AQP2 -0.54 0.74 -0.36 -0.24 -0.06 1 2 3 4 5 -1.10 1.10 HS.554692 -1.12 0.58 -0.52 0.36 -0.01 1 2 3 4 5 -1.10 1.10 HS.538290 -0.22 1.85 0.76 -0.54 0.59 1 2 3 4 5 -1.10 1.10 MATN2 1.02 0.78 -0.32 -0.47 0.13 1 2 3 4 5 -1.10 1.10 HS.543218 0.19; 1.26 0.17 -0.06 1.34 1 2 3 4 5 -1.10 1.10 LOC440356 1.70 1.21 0.11 0.18 0.25 1 2 3 4 5 -1.10 1.10 IL22 0.29 0.45 -0.65 0.02 1.34 1 2 3 4 5 -1.10 1.10 HS.49127 1.39 0.72 -0.38 2.80 1.98 1 2 3 4 5 -1.10 1.10 IGFL1 0.31 0.32 -0.77 -0.29 1.11 1 2 3 4 5 -1.10 1.10 HS.563388 -0.34 1.31 0.21 0.84 0.20 1 2 3 4 5 -i.io 1.10 HS.42419 -0.19 0.94 -0.16 -0.10 0.35 1 2 3 4 5 -1.10 1.10 LOC645724 1.82 0.77 -0.33 -0.09 0.22 1 2 3 4 5 -1.10 1.10 HS.385813 -0.25 1.08 -0.02 -0.22 1.31 1 2 3 4 5 -1.10 1.10 HS.566299 0.32 0.90 -0.20 0.32 0.90 1 2 3 4 5 -1.10 1.10 HS.562524 -0.57 1.68 0.58 1.13 0.65 1 2 3 4 5 -1.10 1.10 HS.565475 -0.33 1.04 -0.06 0.00 -0.03 1 2 3 4 5 -1.10 1.10 PPP1R2P3 1.86 0.07 -1.03 -0.18 0.03 1 2 3 4 5 -1.10 1.10 HS.128263 0.49 0.12 -0.98 0.50 -1.01 1 2 3 4 5 -1.10 1.10 HS.571013 -0.05 1.01 -0.09 0.00 0.94 1 2 3 4 5 -1.10 1.10 HS.146933 0.09 0.75 -0.35 0.60 0.37 1 2 3 4 5 -1.10 1.10 C4B 1.32 0.06 -1.04 -1.12 -0.60 1 2 3 4 5 -1.10 1.10 R0B01 -0.36 0.74 -0.37 0.17 -0.32 1 2 3 4 5 -1.10 1.10 HS.541901 -0.23 0.98 -0.12 -0.15 -0.04 1 2 3 4 5 -1.10 1.10 HS.583359 -0.41 2.13 1.03 -0.24 -0.21 1 2 3 4 5 -1.10 1.10 LOC392781 2.24 0.52 -0.58 0.43 1.68 1 2 3 4 5 -1.10 1.10 HEPACAM 0.12 0.77 -0.33 -0.35 -0.20 1 2 3 4 5 -1.10 1.10 Table 3 114 HS.574065 0.23 0.54 -0.57 0.06 -0.27 1 2 3 4 5 -1.10 1.10 LOC253012 -0.28 0.44 -0.66 1.12 0.20 1 2 3 4 5 -1.10 1.10 HS.540422 -0.77 0.73 -0.37 0.07 1.55 1 2 3 4 5 -1.11 1.11 RNF133 0.28 0.91 -0.19 0.16 1.43 1 2 3 4 5 -1.11 1.11 HS.112791 -0.41 0.25 -0.85 -0.11 -0.65 1 2 3 4 5 -1.11 1.11 LOC388476 -0.23 0.76 -0.34 0.79 0.44 1 2 3 4 5 -1.11 1.11 HS.297557 0.16 1.90 0.79 3.08 -0.16 1 2 3 4 5 -1.11 1.11 LOC652476 0.56 0.45 -0.66 0.15 1.14 1 2 3 4 5 -1.11 1.11 ROS1 0.99 -0.03 -1.14 2.29 0.31 1 2 3 4 5 -1.11 1.11 HS.540973 -0.55 0.73 -0.38 -0.26 0.58 1 2 3 4 5 -1.11 1.11 C40RF31 0.76 1.74 0.64 4.48 -0.49 1 2 3 4 5 -1.11 1.11 HS.564084 -0.33 0.71 -0.40 0.19 4.41 1 2 3 4 5 -1.11 1.11 HS.565370 0.08 0.67 -0.43 1.11 -0.51 1 2 3 4 5 -1.11 1.11 HS.561746 -0.07 0.27 -0.84 -0.46 -0.16 1 2 3 4 5 -1.11 1.11 LOC646071 0.85 0.84 -0.27 0.40 0.08 1 2 3 4 5 -1.11 1.11 PIH1D2 3.29 1.14 0.03 -1.83 1.88 1 2 3 4 5 -1.11 1.11 ZNF117 0.31 0.38 -0.73 0.18 0.08 1 2 3 4 5 -1.11 1.11 HS.543930 -0.07 0.77 -0.34 0.27 -0.43 1 2 3 4 5 -1.11 1.11 GPR81 -0.18 1.27 0.16 1.27 -0.52 1 2 3 4 5 -1.11 1.11 HS.564475 0.25 0.91 -0.20 -0.44 -0.11 1 2 3 4 5 -1.11 1.11 LOC649073 -0.23 1.48 0.37 1.00 0.25 1 2 3 4 5 -1.11 1.11 HS.544558 -0.06 0.94 -0.17 6.03 -0.13 1 2 3 4 5 -1.11 1.11 LOC139116 0.12 0.41 -0.70 -0.45 -0.85 1 2 3 4 5 -1.11 1.11 LOC644711 0.79 0.87 -0.24 -0.07 -0.51 1 2 3 4 5 -1.11 1.11 HS.571313 -0.46 0.64 -0.47 -0.53 1.56 1 2 3 4 5 -1.11 1.11 LOC651860 0.73 1.07 -0.04 0.22 1.03 1 2 3 4 5 -1.11 1.11 MED12L 0.71 0.57 -0.54 3.60 -0.04 1 2 3 4 5 -1.11 1.11 LOC651568 1.14 0.39 -0.72 2.77 -0.17 1 2 3 4 5 -1.11 1.11 HS.584062 0.18 0.83 -0.28 0.29 0.14 1 2 3 4 5 -1.11 1.11 CHRNA9 -0.37 1.11 0.00 -0.42 2.22 1 2 3 4 5 -1.11 1.11 HS.563984 1.93 0.64 -0.47 1.44 -0.83 1 2 3 4 5 -1.11 1.11 LOC390998 0.91 1.96 0.85 0.04 -0.13 1 2 3 4 5 -1.11 1.11 HS.561410 -0.12 0.81 -0.30 0.17 0.99 1 2 3 4 5 -1.12 1.12 HS.579145 0.11 0.92 -0.20 0.17 0.60 1 2 3 4 5 -1.12 1.12 HS.580860 0.30 1.11 -0.01 0.10 0.52 1 2 3 4 5 -1.12 1.12 HS.573122 1.41 0.99 -0.13 3.95 1.07 1 2 3 4 5 -1.12 1.12 HS.540902 0.38 0.46 -0.65 0.93 0.09 1 2 3 4 5 -1.12 1.12 HS.583869 -0.31 0.39 -0.73 2.00 -0.11 1 2 3 4 5 -1.12 1.12 HS.541603 -0.01 1.08 -0.04 0.08 -0.14 1 2 3 4 5 -1.12 1.12 LOC651361 -0.85 1.18 0.07 0.69 0.39 1 2 3 4 5 -1.12 1.12 HS.571661 -0.52 1.76 0.64 0.25 -0.44 1 2 3 4 5 -1.12 1.12 HS.211136 1.54 2.56 1.44 1.80 1.09 1 2 3 4 5 -1.12 1.12 LOC653464 0.29 1.00 -0.12 -0.07 -0.44 1 2 3 4 5 -1.12 1.12 LOC644592 1.25 0.59 -0.53 -0.10 -0.02 1 2 3 4 5 -1.12 1.12 HS.581880 0.31 0.96 -0.16 0.02 0.20 1 2 3 4 5 -1.12 1.12 LOC650914 -0.50 0.87 -0.25 1.44 2.22 1 2 3 4 5 -1.12 1.12 HS.444808 0.01 0.67 -0.45 0.58 -0.09 1 2 3 4 5 -1.12 1.12 LOC731227 0.65 1.25 0.13 -0.08 0.25 1 2 3 4 5 -1.12 1.12 HS.548227 -0.18 0.98 -0.14 0.61 -0.27 1 2 3 4 5 -1.12 1.12 Table 3 115 HS.544474 -0.01 1.25 0.13 1.08 -0.11 1 2 3 4 5 -1.12 1.12 HS.546001 -1.00 1.24 0.12 0.55 -0.07 1 2 3 4 5 -1.12 1.12 HS.49132 -0.27 0.90 -0.22 0.39 1.29 1 2 3 4 5 -1.12 1.12 HS.541701 1.31 0.20 -0.92 0.21 -0.61 1 2 3 4 5 -1.12 1.12 HS.570284 0.49 1.14 0.01 0.01 0.51 1 2 3 4 5 -1.12 1.12 HS.580536 0.17 0.70 -0.42 -0.39 -0.15 1 2 3 4 5 -1.12 1.12 LOC729047 -0.46 0.35 -0.77 0.65 0.12 1 2 3 4 5 -1.12 1.12 HS.543572 1.20 0.92 -0.21 0.24 -0.57 1 2 3 4 5 -1.12 1.12 HS.541070 0.07 0.10 -1.02 0.43 -0.17 1 2 3 4 5 -1.12 1.12 LOC441178 -0.93 0.19 -0.93 -0.28 0.07 1 2 3 4 5 -1.12 1.12 LOC646422 -0.43 0.63 -0.50 -0.15 -0.54 1 2 3 4 5 -1.13 1.13 HS.541932 -0.65 1.02 -0.11 1.95 0.25 1 2 3 4 5 -1.13 1.13 HS.541649 2.05 -0.13 -1.26 -0.34 -0.51 1 2 3 4 5 -1.13 1.13 LOC646096 0.80 1.37 0.24 -0.53 0.45 1 2 3 4 5 -1.13 1.13 HS.401511 -0.40 0.34 -0.78 0.20 0.20 1 2 3 4 5 -1.13 1.13 MGC15705 -0.16 1.11 -0.02 -0.09 0.51 1 2 3 4 5 -1.13 1.13 HS.125562 -0.69 0.26 -0.86 1.37 -0.30 1 2 3 4 5 -1.13 1.13 HS.542809 4.67 0.94 -0.19 -0.64 -0.06 1 2 3 4 5 -1.13 1.13 HS.539233 0.60 0.91 -0.22 0.27 0.53 1 2 3 4 5 -1.13 1.13 HS.584581 0.05 0.94 -0.19 -0.38 -0.05 1 2 3 4 5 -1.13 1.13 SERPINA13 0.65 0.90 -0.23 1.25 0.02 1 2 3 4 5 -1.13 1.13 TAC1 3.08 0.07 -1.06 1.91 -0.22 1 2 3 4 5 -1.13 1.13 SLC13A1 -0.32 0.97 -0.16 -0.34 0.38 1 2 3 4 5 -1.13 1.13 HS.275545 -0.21 1.08 -0.05 -0.69 1.06 1 2 3 4 5 -1.13 1.13 FOXD4L2 -0.29 0.51 -0.62 -0.30 3.16 1 2 3 4 5 -1.13 1.13 HS.545704 0.84 1.03 -0.10 0.06 0.31 1 2 3 4 5 -1.13 1.13 GALNT7 -0.44 0.81 -0.32 -0.53 -0.97 1 2 3 4 5 -1.13 1.13 HS.563609 -0.49 1.33 0.20 -0.20 -0.13 1 2 3 4 5 -1.13 1.13 GH1 -0.10 2.47 1.34 -0.28 0.10 1 2 3 4 5 -1.13 1.13 LOC644299 -0.29 0.63 -0.50 0.52 -0.43 1 2 3 4 5 -1.13 1.13 HS.242576 -0.61 1.50 0.37 0.55 0.11 1 2 3 4 5 -1.13 1.13 LOC730684 0.90 0.82 -0.31 0.13 0.13 1 2 3 4 5 -1.13 1.13 TAS1R1 -0.72 0.78 -0.35 0.73 3.34 1 2 3 4 5 -1.13 1.13 HS.541025 0.26 1.18 0.04 -0.17 0.08 1 2 3 4 5 -1.13 1.13 HS.201735 2.28 0.65 -0.49 -1.32 -0.49 1 2 3 4 5 -1.13 1.13 LOC644322 1.24 0.70 -0.43 0.20 -0.33 1 2 3 4 5 -1.13 1.13 HS.447309 3.11 0.46 -0.67 -0.38 0.54 1 2 3 4 5 -1.13 1.13 HS.574768 3.30 0.90 -0.23 2.09 1.37 1 2 3 4 5 -1.13 1.13 SPAG8 0.28 0.89 -0.24 1.53 -0.26 1 2 3 4 5 -1.13 1.13 SCN1A -0.26 0.52 -0.61 0.27 -0.19 1 2 3 4 5 -1.13 1.13 LOC646584 0.37 0.85 -0.28 -0.89 -0.28 1 2 3 4 5 -1.13 1.13 HS.133438 -0.51 0.80 -0.33 -0.70 1.37 1 2 3 4 5 -1.13 1.13 LOC643133 -0.75 0.85 -0.28 -0.12 1.37 1 2 3 4 5 -1.13 1.13 ALDH1L1 2.12 0.43 -0.70 -1.97 -1.50 1 2 3 4 5 -1.13 1.13 LOC653971 1.06 0.16 -0.97 0.80 0.12 1 2 3 4 5 -1.13 1.13 HS.245738 -0.54 0.52 -0.61 -0.14 -0.30 1 2 3 4 5 -1.13 1.13 HS.538346 -0.29 2.64 1.50 1.84 3.34 1 2 3 4 5 -1.13 1.13 HS.562325 -1.21 -0.03 -1.16 -0.78 1.23 1 2 3 4 5 -1.13 1.13 LOC653554 -0.67 0.85 -0.28 0.06 0.25 1 2 3 4 5 -1.13 1.13 Table 3 116 PDC -0.15 0.71 -0.43 0.60 -0.33 1 2 3 4 5 -1.13 1.13 HS.578061 0.95 1.38 0.25 0.64 0.98 1 2 3 4 5 -1.13 1.13 SH3GL3 2.16 0.96 -0.18 0.42 -0.05 1 2 3 4 5 -1.13 1.13 LOC645254 -0.55 1.94 0.81 -0.11 1.81 1 2 3 4 5 -1.14 1.14 HS.539579 2.20 0.12 -1.01 -0.47 -0.25 1 2 3 4 5 -1.14 1.14 C10ORF30 1.50 0.70 -0.43 -0.22 -0.38 1 2 3 4 5 -1.14 1.14 LOC650708 -0.09 1.13 -0.01 -0.17 0.25 1 2 3 4 5 -1.14 1.14 HS.578470 1.44 0.41 -0.73 -0.57 0.94 1 2 3 4 5 -1.14 1.14 HS.580363 1.73 0.01 -1.12 1.50 -0.38 1 2 3 4 5 -1.14 1.14 HS.571467 1.02 0.59 -0.54 -0.25 0.61 1 2 3 4 5 -1.14 1.14 HS.566782 0.32 0.31 -0.83 0.71 3.45 1 2 3 4 5 -1.14 1.14 HS.574749 -0.18 0.85 -0.29 0.10 -0.25 1 2 3 4 5 -1.14 1.14 CCDC105 1.73 0.61 -0.52 -1.30 -0.22 1 2 3 4 5 -1.14 1.14 APOC4 1.15 0.82 -0.32 0.19 0.09 1 2 3 4 5 -1.14 1.14 HS.541248 0.68 0.98 -0.16 -0.04 0.67 1 2 3 4 5 -1.14 1.14 OTOS -1.65 -0.09 -1.23 2.59 -1.78 1 2 3 4 5 -1.14 1.14 LOC642720 -0.71 0.92 -0.21 -0.18 0.28 1 2 3 4 5 -1.14 1.14 LOC441282 -0.27 0.33 -0.80 -0.49 -0.01 1 2 3 4 5 -1.14 1.14 CYP2C18 -0.03 0.99 -0.15 0.12 -0.65 1 2 3 4 5 -1.14 1.14 LOC286187 -0.69 0.76 -0.37 -0.79 -0.42 1 2 3 4 5 -1.14 1.14 LOC729096 0.59 0.81 -0.33 -0.36 -0.57 1 2 3 4 5 -1.14 1.14 PAPPA2 -0.49 0.69 -0.45 -0.61 -1.42 1 2 3 4 5 -1.14 1.14 HS.544406 -0.52 0.88 -0.26 -0.68 0.65 1 2 3 4 5 -1.14 1.14 LOC646903 1.21 1.48 0.34 1.73 -0.67 1 2 3 4 5 -1.14 1.14 HS.436654 -0.12; 1.30 0.16 0.12 0.29 1 2 3 4 5 -1.14 1.14 HS.546047 -0.07 r 0.89 -0.25 0.77 -0.16 1 2 3 4 5 -1.14 1.14 HS.566366 -0.53 0.50 -0.64 -0.46 -0.42 1 2 3 4 5 -1.14 1.14 GUCY1A2 2.35; 0.88 -0.26 -0.61 1.23 1 2 3 4 5 -1.14 1.14 LOC388210 0.16; 0.89 -0.25 -0.24 -0.16 1 2 3 4 5 -1.14 1.14 HS.551220 1.22: 0.92 -0.22 -1.16 -1.37 1 2 3 4 5 -1.14 1.14 LIMD1 0.00 0.21 -0.93 -0.54 1.01 1 2 3 4 5 -1.14 1.14 HS.538611 0.10 1.26 0.12 0.75 0.21 1 2 3 4 5 -1.14 1.14 HS.29792 -0.21 0.71 -0.44 -0.40 -0.25 1 2 3 4 5 -1.14 1.14 HS.579967 0.69 0.91 -0.23 -0.12 -0.38 1 2 3 4 5 -1.14 1.14 HS.162181 0.38 0.66 -0.49 -0.13 0.35 1 2 3 4 5 -1.14 1.14 LOC641958 -0.30 0.75 -0.39 -0.84 0.07 1 2 3 4 5 -1.14 1.14 LOC649703 -0.31 0.74 -0.41 1.36 -0.25 1 2 3 4 5 -1.14 1.14 HS.538418 -0.03 0.44 -0.70 -0.46 -0.88 1 2 3 4 5 -1.15 1.15 HS.563124 1.86 0.86 -0.29 0.03 -0.50 1 2 3 4 5 -1.15 1.15 HS.551043 0.20 0.85 -0.30 0.03 -0.14 1 2 3 4 5 -1.15 1.15 LOC441459 0.47 0.45 -0.69 0.09 1.00 1 2 3 4 5 -1.15 1.15 HS.543382 0.34 0.45 -0.69 0.59 2.48 1 2 3 4 5 -1.15 1.15 HS.145985 -0.17 1.08 -0.06 0.04 -0.32 1 2 3 4 5 -1.15 1.15 HS.204481 0.23 1.13 -0.01 0.32 3.80 1 2 3 4 5 -1.15 1.15 HS.539305 -0.80 0.61 -0.54 0.57 -0.71 1 2 3 4 5 -1.15 1.15 HS.545467 0.17 0.67 -0.47 -0.60 -0.20 1 2 3 4 5 -1.15 1.15 HS.422913 -0.23 0.90 -0.25 -0.21 1.44 1 2 3 4 5 -1.15 1.15 OR8J3 -0.34 0.74 -0.41 -0.11 0.57 1 2 3 4 5 -1.15 1.15 LOC643363 -0.48 0.82 -0.33 0.12 -0.10 1 2 3 4 5 -1.15 1.15 Table 3 117 HS.578390 -0.41 1.20 0.05 0.20 0.00 1 2 3 4 5 -1.15 1.15 HS.582832 -0.12 1.03 -0.12 0.20 -0.01 1 2 3 4 5 -1.15 1.15 HS.552155 -0.03 1.34 0.19 0.07 0.28 1 2 3 4 5 -1.15 1.15 HS.545251 -0.12 1.11 -0.04 0.61 0.53 1 2 3 4 5 -1.15 1.15 LOC654010 -0.32 0.38 -0.77 0.42 0.17 1 2 3 4 5 -1.15 1.15 HS.567068 0.76 0.32 -0.83 -0.57 1.45 1 2 3 4 5 -1.15 1.15 PCDHGA11 -0.40 -0.29 -1.44 0.06 4.27 1 2 3 4 5 -1.15 1.15 OR6B3 -0.33 0.80 -0.35 -0.23 -0.34 1 2 3 4 5 -1.15 1.15 HS.403212 1.12 0.72 -0.43 -0.17 -0.48 1 2 3 4 5 -1.15 1.15 LOC440434 0.11 1.07 -0.08 -0.09 0.67 1 2 3 4 5 -1.15 1.15 HS.574976 -0.18 0.55 -0.60 0.42 -0.12 1 2 3 4 5 -1.15 1.15 HTR1A -0.83 -0.05 -1.20 -0.90 0.15 1 2 3 4 5 -1.15 1.15 HS.581906 0.14 1.45 0.30 0.64 0.29 1 2 3 4 5 -1.15 1.15 HS.26409 0.44 0.94 -0.21 2.51 0.25 1 2 3 4 5 -1.15 1.15 HS.266041 -0.27 2.51 1.36 -1.22 -0.68 1 2 3 4 5 -1.15 1.15 BTN2A3 -0.13 0.75 -0.40 0.26 -0.33 1 2 3 4 5 -1.15 1.15 LOC642381 -0.09 1.29 0.14 0.52 -0.18 1 2 3 4 5 -1.15 1.15 PH0X2A 2.71 0.91 -0.24 -0.12 0.20 1 2 3 4 5 -1.15 1.15 HS.573685 -0.75 0.90 -0.25 3.84 1.52 1 2 3 4 5 -1.15 1.15 HS.565715 0.16 0.54 -0.61 3.09 3.67 1 2 3 4 5 -1.15 1.15 VCX-C -0.55 0.94 -0.21 -0.68 -0.04 1 2 3 4 5 -1.15 1.15 S0X21 0.33 1.02 -0.14 1.10 -0.67 1 2 3 4 5 -1.15 1.15 HS.58384 2.07 1.17 0.01 -0.14 -0.22 1 2 3 4 5 -1.15 1.15 LOC647621 0.08 0.84 -0.31 -0.21 0.22 1 2 3 4 5 -1.15 1.15 HS.553076 0.47 0.24 -0.91 -0.73 0.78 1 2 3 4 5 -1.15 1.15 HS.515976 0.73 1.10 -0.05 -0.22 0.90 1 2 3 4 5 -1.15 1.15 LOC642731 -0.10 2.25 1.10 -0.75 -0.32 1 2 3 4 5 -1.15 1.15 HS.539672 1.58 0.60 -0.55 -0.30 -0.95 1 2 3 4 5 -1.16 1.16 HS.507668 -0.61 0.64 -0.51 1.98 -0.01 1 2 3 4 5 -1.16 1.16 BA F2 0.74 1.45 0.29 0.39 -0.01 1 2 3 4 5 -1.16 1.16 TFAP2D -0.72 2.63 1.48 0.25 0.67 1 2 3 4 5 -1.16 1.16 HS.581822 6.03 0.73 -0.43 -0.42 -0.52 1 2 3 4 5 -1.16 1.16 HS.578051 -0.77 1.04 -0.12 -0.26 .1.03 1 2 3 4 5 -1.16 1.16 HS.369950 -0.01 1.45 0.29 1.71 0.75 1 2 3 4 5 -1.16 1.16 HS.207114 0.02 1.55 0.39 0.98 -0.23 1 2 3 4 5 -1.16 1.16 C100RF120 1.44 -0.19 -1.35 0.53 0.56 1 2 3 4 5 -1.16 1.16 HS.458426 -0.43 2.00 0.84 0.50 4.02 1 2 3 4 5 -1.16 1.16 PPIL4 -0.56 0.52 -0.64 -0.05 -1.10 1 2 3 4 5 -1.16 1.16 HS.575194 -0.15 1.22 0.06 0.15 -0.25 1 2 3 4 5 -1.16 1.16 HEPH 1.98 -1.12 -2.28 0.00 -3.25 1 2 3 4 5 -1.16 1.16 KRTAP19-2 0.52 0.94 -0.21 0.91 3.39 1 2 3 4 5 -1.16 1.16 HS.23298 -0.38 0.77 -0.39 -0.79 1.64 1 2 3 4 5 -1.16 1.16 HS.132540 1.47 1.58 0.42 -0.13 0.93 1 2 3 4 5 -1.16 1.16 LOC648645 1.36 0.68 -0.48 -0.28 1.41 1 2 3 4 5 -1.16 1.16 HS.527503 4.90 -0.61 -1.77 -2.00 1.08 1 2 3 4 5 -1.16 1.16 HS.439865 -0.17 1.35 0.19 0.03 0.29 1 2 3 4 5 -1.16 1.16 HS.565615 0.58 1.82 0.66 0.22 1.20 1 2 3 4 5 -1.16 1.16 PRELID2 2.36 0.96 -0.21 -0.58 -0.39 1 2 3 4 5 -1.16 1.16 LOC647206 0.43 1.28 0.12 -0.38 -0.33 1 2 3 4 5 -1.16 1.16 Table 3 118 HS.539277 -0.13 0.69 -0.47 0.76 -0.78 1 2 3 4 5 -1.16 1.16 HS.541717 0.53 1.04 -0.13 -0.24 -0.21 1 2 3 4 5 -1.16 1.16 C6ORF103 0.04 0.89 -0.28 -0.22 0.11 1 2 3 4 5 -1.16 1.16 LRIG3 2.45 0.17 -1.00 5.04 0.47 1 2 3 4 5 -1.16 1.16 HS.547262 0.19 0.79 -0.37 0.76 1.45 1 2 3 4 5 -1.16 1.16 HS.566842 0.73 0.68 -0.48 -0.03 -0.24 1 2 3 4 5 -1.16 1.16 SNAP91 -0.64 1.82 0.66 1.65 1.68 1 2 3 4 5 -1.16 1.16 HS.150738 1.01 0.99 -0.17 0.15 0.04 1 2 3 4 5 -1.16 1.16 HS.568549 -0.43 0.84 -0.32 0.41 0.05 1 2 3 4 5 -1.16 1.16 OCM -1.40 1.23 0.06 3.65 2.19 1 2 3 4 5 -1.16 1.16 ZPBP2 -0.63 0.38 -0.78 0.07 0.38 1 2 3 4 5 -1.16 1.16 PDE10A 3.77 1.81 0.65 -0.85 0.41 1 2 3 4 5 -1.16 1.16 HS.577703 -0.43 1.01 -0.16 -0.26 0.48 1 2 3 4 5 -1.17 1.17 HS.583467 0.59 0.70 -0.47 0.24 -0.06 1 2 3 4 5 -1.17 1.17 HS.132249 0.07 0.40 -0.77 0.56 2.04 1 2 3 4 5 -1.17 1.17 PCDHGA6 0.40 1.02 -0.14 -0.76 -0.63 1 2 3 4 5 -1.17 1.17 HS.553998 0.04 0.49 -0.67 -0.60 0.71 1 2 3 4 5 -1.17 1.17 LOC652683 -0.53 1.45 0.28 0.21 -0.37 1 2 3 4 5 -1.17 1.17 ACSM5 -0.19 1.45 0.29 0.36 -0.44 1 2 3 4 5 -1.17 1.17 LOC649255 -0.61 1.47 0.30 1.50 0.09 1 2 3 4 5 -1.17 1.17 ZNF625 0.03 1.10 -0.07 -0.02 -0.07 1 2 3 4 5 -1.17 1.17 HS.543028 0.37 2.50 1.33 5.10 -0.23 1 2 3 4 5 -1.17 1.17 FU43752 0.17 1.17 0.00 0.05 -0.10 1 2 3 4 5 -1.17 1.17 HS.348809 -1.01 1.25 0.08 0.31 0.71 1 2 3 4 5 -1.17 1.17 LOC650631 -0.92 1.12 -0.05 1.27 -0.74 1 2 3 4 5 -1.17 1.17 HS.563007 -0.04 0.88 -0.29 0.67 -0.69 1 2 3 4 5 -1.17 1.17 LOC399939 -0.69 2.21 1.04 2.38 0.98 1 2 3 4 5 -1.17 1.17 HS.577627 1.63 1.25 0.08 -0.62 1.07 1 2 3 4 5 -1.17 1.17 LOC651091 0.70 1.03 -0.14 1.06 -0.04 1 2 3 4 5 -1.17 1.17 HS.543776 1.58 1.17 0.00 0.37 0.77 1 2 3 4 5 -1.17 1.17 LOC654127 0.32 1.74 0.57 0.57 0.18 1 2 3 4 5 -1.17 1.17 HS.446299 1.53 1.03 -0.14 -0.40 0.44 1 2 3 4 5 -1.17 1.17 LOC642530 -0.48 1.07 -0.11 -0.75 0.67 1 2 3 4 5 -1.17 1.17 HTR3A -0.03 1.06 -0.11 -0.11 -0.05 1 2 3 4 5 -1.17 1.17 LOC390712 2.34 0.72 -0.45 5.08 -1.54 1 2 3 4 5 -1.17 1.17 C210RF129 -0.88 0.45 -0.72 4.98 -0.20 1 2 3 4 5 -1.17 1.17 HS.557679 0.00 0.38 -0.79 -0.72 0.09 1 2 3 4 5 -1.17 1.17 HS.545479 0.72 0.76 -0.41 -0.56 1.51 1 2 3 4 5 -1.17 1.17 LOC731670 0.27 1.02 -0.15 -0.12 1.66 1 2 3 4 5 -1.17 1.17 LOC388117 -0.79 -0.35 -1.53 7.69 0.23 1 2 3 4 5 -1.17 1.17 LOC643748 -0.78 1.32 0.14 0.27 -1.02 1 2 3 4 5 -1.17 1.17 HS.547332 -0.05 0.97 -0.21 -0.16 -0.11 1 2 3 4 5 -1.17 1.17 LOC644993 -0.13 1.07 -0.10 0.93 -0.26 1 2 3 4 5 -1.17 1.17 LOC402145 -0.49 0.55 -0.62 1.40 0.58 1 2 3 4 5 -1.17 1.17 LOC643699 -0.44 0.37 -0.81 -0.05 0.84 1 2 3 4 5 -1.17 1.17 LOC643604 -0.14 1.43 0.26 -0.30 -0.38 1 2 3 4 5 -1.18 1.18 NTF5 1.24 1.01 -0.16 0.31 0.37 1 2 3 4 5 -1.18 1.18 LOC646307 1.81 1.09 -0.08 -0.52 -0.15 1 2 3 4 5 -1.18 1.18 HS.572752 0.57 0.60 -0.57 0.03 -0.39 1 2 3 4 5 -1.18 1.18 Table 3 119 LOC650167 -0.09 1.11 -0.07 0.81 -0.25 1 2 3 4 5 -1.18 1.18 SOX6 6.15 1.58 0.40 3.44 1.50 1 2 3 4 5 -1.18 1.18 PLA2G3 0.09 0.66 -0.51 -0.19 -0.74 1 2 3 4 5 -1.18 1.18 HS.105821 -0.59 1.29 0.11 0.58 1.19 1 2 3 4 5 -1.18 1.18 HS.557981 -0.32 0.47 -0.70 0.35 0.01 1 2 3 4 5 -1.18 1.18 C14ORF105 -0.10 1.69 0.51 1.77 -0.55 1 2 3 4 5 -1.18 1.18 LOC646458 -0.05 0.73 -0.45 0.08 0.17 1 2 3 4 5 -1.18 1.18 DAB2IP -1.08 0.65 -0.53 2.54 -0.34 1 2 3 4 5 -1.18 1.18 HS.208452 0.22 0.83 -0.35 -0.39 0.59 1 2 3 4 5 -1.18 1.18 HS.540469 -0.17 0.83 -0.35 -0.24 0.09 1 2 3 4 5 -1.18 1.18 HS.132528 1.07 0.77 -0.41 1.26 0.61 1 2 3 4 5 -1.18 1.18 D T3 1.04 0.64 -0.54 -0.97 0.45 1 2 3 4 5 -1.18 1.18 HS.584366 0.27 1.49 0.31 -0.20 0.29 1 2 3 4 5 -1.18 1.18 HS.504647 0.60 0.28 -0.90 -0.54 0.41 1 2 3 4 5 -1.18 1.18 LOC651315 2.63 0.54 -0.64 -1.68 0.74 1 2 3 4 5 -1.18 1.18 HS.564600 -0.42 0.61 -0.58 -0.37 1.60 1 2 3 4 5 -1.18 1.18 HS.543118 0.00 0.89 -0.29 -0.33 0.71 1 2 3 4 5 -1.18 1.18 ETV1 -0.17 2.37 1.19 5.81 1.39 1 2 3 4 5 -1.18 1.18 HS.571139 -0.73 0.92 -0.27 -0.08 0.51 1 2 3 4 -1.18 1.18 HS.578577 -0.72 0.80 -0.38 1.63 -0.43 1 2 3 4 5 -1.18 1.18 HS.538428 -0.10 1.05 -0.13 -0.13 -0.33 1 2 3 4 5 -1.18 1.18 HS.539011 -0.42 0.95 -0.23 -0.12 0.19 1 2 3 4 5 -1.18 1.18 FU38379 0.43 2.93 1.74 3.52 3.79 1 2 3 4 5 -1.18 1.18 HS.544539 0.15 -0.22 -1.40 2.02 -0.88 1 2 3 4 5 -1.18 1.18 SYNPR 0.17 0.20 -0.98 -1.32 7.46 1 2 3 4 5 -1.18 1.18 LOC440292 0.01 1.05 -0.14 0.25 0.78 1 2 3 4 5 -1.18 1.18 HS.578123 -0.32 0.76 -0.42 -0.19 0.29 1 2 3 4 5 -1.18 1.18 KCNB2 0.17 1.75 0.56 -0.50 0.50 1 2 3 4 5 -1.18 1.18 HS.292188 0.48 0.64 -0.54 2.05 0.60 1 2 3 4 5 -1.19 1.19 HS.564514 -1.01 0.96 -0.23 -0.31 2.93 1 2 3 4 5 -1.19 1.19 HS.566675 -0.96 2.84 1.65 -0.64 0.81 1 2 3 4 5 -1.19 1.19 WFDC6 0.41 0.74 -0.44 0.19 -1.08 1 2 3 4 5 -1.19 1.19 HS.579518 1.55 0.50 -0.69 0.39 0.08 1 2 3 4 5 -1.19 1.19 HS.407358 -0.04 0.17 -1.01 0.66 -0.01 1 2 3 4 5 -1.19 1.19 CPZ -0.08 0.55 -0.63 0.19 1.25 1 2 3 4 5 -1.19 1.19 LOC649951 1.30 0.84 -0.35 -0.07 0.97 1 2 3 4 5 -1.19 1.19 LOC651530 -0.78 0.54 -0.64 -0.15 -0.99 1 2 3 4 5 -1.19 1.19 HS.559609 0.38 1.14 -0.05 -0.23 -0.19 1 2 3 4 5 -1.19 1.19 PHACTR3 -0.77 1.31 0.13 -0.45 -0.43 1 2 3 4 5 -1.19 1.19 LOC645769 -0.43 1.66 0.47 0.21 -1.02 1 2 3 4 5 -1.19 1.19 HS.577761 0.28 1.44 0.25 -0.05 0.04 1 2 3 4 5 -1.19 1.19 C120RF56 0.26 1.08 -0.11 -0.44 -0.32 1 2 3 4 5 -1.19 1.19 FU46010 -0.47 1.09 -0.10 1.81 -1.35 1 2 3 4 5 -1.19 1.19 NPAS4 -0.53 0.55 -0.64 0.15 0.21 1 2 3 4 5 -1.19 1.19 HS.85989 0.05 0.88 -0.31 -0.13 0.15 1 2 3 4 5 -1.19 1.19 LOC402641 0.35 1.10 -0.09 -0.11 0.17 1 2 3 4 5 -1.19 1.19 HS.526753 0.46 0.61 -0.58 0.20 -0.82 1 2 3 4 5 -1.19 1.19 LOC391004 0.36 0.81 -0.38 -0.25 2.64 1 2 3 4 5 -1.19 1.19 LOC649137 -0.70 0.64 -0.55 -0.57 0.81 1 2 3 4 5 -1.19 1.19 Table 3 120 LOC653733 0.62 0.67 -0.52 0.17 -0.40 1 2 3 4 5 -1.19 1.19 HS.244777 1.48 1.07 -0.12 0.15 0.11 1 2 3 4 5 -1.19 1.19 LOC646036 0.86 0.71 -0.48 -0.09 -0.72 1 2 3 4 5 -1.19 1.19 HS.579561 -0.45 0.86 -0.33 0.10 0.52 1 2 3 4 5 -1.19 1.19 HS.276379 0.01 0.32 -0.87 0.45 -0.88 1 2 3 4 5 -1.19 1.19 HS.474452 2.12 1.32 0.13 -0.90 -0.14 1 2 3 4 5 -1.19 1.19 O P -0.37 0.47 -0.72 -0.59 0.91 1 2 3 4 5 -1.19 1.19 HS.565111 -0.30 0.55 -0.64 0.84 -0.68 1 2 3 4 5 -1.19 1.19 HS.128837 -0.66 1.60 0.40 -0.29 -0.04 1 2 3 4 5 -1.19 1.19 HS.560598 0.28 1.23 0.04 0.22 -0.15 1 2 3 4 5 -1.19 1.19 RAB6C -0.21 0.06 -1.14 -0.01 -0.79 1 2 3 4 5 -1.19 1.19 HS.539892 -0.13 1.31 0.12 0.68 -0.17 1 2 3 4 5 -1.19 1.19 LOC648170 -0.31 1.27 0.07 0.12 0.00 1 2 3 4 5 -1.19 1.19 HS.545491 -0.68 0.53 -0.67 2.56 -0.68 1 2 3 4 5 -1.19 1.19 FAM83E 0.33 0.79 -0.41 -0.30 -0.15 1 2 3 4 5 -1.19 1.19 MTNR1B 0.30 0.83 -0.37 0.11 0.92 1 2 3 4 5 -1.19 1.19 HS.445169 -0.78 0.51 -0.69 -1.05 1.26 1 2 3 4 5 -1.19 1.19 HS.539918 2.27 0.91 -0.28 -0.31 1.24 1 2 3 4 5 -1.19 1.19 HS.544484 0.50 0.66 -0.53 -0.26 0.94 1 2 3 4 5 -1.20 1.20 MSLN -0.02 1.10 -0.10 0.09 0.27 1 2 3 4 5 -1.20 1.20 HS.123396 0.05 1.21 0.01 0.21 -0.11 1 2 3 4 5 -1.20 1.20 HS.76704 1.12, 1.58 0.38 0.06 0.25 1 2 3 4 5 -1.20 1.20 HS.539882 0.10 1.09 -0.11 -0.29 0.17 1 2 3 4 5 -1.20 1.20 HS.445613 -0.13; 0.86 -0.34 0.54 -0.15 1 2 3 4 5 -1.20 1.20 HS.550715 0.01 0.36 -0.84 0.38 0.41 1 2 3 4 5 -1.20 1.20 HS.145920 -0.07 1.28 0.08 -0.02 -0.10 1 2 3 4 5 -1.20 1.20 HS.541900 -0.02 0.74 -0.46 -0.43 1.32 1 2 3 4 5 -1.20 1.20 HS.541095 0.49 0.82 -0.38 -0.29 -0.65 1 2 3 4 5 -1.20 1.20 PRPF40B 0.13 1.33 0.13 -0.10 -0.02 1 2 3 4 5 -1.20 1.20 HS.384594 0.09 0.78 -0.42 -0.22 -0.26 1 2 3 4 5 -1.20 1.20 HS.156222 0.02 0.95 -0.25 -0.22 -0.20 1 2 3 4 5 -1.20 1.20 LOC650862 -0.79 1.68 0.48 0.36 -0.51 1 2 3 4 5 -1.20 1.20 HS.545808 0.03 0.92 -0.28 0.64 0.19 1 2 3 4 5 -1.20 1.20 HS.545666 -0.06 0.98 -0.22 0.03 -0.18 1 2 3 4 5 -1.20 1.20 HS.579487 0.42 1.01 -0.19 1.14 -0.15 1 2 3 4 5 -1.20 1.20 CDH12 -0.13 0.47 -0.73 -1.10 -0.55 1 2 3 4 5 -1.20 1.20 HS.583070 -0.46 0.98 -0.22 1.02 -0.52 1 2 3 4 5 -1.20 1.20 SYT9 -0.73 1.21 0.01 0.75 -0.02 1 2 3 4 5 -1.20 1.20 JPH1 1.81 1.00 -0.20 -1.34 2.00 1 2 3 4 5 -1.20 1.20 HS.572007 1.12 1.23 0.03 -0.02 0.07 1 2 3 4 5 -1.20 1.20 HS.577626 -0.01 0.96 -0.25 0.02 -0.86 1 2 3 4 5 -1.20 1.20 GNRHR -0.89 0.19 -1.02 1.90 0.77 1 2 3 4 5 -1.20 1.20 HS.278285 -0.29 1.26 0.06 0.63 0.72 1 2 3 4 5 -1.20 1.20 LOC654023 0.32 0.98 -0.22 -0.18 -0.31 1 2 3 4 5 -1.20 1.20 GSTM1L -0.49 1.07 -0.14 0.48 0.41 1 2 3 4 5 -1.20 1.20 ABCC8 0.63 0.88 -0.33 5.49 0.59 1 2 3 4 5 -1.20 1.20 HS.579516 0.95 1.14 -0.07 0.45 -0.17 1 2 3 4 5 -1.20 1.20 HS.580436 0.94 0.92 -0.28 -0.30 -0.22 1 2 3 4 5 -1.20 1.20 HS.555533 -0.27 1.11 -0.09 2.94 0.20 1 2 3 4 5 -1.20 1.20 Table 3 121 HS.434413 2.18 1.04 -0.16 -0.09 0.19 1 2 3 4 5 -1.21 1.21 LOC644371 0.49 1.87 0.66 -0.15 -0.28 1 2 3 4 5 -1.21 1.21 HS.445324 3.35 0.37 -0.83 -0.49 -0.96 1 2 3 4 5 -1.21 1.21 HS.337803 0.24 0.98 -0.23 0.47 -1.08 1 2 3 4 5 -1.21 1.21 PTPN20B 2.05 0.79 -0.41 -0.25 1.41 1 2 3 4 5 -1.21 1.21 HS.539775 1.29 1.87 0.66 -0.04 -0.05 1 2 3 4 5 -1.21 1.21 HS.533995 0.25 0.67 -0.54 -0.62 1.01 1 2 3 4 5 -1.21 1.21 HS.445855 -0.05 1.04 -0.17 -0.01 -0.10 1 2 3 4 5 -1.21 1.21 HS.576064 -0.63 0.55 -0.66 -0.21 1.13 1 2 3 4 5 -1.21 1.21 PAQR5 -0.11 0.89 -0.32 -0.31 -0.17 1 2 3 4 5 -1.21 1.21 HS.146952 -0.20 1.63 0.42 -0.07 1.75 1 2 3 4 5 -1.21 1.21 HS.563041 0.44 2.19 0.98 0.59 0.40 1 2 3 4 5 -1.21 1.21 HS.112954 0.82 0.96 -0.24 1.40 -0.36 1 2 3 4 5 -1.21 1.21 HIGD2BP 1.78 0.48 -0.73 -0.65 -0.89 1 2 3 4 5 -1.21 1.21 HS.382317 -1.07 0.43 -0.78 -0.03 6.12 1 2 3 4 5 -1.21 1.21 HS.566766 -0.26 0.87 -0.34 -0.14 0.38 1 2 3 4 5 -1.21 1.21 HS.569303 -0.75 1.95 0.74 2.58 2.70 1 2 3 4 5 -1.21 1.21 MAGEC3 0.78 0.85 -0.36 1.18 -0.75 1 2 3 4 5 -1.21 1.21 LOC442117 -0.12 -0.60 -1.81 -0.24 2.04 1 2 3 4 5 -1.21 1.21 GPR158L1 2.59 1.39 0.18 2.25 -0.27 1 2 3 4 5 -1.21 1.21 HS.131275 2.08 1.66 0.45 0.37 0.58 1 2 3 4 5 -1.21 1.21 LOC729351 -0.26 1.84 0.63 5.02 0.00 1 2 3 4 5 -1.21 1.21 FU35776 -0.05 0.61 -0.60 -0.49 -0.10 1 2 3 4 5 -1.21 1.21 PHF6 1.07 1.13 -0.08 -0.32 -0.20 1 2 3 4 5 -1.21 1.21 HS.550028 -0.35 0.77 -0.44 0.25 -0.37 1 2 3 4 5 -1.21 1.21 NTF3 -0.81 0.77 -0.45 1.50 0.53 1 2 3 4 5 -1.21 1.21 PS AL -0.33, 0.24 -0.97 2.78 -0.42 1 2 3 4 5 -1.21 1.21 HS.549952 -0.88 0.30 -0.91 2.91 -1.57 1 2 3 4 5 -1.21 1.21 CYP4X1 -0.32 0.45 -0.77 -1.26 -0.35 1 2 3 4 5 -1.21 1.21 HS.573811 2.69 0.96 -0.25 -0.38 -0.32 1 2 3 4 5 -1.21 1.21 HS. 147481 1.33 1.13 -0.09 0.22 1.25 1 2 3 4 5 -1.21 1.21 TAS2R60 0.10 0.53 -0.68 0.10 -0.94 1 2 3 4 5 -1.21 1.21 LOC643412 0.64 0.94 -0.28 1.05 0.01 1 2 3 4 5 -1.21 1.21 LOC729777 -0.72 0.74 -0.47 0.09 0.40 1 2 3 4 5 -1.22 1.22 HS.559929 0.48 1.30 0.08 1.31 0.60 1 2 3 4 5 -1.22 1.22 LOC644766 1.06 1.34 0.12 -0.31 -0.53 1 2 3 4 5 -1.22 1.22 C10RF138 -0.94 1.41 0.19 0.64 2.03 1 2 3 4 5 -1.22 1.22 ESPN 1.23 1.21 -0.01 -0.27 0.32 1 2 3 4 5 -1.22 1.22 NR5A1 1.13, 0.31 -0.91 -0.63 -0.76 1 2 3 4 5 -1.22 1.22 ITIH2 0.38 0.69 -0.53 1.11 -0.32 1 2 3 4 5 -1.22 1.22 LOC646596 -0.31 0.64 -0.58 -1.02 0.94 1 2 3 4 5 -1.22 1.22 LOC441869 -0.75 1.23 0.01 0.42 0.45 1 2 3 4 5 -1.22 1.22 LOC647785 0.40 0.52 -0.70 -0.78 -0.49 1 2 3 4 5 -1.22 1.22 HS.527361 0.48 1.13 -0.09 1.60 0.81 1 2 3 4 5 -1.22 1.22 HS.563207 0.29 1.77 0.55 -0.52 -0.17 1 2 3 4 5 -1.22 1.22 SPARCL1 1.23 1.30 0.08 0.18 1.47 1 2 3 4 5 -1.22 1.22 HS.580535 1.14 0.85 -0.37 -1.03 1.08 1 2 3 4 5 -1.22 1.22 HS.553134 -0.18 1.57 0.36 0.01 0.17 1 2 3 4 5 -1.22 1.22 LOC440291 0.10 0.82 -0.40 -0.12 0.58 1 2 3 4 5 -1.22 1.22 Table 3 122 O M2 -0.53 1.01 -0.21 -0.45 0.07 1 2 3 4 5 -1.22 1.22 HS.135081 -0.47 0.82 -0.39 0.74 0.61 1 2 3 4 5 -1.22 1.22 HS.575465 3.74 0.84 -0.38 0.54 -0.60 1 2 3 4 5 -1.22 1.22 ATP6V0D2 0.37 1.11 -0.11 0.66 2.32 1 2 3 4 5 -1.22 1.22 HS.560876 1.95 1.16 -0.06 1.20 1.04 1 2 3 4 5 -1.22 1.22 HS.563502 -0.30 0.93 -0.29 0.29 -0.42 1 2 3 4 5 -1.22 1.22 HS.554396 -0.85 0.82 -0.40 0.77 -0.66 1 2 3 4 5 -1.22 1.22 HS.553344 0.68 0.72 -0.50 0.20 2.06 1 2 3 4 5 -1.22 1.22 BMP10 5.08 -0.07 -1.29 -0.92 0.15 1 2 3 4 5 -1.22 1.22 STARD4 0.23 0.81 -0.41 -0.38 -0.72 1 2 3 4 5 -1.22 1.22 HS.583440 0.72 1.70 0.47 0.52 0.05 1 2 3 4 5 -1.22 1.22 HS.550355 -0.27 0.80 -0.42 -0.04 0.78 1 2 3 4 5 -1.22 1.22 HS.127545 -0.19 1.44 0.21 -0.28 -0.11 1 2 3 4 5 -1.22 1.22 HS.518926 1.41 0.88 -0.34 -0.10 1.34 1 2 3 4 5 -1.22 1.22 HS.579243 0.03 0.42 -0.80 1.67 -0.32 1 2 3 4 5 -1.22 1.22 HS.564410 -0.18 1.07 -0.16 0.32 0.05 1 2 3 4 5 -1.23 1.23 GRIN2D 2.16 2.53 1.31 0.26 1.85 1 2 3 4 5 -1.23 1.23 LOC286528 1.17 1.06 -0.16 0.13 0.13 1 2 3 4 5 -1.23 1.23 HS.564755 1.24 1.24 0.01 0.50 0.86 1 2 3 4 5 -1.23 1.23 HS.528452 -0.52 1.53 0.31 -0.06 -0.50 1 2 3 4 5 -1.23 1.23 TRIM50 4.27 1.03 -0.19 -0.18 -0.04 1 2 3 4 5 -1.23 1.23 HS.538819 1.06 0.56 -0.67 1.21 0.37 1 2 3 4 5 -1.23 1.23 PLAC1L -0.86 1.43 0.20 2.11 3.13 1 2 3 4 5 -1.23 1.23 FAM130A2 2.64 1.22 -0.01 -0.68 0.16 1 2 3 4 5 -1.23 1.23 HS.538654 -0.16 1.01 -0.22 0.55 -0.25 1 2 3 4 5 -1.23 1.23 HS.543910 -0.05 1.12 -0.11 0.04 0.02 1 2 3 4 5 -1.23 1.23 HS.153941 -0.05 1.11 -0.12 0.01 0.71 1 2 3 4 5 -1.23 1.23 LOC645871 1.07 0.86 -0.37 1.22 1.19 1 2 3 4 5 -1.23 1.23 H2BFXP -0.13 1.84 0.61 -1.38 0.82 1 2 3 4 5 -1.23 1.23 HS.99250 5.24 1.00 -0.23 -0.62 1.00 1 2 3 4 5 -1.23 1.23 HS.254690 -0.68 0.72 -0.51 0.75 0.20 1 2 3 4 5 -1.23 1.23 LOC442465 -0.17 -0.06 -1.29 -0.46 2.77 1 2 3 4 5 -1.23 1.23 SGK2 1.43 1.26 0.03 -0.17 1.75 1 2 3 4 5 -1.23 1.23 HS.545893 -0.34 1.51 0.28 1.44 0.94 1 2 3 4 5 -1.23 1.23 HS.553354 0.27 0.89 -0.34 0.79 0.43 1 2 3 4 5 -1.23 1.23 LOC652408 0.17 1.01 -0.22 0.21 0.04 1 2 3 4 5 -1.23 1.23 LOC643401 -0.18 1.17 -0.06 -0.27 0.07 1 2 3 4 5 -1.23 1.23 HS.574587 -0.36: 1.13 -0.10 -0.08 0.67 1 2 3 4 5 -1.23 1.23 HS.541635 0.18 0.33 -0.90 0.06 1.75 1 2 3 4 5 j -1.23 1.23 LOC642629 2.00 3.33 2.10 0.17 2.98 1 2 3 4 5 -1.23 1.23 OR5K1 2.70 0.19 -1.04 -0.84 0.29 1 2 3 4 5 -1.23 1.23 HS.569052 -0.20 1.13 -0.10 0.52 0.59 1 2 3 4 5 -1.23 1.23 HS.584106 1.44 1.21 -0.02 -0.73 0.51 1 2 3 4 5 -1.23 1.23 HS.580473 0.04 0.95 -0.28 -0.36 -0.29 1 2 3 4 5 -1.23 1.23 HS.541757 1.94 1.56 0.32 -0.50 -0.58 1 2 3 4 5 -1.23 1.23 LOC732162 -0.29 0.51 -0.72 0.44 1.67 1 2 3 4 5 -1.23 1.23 LOC645730 0.29 0.31 -0.93 -0.09 -1.90 1 2 3 4 5 -1.23 1.23 HS.545556 -0.46 1.27 0.04 -0.04 0.49 1 2 3 4 5 -1.23 1.23 LOC283677 0.25 0.91 -0.33 0.16 -0.18 1 2 3 4 5 -1.23 1.23 Table 3 123 HS.564831 -0.18 0.94 -0.29 0.61 0.63 1 2 3 4 5 -1.23 1.23 HS.545122 0.86 0.75 -0.48 -0.50 -0.07 1 2 3 4 5 -1.24 1.24 HS.541150 -O.53 0.64 -0.59 -0.54 -0.44 1 2 3 4 5 -1.24 1.24 HS.574177 -0.11 0.71 -0.53 -0.20 -0.46 1 2 3 4 5 -1.24 1.24 HS.563192 -0.40 0.74 -0.50 0.82 0.67 1 2 3 4 5 -1.24 1.24 LOC649683 0.31 0.87 -0.36 -0.69 -0.79 1 2 3 4 5 -1.24 1.24 GOLGA8E 0.58 1.44 0.20 1.00 -0.01 1 2 3 4 5 -1.24 1.24 ASAH3 -0.46 1.23 0.00 0.93 -0.23 1 2 3 4 5 -1.24 1.24 HS.443685 -0.15 1.30 0.07 1.98 -0.24 1 2 3 4 5 -1.24 1.24 HS.537610 0.55 0.72 -0.52 0.59 -0.10 1 2 3 4 5 -1.24 1.24 DENND1B -0.28 0.95 -0.28 -0.12 -0.48 1 2 3 4 5 -1.24 1.24 HS.538502 -0.27 1.14 -0.10 0.31 0.08 1 2 3 4 5 -1.24 1.24 HS.543436 -0.15 1.37 0.13 0.10 0.09 1 2 3 4 5 -1.24 1.24 HS.584149 0.14 0.89 -0.35 -0.22 -0.29 1 2 3 4 5 -1.24 1.24 HS.98581 0.59 0.76 -0.48 1.26 0.06 1 2 3 4 5 -1.24 1.24 HS.281143 -0.88 0.66 -0.58 0.42 0.27 1 2 3 4 5 -1.24 1.24 OMD 0.30 1.54 0.30 0.64 1.55 1 2 3 4 5 -1.24 1.24 TMEM151A -0.01 0.67 -0.57 -0.69 -0.53 1 2 3 4 5 -1.24 1.24 HS.551097 1.59 1.18 -0.06 0.20 0.46 1 2 3 4 5 -1.24 1.24 LOC402279 0.49 1.01 -0.23 5.53 -0.38 1 2 3 4 5 -1.24 1.24 HS.566505 -0.23 1.10 -0.14 -0.43 1.12 1 2 3 4 5 -1.24 1.24 C10RF64 -0.27 0.93 -0.31 -0.24 -0.57 1 2 3 4 5 -1.24 1.24 HS.385576 -0.19 0.46 -0.78 -0.54 -0.53 1 2 3 4 5 -1.24 1.24 HS.86046 0.56 : 1.65 0.41 -1.23 -0.20 1 2 3 4 5 -1.24 1.24 LOC651128 0.56 1.81 0.57 -0.20 0.50 1 2 3 4 5 -1.24 1.24 ZNF528 0.14 ! 1.13 -0.11 -0.06 -0.01 1 2 3 4 5 -1.24 1.24 HS.543171 0.16 1.24 -0.01 -0.23 0.25 1 2 3 4 5 -1.24 1.24 CYP1A2 0.21 2.10 0.86 -0.33 0.22 1 2 3 4 5 -1.24 1.24 HS.566175 -0.02 : 0.99 -0.25 -0.23 -0.36 1 2 3 4 5 -1.24 1.24 HS.506101 1.48 0.59 -0.65 -0.48 0.83 1 2 3 4 5 -1.24 1.24 LOC644925 -0.12 0.93 -0.31 -0.19 -0.26 1 2 3 4 5 ; -1.24 1.24 HS.582510 -0.58 ' 0.14 -1.10 -0.58 -0.92 1 2 3 4 5 -1.24 1.24 HS.532285 0.65 1.02 -0.23 0.78 -0.28 1 2 3 4 5 -1.24 1.24 A N 0.78 2.97 1.72 1.27 0.32 1 2 3 4 5 -1.24 1.24 HS.160228 1.47 0.11 -1.13 0.14 1.21 1 2 3 4 5 -1.24 1.24 HS.577306 0.42 0.97 -0.28 1.79 0.32 1 2 3 4 5 -1.24 1.24 HILSI -0.29 1.20 -0.05 -0.21 -0.05 1 2 3 4 5 -1.24 1.24 LOC642185 -0.04 1.93 0.69 0.14 0.47 1 2 3 4 5 -1.24 1.24 LOC650118 1.05 1.73 0.48 0.97 0.51 1 2 3 4 5 -1.25 1.25 HS.573084 1.65 0.73 -0.52 -0.46 -0.04 1 2 3 4 5 -1.25 1.25 HS.565753 -0.15 1.13 -0.11 -0.13 0.30 1 2 3 4 5 -1.25 1.25 FIGLA 0.24 1.52 0.28 -0.23 -0.14 1 2 3 4 5 -1.25 1.25 CRYBA1 1.09 1.04 -0.20 0.05 -0.62 1 2 3 4 5 -1.25 1.25 FXYD7 -0.08 1.22 -0.03 -0.05 -0.19 1 2 3 4 5 -1.25 1.25 HS.128227 -0.77 1.38 0.13 3.25 4.72 1 2 3 4 5 -1.25 1.25 HS.563450 -0.56 0.72 -0.52 -0.74 -0.08 1 2 3 4 5 -1.25 1.25 HS.573310 -0.33 0.85 -0.39 -0.04 -0.16 1 2 3 4 5 -1.25 1.25 USP50 -1.43 -0.80 -2.04 3.19 -1.31 1 2 3 4 5 -1.25 1.25 LOC286478 -0.23 1.41 0.16 -0.24 -0.14 1 2 3 4 5 -1.25 1.25 Table 3 124 HS.550963 -0.46 0.48 -0.77 -0.40 0.37 1 2 3 4 5 -1.25 1.25 LOC260339 0.12 2.13 0.89 -0.16 -0.14 1 2 3 4 5 -1.25 1.25 SHANK2 0.23 0.92 -0.33 1.80 -0.67 1 2 3 4 5 -1.25 1.25 LOC642650 -0.05 0.82 -0.43 -0.75 -0.56 1 2 3 4 5 -1.25 1.25 LOC142937 0.19 0.90 -0.34 -0.12 0.33 1 2 3 4 5 -1.25 1.25 HS.554593 0.08 0.76 -0.49 0.67 0.08 1 2 3 4 5 -1.25 1.25 HS.567106 0.42 0.78 -0.47 0.83 -0.17 1 2 3 4 5 -1.25 1.25 RASGEF1C -0.41 0.34 -0.91 1.34 -0.71 1 2 3 4 5 -1.25 1.25 PCDHA3 -0.06 2.73 1.48 -2.15 0.86 1 2 3 4 5 -1.25 1.25 MS4A10 1.02 0.99 -0.26 2.01 3.36 1 2 3 4 5 -1.25 1.25 LOC653154 -0.08 1.19 -0.06 -0.02 0.44 1 2 3 4 5 -1.25 1.25 HS.473802 1.03 0.59 -0.66 -0.50 -0.17 1 2 3 4 5 -1.25 1.25 LOC644345 -0.08 1.06 -0.19 0.92 0.12 1 2 3 4 5 -1.25 1.25 LOC391609 2.50 0.52 -0.73 0.48 -0.48 1 2 3 4 5 -1.25 1.25 HS.566104 0.05 2.52 1.27 -1.21 1.09 1 2 3 4 5 -1.25 1.25 HS.546041 -0.41 0.72 -0.53 0.28 1.20 1 2 3 4 5 -1.25 1.25 FU25758 0.10 2.01 0.76 0.14 0.47 1 2 3 4 5 -1.25 1.25 HS.543619 0.74 1.10 -0.16 0.54 0.59 1 2 3 4 5 -1.25 1.25 HS.564556 0.03 1.16 -0.09 1.21 -0.53 1 2 3 4 5 -1.25 1.25 HS.527426 0.03 0.61 -0.64 -0.25 -0.45 1 2 3 4 5 -1.25 1.25 PC0LCE2 1.88 1.03 -0.22 -0.25 0.25 1 2 3 4 5 -1.25 1.25 HS.537753 -0.37 0.87 -0.38 0.25 -0.33 1 2 3 4 5 -1.25 1.25 HS.566494 -0.84 0.90 -0.35 -0.31 -0.58 1 2 3 4 5 -1.25 1.25 HS.543811 -0.35 0.62 -0.63 1.56 2.34 1 2 3 4 5 -1.25 1.25 HS.131114 0.52 1.69 0.44 -0.77 2.50 1 2 3 4 5 -1.25 1.25 HS.576500 -0.62 1.52 0.26 1.69 -0.06 1 2 3 4 5 -1.25 1.25 BRUN0L5 -0.16 1.31 0.05 -0.03 -0.02 1 2 3 4 5 -1.26 1.26 HS.573102 -0.19 1.09 -0.16 0.14 -0.16 1 2 3 4 5 -1.26 1.26 HS.556885 1.29 1.58 0.32 0.41 0.21 1 2 3 4 5 -1.26 1.26 LOC651131 1.36 1.34 0.09 -0.17 0.11 1 2 3 4 5 -1.26 1.26 TUB -0.42 0.74 -0.52 0.61 -0.39 1 2 3 4 5 -1.26 1.26 LOC642188 -0.39 0.77 -0.49 0.24 0.23 1 2 3 4 5 -1.26 1.26 LOC652255 -0.63 1.15 -0.10 0.80 0.90 1 2 3 4 5 -1.26 1.26 C8B 0.14 0.65 -0.60 3.28 -0.26 1 2 3 4 5 -1.26 1.26 HS.562272 -0.76 1.05 -0.21 0.65 -0.33 1 2 3 4 5 -1.26 1.26 HS.386527 -0.35 1.08 -0.18 1.21 0.35 1 2 3 4 5 -1.26 1.26 HS.539703 0.00 1.20 -0.06 -0.07 0.02 1 2 3 4 5 -1.26 1.26 LOC643240 0.01 1.16 -0.10 0.25 0.60 1 2 3 4 5 -1.26 1.26 CCKAR -0.42 0.76 -0.49 -0.33 2.32 1 2 3 4 5 -1.26 1.26 LOC648657 -0.27 1.02 -0.24 -0.28 -0.25 1 2 3 4 5 -1.26 1.26 DGAT2L3 -0.57 0.85 -0.40 -0.39 -0.62 1 2 3 4 5 -1.26 1.26 LOC440956 -0.17 1.20 -0.06 0.13 -0.54 1 2 3 4 5 -1.26 1.26 HS.508885 0.06 1.18 -0.08 0.07 -0.06 1 2 3 4 5 -1.26 1.26 HS.540167 -0.92 1.07 -0.19 1.31 1.17 1 2 3 4 5 -1.26 1.26 HS.131413 0.06 1.44 0.18 0.14 0.58 1 2 3 4 5 -1.26 1.26 SCN8A 1.30 1.01 -0.25 -0.55 2.34 1 2 3 4 5 -1.26 1.26 LECT2 0.56 0.36 -0.90 0.96 0.16 1 2 3 4 5 -1.26 1.26 HS.537750 0.67 0.95 -0.31 0.54 0.28 1 2 3 4 5 -1.26 1.26 ST70T2 0.16 1.22 -0.04 5.04 -0.34 1 2 3 4 5 -1.26 1.26 Table 3 125 HS.544670 0.44 1.39 0.13 -0.11 1.06 1 2 3 4 5 -1.26 1.26 TGFB2 2.42 0.63 -0.63 0.26 0.20 1 2 3 4 5 -1.26 1.26 HS.443281 -0.09 1.13 -0.13 -0.04 -0.19 1 2 3 4 5 -1.26 1.26 HS.496897 0.83 1.53 0.27 -0.59 -1.06 1 2 3 4 5 -1.26 1.26 HS.444158 0.43 1.13 -0.14 0.49 -0.18 1 2 3 4 5 -1.26 1.26 HS.148450 0.20 0.88 -0.38 1.12 2.45 1 2 3 4 5 -1.26 1.26 LOC391771 0.58 1.03 -0.24 -0.41 -0.64 1 2 3 4 5 -1.26 1.26 HS.559866 1.22 1.52 0.25 0.64 0.33 1 2 3 4 5 -1.27 1.27 HS.583015 -0.29 1.24 -0.03 -0.14 0.75 1 2 3 4 5 -1.27 1.27 HS.120009 1.83 1.02 -0.25 0.50 0.02 1 2 3 4 5 -1.27 1.27 FA2H -0.86 1.28 0.01 3.14 -0.80 1 2 3 4 5 -1.27 1.27 HS.195725 0.10 1.25 -0.01 -0.13 -0.07 1 2 3 4 5 -1.27 1.27 OR52I1 -0.47 0.69 -0.58 -1.02 -0.73 1 2 3 4 5 -1.27 1.27 HS.578243 1.00 -0.14 -1.41 3.38 3.30 1 2 3 4 5 -1.27 1.27 OR10H1 4.06 0.47 -0.79 0.35 -1.78 1 2 3 4 5 -1.27 1.27 HS.552263 0.74 0.89 -0.37 1.12 0.28 1 2 3 4 5 -1.27 1.27 UGT3A1 -0.41 0.76 -0.51 -0.30 0.90 1 2 3 4 5 -1.27 1.27 HS.581431 1.40 0.88 -0.39 -0.46 4.68 1 2 3 4 5 -1.27 1.27 HS.555717 -0.71 0.20 -1.07 0.80 0.79 1 2 3 4 5 -1.27 1.27 HS.146759 -0.17 0.93 -0.34 0.23 -0.14 1 2 3 4 5 -1.27 1.27 HS.573681 -0.48 1.00 -0.27 0.63 -0.01 1 2 3 4 5 -1.27 1.27 LOC647215 -0.85 2.09 0.82 1.01 -0.70 1 2 3 4 5 -1.27 1.27 TPRG1 -0.09 0.70 -0.56 -0.28 0.07 1 2 3 4 5 -1.27 1.27 LOC649486 0.31 2.31 1.04 -0.36 -0.42 1 2 3 4 5 -1.27 1.27 LOC642480 0.74 0.70 -0.57 -0.55 0.37 1 2 3 4 5 -1.27 1.27 HS.564822 -0.27 1.31 0.04 0.98 -0.33 1 2 3 4 5 -1.27 1.27 HS.562302 -0.96 2.51 1.23 -0.37 0.43 1 2 3 4 5 -1.27 1.27 HS.559884 -0.16 1.03 -0.24 -0.22 -0.03 1 2 3 4 5 -1.27 1.27 HS.545986 -0.07 0.73 -0.54 -0.35 -0.12 1 2 3 4 5 -1.27 1.27 LOC652715 -0.02 1.23 -0.04 -0.82 -0.83 1 2 3 4 5 -1.27 1.27 HS.575129 1.24 0.76 -0.52 1.29 0.05 1 2 3 4 5 -1.27 1.27 LOC645330 0.19 1.31 0.04 -0.04 -0.01 1 2 3 4 5 -1.27 1.27 LOC642280 2.42 1.22 -0.05 1.89 -0.29 1 2 3 4 5 -1.27 1.27 HS.541291 2.63 0.97 -0.30 -0.63 -0.63 1 2 3 4 5 -1.27 1.27 C70RF33 -1.14 0.12 -1.15 -0.63 0.63 1 2 3 4 5 -1.27 1.27 HS.122054 -0.40 0.77 -0.50 -0.05 -0.42 1 2 3 4 5 -1.27 1.27 HS.172751 -0.49 0.87 -0.40 1.42 -0.44 1 2 3 4 5 -1.27 1.27 FU36032 0.72 1.33 0.05 0.51 0.17 1 2 3 4 5 -1.27 1.27 LOC653180 0.91 1.41 0.14 1.77 2.29 1 2 3 4 5 -1.27 1.27 HS.133191 -0.41 0.79 -0.48 2.95 0.55 1 2 3 4 5 -1.27 1.27 HS.562277 -0.18 1.16 -0.12 -0.02 0.26 1 2 3 4 5 -1.27 1.27 HS.559427 -0.33 1.10 -0.17 -1.42 2.14 1 2 3 4 5 -1.27 1.27 LOC285484 0.13 0.61 -0.66 1.25 -0.33 1 2 3 4 5 -1.27 1.27 HS.114070 0.84 0.98 -0.30 0.39 0.06 1 2 3 4 5 -1.27 1.27 HS.573947 1.10 2.64 1.36 0.52 2.79 1 2 3 4 5 -1.28 1.28 HS.563783 0.55 1.41 0.14 0.17 -0.13 1 2 3 4 5 -1.28 1.28 HS.542624 0.16 0.34 -0.94 0.10 -0.70 1 2 3 4 5 -1.28 1.28 HS.565808 -1.32 0.75 -0.52 0.46 0.37 1 2 3 4 5 -1.28 1.28 HS.584250 1.24 0.74 -0.54 -0.52 0.06 1 2 3 4 5 -1.28 1.28 Table 3 126 LOC652141 1.53 0.44 -0.84 0.00 0.30 1 2 3 4 5 -1.28 1.28 LOC649823 1.23 2.87 1.59 0.16 0.16 1 2 3 4 5 -1.28 1.28 HS.577971 -o.oi ; 0.97 -0.31 -0.21 -0.40 1 2 3 4 5 : -1.28 1.28 HS.580757 0.33; 0.47 -0.81 -0.35 0.54 1 2 3 4 5 -1.28 1.28 HS.566138 2.09 1.02 -0.25 1.32 0.01 1 2 3 4 5 -1.28 1.28 HS.444059 -0.15 1.06 -0.22 0.27 0.77 1 2 3 4 5 -1.28 1.28 HS.388217 1.79 3.10 1.82 0.92 -0.83 1 2 3 4 5 -1.28 1.28 HS.541684 1.26 2.28 1.00 2.02 -0.01 1 2 3 4 5 -1.28 1.28 HS.128620 -ass; 0.57 -0.71 -0.90 -0.80 1 2 3 4 5 -1.28 1.28 SPANXE -0.21 1.08 -0.20 0.75 0.93 1 2 3 4 5 -1.28 1.28 DEPDC1 -0.08 1.16 -0.12 2.84 -0.90 1 2 3 4 5 -1.28 1.28 LOC642497 -1.03 1.08 -0.20 0.61 0.36 1 2 3 4 5 -1.28 1.28 SSX4B 0.97 0.99 -0.29 0.28 0.47 1 2 3 4 5 -1.28 1.28 SHISA3 -0.58 1.35 0.07 -0.17 0.47 1 2 3 4 5 -1.28 1.28 C90RF18 -0.69 1.11 -0.17 4.59 1.59 1 2 3 4 5 -1.28 1.28 HS.132649 -0.04 0.94 -0.34 -0.44 -0.29 1 2 3 4 5 -1.28 1.28 HS.564724 -0.03 6.01 4.72 1.54 -0.77 1 2 3 4 5 -1.28 1.28 HS.164131 -1.11 0.77 -0.51 0.23 -1.45 1 2 3 4 5 -1.28 1.28 SST -0.72 4.24 2.96 -0.02 -0.07 1 2 3 4 5 -1.28 1.28 HS.551788 -0.46 1.11 -0.17 -0.03 -0.41 1 2 3 4 5 -1.28 1.28 HS.119993 1.14 2.15 0.87 0.61 -0.66 1 2 3 4 5 -1.28 1.28 HS.564543 0.37 1.36 0.08 1.35 -0.38 1 2 3 4 5 -1.28 1.28 LOC642832 -0.11 0.63 -0.66 -0.81 2.28 1 2 3 4 5 -1.28 1.28 HS.544760 0.01 0.96 -0.32 0.44 0.23 1 2 3 4 5 -1.28 1.28 HS.545430 0.96 0.82 -0.46 -0.04 0.03 1 2 3 4 5 -1.29 1.29 HS.126964 -0.06 1.25 -0.04 2.70 -0.24 1 2 3 4 5 -1.29 1.29 OR52L1 -0.88; 0.12 -1.16 -0.73 -0.13 1 2 3 4 5 -1.29 1.29 ST70T4 -0.47 2.07 0.79 2.40 2.43 1 2 3 4 5 -1.29 1.29 NXF5 -0.35 0.56 -0.73 -0.40 0.20 1 2 3 4 5 -1.29 1.29 HS.543744 0.00 3.00 1.71 -0.41 1.57 1 2 3 4 5 -1.29 1.29 LOC642374 -0.16; 1.18 -0.11 -0.03 -0.26 1 2 3 4 5 -1.29 1.29 LOC643702 0.03 1.47 0.18 0.35 -0.48 1 2 3 4 5 -1.29 1.29 KLK13 1.20 0.63 -0.65 -0.20 1.28 1 2 3 4 5 -1.29 1.29 LOC649749 -0.12 2.15 0.86 0.28 0.94 1 2 3 4 5 -1.29 1.29 LOC644783 3.23 0.88 -0.40 -0.24 1.18 1 2 3 4 5 -1.29 1.29 HS.539690 0.37 1.26 -0.03 -0.06 0.07 1 2 3 4 5 -1.29 1.29 LOC648403 -0.09 1.04 -0.25 0.07 -0.10 1 2 3 4 5 -1.29 1.29 HS.340743 -0.34 0.76 -0.53 0.81 -0.51 1 2 3 4 5 -1.29 1.29 HS.566310 -0.16, 0.92 -0.37 0.48 -0.18 1 2 3 4 5 -1.29 1.29 HS.523675 0.87 0.81 -0.48 -0.12 -0.11 1 2 3 4 5 -1.29 1.29 USP43 -0.40 1.01 -0.28 -0.38 0.20 1 2 3 4 5 -1.29 1.29 HS.481491 -0.31 1.11 -0.18 0.25 -0.25 1 2 3 4 5 -1.29 1.29 HS.554410 -0.33 1.27 -0.02 1.41 1.67 1 2 3 4 5 -1.29 1.29 HS.538640 -0.09 1.07 -0.22 0.04 -0.04 1 2 3 4 5 -1.29 1.29 ZNF639 0.18 2.11 0.82 -0.03 -0.35 1 2 3 4 5 -1.29 1.29 HS.581341 0.69 1.00 -0.30 -0.38 -0.52 1 2 3 4 5 -1.29 1.29 LOC646193 -0.07 0.08 -1.22 1.62 0.47 1 2 3 4 5 -1.29 1.29 GARNL3 -0.66 0.46 -0.84 -0.28 -0.52 1 2 3 4 5 -1.29 1.29 HS.297353 -0.03 1.45 0.16 -0.23 0.44 1 2 3 4 5 -1.29 1.29 Table 3 127 HS.542037 0.64 1.22 -0.08 -0.35 -0.32 1 2 3 4 5 -1.29 1.29 HS.495947 -0.81 -0.37 -1.67 1.24 -0.89 1 2 3 4 5 -1.29 1.29 LOC648585 0.44 1.15 -0.15 0.04 -0.17 1 2 3 4 5 -1.29 1.29 LOC440896 -0.62 0.32 -0.97 -0.49 1.90 1 2 3 4 5 -1.29 1.29 LOC646471 -1.18 0.71 -0.58 0.19 -0.41 1 2 3 4 5 -1.29 1.29 LOC642621 0.62 1.10 -0.19 1.62 -0.08 1 2 3 4 5 -1.29 1.29 HS.572261 1.91 0.04 -1.26 1.35 2.71 1 2 3 4 5 -1.29 1.29 HS.544246 0.55 0.84 -0.46 0.57 -0.57 1 2 3 4 5 -1.29 1.29 HS.573805 1.25 2.44 1.14 -0.65 -0.14 1 2 3 4 5 -1.29 1.29 HS.210308 -0.11 1.85 0.56 0.33 0.19 1 2 3 4 5 -1.29 1.29 HS.577295 -0.18 1.48 0.18 -0.11 -0.20 1 2 3 4 5 -1.29 1.29 LOC653155 0.08 1.33 0.04 0.44 0.36 1 2 3 4 5 -1.30 1.30 LOC645144 1.95 1.06 -0.23 -0.35 0.08 1 2 3 4 5 -1.30 1.30 LOC642014 1.88 2.17 0.88 2.87 -0.41 1 2 3 4 5 -1.30 1.30 LOC389852 -0.44 0.95 -0.34 -0.36 0.08 1 2 3 4 5 -1.30 1.30 HS.49112 3.87 0.55 -0.74 -0.73 -0.99 1 2 3 4 5 -1.30 1.30 HS.31941 -0.36 3.08 1.78 3.26 -0.54 1 2 3 4 5 -1.30 1.30 HS.565130 -0.23 1.65 0.35 -0.09 0.05 1 2 3 4 5 -1.30 1.30 IRGQ 0.95 1.31 0.02 1.61 0.93 1 2 3 4 5 -1.30 1.30 HS.565434 0.32 1.25 -0.05 0.13 0.11 1 2 3 4 5 -1.30 1.30 LOC285941 -0.20 1.07 -0.23 0.02 0.25 1 2 3 4 5 -1.30 1.30 LOC644973 -0.24 1.07 -0.23 1.75 -0.43 1 2 3 4 5 -1.30 1.30 HS.572747 -0.45 1.68 0.38 1.15 0.03 1 2 3 4 5 -1.30 1.30 HS.572224 0.10 1.04 -0.26 0.80 1.21 1 2 3 4 5 -1.30 1.30 HS.387982 -0.20 1.00 -0.31 0.01 -0.27 1 2 3 4 5 -1.30 1.30 DEFB129 3.46 2.31 1.01 -1.46 4.28 1 2 3 4 5 -1.30 1.30 FAM44A -0.18 0.96 -0.34 -0.32 -0.94 1 2 3 4 5 -1.30 1.30 SLC13A5 -0.70 0.46 -0.84 -0.07 -0.75 1 2 3 4 5 -1.30 1.30 SLC5A11 0.46 0.62 -0.68 -0.45 -0.32 1 2 3 4 5 -1.30 1.30 HS.580643 -1.18 -0.26 -1.57 2.17 -0.53 1 2 3 4 5 -1.30 1.30 HS.584269 -0.38 1.05 -0.25 5.24 -0.70 1 2 3 4 5 -1.30 1.30 HS.566422 3.03 1.09 -0.22 0.40 0.73 1 2 3 4 5 -1.31 1.31 LOC649965 -0.58 0.65 -0.65 0.26 -0.87 1 2 3 4 5 -1.31 1.31 CHX10 -0.15 0.88 -0.42 -0.10 -0.24 1 2 3 4 5 -1.31 1.31 HS.544735 -0.53 1.22 -0.08 0.11 -0.44 1 2 3 4 5 -1.31 1.31 HS.559898 0.84 0.82 -0.49 0.00 1.73 1 2 3 4 5 -1.31 1.31 NKX2-5 1.54 0.58 -0.72 2.34 1.27 1 2 3 4 5 -1.31 1.31 HS.543193 1.56 0.16 -1.15 -0.23 0.39 1 2 3 4 5 -1.31 1.31 SYT2 -0.17 -0.47 -1.77 0.70 2.98 1 2 3 4 5 -1.31 1.31 C40RF39 0.43 1.24 -0.07 0.32 -0.13 1 2 3 4 5 -1.31 1.31 MYH15 -0.95 0.69 -0.62 -1.08 0.24 1 2 3 4 5 -1.31 1.31 HS.158785 0.15 1.05 -0.25 -0.37 0.93 1 2 3 4 5 -1.31 1.31 HS.523975 0.85 0.09 -1.22 1.30 0.50 1 2 3 4 5 -1.31 1.31 LOC387804 0.51 0.72 -0.59 -0.29 -0.45 1 2 3 4 5 -1.31 1.31 HS.185553 -0.56 0.50 -0.81 0.44 -0.15 1 2 3 4 5 -1.31 1.31 HS.232417 -0.17 1.40 0.09 -0.21 0.10 1 2 3 4 5 -1.31 1.31 PTCHD2 4.60 0.78 -0.52 -1.05 -0.46 1 2 3 4 5 -1.31 1.31 HS.569340 -0.12 1.23 -0.08 0.73 -0.06 1 2 3 4 5 -1.31 1.31 LOC650744 -0.12 0.98 -0.33 -0.33 -0.55 1 2 3 4 5 -1.31 1.31 Table 3 128 HS.538864 0.24 1.26 -0.05 -0.54 -0.87 1 2 3 4 5 -1.31 1.31 LOC391165 -0.22 0.72 -0.59 2.69 -0.15 1 2 3 4 5 -1.31 1.31 ST8SIA6 1.00 1.24 -0.07 0.35 -0.05 1 2 3 4 5 -1.31 1.31 HS.540643 7.14 0.28 -1.03 3.90 0.02 1 2 3 4 5 -1.31 1.31 HS.525758 6.40 1.60 0.29 -0.30 3.34 1 2 3 4 5 -1.31 1.31 LCN6 -0.92 1.00 -0.31 -0.45 4.16 1 2 3 4 5 -1.31 1.31 HS.563829 -0.16 2.78 1.47 0.64 -1.41 1 2 3 4 5 -1.31 1.31 HS.565628 0.78; 1.26 -0.05 -0.24 -0.06 1 2 3 4 5 -1.31 1.31 LOC650965 -0.14 0.70 -0.62 -0.52 -0.70 1 2 3 4 5 -1.31 1.31 HS.386597 -0.49 0.57 -0.75 0.65 -0.22 1 2 3 4 5 -1.31 1.31 HS.48787 1.04 0.19 -1.13 1.68 0.97 1 2 3 4 5 -1.31 1.31 TFAMPl 3.81 0.89 -0.42 0.37 1.23 1 2 3 4 5 -1.32 1.32 FAM75A2 1.88 1.12 -0.19 2.52 0.36 1 2 3 4 5 -1.32 1.32 LOC653746 -0.61 0.45 -0.86 0.74 0.18 1 2 3 4 5 -1.32 1.32 LOC643060 -0.31 0.26 -1.05 -0.47 -0.40 1 2 3 4 5 -1.32 1.32 PAL1 -0.44 2.98 1.66 1.14 1.90 1 2 3 4 5 -1.32 1.32 LOC645325 1.32 0.82 -0.50 1.41 0.50 1 2 3 4 5 -1.32 1.32 TTTY6 -0.63 0.86 -0.46 0.19 0.43 1 2 3 4 5 -1.32 1.32 FBF1 0.20 0.85 -0.47 0.38 -0.16 1 2 3 4 5 -1.32 1.32 LOC440792 -0.72 0.12 -1.20 -0.81 0.33 1 2 3 4 5 -1.32 1.32 HS.544719 0.45 1.25 -0.07 0.02 -0.15 1 2 3 4 5 -1.32 1.32 HS.565142 0.89 0.65 -0.67 -1.24 -0.29 1 2 3 4 5 -1.32 1.32 HS.577738 -0.09: 1.89 0.57 1.05 0.50 1 2 3 4 5 -1.32 1.32 NEUR0D4 2.03 1.45 0.13 0.53 0.21 1 2 3 4 5 -1.32 1.32 HS.543703 0.22 1.42 0.10 -0.23 -0.15 1 2 3 4 5 -1.32 1.32 APOE -0.59 0.68 -0.64 0.10 0.04 1 2 3 4 5 -1.32 1.32 LOC729238 -0.47 0.82 -0.50 -0.13 0.85 1 2 3 4 5 -1.32 1.32 LOC648111 0.83 1.31 -0.01 0.21 1.03 1 2 3 4 5 -1.32 1.32 MY05B 0.66 0.81 -0.51 -0.39 0.73 1 2 3 4 5 -1.32 1.32 HS.577522 1.56 0.16 -1.17 0.26 -0.28 1 2 3 4 5 -1.32 1.32 HS.538039 -0.28, 0.41 -0.92 -1.06 0.10 1 2 3 4 5 -1.32 1.32 HS.571915 0.53 1.10 -0.22 -0.08 1.66 1 2 3 4 5 -1.32 1.32 ADAM30 1.35 1.01 -0.31 -0.44 0.11 1 2 3 4 5 -1.33 1.33 HS.554269 1.33 0.19 -1.13 -0.73 0.76 1 2 3 4 5 -1.33 1.33 OTC -0.59 0.92 -0.41 -1.09 -1.24 1 2 3 4 5 -1.33 1.33 HS.541002 0.06 0.96 -0.36 0.75 0.82 1 2 3 4 5 -1.33 1.33 FU21511 -0.08 0.75 -0.57 -0.19 0.65 1 2 3 4 5 -1.33 1.33 HS.545606 -0.80 -0.35 -1.68 -0.60 -0.91 1 2 3 4 5 -1.33 1.33 HS.570950 0.55 2.10 0.78 0.57 3.49 1 2 3 4 5 -1.33 1.33 HS.563846 -0.33 0.69 -0.64 0.89 0.15 1 2 3 4 5 -1.33 1.33 HS.551432 -0.22 2.23 0.91 -0.19 0.12 1 2 3 4 5 -1.33 1.33 KITLG 0.22 0.57 -0.76 0.96 -1.00 1 2 3 4 5 -1.33 1.33 HS.554213 -0.33 0.83 -0.49 -0.12 -0.14 1 2 3 4 5 -1.33 1.33 HS.563869 0.88 1.20 -0.13 2.35 2.73 1 2 3 4 5 -1.33 1.33 DOCK6 -0.45 1.23 -0.09 0.68 0.46 1 2 3 4 5 -1.33 1.33 PCDHB15 0.11 1.30 -0.03 5.19 -2.10 1 2 3 4 5 -1.33 1.33 HS.541774 0.06 0.77 -0.56 -0.52 -0.57 1 2 3 4 5 -1.33 1.33 HS.575681 0.01 0.92 -0.41 -0.24 -0.40 1 2 3 4 5 -1.33 1.33 HS.583002 -0.37 1.26 -0.07 -0.57 -0.48 1 2 3 4 5 -1.33 1.33 Table 3 129 HS.566819 -0.35 0.84 -0.49 -0.27 0.08 1 2 3 4 5 -1.33 1.33 PCDHGA3 1.95 1.44 0.11 -0.39 -0.13 1 2 3 4 5 -1.33 1.33 HS.547245 -0.25 1.37 0.04 -0.24 -0.09 1 2 3 4 5 -1.33 1.33 HS.437452 -0.63 0.41 -0.92 3.02 0.46 1 2 3 4 5 -1.33 1.33 HS.550888 -0.23 1.47 0.14 0.75 0.35 1 2 3 4 5 -1.33 1.33 HS.555421 -0.08 1.90 0.57 -0.45 2.07 1 2 3 4 5 -1.33 1.33 HS.560397 -0.44; 0.68 -0.65 -0.37 -0.04 1 2 3 4 5 -1.33 1.33 HS.132568 1.01 0.72 -0.61 -0.23 1.96 1 2 3 4 5 -1.33 1.33 HS.543977 0.08 1.66 0.33 1.05 -0.46 1 2 3 4 5 -1.33 1.33 C210RF49 -0.18 0.83 -0.50 -0.01 -0.41 1 2 3 4 5 -1.33 1.33 PRKD1 0.64 0.10 -1.23 0.72 3.29 1 2 3 4 5 -1.33 1.33 LOC642164 0.22 0.46 -0.87 1.37 0.22 1 2 3 4 5 -1.33 1.33 HS.545867 1.68 1.46 0.13 -0.07 0.46 1 2 3 4 5 -1.33 1.33 HS.561891 0.38 0.70 -0.63 0.39 -0.49 1 2 3 4 5 -1.33 1.33 LOC389394 -0.55 1.57 0.23 2.90 -0.42 1 2 3 4 5 -1.33 1.33 LOC644188 0.20 0.72 -0.62 -0.16 -0.28 1 2 3 4 5 -1.33 1.33 LOC652801 1.53 1.53 0.20 0.56 2.45 1 2 3 4 5 -1.33 1.33 LOC647888 0.88 0.67 -0.66 0.52 -0.13 1 2 3 4 5 -1.33 1.33 HS.569508 0.21 1.56 0.22 -0.18 0.12 1 2 3 4 5 -1.33 1.33 LOC645444 2.84 1.50 0.16 0.10 1.11 1 2 3 4 5 -1.33 1.33 PXDNL -0.53 0.93 -0.41 -0.55 1.42 1 2 3 4 5 -1.33 1.33 HS.442246 1.99 1.76 0.42 -0.30 -0.03 1 2 3 4 5 -1.34 1.34 LOC646268 4.84 0.89 -0.44 0.54 1.68 1 2 3 4 5 -1.34 1.34 CCDC87 -0.04 0.95 -0.39 -0.76 0.12 1 2 3 4 5 -1.34 1.34 LOC644229 0.20 1.09 -0.25 -0.19 -0.43 1 2 3 4 5 -1.34 1.34 HS.435020 -0.35 0.92 -0.42 0.03 0.69 1 2 3 4 5 -1.34 1.34 HS.122441 0.23 1.93 0.59 0.36 1.29 1 2 3 4 5 -1.34 1.34 HS.543985 -0.36: 0.83 -0.51 -0.17 1.32 1 2 3 4 5 -1.34 1.34 HS.583853 6.41 0.92 -0.42 -0.35 -0.20 1 2 3 4 5 -1.34 1.34 DDR2 -0.06 1.05 -0.29 0.82 -0.19 1 2 3 4 5 -1.34 1.34 HS.544973 -0.59 1.11 -0.23 -0.20 0.33 1 2 3 4 5 -1.34 1.34 LOC649616 -0.05 1.37 0.03 0.29 -0.26 1 2 3 4 5 -1.34 1.34 HS.125563 -0.60 0.39 -0.95 7.56 -1.06 1 2 3 4 5 -1.34 1.34 CALCA 0.06 0.48 -0.86 -0.60 -0.84 1 2 3 4 5 -1.34 1.34 HS.389506 0.01 0.66 -0.68 3.08 1.24 1 2 3 4 5 -1.34 1.34 HS.564371 0.23 0.99 -0.35 -0.13 -0.03 1 2 3 4 5 -1.34 1.34 LOC647333 1.66 0.58 -0.76 -0.89 -0.89 1 2 3 4 5 -1.34 1.34 HS.549963 1.52 0.71 -0.64 1.38 0.35 1 2 3 4 5 -1.34 1.34 HS.547703 1.49 1.49 0.15 0.31 -0.03 1 2 3 4 5 -1.34 1.34 HS.148810 1.14 0.79 -0.55 0.09 0.67 1 2 3 4 5 -1.34 1.34 HS.500965 -0.23 1.96 0.62 0.81 0.25 1 2 3 4 5 -1.34 1.34 HS.577965 0.02 0.96 -0.39 -0.19 -0.28 1 2 3 4 5 -1.34 1.34 HS.442253 -0.19 1.21 -0.14 0.73 -0.28 1 2 3 4 5 -1.34 1.34 HS.571292 -0.16 1.14 -0.20 -0.03 0.00 1 2 3 4 5 -1.34 1.34 HS.543478 -0.49 1.45 0.10 -0.30 0.04 1 2 3 4 5 -1.34 1.34 LOC146325 -0.34 0.52 -0.82 -0.25 -0.75 1 2 3 4 5 -1.34 1.34 LOC648680 4.94 3.15 1.80 -0.56 -0.34 1 2 3 4 5 -1.34 1.34 HS.521205 -0.36 1.40 0.05 1.54 0.22 1 2 3 4 5 -1.34 1.34 HS.333694 -0.07 0.74 -0.60 -0.53 -0.29 1 2 3 4 5 -1.34 1.34 Table 3 130 HS.543659 1.06 1.46 0.12 0.19 0.21 1 2 3 4 5 -1.34 1.34 HS.521250 -0.51 0.07 -1.27 0.30 -1.53 1 2 3 4 5 -1.35 1.35 HS.510096 0.72 0.71 -0.64 0.24 2.98 1 2 3 4 5 -1.35 1.35 HS.563889 1.76 1.17 -0.18 0.02 -0.29 1 2 3 4 5 -1.35 1.35 HS.406568 -0.92 1.19 -0.16 -1.20 -0.46 1 2 3 4 5 -1.35 1.35 ZNF452 4.11 1.12 -0.22 0.46 0.52 1 2 3 4 5 -1.35 1.35 HS.556777 0.27 1.31 -0.03 0.13 0.26 1 2 3 4 5 -1.35 1.35 HS.171274 0.33 1.18 -0.17 0.13 0.98 1 2 3 4 5 -1.35 1.35 HS.542909 0.55 1.42 0.07 1.14 1.60 1 2 3 4 5 -1.35 1.35 HS.528228 -0.40 1.01 -0.34 -0.58 0.08 1 2 3 4 5 -1.35 1.35 FU20464 -0.44 0.56 -0.79 0.38 0.16 1 2 3 4 5 -1.35 1.35 HS.404330 1.52 1.71 0.35 -1.00 -0.12 1 2 3 4 5 -1.35 1.35 LOC644838 0.62 0.73 -0.62 0.97 0.91 1 2 3 4 5 -1.35 1.35 HS.98724 0.13 1.85 0.50 0.63 -0.56 1 2 3 4 5 -1.35 1.35 CNTNAP4 0.77 1.35 0.00 -0.24 -0.15 1 2 3 4 5 -1.35 1.35 HS.568674 0.68 1.18 -0.17 -0.24 0.31 1 2 3 4 5 -1.35 1.35 HS.569281 -0.10 1.01 -0.34 -0.13 3.12 1 2 3 4 5 -1.35 1.35 HS.578805 0.65 3.31 1.96 -0.38 -0.36 1 2 3 4 5 -1.35 1.35 HS.544405 -0.85 0.36 -0.99 0.12 -0.66 1 2 3 4 5 -1.35 1.35 HS.540910 0.22; 1.12 -0.23 -0.09 0.13 1 2 3 4 5 -1.35 1.35 HS.550236 0.01 0.68 -0.67 0.85 -0.49 1 2 3 4 5 -1.35 1.35 LOC647107 4.95 1.03 -0.32 -0.35 -0.43 1 2 3 4 5 -1.35 1.35 HS.223741 -0.27 1.20 -0.16 0.18 -0.12 1 2 3 4 5 -1.35 1.35 RNF150 0.32 1.19 -0.16 0.30 0.24 1 2 3 4 5 -1.35 1.35 BPY2B -0.36 1.71 0.36 0.54 0.17 1 2 3 4 5 -1.36 1.36 LOC649404 -0.60 0.83 -0.52 -0.63 -0.30 1 2 3 4 5 -1.36 1.36 HS.569297 0.41 1.14 -0.22 0.17 -0.15 1 2 3 4 5 -1.36 1.36 HS.574067 -0.47: 1.04 -0.31 -0.24 -0.42 1 2 3 4 5 -1.36 1.36 ZDHHC19 0.73 1.79 0.43 0.03 0.01 1 2 3 4 5 -1.36 1.36 RNASE12 0.49! 1.18 -0.18 -0.79 0.32 1 2 3 4 5 -1.36 1.36 POU5F1P1 0.36; 0.98 -0.38 -0.17 -0.18 1 2 3 4 5 -1.36 1.36 HS.565468 0.24 0.82 -0.54 0.58 0.29 1 2 3 4 5 -1.36 1.36 HS.549722 -0.41 1.32 -0.04 3.16 -0.39 1 2 3 4 5 -1.36 1.36 PRDM16 -1.25 2.45 1.09 0.46 -0.29 1 2 3 4 5 -1.36 1.36 HS.543189 -0.72 0.68 -0.69 3.55 0.16 1 2 3 4 5 -1.36 1.36 HS.564991 -0.60 0.61 -0.76 0.60 -0.35 1 2 3 4 5 -1.36 1.36 LOC649246 0.24 1.50 0.13 0.21 -0.24 1 2 3 4 5 -1.36 1.36 KIAA1345 0.06 1.27 -0.09 -0.62 0.52 1 2 3 4 5 -1.36 1.36 LOC643409 1.81 0.72 -0.64 -0.36 0.39 1 2 3 4 5 -1.36 1.36 HS.584687 0.60, 0.91 -0.46 0.20 -0.17 1 2 3 4 5 -1.37 1.37 HS.584662 -0.62 0.65 -0.72 -0.72 -0.40 1 2 3 4 5 -1.37 1.37 HS.576915 -0.02 1.30 -0.07 0.34 -0.03 1 2 3 4 5 -1.37 1.37 LOC643595 0.56 0.53 -0.84 0.78 -0.34 1 2 3 4 5 -1.37 1.37 NPY6R 0.14 1.30 -0.07 0.70 0.05 1 2 3 4 5 -1.37 1.37 XKR4 -0.44 -0.12 -1.49 -0.33 -0.49 1 2 3 4 5 -1.37 1.37 KLHL23 0.24 0.77 -0.60 1.09 0.79 1 2 3 4 5 -1.37 1.37 GPR110 -0.22 2.19 0.82 0.47 0.94 1 2 3 4 5 -1.37 1.37 HS.574785 -0.30 0.83 -0.54 0.14 0.21 1 2 3 4 5 -1.37 1.37 LOC643740 -0.04 1.48 0.11 0.03 0.24 1 2 3 4 5 -1.37 1.37 Table 3 131

LOC651398 -0.35 0.86 -0.51 -0.16 -0.34 1 2 3 4 5 -1.37 1.37 HS.134696 1.12 0.82 -0.56 0.87 0.53 1 2 3 4 5 -1.37 1.37 HS.441591 0.20 1.04 -0.33 0.32 -0.49 1 2 3 4 5 -1.37 1.37 HAP1 0.15 0.64 -0.73 1.00 -0.49 1 2 3 4 5 -1.37 1.37 ASPN 1.08 0.78 -0.59 0.35 -0.30 1 2 3 4 5 -1.37 1.37 HS.116199 -1.29 0.51 -0.86 2.68 1.28 1 2 3 4 5 -1.37 1.37 ST0ML3 0.02 0.93 -0.45 0.47 0.11 1 2 3 4 5 -1.37 1.37 LOC651316 1.30 1.29 -0.08 0.05 -0.13 1 2 3 4 5 -1.37 1.37 HS.536165 1.11 0.63 -0.74 -0.42 1.13 1 2 3 4 5 -1.37 1.37

HS.576088 0.60 ' 1.59 0.21 -0.10 -0.25 1 2 3 4 5 -1.37 1.37 LOC652256 -0.22 1.18 -0.19 0.04 -0.21 1 2 3 4 5 -1.37 1.37 HS.581247 0.64 1.45 0.08 -0.72 0.50 1 2 3 4 5 -1.37 1.37 ACOXL -0.69 1.34 -0.03 5.54 4.19 1 2 3 4 5 -1.37 1.37 HS.580392 0.74 1.11 -0.26 0.07 0.04 1 2 3 4 5 -1.37 1.37 LOC648149 0.28 0.82 -0.55 0.01 0.05 1 2 3 4 5 -1.38 1.38 HS.570996 -0.31 1.53 0.16 0.00 3.37 1 2 3 4 5 -1.38 1.38 LOC645459 0.45 1.60 0.22 0.02 -0.11 1 2 3 4 5 -1.38 1.38 FNDC5 -0.57 1.10 -0.27 -0.38 0.34 1 2 3 4 5 -1.38 1.38 LOC401222 0.35 1.01 -0.37 0.58 -0.34 1 2 3 4 5 -1.38 1.38 CYR61 -0.62 0.96 -0.42 -0.58 -0.24 1 2 3 4 5 -1.38 1.38 HS.540062 0.26 0.55 -0.83 1.82 0.80 1 2 3 4 5 -1.38 1.38 HS.573377 0.40 1.04 -0.34 -0.38 -0.31 1 2 3 4 5 -1.38 1.38 LOC648738 2.85 2.54 1.16 0.68 0.93 1 2 3 4 5 -1.38 1.38

MSH4 0.32 1.08 -0.29 0.73 ' 0.73 1 2 3 4 5 -1.38 1.38

LOC441108 -0.24! 1.13 -0.25 1.16 -0.18 1 2 3 4 5 -1.38 1.38 HS.582949 1.35 1.79 0.41 1.49 -0.31 1 2 3 4 5 -1.38 1.38 LYZL1 -0.31 1.04 -0.34 0.37 0.00 1 2 3 4 5 -1.38 1.38 LOC643130 0.09; 1.05 -0.33 -0.19 -0.13 1 2 3 4 5 -1.38 1.38 HS.561216 0.41 1.22 -0.16 -1.01 -0.30 1 2 3 4 5 -1.38 1.38 FU33544 -0.04 1.16 -0.22 -0.03 0.24 1 2 3 4 5 -1.38 1.38 HS.133024 -0.20 0.80 -0.58 -0.22 -0.28 1 2 3 4 5 -1.38 1.38 HS.546020 1.72 1.16 -0.22 3.21 0.16 1 2 3 4 5 -1.38 1.38 CCDC74B -0.50 0.88 -0.50 -0.37 0.32 1 2 3 4 5 -1.38 1.38 FAM9C 0.53 1.00 -0.38 -0.41 2.28 1 2 3 4 5 -1.38 1.38

OR5B2 -0.27; 1.36 -0.02 -0.09 0.78 1 2 3 4 5 -1.38 1.38 LOC652022 -0.12 1.37 -0.02 -0.30 2.28 1 2 3 4 5 -1.38 1.38 LOC651713 0.07 1.70 0.31 -0.28 -0.23 1 2 3 4 5 -1.38 1.38 HS.567059 0.10 1.17 -0.21 0.62 -0.33 1 2 3 4 5 -1.38 1.38

LOC152578 1.26; 1.26 -0.12 0.08 -0.35 1 2 3 4 5 -1.38 1.38 PCDHA9 -0.13 1.21 -0.18 -0.01 -0.25 1 2 3 4 5 -1.38 1.38 FGF12 3.00 1.22 -0.16 1.63 -0.05 1 2 3 4 5 -1.38 1.38 LOC646215 0.32 0.40 -0.98 2.35 3.72 1 2 3 4 5 -1.38 1.38 LOC654172 0.17 1.36 -0.02 0.39 0.09 1 2 3 4 5 -1.38 1.38 DEFB4 -0.45 0.60 -0.79 -0.39 1.24 1 2 3 4 5 -1.38 1.38 HS.528268 0.34 1.18 -0.20 -0.18 -0.46 1 2 3 4 5 -1.39 1.39 HS.385479 -0.63 1.33 -0.05 -0.55 -0.31 1 2 3 4 5 -1.39 1.39 OR2G3 -0.16 1.19 -0.20 0.63 -0.03 1 2 3 4 5 -1.39 1.39 FAM47A 0.54 0.73 -0.65 2.30 0.59 1 2 3 4 -1.39 1.39 HS.557559 -0.26 1.21 -0.18 -0.16 -0.27 1 2 3 4 -1.39 1.39 Table 3 132

LOC648751 -0.38 1.15 -0.23 0.18 -0.02 1 2 3 4 5 -1.39 1.39 LOC651175 1.27 0.07 -1.32 -0.26 0.74 1 2 3 4 5 -1.39 1.39 HS.404057 -0.29 1.11 -0.28 -0.29 -0.15 1 2 3 4 5 -1.39 1.39 LIN28 0.19 2.18 0.79 -0.59 -0.03 1 2 3 4 5 -1.39 1.39 LOC648066 0.71 0.85 -0.54 0.82 -0.39 1 2 3 4 5 -1.39 1.39 HS.568294 -0.13 1.54 0.15 0.05 0.20 1 2 3 4 5 -1.39 1.39 HS.576531 1.01 0.80 -0.59 0.13 0.44 1 2 3 4 5 -1.39 1.39 DEFB128 -0.07 1.52 0.13 -0.42 -0.29 1 2 3 4 5 -1.39 1.39 MAGEA9 0.62 1.64 0.25 -0.58 0.04 1 2 3 4 5 -1.39 1.39 HS.543724 -0.99 0.98 -0.41 0.86 0.62 1 2 3 4 5 -1.39 1.39 LOC389906 0.31 0.99 -0.40 1.52 1.78 1 2 3 4 5 -1.39 1.39 HS.570156 0.25 0.93 -0.46 0.36 -0.36 1 2 3 4 5 -1.39 1.39 HS.181500 -0.43 1.07 -0.32 -0.04 -0.34 1 2 3 4 5 -1.39 1.39 MMP1 -0.20 1.33 -0.06 1.45 -0.35 1 2 3 4 5 -1.39 1.39 HS.536623 -0.25 1.18 -0.21 0.12 -0.21 1 2 3 4 5 -1.39 1.39 LOC644243 -0.16 1.70 0.31 -0.14 0.27 1 2 3 4 5 -1.39 1.39 HS.147369 -0.54 0.99 -0.40 0.90 -0.61 1 2 3 4 5 -1.39 1.39 LOC647060 0.60 1.14 -0.25 0.92 -0.01 1 2 3 4 5 -1.39 1.39 HS.203337 -0.35 1.04 -0.36 -0.41 -0.49 1 2 3 4 5 -1.39 1.39 CXCL6 -O.22; 1.14 -0.25 -0.63 -0.35 1 2 3 4 5 -1.39 1.39

LOC391282 -1.22: 1.39 0.00 2.75 1.15 1 2 3 4 5 -1.39 1.39

LOC642428 -0.33; 1.44 0.04 1.22 1.07 1 2 3 4 5 -1.39 1.39 LOC646029 1 .0 8 1.16 -0.24 0.40 0.29 1 2 3 4 5 -1.39 1.39 LOC642580 0.2 0.83 -0.57 -0.39 0.10 1 2 3 4 5 -1.39 1.39 LOC648668 5.00 1.14 -0.25 0.12 0.29 1 2 3 4 5 -1.39 1.39 HS.517041 1.03 0.56 -0.84 4.29 0.56 1 2 3 4 5 -1.39 1.39 HS.538333 1.671 0.65 -0.75 0.20 0.43 1 2 3 4 5 -1.39 1.39 HS.60764 0.31 1.87 0.48 -0.16 -0.18 1 2 3 4 5 -1.40 1.40 HS.561362 0.02 0.89 -0.51 3.36 -0.38 1 2 3 4 5 -1.40 1.40 LOC653420 1.78 0.49 -0.90 0.25 -0.03 1 2 3 4 5 -1.40 1.40 HS.365312 0.44 0.16 -1.24 -0.45 -0.03 1 2 3 4 5 -1.40 1.40 RFXDC1 -0.21 1.41 0.01 -0.08 0.00 1 2 3 4 5 -1.40 1.40 FCRL4 -0.99 -0.38 -1.77 3.94 0.49 1 2 3 4 5 -1.40 1.40 LOC652472 -0.53 1.04 -0.36 -0.60 0.11 1 2 3 4 5 -1.40 1.40 T M E 26 -0.66 0.84 -0.55 1.12 0.94 1 2 3 4 5 -1.40 1.40 HS.434108 -0.31 1.29 -0.11 -0.39 -0.46 1 2 3 4 5 -1.40 1.40 PRM3 -0.21 1.11 -0.29 -0.10 0.24 1 2 3 4 5 -1.40 1.40 HS.570731 2.15 1.17 -0.23 -0.66 2.88 1 2 3 4 5 -1.40 1.40 HS.559605 0.22 1.83 0.44 -0.63 -0.11 1 2 3 4 5 -1.40 1.40 TBL1Y 0.46 1.21 -0.18 0.05 0.72 1 2 3 4 5 -1.40 1.40 HS.200048 -0.50 0.92 -0.48 -0.35 -0.46 1 2 3 4 5 -1.40 1.40 CPS1 0.02 0.66 -0.74 -0.70 1.42 1 2 3 4 5 -1.40 1.40 LOC643203 0.08 1.60 0.20 -0.14 -1.02 1 2 3 4 5 -1.40 1.40 HS.516784 0.19 1.04 -0.36 1.06 -0.54 1 2 3 4 5 -1.40 1.40 C150RF51 1.98 0.51 -0.90 -1.02 1.13 1 2 3 4 5 -1.40 1.40 ANKRD13B 0.51 1.12 -0.29 0.09 0.04 1 2 3 4 5 -1.40 1.40 LOC440407 0.05 1.61 0.20 0.26 0.01 1 2 3 4 5 -1.40 1.40 MKRN3 -0.03 1.38 -0.03 -0.02 -0.01 1 2 3 4 5 -1.40 1.40 TTTYll 0.03 1.04 -0.37 0.90 -0.25 1 2 3 4 5 -1.41 1.41 Table 3 133 LOC728498 1.43 0.02 0.01 0.22 1 2 3 4 5 -1.41 1.41 PIP5KL1 1.41 0.00 -0.09 0.10 1 2 3 4 5 -1.41 1.41 FU22184 1.10 -0.30 -0.20 1.43 1 2 3 4 5 -1.41 1.41 FU46154 1.03 -0.38 2.51 -0.03 1 2 3 4 5 -1.41 1.41 HS.538981 1.51 0.10 0.81 2.01 1 2 3 4 5 -1.41 1.41 HS.545096 1.48 0.08 -0.31 0.05 1 2 3 4 5 -1.41 1.41 HS.570617 1.33 -0.07 0.00 -0.10 1 2 3 4 5 -1.41 1.41 LOC645879 1.30 -0.11 -0.21 0.53 1 2 3 4 5 -1.41 1.41 HS.543672 1.29 -0.12 0.79 0.79 1 2 3 4 5 -1.41 1.41 LOC649200 0.65 -0.76 1.14 1.19 1 2 3 4 5 -1.41 1.41 PAGE2B 0.59 -0.82 1.95 -0.94 1 2 3 4 5 -1.41 1.41 HS.148700 0.81 -0.60 2.23 -0.31 1 2 3 4 5 -1.41 1.41 LOC652522 1.78 0.37 0.46 -0.75 1 2 3 4 5 -1.41 1.41 SLC34A1 1.17 -0.25 -0.03 -0.24 1 2 3 4 5 -1.41 1.41 LOC646976 1.35 -0.06 0.06 -0.01 1 2 3 4 5 -1.41 1.41 C180RF34 1.88 0.47 -0.07 -0.69 1 2 3 4 5 -1.41 1.41 ART5 0.14 -1.27 -1.34 -0.98 1 2 3 4 5 -1.41 1.41 HS.436018 1.24 -0.17 -0.46 -0.18 1 2 3 4 5 -1.41 1.41 HS.545387 0.97 -0.44 0.04 0.00 1 2 3 4 5 -1.41 1.41 LOC653674 0.61 -0.81 2.15 1.41 1 2 3 4 5 -1.41 1.41 SCARF1 1.41 0.00 0.21 0.97 1 2 3 4 5 -1.41 1.41 NFASC 1.13 -0.29 -0.01 -0.09 1 2 3 4 5 -1.42 1.42 HS.563591 1.22 -0.20 0.32 -0.23 1 2 3 4 5 -1.42 1.42 OR7E24 0.90 -0.52 0.28 1.11 1 2 3 4 5 -1.42 1.42 CRB1 1.08 -0.33 -0.71 1.06 1 2 3 4 5 -1.42 1.42 DPPA5 0.97 -0.44 0.42 -0.19 1 2 3 4 5 -1.42 1.42 LOC644413 0.43 -0.99 -0.01 0.54 1 2 3 4 5 -1.42 1.42 HS.538383 0.73 -0.69 1.37 0.12 1 2 3 4 5 , -1.42 1.42 KIAA0672 2.21 0.79 0.74 0.13 1 2 3 4 5 -1.42 1.42 HS.541677 1.41 -0.01 -0.36 1.13 1 2 3 4 5 ; -1.42 1.42 HS.543901 0.77 -0.65 0.50 -0.09 1 2 3 4 5 -1.42 1.42 HS.114035 0.59 -0.83 0.56 0.31 1 2 3 4 5 -1.42 1.42 LOC441326 0.87 -0.55 0.14 0.48 1 2 3 4 5 -1.42 1.42 HS.541352 1.65 0.23 0.68 1.44 1 2 3 4 5 -1.42 1.42 DENND2A 0.04 -1.38 0.89 -0.52 1 2 3 4 5 -1.42 1.42 HS.574959 0.44 -0.98 0.46 -0.37 1 2 3 4 5 -1.42 1.42 OSAP 0.73 -0.69 1.01 1.91 1 2 3 4 5 -1.42 1.42 TM4SF20 0.88 -0.54 0.31 -1.38 1 2 3 4 5 -1.42 1.42 HS.199881 0.98 -0.44 -0.79 3.15 1 2 3 4 5 -1.42 1.42 HS.541868 1.25 -0.18 0.16 0.15 1 2 3 4 5 -1.42 1.42 LOC647058 1.29 -0.14 2.42 3.08 1 2 3 4 5 -1.42 1.42 HS.543592 1.87 0.45 0.77 1.65 1 2 3 4 5 -1.42 1.42 LOC343927 0.97 -0.45 -0.27 -0.14 1 2 3 4 5 -1.42 1.42 HS.572521 -0.05 -1.47 -1.05 2.77 1 2 3 4 5 -1.42 1.42 HS.575321 1.34 -0.08 0.45 1.87 1 2 3 4 -1.42 1.42 HS.256249 1.58 0.15 -0.85 0.04 1 2 3 4 5 -1.42 1.42 LOC644305 2.03 0.60 3.27 2.05 1 2 3 4 5 -1.42 1.42 FU46321 0.93 -0.49 0.26 2.47 1 2 3 4 5 -1.43 1.43 HS.539114 1.37 -0.06 0.38 -0.47 1 2 3 4 5 -1.43 1.43 Table 3 134 LOC650712 0.62 2.47 1.05 · 1.29 1.69 1 2 3 4 5 -1.43 1.43 FOSL1 -0.23 1.21 -0.22 -0.08 -0.22 1 2 3 4 5 -1.43 1.43 STK17A -0.10 1.28 -0.15 0.17 -0.32 1 2 3 4 5 -1.43 1.43 PKD2L2 2.73 2.12 0.70 -0.22 0.62 1 2 3 4 5 -1.43 1.43 ANGPTL7 2.03 1.01 -0.42 0.39 1.56 1 2 3 4 5 -1.43 1.43 HS.537685 1.87 1.15 -0.27 2.32 0.37 1 2 3 4 5 -1.43 1.43 HS.563938 -0.63 1.41 -0.01 0.53 -0.40 1 2 3 4 5 -1.43 1.43 LOC645745 0.29 2.01 0.58 -0.04 0.06 1 2 3 4 5 -1.43 1.43 HS.547238 1.22 1.21 -0.22 -0.16 0.70 1 2 3 4 5 -1.43 1.43 LYG2 0.19 1.40 -0.03 3.88 -0.27 1 2 3 4 5 -1.43 1.43 HS.565952 1.40 1.77 0.34 1.63 3.22 1 2 3 4 5 -1.43 1.43 HS.570993 0.36 2.39 0.96 -0.75 -0.52 1 2 3 4 5 -1.43 1.43 PTF1A -0.08 0.10 -1.33 0.64 0.53 1 2 3 4 5 -1.43 1.43 LOC653570 1.70 1.57 0.14 -0.09 0.06 1 2 3 4 5 -1.43 1.43 ONECUT1 1.04 1.62 0.19 -0.08 -0.56 1 2 3 4 5 -1.43 1.43 ZNF423 2.99 0.48 -0.95 -0.20 0.20 1 2 3 4 5 -1.43 1.43 HS.580150 -0.84 1.78 0.35 0.26 1.55 1 2 3 4 5 -1.43 1.43 HS.569960 1.51 1.03 -0.40 0.02 0.02 1 2 3 4 5 -1.43 1.43 HS.125959 0.01 1.39 -0.05 -0.53 -0.38 1 2 3 4 5 -1.43 1.43 HS.385801 1.97 1.14 -0.30 -0.06 1.22 1 2 3 4 5 -1.43 1.43 HS.540847 -0.07 0.93 -0.50 0.62 0.31 1 2 3 4 5 -1.43 1.43 HS.563743 0.04 0.61 -0.82 -0.28 1.21 1 2 3 4 5 -1.43 1.43 FU41170 0.53 1.53 0.10 0.31 -0.59 1 2 3 4 5 -1.43 1.43 LOC652231 0.03 1.11 -0.32 -0.36 -0.27 1 2 3 4 5 -1.43 1.43 HS.545975 1.56 0.42 -1.01 -0.56 -0.42 1 2 3 4 5 -1.43 1.43 HS.554319 -0.46 1.10 -0.34 2.27 5.91 1 2 3 4 5 -1.43 1.43 LOC642148 -0.64 1.21 -0.22 4.53 -0.15 1 2 3 4 5 -1.43 1.43 HS.123543 -0.18 1.39 -0.04 1.04 -0.52 1 2 3 4 5 -1.43 1.43 HS.541570 -0.27 0.74 -0.69 -0.08 0.64 1 2 3 4 5 -1.43 1.43 HS.159454 -0.58: 1.42 -0.01 -1.64 0.43 1 2 3 4 5 -1.44 1.44 SOX7 -0.28 1.23 -0.21 1.25 -0.07 1 2 3 4 5 -1.44 1.44 HS.55315 -0.11 1.56 0.13 0.64 0.68 1 2 3 4 5 -1.44 1.44 LOC645164 -0.64 1.15 -0.28 1.60 0.07 1 2 3 4 5 -1.44 1.44 LOC642775 -0.14 0.95 -0.49 -0.34 -0.87 1 2 3 4 5 -1.44 1.44 HS.290611 -0.09 2.00 0.56 0.75 0.26 1 2 3 4 5 -1.44 1.44 HS.581165 -0.18 0.84 -0.60 -0.14 -0.73 1 2 3 4 5 -1.44 1.44 RPL3L -0.88 0.70 -0.74 3.09 -0.13 1 2 3 4 5 -1.44 1.44 SPOCK3 2.72 0.12 -1.32 0.03 0.26 1 2 3 4 5 -1.44 1.44 LOC652217 0.09 1.40 -0.04 0.89 -0.05 1 2 3 4 5 -1.44 1.44 TCEB1P3 0.38 1.19 -0.25 0.21 0.51 1 2 3 4 5 -1.44 1.44 HS.537533 0.75 0.80 -0.64 0.18 1.14 1 2 3 4 5 -1.44 1.44 HS.513580 0.04 1.14 -0.30 0.16 0.58 1 2 3 4 5 -1.44 1.44 HS.116182 -0.75 1.44 0.00 3.86 3.51 1 2 3 4 5 -1.44 1.44 HS.221951 -0.25 1.74 0.30 0.18 -0.05 1 2 3 4 5 -1.44 1.44 IQCF3 2.80 2.65 1.20 1.52 0.21 1 2 3 4 5 -1.44 1.44 HS.434335 -0.33 1.29 -0.16 0.20 0.10 1 2 3 4 5 -1.44 1.44 AKR1C1 1.28 0.85 -0.60 -1.29 0.78 1 2 3 4 5 -1.44 1.44 LOC645983 -0.40 0.38 -1.06 1.62 -0.84 1 2 3 4 5 -1.44 1.44 LOC649320 -0.28 1.07 -0.37 1.05 -0.27 1 2 3 4 5 -1.44 1.44 Table 3 HS.155782 -0.04 1.12 -0.33 0.57 1.92 1 2 3 4 5 -1.44 1.44 HS.572260 0.11 1.19 -0.26 -0.29 0.33 1 2 3 4 5 -1.44 1.44 LOC644196 0.05 1.21 -0.23 -0.85 1.11 1 2 3 4 5 -1.44 1.44 RDH12 -0.39 1.37 -0.08 -0.35 0.19 1 2 3 4 5 -1.45 1.45 TMEM27 -0.16 1.22 -0.23 -0.12 0.43 1 2 3 4 5 ! -1.45 1.45 HS.339592 -0.03 1.21 -0.24 -0.35 0.27 1 2 3 4 5 -1.45 1.45 PAGEl 1.19 0.74 -0.70 -0.09 -0.90 1 2 3 4 5 -1.45 1.45 SAR1P3 1.97 0.47 -0.98 -0.75 -0.82 1 2 3 4 5 -1.45 1.45 SHOX 0.60 1.41 -0.03 -0.22 1.40 1 2 3 4 5 -1.45 1.45 HS.147567 -0.47 1.50 0.05 0.48 0.41 1 2 3 4 5 -1.45 1.45 LOC644277 -0.19 1.14 -0.30 -0.30 0.63 1 2 3 4 5 -1.45 1.45 C60RF122 0.88 0.31 -1.14 -0.56 -0.08 1 2 3 4 5 -1.45 1.45 HS.543221 -0.45 1.05 -0.39 -0.25 -0.32 1 2 3 4 5 -1.45 1.45 KIAA1622 -0.07 1.08 -0.37 0.48 0.03 1 2 3 4 5 -1.45 1.45 SPINK6 -0.23 0.64 -0.81 0.48 0.25 1 2 3 4 5 -1.45 1.45 LOC651373 0.83 0.55 -0.90 1.11 0.06 1 2 3 4 5 -1.45 1.45 LOC442388 -0.02 0.85 -0.60 -0.32 -0.02 1 2 3 4 5 -1.45 1.45 HS.370611 0.40 1.20 -0.24 0.18 0.22 1 2 3 4 5 -1.45 1.45 HS.117266 0.13 1.25 -0.20 0.94 -0.60 1 2 3 4 5 -1.45 1.45 HS.538322 0.13: 0.87 -0.58 0.43 0.28 1 2 3 4 5 -1.45 1.45 HS.545544 -0.05; 1.17 -0.28 -0.03 -0.20 1 2 3 4 5 -1.45 1.45 LOC653146 1.90 0.71 -0.74 -0.28 0.24 1 2 3 4 5 -1.45 1.45 LOC645947 -0.46 1.60 0.15 -0.23 0.22 1 2 3 4 5 -1.45 1.45 LOC441239 0.46 1.18 -0.28 1.05 0.94 1 2 3 4 5 -1.45 1.45 HS.571047 -0.17 1.32 -0.13 0.06 -0.33 1 2 3 4 5 -1.45 1.45 OR2B6 1.13 0.68 -0.77 0.95 0.09 1 2 3 4 5 -1.45 1.45 HS.208645 1.08 3.00 1.54 0.40 1.48 1 2 3 4 5 -1.45 1.45 HS.555549 -0.43' 1.38 -0.07 -0.25 -0.07 1 2 3 4 5 -1.45 1.45 HS.515917 -0.84 0.98 -0.47 3.00 0.83 1 2 3 4 5 -1.45 1.45 LOC645010 1.40 0.16 -1.30 -1.12 1.13 1 2 3 4 5 -1.45 1.45 HS.541532 0.18 1.46 0.00 -0.23 0.50 1 2 3 4 5 -1.45 1.45 HS.540359 -0.24 1.60 0.15 0.14 0.15 1 2 3 4 5 -1.45 1.45 MGC46336 -0.56 0.73 -0.72 0.21 0.07 1 2 3 4 5 -1.46 1.46 HS.127925 1.98 1.08 -0.37 -0.41 -0.21 1 2 3 4 5 -1.46 1.46 HS.543973 0.21 1.29 -0.17 0.82 0.53 1 2 3 4 5 -1.46 1.46 HS.86508 -0.33 0.31 -1.15 -0.11 0.40 1 2 3 4 5 -1.46 1.46 SYCP2L 0.35 1.13 -0.33 0.44 0.36 1 2 3 4 5 -1.46 1.46 HS.544213 1.31 1.08 -0.38 0.38 0.01 1 2 3 4 5 -1.46 1.46 HS.544398 0.13 1.36 -0.10 -0.51 0.11 1 2 3 4 5 -1.46 1.46 LOC643938 1.19 1.29 -0.17 0.33 0.02 1 2 3 4 5 -1.46 1.46 HS.133457 -0.05 0.41 -1.05 1.43 -1.14 1 2 3 4 5 -1.46 1.46 NR2E3 0.27 -0.19 -1.65 -0.66 0.03 1 2 3 4 5 -1.46 1.46 LOC649088 1.36 2.20 0.74 -0.10 1.86 1 2 3 4 5 -1.46 1.46 HS.131110 3.64 0.40 -1.06 -0.98 0.61 1 2 3 4 5 -1.46 1.46 DUOX2 -1.23 0.59 -0.88 0.18 1.23 1 2 3 4 5 -1.46 1.46 LOC643883 -0.84 2.20 0.74 0.73 1.02 1 2 3 4 5 -1.46 1.46 FU32214 -1.29 -0.11 -1.58 1.20 -0.42 1 2 3 4 5 -1.46 1.46 LOC647710 1.78 1.35 -0.12 0.22 0.04 1 2 3 4 5 -1.46 1.46 HS.537623 0.11 0.78 -0.68 -0.15 -0.44 1 2 3 4 5 -1.46 1.46 Table 3 136 HS.569832 0.22 0.71 -0.75 -0.57 -0.76 1 2 3 4 5 -1.46 1.46 HS.564343 -0.64 1.96 0.49 0.89 -0.51 1 2 3 4 5 -1.46 1.46 HS.553283 -0.19 1.45 -0.02 0.29 0.15 1 2 3 4 5 -1.46 1.46 LYPD6 1.20 1.37 -0.09 0.69 -0.20 1 2 3 4 5 -1.46 1.46 LOC647129 0.21 0.96 -0.50 -0.08 -0.60 1 2 3 4 5 -1.46 1.46 HS.581542 -0.17 1.07 -0.40 0.20 -0.57 1 2 3 4 5 -1.46 1.46 HS.545408 4.14 1.02 -0.45 0.34 -0.11 1 2 3 4 5 -1.47 1.47 HS.577768 -0.35 1.48 0.01 -0.18 -0.06 1 2 3 4 5 -1.47 1.47 HS.567081 1.40 3.19 1.73 -0.41 -0.48 1 2 3 4 5 -1.47 1.47 HS.60681 0.56 1.18 -0.28 1.13 0.29 1 2 3 4 5 -1.47 1.47 HS.542968 -0.05 1.01 -0.46 -0.49 -0.17 1 2 3 4 5 -1.47 1.47 HS.584577 0.17 1.06 -0.41 -0.18 -0.21 1 2 3 4 5 -1.47 1.47 LOC400796 1.45 0.86 -0.61 -0.30 0.04 1 2 3 4 5 -1.47 1.47 LOC285500 0.35 1.34 -0.13 -0.26 -0.53 1 2 3 4 5 -1.47 1.47 HS.545116 1.04 1.60 0.13 0.26 0.57 1 2 3 4 5 -1.47 1.47 HS.566250 0.01 1.01 -0.46 -0.22 -0.24 1 2 3 4 5 -1.47 1.47 DNMT3L 0.09 0.55 -0.92 0.49 0.02 1 2 3 4 5 -1.47 1.47 LOC653043 -0.30 1.08 -0.39 -0.33 0.79 1 2 3 4 5 -1.47 1.47 HS.571517 1.29 1.67 0.20 0.83 -0.23 1 2 3 4 5 -1.47 1.47 OR4K1 -0.01 0.93 -0.54 0.25 0.46 1 2 3 4 5 -1.47 1.47 HS.416043 2.99 0.95 -0.52 -0.03 0.19 1 2 3 4 5 -1.47 1.47 LOC646299 1.69 0.96 -0.51 1.00 0.32 1 2 3 4 5 -1.47 1.47 HS.566168 -0.07 1.36 -0.11 -0.08 0.07 1 2 3 4 5 -1.47 1.47 HS.539135 -0.24 1.36 -0.11 1.30 0.13 1 2 3 4 5 -1.47 1.47 LOC650285 0.72 0.83 -0.65 0.08 -1.65 1 2 3 4 5 -1.47 1.47 HS.48372 1.12 ; 0.60 -0.87 -0.98 0.87 1 2 3 4 5 -1.47 1.47 HS.147007 o.7i 4.78 3.31 2.16 0.06 1 2 3 4 5 -1.48 1.48 HS.382016 -0.34 1.34 -0.14 -0.20 0.44 1 2 3 4 5 -1.48 1.48 LOC647082 1.27 5.14 3.67 4.17 1.78 1 2 3 4 5 -1.48 1.48 HS.566922 0.83 1.57 0.09 1.42 0.84 1 2 3 4 5 -1.48 1.48 HS.579678 0.52 : 1.72 0.24 0.10 0.42 1 2 3 4 5 -1.48 1.48 LOC650193 0.13 1.45 -0.03 0.86 2.41 1 2 3 4 5 -1.48 1.48 HS.387719 -0.58 1.16 -0.32 0.07 0.69 1 2 3 4 5 -1.48 1.48 LOC646456 -0.81 1.15 -0.33 -1.33 -1.41 1 2 3 4 5 -1.48 1.48 GAP43 0.35 1.71 0.23 0.09 -0.13 1 2 3 4 5 -1.48 1.48 HS.539886 0.03 0.75 -0.73 -0.58 0.16 1 2 3 4 5 -1.48 1.48 HS.218036 1.20 1.13 -0.35 -0.05 1.60 1 2 3 4 5 -1.48 1.48 HAS2 1.35 3.03 1.55 0.79 0.85 1 2 3 4 5 -1.48 1.48 LOC653664 1.14 1.38 -0.10 -0.31 -0.33 1 2 3 4 5 -1.48 1.48 HS.430300 0.69 1.05 -0.43 1.41 -0.10 1 2 3 4 -1.48 1.48 IFLTD1 2.92 2.14 0.66 1.49 0.35 1 2 3 4 5 -1.48 1.48 HS.580710 0.74 1.77 0.29 0.18 0.02 1 2 3 4 5 -1.48 1.48 C40RF7 -0.71 1.48 0.00 -0.60 0.18 1 2 3 4 5 -1.48 1.48 OR10J5 -0.53 1.05 -0.43 1.31 -0.02 1 2 3 4 5 -1.48 1.48 HS.548539 -0.13 1.06 -0.42 -0.14 2.20 1 2 3 4 5 -1.48 1.48 HS.545084 -0.83 1.30 -0.18 2.66 4.08 1 2 3 4 5 -1.48 1.48 HS.561235 2.29 1.44 -0.05 2.82 -0.10 1 2 3 4 5 -1.48 1.48 HS.582465 0.36 1.39 -0.10 0.06 0.80 1 2 3 4 5 -1.48 1.48 HS.543241 -0.15 2.01 0.53 1.43 -0.20 1 2 3 4 5 -1.49 1.49 Table 3 137 FKBP9 3.48 0.94 -0.55 1.52 -0.07 1 2 3 4 5 -1.49 1.49 HS.537602 0.46 0.70 -0.79 0.55 0.29 1 2 3 4 5 -1.49 1.49 FKSG49 -0.71 1.77 0.28 0.21 -0.92 1 2 3 4 5 -1.49 1.49 HS.542414 2.25 2.26 0.77 -0.13 1.03 1 2 3 4 5 -1.49 1.49 HS.148538 -0.2'5 2.05 0.56 0.29 -0.11 1 2 3 4 5 -1.49 1.49 HS.143732 -0.96 1.65 0.16 -0.12 1.30 1 2 3 4 5 -1.49 1.49 HS.542579 0.74 1.14 -0.35 0.23 1.49 1 2 3 4 5 -1.49 1.49 HS.583156 0.80 0.86 -0.63 0.32 -0.53 1 2 3 4 5 -1.49 1.49 HS.399833 1.52 1.75 0.25 0.15 -0.11 1 2 3 4 5 -1.49 1.49 G M 6 0.45 -0.14 -1.63 -0.53 1.38 1 2 3 4 5 -1.49 1.49 HS.563427 -0.53 0.98 -0.51 0.10 0.14 1 2 3 4 5 -1.49 1.49 HS.208723 0.98 0.82 -0.67 0.27 1.06 1 2 3 4 5 -1.49 1.49 HS.557879 -0.32 1.23 -0.26 -0.62 -0.92 1 2 3 4 5 -1.49 1.49 HS.543139 1.14 2.37 0.88 0.10 1.39 1 2 3 4 5 -1.49 1.49 HS.564168 1.36 1.50 0.00 0.32 0.17 1 2 3 4 5 -1.49 1.49 HS.559585 -0.60 1.36 -0.13 0.15 -0.40 1 2 3 4 5 -1.49 1.49 HS.538304 -0.62 0.77 -0.72 0.03 -0.90 1 2 3 4 5 -1.49 1.49 PRY2 -0.22 1.24 -0.26 0.89 -0.24 1 2 3 4 5 -1.49 1.49 FAM43B 0.21 0.99 -0.50 0.55 0.46 1 2 3 4 5 -1.50 1.50 TCP10L2 -0.69 1.39 -0.11 1.12 0.83 1 2 3 4 5 -1.50 1.50 HS.576342 0.13 1.89 0.39 1.21 0.03 1 2 3 4 5 -1.50 1.50 HS.112680 -0.29 2.26 0.76 2.59 -0.28 1 2 3 4 5 -1.50 1.50 LOC644808 -0.28 1.09 -0.40 -0.29 -1.23 1 2 3 4 5 -1.50 1.50 VAPB 0.23 1.26 -0.24 -0.16 -0.57 1 2 3 4 5 -1.50 1.50 LOC644326 -0.51 2.92 1.43 1.47 0.11 1 2 3 4 5 -1.50 1.50 FU30375 -1.36 1.54 0.04 0.54 -0.86 1 2 3 4 5 -1.50 1.50 HS.575821 0.73 0.89 -0.61 1.18 0.83 1 2 3 4 5 -1.50 1.50 HS.543008 -0.82 0.96 -0.54 -0.77 1.56 1 2 3 4 5 -1.50 1.50 OR5AS1 0.46 1.64 0.14 -0.34 -0.36 1 2 3 4 5 -1.50 1.50 HS.311524 1.41 1.06 -0.44 0.93 0.55 1 2 3 4 5 -1.50 1.50 HS.542191 0.03 1.70 0.20 1.28 0.02 1 2 3 4 5 -1.50 1.50 HS.345497 0.31 1.00 -0.50 0.17 0.24 1 2 3 4 5 -1.50 1.50 HS.161875 0.58 0.26 -1.25 0.44 0.47 1 2 3 4 5 -1.50 1.50 UTP20 0.65 1.23 -0.27 0.88 -0.17 1 2 3 4 5 -1.50 1.50 VWA2 2.49 1.84 0.34 1.40 3.13 1 2 3 4 5 -1.50 1.50 HS.490417 0.49 1.62 0.12 0.10 0.03 1 2 3 4 5 -1.50 1.50 HS.134945 4.89 1.86 0.36 1.21 -0.60 1 2 3 4 5 -1.50 1.50 HS.581745 -0.57 1.97 0.47 1.83 -0.14 1 2 3 4 5 -1.50 1.50 LOC645278 0.43 1.64 0.14 0.24 1.15 1 2 3 4 5 -1.50 1.50 HHIP 1.60 1.28 -0.23 -0.39 0.19 1 2 3 4 5 -1.50 1.50 LOC644975 -0.27 1.43 -0.07 -0.23 -0.23 1 2 3 4 5 -1.50 1.50 0R11H6 3.41 1.61 0.10 2.51 1.00 1 2 3 4 5 -1.51 1.51 SNORD26 -0.10 2.12 0.61 -0.98 0.47 1 2 3 4 5 -1.51 1.51 PRAMEF19 -0.08 1.13 -0.37 0.52 -0.16 1 2 3 4 5 -1.51 1.51 LOC642588 2.07 1.02 -0.48 0.37 0.13 1 2 3 4 5 -1.51 1.51 HS.568599 0.17 1.24 -0.27 -0.38 -0.34 1 2 3 4 5 -1.51 1.51 CEACAM6 -0.62 2.15 0.64 -0.66 -0.24 1 2 3 4 5 -1.51 1.51 HS.561363 0.41 1.55 0.04 0.72 1.80 1 2 3 4 5 -1.51 1.51 HS.570747 1.17 0.63 -0.88 2.66 1.10 1 2 3 4 5 -1.51 1.51 Table 3 138 HS.437660 -0.68 0.80 -0.70 -0.71 0.99 1 2 3 4 5 -1.51 1.51 AMAC1L1 -0.20 1.20 -0.31 -0.15 0.14 1 2 3 4 5 -1.51 1.51 APBB2 0.72 1.61 0.10 0.63 -0.12 1 2 3 4 5 -1.51 ; 1.51 LOC388177 -0.23 0.91 -0.60 -0.24 0.25 1 2 3 4 5 -1.51 1.51 HS.539518 0.03 1.54 0.03 2.78 -0.49 1 2 3 4 5 -1.51 1.51 TEK -0.11 1.13 -0.38 0.25 -0.37 1 2 3 4 5 -1.51 1.51 LOC643328 -0.42 0.97 -0.54 -0.39 -0.82 1 2 3 4 5 -1.51 1.51 HS.148233 0.05 -0.46 -1.97 0.88 1.13 1 2 3 4 5 -1.51 1.51 SPINK1 2.80 1.07 -0.45 0.27 0.32 1 2 3 4 5 -1.51 1.51 HS.547862 -0.05 0.28 -1.24 -0.50 -0.51 1 2 3 4 5 -1.51 1.51 HS.571662 5.64 1.42 -0.10 0.98 -0.04 1 2 3 4 5 -1.51 1.51 HS.334122 0.13 0.91 -0.60 3.52 0.23 1 2 3 4 5 -1.51 1.51 LOC650680 0.30 1.50 -0.01 -0.27 -0.13 1 2 3 4 5 -1.51 1.51 KLK8 1.68 1.12 -0.40 1.18 1.22 1 2 3 4 5 -1.51 1.51 AKR1C2 0.10 1.32 -0.20 5.70 0.09 1 2 3 4 5 -1.51 1.51 HS.338140 1.04 0.94 -0.57 -0.08 0.36 1 2 3 4 5 -1.51 1.51 LOC646713 0.74 1.37 -0.15 0.43 0.51 1 2 3 4 5 -1.51 1.51 FRK -0.88 3.00 1.48 2.53 -1.19 1 2 3 4 5 -1.51 1.51 R3HDML 1.90 1.03 -0.48 0.07 -0.54 1 2 3 4 5 -1.52 1.52 HS.539301 0.01 0.75 -0.77 -1.00 -0.24 1 2 3 4 5 -1.52 1.52 BOLL -0.16 0.74 -0.77 1.36 -0.41 1 2 3 4 5 -1.52 1.52 LOC647873 -0.09 1.42 -0.10 -0.08 -0.21 1 2 3 4 5 -1.52 1.52 LOC642168 -0.31 1.37 -0.14 0.60 -0.27 1 2 3 4 5 -1.52 1.52 HS.430095 -0.62 0.94 -0.58 0.04 1.78 1 2 3 4 5 -1.52 1.52 HS.131360 -0.57 2.41 0.89 0.10 0.97 1 2 3 4 -1.52 1.52 HS.577839 -0.02 1.39 -0.12 -0.09 0.08 1 2 3 4 5 -1.52 1.52 SRY 1.58 0.67 -0.85 0.66 0.56 1 2 3 4 5 -1.52 1.52 HS.575588 2.55 1.12 -0.40 -0.24 -0.07 1 2 3 4 5 -1.52 1.52 LOC652548 4.07 0.91 -0.61 -0.96 0.23 1 2 3 4 5 -1.52 1.52 HS.541164 0.08 1.55 0.03 0.32 -0.37 1 2 3 4 5 ' -1.52 1.52 HS.455693 0.31 0.71 -0.81 1.31 3.47 1 2 3 4 5 -1.52 1.52 CASP14 1.05 1.21 -0.31 -0.42 0.00 1 2 3 4 5 -1.52 1.52 HS.584100 1.03 0.04 -1.49 2.30 3.81 1 2 3 4 5 -1.52 1.52 HS.539067 0.46 0.51 -1.01 2.09 -1.06 1 2 3 4 5 -1.52 1.52 HS.552272 -0.46 1.31 -0.21 0.95 -0.31 1 2 3 4 5 -1.52 1.52 CCL15 -0.50 1.21 -0.31 -0.18 0.50 1 2 3 4 5 -1.52 1.52 HS.513786 -0.36 1.63 0.10 1.87 0.93 1 2 3 4 5 -1.52 1.52 HS.571157 1.67 2.01 0.48 2.53 0.76 1 2 3 4 5 -1.52 1.52 LOC339862 1.31 1.16 -0.36 -0.21 0.69 1 2 3 4 5 : -1.53 1.53 ERAS -0.39 1.55 0.03 -0.63 0.07 1 2 3 4 5 -1.53 1.53 UPP2 -0.81 1.18 -0.35 0.58 -0.12 1 2 3 4 5 -1.53 1.53 HS.539069 0.05 1.58 0.05 0.32 0.45 1 2 3 4 5 -1.53 1.53 SEMG2 -0.78 0.63 -0.89 1.47 -1.67 1 2 3 4 5 ; -1.53 1.53 HS.201443 -0.52 0.92 -0.61 0.43 -0.82 1 2 3 4 5 -1.53 1.53 TPTE 3.46 0.97 -0.55 1.32 -0.51 1 2 3 4 5 -1.53 1.53 HS.580960 1.38 0.69 -0.84 -0.50 0.42 1 2 3 4 5 -1.53 1.53 TTTY16 0.59 1.74 0.21 -0.23 0.10 1 2 3 4 5 -1.53 1.53 HS.560743 -0.64 0.46 -1.07 0.63 -0.25 1 2 3 4 5 -1.53 1.53 HS.562527 I.23 3.06 1.53 -0.29 0.79 1 2 3 4 5 -1.53 1.53 Table 3 139

HS.136279 1.20 1.07 -0.46 0.57 0.13 1 2 3 4 5 -1.53 1.53 HS.542115 1.46 1.16 -0.37 0.43 -0.22 1 2 3 4 5 -1.53 1.53

GPR157 -0.09 -0.13 -1.66 4.32 -0.80 1 2 3 4 5 : -1.53 1.53

HS.110783 0.99 1.20 -0.33 0.67 0.54 1 2 3 4 5 : -1.53 1.53 HS.303934 -0.01 1.51 -0.02 0.34 0.68 1 2 3 4 5 -1.53 1.53 HS.541749 -0.36 1.80 0.27 0.66 0.33 1 2 3 4 5 -1.53 1.53 TSNARE1 0.01 1.78 0.25 0.20 0.36 1 2 3 4 5 -1.53 1.53 LOC652735 2.10 1.42 -0.11 0.22 0.25 1 2 3 4 5 -1.53 1.53 HS.546125 -0.17 1.30 -0.24 1.00 -0.24 1 2 3 4 5 -1.53 1.53 LOC644734 -0.19 1.20 -0.33 -0.54 -0.56 1 2 3 4 5 -1.53 1.53 HS.528556 0.85 2.03 0.50 0.51 0.35 1 2 3 4 5 -1.53 1.53 HS.519477 -0.76 1.08 -0.45 -0.12 -1.09 1 2 3 4 5 -1.53 1.53 HS.541638 0.00 1.31 -0.23 -0.21 -0.34 1 2 3 4 5 -1.53 1.53 HS.534767 0.15 1.63 0.09 0.88 -0.18 1 2 3 4 5 -1.53 1.53 ETV4 -0.89 1.61 0.08 -0.10 -0.42 1 2 3 4 5 -1.53 1.53 HS.566037 0.53 1.02 -0.52 1.25 -0.14 1 2 3 4 5 -1.54 1.54 HS.437524 4.96 0.43 -1.10 1.60 0.07 1 2 3 4 5 -1.54 1.54 HS.26651 0.05 1.58 0.04 -0.04 0.79 1 2 3 4 5 -1.54 1.54 C1QL4 -1.49 0.80 -0.74 1.63 0.71 1 2 3 4 5 -1.54 1.54 TBX20 -0.64 1.12 -0.42 0.25 1.79 1 2 3 4 5 -1.54 1.54 EFHA2 -0.11 1.45 -0.08 -0.11 -0.17 1 2 3 4 5 -1.54 1.54 HS.364594 1.01 1.15 -0.38 -0.69 -0.16 1 2 3 4 5 -1.54 1.54 HS.576170 3.43 2.17 0.63 2.21 0.39 1 2 3 4 5 -1.54 1.54 C160RF77 2.15 2.42 0.87 1.89 0.91 1 2 3 4 5 -1.54 1.54 HS.131571 -0.34 1.20 -0.34 -0.27 -0.41 1 2 3 4 5 -1.54 1.54 HS.208066 -0.30 1.34 -0.20 -0.37 -0.05 1 2 3 4 5 -1.54 1.54 HS.569548 -0.42 2.28 0.74 0.46 0.82 1 2 3 4 5 -1.54 1.54 LOC653735 -0.14 1.47 -0.07 -0.95 0.40 1 2 3 4 5 -1.54 1.54 LOC731827 0.27 1.72 0.18 -0.46 0.07 1 2 3 4 5 -1.54 1.54 LOC654165 1.58 0.85 -0.69 -0.58 0.50 1 2 3 4 5 -1.54 1.54 LOC644166 2.75 1.06 -0.48 -0.31 -0.15 1 2 3 4 5 -1.54 1.54 CXORF58 1.09 0.47 -1.08 -1.27 0.36 1 2 3 4 5 -1.54 1.54 HS.540258 0.85 1.58 0.03 0.12 0.26 1 2 3 4 5 -1.54 1.54 HS.562917 0.09 1.56 0.02 -0.25 -0.05 1 2 3 4 5 -1.55 1.55 LOC641772 0.24 1.12 -0.42 0.27 -0.25 1 2 3 4 5 -1.55 1.55 AADAC -0.51 2.08 0.53 -0.74 -0.38 1 2 3 4 5 -1.55 1.55 LOC647716 -0.59 0.71 -0.83 -0.20 -0.04 1 2 3 4 5 -1.55 1.55 HS.493457 2.61 0.36 -1.18 2.90 2.78 1 2 3 4 5 -1.55 1.55 LOC644827 -0.77 0.91 -0.64 -0.63 0.72 1 2 3 4 5 -1.55 1.55 ClOORFlll 0.09 0.93 -0.62 2.75 -0.23 1 2 3 4 5 -1.55 1.55 FU22447 0.14 2.47 0.92 -0.42 2.05 1 2 3 4 5 -1.55 1.55 LOC647649 0.03 1.33 -0.22 0.50 -0.13 1 2 3 4 5 -1.55 1.55 TCEAL6 2.47 3.97 2.42 1.01 -0.12 1 2 3 4 5 -1.55 1.55 HS.538511 -0.63 1.60 0.05 0.76 2.85 1 2 3 4 5 -1.55 1.55

RBMY1F -0.62 1.08 -0.47 -0.08 -0.92 1 2 3 4 5 ; -1.55 1.55 CC2D2A -0.24 1.03 -0.52 0.02 -0.22 1 2 3 4 5 -1.55 1.55 DCLK2 -0.34 1.26 -0.29 -0.12 0.73 1 2 3 4 5 -1.55 1.55 HS.581827 -0.46 0.91 -0.64 0.70 0.00 1 2 3 4 5 -1.55 1.55 FLT4 1.03 1.53 -0.02 -0.91 1.63 1 2 3 4 5 -1.55 1.55 Table 3 140 LOC643369 0.66 0.97 -0.58 -0.76 0.55 1 2 3 4 5 -1.55 1.55 HS.543277 0.35 1.34 -0.21 -0.26 0.06 1 2 3 4 5 -1.55 1.55 HS.554493 -0.13 2.45 0.90 0.23 1.17 1 2 3 4 5 -1.55 1.55 HS.365487 0.12 1.55 -0.01 -0.32 -0.52 1 2 3 4 5 -1.56 1.56 HS.562000 -0.28 1.38 -0.17 -0.45 -0.21 1 2 3 4 5 -1.56 1.56 HS.402814 -0.52 2.18 0.63 0.97 -0.56 1 2 3 4 5 -1.56 1.56 HS.549805 1.71 1.09 -0.47 -0.52 0.25 1 2 3 4 5 -1.56 1.56 HS.79353 -0.60 0.58 -0.97 -0.89 -0.50 1 2 3 4 5 -1.56 1.56 LOC651612 -0.02 0.93 -0.63 -0.99 0.08 1 2 3 4 5 -1.56 1.56 LOC646249 -0.60 0.96 -0.60 0.36 -0.57 1 2 3 4 5 -1.56 1.56 LOC728044 -0.52 0.87 -0.69 0.02 -0.01 1 2 3 4 5 -1.56 1.56 HS.232150 1.09 1.48 -0.08 1.45 0.43 1 2 3 4 5 -1.56 1.56 GH2 -0.28 1.20 -0.35 -0.44 -0.08 1 2 3 4 5 -1.56 1.56 EFCAB1 1.25 1.13 -0.43 0.13 0.04 1 2 3 4 5 -1.56 1.56 HS.133085 -0.11 1.06 -0.50 0.14 -0.39 1 2 3 4 5 -1.56 1.56 HS.576084 0.30 1.96 0.40 0.50 -0.19 1 2 3 4 5 -1.56 1.56 HISPPD1 0.71 0.84 -0.72 0.60 -0.12 1 2 3 4 5 -1.56 1.56 TSHB 0.57 1.26 -0.30 0.07 0.86 1 2 3 4 5 -1.56 1.56 HS.174158 -0.05 1.43 -0.13 0.32 -0.21 1 2 3 4 5 -1.56 1.56 LOC644097 -1.11 0.84 -0.72 -0.05 -1.34 1 2 3 4 5 -1.56 1.56 ARGFX 1.04 1.96 0.40 2.31 0.88 1 2 3 4 5 -1.56 1.56 HS.576483 -0.59 0.61 -0.95 -0.87 0.72 1 2 3 4 5 -1.56 1.56 HS.148659 -0.18 1.28 -0.28 -0.90 -0.60 1 2 3 4 5 -1.56 1.56 KIAA1975 0.02 1.57 0.01 -0.04 0.15 1 2 3 4 5 -1.56 1.56 FU45803 -0.39 1.23 -0.34 0.57 -0.40 1 2 3 4 5 -1.56 1.56 RAB41 0.46 0.84 -0.72 -0.44 1.23 1 2 3 4 5 -1.57 1.57 LOC642645 -0.47 1.87 0.30 1.33 -0.35 1 2 3 4 5 -1.57 1.57 AMELX 1.83 2.43 0.86 -0.33 -0.93 1 2 3 4 5 -1.57 1.57 HS.565325 2.16 3.39 1.83 -1.19 -0.52 1 2 3 4 5 -1.57 1.57 HS.580540 1.24 0.77 -0.80 4.23 2.53 1 2 3 4 5 -1.57 1.57 HS.539789 0.18 2.05 0.49 -0.46 -0.03 1 2 3 4 5 -1.57 1.57 HS.545221 -0.28 1.37 -0.20 -0.45 1.71 1 2 3 4 5 -1.57 1.57 FAM154B -0.72 2.96 1.39 -0.41 -1.20 1 2 3 4 5 -1.57 1.57 HS.534492 -0.24 1.49 -0.07 -0.06 -0.27 1 2 3 4 5 -1.57 1.57 IL23R 0.33 1.21 -0.36 0.27 0.17 1 2 3 4 5 -1.57 1.57 S EK3P 1.72 0.58 -0.99 0.80 -0.34 1 2 3 4 5 -1.57 1.57 LOC653108 -0.57 1.41 -0.16 0.70 1.03 1 2 3 4 5 -1.57 1.57 HS.282269 0.13 1.54 -0.03 0.14 -0.27 1 2 3 4 5 -1.57 1.57 KIR3DX1 -0.16 2.11 0.54 0.04 0.26 1 2 3 4 5 -1.57 1.57 HS.551877 0.10 0.85 -0.71 0.01 0.71 1 2 3 4 5 .-1.57 1.57 HS.578189 0.65 1.33 -0.24 0.24 -0.07 1 2 3 4 5 -1.57 1.57 HS.232413' 0.58 0.89 -0.68 1.22 -0.50 1 2 3 4 5 -1.57 1.57 HS.62716 2.11 0.64 -0.92 2.68 -0.21 1 2 3 4 5 -1.57 1.57 HS.577163 0.47 1.27 -0.30 0.16 0.36 1 2 3 4 5 -1.57 1.57 UGT1A8 0.95 1.37 -0.20 1.49 -0.12 1 2 3 4 5 -1.57 1.57 HS.574124 6.01 2.25 0.68 -0.44 0.87 1 2 3 4 5 -1.57 1.57 HS.561385 0.48 1.10 -0.47 2.42 2.84 1 2 3 4 5 -1.57 1.57 HS.487207 0.14 1.31 -0.27 0.86 2.69 1 2 3 4 5 -1.57 1.57 LOC646302 1.41 0.95 -0.63 -0.47 -0.47 1 2 3 4 5 -1.57 1.57 Table 3 141 C60RF146 1.18 0.77 -0.80 3.01 1.01 1 2 3 4 5 -1.57 1.57 HS.1832 -0.35 1.10 -0.47 -1.14 1.11 1 2 3 4 5 -1.57 1.57 HS.543749 0.03 0.51 -1.06 -1.04 2.48 1 2 3 4 5 -1.57 1.57 LOC399746 -0.54 1.45 -0.13 0.94 -0.41 1 2 3 4 5 -1.57 1.57 HS.544645 0.71 1.39 -0.18 1.03 -0.37 1 2 3 4 5 -1.57 1.57 PMP2 1.39 2.09 0.52 0.29 1.51 1 2 3 4 5 -1.57 1.57 DEFB110 0.14 0.75 -0.82 0.35 1.04 1 2 3 4 5 -1.57 1.57 LOC387931 1.07 2.01 0.43 -0.70 0.32 1 2 3 4 5 -1.57 1.57 CNTFR 2.41 2.35 0.77 2.67 -0.64 1 2 3 4 5 -1.58 1.58 LOC374491 0.51 1.57 -0.01 0.51 -0.38 1 2 3 4 5 -1.58 1.58 HS.441195 0.05 1.55 -0.03 0.29 -0.07 1 2 3 4 5 -1.58 1.58 LRRC7 0.29 1.68 0.11 1.46 0.31 1 2 3 4 5 -1.58 1.58 HS.441511 1.87 2.76 1.18 2.37 -0.36 1 2 3 4 5 -1.58 1.58 HS.524108 -0.43 1.23 -0.35 1.30 -0.37 1 2 3 4 5 -1.58 1.58 LOC402269 0.15 1.18 -0.40 -0.49 -0.41 1 2 3 4 5 -1.58 1.58 LOC158376 -0.66 0.97 -0.61 0.08 0.35 1 2 3 4 5 -1.58 1.58 CCDC78 1.74 0.61 -0.97 0.25 -1.16 1 2 3 4 5 -1.58 1.58 RHAG 0.62 1.17 -0.41 -0.91 -0.05 1 2 3 4 5 -1.58 1.58 LOC388963 1.29 1.07 -0.51 -0.17 -0.40 1 2 3 4 5 -1.58 1.58 HS.583872 -0.31 0.64 -0.94 0.52 3.20 1 2 3 4 5 -1.58 1.58 HS.545699 -0.54 1.03 -0.55 0.58 -0.37 1 2 3 4 5 -1.58 1.58 HS.130343 0.57 1.66 0.08 0.27 -0.32 1 2 3 4 5 -1.58 1.58 HS.145853 -0.11 1.10 -0.48 0.13 0.02 1 2 3 4 5 -1.58 1.58 LOC442206 0.18 0.34 -1.24 2.91 -0.56 1 2 3 4 5 -1.58 1.58 KIAA0754 0.49 0.87 -0.71 2.18 1.82 1 2 3 4 5 -1.58 1.58 HS.564208 1.19 1.73 0.14 0.48 1.92 1 2 3 4 5 -1.59 1.59 HS.473952 2.58 1.19 -0.40 0.68 1.16 1 2 3 4 5 -1.59 1.59 HS.541015 0.34 1.18 -0.41 1.30 1.50 1 2 3 4 5 -1.59 1.59 LOC651403 -0.86 2.12 0.54 -0.51 -0.73 1 2 3 4 5 -1.59 1.59 LOC648794 8.17 0.81 -0.78 0.08 1.17 1 2 3 4 5 -1.59 1.59 LOC652519 -0.11 1.31 -0.28 1.45 0.57 1 2 3 4 5 -1.59 1.59 LOC654032 1.84 0.71 -0.88 5.69 0.32 1 2 3 4 5 -1.59 1.59 LOC149224 0.70 2.04 0.45 -0.47 -0.16 1 2 3 4 5 -1.59 1.59 HS.151444 2.14 1.42 -0.17 0.13 -0.21 1 2 3 4 5 -1.59 1.59 LOC646908 1.32 0.99 -0.60 0.08 0.44 1 2 3 4 5 -1.59 1.59 LOC649185 1.35 1.13 -0.46 0.06 -0.42 1 2 3 4 5 -1.59 1.59 HS.125420 1.24 0.36 -1.24 0.08 -0.84 1 2 3 4 5 -1.59 1.59 LOC392232 -0.58 1.87 0.28 -0.31 -0.09 1 2 3 4 5 -1.59 1.59 HS.572161 0.11 1.16 -0.43 0.30 0.00 1 2 3 4 5 -1.59 1.59 HS.555563 4.08 1.07 -0.52 0.71 4.25 1 2 3 4 5 -1.59 1.59 HS.542219 0.55 1.09 -0.50 2.39 1.59 1 2 3 4 5 -1.59 1.59 LOC642263 -0.97 1.38 -0.22 -0.82 0.01 1 2 3 4 5 -1.59 1.59 LOC392275 0.04 1.40 -0.20 -0.21 -0.16 1 2 3 4 5 -1.59 1.59 OR2 3 0.86 0.95 -0.65 2.55 0.24 1 2 3 4 5 -1.60 1.60 HS.424165 3.26 0.91 -0.69 -0.26 -0.38 1 2 3 4 5 -1.60 1.60 HS.543536 0.55 1.85 0.26 -0.37 0.18 1 2 3 4 5 -1.60 1.60 DCDC1 -1.06 0.78 -0.81 -0.29 -0.38 1 2 3 4 5 -1.60 1.60 FSD1CL -0.37 0.73 -0.87 0.88 -1.03 1 2 3 4 5 -1.60 1.60 KRTAP6-3 -0.57 0.94 -0.65 -0.12 1.44 1 2 3 4 5 -1.60 1.60 Table 3 142 HS.555562 0.01 0.72 -0.88 2.11 -0.43 1 2 3 4 5 -1.60 1.60 HS.131038 1.72 1.42 -0.18 -1.05 -0.59 1 2 3 4 5 -1.60 1.60 HS.578610 1.40 1.43 -0.17 -0.28 -0.18 1 2 3 4 5 -1.60 1.60 LOC650733 1.32 3.12 1.52 -0.20 -0.49 1 2 3 4 5 -1.60 1.60 HS.543552 -0.37 1.03 -0.57 -0.30 -0.08 1 2 3 4 5 -1.60 1.60 CALCB -0.13 1.41 -0.19 1.05 -0.05 1 2 3 4 5 -1.60 1.60 LOC652067 1.34 1.40 -0.20 0.10 0.10 1 2 3 4 5 -1.60 1.60 HS.576646 -0.45 1.81 0.21 2.01 -0.13 1 2 3 4 5 -1.60 1.60 LOC642622 0.33 1.17 -0.43 3.20 0.46 1 2 3 4 5 -1.60 1.60 HS.574023 -0.14 0.74 -0.86 -0.25 1.00 1 2 3 4 5 -1.60 1.60 HS.545895 -0.68 0.76 -0.84 0.91 -0.98 1 2 3 4 5 -1.60 1.60 HS.335010 -0.24 1.54 -0.06 0.09 -0.43 1 2 3 4 5 -1.60 1.60 F9 0.84 1.40 -0.20 0.00 -0.15 1 2 3 4 5 -1.60 1.60 HS.572681 0.16 0.17 -1.43 -0.23 0.08 1 2 3 4 5 -1.60 1.60 HS.539243 -0.07 2.49 0.89 0.22 0.52 1 2 3 4 5 -1.60 1.60 HS.573434 2.35 1.32 -0.28 -0.16 -0.50 1 2 3 4 5 -1.60 1.60 LOC648803 -0.29 1.16 -0.44 -0.08 0.61 1 2 3 4 5 -1.60 1.60 FIGN 0.52 1.22 -0.39 -0.38 1.01 1 2 3 4 5 -1.60 1.60 HS.47390 2.80 1.37 -0.23 -0.28 0.48 1 2 3 4 5 -1.60 1.60 LOC652792 -0.34 1.38 -0.23 0.57 0.01 1 2 3 4 5 -1.61 1.61 HS.530833 0.28 1.77 0.16 0.86 -0.15 1 2 3 4 5 -1.61 1.61 TRPV6 -0.69 1.98 0.37 -0.07 0.48 1 2 3 4 5 -1.61 1.61 LOC643904 3.73 0.40 -1.20 -0.29 -1.06 1 2 3 4 5 -1.61 1.61 CENPI -0.42 0.90 -0.71 -0.07 -0.46 1 2 3 4 5 -1.61 1.61 HS.444858 -0.19 1.52 -0.09 -0.24 -0.21 1 2 3 4 5 -1.61 1.61 HS.582620 -1.15 1.73 0.12 -1.01 1.52 1 2 3 4 5 -1.61 1.61 HS.566638 2.28 1.73 0.12 0.81 0.17 1 2 3 4 5 -1.61 1.61 HS.540790 0.95 0.54 -1.07 2.37 2.61 1 2 3 4 5 -1.61 1.61 ISL1 0.35 0.91 -0.70 -0.45 1.78 1 2 3 4 5 -1.61 1.61 LOC220998 3.10 1.16 -0.45 0.49 0.92 1 2 3 4 5 -1.61 1.61 IGFN1 0.40 2.31 0.70 3.11 -0.88 1 2 3 4 5 -1.61 1.61 C1QL3 -0.14 1.92 0.31 -0.27 0.71 1 2 3 4 5 -1.61 1.61 HS.61881 -0.11 1.47 -0.14 0.16 0.37 1 2 3 4 5 -1.61 1.61 HS.529249 0.01 1.08 -0.53 0.80 0.10 1 2 3 4 5 -1.61 1.61 KRT18 -0.09 1.23 -0.38 0.96 -0.61 1 2 3 4 5 -1.61 1.61 LOC644242 0.05 1.54 -0.07 0.02 -0.12 1 2 3 4 5 -1.61 1.61 LOC645039 2.74 1.28 -0.33 -0.52 -0.37 1 2 3 4 5 -1.61 1.61 LOC387873 0.03 1.11 -0.51 -0.06 0.94 1 2 3 4 5 -1.61 1.61 LOC728160 -0.03 1.37 -0.24 0.66 1.53 1 2 3 4 5 -1.61 1.61 HS.583965 -0.17 1.47 -0.14 0.29 1.91 1 2 3 4 5 -1.61 1.61 C20ORF173 1.55 0.92 -0.69 0.00 0.93 1 2 3 4 5 -1.61 1.61 HS.131427 -0.49 2.29 0.67 1.33 2.38 1 2 3 4 5 -1.61 1.61 HS.563974 0.10 1.58 -0.04 -0.28 0.29 1 2 3 4 5 -1.61 1.61 HS.235050 3.07 1.52 -0.09 -0.25 0.66 1 2 3 4 5 -1.61 1.61 HS.579410 6.65 1.90 0.28 1.96 1.15 1 2 3 4 5 -1.61 1.61 AMBN 4.50 0.60 -1.01 2.36 1.09 1 2 3 4 5 -1.61 1.61 HS.542914 0.74 1.24 -0.37 -0.14 0.15 1 2 3 4 5 -1.62 1.62 SPANXB2 -0.52 1.01 -0.60 -0.45 -0.51 1 2 3 4 5 -1.62 1.62 HS.541724 0.31 0.88 -0.74 1.52 -0.31 1 2 3 4 5 -1.62 1.62 Table 3 143 LOC647337 -0.41 0.95 -0.66 1.92 0.85 1 2 3 4 5 -1.62 1.62 FGF8 0.23 1.40 -0.22 -0.37 1.99 1 2 3 4 5 -1.62 1.62 HS.542837 1.56 1.29 -0.33 0.14 -0.66 1 2 3 4 5 -1.62 1.62 LOC653841 0.27 1.04 -0.58 -0.57 -0.40 1 2 3 4 5 -1.62 1.62 PRM1 1.03 0.85 -0.77 0.60 -0.24 1 2 3 4 5 -1.62 1.62 HS. 126046 -0.76 1.45 -0.17 1.47 0.70 1 2 3 4 5 -1.62 1.62 LOC390856 0.06 0.95 -0.67 -0.23 0.79 1 2 3 4 5 -1.62 1.62 WNK4 5.50 1.62 0.00 -0.07 -0.05 1 2 3 4 5 -1.62 1.62 ZDHHC11B 1.17 1.03 -0.59 -0.70 -0.70 1 2 3 4 5 -1.62 1.62 PRY -0.71 1.70 0.08 -1.07 -0.08 1 2 3 4 5 -1.62 1.62 LOC652582 0.11 1.24 -0.38 0.77 0.42 1 2 3 4 5 -1.62 1.62 HS.583052 1.80 1.99 0.37 -0.89 -1.06 1 2 3 4 5 -1.62 1.62 HS.467837 0.40 1.19 -0.44 0.54 -0.35 1 2 3 4 5 -1.62 1.62 LOC642231 -0.18 1.40 -0.22 -0.56 -0.91 1 2 3 4 5 -1.62 1.62 LOC645322 0.95 1.25 -0.37 0.99 1.19 1 2 3 4 5 -1.62 1.62 HS.565004 1.61 0.72 -0.91 0.11 -0.15 1 2 3 4 5 -1.62 1.62 NME5 1.73 1.68 0.05 -0.73 0.92 1 2 3 4 5 -1.62 1.62 HS.542810 0.43 1.10 -0.52 -0.25 -0.15 1 2 3 4 5 -1.62 1.62 HS.570442 3.99 0.56 -1.06 1.66 -0.73 1 2 3 4 5 -1.62 1.62 PLXNB3 -0.58 1.04 -0.58 0.06 1.84 1 2 3 4 5 -1.62 1.62 HS.563763 0.25 ; 1.82 0.19 0.65 1.05 1 2 3 4 5 -1.62 1.62 SCUBE2 0.84 1.01 -0.62 0.43 0.10 1 2 3 4 5 -1.63 1.63 HS.563306 -0.09; 1.26 -0.37 -0.43 0.18 1 2 3 4 5 -1.63 1.63 P0U4F1 -0.16 1.46 -0.17 -0.27 -0.12 1 2 3 4 5 -1.63 1.63 LOC643107 -0.76 0.60 -1.03 -0.20 -0.14 1 2 3 4 5 -1.63 1.63 HS.214218 -0.08 1.08 -0.55 0.70 0.46 1 2 3 4 5 -1.63 1.63 HS.581377 -0.54 0.95 -0.68 -0.22 -0.12 1 2 3 4 5 -1.63 1.63 CTXN3 -0.97 2.29 0.67 0.47 0.32 1 2 3 4 5 -1.63 1.63 HS.545366 -0.62 0.87 -0.76 -0.47 0.37 1 2 3 4 5 -1.63 1.63 LOC642359 -0.22 0.84 -0.79 1.42 -0.08 1 2 3 4 5 -1.63 1.63 HS.468805 -2.09 0.14 -1.49 -0.02 2.10 1 2 3 4 5 -1.63 1.63 LCN9 0.06 0.81 -0.82 1.66 1.24 1 2 3 4 5 -1.63 1.63 HS.569684 -0.41 1.11 -0.52 1.01 -0.45 1 2 3 4 5 -1.63 1.63 LOC402100 0.97 3.57 1.94 -0.55 2.90 1 2 3 4 5 -1.63 1.63 HS.544392 -0.39 1.49 -0.15 -0.79 -0.28 1 2 3 4 5 -1.63 1.63 HS.584721 0.24 1.03 -0.61 0.73 -0.34 1 2 3 4 5 -1.63 1.63 ARID1B 0.52 1.42 -0.22 -0.04 0.17 1 2 3 4 5 -1.63 1.63 HS.544997 -0.68 0.70 -0.93 -1.31 -0.84 1 2 3 4 5 -1.63 1.63 HS.566242 -0.45 1.77 0.14 -0.43 -0.88 1 2 3 4 5 -1.63 1.63 HS.552287 0.08 1.59 -0.04 -0.20 1.06 1 2 3 4 5 -1.63 1.63 HS.515725 -0.60 1.30 -0.33 0.06 0.44 1 2 3 4 5 -1.63 1.63 LOC648262 -0.55 1.61 -0.02 -0.86 0.23 1 2 3 4 5 -1.64 1.64 HS.578069 0.58 1.28 -0.35 -0.57 -0.59 1 2 3 4 5 -1.64 1.64 HS.564933 0.30 1.26 -0.38 0.03 0.77 1 2 3 4 5 -1.64 1.64 LOC391730 3.00 1.47 -0.17 0.47 0.90 1 2 3 4 5 -1.64 1.64 HS.572124 0.03 1.49 -0.14 0.02 0.10 1 2 3 4 5 -1.64 1.64 HS.250453 0.57 1.21 -0.42 1.44 -0.30 1 2 3 4 5 -1.64 1.64 HS.23560 -0.18 1.35 -0.29 -0.19 -0.45 1 2 3 4 5 -1.64 1.64 HS.97639 -1.28 1.30 -0.34 0.43 -0.03 1 2 3 4 5 -1.64 1.64 Table 3 144 HS.207543 0.57 2.45 0.81 0.83 0.50 1 2 3 4 5 -1.64 1.64 ANKK1 -0.19 1.32 -0.32 -0.08 -0.46 1 2 3 4 5 -1.64 1.64 HS.554056 0.57 1.96 0.32 0.60 0.27 1 2 3 4 5 -1.64 1.64 LOC650475 0.19 1.34 -0.30 -0.23 -0.27 1 2 3 4 5 -1.64 1.64 HS.554642 -0.07 1.48 -0.16 0.69 -0.14 1 2 3 4 5 -1.64 1.64 RANBP17 -0.24 1.17 -0.47 0.78 -1.36 1 2 3 4 5 -1.64 1.64 HS.562571 -0.96 2.20 0.56 -0.81 -0.34 1 2 3 4 5 -1.64 1.64 PLUNC -0.11 3.94 2.30 -0.57 0.38 1 2 3 4 5 -1.64 1.64 HS.543131 0.05 1.35 -0.29 0.04 0.87 1 2 3 4 5 -1.64 1.64 HS.566874 3.69 4.47 2.83 2.29 -0.87 1 2 3 4 5 -1.64 1.64 HS.529669 -1.08 0.83 -0.81 0.61 -1.19 1 2 3 4 5 -1.64 1.64 ZNF704 -0.18 1.18 -0.47 0.97 0.26 1 2 3 4 5 -1.64 1.64 HS.542758 1.08 0.99 -0.65 -1.03 -0.53 1 2 3 4 5 -1.64 1.64 HS.223583 -0.30 1.17 -0.48 -0.03 -0.62 1 2 3 4 5 -1.64 1.64 DNAJC5B 4.72 1.06 -0.58 -0.81 -0.97 1 2 3 4 5 -1.65 1.65 HS.567044 -0.04 1.47 -0.18 -0.21 1.36 1 2 3 4 5 -1.65 1.65 HS.543895 -0.33 1.31 -0.33 -0.13 0.89 1 2 3 4 5 -1.65 1.65 HS.571649 1.46 1.64 0.00 -0.40 -0.84 1 2 3 4 5 -1.65 1.65 HS.538029 0.43 2.47 0.83 0.74 0.64 1 2 3 4 5 -1.65 1.65 HS.157382 -0.15 1.40 -0.25 -0.01 0.28 1 2 3 4 5 -1.65 1.65 TMEM35 -0.04^ 1.43 -0.21 0.38 0.04 1 2 3 4 5 -1.65 1.65 HS.545890 2.42 0.99 -0.66 0.91 0.55 1 2 3 4 5 -1.65 1.65 HS.573795 0.15 0.99 -0.66 -0.45 -0.39 1 2 3 4 5 -1.65 1.65 SLC36A3 1.30 0.97 -0.68 0.46 -0.59 1 2 3 4 5 -1.65 1.65 HS.132373 0.41 1.40 -0.25 -0.68 -0.38 1 2 3 4 5 -1.65 1.65 CCDC64 0.49 2.03 0.38 -0.49 0.24 1 2 3 4 5 -1.65 1.65 HS.149828 0.96 2.33 0.68 -0.25 0.24 1 2 3 4 5 -1.65 1.65 HS.208513 0.09 1.04 -0.61 -0.67 -0.82 1 2 3 4 5 -1.65 1.65 HS.563866 1.13 1.33 -0.32 0.08 -0.23 1 2 3 4 5 -1.65 1.65 HS.551390 -0.70 2.47 0.82 -1.19 -0.88 1 2 3 4 5 -1.65 1.65 UNQ9438 -0.47 1.19 -0.47 1.27 0.41 1 2 3 4 5 -1.65 1.65 OSTN -0.94 0.58 -1.07 0.47 0.76 1 2 3 4 5 -1.65 1.65 LARP6 0.28 1.41 -0.25 0.64 0.04 1 2 3 4 5 -1.65 1.65 TEX14 -0.64 0.73 -0.93 -0.28 -0.61 1 2 3 4 5 -1.66 1.66 HS.257891 -0.24 1.44 -0.22 0.52 -0.26 1 2 3 4 5 -1.66 1.66 LOC727849 -0.57 1.17 -0.49 2.41 -0.04 1 2 3 4 5 -1.66 1.66 CNGA2 0.10 0.80 -0.86 0.28 -0.82 1 2 3 4 5 -1.66 1.66 LOC648576 -0.15 0.98 -0.68 0.90 1.10 1 2 3 4 5 -1.66 1.66 ASAM -0.12 1.05 -0.61 -0.11 0.42 1 2 3 4 5 -1.66 1.66 KLHDC1 -0.18 1.96 0.30 0.07 -0.05 1 2 3 4 5 -1.66 1.66 LOC648878 0.78 1.80 0.14 -0.06 0.55 1 2 3 4 5 -1.66 1.66 HS.571398 -0.60 1.30 -0.36 -0.23 -0.25 1 2 3 4 5 -1.66 1.66 HS.566754 -0.92 0.93 -0.73 2.28 -0.17 1 2 3 4 5 -1.66 1.66 HS.575543 0.00 1.57 -0.09 0.00 1.23 1 2 3 4 5 -1.66 1.66 FAM55A -1.28 1.57 -0.10 0.68 -0.94 1 2 3 4 5 -1.67 1.67 LOC648609 0.85 2.15 0.48 -0.23 -0.35 1 2 3 4 5 -1.67 1.67 LOC728056 0.23 0.90 -0.77 0.22 -0.57 1 2 3 4 5 -1.67 1.67 SH3GL2 1.87 1.75 0.08 0.02 1.13 1 2 3 4 5 -1.67 1.67 HS.441201 0.49 1.46 -0.21 0.62 0.14 1 2 3 4 5 -1.67 1.67 Table 3 145 WSCD2 -0.24 1.83 0.16 -0.08 -0.21 1 2 3 4 5 -1.67 1.67 LOC646350 1.11 1.68 0.00 0.83 1.20 1 2 3 4 5 -1.67 1.67 HS.447853 -0.24 2.33 0.66 -0.86 1.43 1 2 3 4 5 -1.67 1.67 LOC388335 0.19 1.63 -0.05 0.20 0.23 1 2 3 4 5 -1.67 1.67 HS.582872 -0.48 1.38 -0.29 0.08 -0.28 1 2 3 4 5 -1.67 1.67 GADL1 0.14 0.58 -1.10 -1.36 -1.40 1 2 3 4 5 -1.67 1.67 LOC341651 1.85 0.88 -0.80 1.86 0.42 1 2 3 4 5 -1.67 1.67 HS.583659 -0.61 1.48 -0.19 -0.24 1.04 1 2 3 4 5 -1.67 1.67 HS.553318 0.66 1.71 0.03 0.97 -0.35 1 2 3 4 5 -1.67 1.67 HS.581599 0.20 1.71 0.03 0.28 0.73 1 2 3 4 5 -1.67 1.67 HS.128285 1.03 1.20 -0.47 -0.32 2.33 1 2 3 4 5 -1.68 1.68 LOC441340 -0.15 2.04 0.36 1.76 -0.23 1 2 3 4 5 -1.68 1.68 HS.540354 -0.02 1.28 -0.39 -0.18 2.74 1 2 3 4 5 -1.68 1.68 HS.564017 -0.55 1.21 -0.47 -0.60 2.11 1 2 3 4 5 -1.68 1.68 HS.566146 0.61 1.40 -0.28 0.14 -0.09 1 2 3 4 5 -1.68 1.68 C16ORF50 0.59 1.03 -0.65 -1.00 -0.84 1 2 3 4 5 -1.68 1.68 HS.159853 -0.26 1.37 -0.31 3.89 -0.53 1 2 3 4 5 -1.68 1.68 LOC646447 -0.02 1.37 -0.32 -0.37 -0.08 1 2 3 4 5 -1.68 1.68 LOC645438 -0.31 1.70 0.02 -0.49 1.00 1 2 3 4 5 -1.68 1.68 HS.282848 1.36 1.84 0.16 0.29 0.74 1 2 3 4 5 -1.68 1.68 HS.160568 -0.53 2.64 0.96 2.54 -0.07 1 2 3 4 5 -1.68 1.68 HS.576294 1.71 1.85 0.17 1.28 -0.06 1 2 3 4 5 -1.68 1.68 HS.582729 1.01 1.26 -0.42 0.23 -0.24 1 2 3 4 5 -1.68 1.68 HS.435344 -0.49 1.52 -0.17 -0.35 -0.01 1 2 3 4 5 -1.69 1.69 LOC653789 -0.38 1.83 0.14 0.23 -0.19 1 2 3 4 5 -1.69 1.69 LOC653089 0.84 1.12 -0.57 -0.39 -0.58 1 2 3 4 5 -1.69 1.69 LOC645876 4.17 0.48 -1.20 1.33 4.19 1 2 3 4 5 -1.69 1.69 LOC401351 0.12 1.15 -0.54 0.53 0.72 1 2 3 4 5 -1.69 1.69 HS.502133 1.84 1.01 -0.67 0.58 0.27 1 2 3 4 5 -1.69 1.69 C60RF15 -0.62 1.76 0.07 1.47 -0.41 1 2 3 4 5 -1.69 1.69 HS.546113 0.28 1.01 -0.68 0.23 0.27 1 2 3 4 5 -1.69 1.69 HS.577338 -0.01 1.87 0.18 0.19 0.18 1 2 3 4 5 -1.69 1.69 HS.551019 0.85 -0.61 -2.30 0.29 2.71 1 2 3 4 5 -1.69 1.69 HS.576580 -0.27 1.40 -0.29 -0.61 0.04 1 2 3 4 5 -1.69 1.69 HS.218030 -0.14 1.68 -0.01 1.63 -0.04 1 2 3 4 5 -1.69 1.69 HS.551335 -0.10 1.22 -0.47 0.69 0.84 1 2 3 4 5 -1.69 1.69 HS.576874 0.46 1.15 -0.54 -0.49 -0.36 1 2 3 4 5 -1.69 1.69 HS.162727 -0.10 2.72 1.03 1.82 0.22 1 2 3 4 5 -1.69 1.69 HS.122403 1.62 0.78 -0.91 -0.28 -1.66 1 2 3 4 5 -1.69 1.69 LOC400793 -0.27 2.45 0.75 -0.45 -0.62 1 2 3 4 5 -1.69 1.69 HS.542562 -0.02 1.39 -0.30 -0.56 -0.77 1 2 3 4 5 -1.69 1.69 VSTM2 -0.35 1.58 -0.11 -0.43 0.22 1 2 3 4 5 -1.70 1.70 HS.282861 -0.12 1.65 -0.04 1.50 -0.46 1 2 3 4 5 -1.70 1.70 LOC644567 -1.24 0.53 -1.16 -0.26 -0.03 1 2 3 4 5 -1.70 1.70 HS.569932 0.29 0.26 -1.44 -0.77 3.35 1 2 3 4 5 -1.70 1.70 LOC644133 -0.01 1.54 -0.15 0.05 -0.22 1 2 3 4 5 -1.70 1.70 HS.566547 0.54 1.25 -0.45 -0.18 -0.88 1 2 3 4 5 -1.70 1.70 OSGIN1 -0.46 1.36 -0.34 0.54 -0.50 1 2 3 4 5 -1.70 1.70 HS.582980 -1.13 1.19 -0.50 -1.07 0.59 1 2 3 4 5 -1.70 1.70 Table 3 146 HSPB7 -0.66 1.05 -0.64 1.45 -0.13 1 2 3 4 5 -1.70 1.70 HS.566795 0.72 1.39 -0.31 -0.67 0.16 1 2 3 4 5 -1.70 1.70 LOC149069 1.28 0.67 -1.02 0.97 0.77 1 2 3 4 5 -1.70 1.70 HS.543872 1.22 1.68 -0.02 0.18 0.27 1 2 3 4 5 -1.70 1.70 HS.500668 1.04 1.63 -0.07 -0.50 0.96 1 2 3 4 5 -1.70 1.70 OR5D13 -0.29 1.13 -0.57 -0.15 0.85 1 2 3 4 5 -1.70 1.70 LOC647661 0.99 1.06 -0.64 -0.41 -0.22 1 2 3 4 5 -1.70 1.70 TRIM42 -0.09 1.24 -0.46 0.61 -0.21 1 2 3 4 5 -1.70 1.70 LOC641964 -0.17 1.58 -0.12 -0.03 -0.08 1 2 3 4 5 -1.70 1.70 GPR98 -0.87 0.13 -1.57 1.76 -0.82 1 2 3 4 5 -1.70 1.70 TMEM92 1.30 2.06 0.36 0.02 -0.89 1 2 3 4 5 -1.70 1.70 HS.547712 -0.69 0.90 -0.80 -0.07 1.39 1 2 3 4 5 -1.70 1.70 CLCA2 1.12 1.12 -0.58 1.08 0.98 1 2 3 4 5 -1.70 1.70 C10RF146 -0.60 1.11 -0.59 0.15 0.88 1 2 3 4 5 -1.70 1.70 HS.570365 0.97 1.30 -0.41 0.12 3.14 1 2 3 4 5 -1.70 1.70 HS.552094 -0.90 0.55 -1.15 0.53 -0.23 1 2 3 4 5 -1.70 1.70 LOC728343 0.39 1.60 -0.10 0.39 0.70 1 2 3 4 5 -1.70 1.70 HS.541039 -0.01 2.22 0.52 0.48 0.52 1 2 3 4 5 -1.70 1.70 HS.97763 -0.20 1.38 -0.32 1.99 0.23 1 2 3 4 5 -1.70 1.70 LOC643770 -0.59 2.65 0.94 0.73 -0.69 1 2 3 4 5 -1.71 1.71 HS.552545 -0.01 1.77 0.07 0.96 1.06 1 2 3 4 5 -1.71 1.71 KIAA1202 0.97 4.91 3.21 -1.03 0.44 1 2 3 4 5 -1.71 1.71 HS.298228 -0.09 0.42 -1.29 -0.11 2.13 1 2 3 4 5 -1.71 1.71 HS.278098 -0.42 1.49 -0.22 0.59 0.41 1 2 3 4 5 -1.71 1.71 USP44 -0.05 1.63 -0.08 -0.08 -0.05 1 2 3 4 5 -1.71 1.71 HS.148771 -0.33 0.80 -0.91 -0.37 -0.31 1 2 3 4 5 -1.71 1.71 LOC649659 2.05 1.17 -0.54 0.82 0.83 1 2 3 4 5 -1.71 1.71 HS.544562 0.21 1.19 -0.52 -0.53 0.28 1 2 3 4 5 -1.71 1.71 STOX1 -0.12 1.67 -0.04 0.03 0.13 1 2 3 4 5 -1.71 1.71 LOC646699 -0.38 2.38 0.67 -0.05 1.04 1 2 3 4 5 -1.71 1.71 HS.346489 0.01 1.55 -0.16 0.84 1.31 1 2 3 4 5 -1.71 1.71 LOC643344 1.72 2.33 0.62 1.86 3.24 1 2 3 4 5 -1.71 1.71 LOC642974 3.37 1.32 -0.40 1.40 -0.26 1 2 3 4 5 -1.72 1.72 LOC653211 -0.10 1.65 -0.06 -0.15 -0.03 1 2 3 4 5 -1.72 1.72 LOC651821 -0.04 1.31 -0.41 -0.03 -0.20 1 2 3 4 5 -1.72 1.72 ZFHX2 -0.59 1.42 -0.30 -0.76 -0.76 1 2 3 4 5 -1.72 1.72 HS.446328 1.16 1.02 -0.70 1.29 -0.07 1 2 3 4 5 -1.72 1.72 HS.566468 1.21 2.72 1.00 0.61 0.84 1 2 3 4 5 -1.72 1.72 HS.538015 2.07 1.84 0.12 0.04 -0.14 1 2 3 4 5 -1.72 1.72 HS.191637 0.51 1.15 -0.57 0.96 2.72 1 2 3 4 5 -1.72 1.72 M PI O -0.77 1.42 -0.30 2.12 0.06 1 2 3 4 5 -1.72 1.72 EPO 0.21 1.81 0.09 -0.80 -0.91 1 2 3 4 5 -1.72 1.72 METTL7B 0.41 2.58 0.86 0.88 -0.06 1 2 3 4 5 -1.72 1.72 HS.575126 -0.63 0.98 -0.74 2.46 -0.91 1 2 3 4 5 -1.72 1.72 LOC646569 2.07 0.55 -1.17 2.32 1.42 1 2 3 4 5 -1.72 1.72 HS.565752 6.99 0.48 -1.24 -2.32 -2.49 1 2 3 4 5 -1.72 1.72 HS.574762 0.58 0.70 -1.02 0.00 0.99 1 2 3 4 5 -1.72 1.72 LOC650076 -0.10 1.27 -0.45 -0.69 0.15 1 2 3 4 5 -1.72 1.72 HS.567153 -0.13 1.34 -0.39 -0.21 0.18 1 2 3 4 5 -1.73 1.73 Table 3 147 HS.118769 6.57 1.28 -0.44 0.19 0.67 1 2 3 4 5 -1.73 1.73 HS.71657 2.93 1.36 -0.37 -0.19 -0.02 1 2 3 4 5 -1.73 1.73 K T4 -0.02 1.11 -0.61 0.76 3.78 1 2 3 4 5 -1.73 1.73 HS.544104 0.95 2.42 0.70 3.21 1.23 1 2 3 4 5 -1.73 1.73 LOC653803 0.97 1.65 -0.07 -0.04 0.02 1 2 3 4 5 -1.73 1.73 LOC641697 0.02 1.59 -0.14 0.61 0.33 1 2 3 4 5 -1.73 1.73 HS.150688 1.98 2.02 0.29 -1.30 0.08 1 2 3 4 5 -1.73 1.73 HS.122034 -0.34 0.85 -0.88 0.26 0.08 1 2 3 4 5 -1.73 1.73 LOC732391 0.15 2.31 0.58 -0.10 -0.50 1 2 3 4 5 -1.73 1.73 HS.552078 1.77 1.34 -0.39 2.72 -0.19 1 2 3 4 5 -1.73 1.73 HS.55401O 0.06 1.04 -0.69 -0.34 -0.36 1 2 3 4 5 -1.73 1.73 HS.562559 0.14 1.15 -0.59 -0.18 0.62 1 2 3 4 5 -1.73 1.73 HS.48501 -0.03 0.77 -0.96 -0.64 -0.59 1 2 3 4 5 -1.73 1.73 HS.582706 1.34 1.45 -0.28 0.18 -0.18 1 2 3 4 5 -1.73 1.73 HIST3H3 -0.29 1.44 -0.29 0.83 0.12 1 2 3 4 5 -1.73 1.73 HS.245028 0.82 1.67 -0.06 1.36 -0.55 1 2 3 4 5 -1.73 1.73 Aug-10 0.58 2.78 1.04 0.15 0.82 1 2 3 4 5 -1.74 1.74 SLC10A1 -0.18 1.32 -0.42 -0.65 0.26 1 2 3 4 5 -1.74 1.74 HS.389223 0.05 1.91 0.17 -0.90 0.21 1 2 3 4 5 -1.74 1.74 HS.382696 0.57 1.67 -0.07 0.99 -0.86 1 2 3 4 5 -1.74 1.74 HS.116129 4.13 1.08 -0.66 0.13 0.29 1 2 3 4 5 -1.74 1.74 HS.202189 0.59 0.95 -0.79 0.76 -0.41 1 2 3 4 5 -1.74 1.74 LOC652793 -0.29 1.70 -0.04 0.82 3.13 1 2 3 4 -1.74 1.74 GBA3 -0.39 2.04 0.31 -0.18 -0.23 1 2 3 4 5 -1.74 1.74 LOC649389 -0.40 1.48 -0.26 0.80 0.20 1 2 3 4 5 -1.74 1.74 LOC652148 0.38 0.88 -0.86 -0.65 -0.55 1 2 3 4 5 -1.74 1.74 HS.576444 -0.46 1.59 -0.15 -0.10 -0.21 1 2 3 4 5 -1.74 1.74 CALML3 -0.18 1.58 -0.16 0.22 -0.32 1 2 3 4 5 -1.74 1.74 LOC642863 0.42 0.96 -0.79 -0.05 -0.15 1 2 3 4 5 -1.74 1.74 HS.563201 1.99 2.77 1.03 1.87 0.14 1 2 3 4 5 . -1.75 1.75 HS.99298 0.89 1.36 -0.39 3.42 -0.64 1 2 3 4 5 -1.75 1.75 HS.191073 4.64 1.65 -0.10 2.44 -0.65 1 2 3 4 5 -1.75 1.75 LOC390211 0.97 2.72 0.98 0.55 -0.22 1 2 3 4 5 -1.75 1.75 RNF138P1 4.55 1.47 -0.27 -0.77 0.01 1 2 3 4 5 -1.75 1.75 C90RF152 -0.84 0.72 -1.03 1.92 -0.71 1 2 3 4 5 -1.75 1.75 LOC652000 -1.44 1.83 0.08 0.54 -1.43 1 2 3 4 5 -1.75 1.75 HS.566765 0.33 1.41 -0.34 1.18 -0.20 1 2 3 4 5 -1.75 1.75 HS.505141 -0.26 1.99 0.24 1.06 1.14 1 2 3 4 5 -1.75 1.75 HS.105423 0.96 1.17 -0.58 -0.97 0.91 1 2 3 4 5 -1.75 1.75 SDK1 0.32 1.79 0.04 1.10 0.98 1 2 3 4 5 -1.75 1.75 CNTN2 0.42 3.35 1.60 0.25 0.82 1 2 3 4 5 -1.75 1.75 CAPZA3 3.34 4.25 2.50 2.01 3.70 1 2 3 4 5 -1.75 1.75 HS.577647 -0.68 1.56 -0.19 -0.13 3.34 1 2 3 4 5 -1.75 1.75 HS.539118 -0.07 1.78 0.02 -0.48 -0.59 1 2 3 4 5 -1.75 1.75 TWIST2 0.11 1.56 -0.19 0.23 0.45 1 2 3 4 5 -1.75 1.75 GSG2 0.09 1.32 -0.43 1.70 -0.56 1 2 3 4 5 -1.75 1.75 TFCP2L1 -0.30 1.42 -0.33 -0.54 -0.20 1 2 3 4 5 -1.75 1.75 HS.581313 1.54 1.42 -0.34 1.04 -0.27 1 2 3 4 5 -1.75 1.75 HS.538491 0.29 1.33 -0.42 1.78 0.02 1 2 3 4 5 -1.76 1.76 Table 3 148 FU42953 0.15 1.69 -0.07 0.35 -0.08 1 2 3 4 5 -1.76 1.76 TMEM89 -0.05 1.62 -0.13 0.04 -0.07 1 2 3 4 5 -1.76 1.76 PCDHGB3 -0.81 1.34 -0.41 -0.57 0.52 1 2 3 4 5 -1.76; 1.76 C1ORF106 0.01 2.44 0.68 0.86 -0.74 1 2 3 4 5 -1.76 1.76 DKK2 0.64 1.69 -0.06 -0.44 2.65 1 2 3 4 5 -1.76 1.76 ATP2C2 -0.49 3.48 1.72 0.52 1.01 1 2 3 4 5 -1.76 1.76 LOC651116 2.92 1.53 -0.22 0.27 0.41 1 2 3 4 5 -1.76 1.76 LOC653057 -0.56 1.87 0.11 0.81 0.00 1 2 3 4 5 -1.76 1.76 HS.561108 1.10 1.76 0.00 -0.10 -0.17 1 2 3 4 5 -1.76 1.76 HS.26580 0.42 2.28 0.52 0.91 -0.78 1 2 3 4 5 -1.76 1.76 LOC727937 0.17 1.60 -0.16 0.17 0.02 1 2 3 4 5 -1.76 1.76 WDR93 0.37 0.94 -0.82 0.30 3.40 1 2 3 4 5 -1.76 1.76 HS.516048 -0.47 2.17 0.41 -0.35 0.67 1 2 3 4 5 -1.76 1.76 CLDN22 2.24 1.39 -0.37 0.36 1.01 1 2 3 4 5 -1.76 1.76 LOC651012 0.80 0.53 -1.23 0.37 -0.04 1 2 3 4 5 -1.76 1.76 ACCN1 -0.48 1.59 -0.17 -0.19 -0.19 1 2 3 4 5 -1.76 1.76 HS.481242 -0.35 1.42 -0.35 1.83 0.16 1 2 3 4 5 -1.76 1.76 HS.131229 1.95 1.52 -0.24 -0.72 -0.56 1 2 3 4 5 -1.76 1.76 HS.535689 6.62 1.49 -0.28 1.70 1.32 1 2 3 4 5 -1.76 1.76 HS.193273 -1.11 0.95 -0.81 1.40 -1.00 1 2 3 4 5 -1.76 1.76 HS.565657 0.18 2.05 0.29 0.61 0.45 1 2 3 4 5 -1.76 1.76 MS4A3 -0.57 1.13 -0.64 -0.48 -0.45 1 2 3 4 5 -1.76 1.76 LOC643132 -0.55 1.46 -0.31 -0.28 -0.19 1 2 3 4 5 -1.77 1.77 HS.560993 -0.57 0.55 -1.22 -0.59 -0.33 1 2 3 4 5 -1.77 1.77 HS.565557 4.15 0.82 -0.95 1.42 3.20 1 2 3 4 5 -1.77 1.77 LOC390595 0.30 3.14 1.37 0.68 0.47 1 2 3 4 5 -1.77 1.77 EPHA3 0.38 1.44 -0.33 -0.69 -0.07 1 2 3 4 5 -1.77 1.77 HS.209165 -0.20 1.37 -0.40 0.43 -0.27 1 2 3 4 5 -1.77 1.77 HS.528223 -0.03 2.04 0.27 0.15 -0.26 1 2 3 4 5 -1.77 1.77 LOC643930 -1.23 1.18 -0.59 -0.63 1.64 1 2 3 4 5 -1.77 1.77 ZNF774 -0.41 1.03 -0.74 -1.26 -0.09 1 2 3 4 5 -1.77 1.77 HS.352682 0.15 1.28 -0.49 0.36 0.70 1 2 3 4 5 -1.77 1.77 HS.540972 0.89 1.69 -0.08 0.04 0.46 1 2 3 4 5 -1.78 1.78 HS.577424 0.15 1.19 -0.59 1.54 0.22 1 2 3 4 5 -1.78 1.78 HS.208128 0.68 1.44 -0.34 -0.09 -0.05 1 2 3 4 5 -1.78 1.78 LOC644628 1.18 1.53 -0.25 -0.46 0.25 1 2 3 4 5 -1.78 1.78 HS.469510 1.03 2.53 0.75 -1.09 -0.08 1 2 3 4 5 -1.78 1.78 HS.563696 1.74 1.30 -0.48 -0.59 -0.36 1 2 3 4 5 -1.78 1.78 LOC728103 -0.94 1.37 -0.41 -1.41 -0.01 1 2 3 4 5 -1.78 1.78 HS.552289 0.95 1.49 -0.29 -0.72 -0.50 1 2 3 4 5 -1.78 1.78 HS.148933 -0.24 2.06 0.27 -0.08 0.02 1 2 3 4 5 -1.78 1.78 HS:581114 -0.33 1.82 0.04 -0.38 0.37 1 2 3 4 5 -1.78 1.78 TRPM3 0.09 2.03 0.25 0.19 1.03 1 2 3 4 5 -1.78 1.78 HS.575260 -0.37 1.34 -0.45 -0.22 0.44 1 2 3 4 5 -1.78 1.78 HS.249709 0.56 0.08 -1.70 0.52 0.23 1 2 3 4 5 -1.78 1.78 HS.336198 0.23 1.45 -0.34 1.13 0.50 1 2 3 4 5 -1.78 1.78 NXF2B -0.26 2.60 0.82 -0.45 -0.41 1 2 3 4 5 -1.78 1.78 HS.434940 -0.71 1.10 -0.69 3.71 -1.20 1 2 3 4 5 -1.78 1.78 HS.566629 3.84 2.29 0.51 -0.08 0.42 1 2 3 4 5 -1.78 1.78 Table 3 149 HS.545543 1.87 0.81 -0.98 -1.22 0.86 1 2 3 4 5 -1.79' 1.79 HS.555388 1.59 2.27 0.48 -0.17 0.32 1 2 3 4 5 -1.79 1.79 PITX3 1.82 1.31 -0.48 1.09 -0.46 1 2 3 4 5 -1.79 1.79 HS.560070 -0.22 1.63 -0.16 -0.01 -0.22 1 2 3 4 5 -1.79 1.79 LOC644023 -0.12 1.84 0.05 0.28 0.13 1 2 3 4 5 -1.79 1.79 HS.156241 -0.43 3.04 1.25 1.08 0.31 1 2 3 4 5 -1.79 1.79 HS.545629 0.53 1.09 -0.71 0.01 0.57 1 2 3 4 5 -1.79 1.79 HS.572021 -0.54 0.99 -0.81 1.15 0.74 1 2 3 4 5 -1.79 1.79 HS.196469 -0.46 2.26 0.47 -0.30 0.00 1 2 3 4 5 -1.79 1.79 HS.541669 2.40 1.16 -0.63 0.52 0.69 1 2 3 4 5 -1.79 1.79 HS.566933 1.39 0.53 -1.26 1.76 3.21 1 2 3 4 5 -1.79 1.79 ST A8 0.40 1.12 -0.68 -0.20 -0.80 1 2 3 4 5 -1.80 1.80 LOC653252 0.15 1.70 -0.10 0.12 1.98 1 2 3 4 5 -1.80 1.80 LOC641785 0.86 1.39 -0.40 0.08 1.13 1 2 3 4 5 -1.80 1.80 HS.576163 -0.49 2.54 0.74 -0.84 1.93 1 2 3 4 5 -1.80 1.80 HS.545184 5.63 1.67 -0.13 -0.68 -1.11 1 2 3 4 5 -1.80 1.80 IL17RD -0.14 1.27 -0.53 1.68 0.66 1 2 3 4 5 -1.80 1.80 HS.129851 -0.06: 1.29 -0.51 -0.33 -0.51 1 2 3 4 5 -1.80 1.80 VASN -0.53 1.56 -0.24 -0.36 -0.02 1 2 3 4 5 -1.80 1.80 OR4D5 0.13 1.12 -0.68 -0.60 0.21 1 2 3 4 5 -1.80 1.80 HS.106554 0.99 1.64 -0.16 4.07 3.20 1 2 3 4 5 -1.80 1.80 LOC652745 2.82 1.03 -0.77 0.32 0.78 1 2 3 4 5 -1.80 1.80 NOS1AP -0.66 0.90 -0.90 0.46 -0.21 1 2 3 4 5 -1.80 1.80 HS.567124 -0.56 1.84 0.04 4.90 -0.02 1 2 3 4 5 -1.80 1.80 C20RF57 -0.39 1.43 -0.38 -0.29 0.46 1 2 3 4 5 -1.80 1.80 LOC643684 0.27 1.48 -0.33 0.35 0.99 1 2 3 4 5 -1.80 1.80 LOC643377 -0.55 0.89 -0.92 1.44 0.16 1 2 3 4 5 -1.81 1.81 HS.580189 2.31 1.07 -0.73 -0.02 0.02 1 2 3 4 5 -1.81 1.81 ASB15 -0.15 1.28 -0.52 0.71 0.51 1 2 3 4 5 -1.81 1.81 GR 3 0.08 1.09 -0.71 0.10 -1.08 1 2 3 4 5 -1.81 1.81 LOC440570 -0.01 4.31 2.50 -0.02 -0.49 1 2 3 4 5 -1.81 1.81 APOA4 -0.37 1.90 0.09 -0.82 -0.14 1 2 3 4 5 -1.81 1.81 HS.569261 0.72 0.52 -1.29 -0.28 -1.36 1 2 3 4 5 -1.81 1.81 HS.363303 0.67 2.57 0.76 0.27 -0.72 1 2 3 4 5 -1.81 1.81 HS.537828 1.82 1.52 -0.29 0.58 -0.35 1 2 3 4 5 -1.81 1.81 HS.443239 1.47 1.30 -0.52 0.32 1.78 1 2 3 4 5 -1.81 1.81 LOC347411 2.57 1.84 0.02 -0.44 -0.42 1 2 3 4 5 -1.81 1.81 HS.576067 -0.12 2.03 0.22 0.03 -0.10 1 2 3 4 5 -1.81 1.81 LOC729675 0.26 1.62 -0.19 -0.22 -0.22 1 2 3 4 5 -1.81 1.81 HS.544013 3.89 0.51 -1.31 -0.73 0.94 1 2 3 4 5 -1.81 1.81 LOC647034 1.36 2.05 0.24 -0.78 -0.65 1 2 3 4 5 -1.81 1.81 LOC646407 1.38 1.57 -0.24 0.13 0.62 1 2 3 4 5 -1.81 1.81 HS.578072 -0.48 1.48 -0.33 0.20 -0.13 1 2 3 4 5 -1.81 1.81 TNXB 0.41 1.26 -0.56 -0.72 -0.41 1 2 3 4 5 -1.82 1.82 MRO 0.05 1.59 -0.23 0.26 3.54 1 2 3 4 5 -1.82 1.82 HS.539339 -0.51 2.25 0.44 0.40 -0.04 1 2 3 4 5 -1.82 1.82 HS.436369 0.01 0.65 -1.17 -0.34 0.21 1 2 3 4 5 -1.82 1.82 HS.542144 0.06 1.20 -0.62 1.28 -0.02 1 2 3 4 5 -1.82 1.82 HS.566968 -0.23 0.99 -0.82 -0.34 -0.69 1 2 3 4 5 -1.82 1.82 Table 3 150 HS.582112 2.13 1.62 -0.19 0.19 1.37 1 2 3 4 5 -1.82 1.82 HS.46473 -0.11 2.21 0.39 0.09 -0.06 1 2 3 4 5 -1.82 1.82 HS.284492 0.00 1.48 -0.34 0.17 -0.40 1 2 3 4 5 -1.82 1.82 LOC651675 -0.39 1.21 -0.61 2.64 -0.49 1 2 3 4 5 -1.82 1.82 HS.301296 1.21 2.12 0.30 5.60 1.43 1 2 3 4 5 -1.82 1.82 LOC643581 0.51 1.59 -0.23 -0.08 -0.26 1 2 3 4 5 -1.82 1.82 SLC30A2 -0.35 0.63 -1.19 0.99 -0.47 1 2 3 4 5 -1.82 1.82 LOC653692 -0.26 1.92 0.10 0.56 1.27 1 2 3 4 5 -1.82 1.82 HS.254485 -0.10 1.23 -0.59 1.40 0.66 1 2 3 4 5 -1.82 1.82 HS.135690 0.05 1.75 -0.07 -0.11 0.79 1 2 3 4 5 -1.82 1.82 HS.542185 4.87 2.16 0.34 -0.18 0.25 1 2 3 4 5 -1.82 1.82 HS.564109 -0.66 1.49 -0.33 0.94 1.34 1 2 3 4 5 -1.82 1.82 HS.562901 4.59 1.51 -0.31 3.93 0.62 1 2 3 4 5 -1.82 1.82 FU34870 -1.01 1.04 -0.78 1.21 -1.17 1 2 3 4 5 -1.82 1.82 LRRTM1 1.15 1.73 -0.09 0.47 1.94 1 2 3 4 5 -1.82 1.82 HS.132920 -0.23 1.31 -0.51 0.37 0.24 1 2 3 4 5 -1.82 1.82 RBMY1A1 6.70 1.41 -0.41 6.55 0.36 1 2 3 4 5 -1.83 1.83 HS.544700 0.26 1.75 -0.07 -0.43 0.53 1 2 3 4 5 -1.83 1.83 HS.537804 -0.19 1.67 -0.16 -0.53 0.60 1 2 3 4 5 -1.83 1.83 TAS1R3 0.60 0.71 -1.12 0.40 -1.34 1 2 3 4 5 -1.83 1.83 HS.552428 2.31 3.18 1.35 1.51 0.05 1 2 3 4 5 -1.83 1.83 C90RF11 0.33 1.94 0.11 3.21 -0.41 1 2 3 4 5 -1.83 1.83 IFNE1 1.08 1.68 -0.15 -0.41 -0.45 1 2 3 4 5 -1.83 1.83 HCG22 0.59 1.60 -0.24 0.26 -0.52 1 2 3 4 5 -1.83 1.83 LRCH1 0.21 1.58 -0.25 -0.07 -0.15 1 2 3 4 5 -1.83 1.83 HS.512989 -0.58 1.45 -0.39 -0.53 -0.36 1 2 3 4 5 -1.83 1.83 HS.580616 1.76 1.37 -0.46 -0.17 1.19 1 2 3 4 5 -1.83 1.83 HS.561940 -0.03 1.64 -0.20 0.09 -0.11 1 2 3 4 5 -1.84 1.84 IYD 1.31 1.33 -0.50 -0.92 0.24 1 2 3 4 5 -1.84 1.84 NME2P1 0.36 2.24 0.40 0.68 -0.35 1 2 3 4 5 -1.84 1.84 GPR103 -0.28 1.64 -0.20 0.26 1.51 1 2 3 4 5 -1.84 1.84 HS.543634 0.18 2.22 0.39 -0.08 0.39 1 2 3 4 5 -1.84 1.84 RRH -1.11 2.61 0.77 -0.60 0.70 1 2 3 4 5 -1.84 1.84 HS.562661 0.41 2.47 0.63 1.55 2.44 1 2 3 4 5 -1.84 1.84 LOC653244 2.11 1.98 0.14 -0.17 -1.02 1 2 3 4 5 -1.84 1.84 PLA264D 0.13 1.46 -0.38 0.72 -0.57 1 2 3 4 5 -1.84 1.84 LOC651017 1.04 1.89 0.05 -0.11 1.20 1 2 3 4 5 -1.84 1.84 HS.554217 1.07 1.83 -0.01 -0.65 -0.57 1 2 3 4 5 -1.84 1.84 KIAA0527 1.61 1.95 0.11 2.28 1.82 1 2 3 4 5 -1.84 1.84 HS.577710 -0.58 1.64 -0.20 0.92 -0.33 1 2 3 4 5 -1.84 1.84 TIGD4 1.45 0.06 -1.78 -2.12 -1.04 1 2 3 4 5 -1.84 1.84 LOC338797 1.31 1.76 -0.08 -0.27 3.14 1 2 3 4 5 -1.84 1.84 FAM151A -0.89 0.63 -1.21 0.69 3.20 1 2 3 4 5 -1.84 1.84 HS.579084 0.39 0.83 -1.01 1.32 1.26 1 2 3 4 5 -1.84 1.84 HS.538477 1.59 2.41 0.56 -0.21 0.23 1 2 3 4 5 -1.84 1.84 HS.528546 0.55 1.68 -0.16 0.60 -0.17 1 2 3 4 5 -1.84 1.84 LOC649921 0.29 2.64 0.80 -0.75 -0.82 1 2 3 4 5 -1.84 1.84 PPEF2 0.94 1.12 -0.72 -0.47 1.27 1 2 3 4 5 -1.84 1.84 HS.569718 -0.01 2.38 0.54 1.57 0.39 1 2 3 4 5 -1.84 1.84 Table 3 151 SATL1 0.47 1.35 -0.50 1.50 -0.16 1 2 3 4 5 -1.84 1.84 HS.575773 0.03 1.87 0.03 -0.18 -0.45 1 2 3 4 5 -1.85 1.85 HS.540833 0.77 1.53 -0.31 -0.37 -0.34 1 2 3 4 5 -1.85 1.85 HS.333330 3.18 2.85 1.01 1.61 0.48 1 2 3 4 5 -1.85 1.85 LOC648230 2.01 1.65 -0.20 0.07 0.20 1 2 3 4 5 -1.85 1.85 HS.291993 0.99 2.83 0.98 0.12 -0.47 1 2 3 4 5 -1.85 1.85 HS.550452 -0.28 1.54 -0.31 0.36 0.49 1 2 3 4 5 -1.85 1.85 HS.116507 0.04 0.58 -1.27 -1.39 -1.79 1 2 3 4 5 -1.85 1.85 HS.545747 0.23 1.62 -0.23 -0.69 -0.26 1 2 3 4 5 -1.85 1.85 C60RF184 4.54 2.09 0.24 1.91 0.28 1 2 3 4 5 -1.85 1.85 C120RF25 -0.43 2.33 0.48 -0.18 -0.53 1 2 3 4 5 -1.85 1.85 HS.545728 -0.47 1.54 -0.31 -0.51 -0.40 1 2 3 4 5 -1.85 1.85 GIPC2 0.82 1.41 -0.44 1.59 -0.78 1 2 3 4 5 -1.85 1.85 HS.539286 0.45 2.40 0.55 -0.21 1.28 1 2 3 4 5 -1.85 1.85 HS.576993 0.64 1.74 -0.11 2.18 -0.24 1 2 3 4 5 -1.86 1.86 HS.521641 -0.08 0.94 -0.91 -0.63 -0.42 1 2 3 4 5 -1.86 1.86 HS.551896 -0.06 1.55 -0.31 -0.02 -0.17 1 2 3 4 5 -1.86 1.86 KCNG3 1.00 2.23 0.37 3.12 1.13 1 2 3 4 5 -1.86 1.86 C80RF71 -0.30 0.80 -1.06 -0.42 -0.03 1 2 3 4 5 -1.86 1.86 NFATC2 2.54 2.98 1.12 0.81 -1.57 1 2 3 4 5 -1.86 1.86 AGI3 2.30 0.67 -1.19 -0.20 0.70 1 2 3 4 5 -1.86 1.86 PSG2 0.61: 1.64 -0.22 -1.02 -0.65 1 2 3 4 5 -1.86 1.86 HS.543224 -0.33 1.70 -0.17 -0.21 -0.38 1 2 3 4 5 -1.86 1.86 HS.116147 0.07 1.51 -0.35 1.27 1.38 1 2 3 4 5 -1.86 1.86 VCX3A 1.21 1.91 0.05 0.42 0.07 1 2 3 4 5 -1.86 1.86 C60RF154 4.94 0.94 -0.92 0.24 0.18 1 2 3 4 5 -1.86 1.86 SPP1 -0.17 1.81 -0.05 0.57 -0.18 1 2 3 4 5 -1.86 1.86 KRTAP10-3 -0.71 0.93 -0.93 0.97 0.87 1 2 3 4 5 -1.86 1.86 HS.540262 -1.07. 0.75 -1.11 2.44 -1.51 1 2 3 4 5 -1.86 1.86 LCE3B -0.49 0.73 -1.13 -1.10 0.60 1 2 3 4 5 -1.86 1.86 LOC255275 -0.55 1.20 -0.66 -0.56 1.14 1 2 3 4 5 -1.86 1.86 HS.574658 -0.18 1.73 -0.14 -0.22 0.08 1 2 3 4 5 -1.87 1.87 DPPA2 -0.08 1.58 -0.29 0.51 0.07 1 2 3 4 5 -1.87 1.87 D TB1 -0.31 1.17 -0.70 0.05 0.38 1 2 3 4 5 -1.87 1.87 LOC648955 -0.47 1.53 -0.34 0.09 0.71 1 2 3 4 5 -1.87 1.87 SULT2A1 -0.52 1.98 0.12 0.47 0.81 1 2 3 4 5 -1.87 1.87 HS.61596 -0.12 1.23 -0.64 0.42 1.48 1 2 3 4 5 -1.87 1.87 HS.540808 1.54 2.49 0.62 -0.39 0.22 1 2 3 4 5 -1.87 1.87 HS.149200 1.87 1.36 -0.51 -0.91 -0.74 1 2 3 4 5 -1.87 1.87 HS.544941 -0.15 1.70 -0.18 -0.17 0.12 1 2 3 4 5 -1.87 1.87 0R1E1 -0.66 1.54 -0.33 -0.89 0.85 1 2 3 4 5 -1.87 1.87 LOC645652 -0.13 1.60 -0.28 0.06 -0.46 1 2 3 4 5 -1.87 1.87 HS.580198 -0.61 1.60 -0.27 0.81 0.57 1 2 3 4 5 -1.87 1.87 ZNF829 -0.29 1.75 -0.13 -0.03 -0.12 1 2 3 4 5 -1.87 1.87 HS.508311 -0.36 1.83 -0.05 0.01 1.39 1 2 3 4 5 -1.87 1.87 LOC650363 -0.10 1.52 -0.35 -0.21 -0.25 1 2 3 4 5 -1.87 1.87 HS.576743 0.47 1.72 -0.16 0.29 -0.49 1 2 3 4 5 -1.87 1.87 LOC642101 -0.12 2.57 0.70 1.08 0.15 1 2 3 4 5 -1.88 1.88 FOXN4 -0.70 2.26 0.38 0.51 -0.03 1 2 3 4 5 -1.88 1.88 Table 3 152 HS.434230 -0.03 1.51 -0.37 -0.23 -0.07 1 2 3 4 5 -1.88 1.88 HS.445139 -0.15 1.40 -0.47 0.69 1.00 1 2 3 4 5 -1.88 1.88 HS.127938 -0.39 1.58 -0.29 1.19 0.12 1 2 3 4 5 -1.88 1.88 LOC132706 0.03 1.63 -0.25 0.47 0.01 1 2 3 4 5 -1.88 1.88 RND3 -0.88 0.25 -1.62 0.74 0.20 1 2 3 4 5 -1.88 1.88 LOC648682 1.14 1.61 -0.26 -0.22 -0.18 1 2 3 4 5 -1.88 1.88 HS.128325 0.59 3.93 2.05 -0.58 1.35 1 2 3 4 5 -1.88 1.88 HS.147886 -0.24 1.46 -0.42 -0.08 -0.02 1 2 3 4 5 -1.88 1.88 HS.575003 0.03 1.43 -0.45 1.32 0.31 1 2 3 4 5 -1.88 1.88 LOC654164 0.30 1.85 -0.03 0.77 0.23 1 2 3 4 5 -1.88 1.88 LOC646970 5.02 1.58 -0.30 -0.08 -0.41 1 2 3 4 5 -1.88 1.88 HS.550967 0.20 1.72 -0.16 -0.91 -0.61 1 2 3 4 5 -1.88 1.88 HS.130612 1.11 -0.25 -2.13 3.91 -0.39 1 2 3 4 5 -1.88 1.88 HS.386102 1.18 0.99 -0.90 1.55 -0.20 1 2 3 4 5 -1.89 1.89 HS.571370 1.57 1.89 0.00 0.23 1.24 1 2 3 4 5 -1.89 1.89 HS.563304 0.78 1.84 -0.04 -0.17 -0.03 1 2 3 4 5 -1.89 1.89 HS.562084 -0.97 1.12 -0.77 -0.28 -0.04 1 2 3 4 5 -1.89 1.89 RGS8 -0.76 1.33 -0.56 -1.16 -0.80 1 2 3 4 5 -1.89 1.89 HS.550254 -0.37 1.75 -0.14 -0.34 0.27 1 2 3 4 5 -1.89 1.89 HS.439870 0.41 1.86 -0.03 -0.43 0.52 1 2 3 4 5 -1.89 1.89 LOC643869 1.56 1.73 -0.16 0.59 -0.69 1 2 3 4 5 -1.89 1.89 TTN -0.30 1.86 -0.04 -0.08 0.87 1 2 3 4 5 -1.89 1.89 LOC728285 1.13' 3.20 1.31 2.17 0.39 1 2 3 4 5 -1.89 1.89 HS.545546 0.65 1.50 -0.39 0.42 0.00 1 2 3 4 5 -1.89 1.89 FGFR1 1.26; 0.95 -0.94 -0.72 -1.12 1 2 3 4 5 -1.89 1.89 HS.128649 0.46 2.19 0.30 1.79 -0.26 1 2 3 4 5 -1.89 1.89 E L5 -0.06 1.77 -0.12 -0.25 -0.08 1 2 3 4 5 -1.89 1.89 HS.538800 1.00 1.14 -0.75 2.53 1.84 1 2 3 4 S -1.89 1.89 HS.210441 1.47 2.42 0.53 0.55 0.08 1 2 3 4 5 -1.89 1.89 LOC647042 0.07 1.89 0.00 0.05 0.08 1 2 3 4 5 -1.89 1.89 HS.541249 2.96 2.39 0.50 0.68 -0.20 1 2 3 4 5 -1.89 1.89 LOC646649 0.48 1.61 -0.28 2.25 0.28 1 2 3 4 5 -1.89 1.89 HS.551042 0.46 1.72 -0.17 -0.06 -0.07 1 2 3 4 5 -1.89 1.89 CBWD2 -0.37 1.40 -0.49 -0.69 -0.52 1 2 3 4 5 -1.90 1.90 HS.259583 0.45 1.50 -0.40 0.17 -0.11 1 2 3 4 5 -1.90 1.90 LOC643621 -0.20 1.81 -0.09 0.03 -0.37 1 2 3 4 5 -1.90 1.90 HS.149762 0.07 1.79 -0.11 -0.11 0.32 1 2 3 4 5 -1.90 1.90 HS.383001 0.67 2.20 0.31 -0.01 -0.27 1 2 3 4 5 -1.90 1.90 HS.575141 1.03 2.64 0.74 -0.51 4.39 1 2 3 4 5 -1.90 1.90 LOC652379 0.04 1.46 -0.44 -0.11 -0.12 1 2 3 4 5 -1.90 1.90 LOC400095 0.35 3.28 1.38 -0.91 1.01 1 2 3 4 5 -1.90 1.90 LOC654085 -0.07 1.48 -0.42 -0.49 -0.65 1 2 3 4 5 -1.90 1.90 LOC390530 0.90 2.88 0.98 -0.35 2.61 1 2 3 4 5 -1.90 1.90 LOC642611 -0.44 1.16 -0.74 0.63 -0.56 1 2 3 4 5 -1.90 1.90 ZNF705A -0.70 1.23 -0.67 0.52 0.52 1 2 3 4 5 -1.90 1.90 LOC728080 0.02 1.76 -0.15 -0.17 0.57 1 2 3 4 5 -1.90 1.90 LOC643677 0.20 1.26 -0.64 0.04 0.93 1 2 3 4 5 -1.90 1.90 HSD11B1 0.89 1.71 -0.19 -0.14 0.16 1 2 3 4 5 -1.90 1.90 HS.368591 -0.02 1.68 -0.22 0.05 0.51 1 2 3 4 5 -1.90 1.90 Table 3 1 SCN11A 0.20 2.42 0.52 5.69 -1.16 1 2 3 4 5 -1.90 1.90 HS.564922 -0.10 1.60 -0.30 0.33 -0.11 1 2 3 4 5 -1.90 1.90 GAL3ST3 1.15 1.99 0.08 -0.08 0.99 1 2 3 4 5 -1.90 1.90 HS.563971 1.41 1.64 -0.26 -0.73 4.51 1 2 3 4 5 -1.91 1.91 OR51L1 -0.41 0.99 -0.92 0.24 0.27 1 2 3 4 5 -1.91 1.91 HS.509152 1.93 0.88 -1.03 -0.83 -1.37 1 2 3 4 5 -1.91 1.91 HS.582429 3.51 1.61 -0.30 0.60 -1.07 1 2 3 4 5 -1.91 1.91 FOXQ1 0.12 1.32 -0.59 -0.35 0.20 1 2 3 4 5 -1.91 1.91 HS.554718 -0.24 2.23 0.32 0.31 -0.06 1 2 3 4 5 -1.91 1.91 HS.170439 -1.18 1.49 -0.42 -0.29 2.83 1 2 3 4 5 -1.91 1.91 HS.542879 0.98 1.97 0.06 -0.43 -0.63 1 2 3 4 5 -1.91 1.91 LOC642290 -0.06 1.96 0.05 0.06 0.02 1 2 3 4 5 -1.91 1.91 LOC643186 -0.34 2.28 0.37 0.64 0.48 1 2 3 4 5 -1.91 1.91 LOC400942 1.71 1.61 -0.30 -0.30 0.88 1 2 3 4 5 -1.91 1.91 NPBWR1 -0.66 2.59 0.68 1.38 -0.05 1 2 3 4 5 -1.91 1.91 OR5H14 2.15 0.70 -1.22 1.19 -2.18 1 2 3 4 5 -1.91 1.91 HS.544218 -0.55 0.94 -0.97 1.02 0.43 1 2 3 4 5 -1.91 1.91 HS.544846 -0.59 1.51 -0.41 -0.03 0.05 1 2 3 4 5 -1.91 1.91 LOC645218 -0.19 2.07 0.15 0.19 -0.24 1 2 3 4 5 -1.92 1.92 MKX -0.87 0.45 -1.47 -2.24 -1.62 1 2 3 4 5 -1.92 1.92 HS.584341 0.06 1.94 0.02 0.10 -0.05 1 2 3 4 5 -1.92 1.92 HS.577998 0.36 0.89 -1.03 -0.93 -0.08 1 2 3 4 5 -1.92 1.92 SNCB -0.59 2.39 0.47 -0.21 -0.13 1 2 3 4 5 -1.93 1.93 HS.581405 -0.21 1.50 -0.42 -0.50 -0.44 1 2 3 4 5 -1.93 1.93 HS.538805 0.94 1.64 -0.29 4.77 -0.48 1 2 3 4 5 -1.93 1.93 HS.573674 -0.08 1.61 -0.32 1.75 0.96 1 2 3 4 5 -1.93 1.93 HS.542979 0.67 2.24 0.31 -0.28 0.26 1 2 3 4 5 -1.93 1.93 HS.544409 -0.09 3.20 1.27 0.03 3.04 1 2 3 4 -1.93 1.93 HS.130213 0.64 1.32 -0.61 0.43 -0.62 1 2 3 4 5 -1.93 1.93 SNTG1 0.27: -0.04 -1.97 1.94 0.79 1 2 3 4 5 -1.93 1.93 HS.122956 1.23 1.55 -0.38 -0.67 -0.93 1 2 3 4 5 -1.93 1.93 HS.564740 1.01 1.64 -0.29 0.95 -0.03 1 2 3 4 5 -1.93 1.93 ZBTB12 -0.23 0.45 -1.49 0.48 -1.32 1 2 3 4 5 -1.93 1.93 HS.542903 -0.78 2.65 0.72 1.78 -0.65 1 2 3 4 5 -1.93 1.93 NAT8 0.73 1.70 -0.23 -0.11 -0.39 1 2 3 4 5 -1.93 1.93 HS.545555 6.88 2.56 0.63 3.19 -0.72 1 2 3 4 5 -1.93 1.93 LOC646638 -0.01 2.05 0.11 -0.25 0.29 1 2 3 4 5 -1.94 1.94 HS.434904 -0.45 2.65 0.71 -1.00 -0.24 1 2 3 4 5 -1.94 1.94 IL1RAPL1 0.21 1.51 -0.43 -0.45 0.33 1 2 3 4 5 -1.94 1.94 LOC442446 1.75 1.01 -0.93 1.03 -0.61 1 2 3 4 5 -1.94 1.94 HS.201714 -0.30 1.56 -0.38 -0.41 0.60 1 2 3 4 5 -1.94 1.94 C40RF21 -0.35 1.42 -0.52 4.72 3.42 1 2 3 4 5 -1.94 1.94 TLX2 -0.34 1.16 -0.78 -0.64 2.33 1 2 3 4 5 -1.94 1.94 LOC731042 0.24 1.42 -0.52 -0.10 1.80 1 2 3 4 5 -1.94 1.94 CGB2 2.93 0.65 -1.29 -1.26 0.49 1 2 3 4 5 -1.94 1.94 HS.559722 1.15 2.28 0.34 1.97 0.31 1 2 3 4 5 -1.94 1.94 HS.557985 -0.29 3.06 1.12 -0.31 0.78 1 2 3 4 5 -1.94 1.94 SMPX 3.93 1.94 0.00 -0.04 -0.05 1 2 3 4 5 -1.94 1.94 HS.541486 1.18 1.62 -0.32 -0.49 1.54 1 2 3 4 5 -1.94 1.94 Table 3 154 GDF3 0.92 1.61 -0.33 0.12 -0.49 1 2 3 4 5 -1.94 1.94 W D 87 -0.21 1.43 -0.51 0.23 -0.28 1 2 3 4 5 -1.95 1.95 COMP 0.64 0.09 -1.85 -0.16 -0.92 1 2 3 4 5 -1.95 1.95 HRH3 3.04 1.71 -0.24 2.54 4.04 1 2 3 4 5 -1.95 1.95 HS.552131 -0.04 1.77 -0.18 0.46 0.53 1 2 3 4 5 -1.95 1.95 LOC649942 0.13 1.78 -0.17 0.80 0.22 1 2 3 4 5 -1.95 1.95 DKFZP434B061 -0.74 2.45 0.51 -0.29 -0.51 1 2 3 4 5 -1.95 1.95 KRTAP6-2 0.21 1.47 -0.48 0.49 0.72 1 2 3 4 5 -1.95 1.95 LOC652575 -0.24 1.28 -0.67 0.02 0.43 1 2 3 4 5 -1.95 1.95 WNK2 -0.35 1.34 -0.61 -0.81 0.19 1 2 3 4 5 -1.95 1.95 LOC647306 0.41 2.20 0.24 0.39 0.15 1 2 3 4 5 -1.95 1.95 ADCY5 0.56 1.87 -0.09 -1.26 3.45 1 2 3 4 5 -1.95 1.95 HS.539795 1.05 3.09 1.14 0.09 1.53 1 2 3 4 5 -1.95 1.95 LOC642948 4.15 3.72 1.76 -1.35 3.01 1 2 3 4 5 -1.95 1.95 TTC9B -0.66 2.33 0.38 0.27 -0.27 1 2 3 4 5 -1.95 1.95 HS.363473 0.58 1.21 -0.74 0.20 0.01 1 2 3 4 5 -1.95 1.95 HS.536630 1.50 0.56 -1.40 -0.36 -0.81 1 2 3 4 5 -1.95 1.95 LOC730411 1.72 1.61 -0.35 0.39 0.24 1 2 3 4 5 -1.95 1.95 LOC652233 0.08 1.93 -0.02 0.03 0.13 1 2 3 4 5 -1.95 1.95 NR4A3 -0.85 1.92 -0.03 -0.69 -0.13 1 2 3 4 5 -1.95 1.95 CHRM2 2.16 2.55 0.59 1.61 0.39 1 2 3 4 -1.96 1.96 TEKT4 -2.28 0.58 -1.38 -1.46 1.40 1 2 3 4 5 -1.96 1.96 LOC642173 0.51 1.98 0.02 -0.66 -0.44 1 2 3 4 5 -1.96 1.96 SSX5 0.74 1.51 -0.45 -0.57 2.89 1 2 3 4 5 -1.96 1.96 HS.446286 0.20 1.55 -0.41 -0.65 0.49 1 2 3 4 5 -1.96 1.96 HS.551331 0.79 1.78 -0.18 0.51 -0.20 1 2 3 4 5 -1.96 1.96 HS.372832 0.47 1.71 -0.25 0.47 0.27 1 2 3 4 5 -1.96 1.96 HS.233221 0.52 1.89 -0.07 -0.13 2.01 1 2 3 4 5 -1.96 1.96 ZNF221 -0.30 2.25 0.29 -0.50 4.22 1 2 3 4 5 -1.96 1.96 LOC401164 0.15 2.08 0.12 -0.46 1.96 1 2 3 4 5 -1.96 1.96 XAGE2 -1.27 1.95 -0.01 2.40 0.85 1 2 3 4 5 -1.96 1.96 HS.201721 0.13 0.96 -1.00 0.30 -0.14 1 2 3 4 5 -1.96 1.96 LOC400752 0.36 1.49 -0.47 0.19 0.52 1 2 3 4 5 -1.96 1.96 SLPI 0.25 1.54 -0.43 1.00 -0.44 1 2 3 4 5 -1.96 1.96 HS.282540 -0.17 0.72 -1.24 0.01 -0.45 1 2 3 4 5 -1.96 1.96 HS.580799 -0.07 1.36 -0.61 0.32 -0.12 1 2 3 4 5 -1.97 1.97 HOXA11 0.24 1.32 -0.64 -0.42 1.56 1 2 3 4 5 -1.97 1.97 TMPRSS11A -0.38 1.63 -0.34 -0.02 0.11 1 2 3 4 5 -1.97 1.97 HS.371717 -0.01 1.07 -0.90 -0.02 -0.74 1 2 3 4 5 -1.97 1.97 LOC646486 -1.56 1.09 -0.88 2.01 0.37 1 2 3 4 5 -1.97 1.97 LOC730242 -0.17 1.65 -0.32 -0.06 2.27 1 2 3 4 5 -1.97 1.97 LOC650212 -0.80 0.89 -1.08 1.48 -0.78 1 2 3 4 5 -1.97 1.97 HS.169979 0.31 1.84 -0.14 0.76 -0.30 1 2 3 4 5 -1.97 1.97 HS.566185 1.45 1.61 -0.36 0.65 0.53 1 2 3 4 5 -1.97 1.97 HS.564927 0.05 1.48 -0.49 -0.24 -0.20 1 2 3 4 5 -1.97 1.97 LST-3TM12 0.50 1.70 -0.28 -0.45 -0.55 1 2 3 4 5 -1.97 1.97 LOC196541 -0.60 1.57 -0.41 -0.85 0.06 1 2 3 4 5 -1.97 1.97 LOC643431 1.24 0.88 -1.10 0.18 -0.62 1 2 3 4 5 -1.98 1.98 LOC651609 0.10 1.43 -0.55 0.70 0.31 1 2 3 4 5 -1.98 1.98 Table 3 155 LOC648846 0.10 1.85 -0.12 -0.21 1.71 1 2 3 4 5 -1.98 1.98 HS.130866 -0.29 2.53 0.56 0.76 0.98 1 2 3 4 5 -1.98 1.98 HS.580972 2.42 2.53 0.56 -0.64 0.77 1 2 3 4 5 -1.98 1.98 BAPX1 -0.08 0.19 -1.78 1.46 -0.57 1 2 3 4 5 -1.98 1.98 HS.544507 -0.03 1.79 -0.18 -0.09 0.84 1 2 3 4 5 -1.98 1.98 HS.570324 -0.12 1.61 -0.37 -0.08 -0.27 1 2 3 4 5 -1.98 1.98 HS.446170 1.01 1.55 -0.42 0.91 -0.50 1 2 3 4 5 -1.98 1.98 KRT12 -0.96 1.25 -0.72 -0.56 1.07 1 2 3 4 5 -1.98 1.98 GALNTL2 1.74 2.22 0.24 0.09 0.95 1 2 3 4 5 -1.98 1.98 HS.553363 3.73 1.15 -0.83 2.30 0.06 1 2 3 4 5 -1.98 1.98 HS.575903 0.52 2.62 0.64 0.29 0.93 1 2 3 4 5 -1.98 1.98 HS.545744 -0.62 1.21 -0.77 -0.27 0.93 1 2 3 4 5 -1.98 1.98 YSK4 -1.12 1.81 -0.17 2.75 0.50 1 2 3 4 5 -1.98 1.98 LOC649967 -0.62 1.37 -0.61 1.07 -0.69 1 2 3 4 5 -1.98 1.98 HS.46941 -0.26 2.67 0.68 1.02 -0.14 1 2 3 4 5 -1.98 1.98 HS.538770 0.85 1.07 -0.92 -1.13 0.67 1 2 3 4 5 -1.99 1.99 HS.458445 -0.23 1.63 -0.36 -0.10 0.26 1 2 3 4 5 -1.99 1.99 LOC652647 -0.21 1.04 -0.95 3.51 0.08 1 2 3 4 5 -1.99 1.99 HS.542107 -0.48 1.98 -0.01 -0.09 0.06 1 2 3 4 5 -1.99 1.99 HS.544020 2.10 1.67 -0.32 0.80 0.90 1 2 3 4 5 -1.99 1.99 HS.573286 -0.68 2.35 0.36 2.07 0.90 1 2 3 4 5 -1.99 1.99 HS.539595 0.30: 1.99 0.00 0.04 0.39 1 2 3 4 5 -1.99 1.99 LOC644152 2.18 1.52 -0.47 0.53 0.31 1 2 3 4 5 -1.99 1.99 HS.545017 1.18 2.52 0.53 -0.06 0.02 1 2 3 4 5 -1.99 1.99 HS. 147826 0.85 1.40 -0.60 0.47 0.38 1 2 3 4 5 -1.99 1.99 HS.571574 -0.06 1.02 -0.98 0.01 0.07 1 2 3 4 5 -1.99 1.99 TDGF1 7.17 1.64 -0.35 -0.84 -0.18 1 2 3 4 5 -1.99 1.99 HS.156135 0.25 1.40 -0.60 0.52 -0.29 1 2 3 4 5 -1.99 1.99 PCDHB18 0.48 2.05 0.06 0.32 -0.32 1 2 3 4 5 -1.99 1.99 LOC650810 -0.31 1.62 -0.38 -0.32 -0.29 1 2 3 4 5 -2.00 2.00 KALI -0.51 0.52 -1.48 -0.21 0.59 1 2 3 4 5 -2.00 2.00 HS.129402 0.91 0.89 -1.11 -0.72 2.41 1 2 3 4 5 -2.00 2.00 LOC644325 0.10 1.32 -0.69 -0.42 -0.26 1 2 3 4 5 -2.00 2.00 LOC285141 1.24 1.15 -0.86 0.84 1.04 1 . 2 3 4 5 -2.00 2.00 HS.131297 1.07 3.86 1.86 -0.45 0.79 1 2 3 4 5 -2.00 2.00 HS.538166 -0.14 1.80 -0.21 -0.09 -0.21 1 2 3 4 5 -2.01 2.01 HS.104943 1.31 3.17 1.16 -1.09 -0.07 1 2 3 4 5 -2.01 2.01 VTN 0.99 0.94 -1.07 -1.93 2.93 1 2 3 4 5 -2.01 2.01 HS.571336 0.76 1.68 -0.33 -0.55 0.01 1 2 3 4 5 -2.01 2.01 HS.557747 1.68 1.73 -0.29 2.95 -0.26 1 2 3 4 5 -2.01 2.01 LOC653514 0.55 1.72 -0.29 -0.65 0.54 1 2 3 4 5 -2.01 2.01 LOC644207 -0.13 1.46 -0.56 2.48 -0.15 1 2 3 4 5 -2.02 2.02 TTC21B 1.03 0.86 -1.16 1.50 1.49 1 2 3 4 5 -2.02 2.02 HS.542672 0.86 2.17 0.15 2.02 0.79 1 2 3 4 5 -2.02 2.02 ELF5 2.59 3.22 1.20 0.41 0.27 1 2 3 4 5 -2.02 2.02 STAB2 0.87 1.06 -0.96 0.54 0.98 1 2 3 4 5 -2.02 2.02 0R2B11 1.38 3.04 1.02 0.26 1.34 1 2 3 4 5 -2.02 2.02 LOC145837 -0.47 1.35 -0.67 -0.31 -0.62 1 2 3 4 5 -2.02 2.02 HS.364872 0.99 2.21 0.18 0.11 0.21 1 2 3 4 5 -2.02 2.02 Table 3 156 CHRNG 0.76 1.31 -0.71 1.32 0.77 1 2 3 4 5 -2.02 2.02 LOC653238 1.35 3.49 1.47 0.76 -0.02 1 2 3 4 5 -2.02 2.02 HS.577287 2.73 1.82 -0.20 0.13 -0.41 1 2 3 4 5 -2.02 2.02 LOC651790 -0.38 1.27 -0.75 0.77 -0.27 1 2 3 4 5 -2.02 2.02 LOC388946 0.61 2.10 0.08 0.32 0.49 1 2 3 4 5 -2.02 2.02 LOC652898 1.12 0.20 -1.83 0.90 -0.43 1 2 3 4 5 -2.02 2.02 USH1C 2.17 2.79 0.77 0.49 0.33 1 2 3 4 5 -2.03 2.03 LOC648763 1.09 2.60 0.57 -0.38 -0.26 1 2 3 4 5 -2.03 2.03 DGKI -0.53 2.01 -0.02 -0.19 0.54 1 2 3 4 5 -2.03 2.03 HS.582939 -0.07 2.02 -0.01 -0.09 -0.34 1 2 3 4 5 -2.03 2.03 FU45964 0.11 1.89 -0.14 0.75 0.11 1 2 3 4 5 -2.03 2.03 LOC642761 0.58 1.66 -0.37 -0.27 0.09 1 2 3 4 5 -2.03 2.03 DMRT1 -1.09 1.70 -0.33 0.78 -0.18 1 2 3 4 5 -2.03 2.03 HS.54773 -0.33 2.06 0.03 -0.32 -0.07 1 2 3 4 5 -2.03 2.03 HS.544903 -0.13 2.01 -0.02 0.84 -0.38 1 2 3 4 5 -2.03 2.03 LOC650721 1.85 3.65 1.61 -0.34 0.91 1 2 3 4 5 -2.03 2.03 LOC642312 0.30 1.87 -0.16 -0.12 -0.21 1 2 3 4 5 -2.03 2.03 HS.121185 0.51 1.71 -0.32 1.91 -0.44 1 2 3 4 5 -2.03 2.03 HS.105551 0.12 0.66 -1.38 -0.03 -1.16 1 2 3 4 5 -2.03 2.03 LOC126147 -0.07 1.91 -0.13 0.00 -0.04 1 2 3 4 5 -2.04 2.04 HS.568324 0.62 1.94 -0.10 -0.56 -0.58 1 2 3 4 5 -2.04 2.04 COL4A3 0.12 2.34 0.30 -0.15 0.08 1 2 3 4 5 -2.04 2.04 HS.546175 0.44 2.10 0.06 0.37 -0.45 1 2 3 4 5 -2.04 2.04 HS.147320 -0.11 1.78 -0.26 -0.35 1.49 1 2 3 4 5 -2.04 2.04 HS.121375 -0.41 1.37 -0.67 -0.40 -0.56 1 2 3 4 5 -2.04 2.04 HS.38448 1.45 1.35 -0.70 2.76 0.24 1 2 3 4 5 -2.04 2.04 HS.582543 -0.13 1.54 -0.50 0.46 -0.13 1 2 3 4 5 -2.04 2.04 HS.125589 0.18 3.22 1.18 -1.01 0.31 1 2 3 4 5 -2.04 2.04 HS.543923 1.51 2.09 0.04 -0.34 0.93 1 2 3 4 5 -2.05 2.05 HS.538645 0.00 1.86 -0.18 0.99 1.07 1 2 3 4 5 -2.05 2.05 HS.542166 0.08 1.68 -0.36 0.69 0.10 1 2 3 4 5 -2.05 2.05 HS.371300 0.08 2.81 0.76 -0.29 0.45 1 2 3 4 5 -2.05 2.05 ANGPTL1 -0.53 0.65 -1.40 1.57 -0.62 1 2 3 4 5 -2.05 2.05 IL28A 1.47 2.43 0.38 1.88 0.55 1 2 3 4 5 -2.05 2.05 HS.545371 0.73 1.16 -0.89 5.67 1.12 1 2 3 4 5 -2.05 2.05 HS.543981 0.25 2.05 0.00 0.66 0.37 1 2 3 4 5 -2.05 2.05 LOC401957 -0.07 1.58 -0.47 0.54 0.06 1 2 3 4 5 -2.05 2.05 HS.539280 -0.87 1.56 -0.49 0.71 1.53 1 2 3 4 5 -2.05 2.05 HS.540787 -0.54 1.56 -0.49 1.39 0.40 1 2 3 4 5 -2.05 2.05 HS.575810 -0.09 2.11 0.06 -0.25 -0.33 1 2 3 4 5 -2.05 2.05 HS.578562 -0.10 2.00 -0.05 0.44 -0.26 1 2 3 4 5 -2.05 2.05 HS.553273 0.16 1.64 -0.42 0.16 1.34 1 2 3 4 5 -2.05 2.05 HS.264606 -0.70 1.81 -0.24 0.00 -0.10 1 2 3 4 5 -2.05 2.05 HS.27094 0.70 2.85 0.80 -0.44 -0.15 1 2 3 4 5 -2.05 2.05 HS.583753 -0.08 1.74 -0.32 2.99 -0.46 1 2 3 4 5 -2.06 2.06 TTTY4C -0.26 1.24 -0.82 -0.78 1.06 1 2 3 4 5 -2.06 2.06 HS.339290 -0.40 1.30 -0.76 0.57 -0.47 1 2 3 4 5 -2.06 2.06 MYL4 0.04 2.20 0.15 -0.43 0.43 1 2 3 4 5 -2.06 2.06 HS.537637 -0.52 1.57 -0.48 -0.18 -0.04 1 2 3 4 5 -2.06 2.06 Table 3 157 HS.557513 0.04 1.58 -0.48 -0.17 0.41 1 2 3 4 5 -2.06 2.06 ZNF180 -0.30 2.14 0.08 -1.61 -1.48 1 2 3 4 5 -2.06 2.06 HS.575701 -1.25 0.95 -1.11 0.51 -0.81 1 2 3 4 5 -2.06 2.06 GGN 0.70 1.67 -0.39 1.81 -0.97 1 2 3 4 5 -2.06 2.06 AKR1B10 1.50 2.05 -0.01 0.28 0.55 1 2 3 4 5 -2.06 2.06 FM09P 0.50 1.43 -0.64 0.10 1.05 1 2 3 4 5 -2.06 2.06 LOC728219 -0.45 1.58 -0.48 -0.65 0.35 1 2 3 4 5 -2.06 2.06 HS.571032 1.21 3.27 1.21 -0.49 -0.17 1 2 3 4 5 -2.06 2.06 HS.565905 0.08 2.33 0.26 0.54 0.13 1 2 3 4 5 -2.06 2.06 CNTN1 -0.99 1.98 -0.09 -0.12 -1.26 1 2 3 4 5 -2.07 2.07 OR2T27 0.11 1.53 -0.54 -0.38 1.63 1 2 3 4 5 -2.07 2.07 HS.561071 -0.17 2.21 0.14 -0.11 0.05 1 2 3 4 5 -2.07 2.07 C10ORF71 0.51 0.18 -1.88 3.68 0.30 1 2 3 4 5 -2.07 2.07 KRTAP21-2 0.62 1.48 -0.59 3.22 1.06 1 2 3 4 5 -2.07 2.07 HS.571536 0.66 1.99 -0.08 0.87 -0.15 1 2 3 4 5 -2.07 2.07 WDR64 0.47 1.81 -0.27 -0.11 0.36 1 2 3 4 5 -2.07 2.07 HS.441628 0.28 1.51 -0.57 -0.32 -0.18 1 2 3 4 5 -2.07 2.07 LOC402117 0.72 1.57 -0.51 2.51 -0.60 1 2 3 4 5 -2.08 2.08 HS.65839 -0.73 1.62 -0.46 0.61 2.73 1 2 3 4 5 -2.08 2.08 HS.571822 0.22 0.69 -1.38 0.10 -0.92 1 2 3 4 5 -2.08 2.08 PTGER1 -0.28 1.34 -0.74 -0.19 -0.53 1 2 3 4 5 -2.08 2.08 HS.576632 0.43 1.84 -0.24 -0.32 1.50 1 2 3 4 5 -2.08 2.08 LOC653579 0.16 1.74 -0.34 -0.02 0.09 1 2 3 4 5 -2.08 2.08 LOC652670 1.07 2.55 0.47 1.39 0.94 1 2 3 4 5 -2.08 2.08 HS.518695 -0.61 1.71 -0.37 0.31 0.07 1 2 3 4 5 -2.08 2.08 HS.538344 -0.83 ! 1.69 -0.40 2.04 -0.01 1 2 3 4 5 -2.08 2.08 HS.147457 -0.80 1.47 -0.61 0.46 1.04 1 2 3 4 5 -2.08 2.08 HS.537591 0.45 1.70 -0.39 -0.67 0.53 1 2 3 4 5 -2.08 2.08 HS.391327 0.72 1.70 -0.38 0.78 0.46 1 2 3 4 5 -2.08 2.08 OR2T3 2.84 0.79 -1.29 -0.20 -0.67 1 2 3 4 5 -2.09 2.09 LOC646361 0.31 1.74 -0.35 0.02 1.60 1 2 3 4 5 -2.09 2.09 OR5T1 0.69 0.38 -1.71 2.44 -1.06 1 2 3 4 5 -2.09 2.09 PCDHGC4 -0.48 0.75 -1.33 0.08 0.93 1 2 3 4 5 -2.09 2.09 LOC647533 1.23 1.23 -0.85 2.58 0.53 1 2 3 4 5 -2.09 2.09 HS.541721 0.30 1.96 -0.13 0.29 0.55 1 2 3 4 5 -2.09 2.09 HS.127180 0.12 1.50 -0.59 0.04 -0.03 1 2 3 4 5 -2.09 2.09 HS.573241 2.12 : 2.23 0.14 0.46 0.74 1 2 3 4 5 -2.09 2.09 HS.561064 1.11 ; 2.83 0.74 1.63 -0.31 1 2 3 4 5 -2.09 2.09 HS.554016 0.35 : 1.66 -0.44 2.17 0.48 1 2 3 4 5 -2.10 2.10 LOC729218 0.71 1.30 -0.80 1.40 -0.64 1 2 3 4 5 -2.10 2.10 HS.564833 0.03 1.67 -0.43 -0.08 -0.22 1 2 3 4 5 -2.10 2.10 KLHL4 1.79 1.88 -0.22 1.04 -0.12 1 2 3 4 5 -2.10 2.10 HS.527684 -0.14 2.06 -0.04 0.46 -0.06 1 2 3 4 5 -2.10 2.10 HS.375537 -0.10 2.96 0.85 4.32 2.03 1 2 3 4 5 -2.10 2.10 ZP4 0.43 2.24 0.14 4.60 1.39 1 2 3 4 5 -2.10 2.10 HS.334275 -0.16 2.58 0.47 0.54 -0.01 1 2 3 4 5 -2.10 2.10 HS.573982 -0.21 2.30 0.20 -0.52 2.02 1 2 3 4 5 -2.10 2.10 HS.437410 0.20 2.52 0.41 0.25 0.60 1 2 3 4 5 -2.11 2.11 HS.582599 -1.09 1.29 -0.82 -0.84 -0.12 1 2 3 4 5 -2.11 2.11 Table 3 158 HS.542886 -1.01 0.79 -1.32 -0.51 3.26 1 2 3 4 5 -2.11 2.11 HS.541076 1.33 1.99 -0.11 0.44 -0.18 1 2 3 4 5 -2.11 2.11 TPPP2 4.12 2.52 0.41 -1.67 -0.53 1 2 3 4 5 -2.11 2.11 LOC643002 0.77 3.24 1.13 -0.96 -0.19 1 2 3 4 5 -2.11 2.11 HS.539131 0.51 1.91 -0.21 -0.39 -0.54 1 2 3 4 5 -2.12 2.12 UGT2A3 0.81 1.57 -0.55 0.34 1.55 1 2 3 4 5 -2.12 2.12 NPHS1 0.51 2.67 0.55 3.68 1.45 1 2 3 4 5 -2.12 2.12 HS.564398 0.13 1.52 -0.60 3.17 0.81 1 2 3 4 5 -2.12 2.12 OR52N4 0.19 2.38 0.26 -0.14 -0.26 1 2 3 4 5 -2.12 2.12 HS.187190 -0.64 1.63 -0.49 0.23 1.19 1 2 3 4 5 -2.12 2.12 HS.122133 -0.14 2.65 0.53 0.68 0.35 1 2 3 4 5 -2.12 2.12 LOC653165 2.63 1.71 -0.41 -0.41 0.05 1 2 3 4 5 -2.12 2.12 PCDHB11 0.51 2.02 -0.10 2.46 0.15 1 2 3 4 5 -2.12 2.12 HS.578894 0.82 1.36 -0.77 0.74 -0.81 1 2 3 4 5 -2.13 2.13 LOC652552 0.20 1.83 -0.29 -0.07 0.34 1 2 3 4 5 -2.13 2.13 FAM62C 1.36 0.79 -1.34 -0.06 -0.12 1 2 3 4 5 -2.13 2.13 FAM106A 0.41 2.20 0.06 0.97 -0.38 1 2 3 4 5 -2.13 2.13 LOC642889 0.45 1.51 -0.62 1.28 1.20 1 2 3 4 5 -2.13 2.13 LOC652846 0.41 3.92 1.78 -0.07 1.80 1 2 3 4 5 -2.13 2.13 HS.170508 1.38 1.84 -0.29 0.67 4.23 1 2 3 4 5 -2.13 2.13 HS.577771 1.00 1.85 -0.28 0.03 0.57 1 2 3 4 5 -2.13 2.13 LOC648154 0.40 1.48 -0.66 2.33 2.56 1 2 3 4 5 -2.13 2.13 ADA 18 0.70 1.54 -0.60 2.79 -0.01 1 2 3 4 5 -2.14 2.14 LOC651769 -0.43 1.74 -0.40 -0.22 0.02 1 2 3 4 5 -2.14 2.14 LOC648775 2.36 1.49 -0.65 -0.92 -0.50 1 2 3 4 5 -2.14 2.14 HS.539934 0.48 2.12 -0.02 -0.18 0.31 1 2 3 4 5 -2.14 2.14 LOC652235 0.70 1.98 -0.16 0.28 -0.53 1 2 3 4 5 -2.14 2.14 HS.577983 -0.50 2.16 0.02 -0.14 0.23 1 2 3 4 5 -2.14 2.14 HS.134739 0.98 3.80 1.66 -1.70 -0.81 1 2 3 4 5 -2.14 2.14 SLC18A2 -0.54 2.03 -0.11 -0.13 0.05 1 2 3 4 5 -2.14 2.14 HS.545331 0.22 2.38 0.24 0.76 1.13 1 2 3 4 5 -2.15 2.15 D0CK4 -1.43 1.41 -0.73 -0.88 1.76 1 2 3 4 5 -2.15 2.15 HS.414104 0.37 1.95 -0.20 0.05 0.08 1 2 3 4 5 -2.15 2.15 UGT1A7 0.49 1.42 -0.73 0.97 0.79 1 2 3 4 5 -2.15 2.15 LOC645104 1.09 2.51 0.36 0.88 -0.78 1 2 3 4 5 -2.15 2.15 HS.147593 0.69 1.69 -0.46 -0.38 -0.10 1 2 3 4 5 -2.15 2.15 HS.225853 1.14 2.05 -0.10 -0.08 0.39 1 2 3 4 5 -2.15 2.15 CRYGD 1.93 2.36 0.21 0.29 -0.05 1 2 3 4 5 -2.15 2.15 HS.580367 1.58 1.47 -0.68 -0.38 0.51 1 2 3 4 5 -2.15 2.15 LOC653441 -0.05 1.49 -0.66 2.35 -0.23 1 2 3 4 5 -2.15 2.15 HS.355823 -0.10 1.97 -0.19 -0.14 0.23 1 2 3 4 5 -2.16 2.16 LOC652383 0.41 1.88 -0.28 -1.24 0.24 1 2 3 4 5 -2.16 2.16 HS.561028 0.51 2.06 -0.09 0.26 -0.45 1 2 3 4 5 -2.16 2.16 TRIM59 0.35 1.53 -0.63 -0.56 -0.50 1 2 3 4 5 -2.16 2.16 LOC649248 0.09 2.11 -0.05 0.97 -0.02 1 2 3 4 5 -2.16 2.16 HS.553132 -0.57 1.48 -0.68 0.09 -0.32 1 2 3 4 5 -2.16 2.16 HS.561383 -0.29 2.11 -0.05 -0.13 -0.27 1 2 3 4 5 -2.16 2.16 HS.542167 1.12 1.65 -0.51 0.16 0.30 1 2 3 4 .5 -2.16 2.16 HS.553176 -0.24 2.25 0.08 0.07 0.14 1 2 3 4 5 -2.16 2.16 Table 3 159 PROL1 -0.44 0.63 -1.54 1.44 -0.49 1 2 3 4 5 -2.17 2.17 HS.563150 -1.13 1.28 -0.88 0.20 0.42 1 2 3 4 5 -2.17 2.17 HS.543837 -0.05 1.74 -0.42 0.34 -0.72 1 2 3 4 5 -2.17 2.17 HS.445589 2.92 2.15 -0.01 6.31 0.84 1 2 3 4 5 -2.17 2.17 HS.581640 0.82 2.52 0.36 0.85 1.34 1 2 3 4 5 -2.17 2.17 HS.564212 0.34 1.79 -0.38 -0.58 -0.56 1 2 3 4 5 -2.17 2.17 LOC642144 1.38 1.88 -0.29 -0.42 -0.51 1 2 3 4 5 -2.17 2.17 HS.580781 1.15 1.60 -0.57 -0.05 0.03 1 2 3 4 5 -2.17 2.17 GAPDHS -0.48 0.96 -1.21 0.74 1.52 1 2 3 4 5 -2.17 2.17 LOC646176 2.95 1.83 -0.34 2.56 0.41 1 2 3 4 5 -2.17 2.17 HS.577963 1.09 0.37 -1.80 2.64 3.70 1 2 3 4 5 -2.17 2.17 HS.537679 -0.35 2.19 0.02 -0.17 -0.23 1 2 3 4 5 -2.17 2.17 HS.563637 -0.08 1.75 -0.42 0.70 -0.54 1 2 3 4 5 -2.17 2.17 HS.402126 1.10 1.62 -0.55 -0.18 0.08 1 2 3 4 5 -2.18 2.18 LOC440864 -0.65 1.75 -0.42 1.96 0.79 1 2 3 4 5 -2.18 2.18 HS.552661 -0.15 2.17 0.00 -0.37 0.31 1 2 3 4 5 -2.18 2.18 HS.561625 -0.14 1.90 -0.28 0.85 -0.07 1 2 3 4 5 -2.18 2.18 HS.170605 -0.61 2.27 0.10 5.04 -0.16 1 2 3 4 5 -2.18 2.18 HS.196011 0.48 1.83 -0.35 -1.19 -0.88 1 2 3 4 5 -2.18 2.18 HS.563438 1.43 2.29 0.11 0.03 1.11 1 2 3 4 5 -2.18 2.18 HS.441354 2.15 1.72 -0.47 0.29 0.31 1 2 3 4 5 -2.18 2.18 OR1S1 -1.04 1.88 -0.31 0.91 3.33 1 2 3 4 5 -2.19 2.19 HS.543800 1.86 2.13 -0.06 1.27 0.06 1 2 3 4 5 -2.19 2.19 LOC644327 -0.36 2.44 0.25 -0.18 0.04 1 2 3 4 5 -2.19 2.19 LOC401447 0.01 1.98 -0.21 0.23 0.35 1 2 3 4 5 -2.19 2.19 LOC645655 -0.25 2.09 -0.10 -0.58 -0.41 1 2 3 4 5 -2.19 2.19 HS.544269 0.40 2.43 0.24 -0.33 -0.30 1 2 3 4 5 -2.19 2.19 HFE2 0.91 1.44 -0.75 2.02 -0.94 1 2 3 4 5 -2.19 2.19 HS.469262 -0.04 0.94 -1.25 -0.48 -0.37 1 2 3 4 5 -2.19 2.19 SLC34A3 -0.45 2.63 0.43 0.30 -0.75 1 2 3 4 5 -2.19 2.19 LOC57399 -0.49 2.40 0.21 1.55 1.06 1 2 3 4 5 -2.19 2.19 MMD2 -1.29 1.93 -0.26 -0.03 -0.91 1 2 3 4 5 -2.19 2.19 HS.213434 -0.74 1.89 -0.30 -0.24 -0.46 1 2 3 4 5 -2.19 2.19 HS.540873 -0.36 2.53 0.34 -0.01 0.29 1 2 3 4 5 -2.19 2.19 HS.555512 -0.04 1.93 -0.26 0.88 0.22 1 2 3 4 5 -2.19 2.19 HS.544171 -0.31 2.11 -0.09 2.01 0.49 1 2 3 4 5 -2.20 2.20 HS.566576 0.10 1.21 -0.99 -0.87 -0.44 1 2 3 4 5 -2.20 2.20 TRPM5 1.12 1.02 -1.18 4.06 -0.35 1 2 3 4 5 -2.20 2.20 HS.542464 0.54 1.83 -0.37 -0.09 -0.62 1 2 3 4 5 -2.20 2.20 HS.537731 0.42 2.00 -0.20 1.42 0.16 1 2 3 4 5 -2.20 2.20 HS.146629 -0.51 1.99 -0.21 1.17 0.21 1 2 3 4 5 -2.20 2.20 HS.132725 0.14 2.30 0.10 -0.37 0.14 1 2 3 4 5 -2.20 2.20 HS.584074 2.22 4.56 2.35 0.92 -0.40 1 2 3 4 5 -2.20 2.20 HS.582233 1.71 1.32 -0.88 1.36 -0.27 1 2 3 4 5 -2.20 2.20 HS.582203 2.49 1.55 -0.66 -0.43 1.03 1 2 3 4 5 -2.20 2.20 HS.539317 2.58 1.67 -0.54 -0.90 -0.31 1 2 3 4 5 -2.20 2.20 KIAA1529 -0.69 0.71 -1.49 0.42 -0.87 1 2 3 4 5 -2.20 2.20 DRGX 1.07 2.77 0.57 0.08 -0.01 1 2 3 4 5 -2.21 2.21 HS.149663 1.12 1.41 -0.80 1.24 -0.70 1 2 3 4 5 -2.21 2.21 Table 3 160 ZSCAN10 -1.10 1.55 -0.66 4.56 2.70 1 2 3 4 5 -2.21 2.21 LOC644225 -0.28 1.68 -0.53 1.09 0.25 1 2 3 4 5 -2.21 2.21 IZUMOl 0.32 1.48 -0.73 -0.03 1.34 1 2 3 4 5 -2.21 2.21 HS.567137 0.52 1.53 -0.68 -1.43 -0.73 1 2 3 4 5 -2.21 2.21 HS.582439 1.12 1.27 -0.95 1.15 2.32 1 2 3 4 5 -2.21 2.21 MYH2 -1.17 1.65 -0.57 5.41 0.77 1 2 3 4 5 -2.21 2.21 TAS2R48 -0.02 2.54 0.33 0.12 -0.14 1 2 3 4 5 -2.21 2.21 HS.500448 -0.08 1.67 -0.55 0.05 0.19 1 2 3 4 5 -2.21 2.21 HS.551204 2.23 2.02 -0.19 0.70 -0.12 1 2 3 4 5 -2.21 2.21 LRRC55 -0.05 3.18 0.97 0.70 1.29 1 2 3 4 5 -2.21 2.21 HS.137068 -0.56 1.58 -0.63 -0.41 0.84 1 2 3 4 5 -2.21 2.21 CDH6 0.51 1.25 -0.97 -0.63 0.15 1 2 3 4 5 -2.22 2.22 HS.252460 -0.45 1.22 -1.00 -0.84 -1.27 1 2 3 4 5 -2.22 2.22 NKD2 -0.10 1.09 -1.12 -0.80 -0.33 1 2 3 4 5 -2.22 2.22 LOC646332 -0.18 1.96 -0.26 -0.25 0.86 1 2 3 4 5 -2.22 2.22 KIAA1772 0.43 3.09 0.87 -0.73 -0.33 1 2 3 4 5 -2.22 2.22 HS.200764 1.31 2.35 0.14 5.32 0.62 1 2 3 4 5 -2.22 2.22 HS.435759 -0.12 1.94 -0.27 -0.18 -0.11 1 2 3 4 5 -2.22 2.22 HS.540068 0.74 1.20 -1.02 0.94 2.03 1 2 3 4 5 -2.22 2.22 HS.298416 1.18 2.50 0.28 0.35 -0.77 1 2 3 4 5 -2.22 2.22 TMEM82 -0.25 2.13 -0.10 -0.29 0.00 1 2 3 4 5 -2.22 2.22 HS.204721 0.72 1.24 -0.98 1.00 1.30 1 2 3 4 5 -2.22 2.22 HS.565003 1.42 1.94 -0.28 0.43 0.69 1 2 3 4 5 -2.22 2.22 LOC390349 -0.10; 1.32 -0.90 -0.24 0.81 1 2 3 4 5 -2.22 2.22 HS.544346 2.70^ 1.90 -0.33 1.20 1.15 1 2 3 4 5 -2.22 2.22 HS.551291 -1.25; 2.80 0.58 -1.03 -1.45 1 2 3 4 5 -2.22 2.22 HS.54707 2.39 2.64 0.41 0.01 0.01 1 2 3 4 5 -2.23 2.23 HS.382663 -0.31 2.91 0.69 0.28 -0.52 1 2 3 4 5 -2.23 2.23 HS.553365 0.48 1.33 -0.90 0.51 1.57 1 2 3 4 5 -2.23 2.23 HS.565482 -0.30 2.04 -0.19 -0.38 -0.32 1 2 3 4 5 -2.23 2.23 HS.543491 1.01 1.24 -0.99 0.26 -0.89 1 2 3 4 5 -2.23 2.23 HS.583388 3.00 2.10 -0.13 0.50 . -0.11 1 2 3 4 5 -2.23 2.23 HS.150750 -0.23 2.29 0.06 0.83 0.43 1 2 3 4 5 -2.23 2.23 TCEAL7 2.13 2.23 -0.01 -0.43 -0.47 1 2 3 4 5 -2.23 2.23 HS.534476 1.74 3.16 0.93 0.26 -0.26 1 2 3 4 5 -2.23 2.23 ZNF70 1.72; 1.25 -0.98 -0.54 -0.47 1 2 3 4 5 -2.24 2.24 PLEKHG4B 5.68 2.00 -0.24 0.60 -1.24 1 2 3 4 5 -2.24 2.24 LOC647844 0.10 1.91 -0.33 0.84 1.64 1 2 3 4 5 -2.24 2.24 HS.560885 2.06 1.66 -0.58 0.59 0.22 1 2 3 4 5 -2.24 2.24 HS.544912 1.39 1.91 -0.33 0.40 -0.01 1 2 3 4 5 -2.24 2.24 LOC653166 2.36 2.01 -0.23 0.08 0.86 1 2 3 4 5 -2.24 2.24 TTTY20 0.94 2.07 -0.17 -0.58 -0.45 1 2 3 4 5 -2.24 2.24 LOC650851 -0.12 1.65 -0.59 -0.09 0.36 1 2 3 4 5 -2.24 2.24 MRGPRX4 -0.53 1.98 -0.26 3.62 0.02 1 2 3 4 5 -2.24 2.24 LOC644285 0.04 1.46 -0.78 -0.08 0.24 1 2 3 4 5 -2.24 2.24 HS.563556 0.35 1.83 -0.41 -0.14 -0.27 1 2 3 4 5 -2.24 2.24 LOC653606 0.32 2.03 -0.22 0.16 -0.10 1 2 3 4 5 -2.24 2.24 HS.540683 1.69 0.85 -1.40 -0.23 0.11 1 2 3 4 5 -2.25 2.25 HS.551418 1.20 1.82 -0.43 0.27 0.32 1 2 3 4 5 -2.25 2.25 Table 3 161 HS.375820 3.09 0.48 -1.77 2.22 -0.42 1 2 3 4 5 -2.25 2.25 HS.534096 -0.29 1.75 -0.50 -0.65 0.04 1 2 3 4 5 -2.25 2.25 HS.542309 4.23 4.21 1.97 3.73 3.03 1 2 3 4 5 -2.25 2.25 HS.543396 0.05 2.79 0.55 0.29 1.33 1 2 3 4 5 -2.25 2.25 HS.540255 -0.07 1.83 -0.42 0.49 0.19 1 2 3 4 5 -2.25 2.25 HS.147574 0.62 2.17 -0.08 1.60 1.04 1 2 3 4 5 -2.25 2.25 HS.156918 1.08 1.73 -0.52 -0.93 1.14 1 2 3 4 -2.25 2.25 MUC7 -0.18 1.08 -1.17 -0.78 -1.57 1 2 3 4 5 -2.25 2.25 SNORD108 6.10 2.81 0.55 0.34 0.01 1 2 3 4 5 -2.25 2.25 HS.323590 -0.28 2.05 -0.21 0.52 3.11 1 2 3 4 5 -2.25 2.25 LOC647836 -0.58 2.25 0.00 -0.85 0.29 1 2 3 4 5 -2.25 2.25 LOC653092 0.89 2.02 -0.23 2.27 0.79 1 2 3 4 5 -2.26 2.26 HS.538854 -0.30 1.59 -0.67 -0.65 -0.20 1 2 3 4 5 -2.26 2.26 HS.577002 -0.53 3.03 0.77 -0.14 -0.11 1 2 3 4 5 -2.26 2.26 HS.544019 2.29 2.18 -0.08 0.23 1.38 1 2 3 4 5 -2.26 2.26 HS.45247 -0.02 1.71 -0.55 0.90 -0.57 1 2 3 4 5 -2.26 2.26 HS.147763 0.09 1.74 -0.52 -0.83 -0.72 1 2 3 4 5 -2.26 2.26 HS.224985 0.56 1.73 -0.54 1.72 0.63 1 2 3 4 5 -2.26 2.26 FBXL22 0.57 1.49 -0.78 1.01 -0.36 1 2 3 4 5 -2.26 2.26 HS.177943 4.59 1.33 -0.94 -0.62 0.44 1 2 3 4 5 -2.27 2.27 LOC643496 0.43 1.77 -0.50 0.98 1.00 1 2 3 4 5 -2.27 2.27 HS.542152 4.91 2.71 0.44 -0.61 1.36 1 2 3 4 5 -2.27 2.27 HS.570866 -0.13 2.15 -0.12 -0.44 0.56 1 2 3 4 5 -2.27 2.27 RASGRF2 0.05 2.53 0.26 0.58 0.86 1 2 3 4 5 -2.27 2.27 HS.385619 0.37 2.42 0.15 0.97 -0.01 1 2 3 4 5 -2.27 2.27 PCDHGA8 4.18 1.95 -0.31 0.42 -0.69 1 2 3 4 5 -2.27 2.27 HS.581323 -0.30 3.40 1.13 0.05 0.10 1 2 3 4 5 -2.27 2.27 HS.430589 -0.15 2.10 -0.16* -0.22 -0.16 1 2 3 4 5 -2.27 2.27 SERPINA9 -0.21 1.45 -0.82 -0.24 0.72 1 2 3 4 5 -2.27 2.27 LOC642460 -1.47 ; 1.38 -0.89 0.18 -1.43 1 2 3 4 5 -2.27 2.27 ZNF645 -1.20 ' 2.12 -0.15 0.87 1.07 1 2 3 4 5 -2.27 2.27 FU43505 -0.26 2.16 -0.11 -0.21 0.11 1 2 3 4 5 -2.27 2.27 SCIN -0.04 1.31 -0.96 1.34 -0.70 1 2 3 4 5 -2.27 2.27 LOC653894 0.24 1.78 -0.49 0.17 0.60 1 2 3 4 5 -2.27 2.27 NKX6-2 0.18 2.53 0.26 -0.38 -0.23 1 2 3 4 5 -2.28 2.28 HS.570286 2.44 1.98 -0.30 -0.11 0.99 1 2 3 4 5 -2.28 2.28 LOC731714 -0.56 1.93 -0.35 0.04 -0.61 1 2 3 4 5 -2.28 2.28 RASAL2 0.05 1.39 -0.89 0.77 0.58 1 2 3 4 5 -2.28 2.28 0R1L1 -0.87 1.37 -0.92 -0.90 -1.16 1 2 3 4 5 -2.28 2.28 HS.554401 1.18 2.71 0.42 3.08 2.20 1 2 3 4 5 -2.28 2.28 HS.136907 -1.29 2.72 0.43 0.56 -0.45 1 2 3 4 5 -2.28 2.28 KIAA0738 -0.20 1.74 -0.54 -0.89 0.17 1 2 3 4 ' 5 -2.29 2.29 HS.583341 3.37 1.77 -0.52 0.66 1.45 1 2 3 4 5 -2.29 2.29 HS.554645 -1.30 1.87 -0.42 2.05 1.26 1 2 3 4 5 -2.29 2.29 HS.539332 1.95 1.41 -0.88 0.15 -0.93 1 2 3 4 5 -2.29 2.29 HS.171270 -0.58 -0.57 -2.86 -0.37 -1.75 1 2 3 4 5 -2.29 2.29 HS.63311 0.14 2.33 0.04 -0.06 0.10 1 2 3 4 5 -2.29 2.29 LOC653547 -0.28 2.49 0.20 -0.57 0.26 1 2 3 4 5 -2.29 2.29 FBX027 3.14 1.42 -0.87 -0.10 -1.09 1 2 3 4 5 -2.29 2.29 Table 3 162

HS.568406 1.44 1.26 -1.03 -0.15 -0.72 1 2 3 4 5 -2.29 2.29 HS.582529 -1.39 0.57 -1.72 5.22 0.09 1 2 3 4 5 -2.29 2.29 HS.577908 -0.95 1.81 -0.48 0.05 -0.58 1 2 3 4 5 -2.29 2.29 HS.580096 -0.14 3.28 0.99 -0.74 -0.03 1 2 3 4 5 -2.29 2.29 LOC340260 -0.53 2.34 0.04 0.07 0.16 1 2 3 4 5 -2.30 2.30 HS.568789 0.14 1.73 -0.57 -1.38 1.74 1 2 3 4 5 -2.30 2.30 PDZK3 -0.26 2.85 0.55 -0.24 -0.07 1 2 3 4 5 -2.30 2.30 HS.298335 0.96 2.69 0.39 -0.72 0.18 1 2 3 4 5 -2.30 2.30 LOC647193 0.10 2.83 0.53 0.44 -0.87 1 2 3 4 5 -2.30 2.30 HS.554431 1.27 2.14 -0.16 1.85 0.14 1 2 3 4 5 -2.30 2.30 LOC645797 -0.32 1.52 -0.78 1.59 -0.30 1 2 3 4 5 -2.30 2.30 HS.552996 -0.11 1.51 -0.79 0.77 -0.05 1 2 3 4 5 -2.30 2.30 HS.566417 0.09 2.16 -0.15 -0.19 -0.07 1 2 3 4 5 -2.30 2.30 REP15 2.48 2.52 0.21 0.80 0.24 1 2 3 4 5 -2.30 2.30

OGN -1.05' 1.72 -0.59 -1.68 -1.36 1 2 3 4 5 -2.31 2.31 OR5T2 -0.03 0.89 -1.42 0.95 -1.36 1 2 3 4 5 -2.31 2.31 HS.382684 -0.84 1.69 -0.62 -0.20 -0.65 1 2 3 4 5 -2.31 2.31 HS.518442 -0.16 1.50 -0.82 -0.70 -0.51 1 2 3 4 5 -2.31 2.31 HS.46879 1.00 2.24 -0.07 -0.27 0.70 1 2 3 4 5 -2.31 2.31 HS.381884 2.65 2.03 -0.28 0.34 0.29 1 2 3 4 5 -2.31 2.31 SNAI1 -0.84 4.02 1.70 1.50 0.92 1 2 3 4 5 -2.31 2.31 HS.376067 0.20 2.25 -0.07 -1.29 0.91 1 2 3 4 5 -2.31 2.31 LOC653883 -0.15 1.84 -0.47 2.04 0.12 1 2 3 4 5 -2.32 2.32 LOC653483 1.24 1.91 -0.40 4.05 0.40 1 2 3 4 5 -2.32 2.32 HS.544832 -0.44 2.12 -0.20 3.39 0.10 1 2 3 4 5 -2.32 2.32 HS.553291 -0.14 2.23 -0.09 -0.12 -0.19 1 2 3 4 5 -2.32 2.32 LOC650887 0.08 3.12 0.80 0.20 0.86 1 2 3 4 5 -2.32 2.32 TTTY13 -0.18 0.78 -1.54 -0.59 2.55 1 2 3 4 5 -2.32 2.32 LOC646589 0.42 2.73 0.41 1.01 0.37 1 2 3 4 5 -2.32 2.32 LOC642718 1.02 1.91 -0.41 -0.42 1.30 1 2 3 4 5 -2.33 2.33 LOC645971 5.35 3.09 0.76 -0.33 -0.51 1 2 3 4 5 -2.33 2.33 CATSPER4 0.08 1.59 -0.74 0.30 0.41 1 2 3 4 5 -2.33 2.33 HS.574126 3.66 1.04 -1.28 1.20 0.62 1 2 3 4 5 -2.33 2.33 CXORF30 2.04 2.70 0.38 4.05 -0.11 1 2 3 4 5 -2.33 2.33 LOC388002 0.13 3.40 1.07 1.01 1.72 1 2 3 4 5 -2.33 2.33 HS.545232 -0.03 2.31 -0.02 0.00 -0.01 1 2 3 4 5 -2.33 2.33 LOC652757 2.37 1.44 -0.90 -0.12 0.87 1 2 3 4 5 -2.33 2.33 HS.202033 0.30 1.76 -0.57 5.64 0.00 1 2 3 4 5 -2.33 2.33 KRTAP24-1 0.03 3.76 1.43 -0.42 -0.14 1 2 3 4 5 -2.33 2.33 HS.542478 -0.62 2.00 -0.33 5.73 -1.02 1 2 3 4 5 -2.34 2.34 HS.539972 1.05 1.58 -0.75 1.12 -0.69 1 2 3 4 5 -2.34 2.34 LOC642220 0.27 2.24 -0.10 0.26 0.96 1 2 3 4 5 -2.34 2.34 C110RF34 -0.45 1.87 -0.47 -0.05 0.01 1 2 3 4 5 -2.34 2.34 LOC645781 -0.99 0.99 -1.35 -1.41 -0.55 1 2 3 4 5 -2.34 2.34 HS.97457 0.61 1.87 -0.47 -1.25 1.23 1 2 3 4 5 -2.34 2.34 HS.540116 -0.12 2.86 0.52 -0.42 -0.39 1 2 3 4 5 -2.34 2.34 HS.113170 1.33 1.24 -1.11 2.26 1.56 1 2 3 4 5 -2.34 2.34 HS.560471 -0.03 2.86 0.51 1.74 -0.47 1 2 3 4 5 -2.35 2.35 HS.245002 -0.50 1.31 -1.04 0.66 -0.76 1 2 3 4 5 -2.35 2.35 Table 3 163 HS.410729 0.72 1.91 -0.44 2.01 -0.56 1 2 3 4 5 -2.35 2.35 CFHR4 -0.83 2.30 -0.05 -0.04 -1.57 1 2 3 4 5 -2.35 2.35 HS.584501 -0.23 2.08 -0.27 1.65 1.37 1 2 3 4 5 ; -2.35 2.35 DOK5 4.32 1.59 -0.77 -0.96 3.61 1 2 3 4 -2.35 2.35 HS.563999 0.56 3.22 0.87 1.57 2.53 1 2 3 4 -2.35 2.35 HS.147846 0.55 2.51 0.16 0.71 0.59 1 2 3 4 5 -2.35 2.35 HS.580466 0.16 2.64 0.29 0.38 -0.03 1 2 3 4 5 -2.35 2.35 OFCC1 0.88 2.00 -0.36 -0.27 -1.38 1 2 3 4 5 -2.35 2.35 HS.579593 -0.35 1.45 -0.91 -0.22 0.48 1 2 3 4 5 -2.36 2.36 LOC651830 0.52 1.22 -1.14 4.21 -0.16 1 2 3 4 5 -2.36 2.36 HS.583827 -0.04 2.90 0.53 -1.12 0.32 1 2 3 4 5 -2.36 2.36 HS.553119 0.15 3.86 1.49 0.96 -0.25 1 2 3 4 5 -2.36 2.36 HS.541003 0.18 3.55 1.18 0.19 -0.37 1 2 3 4 5 -2.37 2.37 HS.205112 0.79 2.00 -0.37 1.95 -0.38 1 2 3 4 5 -2.37 2.37 HS.369398 -0.29 1.65 -0.72 1.38 0.46 1 2 3 4 5 -2.37 2.37 HS.543618 1.06 2.18 -0.19 0.20 0.12 1 2 3 4 5 -2.37 2.37 HAND1 0.93 1.81 -0.56 0.31 0.95 1 2 3 4 5 -2.37 2.37 LOC643467 0.37 2.18 -0.19 -0.25 -0.08 1 2 3 4 5 -2.37 2.37 HS.546147 0.23 2.32 -0.05 -0.39 -0.44 1 2 3 4 5 -2.37 2.37 HS.576630 0.32 2.46 0.09 -0.04 0.44 1 2 3 4 5 -2.37 2.37 HS.131365 4.38 2.07 -0.31 3.10 6.46 1 2 3 4 5 -2.38 2.38 FU25037 2.37 1.86 -0.52 -0.33 0.36 1 2 3 4 5 -2.38 2.38 LOC345051 -0.20 2.37 -0.01 -0.01 -0.36 1 2 3 4 5 -2.38 2.38 KHDRBS2 -0.65 3.58 1.19 1.09 -0.13 1 2 3 4 5 -2.38 2.38 MAPT 0.17 2.09 -0.30 -0.26 -0.80 1 2 3 4 5 -2.38 2.38 HS.566927 2.64 2.14 -0.25 -0.36 -0.73 1 2 3 4 5 -2.38 2.38 LOC652153 -0.61 1.75 -0.63 0.42 -0.25 1 2 3 4 5 -2.39 2.39 HS.560644 0.22 1.51 -0.88 -0.17 1.72 1 2 3 4 5 -2.39 2.39 LOC651711 2.92 ; 1.48 -0.91 0.19 0.82 1 2 3 4 -2.39 2.39 HS.579259 -0.59 2.00 -0.39 0.46 0.47 1 2 3 4 -2.39 2.39 HS.569848 -1.18 1.79 -0.60 2.31 -0.18 1 2 3 4 -2.39 2.39 LOC652880 -0.30 1.61 -0.78 -0.22 0.89 1 2 3 4 5 -2.39 2.39 HS.566194 0.50 2.85 0.46 -0.79 0.39 1 2 3 4 5 -2.39 2.39 LOC650418 0.39 2.60 0.20 0.24 1.22 1 2 3 4 5 -2.40 2.40 LOC647447 -0.30 1.59 -0.81 0.58 0.30 1 2 3 4 5 -2.40 2.40 HS.538167 -0.53 3.24 0.84 -0.52 0.80 1 2 3 4 5 -2.40 2.40 CACNG2 -0.65 2.51 0.10 -0.98 1.44 1 2 3 4 5 -2.40 2.40 HS.162010 0.99 2.47 0.07 -0.62 0.47 1 2 3 4 5 -2.40 2.40 LOC644912 4.45 2.45 0.05 1.82 2.87 1 2 3 4 5 -2.40 2.40 KRTAP5-10 0.86 2.14 -0.26 -0.69 0.00 1 2 3 4 5 -2.40 2.40 PYY -0.24 2.62 0.22 2.16 0.09 1 2 3 4 5 -2.40 2.40 BCAR1 ' -0.40 2.36 -0.04 0.58 -0.33 1 2 3 4 5 -2.40 2.40 HS.579392 2.34 1.33 -1.08 0.50 2.19 1 2 3 4 5 -2.40 2.40 HS.570693 -0.29 1.76 -0.64 0.06 1.98 1 2 3 4 5 -2.41 2.41 HS.581994 0.05 3.33 0.92 1.56 0.08 1 2 3 4 5 -2.41 2.41 HS.552332 -0.18 2.53 0.12 0.12 -0.41 1 2 3 4 5 -2.41 2.41 HS.578332 0.81 1.68 -0.73 0.37 -0.36 1 2 3 4 5 -2.41 2.41 STRA6 2.05 2.12 -0.30 -0.18 1.98 1 2 3 4 5 -2.41 2.41 HS.545870 1.98 2.39 -0.03 1.80 1.07 1 2 3 4 5 -2.41 2.41 Table 3 164 OR8S1 1.44 2.63 0.22 1.42 -1.11 1 2 3 4 5 -2.41 2.41 CHRDL1 -0.16 3.47 1.05 -1.09 0.14 1 2 3 4 5 -2.42 2.42 IQCD -0.03 1.71 -0.71 -1.33 3.20 1 2 3 4 5 -2.42 2.42 HS.403766 1.34 2.05 -0.37 0.57 -0.51 1 2 3 4 5 -2.42 2.42 HS.563387 0.17 2.42 0.00 -0.39 -0.27 1 2 3 4 5 -2.42 2.42 LOC649963 1.55 2.09 -0.33 -0.12 0.09 1 2 3 4 5 -2.42 2.42 SMR3A -0.08 1.91 -0.51 -0.56 0.65 1 2 3 4 5 -2.42 2.42 PSG1 0.33 1.53 -0.89 1.09 -0.17 1 2 3 4 5 -2.42 2.42 HS.543700 -0.09 2.13 -0.30 1.64 0.12 1 2 3 4 5 -2.43 2.43 HS.539124 1.38 1.67 -0.76 -0.23 0.65 1 2 3 4 5 -2.43 2.43 HS.555566 1.14 1.39 -1.04 -1.72 -0.52 1 2 3 4 5 -2.43 2.43 HS.128031 -0.67 2.37 -0.06 0.34 0.22 1 2 3 4 5 -2.43 2.43 LHB 0.58 1.65 -0.79 0.05 -0.54 1 2 3 4 5 -2.44 2.44 LOC653920 -1.08 1.78 -0.66 -1.17 2.43 1 2 3 4 5 -2.44 2.44 HS.274276 2.68 1.49 -0.96 -0.61 3.37 1 2 3 4 5 -2.45 2.45 HS.161998 2.03 3.12 0.67 0.36 -0.41 1 2 3 4 5 -2.45 2.45 HS.583392 -0.11 2.44 -0.01 1.14 -0.27 1 2 3 4 5 -2.45 2.45 HS.515322 0.27 3.70 1.25 -1.17 -1.06 1 2 3 4 5 -2.45 2.45 HS.570981 -0.07 2.77 0.32 -0.27 0.29 1 2 3 4 5 -2.45 2.45 GIPR 0.67 1.30 -1.15 -0.35 -0.68 1 2 3 4 5 -2.45 2.45 HS.553015 -0.21 2.36 -0.09 -0.14 1.40 1 2 3 4 5 -2.45 2.45 LOC651319 -0.11 1.78 -0.67 -0.19 0.37 1 2 3 4 5 -2.45 2.45 HS.537829 -0.47 3.23 0.77 0.25 -0.50 1 2 3 4 5 -2.45 2.45 HMGCLL1 2.16 1.68 -0.77 0.18 0.95 1 2 3 4 5 -2.45 2.45 HS.565913 0.22 1.85 -0.60 0.23 0.31 1 2 3 4 5 -2.45 2.45 HS.581434 0.67 2.44 -0.01 0.26 1.59 1 2 3 4 5 -2.45 2.45 HS.545542 -0.81 1.45 -1.01 -1.35 -0.96 1 2 3 4 5 -2.46 2.46 HS.158961 0.30 1.93 -0.53 -0.76 -1.31 1 2 3 4 5 -2.46 2.46 HS.507018 1.31 2.51 0.05 1.98 1.05 1 2 3 4 5 -2.46 2.46 LOC642111 3.16 2.63 0.17 4.16 0.02 1 2 3 4 5 -2.46 2.46 H0XD9 0.11 2.83 0.37 0.65 0.10 1 2 3 4 5 -2.46 2.46 C110RF52 1.21 2.54 0.07 -0.30 -0.85 1 2 3 4 5 -2.47 2.47 HS.565789 -0.58 2.51 0.04 0.23 -0.37 1 2 3 4 5 -2.47 2.47 HS.544094 0.98 1.48 -0.99 -0.52 2.34 1 2 3 4 5 -2.47 2.47 HS.333528 -0.84 2.22 -0.26 -1.03 -1.00 1 2 3 4 5 -2.47 2.47 HS.564476 1.81 2.84 0.37 0.44 0.18 1 2 3 4 5 -2.48 2.48 HS.559406 1.64 2.36 -0.12 -1.18 0.71 1 2 3 4 5 -2.48 2.48 LOC652517 -1.09 2.60 0.12 -0.14 3.69 1 2 3 4 5 -2.48 2.48 HS.552741 -0.38 2.23 -0.26 -0.32 -0.28 1 2 3 4 5 -2.48 2.48 HS.145426 2.70 1.60 -0.88 0.63 0.32 1 2 3 4 5 -2.48 2.48 LOC644569 -1.34 2.44 -0.04 2.18 -1.10 1 2 3 4 5 -2.48 2.48 LOC647281 -0.06 2.13 -0.35 2.64 2.97 1 2 3 4 5 -2.48 2.48 LOC643435 -0.59 3.07 0.59 -0.69 -0.10 1 2 3 4 5 -2.48 2.48 HS.562114 -1.30 2.73 0.24 0.04 -0.24 1 2 3 4 5 -2.48 2.48 HS.566224 -0.65 1.67 -0.81 -0.14 0.67 1 2 3 4 . 5 -2.49 2.49 LOC441617 0.52 2.36 -0.13 -0.28 0.32 1 2 3 4 5 -2.49 2.49 HS.543757 2.94 2.41 -0.08 0.02 0.07 1 2 3 4 5 -2.49 2.49 ADAMTS2 1.90 0.90 -1.59 -0.97 1.52 1 2 3 4 5 -2.49 2.49 PARTI -0.71 1.70 -0.80 1.47 -0.68 1 2 3 4 5 -2.49 2.49 Table 3 165 KIF12 0.20 1.85 -0.65 -0.47 0.57 1 2 3 4 5 -2.49 2.49 HS.562259 0.91 2.09 -0.40 2.96 -0.77 1 2 3 4 5 -2.49 2.49 HS.446028 2.14 1.72 -0.78 0.49 0.59 1 2 3 4 5 -2.50 2.50 HS.578947 1.25 3.73 1.24 2.40 0.28 1 2 3 4 5 -2.50 2.50 HS.583057 0.69 2.63 0.13 1.32 0.99 1 2 3 4 5 -2.50 2.50 HS.233134 -0.09 2.42 -0.07 -0.05 -0.20 1 2 3 4 5 -2.50 2.50 HS.98273 -0.73 2.24 -0.26 0.15 0.06 1 2 3 4 5 -2.50 2.50 HS.562122 2.04 2.75 0.25 -0.28 0.41 1 2 3 4 5 -2.50 2.50 LOC650407 -0.97 2.01 -0.50 1.05 4.29 1 2 3 4 5 -2.50 2.50 DGAT2L6 0.82 2.08 -0.42 -0.60 1.05 1 2 3 4 5 -2.50 2.50 HS.543076 -0.37 2.31 -0.20 -0.01 -0.01 1 2 3 4 5 -2.51 2.51 SNORD107 1.17 1.41 -1.09 1.28 0.86 1 2 3 4 5 -2.51 2.51 LOC642383 1.64 3.34 0.83 0.60 0.64 1 2 3 4 5 -2.51 2.51 LOC645450 0.16 1.66 -0.85 -0.03 1.54 1 2 3 4 5 -2.51 2.51 WNT11 0.81 2.31 -0.21 0.12 0.54 1 2 3 4 5 -2.52 2.52 HS.541490 0.35 2.38 -0.14 -0.34 -0.25 1 2 3 4 5 -2.52 2.52 HS.210273 0.98 1.83 -0.69 0.44 0.34 1 2 3 4 5 -2.52 2.52 PLCH1 -0.20 2.60 0.09 -0.46 -0.40 1 2 3 4 5 -2.52 2.52 HS.207105 0.03 1.91 -0.61 5.02 -0.93 1 2 3 4 5 -2.52 2.52 LOC649527 2.93 1.70 -0.82 -0.77 0.76 1 2 3 4 5 -2.52 2.52 HS.545082 -0.62; 2.46 -0.06 1.36 0.33 1 2 3 4 5 -2.52 2.52 HS.528280 2.03 1.81 -0.71 1.84 -0.34 1 2 3 4 5 -2.52 2.52 HS.582854 0.50 5.05 2.53 0.15 -0.61 1 2 3 4 5 -2.52 2.52 TAT -0.71 1.85 -0.68 -0.74 -0.16 1 2 3 4 5 -2.52 2.52 PRAMEF1 4.94 2.26 -0.27 0.35 0.08 1 2 3 4 5 -2.53 2.53 ECEL1 0.74 2.06 -0.47 0.91 -0.10 1 2 3 4 5 -2.53 2.53 HS.7004 0.00 2.77 0.24 0.26 0.34 1 2 3 4 5 -2.53 2.53 HS.562347 -0.50 3.71 1.18 3.55 -1.26 1 2 3 4 5 -2.53 2.53 HS.545402 -0.71 3.75 1.22 0.14 2.35 1 2 3 4 5 -2.53 2.53 CASRL1 -0.50, 2.72 0.19 5.34 -0.54 1 2 3 4 5 -2.53 2.53 HS.543654 -0.68 2.46 -0.07 0.20 -0.36 1 2 3 4 5 -2.53 2.53 TTLL10 0.62 1.96 -0.57 1.40 -1.38 1 2 3 4 5 -2.53 2.53 FAM26A 2.07 3.14 0.61 1.78 1.60 1 2 3 4 5 -2.53 2.53 LOC120364 -0.20 2.39 -0.14 -0.22 0.35 1 2 3 4 5 -2.53 2.53 HS.274878 0.27 2.10 -0.44 -0.03 2.98 1 2 3 4 5 -2.53 2.53 HS.545241 2.27 1.34 -1.20 -0.22 2.19 1 2 3 4 5 -2.54 2.54 HS.544495 0.06 2.13 -0.41 0.04 0.42 1 2 3 4 5 -2.54 2.54 LOC652688 1.28 2.33 -0.21 1.07 -0.12 1 2 3 4 5 -2.54 2.54 LOC392559 -0.73 2.60 0.06 0.69 1.72 1 2 3 4 5 -2.54 2.54 OR4C15 -0.42 2.63 0.09 -0.28 0.04 1 2 3 4 5 -2.54 2.54 LOC652469 -0.70; 3.43 0.89 1.70 2.82 1 2 3 4 5 -2.54 2.54 FU42280 -1.13 3.87 1.33 -0.21 1.35 1 2 3 4 5 -2.54 2.54 HS.552808 -0.62 4.80 2.25 -0.30 -1.09 1 2 3 4 5 -2.54 2.54 RUNDC3A 1.63 3.23 0.69 0.59 -1.03 1 2 3 4 5 -2.54 2.54 HS.568648 -0.25 1.96 -0.58 1.18 3.77 1 2 3 4 5 -2.55 2.55 FGF22 0.16; 1.80 -0.75 -1.11 0.65 1 2 3 4 5 -2.55 2.55 HS.575486 -1.82 3.20 0.65 0.56 -0.10 1 2 3 4 5 -2.55 2.55 HS.518418 -1.55 4.29 1.73 2.36 2.66 1 2 3 4 5 -2.56 2.56 HS.570848 0.38 2.89 0.33 -0.01 1.84 1 2 3 4 5 -2.56 2.56 Table 3 166 HS.582229 -0.42 2.07 -0.49 -0.60 1.87 1 2 3 4 5 -2.56 2.56 KU-MEL-3 0.44 2.50 -0.06 1.44 1.21 1 2 3 4 5 -2.56 2.56 LOC643258 1.03 3.08 0.52 1.26 0.83 1 2 3 4 5 -2.56 2.56 CACNA1E 2.97 1.72 -0.84 -0.21 -0.40 1 2 3 4 5 -2.56 2.56 HS.537606 -0.42 2.35 -0.22 2.98 1.72 1 2 3 4 5 -2.57 2.57 F M PD2 0.25 2.93 0.36 0.14 0.61 1 2 3 4 5 -2.57 2.57 HS.577942 0.11 2.41 -0.16 -0.11 0.04 1 2 3 4 5 -2.57 2.57 LOC651513 -1.17 2.02 -0.55 0.18 -0.46 1 2 3 4 5 -2.57 2.57 HS.543346 0.16 2.25 -0.32 -0.35 -0.15 1 2 3 4 5 -2.57 2.57 HS.566210 0.15 1.90 -0.68 -0.96 -0.91 1 2 3 4 5 -2.57 2.57 HS.582742 1.02 1.93 -0.64 0.00 1.72 1 2 3 4 5 -2.57 2.57 HS.580557 -0.38 2.30 -0.27 1.87 1.50 1 2 3 4 5 -2.57 2.57 LOC649784 0.61 1.78 -0.79 -0.99 -0.58 1 2 3 4 5 -2.57 2.57 HS.564964 -0.36 1.89 -0.69 -0.53 1.95 1 2 3 4 5 -2.58 2.58 HS.207546 -0.12 3.07 0.49 -0.48 1.05 1 2 3 4 5 -2.58 2.58 HS.578112 -0.90 1.89 -0.68 -0.97 0.32 1 2 3 4 5 -2.58 2.58 HS.200096 0.80 2.40 -0.18 1.95 -0.54 1 2 3 4 5 -2.58 2.58 TTC6 1.15 4.50 1.92 0.83 2.21 1 2 3 4 5 -2.58 2.58 HS.535454 0 0 3.35 0.77 -0.19 0.31 1 2 3 4 5 -2.58 2.58 LOC652009 1.95 1.39 -1.19 0.98 1.05 1 2 3 4 5 -2.58 2.58 HS.544068 -1.09 1.35 -1.23 -0.63 0.26 1 2 3 4 5 -2.58 2.58 HS.164254 -0.36 2.29 -0.30 0.58 0.76 1 2 3 4 5 -2.58 2.58 LOC651921 3.18 1.85 -0.73 -0.35 -0.37 1 2 3 4 5 -2.58 2.58 HS.577416 0.26i 2.84 0.26 -0.29 -0.08 1 2 3 4 5 -2.58 2.58 HS.539026 0.98 2.39 -0.20 0.02 3.53 1 2 3 4 5 -2.58 2.58 HS.106359 0.30 2.33 -0.25 -0.17 -0.19 1 2 3 4 5 -2.59 2.59 HS.253993 0.16 1.50 -1.08 0.96 0.18 1 2 3 4 5 -2.59 2.59 HS.519234 0.81; 1.56 -1.03 0.70 0.18 1 2 3 4 5 -2.59 2.59 HS.566023 -0.51 3.51 0.92 0.22 -0.22 1 2 3 4 5 -2.59 2.59 GABRQ 0.85 3.18 0.58 -1.54 1.71 1 2 3 4 5 -2.59 2.59 HS.183974 0.17 2.30 -0.30 2.69 1.23 1 2 3 4 5 -2.59 2.59 HS.539256 0.23 1.77 -0.82 0.67 0.98 1 2 3 4 5 -2.59 2.59 RGPD5 -0.29 2.31 -0.28 2.42 0.20 1 2 3 4 5 -2.60 2.60 LOC642424 -0.70 1.82 -0.78 -0.37 -0.68 1 2 3 4 5 -2.60 2.60 HS.508690 1.49 2.13 -0.47 0.64 0.31 1 2 3 4 5 -2.60 2.60 HS.562223 0.09 1.97 -0.63 0.44 -0.48 1 2 3 4 5 -2.60 2.60 HS.562350 1.87 2.04 -0.56 -0.45 -0.12 1 2 3 4 5 -2.60 2.60 ARMC4 -0.97 1.84 -0.76 -0.01 -1.34 1 2 3 4 5 -2.61 2.61 HS.363212 1.71 1.73 -0.87 0.24 1.06 1 2 3 4 5 -2.61 2.61 TNNI1 5.37 2.03 -0.58 3.37 1.12 1 2 3 4 5 -2.61 2.61 HS.281924 0.29 2.15 -0.47 -0.54 0.62 1 2 3 4 5 -2.61 2.61 LOC645929 1.19 0.80 -1.81 -1.04 -0.49 1 2 3 4 5 -2.61 2.61 ASCL3 0.92 2.25 -0.36 -0.10 -0.12 1 2 3 4 5 -2.61 2.61 HS.545234 -0.11 2.49 -0.12 0.17 -0.01 1 2 3 4 5 -2.62 2.62 HS.541030 0.60 1.88 -0.74 0.45 1.65 1 2 3 4 5 -2.62 2.62 HS.229512 -0.08 1.88 -0.74 -0.15 -0.30 1 2 3 4 5 -2.62 2.62 TXLNB 0.47 2.24 -0.38 0.50 0.64 1 2 3 4 5 -2.62 2.62 HS.539016 2.34 1.52 -1.10 1.71 0.39 1 2 3 4 5 -2.62 2.62 HS.23777 -1.43 1.75 -0.87 0.12 1.79 1 2 3 4 5 -2.62 2.62 Table 3 167 LOC649937 0.67 2.03 -0.60 0.19 -0.16 1 2 3 4 5 -2.62 2.62 C210RF114 1.73 2.82 0.19 0.83 -0.05 1 2 3 4 5 -2.63 2.63 HS.537838 0.10 1.02 -1.61 0.06 0.44 1 2 3 4 5 -2.63 2.63 SHANK1 -0.61 ; 2.22 -0.41 0.07 -0.84 1 2 3 4 5 -2.63 2.63 LOC643962 0.99 1.74 -0.90 -0.29 1.14 1 2 3 4 5 -2.63 2.63 LOC652435 -0.51 2.14 -0.49 -0.40 0.95 1 2 3 4 5 -2.63 2.63 C10RF99 -0.05 1.84 -0.79 -0.25 -0.39 1 2 3 4 5 -2.63 2.63 C10RF141 -0.69 1.99 -0.64 0.06 -0.40 1 2 3 4 5 -2.63 2.63 TFAP2C -0.59 2.54 -0.10 5.66 1.16 1 2 3 4 5 -2.63 2.63 GPR137C 0.75 2.03 -0.61 -0.16 -0.54 1 2 3 4 5 -2.63 2.63 TBC1D29 -0.91 2.91 0.27 -0.72 0.27 1 2 3 4 5 -2.63 2.63 PCDHGA4 -1.48 1.21 -1.42 4.49 -1.06 1 2 3 4 5 -2.64 2.64 HS.540519 1.02 1.41 -1.23 0.25 0.14 1 2 3 4 5 -2.64 2.64 LOC646625 -0.61 1.48 -1.16 1.94 0.07 1 2 3 4 5 -2.64 2.64 HS.552549 -0.80 2.21 -0.43 5.53 0.75 1 2 3 4 5 -2.64 2.64 HS.550218 -0.18 2.45 -0.19 0.03 -0.16 1 2 3 4 5 -2.64 2.64 IPOL1 -0.10 2.22 -0.43 0.59 0.64 1 2 3 4 5 -2.65 2.65 CEP170L 5.57 2.37 -0.28 0.82 0.57 1 2 3 4 5 -2.65 2.65 HS.565092 0.30 2.44 -0.21 0.10 -0.16 1 2 3 4 5 -2.65 2.65 LOC644151 0.00 3.20 0.55 0.24 -0.05 1 2 3 4 5 -2.65 2.65 HS.518794 0.52 1.91 -0.74 0.80 -0.14 1 2 3 4 5 -2.65 2.65 LOC642147 -0.72 2.07 -0.58 0.08 -1.49 1 2 3 4 5 -2.66 2.66 FAM83G -0.78 1.98 -0.67 -0.53 0.09 1 2 3 4 5 : -2.66 2.66 LOC647096 1.76 3.26 0.60 1.29 0.21 1 2 3 4 5 -2.66 2.66 HS.571164 0.24 1.78 -0.88 -0.81 -0.52 1 2 3 4 5 -2.66 2.66 HS.541808 -0.33 , 2.25 -0.41 -0.16 -0.14 1 2 3 4 5 -2.66 2.66 HS.211087 1.38 2.49 -0.17 0.61 2.04 1 2 3 4 5 -2.66 2.66 HS.192729 -0.36 2.06 -0.61 0.08 -0.05 1 2 3 4 5 -2.66 2.66 OR51B4 -0.76 1.54 -1.13 -0.47 0.03 1 2 3 4 -2.67 2.67 LOC642558 -0.65 3.25 0.59 0.31 2.18 1 2 3 4 5 -2.67 2.67 HS.259304 -0.43; 3.24 0.57 0.07 0.09 1 2 3 4 5 -2.67 2.67 OR7D4 1.47 2.36 -0.31 0.19 -0.52 1 2 3 4 5 -2.67 2.67 FU38773 -0.52 4.27 1.59 4.53 0.27 1 2 3 4 5 -2.68 2.68 HS.212764 0.61 2.24 -0.44 0.04 -0.29 1 2 3 4 5 -2.68 2.68 LOC651468 -0.29 2.33 -0.36 0.50 -0.50 1 2 3 4 5 -2.68 2.68 HS.130914 -0.28 2.25 -0.44 -0.68 0.57 1 2 3 4 5 -2.69 2.69 LOC648054 -0.40 2.48 -0.21 0.25 -1.10 1 2 3 4 5 -2.69 2.69 HS.380202 2.10 2.01 -0.68 1.33 0.07 1 2 3 4 5 -2.69 2.69 HS.369401 -0.51 2.48 -0.20 0.12 -0.47 1 2 3 4 5 -2.69 2.69 HS.539612 0.48 1.85 -0.84 -0.51 -0.29 1 2 3 4 5 -2.69 2.69 LOC645033 0.55 2.33 -0.36 -0.41 -0.79 1 2 3 4 5 -2.69 2.69 BIRC8 1.22 2.54 -0.16 -0.19 -0.12 1 2 3 4 5 -2.69 2.69 HS.353127 2.61 4.18 1.48 -1.15 1.32 1 2 3 4 5 -2.70 2.70 TRIM48 2.74 2.54 -0.16 0.23 0.23 1 2 3 4 5 -2.70 2.70 HS.520561 0.91 2.50 -0.20 0.92 -0.85 1 2 3 4 5 -2.70 2.70 HS.563655 -0.28 2.13 -0.57 0.99 0.24 1 2 3 4 5 -2.70 2.70 HS.570428 2.49 3.60 0.90 1.77 -0.32 1 2 3 4 5 -2.70 2.70 HS.544874 -0.34 2.41 -0.30 1.08 0.12 1 2 3 4 5 -2.70 2.70 HS.566877 4.40 2.17 -0.53 1.53 1.08 1 2 3 4 5 -2.71 2.71 Table 3 1 CT45-2 1.73 2.40 -0.31 3.91 1.68 1 2 3 4 5 -2.71 2.71 HS.127366 0.04 2.19 -0.52 -0.91 -0.33 1 2 3 4 5 -2.71 2.71 HS.151274 0.31 1.97 -0.74 -0.84 0.73 1 2 3 4 5 -2.71 2.71 HS.557740 0.63 1.99 -0.72 4.00 -0.12 1 2 3 4 5 -2.71 2.71 HS.566525 3.38 2.65 -0.06 -0.05 -0.63 1 2 3 4 5 -2.71 2.71 UGT1A6 -0.14 1.76 -0.96 -0.93 0.01 1 2 3 4 5 -2.71 2.71 HS.564614 0.22 1.81 -0.91 1.32 3.33 1 2 3 4 5 -2.72 2.72 LOC642587 0.64 2.03 -0.69 -1.25 1.23 1 2 3 4 5 -2.72 2.72 HS.541939 0.65 2.30 -0.41 -0.41 -0.41 1 2 3 4 5 -2.72 2.72 LOC645634 -0.27 2.47 -0.25 0.58 -0.79 1 2 3 4 5 -2.72 2.72 HS.97461 0.51 2.53 -0.20 2.54 -1.02 1 2 3 4 5 -2.72 2.72 HS.62946 -0.37 3.66 0.94 1.76 0.56 1 2 3 4 5 -2.72 2.72 COL21A1 2.52 2.48 -0.24 1.54 1.60 1 2 3 4 5 -2.73 2.73 HS.471148 -0.27 2.57 -0.15 0.60 -0.68 1 2 3 4 5 -2.73 2.73 OR52R1 1.96 2.31 -0.42. 0.87 1.23 1 2 3 4 5 -2.73 2.73 OR6C65 -0.57 3.04 0.31 -0.41 0.28 1 2 3 4 5 -2.73 2.73 LOC647031 -0.99 2.28 -0.45 -0.25 0.45 1 2 3 4 5 -2.73 2.73 HS.583989 -0.14 2.54 -0.19 0.01 -0.01 1 2 3 4 5 -2.73 2.73 LOC643943 4.18 2.17 -0.56 -1.22 -0.25 1 2 3 4 5 -2.73 2.73 HS.564295 1.82 2.44 -0.29 1.29 1.29 1 2 3 4 5 -2.73 2.73 LOC644150 1.47 2.50 -0.24 1.51 2.45 1 2 3 4 5 -2.74 2.74 LOC643083 -0.90 1.20 -1.54 0.59 0.01 1 2 3 4 5 -2.74 2.74 HS.539605 1.76 3.43 0.70 -0.22 0.39 1 2 3 4 5 -2.74 2.74 HS.545267 0.32 2.50 -0.24 -0.38 -0.35 1 2 3 4 5 -2.74 2.74 ANP32D 1.33 2.87 0.13 -1.27 1.44 1 2 3 4 5 -2.75 2.75 LRP2 2.18 1.97 -0.78 0.07 -0.40 1 2 3 4 5 -2.75 2.75 HS.97324 0.43, 2.46 -0.29 1.63 1.76 1 2 3 4 5 -2.75 2.75 HS.544199 0.31 2.14 -0.61 -0.42 1.86 1 2 3 4 5 -2.75 2.75 ARSF 1.51 2.16 -0.59 0.83 2.52 1 2 3 4 5 -2.75 2.75 LOC440059 1.19 2.97 0.22 -0.50 0.48 1 2 3 4 5 -2.75 2.75 C80RF47 1.38 1.96 -0.79 0.73 -0.89 1 2 3 4 5 -2.75 2.75 HS.556696 5.53 2.18 -0.58 0.49 1.41 1 2 3 4 5 -2.75 2.75 C90RF153 1.15 1.45 -1.30 0.44 0.08 1 2 3 4 5 -2.76 2.76 HS.538303 3.52 0.57 -2.18 1.32 0.50 1 2 3 4 5 -2.76 2.76 HS.565391 -2.13 2.49 -0.27 4.06 2.31 1 2 3 4 5 -2.76 2.76 CX0RF1 -0.08 2.42 -0.34 0.34 -0.01 1 2 3 4 5 -2.76 2.76 HS.47878 0.86 2.77 0.01 -0.29 0.07 1 2 3 4 5 -2.76 2.76 OR52H1 2.11 2.35 -0.41 0.47 0.04 1 2 3 4 5 -2.76 2.76 HS.116333 -0.40 2.26 -0.50 0.15 0.27 1 2 3 4 5 -2.76 2.76 HOXD10 -1.35 2.65 -0.12 -1.41 2.30 1 2 3 4 5 -2.76 2.76 HS.554237 -0.09 2.38 -0.38 -0.87 0.20 1 2 3 4 5 -2.76 2.76 SLC6A19 -0.86 3.06 0.30 -0.40 -0.36 1 2 3 4 5 -2.77 2.77 HS.543569 -0.23 2.67 -0.10 0.56 -0.26 1 2 3 4 5 -2.77 2.77 HS.582129 -0.52 1.58 -1.19 3.26 2.10 1 2 3 4 5 -2.77 2.77 LOC649722 -0.12 2.48 -0.29 0.49 0.45 1 2 3 4 5 -2.77 2.77 LOC642316 0.46 3.05 0.28 1.99 -0.12 1 2 3 4 5 -2.77 2.77 IFNB1 0.18 2.79 0.02 -0.52 2.61 1 2 3 4 5 -2.77 2.77 HS.543717 -1.13 0.62 -2.16 -0.20 0.04 1 2 3 4 5 -2.77 2.77 TESSP1 0.13 2.07 -0.71 -0.12 2.14 1 2 3 4 5 -2.78 2.78 Table 3 169 RPl -0.17 3.04 0.26 -0.60 -0.75 1 2 3 4 5 -2.78 2.78 KIAA0319 -0.67 2.41 -0.37 5.11 -0.33 1 2 3 4 5 -2.78 2.78 HS.541431 -0.63 2.37 -0.41 -0.54 -0.33 1 2 3 4 5 -2.78 2.78 BBS5 -0.07 2.34 -0.44 0.26 -0.29 1 2 3 4 5 -2.78 2.78 BEAN 3.93 2.36 -0.43 -0.62 0.48 1 2 3 4 5 -2.78 2.78 HS.565054 1.08 2.46 -0.32 0.59 0.08 1 2 3 4 5 -2.78 2.78 LOC647480 0.94 3.72 0.93 1.05 -0.83 1 2 3 4 5 -2.79 2.79 RAB40A -0.28 2.15 -0.64 0.08 -1.13 1 2 3 4 5 -2.79 2.79 HS.540614 0.46 4.02 1.22 0.02 0.19 1 2 3 4 5 -2.79 2.79 SFRP1 0.94 2.80 0.00 -0.35 -0.75 1 2 3 4 5 -2.80 2.80 HS.379382 -0.83 3.09 0.30 1.24 0.27 1 2 3 4 5 -2.80 2.80 LOC732275 -0.10 2.39 -0.41 2.67 0.93 1 2 3 4 5 -2.80 2.80 FU33706 0.45 3.02 0.22 -0.50 1.07 1 2 3 4 5 -2.80 2.80 HS.538350 -0.06 2.04 -0.76 0.40 1.92 1 2 3 4 5 -2.80 2.80 HS.545389 0.42 2.56 -0.24 0.46 0.06 1 2 3 4 5 -2.81 2.81 OR6K3 0.65 1.86 -0.94 -0.75 -0.01 1 2 3 4 5 -2.81 2.81 HS.566535 -0.75 2.78 -0.03 1.62 -0.69 1 2 3 4 5 -2.81 2.81 SPHKAP 0.30 1.89 -0.92 -0.45 -0.36 1 2 3 4 5 -2.81 2.81 HS.563840 0.33 3.41 0.60 2.09 1.08 1 2 3 4 5 -2.81 2.81 R0B04 -0.74 2.15 -0.67 0.66 -0.01 1 2 3 4 5 -2.82 2.82 HS.126458 -0.34 2.33 -0.49 1.23 -0.65 1 2 3 4 5 -2.82 2.82 HS.574745 1.28 2.82 0.00 0.74 0.58 1 2 3 4 5 -2.82 2.82 HS.582384 -0.50 2.84 0.02 -0.63 0.56 1 2 3 4 5 -2.82 2.82 HS.542036 -0.27 2.09 -0.73 0.56 0.07 1 2 3 4 5 -2.82 2.82 OR4K15 -0.82 2.68 -0.14 1.30 1.20 1 2 3 4 5 -2.82 2.82 HS.122226 1.34 1.36 -1.47 -0.02 3.33 1 2 3 4 5 -2.83 2.83 RAB1C 1.35 3.14 0.31 -0.52 -0.57 1 2 3 4 5 -2.83 2.83 AADACL2 0.64 2.79 -0.04 0.82 -0.36 1 2 3 4 5 -2.83 2.83 ZPBP -0.86 2.64 -0.19 -0.51 1.04 1 2 3 4 5 -2.83 2.83 HS.527155 2.19 1.75 -1.08 3.73 2.71 1 2 3 4 5 -2.83 2.83 HS.558075 -0.52 2.07 -0.76 -0.39 0.70 1 2 3 4 5 -2.83 2.83 HS.537809 -0.30 2.96 0.12 -0.47 -0.51 1 2 3 4 5 -2.83 2.83 HS.566469 1.60 2.62 -0.22 -0.16 0.64 1 2 3 4 5 -2.84 2.84 HS.510367 1.65 2.62 -0.22 0.05 0.09 1 2 3 4 5 -2.84 2.84 SLC18A3 -0.44 1.18 -1.66 -0.25 -0.01 1 2 3 4 5 -2.84 2.84 HS.577138 0.03 2.43 -0.41 0.12 0.25 1 2 3 4 5 -2.84 2.84 TTPA 2.05 1.55 -1.29 0.92 1.72 1 2 3 4 5 -2.84 2.84 LOC653169 1.66 2.73 -0.12 -0.23 1.29 1 2 3 4 5 -2.84 2.84 HS.135735 -0.09 2.33 -0.52 -0.80 0.01 1 2 3 4 5 -2.85 2.85 KDELR3 -0.02 2.69 -0.16 0.77 2.74 1 2 3 4 5 -2.85 2.85 HS.530415 0.44 3.56 0.71 1.05 0.01 1 2 3 4 5 -2.85 2.85 PIP -0.43 2.85 0.00 0.30 0.28 1 2 '3 4 5 -2.85 2.85 SLC38A4 0.74 4.71 1.85 -0.24 -0.30 1 2 3 4 5 -2.86 2.86 HS.156542 1.36 2.61 -0.25 -0.24 -0.41 1 2 3 4 5 -2.86 2.86 LOC646009 2.23 2.96 0.11 1.01 0.91 1 2 3 4 5 -2.86 2.86 HS.559956 3.78 2.18 -0.68 3.99 3.03 1 2 3 4 5 -2.86 2.86 HS.564986 0.76 2.58 -0.28 2.27 1.34 1 2 3 4 5 -2.86 2.86 LOC642867 -0.22 2.22 -0.65 -0.44 1.09 1 2 3 4 5 -2.86 2.86 HS.112662 -1.01 2.61 -0.26 1.13 0.50 1 2 3 4 5 -2.87 2.87 Table 3 170 C80RF49 3.91 1.87 -1.00 0.14 -0.04 1 2 3 4 5 -2.87 2.87 CCDC13 0.66 2.81 -0.07 -0.68 0.33 1 2 3 4 5 -2.87 2.87 OR8D4 0.25 3.39 0.51 -0.67 -0.28 1 2 3 4 5 -2.87 2.87 HS.529889 0.16 2.28 -0.59 0.12 0.29 1 2 3 4 5 -2.87 2.87 HS.196849 0.54 2.04 -0.83 -0.90 -0.61 1 2 3 4 5 -2.88 2.88 HS.350552 0.11 2.57 -0.31 1.22 0.14 1 2 3 4 5 -2.88 2.88 HS.565119 1.82 3.10 0.22 -0.24 -0.52 1 2 3 4 5 -2.88 2.88 LOC647417 0.24 2.98 0.10 0.00 -0.24 1 2 3 4 5 -2.89 2.89 CLGN 1.54 1.14 -1.75 1.10 -0.29 1 2 3 4 5 -2.89 2.89 SNED1 -0.18 2.37 -0.52 0.17 -0.58 1 2 3 4 5 -2.89 2.89 KRT19 -0.79 3.97 1.08 1.66 1.20 1 2 3 4 5 -2.89 2.89 LOC392197 2.72 2.18 -0.71 -0.37 -0.07 1 2 3 4 5 -2.89 2.89 HS.567085 0.57 2.40 -0.49 1.80 0.52 1 2 3 4 5 -2.89 2.89 LOC645004 4.04 4.98 2.09 1.45 0.40 1 2 3 4 5 -2.89 2.89 SCUBE1 -0.51 1.74 -1.16 -1.04 -0.70 1 2 3 4 5 -2.90 2.90 LOC643634 2.19 2.21 -0.69 1.04 -0.05 1 2 3 4 5 -2.90 2.90 0R4M1 1.45 2.69 -0.22 0.73 1.10 1 2 3 4 5 -2.90 2.90 CBWD6 1.02 3.20 0.30 -1.20 2.33 1 2 3 4 5 -2.91 2.91 KRTAP5-6 0.62 2.10 -0.81 3.77 2.39 1 2 3 4 5 -2.91 2.91 LOC389151 1.50 2.07 -0.84 -1.09 1.98 1 2 3 4 5 -2.91 2.91 LOC643993 1.78 3.47 0.56 0.51 -0.41 1 2 3 4 5 -2.91 2.91 LGLL338 4.15 3.03 0.12 3.94 0.02 1 2 3 4 5 -2.91 2.91 HS.545324 1.99 2.46 -0.45 0.38 -1.33 1 2 3 4 5 -2.91 2.91 HS. 12440 -0.06 2.30 -0.62 0.63 -0.51 1 2 3 4 5 -2.92 2.92 TACC2 -0.51 2.93 0.02 1.15 -0.13 1 2 3 4 5 -2.92 2.92 LOC652471 0.49 2.11 -0.82 0.69 2.43 1 2 3 4 5 -2.92 2.92 HS.574301 0.28 1.55 -1.38 -0.03 2.70 1 2 3 4 5 -2.92 2.92 HEATR4 0.61 2.45 -0.47 1.92 0.87 1 2 3 4 5 -2.92 2.92 HS.545141 2.02 2.84 -0.08 -0.45 2.02 1 2 3 4 5 -2.92 2.92 LOC647723 0.22 2.09 -0.83 0.88 -0.69 1 2 3 4 5 -2.93 2.93 HS.525926 -0.15 3.14 0.21 -0.22 -0.06 1 2 3 4 5 -2.93 2.93 HS.390766 -0.15 2.33 -0.60 -0.92 0.74 1 2 3 4 5 -2.93 2.93 HS.560132 0.68 3.27 0.33 3.08 1.44 1 2 3 4 5 -2.94 2.94 LOC648533 0.55 3.36 0.42 2.86 0.92 1 2 3 4 5 -2.94 2.94 HS.554559 0.72 2.24 -0.69 3.40 -0.30 1 2 3 4 5 -2.94 2.94 HS.158672 1.52 2.81 -0.13 -0.19 -0.40 1 2 3 4 5 -2.94 2.94 PRH2 -0.26 2.93 -0.02 1.76 0.57 1 2 3 4 5 -2.95 2.95 HS.545746 -0.37 4.43 1.47 -0.31 -0.12 1 2 3 4 5 -2.95 2.95 LOC390669 0.19 2.42 -0.54 -0.27 2.08 1 2 3 4 5 -2.96 2.96 HS.565494 -0.36 3.32 0.36 1.43 0.73, 1 2 3 4 5 -2.96 2.96 FAM155A -1.26 3.16 0.20 -0.32 0.16 1 2 3 4 5 -2.97 2.97 HS.539859 0.20 2.28 -0.69 -0.38 -1.41 1 2 3 4 5 -2.97 2.97 HS.565097 -0.07 2.21 -0.76 -0.52 -0.59 1 2 3 4 5 -2.97 2.97 .LOC442204 1.45 3.30 0.33 0.71 1.43 1 2 3 4 5 -2.97 2.97 LOC642702 -0.50 2.72 -0.25 0.57 2.52 1 2 3 4 5 -2.97 2.97 SLC3A1 -0.29 2.06 -0.92 0.48 0.84 1 2 3 4 5 -2.97 2.97 LRRC2 -0.15 2.39 -0.59 0.24 -0.14 1 2 3 4 5 -2.98 2.98 HS.560963 3.80 1.78 -1.19 -0.41 3.53 1 2 3 4 5 -2.98 2.98 LRFN5 -0.31 2.32 -0.67 0.09 1.24 1 2 3 4 5 -2.99 2.99 Table 3 171 HS.544493 0.42 2.72 -0.26 0.22 -1.14 1 2 3 4 5 -2.99 2.99 LOC132203 0.35 3.53 0.54 -0.66 0.69 1 2 3 4 5 -2.99 2.99 HS.551221 3.38 2.57 -0.41 2.91 -0.46 1 2 3 4 5 -2.99 2.99 FSCN2 -0.59 2.32 -0.67 0.54 -0.24 1 2 3 4 5 -2.99 2.99 HS.583144 5.09 4.06 1.07 1.07 -0.27 1 2 3 4 5 -2.99 2.99 HS.128108 -0.15 3.00 0.01 -0.37 0.96 1 2 3 4 5 -2.99 2.99 LOC440005 2.10 2.87 -0.13 -2.34 -0.81 1 2 3 4 5 -3.00 3.00 LOC649366 2.75 1.17 -1.83 -1.14 -1.50 1 2 3 4 5 -3.00 3.00 GAB4 1.15 2.95 -0.05 2.58 -0.79 1 2 3 4 5 -3.00 3.00 DEFB126 -0.67 3.18 0.18 -0.09 1.54 1 2 3 4 5 -3.00 3.00 ZIC5 0.28 3.08 0.08 -0.11 -0.02 1 2 3 4 5 -3.00 3.00 CCDC52 -0.41 2.70 -0.31 -0.27 0.24 1 2 3 4 5 -3.01 3.01 HS.578029 1.26. 2.12 -0.89 1.93 4.20 1 2 3 4 5 -3.01 3.01 LOC644578 0.14 3.21 0.19 0.42 -0.03 1 2 3 4 5 -3.01 3.01 HS.574763 1.01 2.52 -0.50 -0.03 0.73 1 2 3 4 5 -3.02 3.02 SYNGR3 0.68 3.56 0.54 3.04 -0.07 1 2 3 4 5 -3.02 3.02 HS.120542 0.24 5.05 2.03 1.13 0.98 1 2 3 4 5 -3.02 3.02 HS.4290 0.79 2.87 -0.16 -0.14 -0.11 1 2 3 4 5 -3.03 3.03 RFPL4B 1.00 3.01 -0.02 0.19 -0.13 1 2 3 4 5 -3.03 3.03 GALNT13 -0.12 2.34 -0.69 -0.33 0.05 1 2 3 4 5 -3.03 3.03 OR5AK2 2.15 4.41 1.37 -0.52 0.18 1 2 3 4 5 -3.03 3.03 HS.149763 1.37 : 3.16 0.13 0.15 0.30 1 2 3 4 5 -3.04 3.04 HS.544592 1.86 3.54 0.50 0.71 0.10 1 2 3 4 5 -3.04 3.04 OR51E1 2.10 3.08 0.04 -0.99 0.24 1 2 3 4 5 -3.04 3.04 HS.542565 1.13 2.33 -0.72 0.32 -0.27 1 2 3 4 5 -3.04 3.04 LOC644402 -0.44 2.81 -0.23 -0.35 0.21 1 2 3 4 5 -3.04 3.04 HS.544249 -0.22 2.60 -0.44 -0.52 -0.13 1 2 3 4 5 -3.04 3.04 FU21062 0.87 j 3.57 0.53 -0.49 1.61 1 2 3 4 5 -3.05 3.05 LOC642564 -1.19 2.45 -0.60 2.65 -0.44 1 2 3 4 5 -3.05 3.05 LOC647983 1.35 2.08 -0.97 0.19 -0.07 1 2 3 4 5 -3.05 3.05 HS.206112 1.12 2.30 -0.75 -0.08 0.19 1 2 3 4 5 -3.05 3.05 HS.278560 -0.12 2.90 -0.16 -0.33 1.49 1 2 3 4 5 -3.06 3.06 HS.98394 0.52 3.59 0.54 0.38 1.54 1 2 3 4 5 -3.06 3.06 HS.541125 0.12 3.24 0.18 0.86 0.63 1 2 3 4 5 -3.06 3.06 OR1F2P 2.42 2.29 -0.77 0.18 0.69 1 2 3 4 5 -3.06 3.06 LOC731000 0.15 ; 2.75 -0.32 0.31 0.60 1 2 3 4 5 -3.06 3.06 HS.539242 1.94 2.69 -0.38 0.22 0.36 1 2 3 4 5 -3.07 3.07 HS.582934 0.59 2.89 -0.18 3.55 0.11 1 2 3 4 5 -3.07 3.07 LOC650673 1.76 2.77 -0.30 0.00 -0.15 1 2 3 4 5 -3.07 3.07 HS.143245 -0.30 2.50 -0.57 0.10 -0.32 1 2 3 4 5 -3.07 3.07 TTTY21 0.76 : 2.99 -0.08 -0.61 -0.36 1 2 3 4 5 -3.07 3.07 HS.544895 5.88 3.36 0.28 -1.37 -0.35 1 2 3 4 5 -3.08 3.08 HS. 104447 1.99 2.33 -0.75 0.25 0.34 1 2 3 4 5 -3.08 3.08 HS.570623 1.66 3.14 0.06 2.79 -0.40 1 2 3 4 5 -3.08 3.08 HS.559102 1.97 2.26 -0.82 1.47 -0.68 1 2 3 4 5 -3.08 3.08 HS.543115 -0.34 2.90 -0.18 -0.13 0.71 1 2 3 4 5 -3.09 3.09 HS.543516 4.17 4.37 1.28 0.07 2.45 1 2 3 4 5 -3.09 3.09 HS.568234 2.47 3.38 0.29 -0.53 -0.66 1 2 3 4 5 -3.09 3.09 USP51 1.20 2.51 -0.58 -0.45 0.02 1 2 3 4 5 -3.09 3.09 Table 3 172 HS.579365 0.41 3.02 -0.08 0.04 -0.08 1 2 3 4 5 -3.09 3.09 HS.509165 -0.30 2.92 -0.18 -0.46 0.42 1 2 3 4 5 -3.10 3.10 ELMOD1 -0.42 .3.27 0.16 0.10 0.34 1 2 3 4 5 -3.10 3.10 SLC5A12 0.52 1.42 -1.68 4.91 1.48 1 2 3 4 5 -3.11 3.11 CXCL12 0.35 3.81 0.70 0.27 -0.09 1 2 3 4 5 -3.11 3.11 KRT6C 0.77 2.36 -0.75 -0.12 -0.91 1 2 3 4 5 -3.11 3.11 LOC169834 -0.17 3.09 -0.02 -0.60 -0.20 1 2 3 4 5 -3.11 3.11 HS.539973 -0.32 5.14 2.03 -0.20 1.06 1 2 3 4 5 -3.11 3.11 LOC286239 -0.45 2.25 -0.87 -1.53 -0.92 1 2 3 4 5 -3.12 3.12 HS.559957 -0.05 3.40 0.28 0.27 -0.93 1 2 3 4 5 -3.12 3.12 HS.563122 -1.40 2.26 -0.86 0.31 0.53 1 2 3 4 5 -3.12 3.12 LOC649179 0.52 3.44 0.32 0.14 0.48 1 2 3 4 5 -3.12 3.12 NANOS2 1.12 3.22 0.09 -0.83 0.18 1 2 3 4 5 -3.12 3.12 LOC649198 1.86 3.28 0.15 -0.90 -0.52 1 2 3 4 5 -3.13 3.13 HS.570821 0.75 3.39 0.27 0.08 1.74 1 2 3 4 5 -3.13 3.13 HS.566019 6.17 2.12 -1.01 1.22 1.88 1 2 3 4 5 -3.13 3.13 LOC648974 0.68 2.82 -0.31 1.56 -0.39 1 2 3 4 5 -3.13 3.13 LOC401358 0.55 3.33 0.20 0.72 0.27 1 2 3 4 5 -3.13 3.13 HS.575820 5.86; 2.57 -0.57 0.02 0.76 1 2 3 4 5 -3.13 3.13 HS.543322 -0.96 2.23 -0.90 -0.18 -0.83 1 2 3 4 5 -3.13 3.13 FRS2 0.10 2.94 -0.20 -0.34 -0.31 1 2 3 4 5 -3.13 3.13 C60RF195 0.85: 4.00 0.86 -0.11 0.79 1 2 3 4 5 -3.13 3.13 HS.399823 0.21 2.88 -0.26 -0.07 0.27 1 2 3 4 5 -3.14 3.14 LOC340602 0.71 3.30 0.16 -0.49 -0.12 1 2 3 4 5 -3.14 3.14 LOC649414 0.45 2.35 -0.80 -0.18 1.50 1 2 3 4 5 -3.15 3.15 HS.443361 6.11 2.32 -0.83 -2.32 -2.12 1 2 3 4 5 -3.15 3.15 HS.548349 0.47^ 3.45 0.30 0.92 -0.64 1 2 3 4 5 -3.15 3.15 ACE 0.39' 3.12 -0.04 -0.63 -0.20 1 2 3 4 5 -3.15 3.15 HS.566356 1.37! 3.57 0.42 0.36 0.33 1 2 3 4 5 -3.15 3.15 MTNR1A 2.20 2.45 -0.70 1.92 -1.06 1 2 3 4 5 -3.15 3.15 HS.571140 0.00 2.54 -0.61 -0.33 -0.30 1 2 3 4 5 -3.16 3.16 OR2T35 -0.68 2.39 -0.77 -0.81 0.01 1 2 3 4 5 -3.16 3.16 LOC642563 0.29 2.80 -0.36 -0.25 1.05 1 2 3 4 5 -3.16 3.16 HS.541575 0.06 2.80 -0.36 0.78 -0.78 1 2 3 4 5 -3.16 3.16 LOC652246 1.25 3.17 0.01 -0.66 -0.55 1 2 3 4 5 -3.16 3.16 LOC642904 0.82 3.09 -0.07 -0.40 1.15 1 2 3 4 5 -3.16 3.16 GLULD1 -0.59 3.31 0.14 0.17 -0.16 1 2 3 4 5 -3.17 3.17 LOC643808 -0.70 1.87 -1.30 1.65 -0.50 1 2 3 4 5 -3.17 3.17 HS.134650 -0.78 3.74 0.57 -0.60 -0.56 1 2 3 4 5 -3.17 3.17 CNTD1 1.78' 3.35 0.18 -0.91 -0.56 1 2 3 4 5 -3.17 3.17 LOC441759 0.76 2.35 -0.82 3.22 1.11 1 2 3 4 5 -3.17 3.17 LOC388259 1.82 2.97 -0.21 -0.87 -0.27 1 2 3 4 5 -3.17 3.17 HS.547693 -0.20 2.80 -0.37 0.96 0.27 1 2 3 4 5 -3.17 3.17 HS.539798 0.43 2.67 -0.50 -0.82 -0.35 1 2 3 4 5 -3.17 3.17 OR2J3 -0.84 2.58 -0.59 1.00 -0.32 1 2 3 4 5 -3.17 3.17 HS.297628 0.54 2.66 -0.52 -0.93 0.46 1 2 3 4 5 -3.17 3.17 HS.545083 -0.59 3.09 -0.09 0.41 0.12 1 2 3 4 5 -3.18 3.18 MPN2 0.73 2.12 -1.06 1.39 -0.52 1 2 3 4 5 -3.18 3.18 HS.576001 0.46 2.76 -0.41 0.56 -0.60 1 2 3 4 5 -3.18 3.18 Table 3 173 LOC652860 -0.88 2.32 -0.86 0.01 2.87 1 2 3 4 5 -3.18 3.18 HS.562841 0.20 3.17 -0.01 0.03 0.03 1 2 3 4 5 -3.18 3.18 HS.434311 0.74 3.81 0.63 -1.55 0.70 1 2 3 4 5 -3.19 3.19 DKFZP586H2123 0.18 1.46 -1.73 -0.96 -1.23 1 2 3 4 5 -3.19 3.19 HS.564653 -0.25 3.15 -0.05 0.00 0.13 1 2 3 4 5 -3.19 3.19 HS.580525 0.01 2.41 -0.79 -0.27 -1.68 1 2 3 4 5 -3.20 3.20 LOC644251 1.68 2.87 -0.33 1.07 0.02 1 2 3 4 5 -3.20 3.20 HS.427939 0.08 3.15 -0.05 0.71 0.51 1 2 3 4 5 -3.20 3.20 HRNR 0.04 2.77 -0.43 -0.10 0.52 1 2 3 4 5 -3.20 3.20 HS.543114 0.17 2.86 -0.34 0.03 0.55 1 2 3 4 5 -3.21 3.21 LOC642196 0.88 2.00 -1.21 3.31 -0.07 1 2 3 4 5 -3.21 3.21 HS.542988 1.65 2.84 -0.38 -0.23 2.93 1 2 3 4 5 -3.21 3.21 HS.577164 -0.86 3.87 0.66 -0.41 1.40 1 2 3 4 5 -3.21 3.21 HS.571014 0.38 4.26 1.04 3.51 -0.33 1 2 3 4 5 -3.22 3.22 HS.365088 5.60 2.66 -0.56 0.42 0.04 1 2 3 4 5 -3.22 3.22 HS.436248 0.15 3.15 -0.07 0.65 -0.24 1 2 3 4 5 -3.22 3.22 LOC643082 0.48 5.01 1.79 0.70 1.50 1 2 3 4 5 -3.22 3.22 GDF2 -0.05 2.35 -0.88 -1.04 -0.95 1 2 3 4 5 -3.22 3.22 HS.542469 -0.54 3.36 0.13 -0.03 -0.13 1 2 3 4 5 -3.23 3.23 HS.437730 -1.22 3.22 0.00 -0.86 -0.84 1 2 3 4 5 -3.23 3.23 LOC652570 1.22 2.93 -0.30 2.41 2.62 1 2 3 4 5 -3.23 3.23 HS.447655 0.84 3.19 -0.04 -0.16 -0.35 1 2 3 4 5 -3.23 3.23 HS.563549 0.68 2.09 -1.15 2.70 -0.11 1 2 3 4 5 -3.23 3.23 HS.255067 1.44 1.99 -1.25 1.99 -0.32 1 2 3 4 5 -3.24 3.24 RBM24 0.14 4.21 0.98 2.80 0.37 1 2 3 4 5 -3.24 3.24 HS.513653 -0.58 2.56 -0.68 0.47 -0.18 1 2 3 4 5 -3.24 3.24 CLCA3 1.21 4.09 0.84 3.51 -0.22 1 2 3 4 5 -3.24 3.24 HS.571535 0.61 3.75 0.51 1.12 0.65 1 2 3 4 5 -3.24 3.24 HS.440408 0.03 2.19 -1.06 0.39 -0.06 1 2 3 4 5 ; -3.24 3.24 LOC646119 1.14 1.81 -1.44 -1.84 0.52 1 2 3 4 5 -3.25 3.25 FU35848 1.24 3.74 0.48 -0.40 -0.45 1 2 3 4 5 -3.26 3.26 HS.542190 1.45 2.37 -0.89 -1.29 -0.13 1 2 3 4 5 -3.26 3.26 LOC729487 -0.29 2.98 -0.28 0.00 0.08 1 2 3 4 5 -3.26 3.26 DEFB127 2.17 2.54 -0.72 -1.13 -0.66 1 2 3 4 5 -3.26 3.26 CHST5 -0.57 3.17 -0.09 0.00 -0.72 1 2 3 4 5 -3.26 3.26 HS.193331 3.31 2.36 -0.90 2.23 -0.79 1 2 3 4 5 -3.26 3.26 HS.278111 0.08 1.85 -1.41 -0.29 0.62 1 2 3 4 5 -3.26 3.26 HS.441066 -1.33 3.71 0.44 0.99 -0.54 1 2 3 4 5 -3.27 3.27 KCNS3 0.37 3.43 0.15 -0.87 2.94 1 2 3 4 5 -3.27 3.27 LOC643767 1.47 2.94 -0.33 1.18 -0.60 1 2 3 4 5 -3.27 3.27 LOC643296 0.63 3.34 0.07 0.27 1.18 1 2 3 4 5 -3.27 3.27 LOC652437 0.42 5.24 1.97 0.20 -0.40 1 2 3 4 5 -3.27 3.27 KRT38 0.39 1.61 -1.67 -1.48 1.40 1 2 3 4 5 -3.28 3.28 HS.544588 0.10 3.73 0.44 0.47 -0.21 1 2 3 4 5 -3.29 3.29 HS.439498 -0.61 2.82 -0.47 0.44 -0.13 1 2 3 4 5 -3.29 3.29 LOC255187 -0.81 2.85 -0.44 -0.67 -0.45 1 2 3 4 5 -3.29 3.29 LOC100101121 0.12 3.02 -0.27 -0.42 1.34 1 2 3 4 5 -3.29 3.29 HS.495641 -0.80 3.23 -0.07 0.54 -0.40 1 2 3 4 5 -3.29 3.29 LOC644444 2.30 3.04 -0.26 -0.85 0.45 1 2 3 4 5 -3.30 3.30 Table 3 174 HS.568544 0.14 2.66 -0.63 -0.28 1.55 1 2 3 4 5 -3.30 3.30 HS.539250 -0.68 3.30 -0.01 -0.56 0.20 1 2 3 4 5 -3.31 3.31 HS.460921 1.99 2.52 -0.79 0.62 -1.21 1 2 3 4 5 -3.31 3.31 INCA1 0.17 2.49 -0.82 -0.72 0.22 1 2 3 4 5 -3.31 3.31 POU4F2 -0.80 3.43 0.11 -0.32 0.52 1 2 3 4 5 -3.31 3.31 LOC651730 2.31 2.42 -0.89 -1.24 -0.75 1 2 3 4 5 -3.31 3.31 FCRL1 0.74 3.69 0.38 1.13 0.41 1 2 3 4 5 -3.32 3.32 FA 83 B 1.19 3.08 -0.24 -1.42 -0.20 1 2 3 4 5 -3.32 3.32 LOC644379 0.74 4.32 0.99 1.29 4.14 1 2 3 4 5 -3.32 3.32 HS.578401 0.01 2.93 -0.40 -0.12 0.01 1 2 3 4 5 -3.33 3.33 HS.480679 0.72 2.57 -0.76 -1.60 0.17 1 2 3 4 5 -3.33 3.33 PLCD3 -0.31 2.76 -0.57 1.47 0.29 1 2 3 4 5 -3.33 3.33 NANOG -0.26 2.25 -1.09 -0.11 -1.26 1 2 3 4 5 -3.34 3.34 LOC645811 3.23 3.53 0.19 -0.35 -1.04 1 2 3 4 5 -3.34 3.34 LOC646654 -0.44 2.79 -0.56 0.77 -1.14 1 2 3 4 5 -3.34 3.34 LOC731641 0.42 2.89 -0.46 -0.17 -0.28 1 2 3 4 5 -3.34 3.34 HS.572114 1.18 2.88 -0.46 1.73 0.95 1 2 3 4 5 -3.35 3.35 LOC644429 -0.53 3.33 -0.02 -0.39 0.33 1 2 3 4 5 -3.35 3.35 HS.150846 -0.19 3.62 0.27 1.36 1.16 1 2 3 4 5 -3.35 3.35 HS.563551 0.72 3.03 -0.32 0.56 0.68 1 2 3 4 5 -3.35 3.35 HS.566516 -0.42^ 3.09 -0.27 0.02 -0.31 1 2 3 4 5 -3.36 3.36 LOC652579 0.80 2.28 -1.08 2.45 -0.14 1 2 3 4 5 -3.36 3.36 HS.545766 2.04! 3.24 -0.12 0.12 -0.28 1 2 3 4 5 -3.36 3.36 CRABP1 1.29 2.91 -0.45 1.92 0.74 1 2 3 4 5 -3.36 3.36 FU40244 5.05: 4.52 1.16 0.37 3.92 1 2 3 4 5 -3.37 3.37 LOC283202 -0.25 3.54 0.16 1.07 1.53 1 2 3 4 5 -3.37 3.37 HS.545640 -0.33 3.00 -0.37 -0.33 -0.61 1 2 3 4 5 -3.37 3.37 HS.553350 -0.45 3.11 -0.28 0.63 -0.11 1 2 3 4 5 -3.38 3.38 LOC653759 1.01 2.53 -0.86 -0.41 0.15 1 2 3 4 5 -3.38 3.38 HS.579599 1.69 3.94 0.55 1.14 2.44 1 2 3 4 5 -3.39 3.39 HS.21600 -0.53 2.97 -0.42 -0.11 -0.56 1 2 3 4 5 -3.39 3.39 FU35258 -0.28 3.10 -0.29 0.28 1.89 1 2 3 4 5 -3.39 3.39 LOC645139 4.19 2.39 -1.01 -0.41 -0.41 1 2 3 4 5 -3.40 3.40 HS.291166 -0.59 2.77 -0.63 -0.28 -0.70 1 2 3 4 5 -3.40 3.40 HS.208719 -1.10, 1.83 -1.57 -0.96 1.09 1 2 3 4 5 -3.40 3.40 LOC646280 2.67 2.83 -0.58 0.76 -0.52 1 2 3 4 5 -3.41 3.41 HS.149354 0.27 2.15 -1.26 -0.48 -1.03 1 2 3 4 5 -3.41 3.41 HS.565716 1.30 2.48 -0.92 1.55 -0.18 1 2 3 4 5 -3.41 3.41 HS.559777 0.81 2.60 -0.82 -0.84 6.02 1 2 3 4 5 -3.42 3.42 LOC645418 -0.65 2.87 -0.55 0.00 2.77 1 2 3 4 5 -3.42 3.42 HS.123398 -0.26 3.41 -0.01 -1.11 0.94 1 2 3 4 5 -3.42 3.42 LOC651872 -0.33 3.35 -0.08 -0.21 0.31 1 2 3 4 5 -3.43 3.43 HS.148462 0.27 3.68 0.25 1.43 0.63 1 2 3 4 5 -3.43 3.43 HS.578021 2.23 2.98 -0.46 1.03 0.15 1 2 3 4 5 -3.43 3.43 HS.547653 -0.04 4.77 1.34 1.56 0.92 1 2 3 4 5 -3.43 3.43 SLC25A2 -0.26 3.02 -0.42 1.42 0.57 1 2 3 4 5 -3.43 3.43 HS.553479 0.68 2.69 -0.74 -0.56 0.41 1 2 3 4 5 -3.44 3.44 HS.170701 0.89 3.43 -0.01 0.11 0.69 1 2 3 4 5 -3.44 3.44 HS.566569 0.48 3.56 0.12 -0.02 3.11 1 2 3 4 5 -3.44 3.44 Table 3 175 HS.511796 -0.19 2.01 -1.43 1.26 0.41 1 2 3 4 5 -3.44 3.44 CCDC60 0.53 3.32 -0.13 0.27 -0.17 1 2 3 4 5 -3.46 3.46 FU41821 1.52 3.52 0.07 -0.02 2.11 1 2 3 4 5 -3.46 3.46 HS.555525 1.14 3.03 -0.43 1.89 0.88 1 2 3 4 5 -3.46 3.46 HS.528312 -0.09 3.20 -0.27 0.20 -0.02 1 2 3 4 5 -3.47 3.47 LOC650841 -0.18 3.03 -0.44 0.43 1.37 1 2 3 4 5 -3.48 3.48 HS.554550 -0.17 3.25 -0.23 -0.36 0.75 1 2 3 4 5 -3.48 3.48 PSG7 -1.17 2.31 -1.17 -0.99 -0.19 1 2 3 4 5 -3.48 3.48 HS.98173 -0.41 2.52 -0.96 0.25 0.88 1 2 3 4 5 -3.48 3.48 LOC645908 -0.60 3.63 0.14 -1.22 0.78 1 2 3 4 5 -3.49 3.49 CLDN11 -0.54 3.27 -0.23 0.05 0.86 1 2 3 4 5 -3.49 3.49 LOC643948 -0.20 2.97 -0.53 -0.10 -0.47 1 2 3 4 5 -3.50 3.50 FXYD3 0.34 2.68 -0.82 2.75 1.01 1 2 3 4 5 -3.50 3.50 DEFB103A 1.73 3.80 0.30 -0.18 -0.35 1 2 3 4 5 -3.50 3.50 HS.552127 0.98 2.08 -1.43 2.09 1.02 1 2 3 4 5 -3.51 3.51 LOC387693 1.58 2.82 -0.69 -0.74 0.53 1 2 3 4 5 -3.51 3.51 HS.580927 -0.34 2.34 -1.17 -0.77 2.28 1 2 3 4 5 -3.52 3.52 EBF2 1.45 4.14 0.62 -0.17 0.61 1 2 3 4 5 -3.52 3.52 EDN2 1.46 2.97 -0.55 2.44 0.51 1 2 3 4 5 -3.52 3.52 GSTM5 -0.24 3.19 -0.33 -0.39 -0.33 1 2 3 4 5 -3.52 3.52 HS.541008 0.86 2.07 -1.46 -0.10 -0.95 1 2 3 4 5 -3.53 3.53 HS.188369 -0.36 3.22 -0.32 -0.31 1.11 1 2 3 4 5 -3.53 3.53 HS.538112 0.77 4.29 0.76 0.11 -0.63 1 2 3 4 5 -3.53 3.53 ATP10B 0.82 3.27 -0.26 -0.04 1.08 1 2 3 4 5 -3.53 3.53 HS.580597 2.01 3.42 -0.12 -0.28 0.20 1 2 3 4 5 -3.54 3.54 HS.567013 -0.03 2.80 -0.74 3.26 0.74 1 2 3 4 5 -3.54 3.54 HS.545495 0.55 3.55 0.00 0.54 0.38 1 2 3 4 5 -3.55 3.55 TPSG1 1.77 2.71 -0.84 -0.58 1.37 1 2 3 4 5 -3.55 3.55 HS.104807 2.19 2.38 -1.17 -0.73 -0.27 1 2 3 4 5 -3.55 3.55 HS.579710 2.86 4.72 1.17 1.25 0.12 1 2 3 4 5 -3.55 3.55 HS.310020 2.16 2.92 -0.64 0.77 1.41 1 2 3 4 5 -3.55 3.55 CRB2 -0.17 3.78 0.22 -0.25 -0.32 1 2 3 4 5 -3.56 3.56 HS.559811 1.83 2.63 -0.93 -0.57 -0.37 1 2 3 4 5 -3.56 3.56 FUT2 0.64 2.62 -0.93 -0.84 0.61 1 2 3 4 5 -3.56 3.56 HS.552680 -1.14 2.64 -0.92 -1.29 -0.18 1 2 3 4 5 -3.56 3.56 AKAP6 -0.69 2.52 -1.04 0.26 3.76 1 2 3 4 5 -3.56 3.56 HS.4892 2.09 3.72 0.16 0.48 0.66 1 2 3 4 5 -3.56 3.56 HS.248172 -0.80 4.02 0.46 0.81 -0.31 1 2 3 4 5 -3.56 3.56 HS.544444 1.46: 3.09 -0.48 -0.54 0.42 1 2 3 4 5 -3.57 3.57 LOC375010 1.65 2.52 -1.05 5.43 0.71 1 2 3 4 5 -3.57 3.57 LOC646174 -0.25 3.24 -0.33 0.98 0.62 1 2 3 4 5 -3.57 3.57 LOC284009 -0.83 2.96 -0.62 -1.23 -0.83 1 2 3 4 5 -3.57 3.57 RAG2 1.27 3.03 -0.55 1.91 2.90 1 2 3 4 5 -3.58 3.58 LOC100101266 1.77 3.26 -0.33 -0.14 -0.16 1 2 3 4 5 -3.58 3.58 HS.572057 -0.10 2.88 -0.70 -0.30 0.10 1 2 3 4 5 -3.59 3.59 HS.565141 -0.13 3.35 -0.24 0.47 3.15 1 2 3 4 5 -3.59 3.59 HS.575019 1.19 3.23 -0.36 1.08 0.89 1 2 3 4 5 -3.59 3.59 HS.212055 -0.15 3.07 -0.53 0.00 -0.40 1 2 3 4 5 -3.59 3.59 HS.283647 0.52 3.27 -0.33 -0.59 0.41 1 2 3 4 5 -3.60 3.60 Table 3 176 SYT6 -0.96 2.93 -0.68 0.84 0.26 1 2 3 4 5 -3.61 3.61 HS.544911 -0.02 3.23 -0.38 0.57 -1.14 1 2 3 4 5 -3.61 3.61 HS.519819 1.59 3.34 -0.29 -0.60 0.13 1 2 3 4 5 -3.62 3.62 C40RF17 0.20 4.20 0.57 3.34 -0.79 1 2 3 4 5 -3.63 3.63 HS.565399 -0.18 3.07 -0.56 0.02 0.74 1 2 3 4 5 -3.63 3.63 HS.565462 -0.37 3.02 -0.60 -0.37 -0.75 1 2 3 4 5 -3.63 3.63 HS.436107 5.92 3.20 -0.43 -0.23 -0.33 1 2 3 4 5 -3.63 3.63 HS.445219 -1.24 2.59 -1.04 2.59 -1.42 1 2 3 4 5 -3.63 3.63 HS.148271 0.49 2.93 -0.71 -0.14 -0.23 1 2 3 4 5 -3.63 3.63 LOC644819 3.35 4.23 0.59 0.94 0.83 1 2 3 4 5 -3.64 3.64 HS.162031 0.95 3.87 0.23 -0.38 -0.19 1 2 3 4 5 -3.64 3.64 HS.544351 0.03 4.08 0.43 0.82 0.95 1 2 3 4 5 -3.65 3.65 HS.132414 1.32 2.94 -0.73 5.09 -0.30 1 2 3 4 5 -3.66 3.66 HS.544062 1.92 3.06 -0.61 2.12 1.59 1 2 3 4 5 -3.67 3.67 HS.578532 1.29 3.52 -0.16 -0.13 -0.74 1 2 3 4 5 -3.67 3.67 HS.565345 -1.38 2.61 -1.08 -1.14 -0.49 1 2 3 4 5 -3.68 3.68 HS.428111 2.13 3.15 -0.53 0.09 -0.24 1 2 3 4 5 -3.68 3.68 HS.543788 -0.39 2.72 -0.96 0.90 0.59 1 2 3 4 5 -3.68 3.68 HS.547225 1.35: 2.83 -0.86 -0.35 -0.44 1 2 3 4 5 -3.69 3.69 SERPINB4 1.82 2.65 -1.04 0.41 1.48 1 2 3 4 5 -3.69 3.69 C180RF2 -0.14; 3.67 -0.02 0.19 1.46 1 2 3 4 5 -3.69 3.69 AMTN 1.70 4.05 0.36 2.86 0.20 1 2 3 4 5 -3.70 3.70 LOC641835 0.40 2.96 -0.74 2.66 2.65 1 2 3 4 5 -3.70 3.70 LOC654056 2.51; 3.98 0.28 1.84 0.41 1 2 3 4 5 -3.70 3.70 HS.543820 -0.38 4.01 0.31 -0.06 -0.38 1 2 3 4 5 -3.70 3.70 HS.543924 -0.19 3.64 -0.08 -0.27 -0.17 1 2 3 4 5 -3.72 3.72 HS.104733 -0.42 3.46 -0.26 -0.37 -0.16 1 2 3 4 5 -3.72 3.72 HS.543571 -0.42: 3.28 -0.45 -0.35 0.19 1 2 3 4 5 -3.73 3.73 KRTAP4-11 0.86 3.25 -0.48 -0.86 -0.40 1 2 3 4 5 -3.73 3.73 KRT14 0.42 3.32 -0.43 -0.18 -0.62 1 2 3 4 5 : -3.75 3.75 HS.545191 0.92; 3.81 0.07 1.56 -0.34 1 2 3 4 5 -3.75 3.75 HS.565491 -0.16 3.57 -0.18 -0.04 0.12 1 2 3 4 5 -3.75 3.75 HS.561034 0.77: 3.32 -0.43 0.06 0.44 1 2 3 4 5 -3.75 3.75 TRHDE 0.35 2.68 -1.07 -1.03 0.39 1 2 3 4 5 -3.75 3.75 HS.564642 -0.67 3.18 -0.57 0.17 -0.47 1 2 3 4 5 -3.75 3.75 LOC642918 1.90 3.26 -0.49 -0.21 0.04 1 2 3 4 5 -3.75 3.75 PLAT 0.00 . 2.81 -0.96 2.85 0.37 1 2 3 4 5 -3.77 3.77 LOC642830 -0.22 2.42 -1.36 0.56 0.66 1 2 3 4 5 -3.77 3.77 LRRC44 0.06 3.47 -0.31 -0.08 -0.42 1 2 3 4 5 -3.78 3.78 HS.570385 -0.78 3.48 -0.30 0.71 -0.71 1 2 3 4 5 -3.78 3.78 MYL3 -0.05 4.23 0.45 0.91 1.96 1 2 3 4 5 -3.78 3.78 HS.545846 0.48 3.07 -0.73 -0.68 -0.76 1 2 3 4 5 -3.80 3.80 LOC643749 -1.11 3.51 -0.29 2.95 -0.02 1 2 3 4 5 -3.80 3.80 SPINK8 4.82 4.72 0.92 5.04 1.50 1 2 3 4 5 -3.80 3.80 LOC651562 -0.87 5.10 1.29 2.40 -0.13 1 2 3 4 5 -3.80 3.80 WFDCIOA 2.50 2.84 -0.96 -0.02 0.52 1 2 3 4 5 -3.80 3.80 HS.368423 -0.25 3.61 -0.20 -0.10 0.08 1 2 3 4 5 -3.81 3.81 HS.564548 2.61 3.14 -0.67 -0.39 -0.66 1 2 3 4 5 -3.81 3.81 HMX3 1.41 4.26 0.44 -0.11 -0.64 1 2 3 4 5 -3.82 3.82 Table 3 177

OR2T5 0.18 5.64 1.81 2.39 -1.52 1 2 3 4 5 -3.83 3.83 LOC728951 0.03 4.04 0.21 0.15 -0.21 1 2 3 4 5 -3.83 3.83 ARG1 1.84 3.84 0.02 -0.28 0.04 1 2 3 4 5 -3.83 3.83 LOC642104 2.65 3.34 -0.49 -1.12 4.05 1 2 3 4 -3.83 3.83 HS.181536 2.72 3.49 -0.35 -0.73 1.41 1 2 3 4 5 -3.84 3.84 HS.576488 -0.46 3.85 0.01 0.30 0.14 1 2 3 4 5 -3.84 3.84 HS.207565 3.80 3.64 -0.19 0.77 1.13 1 2 3 4 5 -3.84 3.84 HS.517922 0.70 3.21 -0.64 0.61 2.15 1 2 3 4 5 -3.84 3.84 HS.558003 5.36 2.78 -1.06 0.25 0.00 1 2 3 4 5 -3.84 3.84 NPHP1 0.69 3.10 -0.74 0.49 2.51 1 2 3 4 5 -3.84 3.84 LOC120376 -0.77 3.74 -0.10 -0.08 -0.32 1 2 3 4 5 -3.84 3.84 GPR37 2.44 2.92 -0.93 0.19 -0.18 1 2 3 4 5 -3.85 3.85 LOC648521 3.87 4.99 1.13 -0.25 1.24 1 2 3 4 5 -3.86 3.86 TMEM74 0.93 2.22 -1.64 3.01 2.38 1 2 3 4 5 -3.86 3.86 HS.563649 -0.40 4.73 0.86 1.25 0.03 1 2 3 4 5 -3.87 3.87 HS.540137 0.69 5.66 1.80 1.08 -1.22 1 2 3 4 5 -3.87 3.87 HS.540351 1.46 4.57 0.68 0.16 0.47 1 2 3 4 5 -3.89 3.89 HS.200774 1.73 4.53 0.62 4.10 -0.07 1 2 3 4 5 -3.91 3.91 HS.147700 -0.45 4.00 0.09 -0.69 0.62 1 2 3 4 5 -3.92 3.92 LOC642338 0.39 3.25 -0.67 1.33 -0.12 1 2 3 4 5 -3.92 3.92 KIAA0284 0.89 3.48 -0.44 1.04 1.21 1 2 3 4 5 -3.92 3.92 HS.545588 1.19 3.41 -0.51 -0.69 5.08 1 2 3 4 5 -3.92 3.92 LOC646342 -0.58 4.20 0.27 -1.55 1.68 1 2 3 4 5 -3.93 3.93 HS.195726 1.48 3.88 -0.05 -0.40 -0.45 1 2 3 4 5 -3.93 3.93 HS.195349 0.98 2.71 -1.23 -0.82 0.87 1 2 3 4 5 -3.93 3.93 TAS2R1 -0.17 3.34 -0.60 1.63 0.38 1 2 3 4 5 -3.94 3.94 SLITRK1 0.25 3.19 -0.75 -0.24 0.06 1 2 3 4 -3.94 3.94 HS.171984 -0.82 3.46 -0.48 -0.80 -0.74 1 2 3 4 5 -3.94 3.94 HS.256740 3.71 4.29 0.34 0.48 -1.51 1 2 3 4 -3.95 3.95 HS.134153 -0.63 3.13 -0.82 -0.01 0.85 1 2 3 4 5 -3.95 3.95 HS. 144809 -0.35 3.11 -0.84 0.27 0.13 1 2 3 4 5 -3.96 3.96 PRAMEF6 -0.59 3.67 -0.29 2.21 0.39 1 2 3 4 5 -3.96 3.96 HS.542617 -0.19 3.88 -0.08 4.56 -0.72 1 2 3 4 5 -3.96 3.96 HS.234478 0.44 2.71 -1.25 1.32 0.19 1 2 3 4 5 -3.96 3.96 HS.127874 -0.37 3.75 -0.23 2.16 -0.21 1 2 3 4 5 -3.97 3.97 HS.543330 2.39 4.95 0.97 -0.29 0.79 1 2 3 4 5 -3.98 3.98 PCDHGA12 0.19, 3.48 -0.50 1.14 -0.29 1 2 3 4 5 -3.98 3.98 HS.559588 1.58 3.37 -0.61 -0.53 -0.51 1 2 3 4 5 -3.98 3.98 HS.564500 2.86i 3.01 -0.99 -0.57 3.72 1 2 3 4 5 -4.00 4.00 LOC642566 1.22 4.45 0.44 -0.28 -0.24 1 2 3 4 5 -4.01 4.01 LOC283585 -0.23 3.62 -0.39 0.56 0.39 1 2 3 4 5 -4.01 4.01 CDY1 -0.84 4.06 0.04 0.32 1.19 1 2 3 4 5 -4.01 4.01 HS.436205 -0.49 4.13 0.11 0.54 1.66 1 2 3 4 5 -4.02 4.02 GPR152 -0.98 4.18 0.15 0.31 -1.30 1 2 3 4 5 -4.03 4.03 LOC653905 -0.11 3.80 -0.24 0.01 0.66 1 2 3 4 5 -4.04 4.04 LOC441171 0.95 3.45 -0.60 -0.69 0.48 1 2 3 4 5 -4.04 4.04 SLITRK3 0.20 4.22 0.15 0.73 1.32 1 2 3 4 5 -4.07 4.07 HS.150471 -0.37 3.19 -0.88 0.91 3.76 1 2 3 4 5 -4.07 4.07 FUT3 1.99 3.53 -0.54 0.57 0.79 1 2 3 4 5 -4.07 4.07 Table 3 178 ZNF765 -2.10 2.86 -1.22 -0.21 0.15 1 2 3 4 5 -4.07 4.07 DKFZP686C2281 1.67 3.05 -1.03 -0.67 0.67 1 2 3 4 5 -4.08 4.08 HS.545585 1.72 3.18 -0.91 1.38 2.09 1 2 3 4 5 -4.09 4.09 HS.563046 -0.75 5.76 1.66 2.76 -0.15 1 2 3 4 5 -4.09 4.09 HS.541810 2.61 3.10 -1.00 1.19 2.08 1 2 3 4 5 -4.10 4.10 HS.578089 -0.08 3.93 -0.17 0.06 0.07 1 2 3 4 5 -4.10 4.10 LOC648745 -0.36 3.44 -0.68 -0.03 -0.32 1 2 3 4 5 -4.12 4.12 HS.529318 -0.76 4.24 0.11 0.50 1.88 1 2 3 4 5 -4.12 4.12 HS.545992 2.31 4.02 -0.10 0.03 -0.52 1 2 3 4 5 -4.12 4.12 HS.541093 0.01 3.94 -0.19 0.62 -0.33 1 2 3 4 5 -4.13 4.13 HS.121392 1.66 4.11 -0.03 0.82 0.67 1 2 3 4 5 -4.14 4.14 HS.580142 -0.09 4.49 0.35 -0.56 -0.61 1 2 3 4 5 -4.14 4.14 LOC649442 0.18 2.70 -1.45 1.15 2.63 1 2 3 4 5 -4.15 4.15 HS.149022 -0.05 3.91 -0.24 1.06 1.65 1 2 3 4 5 -4.15 4.15 HS.185515 -0.52 4.39 0.23 1.93 -0.66 1 2 3 4 5 -4.15 4.15 HS.539345 0.90 4.58 0.43 2.69 -0.04 1 2 3 4 5 -4.16 4.16 LOC641311 1.23 4.61 0.44 -0.36 1.22 1 2 3 4 5 -4.17 4.17 TBX5 1.66 2.81 -1.36 -0.74 0.04 1 2 3 4 5 -4.17 4.17 MSMB -0.52 3.43 -0.75 -0.53 -0.23 1 2 3 4 5 -4.19 4.19 LOC653866 1.13 2.87 -1.32 -0.54 0.72 1 2 3 4 5 -4.19 4.19 HS.376609 1.08 6.26 2.05 2.25 -1.78 1 2 3 4 5 -4.20 4.20 HS.214174 0.07 4.17 -0.04 -0.16 0.06 1 2 3 4 5 -4.21 4.21 HS.567169 -0.12 5.36 1.14 -0.44 0.26 1 2 3 4 5 -4.23 4.23 C60RF185 0.08 4.74 0.50 8.38 3.74 1 2 3 4 5 -4.24 4.24 HS.580460 -0.57 4.57 0.33 0.86 0.83 1 2 3 4 5 -4.24 4.24 HS.581279 1.54 3.30 -0.95 0.30 0.18 1 2 3 4 5 -4.25 4.25 LOC389396 -0.37 3.80 -0.45 0.43 0.96 1 2 3 4 5 -4.25 4.25 HS.559682 1.14 5.23 0.98 -0.47 1.98 1 2 3 4 5 -4.25 4.25 HS.580206 1.41 4.47 0.21 1.92 4.22 1 2 3 4 5 -4.26 4.26 HS.561702 0.19 4.96 0.67 -0.37 0.77 1 2 3 4 5 -4.29 4.29 HS.529582 0.82 2.92 -1.37 0.27 -0.20 1 2 3 4 5 -4.29 4.29 LOC643660 -0.18 3.61 -0.68 0.29 -0.16 1 2 3 4 5 -4.30 4.30 PAK3 -0.26 4.42 0.11 1.26 0.66 1 2 3 4 5 -4.30 4.30 HS.209445 0.23 4.03 -0.28 0.94 0.51 1 2 3 4 5 -4.32 4.32 PIK3C2G 0.46 3.64 -0.69 5.27 1.28 1 2 3 4 5 -4.33 4.33 HS.201822 -0.32 3.89 -0.45 -0.65 0.25 1 2 3 4 5 -4.34 4.34 HS.584406 1.32 3.97 -0.37 1.00 0.42 1 2 3 4 5 -4.34 4.34 FER1L4 0.69 3.58 -0.77 -0.11 0.28 1 2 3 4 5 -4.35 4.35 HS.580749 -0.30 3.64 -0.72 -0.08 -1.11 1 2 3 4 5 -4.36 4.36 ADH1A 0.82 4.72 0.36 0.80 0.28 1 2 3 4 5 -4.36 4.36 HS.562048 1.05 5.99 1.63 -0.23 -0.70 1 2 3 4 5 -4.36 4.36 HS.86941 3.98 3.69 -0.68 -0.25 -0.06 1 2 3 4 5 -4.38 4.38 MMP7 -0.19 3.06 -1.32 0.00 -0.92 1 2 3 4 5 -4.38 4.38 HS.544044 -0.31 3.86 -0.53 2.68 -0.63 1 2 3 4 5 -4.39 4.39 GBP7 1.63 4.11 -0.33 0.17 -0.82 1 2 3 4 5 -4.44 4.44 HS.212483 0.94 3.89 -0.56 3.79 1.72 1 2 3 4 5 -4.45 4.45 HS.98004 -0.07 3.74 -0.72 -0.70 -1.12 1 2 3 4 5 -4.45 4.45 ATOH1 -0.15 3.66 -0.80 0.92 0.37 1 2 3 4 5 -4.46 4.46 OR7A10 0.17 4.08 -0.38 -0.69 -0.41 1 2 3 4 5 -4.47 4.47 Table 3 179 HS.540372 0.24 4.64 0.17 2.08 -2.69 1 2 3 4 5 -4.47 4.47 SPANXN2 1.78 4.37 -0.10 6.94 0.67 1 2 3 4 5 -4.47 4.47 HS.580561 0.60 3.57 -0.90 -1.08 -0.32 1 2 3 4 5 -4.47 4.47 CP 0.74 4.44 -0.04 0.94 -0.34 1 2 3 4 5 -4.47 4.47 HS.542479 1.34 5.29 0.81 1.25 0.95 1 2 3 4 5 -4.48 4.48 LOC651381 3.68 3.08 -1.41 0.30 2.93 1 2 3 4 5 -4.49 4.49 ANTXRL 2.58 3.93 -0.57 1.52 0.70 1 2 3 4 5 -4.51 4.51 HS.378923 0.05 5.50 0.99 0.18 0.25 1 2 3 4 5 -4.51 4.51 LOC652856 -0.23 4.74 0.22 0.35 -0.05 1 2 3 4 5 -4.51 4.51 EYA1 -0.41 5.86 1.35 -1.97 0.72 1 2 3 4 5 -4.52 4.52 HS.546134 0.04 4.77 0.25 -0.73 -0.55 1 2 3 4 5 -4.52 4.52 HS.511485 1.91 6.26 1.74 -0.05 -0.54 1 2 3 4 5 -4.52 4.52 HS.571445 1.40 4.37 -0.16 4.35 0.34 1 2 3 4 5 -4.53 4.53 F0XR2 -0.33 4.59 0.04 0.48 1.73 1 2 3 4 5 -4.54 4.54 LOH3CR2A -0.52 5.22 0.66 0.22 -0.54 1 2 3 4 5 -4.55 4.55 HS.580377 0.54 6.05 1.50 -0.17 -0.31 1 2 3 4 5 -4.56 4.56 HS.581476 0.49 3.73 -0.85 -0.19 0.33 1 2 3 4 5 -4.58 4.58 HS.576427 -1.01 6.45 1.87 0.89 -0.03 1 2 3 4 5 -4.58 4.58 ARTN 2.81 4.22 -0.38 0.70 0.51 1 2 3 4 5 -4.59 4.59 LOC338805 2.44 4.76 0.14 4.46 1.24 1 2 3 4 5 -4.62 4.62 CALR3 2.55 5.05 0.42 1.36 1.52 1 2 3 4 5 -4.63 4.63 HS.577706 1.02 5.56 0.93 -0.43 0.91 1 2 3 4 5 i -4.63 4.63 ALOX12P2 0.48 4.23 -0.41 2.12 0.95 1 2 3 4 5 -4.64 4.64 LOC651345 1.13 4.12 -0.52 5.00 0.80 1 2 3 4 5 : -4.64 4.64 HS.554717 -0.55 4.37 -0.28 0.23 1.74 1 2 3 4 5 -4.65 4.65 HS.513113 1.98 4.78 0.12 0.74 0.33 1 2 3 4 5 -4.66 4.66 L0C441424 -2.27 3.67 -0.99 7.25 -1.53 1 2 3 4 5 -4.67 4.67 CSPG5 1.81 4.39 -0.32 0.26 0.40 1 2 3 4 -4.70 4.70 HS.145141 2.14 4.81 0.09 1.30 0.66 1 2 3 4 5 : -4.73 4.73 HS.579364 3.31 3.75 -1.01 0.63 0.62 1 2 3 4 5 -4.75 4.75 HS.565435 1.91 4.49 -0.28 0.86 -0.10 1 2 3 4 5 -4.77 4.77 HS.555589 -0.30 4.42 -0.34 -0.04 -0.17 1 2 3 4 5 -4.77 4.77 HS.134634 2.68 5.27 0.49 -0.20 1.51 1 2 3 4 5 -4.78 4.78 LOC554226 -2.04 1.16 -3.64 1.33 5.86 1 2 3 4 5 -4.80 4.80 HS.570004 -1.85 2.62 -2.19 2.45 0.97 1 2 3 4 5 -4.80 4.80 MUPCDH 0.07 4.86 0.05 -0.87 -0.02 1 2 3 4 -4.81 4.81 KRTHA5 1.01 5.51 0.70 0.59 0.38 1 2 3 4 5 -4.81 4.81 HS.105147 1.96 4.20 -0.62 -0.20 -0.75 1 2 3 4 5 -4.83 4.83 LOC388199 0.85 3.09 -1.76 1.94 -1.36 1 2 3 4 5 -4.85 4.85 OR56A3 -0.32 5.52 0.67 1.58 2.16 1 2 3 4 5 -4.85 4.85 HS.104829 1.23 5.12 0.24 -0.32 2.21 1 2 3 4 5 -4.87 4.87 C20RF13 2.32 3.89 -1.00 0.76 1.71 1 2 3 4 • 5 -4.88 4.88 MGC39584 1.15 2.91 -1.99 -1.14 -1.63 1 2 3 4 5 -4.90 4.90 HS.44210 2.25 5.76 0.85 -0.32 -1.77 1 2 3 4 5 -4.91 4.91 HS. 580449 -0.98 4.51 -0.41 0.38 0.22 1 2 3 4 5 -4.92 4.92 HS.552249 0.05 4.75 -0.21 0.32 -0.24 1 2 3 4 5 -4.96 4.96 LOC642120 -0.15 4.96 0.00 -0.67 0.61 1 2 3 4 5 -4.97 4.97 LOC652667 -0.20 4.85 -0.12 -0.66 0.05 1 2 3 4 5 -4.97 4.97 HS.549742 0.94 4.47 -0.50 -0.23 -0.47 1 2 3 4 5 -4.97 4.97 Table 3 180 HS.364104 0.82 5.96 0.98 -1.75 0.24 1 2 3 4 5 -4.98 4.98 PROX1 0.78 3.82 -1.17 -0.35 -0.05 1 2 3 4 5 -4.99 4.99 HS.312166 1.90 4.79 -0.22 0.12 -0.43 1 2 3 4 5 -5.01 5.01 CELP -0.90 4.29 -0.72 -0.90 1.89 1 2 3 4 5 -5.01 5.01 LOC646580 0.99 4.43 -0.59 0.01 -0.12 1 2 3 4 5 -5.02 5.02 HS.581525 1.37 4.01 -1.02 0.11 -0.25 1 2 3 4 5 -5.03 5.03 HS.232230 -1.03 4.50 -0.53 1.36 -1.02 1 2 3 4 5 -5.04 5.04 CRTAC1 0.56 6.45 1.40 1.16 -0.34 1 2 3 4 5 -5.05 5.05 HS.545273 -0.31 4.63 -0.42 -0.76 2.29 1 2 3 4 5 -5.06 5.06 KCNA2 0.03 4.66 -0.41 2.78 -1.43 1 2 3 4 5 -5.07 5.07 PKD1L2 -0.63 3.43 -1.64 -1.13 1.00 1 2 3 4 5 -5.07 5.07 LOC439985 2.50 6.15 1.07 -0.53 -0.76 1 2 3 4 5 -5.07 5.07 AKAP14 3.86 4.60 -0.47 0.23 1.98 1 2 3 4 5 -5.08 5.08 HS.46756 -1.05 6.74 1.66 0.23 1.85 1 2 3 4 5 -5.08 5.08 HTR3E -0.70 4.87 -0.24 0.12 0.02 1 2 3 4 5 -5.11 5.11 LOC653651 -0.42 4.31 -0.81 -0.80 0.27 1 2 3 4 5 -5.12 5.12 LOC120824 0.31 5.34 0.22 1.20 -0.24 1 2 3 4 5 -5.12 5.12 LOC647869 0.83 5.15 0.03 -0.07 -0.38 1 2 3 4 5 -5.13 5.13 TNRC9 1.06 2.58 -2.55 1.71 1.65 1 2 3 4 5 -5.13 5.13 SLC2A7 3.91 6.03 0.88 0.15 0.10 1 2 3 4 5 -5.15 5.15 HS.132478 1.80 3.94 -1.22 2.02 0.84 1 2 3 4 5 -5.16 5.16 LOC389105 0.78 5.67 0.52 2.49 0.16 1 2 3 4 5 -5.16 5.16 HS.535826 0.21 3.85 -1.31 2.03 0.23 1 2 3 4 5 -5.16 5.16 LOC650905 4.26 5.22 0.04 -0.11 2.76 1 2 3 4 5 -5.18 5.18 HS.544289 -0.31 5.17 -0.02 0.85 -0.57 1 2 3 4 5 -5.20 5.20 LOC644420 -0.47 5.04 -0.16 1.42 -0.58 1 2 3 4 5 -5.20 5.20 LOC286094 -1.47 3.84 -1.37 3.39 -0.93 1 2 3 4 5 -5.21 5.21 HS.576685 -0.95 3.55 -1.67 -0.05 0.42 1 2 3 4 5 -5.22 5.22 ASXL3 0.27 4.35 -0.91 -0.35 0.25 1 2 3 4 5 -5.25 5.25 FAM13C1 -0.71; 3.65 -1.61 -1.40 7.03 1 2 3 4 5 -5.26 5.26 HS.254632 1.90 3.27 -2.04 1.09 0.13 1 2 3 4 5 -5.31 5.31 PRM2 0.24 3.53 -1.80 -0.63 -1.42 1 2 3 4 5 -5.33 5.33 NRAP -1.13 3.51 -1.85 -0.71 -1.28 1 2 3 4 5 -5.37 5.37 C60RF123 3.80 5.24 -0.15 1.59 2.46 1 2 3 4 5 -5.39 5.39 LOC645537 0.99 4.62 -0.77 -0.72 2.97 1 2 3 4 5 -5.40 5.40 HS.428820 -0.03 5.33 -0.08 0.00 -0.12 1 2 3 4 5 -5.41 5.41 HS.53687 1.82 6.15 0.74 0.12 1.03 1 2 3 4 5 -5.41 5.41 PTCHD1 0.79 4.68 -0.75 3.38 0.58 1 2 3 4 5 -5.43 5.43 HS. 544544 -0.87 4.26 -1.19 1.84 -0.09 1 2 3 4 5 -5.45 5.45 HS.319720 -0.22 4.24 -1.25 1.31 -0.89 1 2 3 4 5 -5.49 5.49 HS.570717 2.46 4.40 -1.11 3.23 0.83 1 2 3 4 5 -5.50 5.50 HS.545103 0.13 5.42 -0.08 1.76 0.05 1 2 3 4 5 -5.51 5.51 HS.581453 3.62 5.55 0.03 4.10 2.24 1 2 3 4 5 -5.52 5.52 FU33651 0.90 5.55 0.02 0.16 1.37 1 2 3 4 5 -5.53 5.53 PHOSPHOl 0.16 5.59 0.05 0.25 -0.41 1 2 3 4 5 -5.54 5.54 C20ORF152 -1.43 5.10 -0.44 0.43 0.60 1 2 3 4 5 -5.55 5.55 DZIP1 -0.76 5.06 -0.53 2.28 0.49 1 2 3 4 5 -5.60 5.60 HS.551381 5.07 6.41 0.80 -0.05 -0.80 1 2 3 4 5 -5.60 5.60 HS.172608 -0.13 5.39 -0.22 0.62 2.20 1 2 3 4 5 -5.61 5.61 Table 3 181 HS.563049 0.85 5.57 -0.03 0.69 -0.55 1 2 3 4 5 -5.61 5.61 LOC652463 0.70 5.75 0.14 -0.11 -0.04 1 2 3 4 5 -5.61 5.61 HS.556937 0.17 4.95 -0.69 1.83 -0.22 1 2 3 4 5 -5.64 5.64 APC2 0.22 5.43 -0.21 0.52 0.09 1 2 3 4 5 -5.65 5.65 HS.564595 3.30 4.62 -1.06 0.24 1.37 1 2 3 4 5 -5.69 5.69 LOC164380 -1.06 4.11 -1.57 0.71 -0.23 1 2 3 4 5 -5.69 5.69 OSMR -0.88 4.17 -1.55 -1.01 2.03 1 2 3 4 5 -5.72 5.72 HS.566710 -0.91 4.96 -0.77 -0.68 -1.03 1 2 3 4 j -5.73 5.73 HS.569320 1.05 4.97 -0.77 5.01 3.20 1 2 3 4 5 -5.74 5.74 C60RF155 0.58 5.27 -0.48 -0.14 -0.08 1 2 3 4 5 -5.75 5.75 LOC643253 -0.35 4.83 -0.92 2.03 0.11 1 2 3 4 5 -5.75 5.75 HS.550449 1.02 5.60 -0.18 0.31 3.97 1 2 3 4 5 -5.78 5.78 HS.580543 -0.52 5.33 -0.46 -0.15 -1.63 1 2 3 4 5 -5.79 5.79 GCNT3 0.55 5.99 0.19 0.45 0.58 1 2 3 4 5 -5.80 5.80 SFTPA2B -0.84 5.54 -0.31 -0.52 -0.36 1 2 3 4 5 -5.85 5.85 HS.526433 1.27 6.38 0.53 -0.76 0.94 1 2 3 4 5 -5.85 5.85 HS.243488 -0.73 5.11 -0.76 1.61 1.21 1 2 3 4 5 -5.87 5.87 GULP1 -0.76 4.33 -1.56 -0.55 -0.54 1 2 3 4 5 -5.89 5.89 HS.541425 2.31 4.97 -0.92 -0.75 1.86 1 2 3 4 5 -5.89 5.89 HS.583715 -0.65 5.19 -0.72 -0.39 -0.23 1 2 3 4 5 -5.91 5.91 HS.541707 -0.14 5.28 -0.67 0.38 -1.18 1 2 3 4 5 -5.95 5.95 FHOD3 1.14 5.14 -0.82 -0.05 0.25 1 2 3 4 5 -5.96 5.96 HS.194988 -0.61 4.42 -1.56 0.85 -0.14 1 2 3 4 5 -5.98 5.98 TEKT5 -0.32 4.32 -1.68 0.40 -0.12 1 2 3 4 5 -6.00 6.00 HS.551300 -0.21 5.67 -0.36 -0.43 0.07 1 2 3 4 5 -6.03 6.03 HS.543006 0.40 5.70 -0.33 -0.49 0.49 1 2 3 4 5 -6.04 6.04 OR2L8 1.41 6.08 0.03 0.63 -0.77 1 2 3 4 5 -6.05 6.05 HS.562547 -0.52 6.38 0.32 -0.93 -0.68 1 2 3 4 5 -6.06 6.06 HS.545446 1.14 6.22 0.15 0.89 0.45 1 2 3 4 5 -6.07 6.07 FAM46D 0.94 5.98 -0.10 3.13 -1.06 1 2 3 4 5 -6.08 6.08 HS. 164344 0.97 5.22 -0.88 -0.84 0.99 1 2 3 4 5 -6.10 6.10 LOC645953 1.01 6.43 0.28 -0.16 -1.00 1 2 3 4 5 -6.15 6.15 OR2M7 -0.91 6.16 0.01 2.63 3.69 1 2 3 4 5 -6.15 6.15 HS.574704 -0.02 5.37 -0.78 1.50 1.14 1 2 3 4 5 -6.15 6.15 LOC648628 -1.06 6.34 0.17 -1.58 1.06 1 2 3 4 5 -6.17 6.17 LOC646905 1.04 6.21 0.03 0.13 -0.13 1 2 3 4 5 -6.17 6.17 HS.582715 0.33 4.36 -1.82 1.30 -0.17 1 2 3 4 5 -6.18 6.18 HS.116593 0.81 5.13 -1.05 -0.19 -0.98 1 2 3 4 5 -6.18 6.18 ABCG2 -0.27 5.24 -0.97 0.70 2.84 1 2 3 4 5 i -6.22 6.22 HS.542465 0.64 5.89 -0.33 -0.16 1.01 1 2 3 4 5 -6.22 6.22 HS.543273 1.85 5.67 -0.59 -0.16 0.00 1 2 3 4 5 -6.26 6.26 HS.570880 -0.64 5.60 -0.67 -0.03 -1.15 1 2 3 4 5 -6.28 6.28 SSX8 -1.81 4.60 -1.69 -1.83 0.35 1 2 3 4 5 -6.29 6.29 HS.104789 1.31 6.13 -0.30 -0.51 0.03 1 2 3 4 5 -6.42 6.42 HS.564196 0.11 5.66 -0.81 2.86 2.70 1 2 3 4 5 -6.47 6.47 LOC648050 1.28 6.05 -0.42 0.43 -0.49 1 2 3 4 5 -6.47 6.47 MY018B 0.29 4.50 -1.98 -1.10 -1.44 1 2 3 4 5 -6.48 6.48 LOC652454 5.04 5.12 -1.41 0.78 1.10 1 2 3 4 5 -6.53 6.53 HS.13480 0.97 5.62 -0.92 1.83 0.08 1 2 3 4 5 -6.54 6.54 Table 3 182 KRTAP2-2 -1.04 6.68 0.07 1.56 0.73 1 2 3 4 5 -6.61 6 61 FU45721 0.54 6.44 -0.21 0.01 0.66 1 2 3 4 5 -6.65 6 65 LOC649775 -0.06 6.12 -0.58 -1.17 0.68 1 2 3 4 5 -6.70 6 70 LOC642140 -1.44 6.17 -0.65 -1.08 -1.52 1 2 3 4 5 -6.81 6 81 TYR03P -1.39 6.21 -0.61 -0.57 -2.00 1 2 3 4 5 -6.81 6 81 MS4A6E -0.15 6.25 -0.61 -0.27 1.57 1 2 3 4 5 -6.86 6 86 HS.332123 -1.32 6.17 -0.84 0.29 -0.29 1 2 3 4 5 -7.02 7 02 F10 2.26 6.58 -0.45 1.05 3.10 1 2 3 4 5 -7.03 7 03 HS.566685 0.79 7.36 0.30 1.34 1.90 1 2 3 4 5 -7.05 7 05 LOC652097 -0.29 7.33 -0.03 1.84 -0.19 1 2 3 4 5 -7.36 7 36 HS.567201 0.16 6.64 -0.75 0.82 -0.36 1 2 3 4 5 -7.38 7 38 GPR88 0.72 7.36 -0.09 -0.51 -0.48 1 2 3 4 5 -7.45 7 45 HS.463556 0.63 8.19 -1.04 -0.67 1.68 1 2 3 4 5 -9.23 9 23 IL1F10 -1.41 10.04 -1.57 3.04 1.44 1 2 3 4 5 -11.60 11 60 THIS PAGE IS LEFT INTENTIONALLY BLANK Table 4 184

Target ID z wk 1 z wk 2 z wk 3 z wk 4 z wk 5 wk 1 wk 2 3 wk 4 wk 5 m abs(m) CDH8 -1.87 -1.85 -1.08 7.78 0.07 1 2 3 4 5 4.82 4.82 SLC15A1 2.53 -0.46 0.33 8.20 3.52 1 2 3 4 5 4.33 4.33 HS.545878 1.53 0.43 0.67 8.90 0.69 1 2 3 4 5 4.23 4.23 PGA4 -1.35 -0.54 0.31 7.73 4.44 1 2 3 4 5 4.14 4.14 PCDH8 1.91 -0.63 0.34 7.50 0.64 1 2 3 4 5 4.07 4.07 IFNA17 -1.47 -0.48 1.42 7.55 0.44 1 2 3 4 5 4.01 4.01 DNAH11 -1.61 -0.55 -0.51 7.35 2.32 1 2 3 4 5 3.95 3.95 TBC1D8B -1.06 -0.89 0.40 6.98 -0.86 1 2 3 4 5 3.94 3.94 ANKRD20B -0.48 -1.15 -0.70 6.71 -1.98 1 2 3 4 5 3.93 3.93 LEMD1 1.28 -1.43 1.74 6.26 2.86 1 2 3 4 5 3.85 3.85 LOC389362 1.41 -0.55 -0.43 6.95 1.91 1 2 3 4 5 3.75 3.75 PGF 0.75 -1.24 1.41 6.15 -0.46 1 2 3 4 5 3.70 3.70 HS. 129003 -0.39 -1.89 -0.12 5.40 2.65 1 2 3 4 5 3.64 3.64 HS.529442 1.99 0.17 0.49 7.39 -1.15 1 2 3 4 5 3.61 3.61 HS.553144 1.96 -1.03 -0.20 6.13 -0.50 1 2 3 4 5 3.58 3.58 HS.561669 1.43 -0.78 4.00 6.15 -0.46 1 2 3 4 5 3.46 3.46 LOC653527 1.05 -0.32 2.59 6.60 2.44 1 2 3 4 5 3.46 3.46 C100RF115 1.15 -3.18 2.05 3.72 1.24 1 2 3 4 5 3.45 3.45 LOC649783 0.39 -0.76 -0.09 6.01 -0.46 1 2 3 4 5 3.39 3.39 PDE6C 0.31 -0.81 1.81 5.93 3.59 1 2 3 4 5 3.37 3.37 HS.540859 3.90 -1.53 0.18 5.16 2.37 1 2 3 4 5 3.35 3.35 HS.564530 -0.33 -0.33 -0.24 6.35 -0.42 1 2 3 4 5 3.34 3.34 SNORD42A 0.60 -1.50 2.16 5.12 1.39 1 2 3 4 5 3.31 3.31 HS.563087 -0.76 -0.54 0.77 5.99 0.81 1 2 3 4 5 3.27 3.27 HS.580716 0.03 -0.98 -0.14 5.51 -0.03 1 2 3 4 5 3.24 3.24 HS.549727 -0.63 -1.93 -0.29 4.48 -0.26 1 2 3 4 5 3.20 3.20 VCY1B -0.81 -1.43 0.80 4.90 0.45 1 2 3 4 5 3.17 3.17 MIP -1.37 -1.33 -0.19 4.88 1.24 1 2 3 4 5 3.10 3.10 ZPLD1 -1.95 -3.05 1.63 3.14 0.54 1 2 3 4 5 3.10 3.10 0R5AY1 -1.26 -0.48 -0.18 5.70 3.27 1 2 3 4 5 3.09 3.09 CNBD1 -0.14 -2.04 1.97 4.09 1.32 1 2 3 4 5 3.06 3.06 PDCD1LG2 -1.74 -3.02 -1.97 3.10 -1.41 1 2 3 4 5 3.06 3.06 HS.582245 0.12 2.05 4.32 7.99 -0.28 1 2 3 4 5 2.97 2.97 HS.559248 -1.20 -1.49 1.56 4.43 1.12 1 2 3 4 5 2.96 2.96 KRT40 -0.32 -2.15 -1.21 3.72 -1.24 1 2 3 4 5 2.94 2.94 FU23172 -1.02 -0.86 0.59 4.87 -0.82 1 2 3 4 5 2.86 2.86 ESC02 0.57 -0.99 1.75 4.73 -0.08 1 2 3 4 5 2.86 2.86 LOC652369 -0.83 -0.93 -0.07 4.76 1.02 1 2 3 4 5 2.85 2.85 DSCAML1 0.94 -0.74 0.47 4.94 3.69 1 2 3 4 5 2.84 2.84 HS.543990 0.70 -1.11 -0.89 4.50 1.13 1 2 3 4 5 2.81 2.81 LOC652857 0.00 -1.23 -0.49 4.37 0.13 1 2 3 4 5 2.80 2.80 HS.437939 0.45 -0.32 0.03 5.26 -0.13 1 2 3 4 5 2.79 2.79 HS.580465 1.97 -0.13 3.06 5.43 0.33 1 2 3 4 5 2.78 2.78 HS.435075 1.19 2.92 5.08 8.35 0.24 1 2 3 4 5 2.72 2.72 HS.539814 1.60 -0.57 2.00 4.83 -0.88 1 2 3 4 5 2.70 2.70 HS.547695 0.95 -1.06 -0.04 4.30 -0.26 1 2 3 4 5 2.68 2.68 HS.541821 0.89 -0.86 0.48 4.45 0.88 1 2 3 4 5 2.66 2.66 G0T1L1 0.80 -0.52 2.26 4.73 0.10 1 2 3 4 5 2.62 2.62 Table 4 185

HS.569128 1.07 -0.65 -0.22 4.59 -0.05 1 2 3 4 5 2.62 2.62 LOC644288 1.22 -1.29 1.02 3.90 0.01 1 2 3 4 5 2.59 2.59 HS.570433 0.30 -1.77 -1.37 3.39 3.67 1 2 3 4 5 2.58 2.58 HS.543613 2.41 0.37 1.20 5.51 0.01 1 2 3 4 5 2.57 2.57 HS.474112 0.86 -0.60 1.16 4.53 1.95 1 2 3 4 5 2.57 2.57 HS.577389 1.09 0.20 1.69 5.29 0.45 1 2 3 4 5 2.55 2.55 HS.578028 0.78 -0.06 0.41 5.00 0.24 1 2 3 4 5 2.53 2.53 PTPN21 0.12 -0.74 -0.60 4.32 0.07 1 2 3 4 5 2.53 2.53 CLLU1 0.50 -1.61 -0.93 3.40 1.58 1 2 3 4 5 2.51 2.51 XAGE5 -2.02 -2.58 0.31 2.43 1.01 1 2 3 4 5 2.51 2.51 HS.156213 -0.37 0.08 3.65 5.09 0.86 1 2 3 4 5 2.50 2.50 PNLIPRP3 0.01 -0.21 1.39 4.79 2.10 1 2 3 4 5 2.50 2.50 C10RF189 -0.27 -0.75 -0.10 4.24 0.56 1 2 3 4 5 2.49 2.49 HS.476854 -0.85 -0.08 1.27 4.87 4.37 1 2 3 4 5 2.48 2.48 ARHGAP8 -0.74 -0.64 -0.14 4.30 0.20 1 2 3 4 5 2.47 2.47 PLXNA4B -0.59 -1.67 -0.41 3.24 2.46 1 2 3 4 5 2.46 2.46 HS.540568 0.53 -2.17 -1.58 2.71 0.91 1 2 3 4 5 2.44 2.44 LOC650330 -0.80 -0.51 0.39 4.36 0.04 1 2 3 4 5 2.44 2.44 HS.583877 0.52 -0.92 0.61 3.95 0.41 1 2 3 4 5 2.44 2.44 HS.563031 1.61 0.16 0.39 5.01 0.58 1 2 3 4 5 2.43 2.43 HS.543074 -0.57 -0.97 -0.26 3.88 0.81 1 2 3 4 5 2.42 2.42 LOC644408 0.21 0.35 0.49 5.15 2.75 1 2 3 4 5 2.40 2.40 HS.411472 -1.70 -0.58 2.22 4.21 0.88 1 2 3 4 5 2.40 2.40 LOC642370 -0.53 -1.06 -0.62 3.70 0.70 1 2 3 4 5 2.38 2.38 HS.560432 0.53 1.05 3.42 5.82 4.09 1 2 3 4 5 2.38 2.38 LOC645645 0.83 -1.56 -0.15 3.15 1.98 1 2 3 4 5 2.36 2.36 HS.543642 -1.26 -1.62 0.28 3.09 0.22 1 2 3 4 5 2.36 2.36 HS.581199 0.26 -3.05 -2.20 1.64 0.63 1 2 3 4 5 2.34 2.34 TCTE1 -0.27 -1.62 -1.18 3.03 0.81 1 2 3 4 5 2.33 2.33 DEFA6 1.04 -1.13 2.34 3.52 0.93 1 2 3 4 5 2.32 2.32 HS.147755 -0.29 -0.90 -0.72 3.75 0.30 1 2 3 4 5 2.32 2.32 HS.126962 0.09 0.07 1.54 4.71 1.77 1 2 3 4 5 2.32 2.32 HS.544896 1.59 0.40 3.90 5.01 0.52 1 2 3 4 5 2.31 2.31 ZNF678 2.54 -3.28 0.69 1.31 3.13 1 2 3 4 5 2.30 2.30 RBM 0.95 -1.46 0.79 3.12 0.25 1 2 3 4 5 2.29 2.29 HS.497583 4.11 -1.74 -0.54 2.83 0.93 1 2 3 4 5 2.29 2.29 LOC402634 0.27 -0.56 3.77 3.99 2.86 1 2 3 4 5 2.28 2.28 HS.127127 0.60 -0.65 -0.12 3.90 0.34 1 2 3 4 5 2.28 2.28 LOC643920 -1.18 -0.76 0.25 3.76 1.24 1 2 3 4 5 2.26 2.26 RIT2 -0.63 0.41 3.13 4.91 1.88 1 2 3 4 5 2.25 2.25 HS.565080 0.40 -1.33 -0.35 3.17 0.24 1 2 3 4 5 2.25 2.25 LOC647008 -0.23 -0.81 -0.46 3.68 0.83 1 2 3 4 5 2.24 2.24 HS.447731 -0.76 -0.63 0.19 3.84 0.11 1 2 3 4 5 2.24 2.24 C7 -1.10 -0.86 -0.84 3.60 0.22 1 2 3 4 5 2.23 2.23 HS.502618 0.71 -1.36 -0.28 3.08 0.70 1 2 3 4 5 2.22 2.22 HS.545855 0.80 -0.41 0.03 4.03 0.52 1 2 3 4 5 2.22 2.22 LOC651565 -0.55 0.14 0.91 4.55 0.51 1 2 3 4 5 2.20 2.20 RGS20 -1.41 -0.27 1.42 4.14 0.05 1 2 3 4 5 2.20 2.20 HS.576509 -0.47 -0.56 0.76 3.84 -0.43 1 2 3 4 5 2.20 2.20 Table 4 186

IL21 1.63 -0.38 1.90 3.99 -0.16 1 2 3 4 5 2.19 2.19 HS.537103 2.49 -0.84 0.38 3.52 1.77 1 2 3 4 5 2.18 2.18 HS.439512 1.28 -0.89 2.54 3.46 -0.32 1 2 3 4 5 2.18 2.18 ARNT2 -0.73 -0.88 -0.39 3.47 2.96 1 2 3 4 5 2.17 2.17 NUP210L -0.59 -1.00 1.11 3.34 -0.22 1 2 3 4 5 2.17 2.17 PMCH 0.09 -1.00 0.17 3.34 -1.06 1 2 3 4 5 2.17 2.17 LOC652747 -0.45 -0.25 0.49 4.07 -0.30 1 2 3 4 5 2.16 2.16 HS.567132 0.33 0.07 0.17 4.39 0.74 1 2 3 4 5 2.16 2.16 OR13C5 0.85 -0.96 1.61 3.36 2.09 1 2 3 4 5 2.16 2.16 TMEM200B -0.02 -0.83 3.36 3.49 0.39 1 2 3 4 5 2.16 2.16 HS.189824 4.49 -1.33 0.15 2.99 -1.37 1 2 3 4 5 2.16 2.16 ASZ1 -0.19 -0.12 0.45 4.18 0.25 1 2 3 4 5 2.15 2.15 ASPA 0.44 -1.66 -0.69 2.63 -0.12 1 2 3 4 5 2.15 2.15 HS.565636 -0.05 -0.66 0.79 3.60 0.99 1 2 3 4 5 2.13 2.13 LOC642646 -0.21 -1.24 -0.77 3.01 -1.13 1 2 3 4 5 2.13 2.13 LOC643140 0.15 -0.68 -0.30 3.57 -0.27 1 2 3 4 5 2.13 2.13 ADAD1 -1.52 -0.68 2.74 3.57 1.43 1 2 3 4 5 2.12 2.12 HS.540138 2.33 0.23 4.08 4.48 0.50 1 2 3 4 5 2.12 2.12 TUBAL3 -0.48 -1.08 -0.65 3.16 -0.32 1 2 3 4 5 2.12 2.12 WDR42B 4.49 -1.33 -0.72 2.90 2.56 1 2 3 4 5 2.12 2.12 HS.544468 1.91 -0.23 2.09 4.00 0.61 1 2 3 4 5 2.12 2.12 FLNC 0.47 -2.00 -0.19 2.23 0.23 1 2 3 4 5 2.11 2.11 LOC648900 0.11 -0.26 -0.09 3.95 2.22 1 2 3 4 5 2.11 2.11 HS3ST4 0.11 -0.29 0.30 3.92 0.47 1 2 3 4 5 2.11 2.11 REX01L1 -0.17 -1.25 -0.46 2.96 -0.62 1 2 3 4 5 2.10 2.10 DUSP21 -0.93 -1.15 -0.48 3.05 0.62 1 2 3 4 5 2.10 2.10 HS.565653 -0.67 -0.90 2.11 3.26 -0.56 1 2 3 4 5 2.08 2.08 KRTAP13-4 0.64 -0.09 1.60 4.07 0.74 1 2 3 4 5 2.08 2.08 HS.403966 -0.52 -0.93 -0.51 3.21 0.14 1 2 3 4 5 2.07 2.07 HS.569905 2.61 0.41 1.70 4.55 2.23 1 2 3 4 5 2.07 2.07 LOC645557 -0.64 -0.79 -0.57 3.35 -0.75 1 2 3 4 5 2.07 2.07 HS.571672 1.17 -1.38 0.39 2.75 -0.01 1 2 3 4 5 2.07 2.07 THY1 2.50 -1.52 -0.93 2.61 -0.47 1 2 3 4 5 2.06 2.06 HS.436880 -0.01 -0.20 0.09 3.92 1.98 1 2 3 4 5 2.06 2.06 KRT32 -0.54 -0.78 0.11 3.33 -0.64 1 2 3 4 5 2.06 2.06 LOC645078 -1.27 -1.52 -0.33 2.59 0.61 1 2 3 4 5 2.06 2.06 HS.573834 -0.11 0.79 4.55 4.89 -0.97 1 2 3 4 5 2.05 2.05 ALS2CR12 -0.23 -0.51 -0.22 3.58 -0.32 1 2 3 4 5 2.04 2.04 HS.455485 -0.97 -0.31 0.66 3.77 0.10 1 2 3 4 5 2.04 2.04 ATXN7 -0.40 -0.47 1.65 3.60 -0.60 1 2 3 4 5 2.03 2.03 HS.564219 -0.59 -0.51 -0.50 3.55 0.01 1 2 3 4 5 2.03 2.03 LOC643311 -0.12 -1.14 1.14 2.91 0.09 1 2 3 4 5 2.03 2.03 HS.562541 -0.33 -1.17 -0.31 2.87 -0.84 1 2 3 4 5 2.02 2.02 HS.352191 0.77 -0.22 1.47 3.82 -0.34 1 2 3 4 5 2.02 2.02 C40RF35 0.56 -0.43 0.86 3.60 0.74 1 2 3 4 5 2.02 2.02 HS.510641 -1.06 -0.79 0.24 3.24 -0.14 1 2 3 4 5 2.02 2.02 LOC647582 -0.67 -0.71 -0.33 3.32 3.50 1 2 3 4 5 2.01 2.01 C140RF177 0.05 -0.29 2.99 3.73 2.56 1 2 3 4 5 2.01 2.01 PPFIA2 1.79 -0.51 -0.43 3.51 -0.71 1 2 3 4 5 2.01 2.01 Table 4 187

HS.319265 0.53 -0.86 -0.29 3.13 -0.22 1 2 3 4 5 ; 2.00 2.00 HS. 108479 1.77 -0.64 -0.26 3.35 -0.16 1 2 3 4 5 2.00 2.00 HS.291069 -0.64 -0.57 -0.09 3.41 -0.32 1 2 3 4 5 1.99 1.99 HS.193480 -0.58 -0.66 -0.48 3.31 -0.98 1 2 3 4 5 1.99 1.99 OR5AP2 -1.02 -0.79 0.42 3.18 0.13 1 2 3 4 5 1.98 1.98 C190RF41 0.60 -1.09 0.56 2.87 1.07 1 2 3 4 5 1.98 1.98 OR2A12 1.91 -1.27 -0.82 2.67 -0.35 1 2 3 4 5 1.97 1.97 HS.195033 -0.34 -0.37 -0.16 3.57 -0.12 1 2 3 4 5 1.97 1.97 BRDT 1.05 -0.39 3.50 3.55 0.61 1 2 3 4 5 1.97 1.97 HS.452789 0.90 -0.46 0.58 3.44 -0.32 1 2 3 4 5 1.95 1.95 KRTAP3-2 -0.14 -0.50 0.02 3.40 1.24 1 2 3 4 5 1.95 1.95 HS.543378 -0.32 -0.67 -0.35 3.23 -0.92 1 2 3 4 5 1.95 1.95 HS.119921 -0.38 -0.49 0.19 3.40 0.03 1 2 3 4 5 1.94 1.94 HS.298112 2.65 0.06 1.14 3.94 -0.52 1 2 3 4 5 1.94 1.94 HS.563775 2.21 -0.61 0.82 3.28 -0.32 1 2 3 4 5 1.94 1.94 HS.580082 -0.48 -0.21 0.44 3.67 -0.75 1 2 3 4 5 1.94 1.94 HS.574966 0.25 0.52 0.88 4.39 2.36 1 2 3 4 5 1.94 1.94 HS.25028 1.64 0.27 0.98 4.13 2.94 1 2 3 4 5 1.93 1.93 HS.454803 1.21 -0.98 0.89 2.86 0.16 1 2 3 4 5 1.92 1.92 HS.540082 0.88 -1.21 0.14 2.63 0.11 1 2 3 4 5 1.92 1.92 HS.570624 1.24 -0.79 1.51 3.04 4.90 1 2 3 4 5 1.92 1.92 LOC344065 0.08 -0.09 0.10 3.73 0.02 1 2 3 4 5 1.91 1.91 TLL1 1.41 -1.80 -0.57 2.01 1.41 1 2 3 4 5 1.91 1.91 PCDHGA7 4.67 -2.67 -0.43 1.14 -1.09 1 2 3 4 5 1.91 1.91 0R1I1 1.69 -1.01 0.41 2.81 3.60 1 2 3 4 5 1.91 1.91 LOC645576 2.66 0.53 0.73 4.32 -0.03 1 2 3 4 5 1.90 1.90 HS.303880 -0.82 -0.11 1.49 3.67 -0.74 1 2 3 4 5 1.89 1.89 HS.524849 0.59 -0.77 0.39 3.00 0.41 1 2 3 4 5 1.89 1.89 HS.584144 -0.07 -0.07 0.88 3.68 -0.19 1 2 3 4 5 1.88 1.88 CHRNB2 1.18 -0.97 -0.91 2.76 3.16 1 2 3 4 5 1.87 1.87 ENTPD2 -0.74 -1.30 -0.81 2.43 2.35 1 2 3 4 5 1.86 1.86 CA7 1.28 -0.55 0.21 3.17 0.22 1 2 3 4 5 1.86 1.86 HS.163517 -0.03 3.11 6.65 6.82 2.04 1 2 3 4 5 1.86 1.86 OR7C1 0.51 -1.61 1.35 2.10 2.07 1 2 3 4 5 1.85 1.85 SNHG3 0.91 -0.38 1.19 3.32 -0.28 1 2 3 4 5 1.85 1.85 PLAU -0.47 -0.55 0.19 3.15 -0.36 1 2 3 4 5 1.85 1.85 PPP2R2C -0.84 -0.51 0.13 3.19 1.25 1 2 3 4 5 1.85 1.85 HS.119816 0.63 -1.64 0.18 2.06 3.43 1 2 3 4 5 1.85 1.85 LOC647366 -0.58 -0.60 0.40 3.10 1.66 1 2 3 4 5 1.85 1.85 HS.542299 -0.58 -0.76 -0.54 2.93 0.26 1 2 3 4 5 1.84 1.84 HS.581035 -1.27 -1.55 0.63 2.13 0.11 1 2 3 4 5 1.84 1.84 SLURP1 -0.91 -1.28 1.95 2.39 0.35 1 2 3 4 5 1.84 1.84 LOC653412 -0.46 -1.23 0.28 2.44 3.49 1 2 3 4 5 1.83 1.83 ANKRD31 1.17 -0.57 -0.41 3.09 1.90 1 2 3 4 5 1.83 1.83 FAT2 0.26 -1.43 -0.27 2.22 -0.42 1 2 3 4 5 1.82 1.82 HS.555149 -0.20 -0.47 0.35 3.18 1.76 1 2 3 4 5 1.82 1.82 OR51B6 -0.65 -1.76 0.57 1.87 3.76 1 2 3 4 5 1.81 1.81 PDE11A -0.34 -1.32 0.46 2.30 0.39 1 2 3 4 5 1.81 1.81 DLGAP3 -0.51 -0.76 0.68 2.85 0.84 1 2 3 4 5 1.81 1.81 Table 4 188

HS.539658 0.52 -0.73 2.31 2.88 -1.01 1 2 3 4 5 1.81 1.81 HS.434736 -1.21 -2.07 1.22 1.54 -1.02 1 2 3 4 5 1.81 1.81 HS.544108 -0.76 1.23 2.13 4.84 -0.14 1 2 3 4 5 1.81 1.81 HOXB13 0.19 0.44 0.89 4.05 0.26 1 2 3 4 5 1.80 1.80 HS.16633 -0.33 -0.93 1.06 2.67 -0.53 1 2 3 4 5 1.80 1.80 HS.161173 0.05 -0.17 1.23 3.42 0.28 1 2 3 4 5 1.79 1.79 VTCN1 1.10 -0.40 1.05 3.18 1.13 1 2 3 4 5 1.79 1.79 TAOK3 0.14 -0.72 0.65 2.86 0.67 1 2 3 4 5 1.79 1.79 CCL11 1.17 -1.04 -0.23 2.53 -1.47 1 2 3 4 5 1.79 1.79 LOC440309 0.77 -0.63 -0.18 2.93 1.50 1 2 3 4 5 1.78 1.78 LOC728003 4.05 -0.40 0.36 3.16 -0.20 1 2 3 4 5 1.78 1.78 EXDL1 0.70 -0.87 -0.62 2.69 -0.69 1 2 3 4 5 1.78 1.78 KCNJ6 -0.90 -0.97 2.03 2.59 -0.73 1 2 3 4 5 1.78 1.78 SPAG6 -0.25 -1.02 -0.52 2.53 0.17 1 2 3 4 5 1.78 1.78 C180RF58 -0.65 -0.61 0.30 2.94 -0.63 1 2 3 4 5 1.77 1.77 KRTAP5-5 -0.66 -0.86 -0.31 2.69 1.00 1 2 3 4 5 1.77 1.77 HIST3H2BB -0.38 -0.41 0.92 3.12 0.67 1 2 3 4 5 1.76 1.76 GLT8D4 0.61 -1.48 -1.07 2.05 0.36 1 2 3 4 5 1.76 1.76 LOC647212 0.47 -0.53 0.21 2.99 1.82 1 2 3 4 5 1.76 1.76 LOC642044 4.64 -0.46 0.50 3.05 2.22 1 2 3 4 5 1.76 1.76 HS.559742 -0.85 -1.79 1.23 1.72 -1.53 1 2 3 4 5 1.75 1.75 LOC644680 -0.63 -0.48 0.61 3.02 0.82 1 2 3 4 5 1.75 1.75 LOC389786 -0.11 -0.51 1.64 2.98 0.86 1 2 3 4 5 1.75 1.75 LOC283278 -0.14 -0.96 -0.67 2.53 -0.50 1 2 3 4 5 1.75 1.75 VGF 1.80 -0.08 1.19 3.41 0.13 1 2 3 4 5 1.75 1.75 TKTL2 -0.95 -0.94 0.13 2.55 -1.23 1 2 3 4 5 1.74 1.74 HS.566693 -0.33 -0.62 -0.48 2.87 0.67 1 2 3 4 5 1.74 1.74 OR52I2 1.09 -0.47 0.79 3.00 0.24 1 2 3 4 5 1.74 1.74 C220RF31 -1.27 -1.76 0.50 1.71 -0.31 1 2 3 4 5 1.74 1.74 LOC728601 -1.27 -1.53 0.23 1.94 -1.09 1 2 3 4 5 1.73 1.73 OR5K3 -0.44 -0.12 0.47 3.34 1.04 1 2 3 4 5 1.73 1.73 HS.130621 1.17 0.21 1.16 3.67 -1.43 1 2 3 4 5 1.73 1.73 MICAL3 2.78 -0.62 -0.55 2.84 0.31 1 2 3 4 5 1.73 1.73 ARNTL2 -0.58 -0.99 0.65 2.46 0.50 1 2 3 4 5 1.72 1.72 LOC728340 3.89 -0.59 2.08 2.84 -0.21 1 2 3 4 5 1.72 1.72 HS.538758 -0.15 -0.72 0.16 2.70 1.14 1 2 3 4 5 1.71 1.71 SEPP1 0.15 -0.03 0.06 3.38 2.34 1 2 3 4 5 1.70 1.70 PLEKHM3 -1.44 -0.73 -0.27 2.66 -0.64 1 2 3 4 5 1.69 1.69 LOC644204 -0.55 -0.05 0.65 3.34 -0.52 1 2 3 4 5 1.69 1.69 ARPP-21 -0.70 0.77 1.47 4.15 0.51 1 2 3 4 5 1.69 1.69 HS.580041 0.14 -0.58 0.17 2.80 -0.59 1 2 3 4 5 1.69 1.69 HS.544423 2.47 -0.36 0.12 3.01 0.43 1 2 3 4 5 1.68 1.68 HS.582647 0.32 -0.75 1.61 2.61 1.20 1 2 3 4 5 1.68 1.68 HS.542849 -0.44 -0.96 0.32 2.40 1.07 1 2 3 4 5 1.68 1.68 S100A7 -0.50 -1.57 0.29 1.78 2.31 1 2 3 4 5 1.68 1.68 HS.127773 0.48 0.21 0.21 3.56 2.34 1 2 3 4 5 1.68 1.68 HS.160301 1.10 -0.58 -0.40 2.77 0.12 1 2 3 4 5 1.68 1.68 LOC642681 1.22 -0.37 1.25 2.98 1.21 1 2 3 4 5 1.67 1.67 HS.582144 -0.17 -0.16 1.23 3.18 -0.29 1 2 3 4 5 1.67 1.67 Table 4 189 HS.200878 0.85 -0.58 1.50 2.76 -0.62 1 2 3 4 5 1.67 1.67 HS.570713 1.49 -0.76 0.72 2.58 0.29 1 2 3 4 5 1.67 1.67 LOC651655 4.27 -1.16 0.26 2.17 2.93 1 2 3 4 5 1.66 1.66 SYPL2 0.02 -2.23 -0.89 1.09 -1.99 1 2 3 4 5 1.66 1.66 HS.542855 -0.33 0.28 0.36 3.60 0.29 1 2 3 4 5 1.66 1.66 HS.576924 1.03 -1.36 -0.04 1.96 0.29 1 2 3 4 5 1.66 1.66 HS.570923 0.11 -0.77 -0.20 2.54 -0.42 1 2 3 4 5 1.65 1.65 NRXN3 -0.50 0.40 1.26 3.70 -0.30 1 2 3 4 5 1.65 1.65 ROB02 -0.73 -0.91 1.30 2.40 2.45 1 2 3 4 5 1.65 1.65 HS.583754 -0.42 -0.41 0.32 2.89 -0.52 1 2 3 4 5 1.65 1.65 HS.129583 -0.44 -0.07 0.10 3.22 -0.53 1 2 3 4 5 1.65 1.65 POF1B -0.40 -0.52 0.67 2.77 0.96 1 2 3 4 5 1.64 1.64 HS.552143 -0.32 -0.17 0.17 3.11 -0.31 1 2 3 4 5 1.64 1.64 HS.537547 0.90 -0.48 0.31 2.80 0.44 1 2 3 4 5 1.64 1.64 LOC646484 -0.10 -0.53 0.00 2.74 3.66 1 2 3 4 5 1.63 1.63 LOC644554 4.02 -0.60 1.69 2.67 -0.35 1 2 3 4 5 1.63 1.63 TRIM40 0.00 -0.05 0.93 3.22 -0.40 1 2 3 4 5 1.63 1.63 HS.136684 1.91 0.07 1.44 3.33 1.06 1 2 3 4 5 1.63 1.63 LOC648359 -0.74 -0.56 -0.35 2.69 0.61 1 2 3 4 5 1.63 1.63 NLRP6 -0.77 -0.72 1.98 2.54 0.10 1 2 3 4 5 1.63 1.63 LOC731438 0.51 -1.41 0.24 1.83 1.82 1 2 3 4 5 1.62 1.62 HS.434865 1.18 0.82 2.36 4.05 0.69 1 2 3 4 5 1.61 1.61 FGG 1.01 -0.13 1.21 3.09 -0.50 1 2 3 4 5 1.61 1.61 CCDC83 -1.70 -1.71 -1.55 1.51 -0.22 1 2 3 4 5 1.61 1.61 ATP4A 1.74 -0.82 -0.51 2.38 3.88 1 2 3 4 5 1.60 1.60 HS.97443 1.51 -1.43 -0.30 1.77 2.49 1 2 3 4 5 1.60 1.60 OR10K2 -2.06 -1.68 -1.00 1.51 2.66 1 2 3 4 5 1.60 1.60 HS.137641 -0.17 -0.60 0.08 2.59 -0.64 1 2 3 4 5 1.60 1.60 HS.334097 -0.08 -1.34 -1.21 1.85 -0.72 1 2 3 4 5 1.60 1.60 BPIL3 3.56 -0.23 1.05 2.96 -0.01 1 2 3 4 5 1.60 1.60 FU25770 4.80 -0.55 1.70 2.64 1.07 1 2 3 4 5 1.59 1.59 GRID1 0.47 0.00 0.66 3.19 -0.10 1 2 3 4 5 1.59 1.59 KRTAP5-2 -0.44 -1.00 -0.14 2.19 0.47 1 2 3 4 5 1.59 1.59 LOC652799 3.99 0.16 0.20 3.35 -0.24 1 2 3 4 5 1.59 1.59 ZIC3 1.10 -1.73 0.30 1.45 -0.73 1 2 3 4 5 1.59 1.59 HS.575187 -1.20 0.26 2.06 3.44 -0.81 1 2 3 4 5 1.59 1.59 HS.540201 3.37 -0.08 0.03 3.09 -0.04 1 2 3 4 5 1.59 1.59 LOC646372 0.28 -0.22 0.25 2.95 0.56 1 2 3 4 5 1.59 1.59 OR52E8 -1.75 0.14 0.86 3.31 3.13 1 2 3 4 5 1.58 1.58 OR4N5 -0.02 0.10 1.07 3.26 0.31 1 2 3 4 5 1.58 1.58 OR51S1 0.34 -0.98 -0.10 2.18 -0.57 1 2 3 4 5 1.58 1.58 HS.123362 -0.52 0.15 0.55 3.31 3.62 1 2 3 4 5 1.58 1.58 SSX1 -0.87 -0.90 0.61 2.26 0.24 1 2 3 4 5 1.58 1.58 HS.554391 1.14 -0.94 0.20 2.22 -1.84 1 2 3 4 5 1.58 1.58 KCTD19 0.28 -0.45 0.02 2.70 0.67 1 2 3 4 5 1.58 1.58 HS.584342 0.70 -1.11 1.43 2.04 0.41 1 2 3 4 5 1.57 1.57 LOC652620 -0.21 -2.03 -1.10 1.12 -0.28 1 2 3 4 5 1.57 1.57 HS.566881 -0.13 0.25 1.38 3.37 -0.02 1 2 3 4 5 1.56 1.56 HS.576677 -0.35 -1.05 -0.07 2.08 1.02 1 2 3 4 5 1.56 1.56 Table 4 190

HS.539367 2.51 -0.86 -0.62 2.25 1.45 1 2 3 4 5 ! 1.56 1.56 HS.116531 -0.61 -0.77 0.58 2.35 1.04 1 2 3 4 5 1.56 1.56 LOC646473 -0.91 -0.39 0.19 2.73 0.62 1 2 3 4 5 : 1.56 1.56 CA10 -0.80 - 0.33 0.81 3.45 -0.49 1 2 3 4 5 1.56 1.56 OR6C2 3.93 -0.96 -0.15 2.15 -0.91 1 2 3 4 5 1.55 1.55 TUBA4 1.74; -1.07 1.27 2.03 -0.72 1 2 3 4 5 1.55 1.55 HS.543727 1.09 0.28 1.43 3.38 -0.08 1 2 3 4 5 1.55 1.55 ATOH7 0.06 -1.00 -0.41 2.09 -0.75 1 2 3 4 1.54 1.54 LOC647989 1.45 1.90 2.56 4.98 1.77 1 2 3 4 5 1.54 1.54 HS.163781 -0.09 -0.54 0.43 2.54 2.96 1 2 3 4 5 1.54 1.54 LOC441795 -0.08 -0.39 0.18 2.69 0.28 1 2 3 4 5 1.54 1.54 LOC643081 -0.80 -0.37 1.32 2.70 0.10 1 2 3 4 5 1.53 1.53 H F4A -0.20 -0.23 -0.12 2.84 -0.07 1 2 3 4 5 1.53 1.53 HS.576319 0.18 -0.47 1.29 2.59 1.43 1 2 3 4 5 1.53 1.53 GAL -0.48 -1.20 1.39 1.86 -1.32 1 2 3 4 5 1.53 1.53 HS.580413 -1.04 -0.57 -0.40 2.48 1.26 1 2 3 4 5 1.53 1.53 HS.566614 -0.11 -0.31 -0.24 2.74 0.27 1 2 3 4 5 1.52 1.52 HS.545328 -0.07 0.38 1.54 3.42 -1.11 1 2 3 4 5 1.52 1.52 LOC653148 1.79 -0.29 0.55 2.76 -0.66 1 2 3 4 5 1.52 1.52 HS.554101 0.28 -0.29 0.90 2.75 0.98 1 2 3 4 5 1.52 1.52 HS.544526 2.01 -0.14 0.74 2.90 3.28 1 2 3 4 5 1.52 1.52 HS.435979 -0.63 -0.73 0.93 2.31 -0.07 1 2 3 4 5 1.52 1.52 HS.571643 -0.23 -0.56 1.57 2.47 2.62 1 2 3 4 5 1.52 1.52 ZIC1 -0.90 -1.03 -0.13 2.00 -0.44 1 2 3 4 5 1.52 1.52 AADACL4 0.75 -0.68 0.38 2.35 1.08 1 2 3 4 5 1.51 1.51 LOC649896 -0.40 -1.32 0.85 1.71 0.13 1 2 3 4 1.51 1.51 LOC196913 0.19 -0.35 0.22 2.68 -1.42 1 2 3 4 5 1.51 1.51 UCN2 -0.92 -1.38 -0.75 1.64 0.16 1 2 3 4 5 1.51 1.51 HS.546005 -0.98 -0.65 0.75 2.37 -0.59 1 2 3 4 5 1.51 1.51 LGR5 -0.33 -0.34 0.83 2.68 -0.72 1 2 3 4 5 1.51 1.51 HS.583949 0.70 0.45 1.57 3.47 0.21 1 2 3 4 5 1.51 1.51 HS.545305 -0.07 -0.88 0.87 2.14 1.35 1 2 3 4 5 1.51 1.51 HS.508828 -0.62 -0.45 0.14 2.57 -0.35 1 2 3 4 5 1.51 1.51 LOC652139 -0.05 0.22 0.77 3.24 3.48 1 2 3 4 5 1.51 1.51 LOC646947 1.68 -0.41 1.92 2.60 0.51 1 2 3 4 5 1.51 1.51 HS.560630 0.76 -0.89 0.60 2.12 -0.21 1 2 3 4 5 1.50 1.50 CKMT1B 2.36 -1.38 -1.03 1.62 1.01 1 2 3 4 5 1.50 1.50 HS.30495 1.15 1.05 1.80 4.05 0.39 1 2 3 4 5 1.50 1.50 HS.113577 1.16 -2.13 0.22 0.86 0.78 1 2 3 4 5 ! 1.50 1.50 DISC2 -0.55 0.60 1.49 3.59 1.43 1 2 3 4 5 1.50 1.50 OR9G4 -0.42 -0.52 -0.01 2.47 -1.06 1 2 3 4 1.49 1.49 SCGB2A1 0.70 -0.84 -0.41 2.15 -0.60 1 2 3 4 5 ; 1.49 1.49 KLHL10 -1.06 -1.27 -0.77 1.72 -0.08 1 2 3 4 5 1.49 1.49 RNF151 0.77 -1.26 1.43 1.72 -0.47 1 2 3 4 5 1.49 1.49 LOC644433 1.07 -0.41 0.40 2.57 0.25 1 2 3 4 5 1.49 1.49 HS.573580 -0.67 0.12 0.92 3.10 -0.79 1 2 3 4 5 1.49 1.49 HS.49962 -0.62 1.91 1.99 4.89 2.92 1 2 3 4 5 1.49 1.49 HS.562874 0.05 0.28 2.41 3.24 -0.24 1 2 3 4 5 1.48 1.48 HS.546046 -0.07 -0.96 0.73 1.99 0.62 1 2 3 4 5 1.48 1.48 Table 4 191 C120RF12 -0.32 -0.40 0.14 2.56 -0.78 1 2 3 4 5 1.48 1.48 HS.128107 1.06 -0.85 -0.51 2.10 -0.38 1 2 3 4 5 1.48 1.48 HS.575367 -1.17. -1.33 -0.72 1.62 -0.34 1 2 3 4 5 1.47 1.47 SH3D19 -0.35 -1.37 -0.92 1.57 -0.59 1 2 3 4 5 1.47 1.47 RAB9P1 -0.36 -0.60 -0.30 2.35 0.61 1 2 3 4 5 : 1.47 1.47 HS.552216 -0.41 -0.26 0.12 2.68 2.50 1 2 3 4 5 ; 1.47 1.47 HS.545073 3.30 -0.90 0.11 2.04 1.28 1 2 3 4 1.47 1.47 HS.258510 0.05 -0.52 -0.11 2.41 0.46 1 2 3 4 5 1.47 1.47 LOC653366 2.92 -0.58 -0.54 2.36 -0.53 1 2 3 4 5 1.47 1.47 C50RF38 -0.50 -0.61 0.41 2.32 -0.69 1 2 3 4 5 1.46 1.46 HS.576048 1.05 -0.55 0.13 2.38 2.22 1 2 3 4 5 1.46 1.46 LOC441097 2.38 -0.79 -0.18 2.13 -0.30 1 2 3 4 5 1.46 1.46 CACNG1 0.12 -1.75 -0.99 1.16 -0.75 1 2 3 4 5 1.46 1.46 HS.539225 -0.17 -0.67 0.24 2.24 -0.35 1 2 3 4 5 1.46 1.46 SPATA16 0.51 -0.31 1.37 2.60 -0.22 1 2 3 4 5 1.46 1.46 OR2T4 1.10 -1.09 -0.05 1.82 -0.65 1 2 3 4 5 1.45 1.45 OR2G6 2.38 -1.79 0.35 1.11 -0.04 1 2 3 4 5 1.45 1.45 HS.146758 2.67 -0.75 -0.21 2.15 -0.36 1 2 3 4 5 1.45 1.45 HS.140667 0.36 -0.29 2.03 2.60 0.23 1 2 3 4 5 1.45 1.45 PROZ -1.75 -0.30 1.04 2.58 -0.88 1 2 3 4 5 1.44 1.44 DUX4 -1.17 -0.18 0.72 2.70 0.58 1 2 3 4 5 1.44 1.44 HS.145603 0.08 -0.35 -0.19 2.53 0.23 1 2 3 4 5 1.44 1.44 C10RF168 -0.17 -0.95 1.18 1.93 1.09 1 2 3 4 5 1.44 1.44 HS.577140 0.88 -0.74 -0.29 2.13 0.33 1 2 3 4 5 1.44 1.44 HS.542429 1.25 -1.21 -1.15 1.66 -0.92 1 2 3 4 5 1.43 1.43 LOC647656 1.54 -0.61 2.04 2.26 -1.09 1 2 3 4 5 1.43 1.43 SELV 1.58 0.04 0.20 2.91 -0.34 1 2 3 4 5 1.43 1.43 SCN2A -0.61 0.64 1.62 3.51 0.04 1 2 3 4 5 1.43 1.43 LOC652102 0.41 -0.34 -0.16 2.52 -0.23 1 2 3 4 5 1.43 1.43 HS.564415 -0.80 -0.80 0.92 2.06 -0.34 1 2 3 4 5 1.43 1.43 HS.149883 0.69 -0.43 1.56 2.42 1.79 1 2 3 4 5 1.42 1.42 LOC440268 2.47 -0.18 0.10 2.66 0.31 1 2 3 4 5 1.42 1.42 CHGB 0.64 -1.00 -0.63 1.85 -0.67 1 2 3 4 5 1.42 1.42 TMEFF2 4.55 -1.11 -0.33 1.74 -0.89 1 2 3 4 5 1.42 1.42 HS.74052 0.96 -0.30 0.80 2.53 0.59 1 2 3 4 5 1.42 1.42 LOC729164 0.98 -0.73 -0.04 2.10 -0.22 1 2 3 4 5 1.42 1.42 HS.582502 -0.21 0.28 1.28 3.11 1.93 1 2 3 4 5 1.41 1.41 IRX2 0.55 -0.30 0.73 2.53 -1.08 1 2 3 4 5 1.41 1.41 PALM2 -0.04 -1.57 -0.96 1.25 1.38 1 2 3 4 5 1.41 1.41 ST N4 0.99 0.53 3.34 3.36 -0.94 1 2 3 4 5 1.41 1.41 MIXL1 0.42 -0.11 1.25 2.72 -1.14 1 2 3 4 5 1.41 1.41 HS.561412 -0.37 -0.77 0.47 2.05 -0.79 1 2 3 4 5 1.41 1.41 GLRA2 -0.43 -1.06 1.64 1.76 3.42 1 2 3 4 5 1.41 1.41 LOC255411 -0.18 -0.26 0.01 2.55 -0.02 1 2 3 4 5 1.41 1.41 HS.543890 -0.27 -0.14 -0.11 2.68 -0.46 1 2 3 4 5 1.41 1.41 HS.559928 1.04 -0.58 0.01 2.23 -0.65 1 2 3 4 5 1.41 1.41 HS.442058 -1.63 -0.55 0.62 2.27 -0.84 1 2 3 4 5 1.41 1.41 HS.540427 -0.31 -0.30 -0.16 2.51 0.16 1 2 3 4 5 1.41 1.41 FAM90A11P 0.93 -0.68 1.63 2.13 -0.58 1 2 3 4 5 1.41 1.41 Table 4 192 HS.132048 0.48 -0.49 -0.06 2.32 0.67 1 2 3 4 5 1.40 1.40 NTS 0.46 0.27 2.61 3.08 -0.42 1 2 3 4 5 1.40 1.40 MGC16291 4.47 -0.62 1.38 2.18 3.58 1 2 3 4 5 1.40 1.40 SLC10A5 0.64 -1.57 -0.02 1.23 0.16 1 2 3 4 5 1.40 1.40 C1QTNF5 -1.01 -0.16 1.01 2.64 1.21 1 2 3 4 5 1.40 1.40 HS.131049 -1.11 0.20 0.20 3.00 1.75 1 2 3 4 5 1.40 1.40 LOC646748 0.45 -1.15 -0.16 1.65 0.68 1 2 3 4 5 1.40 1.40 HS.545093 0.71 0.14 0.92 2.93 3.16 1 2 3 4 5 1.40 1.40 HS.570817 1.53 -0.11 0.15 2.68 1.08 1 2 3 4 5 1.39 1.39 HS.559741 -1.00 -0.64 -0.35 2.14 -0.07 1 2 3 4 5 1.39 1.39 DNAH9 -0.51 -0.91 0.02 1.87 -0.42 1 2 3 4 5 1.39 1.39 HS.310643 0.48 -0.50 1.88 2.28 1.97 1 2 3 4 5 1.39 1.39 SOX11 0.08 -1.00 0.88 1.76 0.36 1 2 3 4 5 1.38 1.38 HS.171487 0.47 -0.54 1.04 2.22 0.83 1 2 3 4 5 1.38 1.38 HS.579053 0.54 -0.27 0.47 2.47 1.45 1 2 3 4 5 1.37 1.37 KRTAP5-4 -0.05 -1.35 -0.34 1.40 0.04 1 2 3 4 5 1.37 1.37 HS.48447 0.39 -0.30 1.83 2.44 -0.58 1 2 3 4 5 1.37 1.37 HS.382116 -0.70 -0.55 1.56 2.19 -0.47 1 2 3 4 5 1.37 1.37 LOC647865 -0.47 -1.03 -0.62 1.70 -0.57 1 2 3 4 5 1.37 1.37 HS.197685 -0.08 -0.72 -0.11 2.01 -0.11 1 2 3 4 5 1.37 1.37 SLC22A3 1.64 -0.46 0.15 2.27 -1.29 1 2 3 4 5 1.36 1.36 LRRC52 -1.11 0.03 1.42 2.75 -0.31 1 2 3 4 5 1.36 1.36 HS.176655 -0.77 -1.37 0.37 1.35 0.12 1 2 3 4 5 1.36 1.36 HS.377348 0.14 -0.36 1.37 2.35 -0.34 1 2 3 4 5 1.36 1.36 LOC652439 1.03 -1.18 -0.35 1.52 -0.23 1 2 3 4 5 1.35 1.35 SERPINB13 -1.36 -1.33 -1.25 1.37 1.77 1 2 3 4 5 1.35 1.35 LOC653397 3.12 -0.19 1.19 2.51 -0.35 1 2 3 4 5 1.35 1.35 HS.540072 -0.17 0.78 1.19 3.48 -0.09 1 2 3 4 5 1.35 1.35 GPR148 -0.34 -0.46 0.99 2.24 0.18 1 2 3 4 5 1.35 1.35 LOC644098 -0.59 -0.90 -0.28 1.80 0.63 1 2 3 4 5 1.35 1.35 LOC730419 1.58 -0.53 0.23 2.17 0.79 1 2 3 4 5 1.35 1.35 HS.328801 0.45 -0.27 -0.03 2.43 1.96 1 2 3 4 5 1.35 1.35 LOC650013 -0.29 -0.22 0.43 2.48 0.41 1 2 3 4 5 1.35 1.35 LOC647247 -0.60 -1.36 0.27 1.33 -0.04 1 2 3 4 5 1.35 1.35 LOC644974 1.91 0.06 0.30 2.75 2.47 1 2 3 4 5 1.35 1.35 HS.567023 -0.42 -0.27 1.42 2.42 -0.42 1 2 3 4 5 1.34 1.34 HS.127550 -0.23 0.30 2.60 2.99 1.83 1 2 3 4 5 1.34 1.34 LOC653684 1.74 0.30 0.37 2.98 2.05 1 2 3 4 5 1.34 1.34 KRT39 0.43 -1.24 -0.82 1.44 -1.16 1 2 3 4 5 1.34 1.34 HS.565269 0.12 -0.17 0.38 2.51 -0.17 1 2 3 4 5 1.34 1.34 HS.543999 -0.21 -0.44 -0.15 2.23 0.11 1 2 3 4 5 1.34. 1.34 LOC648851 -0.63 -1.40 -1.24 1.27 -1.26 1 2 3 4 5 1.33 1.33 HS.526491 1.55 0.04 2.09 2.71 0.14 1 2 3 4 5 1.33 1.33 MOBP -0.31 0.26 0.32 2.93 1.67 1 2 3 4 5 1.33 1.33 HS.553409 -0.79 -0.29 0.14 2.38 1.82 1 2 3 4 5 1.33 1.33 CSF1 0.17 -1.16 -0.57 1.50 -0.51 1 2 3 4 5 1.33 1.33 ALDH3B2 0.71 -0.22 0.48 2.44 -0.62 1 2 3 4 5 1.33 1.33 LOC641905 3.20 -1.35 0.53 1.30 0.68 1 2 3 4 5 1.33 1.33 LOC648879 0.49 -0.47 -0.44 2.18 -0.52 1 2 3 4 5 1.32 1.32 Table 4 193 LOC653286 -1.27 -0.38 0.72 2.26 -0.23 1 2 3 4 1.32 1.32 MMP8 -0.61 -1.20 -0.50 1.43 1.84 1 2 3 4 5 1.32 1.32 MS4A13 0.08 -0.35 1.56 2.27 -0.03 1 2 3 4 5 1.31 1.31 C10RF49 -0.39 -0.74 0.23 1.88 -0.21 1 2 3 4 5 1.31 1.31 HS.562812 -0.55 -0.71 0.76 1.91 -0.40 1 2 3 4 5 1.31 1.31 KCNJ4 -0.35 -0.51 -0.25 2.11 -0.37 1 2 3 4 5 ; 1.31 1.31 HS.540065 1.40 -0.17 0.82 2.44 0.46 1 2 3 4 5 1.31 1.31 CSAG2 -1.34 -1.19 -0.11 1.42 0.08 1 2 3 4 5 1.31 1.31 OR13H1 0.51 0.13 0.74 2.74 -1.39 1 2 3 4 5 1.31 1.31 HS.132448 -0.54 0.12 0.14 2.73 0.09 1 2 3 4 5 1.30 1.30 LOC645839 -0.02 -0.92 -0.32 1.68 1.02 1 2 3 4 5 1.30 1.30 HS.540736 2.35 -0.52 1.96 2.08 0.16 1 2 3 4 5 1.30 1.30 C120RF42 3.22 -0.29 -0.14 2.31 -0.84 1 2 3 4 5 1.30 1.30 LRP4 1.24 -0.77 -0.36 1.82 3.02 1 2 3 4 5 1.30 1.30 LOC650517 0.38 -0.28 0.71 2.32 -0.18 1 2 3 4 5 1.30 1.30 HIST1H1E -0.31 0.87 2.44 3.47 -1.13 1 2 3 4 5 1.30 1.30 HS.537646 0.39 0.82 1.66 3.42 1.92 1 2 3 4 5 1.30 1.30 LOC399898 -0.71 -0.10 0.23 2.49 0.62 1 2 3 4 5 1.30 1.30 WFIKKN2 -1.15 -0.86 0.24 1.73 3.16 1 2 3 4 5 1.30 1.30 C30RF52 -0.07 -0.16 -0.03 2.43 0.32 1 2 3 4 5 1.30 1.30 INA -0.91 -0.23 -0.01 2.36 0.26 1 2 3 4 5 1.30 1.30 NAALAD2 -0.44 -0.41 -0.03 2.16 -0.25 1 2 3 4 5 1.28 1.28 LOC642005 3.60 -0.16 1.38 2.41 0.29 1 2 3 4 5 1.28 1.28 C30RF56 -0.17 -0.50 -0.06 2.06 -0.03 1 2 3 4 5 1.28 1.28 HS.443913 1.96 -0.74 0.26 1.82 -0.55 1 2 3 4 5 1.28 1.28 LOC643652 0.43 -0.40 0.48 2.15 0.12 1 2 3 4 5 1.28 1.28 LOC651301 -0.73 -0.63 -0.38 1.92 -0.22 1 2 3 4 5 1.27 1.27 HS.580670 3.04 -0.83 0.63 1.71 0.25 1 2 3 4 5 1.27 1.27 HS.126387 1.70 -1.16 1.28 1.38 -1.75 1 2 3 4 5 1.27 1.27 HS.539586 1.90 -1.42 0.30 1.12 0.50 1 2 3 4 5 1.27 1.27 NEUR0D1 1.48 -0.51 0.81 2.02 1.01 1 2 3 4 5 1.26 1.26 TMEM 16C 0.37 -1.22 -0.12 1.31 1.32 1 2 3 4 5 1.26 1.26 HS.437797 -0.27 -0.63 -0.22 1.89 -0.67 1 2 3 4 5 1.26 1.26 GFRAL 0.01 0.28 0.29 2.81 -0.29 1 2 3 4 5 1.26 1.26 LOC203510 -0.19 -0.29 -0.18 2.23 -0.34 1 2 3 4 5 1.26 1.26 MOV10L1 0.34 -0.17 0.77 2.35 -0.04 1 2 3 4 5 1.26 1.26 CHL1 -0.04 -0.65 -0.55 1.87 0.84 1 2 3 4 5 1.26 1.26 FABP6 -0.48 -1.32 -1.08 1.20 0.03 1 2 3 4 5 1.26 1.26 HS.538409 -0.87 -0.22 -0.06 2.29 0.78 1 2 3 4 5 1.26 1.26 HS.552013 -0.17 -0.12 0.24 2.40 -0.28 1 2 3 4 5 1.26 1.26 HS.12535 1.43 -1.38 0.40 1.13 0.39 1 2 3 4 5 1.26 1.26 HS.545463 1.06 -0.37 0.59 2.14 -0.30 1 2 3 4 5 1.26 1.26 C90RF139 -0.73 -1.64 -0.31 0.87 0.80 1 2 3 4 5 1.26 1.26 NMUR2 -1.11 -1.27 0.36 1.24 0.08 1 2 3 4 5 1.26 1.26 OR6Q1 LOO ; -0.28 1.43 2.23 -1.09 1 2 3 4 5 1.25 1.25 NMS -0.07 -0.49 0.31 2.02 1.36 1 2 3 4 5 1.25 1.25 HS.573028 1.34 -0.67 1.33 1.83 2.72 1 2 3 4 5 1.25 1.25 HS.544279 -1.00 -0.87 0.31 1.63 0.34 1 2 3 4 5 1.25 1.25 LOC643085 1.14 -1.18 -0.06 1.31 -0.44 1 2 3 4 5 1.25 1.25 Table 4 194

KCNMB2 -0.21 -0.41 -0.15 2.08 -0.24 1 2 3 4 5 1.25 1.25 HS.159080 6.41 -0.25 -0.01 2.25 1.83 1 2 3 4 5 1.25 1.25 LOC388419 -0.53 -0.52 0.61 1.97 1.62 1 2 3 4 5 1.25 1.25 LOC642574 -0.21 -0.27 -0.09 2.22 0.34 1 2 3 4 1.24 1.24 HS.199272 0.66 -0.54 -0.09 1.95 0.16 1 2 3 4 5 1.24 1.24 RANBP3L -1.27 -0.56 0.55 1.92 0.56 1 2 3 4 5 1.24 1.24 HS.334146 -0.93 -0.63 -0.45 1.86 0.49 1 2 3 4 5 1.24 1.24 HS.567032 -0.04 -0.21 0.05 2.27 0.78 1 2 3 4 5 1.24 1.24 C210RF69 -0.14 -0.53 -0.25 1.95 0.46 1 2 3 4 5 1.24 1.24 HS.540448 2.37 1.11 1.79 3.59 1.36 1 2 3 4 5 1.24 1.24 ZNF804B 2.25 -0.64 0.08 1.84 0.18 1 2 3 4 5 1.24 1.24 HS.549921 1.30 -0.49 -0.05 1.98 0.20 1 2 3 4 5 1.24 1.24 HS.434238 -0.42 -0.28 1.25 2.20 0.01 1 2 3 4 5 1.24 1.24 MGC39606 -0.76 -1.25 -0.48 1.22 3.13 1 2 3 4 5 1.24 1.24 LOC647448 -0.78 -0.93 -0.37 1.54 0.57 1 2 3 4 5 1.23 1.23 HS.542141 0.01 0.15 0.22 2.62 0.19 1 2 3 4 5 1.23 1.23 C210RF88 -0.07 -0.34 -0.13 2.13 -0.27 1 2 3 4 5 1.23 1.23 KCNQ5 4.20 -0.14 1.53 2.33 3.99 1 2 3 4 5 1.23 1.23 LOC730862 -0.32 0.07 1.62 2.54 0.55 1 2 3 4 5 1.23 1.23 HS.560166 0.28 -0.62 -0.12 1.85 -0.20 1 2 3 4 5 1.23 1.23 HS.575834 1.72 -0.82 0.55 1.64 3.06 1 3 4 5 1.23 1.23 HS.541302 -1.46 -1.39 -0.29 1.07 -0.67 1 2 3 4 5 1.23 1.23 AL2 0.72 -0.74 0.25 1.71 1.05 1 2 3 4 5 1.23 1.23 LOC389422 2.51 0.10 0.26 2.55 0.20 . 1 2 3 4 5 1.23 1.23 OR6N1 -1.28 -0.08 0.05 2.36 -0.95 1 2 3 4 5 1.22 1.22 EFCAB4B -0.16 -0.56 -0.12 1.89 -0.29 1 2 3 4 5 1.22 1.22 ADAMTSL1 1.28 -0.96 -0.60 1.48 -0.16 1 3 4 5 1.22 1.22 LOC643194 -0.22 0.01 1.67 2.44 1.62 1 2 3 4 5 1.22 1.22 HS.425510 -0.44 -0.66 -0.44 1.77 -0.04 1 2 3 4 5 1.22 1.22 KCNE2 -0.42 -0.24 1.90 2.19 -0.35 1 2 3 4 5 1.21 1.21 TMPRSS6 -0.64 -0.97 -0.19 1.46 -0.38 1 2 3 4 5 1.21 1.21 HS.545764 -0.58 -0.90 -0.40 1.52 2.40 1 2 3 4 5 1.21 1.21 TNFRSFllA 0.20 -1.67 -0.88 0.75 0.85 1 2 3 4 5 1.21 1.21 HS.539867 0.38 -0.07 0.79 2.35 0.04 1 2 3 4 5 1.21 1.21 MS4A5 -0.61 -1.11 1.24 1.31 0.47 1 2 3 4 5 1.21 1.21 HS.130155 -0.13 -0.31 -0.02 2.10 0.08 1 2 3 4 5 1.21 1.21 LOC652468 0.62 -0.72 0.86 1.69 2.83 1 2 3 4 5 1.21 1.21 HS.162062 2.25 -0.61 1.05 1.80 0.44 1 2 3 4 5 1.20 1.20 LENEP 0.11 0.14 0.14 2.54 -0.98 1 2 3 4 5 1.20 1.20 HS.244341 0.95 -0.11 0.95 2.29 0.16 1 2 3 4 5 1.20 1.20 TAGLN3 1.37 -0.86 0.61 1.54 -0.55 1 2 3 4 5 1.20 1.20 G6PC2 -0.67 0.11 0.24 2.52 -0.33 1 2 3 4 5 1.20 1.20 HS.568866 -0.68 -0.58 -0.45 1.82 0.35 1 2 3 4 5 1.20 1.20 SERPINA12 0.14 -0.54 0.13 1.85 -0.64 1 2 3 4 5 1.20 1.20 LOC284428 -0.45 -0.36 0.00 2.04 3.50 1 2 3 4 5 1.20 1.20 HS.570630 4.16 0.74 2.26 3.13 0.12 1 2 3 4 5 1.20 1.20 USH3A 1.78 -0.37 0.59 2.03 0.08 1 2 3 4 5 1.20 1.20 SFTPA1 1.50 -0.02 0.67 2.37 -0.20 1 2 3 4 5 1.20 1.20 ATAD3C 1.24 -0.17 -0.14 2.23 0.17 1 2 3 4 5 1.20 1.20 Table 4 195

HS.563808 0.12 -1.28 0.12 1.11 0.08 1 2 3 4 5 1.19 1.19 CASR 1.14 -0.47 -0.07 1.91 0.92 1 2 3 4 5 1.19 1.19 HS.573948 -0.52 -0.58 -0.43 1.81 1.21 1 2 3 4 5 1.19 1.19 SYN3 -0.97 -0.93 -0.11 1.45 0.36 1 2 3 4 5 1.19 1.19 HS.531140 0.53 -0.33 1.00 2.05 -0.06 1 2 3 4 5 1.19 1.19 SLC01B3 1.59 -0.95 0.20 1.43 1.06 1 2 3 4 5 1.19 1.19 OR52N1 -0.52 -0.27 1.07 2.10 -0.48 1 2 3 4 5 1.19 1.19 LOC649858 -0.37 -0.34 0.04 2.04 0.24 1 2 3 4 5 1.19 1.19 PGK2 -0.59 -0.12 1.13 2.25 1.59 1 2 3 4 5 1.18 1.18 LOC644209 0.57 -1.17 -0.89 1.20 -0.74 1 2 3 4 5 1.18 1.18 SLC39A5 -0.67 -0.25 0.37 2.11 -0.19 1 2 3 4 5 1.18 1.18 LOC388965 -0.12 -0.47 0.40 1.89 -0.51 1 2 3 4 5 1.18 1.18 HS.277205 2.47 -0.51 1.22 1.84 3.54 1 2 3 4 5 1.18 1.18 OR52B4 4.09 -0.59 1.25 1.76 -1.59 1 2 3 4 5 1.18 1.18 HS.545388 0.28 -1.59 -0.60 0.76 -1.42 1 2 3 4 5 1.18 1.18 HSD17B2 -0.47 -1.50 -0.59 0.85 2.44 1 2 3 4 5 1.17 1.17 HS.563770 1.26 -0.47 0.28 1.88 3.54 1 2 3 4 5 1.17 1.17 HNRNPCL1 -0.34 -0.29 0.86 2.05 -0.32 1 2 3 4 5 1.17 1.17 CSF3 -0.07 -0.94 0.00 1.40 -0.65 1 2 3 4 5 1.17 1.17 HS.543410 0.71 0.35 1.81 2.68 -0.55 1 2 3 4 5 1.17 1.17 OR2L2 1.07 -0.01 1.69 2.32 0.05 1 2 3 4 5 1.17 1.17 LRRC27 -0.80 -0.76 0.59 1.57 -0.50 1 2 3 4 5 1.17 1.17 MYH8 1.57 -0.48 0.47 1.85 0.17 1 2 3 4 5 1.17 1.17 HS.577797 0.19 -0.83 0.78 1.50 0.09 1 3 4 5 1.16 1.16 LOC206227 0.87 -1.02 -0.83 1.31 0.48 1 2 3 4 5 1.16 1.16 HS.581175 -0.49 -0.82 1.45 1.50 -0.45 1 2 3 4 5 1.16 1.16 MAPK12 -0.16 -0.11 1.68 2.21 0.11 1 2 3 4 5 1.16 1.16 HS.24321 1.34 -0.31 1.96 2.01 -0.40 1 2 3 4 5 1.16 1.16 MGC48628 -0.33 -0.41 0.99 1.90 -0.08 1 2 3 4 5 1.16 1.16 LOC653528 -0.64 -1.16 0.43 1.14 -0.14 1 2 3 4 5 1.15 1.15 LOC643406 0.08 -1.25 -0.50 1.05 -0.75 1 2 3 4 5 1.15 1.15 TSPAN11 -0.74 0.47 0.98 2.77 -0.72 1 2 3 4 5 1.15 1.15 HS.576095 0.69 -0.51 1.00 1.79 -0.10 1 2 3 4 5 1.15 1.15 HS.539393 2.09 -0.23 0.30 2.07 -0.02 1 2 3 4 5 1.15 1.15 HS.565437 0.09 -0.21 0.99 2.09 -0.29 1 2 3 4 5 1.15 1.15 HS.538738 0.53 -0.27 0.52 2.02 3.60 1 2 3 4 5 1.15 1.15 HS.433547 1.21 -0.27 1.27 2.03 -1.05 1 2 3 4 5 1.15 1.15 HS.540518 0.51 0.45 1.36 2.74 -0.55 1 2 3 4 5 1.15 1.15 HS.481369 -0.88 -0.65 0.04 1.65 -0.42 1 2 3 4 5 1.15 1.15 LOC728185 3.63 -1.31 0.14 0.98 2.41 1 2 3 4 5 1.15 1.15 LOC643000 1.58 -0.17 0.14 2.12 1.24 1 2 3 4 5 1.14 1.14 LOC649771 0.07 -0.54 0.75 1.75 1.48 1 2 3 4 5 1.14 1.14 HS.565872 0.77 -2.04 -0.94 0.25 0.04 1 2 3 4 5 1.14 1.14 HS.560015 0.28 -0.83 0.10 1.45 3.57 1 2 3 4 5 1.14 1.14 HS.98744 -0.21 -0.28 0.20 2.00 -0.61 1 2 3 4 5 1.14 1.14 HS.582273 -0.19 -0.35 -0.30 1.93 0.15 1 2 3 4 5 1.14 1.14 INSL6 -0.30 -0.91 0.32 1.37 3.28 1 2 3 4 5 1.14 1.14 LOC646194 -0.17 -1.24 0.21 1.03 0.33 1 2 3 4 5 1.14 1.14 SLC13A4 0.16 0.02 0.68 2.29 -0.19 1 2 3 4 5 1.13 1.13 Table 4 196 LOC400858 0.97 -0.18 1.87 2.09 1.42 1 2 3 4 5 1.13 1.13 LOC400406 -1.26 -0.92 0.97 1.35 0.31 1 2 3 4 5 1.13 1.13 HS.199745 -0.19 -0.50 0.03 1.76 0.25 1 2 3 4 5 1.13 1.13 AKAP5 1.04 -0.22 -0.11 2.04 -0.46 1 2 3 4 5 | 1.13 1.13 LOC402635 1.15 -0.88 -0.66 1.38 -0.03 1 2 3 4 5 ; 1.13 1.13 PKNOX2 -0.15 -0.35 0.04 1.91 0.92 1 2 3 4 5 1.13 1.13 ELN 0.06 -0.13 0.85 2.13 0.43 1 2 3 4 5 1.13 1.13 NGEF 0.55 -0.49 -0.40 1.77 0.07 1 2 3 4 5 1.13 1.13 HS.469608 0.78 -1.40 -0.75 0.86 3.64 1 2 3 4 5 1.13 1.13 HS.145490 4.89 -0.11 0.00 2.15 0.89 1 2 3 4 5 1.13 1.13 LOC654200 -0.01 -1.32 -0.36 0.93 -0.62 1 2 3 4 5 1.13 1.13 HS.543358 -0.43 -0.89 -0.58 1.36 0.01 1 2 3 4 5 1.12 1.12 HS.563695 0.21 -0.30 0.90 1.94 1.42 1 2 3 4 5 1.12 1.12 LOC389722 0.15 -0.38 0.67 1.87 -0.21 1 2 3 4 5 1.12 1.12 SLC19A3 0.73 -0.09 0.24 2.16 -0.33 1 2 3 4 5 1.12 1.12 LOC648674 -0.36 -0.70 0.06 1.55 -0.37 1 2 3 4 5 1.12 1.12 LOC648603 0.48 -0.28 -0.21 1.97 0.94 1 2 3 4 5 1.12 1.12 HS.537394 0.86 -0.54 -0.04 1.70 0.75 1 2 3 4 5 1.12 1.12 HS.562760 -0.08 -0.56 -0.05 1.68 -0.92 1 2 3 4 5 1.12 1.12 CYP2W1 0.70 -0.98 0.10 1.25 3.52 1 2 3 4 5 1.12 1.12 HS.379473 -0.52 -0.53 0.87 1.70 2.92 1 2 3 4 5 1.12 1.12 TMC5 -0.29 -0.56 -0.06 1.67 -0.20 1 2 3 4 5 1.12 1.12 LOC643416 0.45 0.16 1.81 2.39 -0.45 1 2 3 4 5 1.12 1.12 HS.550046 0.19 0.00 0.13 2.23 0.04 1 2 3 4 5 1.11 1.11 HS.135233 -0.45 0.09 0.32 2.32 -0.64 1 2 3 4 5 1.11 1.11 HS.557194 -0.95 -0.62 -0.52 1.60 -1.05 1 2 3 4 5 1.11 1.11 HS.486010 -0.01 -0.05 -0.03 2.17 0.03 1 2 3 4 5 1.11 1.11 HS.561481 0.98 -0.47 -0.31 1.75 -0.34 1 2 3 4 5 1.11 1.11 LOC647540 -0.53 -0.35 1.22 1.87 -0.81 1 2 3 4 5 1.11 1.11 AK7 -0.17 -0.21 0.75 2.00 -0.06 1 2 3 4 5 1.11 1.11 HS.564728 6.58 0.30 0.89 2.51 0.75 1 2 3 4 5 1.11 1.11 ENPEP 0.12 -0.93 0.16 1.29 0.33 1 2 3 4 5 1.11 1.11 HS.561339 0.95 -0.62 0.38 1.59 0.86 1 2 3 4 5 1.11 1.11 TCTN2 -0.51 -0.03 2.18 2.18 -0.87 1 2 3 4 5 1.11 1.11 C17ORF50 -0.22 -0.59 0.19 1.62 -0.39 1 2 3 4 5 1.11 1.11 LOC643248 -0.44 -0.52 0.04 1.69 -0.23 1 2 3 4 5 1.10 1.10 LOC644431 0.25 -1.24 0.26 0.97 3.53 1 2 3 4 5 1.10 1.10 BPIL2 -0.97 -0.37 1.05 1.84 0.00 2 3 4 5 1.10 1.10 HS.537802 2.57 -0.74 0.10 1.47 0.09 1 2 3 4 5 1.10 1.10 LOC402110 -0.29 -0.22 1.27 1.99 0.30 1 2 3 4 5 1.10 1.10 XKR7 1.84 0.16 2.29 2.36 -1.21 1 2 3 4 5 1.10 1.10 LOC731682 0.20 0.89 1.09 3.09 3.62 1 2 3 4 5 1.10 1.10 HS.539479 -0.36 -0.58 -0.28 1.62 1.33 1 2 3 4 5 1.10 1.10 UGT1A10 -0.77 1.15 2.68 3.35 1.41 1 2 3 4 5 1.10 1.10 CYP7A1 -0.33 -0.19 0.46 2.01 0.41 1 2 3 4 5 1.10 1.10 ST18 0.19 -0.54 -0.41 1.66 -1.91 2 3 4 5 1.10 1.10 LOC646512 1.67 -0.21 0.22 1.98 0.04 1 2 3 4 5 1.10 1.10 HS.576694 0.07 -0.55 0.02 1.64 -0.05 1 2 3 4 5 1.10 1.10 HS.216701 -0.96 -1.02 0.62 1.17 1.44 1 2 3 4 5 1.09 1.09 Table 4 197 HS.565520 -1.04 -0.74 1.29 1.45 1.27 1 2 3 4 5 1.09 1.09 HS.115881 -0.43 -0.34 0.15 1.84 0.35 1 2 3 4 5 1.09 1.09 CHST4 -0.41 1.07 2.00 3.24 0.14 1 2 3 4 5 1.09 1.09 CST9L -1.59 0.16 0.41 2.33 0.59 1 2 3 4 5 1.09 1.09 C40RF28 0.26 -1.19 0.13 0.98 2.64 1 2 3 4 5 1.09 1.09 HS.528153 -0.18 -0.13 0.77 2.04 0.25 1 2 3 4 5 1.09 1.09 OR2W1 -0.28 1.66 3.39 3.83 0.22 1 2 3 4 5 1.08 1.08 KCNQ4 1.09 -0.51 0.28 1.65 0.41 1 2 3 4 5 1.08 1.08 HS.541814 -0.45 0.03 0.19 2.19 0.73 1 2 3 4 5 1.08 1.08 HS.582223 -1.02 -1.52 0.23 0.64 0.97 1 2 3 4 5 1.08 1.08 LOC649103 2.58 0.15 1.54 2.31 0.56 1 2 3 4 5 1.08 1.08 TNFRSFllB -0.81 -0.18 0.58 1.97 1.13 1 2 3 4 5 1.08 1.08 HS.576446 -0.49 -0.21 0.89 1.94 0.85 1 2 3 4 5 1.08 1.08 HS.545757 -0.71 -0.19 0.17 1.96 0.66 1 2 3 4 5 1.07 1.07 LOC651829 -0.57 -0.72 1.41 1.43 -0.58 1 2 3 4 5 1.07 1.07 HS.539881 -1.26 -0.71 1.11 1.43 2.53 1 2 3 4 5 1.07 1.07 RIG -0.47 0.19 1.17 2.33 -0.46 1 2 3 4 5 1.07 1.07 KRTAP10-7 0.91 -0.08 0.91 2.06 -0.40 1 2 3 4 5 1.07 1.07 HS.578916 0.16 -0.75 -0.20 1.39 -0.72 1 2 3 4 5 1.07 1.07 HS.578449 0.11 0.79 2.61 2.93 1.66 1 2 3 4 5 1.07 1.07 HS.554603 0.16 -0.22 -0.20 1.93 0.24 1 2 3 4 5 1.07 1.07 IL1F8 3.01 0.13 0.65 2.27 0.17 1 2 3 4 5 1.07 1.07 LOC649583 1.01 0.14 0.79 2.28 -0.30 1 2 3 4 5 1.07 1.07 FU42291 -0.37 -0.52 0.42 1.62 0.12 1 2 3 4 5 1.07 1.07 LOC645992 -1.42 0.02 1.07 2.16 1.12 1 2 3 4 5 1.07 1.07 CFTR -0.44 -0.56 0.23 1.57 -0.03 1 2 3 4 5 1.06 1.06 LOC220594 1.34 0.32 1.20 2.44 1.25 1 2 3 4 5 1.06 1.06 HS.562523 0.05 -0.21 0.24 1.91 0.14 1 2 3 4 5 1.06 1.06 GPR111 -1.74 -1.67 -0.63 0.45 2.15 1 2 3 4 5 1.06 1.06 HS.541315 -0.18 -0.29 -0.06 1.83 0.08 1 2 3 4 5 1.06 1.06 HS.574010 -0.03 -1.15 0.29 0.97 -1.05 1 2 3 4 5 1.06 1.06 HS.539872 -0.26 -0.32 -0.32 1.80 0.14 1 2 3 4 5 1.06 1.06 EFNA5 -0.24 -0.38 0.93 1.74 1.43 1 2 3 4 5 1.06 1.06 HS.562361 -1.00 -0.31 0.34 1.80 0.58 1 2 3 4 5 1.06 1.06 HS.540840 2.06 -0.51 0.00 1.60 0.62 1 2 3 4 5 1.06 1.06 HS.577767 -0.42 -0.63 0.13 1.48 1.14 1 2 3 4 5 1.06 1.06 KCNJ12 1.51 0.74 1.07 2.86 2.57 1 2 3 4 5 1.06 1.06 GPR87 -0.18 -0.32 0.54 1.79 0.74 1 2 3 4 5 1.06 1.06 HS.581442 -0.41 -0.28 0.75 1.83 0.21 1 2 3 4 5 1.05 1.05 LOC643576 -0.75 -0.54 0.59 1.57 0.32 1 2 3 4 5 1.05 1.05 IL17A -0.46 -0.25 0.30 1.85 0.59 1 2 3 4 5 1.05 1.05 HS.539215 2.10 0.29 1.22 2.40 0.03 1 2 3 4 5 1.05 1.05 HS.539649 1.15 -0.12 0.35 1.97 0.46 1 2 3 4 5 1.05 1.05 ENPP6 0.41 -0.50 -0.43 1.59 0.58 1 2 3 4 5 1.05 1.05 FU35894 1.70 -0.70 0.34 1.39 0.94 1 2 3 4 5 ; 1.05 1.05 HS.544538 0.51 0.23 0.82 2.32 0.44 1 2 3 4 1.04 1.04 FGFR3 -0.33 -0.20 0.22 1.89 0.19 1 2 3 4 s 1.04 1.04 HS.171043 -0.03 -0.26 -0.24 1.82 0.27 1 2 3 4 S 1.04 1.04 HS.575985 1.11 1.03 1.09 3.12 1.07 1 2 3 4 5 1.04 1.04 Table 4 198

LG 8 0.79 -0.15 0.40 1.93 0.01 1 2 3 4 . 5 1.04 1.04 HS.581603 -0.28 0.15 1.46 2.23 2.32 1 2 3 4 5 1.04 1.04 LOC650399 -0.87 -1.16 -0.70 0.92 -0.73 1 2 3 4 5 1.04 1.04 HS.384579 -0.08 -0.63 -0.52 1.45 -0.44 1 2 3 4 5 1.04 1.04 HS.434944 -0.82 -0.14 0.53 1.94 1.27 1 2 3 4 5 1.04 1.04 LOC644347 -0.68 -1.53 0.10 0.54 1.98 1 2 3 4 5 ; 1.04 1.04 HS.547625 2.16 0.98 1.91 3.05 -1.11 1 2 3 4 5 1.04 1.04 FGF16 -0.37 -0.21 -0.14 1.86 -1.57 1 2 3 4 5 1.03 1.03 HS.434884 1.62 -0.08 -0.05 1.98 -0.19 1 2 3 4 5 1.03 1.03 CDSN -0.42 0.09 1.42 2.15 -0.44 1 2 3 4 5 1.03 1.03 SLC26A7 4.11 -0.89 -0.76 1.18 0.29 1 2 3 4 5 1.03 1.03 LOC650543 -0.19 -0.59 0.59 1.47 -0.09 1 2 3 4 5 1.03 1.03 HS.538779 -0.33 -0.78 0.06 1.28 0.58 1 2 3 4 5 1.03 1.03 HS.572972 0.33 -0.34 1.45 1.73 -0.70 1 2 3 4 5 1.03 1.03 TSPAN8 -0.22 -0.78 0.69 1.28 -0.60 1 2 3 4 5 1.03 1.03 HS.573566 -0.08 -0.18 0.46 1.88 1.04 1 2 3 4 5 1.03 1.03 HS.544363 1.08 0.41 2.20 2.47 0.57 1 2 3 4 5 1.03 1.03 WNT9B -0.14 -0.77 0.84 1.28 -0.03 1 2 3 4 5 1.03 1.03 PABPC5 -1.26 -0.86 -0.12 1.19 -0.62 1 2 3 4 5 1.03 1.03 HS.539414 0.57 -0.79 0.36 1.27 -0.10 1 2 3 4 5 1.03 1.03 HS.560378 0.15 0.31 0.76 2.36 -0.48 1 2 3 4 5 1.02 1.02 LOC646094 -0.89 -0.55 0.21 1.50 2.53 1 2 3 4 5 1.02 1.02 LOC652127 -0.38 0.46 0.97 2.51 0.44 1 2 3 4 5 1.02 1.02 HS.149058 -0.01 -0.31 0.71 1.73 0.36 1 2 3 4 5 1.02 1.02 PABPC1L2B 1.21 -0.25 0.70 1.79 0.99 1 2 3 4 5 1.02 1.02 CPA2 -1.12 -0.27 1.18 1.77 0.78 1 2 3 4 5 1.02 1.02 HS.137098 1.36 1.27 2.28 3.32 2.03 1 2 3 4 5 1.02 1.02 RHOV -0.09 -0.86 -0.10 1.18 -0.91 1 2 3 4 5 1.02 1.02 HS.559708 0.00 0.05 1.33 2.09 2.76 1 2 3 4 5 1.02 1.02 GSTTPl 1.72 -1.44 -0.17 0.58 2.30 1 2 3 4 5 1.01 1.01 HS.134626 0.26 -0.06 0.56 1.97 0.11 1 2 3 4 5 1.01 1.01 HS.537647 0.39 -0.57 -0.29 1.45 1.23 1 2 3 4 5 1.01 1.01 EDNRA 1.50 0.08 0.26 2.11 1.27 1 2 3 4 5 1.01 1.01 HS.444688 -0.32 -0.62 -0.27 1.39 -0.57 1 2 3 4 5 1.01 1.01 LOC653541 -0.01 0.05 0.23 2.07 0.02 1 2 3 4 5 1.01 1.01 EST -0.16 -0.39 0.84 1.63 0.06 1 2 3 4 5 1.01 1.01 HS.566282 -0.14 -0.32 0.91 1.70 0.96 1 2 3 4 5 1.01 1.01 HS.580556 -0.54 -0.78 0.44 1.22 2.32 1 2 3 4 5 1.00 1.00 CLCN1 -0.36 0.32 1.64 2.33 0.30 1 2 3 4 5 1.00 1.00 HS.565565 0.55 -0.54 0.89 1.46 -0.94 1 2 3 4 5 1.00 1.00 SLC7A2 4.84 -1.60 -0.02 0.40 1.91 1 2 3 4 5 1.00 1.00 HS.436868 0.78 -1.52 -0.29 0.49 0.44 1 2 3 4 5 1.00 1.00 LOC284215 -0.13 -0.73 0.09 1.27 -0.62 1 2 3 4 5 1.00 1.00 HS.578208 -0.35 -0.43 -0.04 1.56 0.00 1 2 3 4 5 1.00 1.00 LOC644573 0.71 1.90 2.18 3.89 -0.40 1 2 3 4 5 1.00 1.00 OTOF 0.14 -0.43 -0.39 1.56 -0.68 1 2 3 4 5 1.00 1.00 Table 4 199 FBX016 0.24 1.65 0.81 -0.34 -0.58 1 2 3 4 5 -1.00 1.00 PRDM16 -1.25 2.45 1.09 0.46 -0.29 1 2 3 4 5 -1.00 1.00 LOC644628 1.18 1.53 -0.25 -0.46 0.25 1 2 3 4 5 -1.00 1.00 PCDH11X 2.79 1.84 0.99 -0.16 2.49 1 2 3 4 5 i -1.00 1.00 LOC651017 1.04 1.89 0.05 -0.11 1.20 1 2 3 4 -1.00 1.00 C110RF76 1.09 2.49 1.56 0.49 1.18 1 2 3 4 5 -1.00 1.00 HS.556368 0.85 1.13 0.21 -0.87 0.36 1 2 3 4 5 : -1.00 1.00 HS.576067 -0.12 2.03 0.22 0.03 -0.10 1 2 3 4 5 -1.00 1.00 OTC -0.59 0.92 -0.41 -1.09 -1.24 1 2 3 4 5 -1.00 1.00 HS.581405 -0.21 1.50 -0.42 -0.50 -0.44 1 2 3 4 5 -1.00 1.00 LOC651128 0.56 1.81 0.57 -0.20 0.50 1 2 3 4 5 -1.00 1.00 CDH13 -1.39 1.05 0.31 -0.96 1.14 1 2 3 4 5 -1.00 1.00 HS.544997 -0.68 0.70 -0.93 -1.31 -0.84 1 2 3 4 5 -1.00 1.00 LOC644371 0.49 1.87 0.66 -0.15 -0.28 1 2 3 4 5 -1.01 1.01 HS.578642 3.14 1.41 1.13 -0.61 -0.63 1 2 3 4 5 -1.01 1.01 VSTM2 -0.35 1.58 -0.11 -0.43 0.22 1 2 3 4 5 -1.01 1.01 HS.576580 -0.27 1.40 -0.29 -0.61 0.04 1 2 3 4 5 -1.01 1.01 HS.563304 0.78 1.84 -0.04 -0.17 -0.03 1 2 3 4 5 -1.01 1.01 HS.119900 1.28 1.85 1.19 -0.17 0.19 1 2 3 4 5 -1.01 1.01 HS.542758 1.08 0.99 -0.65 -1.03 -0.53 1 2 3 4 5 -1.01 1.01 EML5 -0.06 1.77 -0.12 -0.25 -0.08 1 2 3 4 5 -1.01 1.01 HS.548016 0.01 1.45 0.80 -0.58 -0.77 1 2 3 4 5 -1.01 1.01 HS.233221 0.52 1.89 -0.07 -0.13 2.01 1 2 3 4 5 -1.01 1.01 HS.545543 1.87 0.81 -0.98 -1.22 0.86 1 2 3 4 5 -1.01 1.01 KLK15 -0.05 1.23 0.90 -0.81 0.29 1 2 3 4 5 -1.02 1.02 LOC338797 1.31 1.76 -0.08 -0.27 3.14 1 2 3 4 5 -1.02 1.02 FU38723 -0.43 1.52 0.54 -0.51 -0.05 1 2 3 4 5 -1.02 1.02 HS.60764 0.31 1.87 0.48 -0.16 -0.18 1 3 4 5 -1.02 1.02 C16ORF50 0.59 1.03 -0.65 -1.00 -0.84 1 2 3 4 5 -1.02 1.02 XKR9 0.35 1.24 0.46 -0.80 0.34 1 2 3 4 5 -1.02 1.02 TAS2R44 -0.57 1.16 0.28 -0.88 1.40 1 2 3 4 5 -1.02 1.02 TEKT4 -2.28 0.58 -1.38 -1.46 1.40 1 2 3 4 5 -1.02 1.02 TMEM92 1.30 2.06 0.36 0.02 -0.89 1 2 3 4 5 -1.02 1.02 HS.571649 1.46 1.64 0.00 -0.40 -0.84 1 2 3 4 5 -1.02 1.02 LOC645254 -0.55 1.94 0.81 -0.11 1.81 1 2 3 4 5 -1.02 1.02 CACNB2 -0.95 1.85 1.07 -0.20 -0.35 1 2 3 4 5 -1.03 1.03 TMPRSSllB 0.42 2.10 1.50 0.05 0.28 1 2 3 4 5 -1.03 1.03 LOC652715 -0.02 1.23 -0.04 -0.82 -0.83 1 2 3 4 5 -1.03 1.03 TRPV6 -0.69 1.98 0.37 -0.07 0.48 1 2 3 4 5 -1.03 1.03 LOC645745 0.29 2.01 0.58 -0.04 0.06 1 2 3 4 5 -1.03 1.03 HS.575773 0.03 1.87 0.03 -0.18 -0.45 1 2 3 4 5 -1.03 1.03 HS.545728 -0.47 1.54 -0.31 -0.51 -0.40 1 2 3 4 5 -1.03 1.03 HS.561819 -0.36 1.60 1.06 -0.45 -0.13 1 2 3 4 5 -1.03 1.03 TTC9B -0.66 2.33 0.38 0.27 -0.27 1 2 3 4 5 -1.03 1.03 HS.541757 1.94 1.56 0.32 -0.50 -0.58 1 2 3 4 5 -1.03 1.03 HS.566795 0.72 1.39 -0.31 -0.67 0.16 1 2 3 4 5 -1.03 1.03 LOC644196 0.05 1.21 -0.23 -0.85 1.11 1 2 3 4 5 -1.03 1.03 HS.442246 1.99 1.76 0.42 -0.30 -0.03 1 2 3 4 5 -1.03 1.03 LOC644038 0.78 1.93 1.13 -0.13 1.74 1 2 3 4 5 -1.03 1.03 Table 4 200

LOC648846 0.10 1.85 -0.12 -0.21 1.71 1 2 3 4 5 -1.03 1.03 KIR3DX1 -0.16 2.11 0.54 0.04 0.26 1 2 3 4 5 -1.03 1.03 GAL3ST3 1.15 1.99 0.08 -0.08 0.99 1 2 3 4 5 -1.03 1.03 HS.542107 -0.48 1.98 -0.01 -0.09 0.06 1 2 3 4 5 -1.04 1.04 SSX5 0.74 1.51 -0.45 -0.57 2.89 1 2 3 4 5 -1.04 1.04 HS.576872 0.23 2.17 1.89 0.10 0.37 1 2 3 4 5 -1.04 1.04 C90RF53 2.77 1.97 1.76 -0.11 2.30 1 2 3 4 5 -1.04 1.04 KLK9 0.52 0.57 -0.30 -1.51 -0.96 1 2 3 4 5 -1.04 1.04 RHAG 0.62 1.17 -0.41 -0.91 -0.05 1 2 3 4 5 -1.04 1.04 C40RF7 -0.71 1.48 0.00 -0.60 0.18 1 2 3 4 5 -1.04 1.04 HS.132373 0.41 1.40 -0.25 -0.68 -0.38 1 2 3 4 5 -1.04 1.04 HS.551220 1.22 0.92 -0.22 -1.16 -1.37 1 2 3 4 5 -1.04 1.04 HS.550254 -0.37 1.75 -0.14 -0.34 0.27 1 2 3 4 5 -1.04 1.04 LOC647479 1.47 1.45 0.92 -0.64 -0.21 1 2 3 4 5 -1.04 1.04 CBWD2 -0.37 1.40 -0.49 -0.69 -0.52 1 2 3 4 5 -1.05 1.05 IFNE1 1.08 1.68 -0.15 -0.41 -0.45 1 2 3 4 5 -1.05 1.05 HS.364872 0.99 2.21 0.18 0.11 0.21 1 2 3 4 5 -1.05 1.05 CNTN1 -0.99 1.98 -0.09 -0.12 -1.26 1 2 3 4 5 -1.05 1.05 0R1Q1 -0.14 0.54 0.03 -1.56 -1.03 1 2 3 4 5 -1.05 1.05 HS.135835 1.24 1.97 0.96 -0.14 0.74 1 2 3 4 5 -1.05 1.05 HS.582939 -0.07 2.02 -0.01 -0.09 -0.34 1 2 3 4 5 -1.05 1.05 HS.566468 1.21 2.72 1.00 0.61 0.84 1 2 3 4 5 -1.05 1.05 FU45831 -0.82 1.45 1.18 -0.67 -0.04 1 2 3 4 5 -1.06 1.06 HS.573947 1.10 2.64 1.36 0.52 2.79 1 2 3 4 5 -1.06 1.06 HS.541486 1.18 1.62 -0.32 -0.49 1.54 1 2 3 4 5 -1.06 1.06 HS.46473 -0.11 2.21 0.39 0.09 -0.06 1 2 3 4 5 -1.06 1.06 HS.132433 0.95 2.12 1.65 0.00 0.57 1 2 3 4 5 -1.06 1.06 HS.496897 0.83 1.53 0.27 -0.59 -1.06 1 2 3 4 5 -1.06 1.06 LOC653165 2.63 1.71 -0.41 -0.41 0.05 1 2 3 4 5 -1.06 1.06 HS.582599 -1.09 1.29 -0.82 -0.84 -0.12 1 2 3 4 5 -1.06 1.06 HS.500668 1.04 1.63 -0.07 -0.50 0.96 1 2 3 4 5 -1.06 1.06 HS.212688 1.49 1.84 0.88 -0.29 0.25 1 2 3 4 5 -1.06 1.06 LOC644195 4.53 1.47 1.28 -0.65 1.65 1 2 3 4 5 -1.06 1.06 HS.230783 0.29 1.84 1.46 -0.29 2.38 1 2 3 4 5 -1.06 1.06 HS.147320 -0.11 1.78 -0.26 -0.35 1.49 1 2 3 4 5 -1.06 1.06 EPHA3 0.38 1.44 -0.33 -0.69 -0.07 1 2 3 4 5 -1.06 1.06 DKK2 0.64 1.69 -0.06 -0.44 2.65 1 2 3 4 5 -1.06 1.06 GALNTL2 1.74 2.22 0.24 0.09 0.95 1 2 3 4 5 -1.07 1.07 HS.539730 -0.71 1.65 0.72 -0.48 0.29 1 2 3 4 5 -1.07 1.07 HS.148933 -0.24 2.06 0.27 -0.08 0.02 1 2 3 4 5 -1.07 1.07 HS.564280 -1.30 1.95 1.03 -0.18 -0.30 1 2 3 4 5 -1.07 1.07 HS.105423 0.96 1.17 -0.58 -0.97 0.91 1 2 3 4 5 -1.07 1.07 HS.580513 -0.92 1.71 1.32 -0.43 -0.49 1 2 3 4 5 -1.07 1.07 AKR1C1 1.28 0.85 -0.60 -1.29 0.78 1 2 3 4 5 -1.07 1.07 HS.563829 -0.16 2.78 1.47 0.64 -1.41 1 2 3 4 5 -1.07 1.07 LST-3TM12 0.50 1.70 -0.28 -0.45 -0.55 1 2 3 4 5 -1.07 1.07 ZNF639 0.18 2.11 0.82 -0.03 -0.35 1 2 3 4 5 -1.07 1.07 HS.520276 0.50 1.39 0.92 -0.76 0.02 1 2 3 4 5 -1.07 1.07 LOC653244 2.11 1.98 0.14 -0.17 -1.02 1 2 3 4 5 -1.07 1.07

Table 4 202

ADAMTS20 -0.63 0.23 -0.48 -1.99 -0.56 1 2 3 4 5 -1.11 1.11 LOC651315 2.63 0.54 -0.64 -1.68 0.74 1 2 3 4 5 -1.11 1.11 LOC651096 1.75 0.99 0.85 -1.23 -0.58 1 2 3 4 5 -1.11 1.11 HS.561216 0.41 1.22 -0.16 -1.01 -0.30 1 2 3 4 5 -1.11 1.11 HS.583581 -0.05 1.80 1.72 -0.44 0.19 1 2 3 4 5 -1.12 1.12 LOC728219 -0.45 1.58 -0.48 -0.65 0.35 1 2 3 4 5 -1.12 1.12 HS.571336 0.76 1.68 -0.33 -0.55 0.01 1 2 3 4 5 -1.12 1.12 HS.1832 -0.35 1.10 -0.47 -1.14 1.11 1 2 3 4 5 -1.12 1.12 HAS2 1.35 3.03 1.55 0.79 0.85 1 2 3 4 5 -1.12 1.12 HS.561383 -0.29 2.11 -0.05 -0.13 -0.27 1 2 3 4 5 -1.12 1.12 CAPZA3 3.34 4.25 2.50 2.01 3.70 1 2 3 4 5 -1.12 1.12 HS.131229 1.95 1.52 -0.24 -0.72 -0.56 1 2 3 4 5 -1.12 1.12 RNF138P1 4.55 1.47 -0.27 -0.77 0.01 1 2 3 4 5 -1.12 1.12 IYD 1.31 1.33 -0.50 -0.92 0.24 1 2 3 4 5 -1.12 1.12 KCNB2 0.17 1.75 0.56 -0.50 0.50 1 2 3 4 5 -1.12 1.12 HS.539118 -0.07 1.78 0.02 -0.48 -0.59 1 2 3 4 5 -1.13 1.13 HS.355224 -0.33 2.11 1.69 -0.15 0.11 1 2 3 4 5 -1.13 1.13 HS.563438 1.43 2.29 0.11 0.03 1.11 1 2 3 4 5 -1.13 1.13 HS.582980 -1.13 1.19 -0.50 -1.07 0.59 1 2 3 4 5 -1.13 1.13 HS.437410 0.20 2.52 0.41 0.25 0.60 1 2 3 4 5 -1.13 1.13 GRIN2D 2.16 2.53 1.31 0.26 1.85 1 2 3 4 5 -1.14 1.14 HS.539243 -0.07 2.49 0.89 0.22 0.52 1 2 3 4 5 -1.14 1.14 HS.149200 1.87 1.36 -0.51 -0.91 -0.74 1 2 3 4 5 -1.14 1.14 HS.543139 1.14 2.37 0.88 0.10 1.39 1 2 3 4 5 -1.14 1.14 LOC347411 2.57 1.84 0.02 -0.44 -0.42 1 2 3 4 5 -1.14 1.14 HS.519436 -0.45 1.71 0.87 -0.57 -0.61 1 2 3 4 5 -1.14 1.14 HS.544392 -0.39 1.49 -0.15 -0.79 -0.28 1 2 3 4 5 -1.14 1.14 LOC647022 2.19 1.57 0.84 -0.71 -0.46 1 2 3 4 5 -1.14 1.14 ZNF774 -0.41 1.03 -0.74 -1.26 -0.09 1 2 3 4 5 -1.14 1.14 HS.563207 0.29 1.77 0.55 -0.52 -0.17 1 2 3 4 5 -1.14 1.14 HS.439870 0.41 1.86 -0.03 -0.43 0.52 1 2 3 4 5 -1.14 1.14 HS.160849 -0.59 0.63 -0.32 -1.66 0.59 1 2 3 4 5 -1.15 1.15 DOCK4 -1.43 1.41 -0.73 -0.88 1.76 1 2 3 4 5 -1.15 1.15 HS.539934 0.48 2.12 -0.02 -0.18 0.31 1 2 3 4 5 -1.15 1.15 LOC642144 1.38 1.88 -0.29 -0.42 -0.51 1 2 3 4 5 -1.15 1.15 LOC260339 0.12 2.13 0.89 -0.16 -0.14 1 2 3 4 5 -1.15 1.15 HS.577983 -0.50 2.16 0.02 -0.14 0.23 1 2 3 4 5 -1.15 1.15 HS.363303 0.67 2.57 0.76 0.27 -0.72 1 2 3 4 5 -1.15 1.15 LOC646638 -0.01 2.05 0.11 -0.25 0.29 1 2 3 4 5 -1.15 1.15 USH1C 2.17 2.79 0.77 0.49 0.33 1 2 3 4 5 -1.15 1.15 KLKP1 1.10 1.73 0.77 -0.57 -1.32 1 2 3 4 5 -1.15 1.15 SERHL2 -0.14 1.27 0.67 -1.03 -0.87 1 2 3 4 5 -1.15 1.15 HS.539131 0.51 1.91 -0.21 -0.39 -0.54 1 2 3 4 5 -1.15 1.15 LOC649088 1.36 2.20 0.74 -0.10 1.86 1 2 3 4 5 -1.15 1.15 HS.131360 -0.57 2.41 0.89 0.10 0.97 1 2 3 4 5 -1.15 1.15 HS.537639 0.75 1.58 1.07 -0.72 0.98 1 2 3 4 5 -1.15 1.15 HS.543634 0.18 2.22 0.39 -0.08 0.39 1 2 3 4 5 -1.15 1.15 HS.545747 0.23 1.62 -0.23 -0.69 -0.26 1 2 3 4 5 -1.15 1.15 HS.545897 1.35 2.50 1.88 0.18 -0.75 1 2 3 4 5 -1.16 1.16 Table 4 203 HS.561071 -0.17 2.21 0.14 -0.11 0.05 1 2 3 4 5 -1.16 1.16 HS.561730 -0.48 2.32 1.67 0.00 1.19 1 2 3 4 5 -1.16 1.16 SEC11B 0.20 2.68 1.78 0.36 1.08 1 2 3 4 5 ; -1.16 1.16 LOC285735 1.40 2.25 2.08 -0.07 -0.82 1 2 3 4 5 -1.16 1.16 SLC34A3 -0.45 2.63 0.43 0.30 -0.75 1 2 3 4 5 -1.16 1.16 HS.430589 -0.15 2.10 -0.16 -0.22 -0.16 1 2 3 4 5 ; -1.16 1.16 PCDHA12 1.50 2.02 0.98 -0.31 0.40 1 2 3 4 5 -1.16 1.16 HS.121630 -0.70 2.09 1.49 -0.24 1.17 1 2 3 4 5 -1.16 1.16 LOC642718 1.02 1.91 -0.41 -0.42 1.30 1 2 3 4 5 -1.16 1.16 HS.575903 0.52 2.62 0.64 0.29 0.93 1 2 3 4 5 -1.17 1.17 HS.542185 4.87 2.16 0.34 -0.18 0.25 1 2 3 4 5 -1.17 1.17 HS.146719 -1.12 2.75 2.12 0.41 0.57 1 2 3 4 5 -1.17 1.17 PKD2L2 2.73 2.12 0.70 -0.22 0.62 1 2 3 4 5 -1.17 1.17 JPH1 1.81 1.00 -0.20 -1.34 2.00 1 2 3 4 5 -1.17 1.17 HS.566417 0.09 2.16 -0.15 -0.19 -0.07 1 2 3 4 5 -1.17 1.17 HS.555421 -0.08 1.90 0.57 -0.45 2.07 2 3 4 5 -1.17 1.17 HS.553291 -0.14 2.23 -0.09 -0.12 -0.19 1 2 3 4 5 -1.18 1.18 HS.545184 5.63 1.67 -0.13 -0.68 -1.11 1 2 3 4 5 -1.18 1.18 LOC652065 -1.26 1.13 0.26 -1.23 -0.79 1 2 3 4 5 -1.18 1.18 HS.575810 -0.09 2.11 0.06 -0.25 -0.33 1 2 3 4 5 -1.18 1.18 HS.537679 -0.35 2.19 0.02 -0.17 -0.23 1 2 3 4 5 -1.18 1.18 HS.537591 0.45 1.70 -0.39 -0.67 0.53 1 2 3 4 5 -1.18 1.18 OR8H2 -0.12 1.65 1.59 -0.71 0.67 1 2 3 4 5 -1.18 1.18 LOC653514 0.55 1.72 -0.29 -0.65 0.54 1 2 3 4 5 -1.18 1.18 HS.583359 -0.41 2.13 1.03 -0.24 -0.21 1 2 3 4 5 -1.18 1.18 HS.566629 3.84 2.29 0.51 -0.08 0.42 1 2 3 4 5 -1.19 1.19 HS.564212 0.34 1.79 -0.38 -0.58 -0.56 1 2 3 4 5 -1.19 1.19 HS.563971 1.41 1.64 -0.26 -0.73 4.51 1 2 3 4 5 -1.19 1.19 LOC648609 0.85 2.15 0.48 -0.23 -0.35 1 2 3 4 5 -1.19 1.19 FU43505 -0.26 2.16 -0.11 -0.21 0.11 1 2 3 4 5 -1.19 1.19 HS.438023 0.91 1.72 0.89 -0.65 1.05 1 2 3 4 5 -1.19 1.19 HS.246781 0.03 1.46 1.14 -0.92 -0.98 1 2 3 4 5 -1.19 1.19 TFAP2D -0.72 2.63 1.48 0.25 0.67 1 2 3 4 5 -1.19 1.19 HS.129476 -0.33 2.02 1.35 -0.37 2.68 1 2 3 4 5 -1.19 1.19 HS.54773 -0.33 2.06 0.03 -0.32 -0.07 1 . 2 3 4 5 -1.19 1.19 HS.542414 2.25 2.26 0.77 -0.13 1.03 1 2 3 4 5 -1.19 1.19 HS.406568 -0.92 1.19 -0.16 -1.20 -0.46 1 2 3 4 5 -1.19 1.19 LOC388002 0.13 3.40 1.07 1.01 1.72 1 2 3 4 5 : -1.19 1.19 HS.63311 0.14 2.33 0.04 -0.06 0.10 1 2 3 4 5 ; -1.19 1.19 HS.538290 -0.22 1.85 0.76 -0.54 0.59 1 2 3 4 5 -1.20 1.20 HS.578444 0.04 1.76 1.33 -0.64 0.80 1 2 3 4 -1.20 1.20 HS.537695 2.10 2.10 1.83 -0.29 0.66 1 2 3 4 5 -1.20 1.20 HS.211867 0.53 0.37 0.23 -2.02 0.20 1 2 3 4 5 -1.20 1.20 HS.534096 -0.29 1.75 -0.50 -0.65 0.04 1 2 3 4 5 -1.20 1.20 LOC647193 0.10 2.83 0.53 0.44 -0.87 1 2 3 4 5 -1.20 1.20 HS.542879 0.98 1.97 0.06 -0.43 -0.63 1 2 3 4 5 -1.20 1.20 HTR2C 0.22 0.84 0.63 -1.56 1.61 1 2 3 4 5 -1.20 1.20 LOC645781 -0.99 0.99 -1.35 -1.41 -0.55 1 2 3 4 -1.20 1.20 ALDH1L1 2.12 0.43 -0.70 -1.97 -1.50 1 2 3 4 5 -1.20 1.20 Table 4 204

NME5 1.73 1.68 0.05 -0.73 0.92 1 2 3 4 5 -1.20 1.20 T M E 82 -0.25 2.13 -0.10 -0.29 0.00 1 2 3 4 5 -1.21 1.21 LOC732391 0.15 2.31 0.58 -0.10 -0.50 1 2 3 4 5 -1.21 1.21 LOC648775 2.36 1.49 -0.65 -0.92 -0.50 1 2 3 4 5 -1.21 1.21 HS.552332 -0.18 2.53 0.12 0.12 -0.41 1 2 3 4 5 -1.21 1.21 LOC196541 -0.60 1.57 -0.41 -0.85 0.06 1 2 3 4 5 -1.21 1.21 TAS2R48 -0.02 2.54 0.33 0.12 -0.14 1 2 3 4 5 -1.21 1.21 LOC653735 -0.14 1.47 -0.07 -0.95 0.40 1 2 3 4 5 -1.21 1.21 HS.565482 -0.30 2.04 -0.19 -0.38 -0.32 1 2 3 4 5 -1.21 1.21 HS.256249 -1.14 1.58 0.15 -0.85 0.04 1 2 3 4 5 -1.21 1.21 HS.551432 -0.22 2.23 0.91 -0.19 0.12 1 2 3 4 5 -1.21 1.21 LOC646699 -0.38 2.38 0.67 -0.05 1.04 1 2 3 4 5 -1.21 1.21 LOC643467 0.37 2.18 -0.19 -0.25 -0.08 1 2 3 4 5 -1.21 1.21 HS.543923 1.51 2.09 0.04 -0.34 0.93 1 2 3 4 5 -1.21 1.21 OR1E1 -0.66 1.54 -0.33 -0.89 0.85 1 2 3 4 5 -1.21 1.21 CYP1A2 0.21 2.10 0.86 -0.33 0.22 1 2 3 4 5 -1.22 1.22

HS.555388 1.59 2.27 0.48 -0.17 0.32 1 2 3 4 5 , -1.22 1.22 HS.132346 -1.23 2.00 1.05 -0.44 0.56 1 2 3 4 5 -1.22 1.22 MSX1 0.05 0.95 0.16 -1.49 0.46 1 2 3 4 5 -1.22 1.22 LOC652142 -0.34 1.77 0.71 -0.67 0.10 1 2 3 4 5 -1.22 1.22 FLT4 1.03 1.53 -0.02 -0.91 1.63 1 2 3 4 5 -1.22 1.22 MGC4294 1.59 1.90 0.88 -0.55 -0.22 1 2 3 4 5 -1.23 1.23 HS.537609 0.33 2.38 2.03 -0.08 -0.74 1 2 3 4 5 -1.23 1.23 HS.131114 0.52 1.69 0.44 -0.77 2.50 1 2 3 4 5 -1.23 1.23 LOC390595 0.30 3.14 1.37 0.68 0.47 1 2 3 4 5 -1.23 1.23 SNORD108 6.10 2.81 0.55 0.34 0.01 1 2 3 4 5 -1.23 1.23 HS.131038 1.72 1.42 -0.18 -1.05 -0.59 1 2 3 4 5 -1.23 1.23 HS.559605 0.22 1.83 0.44 -0.63 -0.11 1 2 3 4 5 -1.23 1.23 HIST1H2BB -0.60 3.13 2.07 0.66 0.08 1 2 3 4 5 -1.23 1.23 SMR3A -0.08 1.91 -0.51 -0.56 0.65 1 2 3 4 5 -1.24 1.24 HS.540466 2.25 2.14 1.05 -0.33 -0.54 1 2 3 4 5 -1.24 1.24 LOC648262 -0.55 1.61 -0.02 -0.86 0.23 1 2 3 4 5 -1.24 1.24 TDGF1 7.17 1.64 -0.35 -0.84 -0.18 1 2 3 4 5 -1.24 1.24 HS.554217 1.07 1.83 -0.01 -0.65 -0.57 1 2 3 4 5 -1.24 1.24 LRRC55 -0.05 3.18 0.97 0.70 1.29 1 2 3 4 5 -1.24 1.24 KHDRBS2 -0.65 3.58 1.19 1.09 -0.13 1 2 3 4 5 -1.24 1.24 THEM5 -0.42 2.46 1.85 -0.02 3.09 1 2 3 4 5 -1.24 1.24 LOC646456 -0.81 1.15 -0.33 -1.33 -1.41 1 2 3 4 5 -1.24 1.24 RGS8 -0.76 1.33 -0.56 -1.16 -0.80 1 2 3 4 5 -1.25 1.25 COL4A3 0.12 2.34 0.30 -0.15 0.08 1 2 3 4 5 -1.25 1.25 HS.553015 -0.21 2.36 -0.09 -0.14 1.40 1 2 3 4 5 -1.25 1.25 HS.566927 2.64 2.14 -0.25 -0.36 -0.73 1 2 3 4 5 -1.25 1.25 HS.576630 0.32 2.46 0.09 -0.04 0.44 1 2 3 4 5 -1.25 1.25 HS.568324 0.62 1.94 -0.10 -0.56 -0.58 1 2 3 4 5 -1.25 1.25 C120RF25 -0.43 2.33 0.48 -0.18 -0.53 1 2 3 4 5 -1.25 1.25 HS.46879 1.00 2.24 -0.07 -0.27 0.70 1 2 3 4 5 -1.25 1.25 HS.543396 0.05 2.79 0.55 0.29 1.33 1 2 3 4 5 -1.25 1.25 NPPB 0.87 2.55 1.61 0.05 -0.32 1 2 3 4 5 -1.25 1.25 HS.539789 0.18 2.05 0.49 -0.46 -0.03 1 2 3 4 5 -1.25 1.25 Table 4 205 GJD4 1.56 2.10 1.14 -0.41 -0.72 1 2 3 4 5 -1.25 1.25 LOC149224 0.70 2.04 0.45 -0.47 -0.16 1 2 3 4 5 -1.26 1.26 OR52N4 0.19 2.38 0.26 -0.14 -0.26 1 2 3 4 5 -1.26 1.26 HS.542979 0.67 2.24 0.31 -0.28 0.26 1 2 3 4 5 -1.26 1.26 HS.516048 -0.47 2.17 0.41 -0.35 0.67 1 2 3 4 5 -1.26 1.26 SNAI1 -0.84 4.02 1.70 1.50 0.92 1 2 3 4 5 -1.26 1.26 CCDC64 0.49 2.03 0.38 -0.49 0.24 1 2 3 4 5 -1.26 1.26 LOC442382 -0.41 1.61 0.84 -0.91 -0.35 1 2 3 4 5 -1.26 1.26 HS.559427 -0.33 1.10 0.17 -1.42 2.14 1 2 3 4 5 -1.26 1.26 LOC649037 0.53 1.60 0.76 -0.93 1.71 1 2 3 4 5 -1.26 1.26 HS.563252 2.83 1.42 1.31 -1.11 1.58 1 2 3 4 5 -1.26 1.26 HS.213148 0.05 1.43 0.80 -1.11 2.17 1 2 3 4 5 -1.27 1.27 HS.570945 -0.40 1.70 0.61 -0.84 1.02 1 2 3 4 5 -1.27 1.27 HS.540873 -0.36 2.53 0.34 -0.01 0.29 1 2 3 4 5 -1.27 1.27 HS.545117 2.22 3.81 3.19 1.27 1.31 1 2 3 4 5 -1.27 1.27 DOK5 4.32 1.59 0.77 -0.96 3.61 1 2 3 4 5 -1.27 1.27 LOC401164 0.15 2.08 0.12 -0.46 1.96 1 2 3 4 5 -1.27 1.27 HS.552661 -0.15 2.17 0.00 -0.37 0.31 1 2 3 4 5 -1.27 1.27 HS.552741 -0.38 2.23 0.26 -0.32 -0.28 1 2 3 4 5 -1.27 1.27 HS.196469 -0.46 2.26 0.47 -0.30 0.00 1 2 3 4 5 -1.28 1.28 HS.539317 2.58 1.67 0.54 -0.90 -0.31 1 2 3 4 5 -1.29 1.29 HS.147763 0.09 1.74 0.52 -0.83 -0.72 1 2 3 4 5 -1.29 1.29 HS.149828 0.96 2.33 0.68 -0.25 0.24 1 2 3 4 5 -1.29 1.29 HS.343799 -0.35 1.80 0.90 -0.78 1.69 1 2 3 4 5 -1.29 1.29 TRIM55 -1.08 1.27 0.18 -1.31 1.10 1 2 3 4 5 -1.29 1.29 HS.545017 1.18 2.52 0.53 -0.06 0.02 1 2 3 4 5 -1.29 1.29 TAT -0.71 1.85 0.68 -0.74 -0.16 1 2 3 4 5 -1.29 1.29 HS.570866 -0.13 2.15 0.12 -0.44 0.56 1 2 3 4 5 -1.30 1.30 HS.543945 1.30 1.71 0.74 -0.88 0.58 1 2 3 4 5 -1.30 1.30 HS.543346 0.16 2.25 0.32 -0.35 -0.15 1 2 3 4 5 -1.30 1.30 HS.208645 1.08 3.00 1.54 0.40 1.48 1 2 3 4 5 -1.30 1.30 SNCB -0.59 2.39 0.47 -0.21 -0.13 1 2 3 4 5 -1.30 1.30 EPO 0.21 1.81 0.09 -0.80 -0.91 1 2 3 4 5 -1.30 1.30 HS.539286 0.45 2.40 0.55 -0.21 1.28 1 2 3 4 5 -1.31 1.31 LOC120364 -0.20 2.39 -0.14 -0.22 0.35 1 2 3 4 5 -1.31 1.31 LOC643814 1.16 2.45 2.03 -0.16 1.70 1 2 3 4 5 -1.31 1.31 4A3 -0.85 1.92 0.03 -0.69 -0.13 1 2 3 4 5 -1.31 1.31 HS.577994 2.51 1.73 1.20 -0.89 0.08 1 2 3 4 5 -1.31 1.31 HS.538477 1.59 2.41 0.56 -0.21 0.23 1 2 3 4 5 -1.31 1.31 LOC644327 -0.36 2.44 0.25 -0.18 0.04 1 2 3 4 5 -1.31 1.31 LOC650770 3.97 2.19 1.69 -0.43 1.03 1 2 3 4 5 -1.31 1.31 HS. 147007 0.71 4.78 3.31 2.16 0.06 1 2 3 4 5 -1.31 1.31 HS.550967 0.20 1.72 0.16 -0.91 -0.61 1 2 3 4 5 -1.31 1.31 KIAA0738 -0.20 1.74 0.54 -0.89 0.17 1 2 3 4 5 -1.31 1.31 Aug-10 0.58 2.78 1.04 0.15 0.82 1 2 3 4 5 -1.32 1.32 HS.54707 2.39 2.64 0.41 0.01 0.01 1 2 3 4 5 -1.32 1.32 HS.382663 -0.31 2.91 0.69 0.28 -0.52 1 2 3 4 5 -1.32 1.32 LOC651403 -0.86 2.12 0.54 -0.51 -0.73 1 2 3 4 5 -1.32 1.32 M P12 -0.87 0.89 0.12 -1.74 0.99 1 2 3 4 5 -1.32 1.32 Table 4 206

YL4 0.04 2.20 0.15 -0.43 0.43 1 2 3 4 5 -1.32 1.32 RUNDC3A 1.63 3.23 0.69 0.59 -1.03 1 2 3 4 -1.32 1.32 HS.246593 0.17 2.73 2.39 0.09 0.16 1 2 3 4 5 -1.32 1.32 LOC642173 0.51 1.98 0.02 -0.66 -0.44 1 2 3 4 5 -1.32 1.32 HS.575486 -1.82 3.20 0.65 0.56 -0.10 1 2 3 4 5 -1.32 1.32 LOC441617 0.52 2.36 -0.13 -0.28 0.32 1 2 3 4 5 -1.32 1.32 LOC646835 1.29 2.11 1.09 -0.54 0.61 1 2 3 4 5 -1.32 1.32 TCEAL7 2.13 2.23 -0.01 -0.43 -0.47 1 2 3 4 5 -1.33 1.33 HS.156918 1.08 1.73 -0.52 -0.93 1.14 1 2 3 4 5 -1.33 1.33 TTTY20 0.94 2.07 -0.17 -0.58 -0.45 1 2 3 4 5 -1.33 1.33 HS.561405 -0.04 2.55 1.69 -0.11 1.64 1 2 3 4 5 -1.33 1.33 PDE10A 3.77 1.81 0.65 -0.85 0.41 1 2 3 4 5 -1.33 1.33 HS.132725 0.14 2.30 0.10 -0.37 0.14 1 2 3 4 5 -1.33 1.33 LOC649486 0.31 2.31 1.04 -0.36 -0.42 1 2 3 4 5 -1.33 1.33 PSG2 0.61 1.64 -0.22 -1.02 -0.65 1 2 3 4 5 -1.33 1.33 TGM4 -0.93 1.75 1.57 -0.92 -0.72 1 2 3 4 5 -1.33 1.33 HS.582229 -0.42 2.07 -0.49 -0.60 1.87 1 2 3 4 5 -1.34 1.34 LOC645655 -0.25 2.09 -0.10 -0.58 -0.41 1 2 3 4 5 : -1.34 1.34 DGAT2L6 0.82 2.08 -0.42 -0.60 1.05 1 2 3 4 5 -1.34 1.34 HS.562114 -1.30 2.73 0.24 0.04 -0.24 1 2 3 4 5 -1.34 1.34 LOC644320 -0.40 1.48 0.80 -1.20 1.79 1 2 3 4 5 -1.34 1.34 HS.281924 0.29 2.15 -0.47 -0.54 0.62 1 2 3 4 5 -1.34 1.34 HS.574124 6.01 2.25 0.68 -0.44 0.87 1 2 3 4 5 -1.35 1.35 HS.158961 0.30 1.93 -0.53 -0.76 -1.31 1 2 3 4 5 -1.35 1.35 MKX -0.87 0.45 -1.47 -2.24 -1.62 1 2 3 4 5 -1.35 1.35 DRGX 1.07 2.77 0.57 0.08 -0.01 1 2 3 4 5 -1.35 1.35 IMPG1 0.50 3.13 2.39 0.43 2.84 1 2 3 4 5 -1.35 1.35 HS.404330 1.52 1.71 0.35 -1.00 -0.12 1 2 3 4 5 -1.35 1.35 LOC387931 1.07 2.01 0.43 -0.70 0.32 1 2 3 4 5 -1.35 1.35 HS.291993 0.99 2.83 0.98 0.12 -0.47 1 2 3 4 5 -1.35 1.35 HS.546147 0.23 2.32 -0.05 -0.39 -0.44 1 2 3 4 5 -1.35 1.35 LOC649823 1.23 2.87 1.59 0.16 0.16 1 2 3 4 5 -1.36 1.36 APOA4 -0.37 1.90 0.09 -0.82 -0.14 1 2 3 4 5 -1.36 1.36 HS.268250 1.95 2.26 1.17 -0.46 4.37 1 2 3 4 5 -1.36 1.36 HS.541490 0.35 2.38 -0.14 -0.34 -0.25 1 2 3 4 5 -1.36 1.36 BIRC8 1.22 2.54 -0.16 -0.19 -0.12 1 2 3 4 5 -1.36 1.36 LOC653238 1.35 3.49 1.47 0.76 -0.02 1 2 3 4 5 -1.36 1.36 LOC645033 0.55 2.33 -0.36 -0.41 -0.79 1 2 3 4 5 -1.37 1.37 LOC652517 -1.09 2.60 0.12 -0.14 3.69 1 2 3 4 5 -1.37 1.37 HS.582620 -1.15 1.73 0.12 -1.01 1.52 1 2 3 4 5 -1.37 1.37 HIST1H2BI 0.15 4.02 3.05 1.28 1.66 1 2 3 4 5 -1.37 1.37 LOC642383 1.64 3.34 0.83 0.60 0.64 1 2 3 4 5 -1.37 1.37 GH1 -0.10 2.47 1.34 -0.28 0.10 1 2 3 4 5 -1.37 1.37 DKFZP434B06 -0.74 2.45 0.51 -0.29 -0.51 1 2 3 4 5 ; -1.37 1.37 ZNF221 -0.30 2.25 0.29 -0.50 4.22 1 2 3 4 5 : -1.38 1.38 AMELX 1.83 2.43 0.86 -0.33 -0.93 1 2 3 4 5 -1.38 1.38 H5.161998 2.03 3.12 0.67 0.36 -0.41 1 2 3 4 5 -1.38 1.38 HS.544269 0.40 2.43 0.24 -0.33 -0.30 1 2 3 4 5 -1.38 1.38 LIN28 0.19 2.18 0.79 -0.59 -0.03 1 2 3 4 5 -1.38 1.38 Table 4 207 LOC649784 0.61 1.78 -0.79 -0.99 -0.58 1 2 3 4 5 -1.39 1.39 PRY -0.71 1.70 0.08 -1.07 -0.08 1 2 3 4 5 -1.39 1.39 0R2B11 1.38 3.04 1.02 0.26 1.34 1 2 3 4 5 -1.39 1.39 LOC728103 -0.94 1.37 -0.41 -1.41 -0.01 1 2 3 4 -1.39 1.39 HS.545542 -0.81 1.45 -1.01 -1.35 -0.96 1 2 3 4 5 -1.40 1.40 FRMPD2 0.25 2.93 0.36 0.14 0.61 1 2 3 4 5 -1.40 1.40 ELF5 2.59 3.22 1.20 0.41 0.27 1 2 3 4 5 -1.40 1.40 HS.389223 0.05 1.91 0.17 -0.90 0.21 1 2 3 4 5 -1.40 1.40 HS.565752 6.99 0.48 -1.24 -2.32 -2.49 1 2 3 4 5 -1.40 1.40 HS.540832 -1.13 1.53 1.41 -1.28 -0.54 1 2 3 4 5 -1.40 1.40 HS.563387 0.17 2.42 0.00 -0.39 -0.27 1 2 3 4 5 -1.40 1.40 CEACAM6 -0.62 2.15 0.64 -0.66 -0.24 1 2 3 4 5 -1.40 1.40 HS.151274 0.31 1.97 -0.74 -0.84 0.73 1 2 3 4 5 -1.41 1.41 HS.561492 0.21 2.15 1.16 -0.66 -0.74 1 2 3 4 5 -1.41 1.41 AADAC -0.51 2.08 0.53 -0.74 -0.38 1 2 3 4 5 -1.41 1.41 HS.571821 -1.06 2.56 2.07 -0.27 -0.45 1 2 3 4 5 -1.41 1.41 HS.573982 -0.21 2.30 0.20 -0.52 2.02 1 2 3 4 5 -1.41 1.41 LOC647034 1.36 2.05 0.24 -0.78 -0.65 1 2 3 4 5 -1.42 1.42 KRTAP5-10 0.86 2.14 -0.26 -0.69 0.00 1 2 3 4 5 -1.42 1.42 C110RF52 1.21 2.54 0.07 -0.30 -0.85 1 2 3 4 5 -1.42 1.42 HS.562370 0.83 2.23 1.60 -0.61 0.68 1 2 3 4 5 -1.42 1.42 HS.566210 0.15 1.90 -0.68 -0.96 -0.91 1 2 3 4 5 -1.43 1.43 HS.578112 -0.90 1.89 -0.68 -0.97 0.32 1 2 3 4 5 -1.43 1.43 VTN 0.99 0.94 -1.07 -1.93 2.93 1 2 3 4 5 -1.44 1.44 HS.86046 0.56 1.65 0.41 -1.23 -0.20 1 2 3 4 5 -1.44 1.44 HS.562302 -0.96 2.51 1.23 -0.37 0.43 1 2 3 4 5 -1.44 1.44 HS.545267 0.32 2.50 -0.24 -0.38 -0.35 1 2 3 4 5 -1.44 1.44 FU22447 0.14 2.47 0.92 -0.42 2.05 1 2 3 4 5 -1.44 1.44 HS.583052 1.80 1.99 0.37 -0.89 -1.06 1 2 3 4 5 -1.44 1.44 HS.540808 1.54 2.49 0.62 -0.39 0.22 1 2 3 4 5 -1.44 1.44 HS.553119 0.15 3.86 1.49 0.96 -0.25 2 3 4 5 -1.45 1.45 HS.534476 1.74 3.16 0.93 0.26 -0.26 1 2 3 4 5 -1.45 1.45 LOC400793 -0.27 2.45 0.75 -0.45 -0.62 1 2 3 4 5 -1.45 1.45 HS.570848 0.38 2.89 0.33 -0.01 1.84 1 2 3 4 5 -1.45 1.45 OR4C15 -0.42 2.63 0.09 -0.28 0.04 1 2 3 4 5 -1.45 1.45 FGF22 0.16 1.80 -0.75 -1.11 0.65 1 2 3 4 5 -1.46 1.46 HS.541431 -0.63 2.37 -0.41 -0.54 -0.33 1 2 3 4 5 -1.46 1.46 NKX6-2 0.18 2.53 0.26 -0.38 -0.23 1 2 3 4 5 -1.46 1.46 LOC650887 0.08 3.12 0.80 0.20 0.86 1 2 3 4 5 -1.46 1.46 HS.130914 -0.28 2.25 -0.44 -0.68 0.57 1 2 3 4 5 -1.46 1.46 HS.196849 0.54 2.04 -0.83 -0.90 -0.61 1 2 3 4 5 -1.47 1.47 LOC642558 -0.65 3.25 0.59 0.31 2.18 1 2 3 4 5 -1.47 1.47 LOC653920 -1.08 1.78 -0.66 -1.17 2.43 1 2 3 4 5 -1.48 1.48 LOC643993 1.78 3.47 0.56 0.51 -0.41 1 2 3 4 5 -1.48 1.48 LOC641999 -1.41 2.26 1.91 -0.70 2.98 1 2 3 4 5 -1.48 1.48 LOC653169 1.66 2.73 -0.12 -0.23 1.29 1 2 3 4 5 -1.48 1.48 ATP2C2 -0.49 3.48 1.72 0.52 1.01 1 2 3 4 5 -1.48 1.48 TCEAL6 2.47 3.97 2.42 1.01 -0.12 1 2 3 4 5 -1.48 1.48 LOC644151 0.00 3.20 0.55 0.24 0.05 1 2 3 4 5 -1.48 1.48 Table 4 208 HS.567137 0.52 1.53 -0.68 -1.43 0.73 1 2 3 4 5 ; -1.48 1.48 PIH1D2 3.29 1.14 0.03 -1.83 1.88 1 2 3 4 5 : -1.48 1.48 LOC646799 0.38 2.39 1.73 -0.59 2.83 1 2 3 4 5 -1.49 1.49 LOC648763 1.09 2.60 0.57 -0.38 0.26 1 2 3 4 5 -1.49 1.49 HS.537829 -0.47 3.23 0.77 0.25 0.50 1 2 3 4 5 -1.49 1.49 BEAN 3.93 2.36 -0.43 -0.62 0.48 1 2 3 4 5 -1.49 1.49 HS.370108 -0.95 1.54 0.86 -1.44 0.60 1 2 3 4 5 -1.49 1.49 LOC647417 0.24 2.98 0.10 0.00 0.24 1 2 3 4 5 -1.49 1.49 HS.436418 2.00 2.42 1.51 -0.58 1.63 1 2 3 4 5 -1.50 1.50 HS.539795 1.05 3.09 1.14 0.09 1.53 1 2 3 4 5 -1.50 1.50 HS.158672 1.52 2.81 -0.13 -0.19 0.40 1 2 3 4 5 -1.50 1.50 LOC642731 -0.10 2.25 1.10 -0.75 0.32 1 2 3 4 5 -1.50 1.50 HS.438220 0.56 2.27 1.72 -0.75 0.78 1 2 3 4 5 -1.51 1.51 HS.562571 -0.96 2.20 0.56 -0.81 0.34 1 2 3 4 5 -1.51 1.51 HS.196011 0.48 1.83 -0.35 -1.19 0.88 1 2 3 4 5 -1.51 1.51 HS.562122 2.04 2.75 0.25 -0.28 0.41 1 2 3 4 5 -1.52 1.52 HS.570981 -0.07 2.77 0.32 -0.27 0.29 1 2 3 4 5 -1.52 1.52 HS.53997 0.16 2.48 1.62 -0.56 0.54 1 2 3 4 5 -1.52 1.52 IQCD -0.03 1.71 -0.71 -1.33 3.20 1 2 3 4 5 -1.52 1.52 NXF2B -0.26 2.60 0.82 -0.45 -0.41 1 2 3 4 5 -1.52 1.52 HS.159454 -0.58 1.42 -0.01 -1.64 0.43 1 2 3 4 5 -1.53 1.53 LOC653547 -0.28 2.49 0.20 -0.57 0.26 1 2 3 4 5 -1.53 1.53 HS.47878 0.86 2.77 0.01 -0.29 0.07 1 2 3 4 5 -1.53 1.53 PLCH1 -0.20 2.60 0.09 -0.46 -0.40 1 2 3 4 5 -1.53 1.53 HS.560943 0.71 1.53 1.32 -1.55 -0.41 1 2 3 4 -1.54 1.54 PDZK3 -0.26 2.85 0.55 -0.24 -0.07 1 2 3 4 5 -1.54 1.54 HS.559868 1.63 2.34 1.59 -0.74 -1.42 1 2 3 4 5 -1.54 1.54 HS.162010 0.99 2.47 0.07 -0.62 0.47 1 2 3 4 5 -1.54 1.54 HS.573805 1.25 2.44 1.14 -0.65 -0.14 1 2 3 4 5 -1.55 1.55 HS.127366 0.04 2.19 -0.52 -0.91 -0.33 1 2 3 4 5 -1.55 1.55 CNTN2 0.42 3.35 1.60 0.25 0.82 1 2 3 4 5 -1.55 1.55 SNORD26 -0.10 2.12 0.61 -0.98 0.47 1 2 3 4 5 -1.55 1.55 HS.371300 0.08 2.81 0.76 -0.29 0.45 1 2 3 4 5 -1.55 1.55 LOC647836 -0.58 2.25 0.00 -0.85 0.29 1 2 3 4 5 -1.55 1.55 HS.568789 0.14 1.73 -0.57 -1.38 1.74 2 3 4 5 -1.55 1.55 HS.555566 1.14 1.39 -1.04 -1.72 -0.52 1 2 3 4 5 -1.56 1.56 LOC652383 0.41 1.88 -0.28 -1.24 0.24 1 2 3 4 5 -1.56 1.56 HS.97457 0.61 1.87 -0.47 -1.25 1.23 1 2 3 4 5 -1.56 1.56 HS.544249 -0.22 2.60 -0.44 -0.52 -0.13 1 2 3 4 5 -1.56 1.56 ADCY5 0.56 1.87 -0.09 -1.26 3.45 1 2 3 4 5 -1.56 1.56 HS.135735 -0.09 2.33 -0.52 -0.80 0.01 1 2 3 4 5 -1.56 1.56 HS.559957 -0.05 3.40 0.28 0.27 -0.93 1 2 3 4 5 -1.56 1.56 HS.577416 0.26 2.84 0.26 -0.29 -0.08 1 2 3 4 5 -1.57 1.57 MGC40574 0.00 3.03 2.89 -0.10 0.24 1 2 3 4 5 -1.57 1.57 HS.570993 0.36 2.39 0.96 -0.75 -0.52 1 2 3 4 5 -1.57 1.57 HS.575141 1.03 2.64 0.74 -0.51 4.39 1 2 3 4 5 -1.57 1.57 ZPBP -0.86 2.64 -0.19 -0.51 1.04 1 2 3 4 5 -1.57 1.57 LOC642629 2.00 3.33 2.10 0.17 2.98 1 2 3 4 5 -1.58 1.58 SFRP1 0.94 2.80 0.00 -0.35 -0.75 1 2 3 4 5 -1.58 1.58 Table 4 209

SIX2 -1.39 2.13 1.24 -1.02 -0.51 1 2 3 4 5 -1.58 1.58 LOC389151 1.50 2.07 -0.84 -1.09 1.98 1 2 3 4 5 -1.58 1.58 ELMOD1 -0.42 3.27 0.16 0.10 0.34 1 2 3 4 5 -1.58 1.58 LOC644402 -0.44 2.81 -0.23 -0.35 0.21 1 2 3 4 5 -1.58 1.58 HS.577002 -0.53 3.03 0.77 -0.14 -0.11 1 2 3 4 5 -1.58 1.58 HS.580972 2.42 2.53 0.56 -0.64 0.77 1 2 3 4 5 -1.58 1.58 HS.259304 -0.43 3.24 0.57 0.07 0.09 1 2 3 4 5 -1.58 1.58 HS.544409 -0.09 3.20 1.27 0.03 3.04 1 2 3 4 5 -1.59 1.59 ZIC5 0.28 3.08 0.08 -0.11 -0.02 1 2 3 4 5 -1.59 1.59 LOC642660 0.09 3.18 2.18 -0.01 -0.70 1 2 3 4 5 -1.60 1.60 HS.447853 -0.24 2.33 0.66 -0.86 1.43 1 2 3 4 5 -1.60 1.60 OR2T35 -0.68 2.39 -0.77 -0.81 0.01 1 2 3 4 5 -1.60 1.60 HS.575043 -0.12 2.84 2.64 -0.36 -0.74 1 2 3 4 5 -1.60 1.60 HS.566356 1.37 3.57 0.42 0.36 0.33 1 2 3 4 5 -1.60 1.60 RRH -1.11 2.61 0.77 -0.60 0.70 1 2 3 4 5 -1.61 1.61 HS.98394 0.52 3.59 0.54 0.38 . 1.54 1 2 3 4 5 -1.61 1.61 H2BFXP -0.13 1.84 0.61 -1.38 0.82 1 2 3 4 5 -1.61 1.61 LOC390530 0.90 2.88 0.98 -0.35 2.61 1 2 3 4 5 -1.61 1.61 DRP2 -0.27 2.54 1.91 -0.69 -0.06 1 2 3 4 5 -1.61 1.61 HS.278560 -0.12 2.90 -0.16 -0.33 1.49 1 2 3 4 5 -1.61 1.61 HS.333528 -0.84 2.22 -0.26 -1.03 -1.00 1 2 3 4 5 -1.62 1.62 HS.390766 -0.15 2.33 -0.60 -0.92 0.74 1 2 3 4 5 -1.63 1.63 HS.554237 -0.09 2.38 -0.38 -0.87 0.20 1 2 3 4 5 -1.63 1.63 DEFB126 -0.67 3.18 0.18 -0.09 1.54 1 2 3 4 5 -1.64 1.64 LOC642587 0.64 2.03 -0.69 -1.25 1.23 1 2 3 4 5 -1.64 1.64 HS.540116 -0.12 2.86 0.52 -0.42 -0.39 1 2 3 4 5 -1.64 1.64 FRS2 0.10 2.94 -0.20 -0.34 -0.31 1 2 3 4 5 -1.64 1.64 HS.27094 0.70 2.85 0.80 -0.44 -0.15 1 2 3 4 5 -1.64 1.64 HS.566023 -0.51 3.51 0.92 0.22 -0.22 1 2 3 4 5 -1.64 1.64 HS.545141 2.02 2.84 -0.08 -0.45 2.02 1 2 3 4 5 -1.65 1.65 LOC649179 0.52 3.44 0.32 0.14 0.48 1 2 3 4 5 -1.65 1.65 HS.570821 0.75 3.39 0.27 0.08 1.74 1 2 3 4 5 -1.66 1.66 IFNB1 0.18 2.79 0.02 -0.52 2.61 1 2 3 4 5 -1.66 1.66 HS.150688 1.98 2.02 0.29 -1.30 0.08 1 2 3 4 5 -1.66 1.66 LOC650733 1.32 3.12 1.52 -0.20 -0.49 1 2 3 4 5 -1.66 1.66 HS.542152 4.91 2.71 0.44 -0.61 1.36 1 2 3 4 5 -1.66 1.66 HS.565119 1.82 3.10 0.22 -0.24 -0.52 1 2 3 4 5 -1.67 1.67 HS.562527 1.23 3.06 1.53 -0.29 0.79 1 2 3 4 5 -1.67 1.67 HS.447655 0.84 3.19 -0.04 -0.16 -0.35 1 2 3 4 5 -1.68 1.68 HS.541003 0.18 3.55 1.18 0.19 -0.37 1 2 3 4 5 -1.68 1.68 HS.581323 -0.30 3.40 1.13 0.05 0.10 1 2 3 4 5 -1.68 1.68 HS.525926 -0.15 3.14 0.21 -0.22 -0.06 1 2 3 4 -1.68 1.68 FAM154B -0.72 2.96 1.39 -0.41 -1.20 1 2 3 4 5 -1.68 1.68 HS.557985 -0.29 3.06 1.12 -0.31 0.78 1 2 3 4 5 -1.69 1.69 HS.128108 -0.15 3.00 0.01 -0.37 0.96 1 2 3 . 4 5 -1.69 1.69 HS.576163 -0.49 2.54 0.74 -0.84 1.93 1 2 3 4 5 -1.69 1.69 GDF2 -0.05 2.35 -0.88 -1.04 -0.95 1 2 3 4 5 -1.69 1.69 HS.509165 -0.30 2.92 -0.18 -0.46 0.42 . 1 2 3 4 5 -1.69 1.69 HS.542469 -0.54 3.36 0.13 -0.03 -0.13 1 2 3 4 5 -1.69 1.69 Table 4 210 LOC643943 4.18 2.17 -0.56 -1.22 -0.25 1 2 3 4 5 -1.70 1.70 LOC649921 0.29 2.64 0.80 -0.75 -0.82 1 2 3 4 5 -1.70 1.70 OGN -1.05 1.72 -0.59 -1.68 -1.36 1 2 3 4 5 -1.70 1.70 HS.543744 0.00 3.00 1.71 -0.41 1.57 1 2 3 4 5 -1.70 1.70 HS.298335 0.96 2.69 0.39 -0.72 0.18 1 2 3 4 5 -1.71 1.71 LOC645971 5.35 3.09 0.76 -0.33 -0.51 1 2 3 4 5 -1.71 1.71 HS.537809 -0.30 2.96 0.12 -0.47 -0.51 1 2 3 4 5 -1.71 1.71 HS.559777 0.81 2.60 -0.82 -0.84 6.02 1 2 3 4 5 -1.72 1.72 HS.263832 1.32 2.10 1.78 -1.33 0.06 1 2 3 4 5 -1.72 1.72 LOC10010112 0.12 3.02 -0.27 -0.42 1.34 1 2 3 4 5 -1.72 1.72 OR6C65 -0.57 3.04 0.31 -0.41 0.28 1 2 3 4 5 -1.73 1.73 SLC6A19 -0.86 3.06 0.30 -0.40 -0.36 1 2 3 4 5 -1.73 1.73 HS.582384 -0.50 2.84 0.02 -0.63 0.56 1 2 3 4 5 -1.74 1.74 LOC440059 1.19 2.97 0.22 -0.50 0.48 1 2 3 4 5 -1.74 1.74 HS.566675 -0.96 2.84 1.65 -0.64 0.81 1 2 3 4 5 -1.74 1.74 CCDC13 0.66 2.81 -0.07 -0.68 0.33 1 2 3 4 5 -1.74 1.74 CACNG2 -0.65 2.51 0.10 -0.98 1.44 1 2 3 4 5 -1.74 1.74 FAM155A -1.26 3.16 0.20 -0.32 0.16 1 2 3 4 5 -1.74 1.74 LOC642904 0.82 3.09 -0.07 -0.40 1.15 1 2 3 4 5 -1.75 1.75 C20ORF185 -0.89 3.12 2.21 -0.37 0.44 1 2 3 4 5 -1.75 1.75 HS.539798 0.43 2.67 -0.50 -0.82 -0.35 1 2 3 4 5 -1.75 1.75 LOC255187 -0.81 2.85 -0.44 -0.67 -0.45 1 2 3 4 5 -1.76 1.76 FU33706 0.45 3.02 0.22 -0.50 1.07 1 2 3 4 5 -1.76 1.76 LOC645004 4.04 4.98 2.09 1.45 0.40 1 2 3 4 5 -1.77 1.77 CXCL12 0.35 3.81 0.70 0.27 -0.09 1 2 3 4 5 -1.77 1.77 HS.376067 0.20 2.25 -0.07 -1.29 0.91 1 2 3 4 5 -1.77 1.77 HS.559406 1.64 2.36 -0.12 -1.18 0.71 1 2 3 4 5 -1.77 1.77 FU41821 1.52 3.52 0.07 -0.02 2.11 1 2 3 4 5 -1.77 1.77 HS.535454 0.00 3.35 0.77 -0.19 0.31 1 2 3 4 5 -1.77 1.77 HS.207546 -0.12 3.07 0.49 -0.48 1.05 1 2 3 4 5 -1.78 1.78 LOC387693 1.58 2.82 -0.69 -0.74 0.53 1 2 3 4 5 -1.78 1.78 PDE1A 2.80 3.18 2.26 -0.38 1.33 1 2 3 4 5 -1.78 1.78 LOC651872 -0.33 3.35 -0.08 -0.21 0.31 1 2 3 4 5 -1.78 1.78 HS.566569 0.48 3.56 0.12 -0.02 3.11 1 2 3 4 5 -1.79 1.79 GSTM5 -0.24 3.19 -0.33 -0.39 -0.33 1 2 3 4 5 -1.79 1.79 HS.435748 5.98 2.56 1.72 -1.02 -0.05 1 2 3 4 5 -1.79 1.79 HS.297628 0.54 2.66 -0.52 -0.93 0.46 1 2 3 4 5 -1.80 1.80 TTTY21 0.76 2.99 -0.08 -0.61 -0.36 1 2 3 4 5 -1.80 1.80 HS.567081 1.40 3.19 1.73 -0.41 -0.48 1 2 3 4 5 -1.80 1.80 HS.554550 -0.17 3.25 -0.23 -0.36 0.75 1 2 3 4 5 -1.80 1.80 HS.545402 -0.71 3.75 1.22 0.14 2.35 1 2 3 4 5 -1.80 1.80 OR9G1 1.55 2.95 2.09 -0.67 0.49 1 2 3 4 5 -1.81 1.81 HS.469510 1.03 2.53 0.75 -1.09 -0.08 1 2 3 4 5 -1.81 1.81 TBC1D29 -0.91 2.91 0.27 -0.72 0.27 1 2 3 4 5 -1.81 1,81 HS. 544444 1.46 3.09 -0.48 -0.54 0.42 1 2 3 4 5 -1.81 1.81 RP1 -0.17 3.04 0.26 -0.60 -0.75 1 2 3 4 5 -1.82 1.82 HS.566194 0.50 2.85 0.46 -0.79 0.39 1 2 3 4 5 -1.82 1.82 HS.584074 2.22 4.56 2.35 0.92 -0.40 1 2 3 4 5 -1.82 1.82 DEFB114 -1.58 1.65 0.92 -1.99 2.41 1 2 3 4 5 -1.82 1.82 Table 4 211 HS.434904 -0.45 2.65 0.71 -1.00 0.24 1 2 3 4 5 -1.82 1.82 LOC646119 1.14 1.81 -1.44 -1.84 0.52 1 2 3 4 5 -1.82 1.82 HS.539605 1.76 3.43 0.70 -0.22 0.39 1 2 3 4 5 -1.83 1.83 HS.551390 -0.70 : 2.47 0.82 -1.19 0.88 1 2 3 4 5 -1.83 1.83 LOC651730 2.31 2.42 -0.89 -1.24 0.75 1 2 . 3 4 5 -1.83 1.83 HS.542190 1.45 2.37 -0.89 -1.29 0.13 1 2 3 4 5 -1.83 1.83 AB1C 1.35 3.14 0.31 -0.52 0.57 1 2 3 4 5 -1.83 1.83 DEFB127 2.17 2.54 -0.72 -1.13 0.66 1 2 3 4 5 -1.83 1.83 TTC6 1.15; 4.50 1.92 0.83 2.21 1 2 3 4 5 -1.84 1.84 HS.154607 4.77 3.31 3.19 -0.38 -0.61 1 2 3 4 5 -1.84 1.84 EFCBP1 0.97 2.09 1.13 -1.59 -0.03 1 2 3 4 5 -1.84 1.84 HS.578805 0.65 3.31 1.96 -0.38 -0.36 1 2 3 4 5 -1.85 1.85 LOC169834 -0.17 3.09 -0.02 -0.60 -0.20 1 2 3 4 5 -1.85 1.85 HS.580597 2.01 3.42 -0.12 -0.28 0.20 1 2 3 4 5 -1.85 1.85 LOC648680 4.94 3.15 1.80 -0.56 -0.34 1 2 3 4 5 -1.85 1.85 LOC644429 -0.53 3.33 -0.02 -0.39 0.33 1 2 3 4 5 -1.86 1.86 HS.566104 0.05 2.52 1.27 -1.21 1.09 1 2 3 4 5 -1.87 1.87 HS.266041 -0.27 2.51 1.36 -1.22 -0.68 1 2 3 4 5 -1.87 1.87 POU4F2 -0.80 3.43 0.11 -0.32 0.52 1 2 3 4 5 -1.87 1.87 HS.565345 -1.38 2.61 -1.08 -1.14 -0.49 1 2 3 4 5 -1.87 1.87 ZNF180 -0.30 2.14 0.08 -1.61 -1.48 1 2 3 4 5 -1.87 1.87 ACE 0.39 3.12 -0.04 -0.63 -0.20 1 2 3 4 5 -1.88 1.88 LOC643435 -0.59 3.07 0.59 -0.69 -0.10 1 2 3 4 5 -1.88 1.88 HS.538167 -0.53 3.24 0.84 -0.52 0.80 1 2 3 4 5 -1.88 1.88 HS.571032 1.21 3.27 1.21 -0.49 -0.17 1 2 3 4 5 -1.88 1.88 DEFB129 3.46 2.31 1.01 -1.46 4.28 1 2 3 4 5 -1.88 1.88 LOC286239 -0.45 2.25 -0.87 -1.53 -0.92 1 2 3 4 5 -1.89 1.89 LOC340602 0.71 3.30 0.16 -0.49 -0.12 1 2 3 4 5 -1.89 1.89 KIAA1772 0.43 3.09 0.87 -0.73 -0.33 1 2 3 4 5 -1.91 1.91 LOC652246 1.25 3.17 0.01 -0.66 -0.55 1 2 3 4 5 -1.91 1.91 HS.104733 -0.42 3.46 -0.26 -0.37 -0.16 1 2 3 4 5 -1.91 1.91 HS.551291 -1.25 2.80 0.58 -1.03 -1.45 1 2 3 4 5 -1.92 1.92 LOC388259 1.82 2.97 -0.21 -0.87 -0.27 1 2 3 4 5 -1.92 1.92 HS.539250 -0.68 3.30 -0.01 -0.56 0.20 1 2 3 4 5 -1.93 1.93 HS.283647 0.52 3.27 -0.33 -0.59 0.41 1 2 3 4 5 -1.93 1.93 LOC645811 3.23 3.53 0.19 -0.35 -1.04 1 2 3 4 5 -1.94 1.94 LOC644444 2.30 3.04 -0.26 -0.85 0.45 1 2 3 4 5 -1.94 1.94 LOC728951 0.03 4.04 0.21 0.15 -0.21 1 2 3 4 5 -1.95 1.95 HS.543924 -0.19 3.64 -0.08 -0.27 -0.17 1 2 3 4 5 -1.95 1.95 HS.568234 2.47 3.38 0.29 -0.53 -0.66 1 2 3 4 5 -1.96 1.96 H2BFWT 0.10 2.44 1.64 -1.48 -0.87 1 2 3 4 5 -1.96 1.96 HS.120542 0.24 5.05 2.03 1.13 0.98 1 2 3 4 5 -1.96 1.96 HS.552680 -1.14 2.64 -0.92 -1.29 -0.18 1 2 3 4 5 -1.97 1.97 HS.519819 1.59 3.34 -0.29 -0.60 0.13 1 2 3 4 5 -1.97 1.97 LOC650721 1.85 3.65 1.61 -0.34 0.91 1 2 3 4 5 -1.99 1.99 LOC652846 0.41 3.92 1.78 -0.07 1.80 1 2 3 4 5 -1.99 1.99 DEFB103A 1.73 3.80 0.30 -0.18 -0.35 1 2 3 4 5 -1.99 1.99 HS.540614 0.46 4.02 1.22 0.02 0.19 1 2 3 4 5 -2.00 2.00 HS.583827 -0.04 2.90 0.53 -1.12 0.32 1 2 3 4 5 -2.01 2.01 Table 4 212

HS.580096 -0 .1 3.28 0.99 -0.74 -0.03 1 2 3 4 5 -2.01 2.01 C B 2 -0.17 3.78 0.22 -0.25 -0.32 1 2 3 4 5 -2.02 2.02

NANOS2 1.12 3.22 0.09 -0.83 0.18 1 2 3 4 5 ; -2.02 2.02

HOXD10 -1.35 2.65 -0.12 -1.41 2.30 1 2 3 4 5 , -2.03 2.03 OR8D4 0.25 3.39 0.51 -0.67 -0.28 1 2 3 4 5 -2.03 2.03 FU21062 0.87 3.57 0.53 -0.49 1.61 1 2 3 4 5 -2.03 2.03 HS.543820 -0.38 4.01 0.31 -0.06 -0.38 1 2 3 4 5 -2.03 2.03 OR51E1 2.10 3.08 0.04 -0.99 0.24 1 2 3 4 5 -2.04 2.04 HS.437730 -1.22 3.22 0.00 -0.86 -0.84 1 2 3 4 5 -2.04 2.04 FU42280 -1.13 3.87 1.33 -0.21 1.35 1 2 3 4 5 -2.04 2.04 HS.545588 1.19 3.41 -0.51 -0.69 5.08 1 2 3 4 5 -2.05 2.05 C60RF195 0.85 4.00 0.86 -0.11 0.79 1 2 3 4 5 -2.05 2.05 KRTAP4-11 0.86 3.25 -0.48 -0.86 -0.40 1 2 3 4 5 -2.06 2.06 LOC402100 0.97 3.57 1.94 -0.55 2.90 1 2 3 4 5 -2.06 2.06 ARG1 1.84 3.84 0.02 -0.28 0.04 1 2 3 4 5 -2.06 2.06 LOC441171 0.95 3.45 -0.60 -0.69 0.48 1 2 3 4 5 -2.07 2.07 ANP32D 1.33 2.87 0.13 -1.27 1.44 1 2 3 4 5 -2.07 2.07 FU35848 1.24 3.74 0.48 -0.40 -0.45 1 2 3 4 5 -2.07 2.07 FU40244 5.05 4.52 1.16 0.37 3.92 1 2 3 4 5 -2.08 2.08 HS.480679 0.72 2.57 -0.76 -1.60 0.17 1 2 3 4 5 -2.09 2.09 LOC649198 1.86 3.28 0.15 -0.90 -0.52 1 2 3 4 5 -2.09 2.09 HS.538112 0.77 4.29 0.76 0.11 -0.63 1 2 3 4 5 -2.09 2.09 LOC284009 -0.83 2.96 -0.62 -1.23 -0.83 1 2 3 4 5 -2.09 2.09 KRTAP24-1 0.03 3.76 1.43 -0.42 -0.14 1 2 3 4 5 -2.09 2.09 LOC132203 0.35 3.53 0.54 -0.66 0.69 1 2 3 4 5 -2.09 2.09 TPPP2 4.12 2.52 0.41 -1,67 -0.53 1 2 3 4 5 -2.10 2.10 LOC400095 0.35 3.28 1.38 -0.91 1.01 1 2 3 4 5 -2.10 2.10 LOC643002 0.77 3.24 1.13 -0.96 -0.19 1 2 3 4 5 -2.10 2.10 HS.181536 2.72 3.49 -0.35 -0.73 1.41 1 2 3 4 5 -2.11 2.11 HS.125589 0.18 3.22 1.18 -1.01 0.31 1 2 3 4 5 -2.12 2.12 CNTD1 1.78 3.35 0.18 -0.91 -0.56 1 2 3 4 5 -2.13 2.13 HS.162031 0.95 3.87 0.23 -0.38 -0.19 1 2 3 4 5 -2.13 2.13 HS.171984 -0.82 3.46 -0.48 -0.80 -0.74 1 2 3 4 5 -2.13 2.13 HS.104943 1.31 3.17 1.16 -1.09 -0.07 1 2 3 4 5 -2.13 2.13 SST -0.72 4.24 2.96 -0.02 -0.07 1 2 3 4 5 -2.13 2.13 HS.577164 -0.86 3.87 0.66 -0.41 1.40 1 2 3 4 5 -2.14 2.14 HS.195726 1.48 3.88 -0.05 -0.40 -0.45 1 2 3 4 5 -2.14 2.14 KCNS3 0.37 3.43 0.15 -0.87 2.94 1 2 3 4 5 -2.15 2.15 HS.543516 4.17 4.37 1.28 0.07 2.45 1 2 3 4 5 -2.15 2.15 EBF2 1.45 4.14 0.62 -0.17 0.61 1 2 3 4 5 -2.15 2.15 LOC643082 0.48 5.01 1.79 0.70 1.50 1 2 3 4 5 -2.15 2.15 HS.131297 1.07 3.86 1.86 -0.45 0.79 1 2 3 4 5 -2.16 2.16 HS.214174 0.07 4.17 -0.04 -0.16 0.06 1 2 3 4 5 -2.16 2.16 LOC440570 -0.01 4.31 2.50 -0.02 -0.49 1 2 3 4 5 -2.17 2.17 HS.134650 -0.78 3.74 0.57 -0.60 -0.56 1 2 3 4 5 -2.17 2.17 HMX3 1.41 4.26 0.44 -0.11 -0.64 1 2 3 4 5 -2.18 2.18 CBWD6 1.02 3.20 0.30 -1.20 2.33 1 2 3 4 5 -2.20 2.20 HS.540351 1.46 4.57 0.68 0.16 0.47 1 2 3 4 5 -2.21 2.21 LOC642104 2.65 3.34 -0.49 -1.12 4.05 1 2 3 4 5 -2.23 2.23 Table 4 213 HS.564724 -0.03 6.01 4.72 1.54 -0.77 1 2 3 4 5 -2.23 2.23 FAM83B 1.19 3.08 -0.24 -1.42 -0.20 1 2 3 4 5 -2.25 2.25 HS.128325 0.59 3.93 2.05 -0.58 1.35 1 2 3 4 5 -2.26 2.26 PLUNC -0.11 3.94 2.30 -0.57 0.38 1 2 3 4 5 -2.26 2.26 HS.123398 -0.26 3.41 -0.01 -1.11 0.94 1 2 3 4 5 -2.26 2.26 HS.201822 -0.32 3.89 -0.45 -0.65 0.25 1 2 3 4 5 -2.27 2.27 CHRDL1 -0.16 3.47 1.05 -1.09 0.14 1 2 3 4 5 -2.28 2.28 HS.565325 2.16 3.39 1.83 -1.19 -0.52 1 2 3 4 5 -2.29 2.29 HS.540137 0.69 5.66 1.80 1.08 -1.22 1 2 3 4 5 -2.29 2.29 HS.443361 6.11 2.32 -0.83 -2.32 -2.12 1 2 3 4 5 -2.32 2.32 HS.580561 0.60 3.57 -0.90 -1.08 -0.32 1 2 3 4 5 -2.33 2.33 HS.147700 -0.45 4.00 0.09 -0.69 0.62 1 3 4 5 -2.35 2.35 GABRQ 0.85 3.18 0.58 -1.54 1.71 1 2 3 4 5 -2.36 2.36 LOC642566 1.22 4.45 0.44 -0.28 -0.24 1 2 3 4 5 -2.36 2.36 HS.544895 5.88 3.36 0.28 -1.37 -0.35 1 2 3 4 5 -2.37 2.37 HS.545746 -0.37 4.43 1.47 -0.31 -0.12 1 2 3 4 5 -2.37 2.37 OR7A10 0.17 4.08 -0.38 -0.69 -0.41 1 2 3 4 5 -2.38 2.38 LOC645908 -0.60 3.63 0.14 -1.22 0.78 2 3 4 5 -2.43 2.43 HS.515322 0.27 3.70 1.25 -1.17 -1.06 1 2 3 4 5 -2.44 2.44 PCDHA3 -0.06 2.73 1.48 -2.15 0.86 1 2 3 4 5 -2.44 2.44 HS.582854 0.50 5.05 2.53 0.15 -0.61 1 3 4 5 -2.45 2.45 KRTHA5 1.01 5.51 0.70 0.59 0.38 1 2 3 4 5 -2.46 2.46 OR5AK2 2.15 4.41 1.37 -0.52 0.18 1 2 3 4 5 -2.46 2.46 HS.565442 -0.96 4.54 3.55 -0.40 0.27 1 2 3 4 5 -2.47 2.47 SLC38A4 0.74 4.71 1.85 -0.24 -0.30 1 2 3 4 5 -2.48 2.48 LOC641311 1.23 4.61 0.44 -0.36 1.22 1 2 3 4 5 -2.49 2.49 LOH3CR2A -0.52 5.22 0.66 0.22 -0.54 1 3 4 5 -2.50 2.50 LOC652437 0.42 5.24 1.97 0.20 -0.40 1 2 3 4 5 -2.52 2.52 HS.580142 -0.09 4.49 0.35 -0.56 -0.61 1 2 3 4 5 -2.53 2.53 LOC642948 4.15 3.72 1.76 -1.35 3.01 1 2 3 4 5 -2.54 2.54 HS.552808 -0.62 4.80 2.25 -0.30 -1.09 1 2 3 4 5 -2.55 2.55 HS.544382 0.36 5.15 4.20 -0.01 2.30 1 2 3 4 5 -2.58 2.58 CELP -0.90 4.29 -0.72 -0.90 1.89 1 3 4 5 -2.59 2.59 LOC440005 2.10 2.87 -0.13 -2.34 -0.81 1 2 3 4 5 -2.61 2.61 LOC647869 0.83 5.15 0.03 -0.07 -0.38 1 2 3 4 5 -2.61 2.61 HS.543330 2.39 4.95 0.97 -0.29 0.79 1 2 3 4 5 -2.62 2.62 LOC648521 3.87 4.99 1.13 -0.25 1.24 1 2 3 4 5 -2.62 2.62 HS.562352 -0.03 3.77 3.62 -1.50 1.88 1 2 3 4 5 -2.64 2.64 CRTAC1 0.56 6.45 1.40 1.16 -0.34 1 2 3 4 5 -2.64 2.64 HS.378923 0.05 5.50 0.99 0.18 0.25 1 2 3 4 5 -2.66 2.66 HS.353127 2.61 4.18 1.48 -1.15 1.32 2 3 4 5 -2.66 2.66 HS.561702 0.19 4.96 0.67 -0.37 0.77 1 2 3 4 5 -2.66 2.66 LOC650905 4.26 5.22 0.04 -0.11 2.76 1 2 3 4 5 -2.66 2.66 HS.539973 -0.32 5.14 2.03 -0.20 1.06 1 2 3 4 5 -2.67 2.67 HS.434311 0.74 3.81 0.63 -1.55 0.70 1 2 3 4 5 -2.68 2.68 HS.545273 -0.31 4.63 -0.42 -0.76 2.29 1 2 3 4 5 -2.70 2.70 HS.104829 1.23 5.12 0.24 -0.32 2.21 1 2 3 4 5 -2.72 2.72 HS.134634 2.68 5.27 0.49 -0.20 1.51 1 2 3 4 5 -2.73 2.73 HS.134739 0.98 3.80 1.66 -1.70 0.81 1 2 3 4 5 -2.75 2.75 Table 4 214

HS.546134 0.04 4÷77 0.25 -0.73 -0.55 1 2 3 4 -2.75 2.75 LOC652667 -0.20 4.85 -0.12 -0.66 0.05 1 2 3 4 5 ; -2.76 2.76 HS.576427 -1.01: 6.45 1.87 0.89 -0.03 1 2 3 4 5 -2.78 2.78 LOC642120 -0.15! 4.96 0.00 -0.67 0.61 1 2 3 4 5 -2.82 2.82 HS.559682 1.14 1 5.23 0.98 -0.47 1.98 1 2 3 4 5 -2.85 2.85 MUPCDH 0.07 4.86 0.05 -0.87 -0.02 1 2 3 4 5 : -2.87 2.87 LOC646342 -0.58 4.20 0.27 -1.55 1.68 1 2 3 4 -2.88 2.88 HS.567169 -0.12 5.36 1.14 -0.44 0.26 1 2 3 4 5 -2.90 2.90 LOC652463 0.70 5.75 0.14 -0.11 -0.04 1 2 3 4 5 -2.93 2.93 SLC2A7 3.91 6.03 0.88 0.15 0.10 1 2 3 4 5 -2.94 2.94 KIAA1202 0.97 4.91 3.21 -1.03 0.44 1 2 3 4 5 -2.97 2.97 HS.577706 1.02 5.56 0.93 -0.43 0.91 1 2 3 4 5 -3.00 3.00 HS.53687 1.82 6.15 0.74 0.12 1.03 1 2 3 4 5 -3.02 3.02 SFTPA2B -0.84 5.54 -0.31 -0.52 -0.36 1 2 3 4 5 -3.03 3.03 HS.44210 2.25 5.76 0.85 -0.32 -1.77 1 2 3 4 5 -3.04 3.04 HS.551300 -0.21 5.67 -0.36 -0.43 0.07 1 2 3 4 5 -3.05 3.05 HS.543006 0.40 5.70 -0.33 -0.49 0.49 1 2 3 4 5 -3.09 3.09 HS.580377 0.54 6.05 1.50 -0.17 -0.31 1 2 3 4 5 -3.11 3.11 HS.562048 1.05 5.99 1.63 -0.23 -0.70 1 2 3 4 5 -3.11 3.11 HS.511485 1.91 6.26 1.74 -0.05 -0.54 1 2 3 4 5 -3.15 3.15 SSX8 -1.81 4.60 -1.69 -1.83 0.35 1 2 3 4 5 -3.21 3.21 HS.551381 5.07 6.41 0.80 -0.05 -0.80 1 2 3 4 5 -3.23 3.23 HS.46756 -1.05 6.74 1.66 0.23 1.85 1 2 3 4 5 -3.25 3.25 LOC645953 1.01 6.43 0.28 -0.16 -1.00 1 2 3 4 5 -3.29 3.29 HS.104789 1.31 6.13 -0.30 -0.51 0.03 1 2 3 4 5 -3.32 3.32 LOC439985 2.50 6.15 1.07 -0.53 -0.76 1 2 3 4 5 -3.34 3.34 HS.526433 1.27 6.38 0.53 -0.76 0.94 1 2 3 4 5 ; -3.57 3.57 LOC642140 -1.44 6.17 -0.65 -1.08 -1.52 1 2 3 4 -3.62 3.62 LOC649775 -0.06 6.12 -0.58 -1.17 0.68 1 2 3 4 5 -3.65 3.65 HS.562547 -0.52 6.38 0.32 -0.93 -0.68 1 2 3 4 5 -3.66 3.66 HS.364104 0.82 5.96 0.98 -1.75 0.24 1 2 3 4 5 -3.85 3.85 EYA1 -0.41 5.86 1.35 -1.97 0.72 1 2 3 4 5 -3.92 3.92 GPR88 0.72 7.36 -0.09 -0.51 -0.48 1 2 3 4 5 -3.93 3.93 LOC648628 -1.06 6.34 0.17 -1.58 1.06 1 2 3 4 5 -3.96 3.96 Claims:

1. A method for detecting administration of a substance to a subject wherein said method comprises:

(a) obtaining a biological sample from said subject; and

(b) analyzing said biological sample to determine expression levels of one or more genes wherein change in one or more said expression levels of said one or more genes in said biological sample, when compared to a control sample, is indicative of administration of said substance to said subject.

2. A method for screening one or more biological samples from one or more subjects to determine whether a substance was administered to said one or more subjects, wherein said method comprises:

(a) obtaining said one or more biological samples from said one or more subjects; and

(b) analyzing said one or more biological samples to determine expression levels of one or more genes

wherein change in said expression levels of said one or more genes in said one or more biological samples, when compared to a control sample, is indicative of administration of said substance to said one or more subjects.

3. The method according to claim 1 or 2 wherein said substance is an antagonist or agonist.

4 . The method according to claim 1 to 2 wherein said substance is an anabolic agent, a hormone, a hormone antagonist, a hormone modulator, a growth factor, a beta-2 agonist, a diuretic, a masking agent, a stimulant, a narcotic, a cannabinoid, a glucocorticosteriod, or a beta-blocker.

5 . The method according to any one of claims 1 to 4 wherein the substance is a growth hormone, insulin-like growth factor (IGF-1), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), mechano growth factor (MGF), platelet-derived growth factor (PDGF), vascular-endothelial growth factor

(VEGF).

6 . The method according to claim 5 wherein said growth hormone is a recombinant human growth hormone (rhGH). 7. The method according to any one of claims 1 to 6 wherein expression levels are associated with specific SNP populations of said one or more genes.

8 . The method according to any one of claims 1 to 6 wherein expression levels are determined by quantifying transcriptional products of said one or more genes.

9 . The method according to claim 8 wherein said transcriptional products are RNA.

10. The method according to claim 9 wherein said RNA is selected from the group comprising mRNA, microRNA, ribosomal RNA and ds RNA.

11. The method according to any one of claims 8 to 10 wherein said transcriptional products are quantified by using rolling-circle replication.

2 . The method according to any one of claims 1 to 6, 8 to 1 wherein said expression levels are determined by quantifying translational products from transcriptional products of said one or more genes.

13. The method according to claim 2 wherein said translational products are polypeptides and/or protein.

14. The method according to claim 12 or 13 wherein said translational products are quantified by using an ELISA technique.

15 . An isolated gene when detected by the method according to any one of claims 1 to 14.

16. The isolated gene of claim 14 wherein said gene is selected from Tables 1 to 4 and Figures 1 to 10.

17. The isolated gene of claim 15 or 16 wherein said gene is WFIKKN2.

18. A translational product or a transcriptional product of the gene of any one of claims 15 to 17.

19 . The translational product of claim 18 where said product is GASP-1 . 20. Use of one or more genes for detecting administration of a substance to a subject wherein said use comprises:

(a) obtaining a biological sample from said subject; and

(b) analyzing said biological sample to determine expression levels of said one or more genes

wherein change in one or more said expression levels of said one or more genes in said biological sample, when compared to a control sample, is indicative of administration of said substance to said subject.

21. Use of one or more genes for screening one or more biological samples from one or more subjects to determine whether a substance was administered to said one or more subjects, wherein said use comprises:

(a) obtaining said one or more biological samples from said one or more subjects; and

(b) analyzing said one or more biological samples to determine expression levels of said one or more genes

wherein change in said expression levels of said one or more genes in said one or more biological samples, when compared to a control sample, is indicative of administration of said substance to said one or more subjects.

22. Use of one or more compounds to determine administration of a substance to a subject, wherein said use comprises:

(a) obtaining a biological sample from the subject; and

(b) measuring one or more expression levels of one or more genes with said one or more compounds by quantifying a number of transcriptional and/or translational products of said one or more genes; and

wherein change in said number of transcriptional and/or translational products of said one or more genes in said biological sample, when compared to a control sample, is indicative of administration of said substance to said subject.

23. Use according to any one of claims 20 to 22 wherein said substance is an antagonist or agonist. 24. Use according to claim 23 wherein said substance is an anabolic agent, a hormone, a hormone antagonist, a hormone modulator, a growth factor, a beta-2 agonist, a diuretic, a masking agent, a stimulant, a narcotic, a cannabinoid, a glucocorticosteriod, or a beta-blocker.

25. Use according to claim 24 wherein the substance is a growth hormone, insulin-like growth factor (IGF-1), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), mechano growth factor

(MGF), platelet-derived growth factor (PDGF), vascular-endothelial growth factor (VEGF).

26. Use according to claim 25 wherein said growth hormone is a recombinant human growth hormone (rhGH).

27. Use according to claim 22 wherein said one or more compounds comprises one or more polynucleotides and/or one or more polypeptides.

28. Use according to claim 27 wherein said one or more polynucleotides encodes for said one or more polypeptides.

29. Use according to claim 27 or 28 wherein said one or more polypeptides comprise a full-length and/or wild-type sequence of one or more said translational products.

30. Use according to claim 27 or 28 wherein said one or more polypeptides are recombinants, variants, analogues, derivatives or fragments of said one or more translational products of said one or more transcriptional products encoded by one or more genes selected from Tables 1 to 4 and Figures 1 to

10.

31. Use according to any one of claims 28 to 30 wherein said one or more polypeptides bind directly or indirectly to said translational product of claim 19 or 19.

32. Use according to claim 20 or 23 wherein said analysis is quantitative, qualitative, semi¬ quantitative or semi-qualitative.

33. Use according to claim 32 wherein quantification of said translational product is determined by an immunoassay. 34. Use according to claim 32 wherein said immunoassay is selected from the group comprising flow cytometry, an enzyme-linked immunoassay, a radioimmunoassay, and an immunoassay comprising a biosensor.

35. Use according to claim 27 or 28 wherein said one or more polynucleotides are present in an expression construct.

36. Use according to claim 35 wherein said one or more polynucleotides are operably linked to a promoter.

37. Use according to claim 35 or 36 wherein a host cell is transformed with the expression construct.

38. A kit when used for detecting administration of a substance to a subject, wherein said kit comprises means for analysing a biological sample obtained from said subject to determine expression levels of one or more genes wherein change in said one or more expression levels of said one or more genes in said biological sample, when compared to a control sample, is indicative of administration of said substance to said subject.

39. A kit when used for screening one or more biological samples from one or more subjects to determine whether a substance was administered to said one or more subjects, wherein said kit comprises means for analyzing said one or more biological samples to determine expression levels of one or more genes wherein change in said expression levels of said one or more genes in said one or more biological samples, when compared to a control sample, is indicative of administration of said substance to said one or more subjects.

40. The method or use or the kit of any of the preceding claims wherein said change in expression levels of said one or more genes is detected about one week from the last administration of said substance.

41. The method or use or the kit of any of the preceding claims wherein said change was detected about 8 days from said last administration. 42. The method or use or the kit of any of the preceding claims wherein said change was detected greater than about a week from said last administration.

43. The method or use or the kit of any of the preceding claims wherein said change was detected greater than about two weeks from said last administration.

44. The method or use or the kit of any of the preceding claims wherein said change was detected about 5 days from said last administration.

45. The method or use or the kit of any of the preceding claims wherein said change was detected greater than about three weeks from said last administration.

46. The method or use or the kit of any of the preceding claims wherein said change was detected about 22 days from said last administration.

47. The method or use or the kit of any of the preceding claims wherein said change was detected greater than about four weeks from said last administration.

48. The method or use or the kit of any of the preceding claims wherein said change was detected about 29 days from said last administration.

49. The method or use or the kit of any of the preceding claims wherein said expression levels of one or more genes increases between the day of the last administration (day 0) and day 8, 15, 22 or 29; or between day 8 and day 15, 22 or 29; or between day 15 and day 22 or 29; or between day 22 and day 29.

50. The method or use or the kit of any of the preceding claims wherein said one or more genes is selected from Table 1.

5 1. The method or use or the kit of any of the preceding claims wherein said one or more genes is selected from the group comprising HS. 123362, HS. 148699, LOC728763, OR10K2, LRRC10,

WFIKKN2, LOC652139, HS.543090, HS.439050, LOC284428, ARHGAP29, GPR1 11, HS.544930,

LOC647582, HS.566552, OR52B2, LOC653225, FBX017, HS.121775, LOC646484, SPEM1, HS.163781, MGC39606, HS.147255, CDC42BPG, LRIT2, FMR1NB, HS.545435, INSL6, GLRA2, 0R13J1,

HS.568640, LOC653412, HS.538738, SLC36A2, HSD17B2, S100A7, OR51B6, HS.560015, HS.543248,

C40RF28, LOC644431, CHRND, CYP2W1, HS.563770, HS.543479, LRP4, HS.570624, HS.570433,

LOC650568, HS.544526, CHRNB2, HS.541735, HS.469608, HS.1 19816, HS.575834, ATP4A, PCDHB12,

OR1 , HS.554090, HS.97443, HS.277205, HS.539654, HS.156470, KCNQ5, MGC16291, LOC651655,

ZNF678 and MT1M.

52. The method or use or the kit of any of the preceding claims wherein said one or more genes is WFIKKN2.

53. The method or use or the kit of any of the preceding claims wherein said expression levels of one or more genes decreases between the day of the last administration (day 0) and day 8, 15, 22 or 29; or between day 8 and day 15, 22 or 29; or between day 15 and day 22 or 29; or between day 22 and day

29.

54. The method or use or the kit of any of the preceding claims wherein said one or more genes is selected from Table 2 .

55. The method or use or the kit of any of the preceding claims wherein said one or more genes is selected from the group comprising HS.154607, LOC645811, NFATC2, HS.559868, HS.566874,

HS.568234, LOC645004, HS.551381, TCEAL6, RUNDC3A, HS.567081, DEFB103A, SLC2A7,

HS.584074, HS.1 95726, FLJ35848, HMX3, HS.563829, HS.575043, LOC642660, LOC642425,

HS.559957, HS.44210, HS.5381 12, LOC439985, FAM154B, HS.5531 19, SLC38A4, HS.551291,

HS.147007, LOC647869, LOC440570, HS.51 1485, HS.543820, KRTHA5, HS.582854, HS.580142,

HS.1 20542, LOC652437, HS.562048, SST, HS.540137, LOC645953, HS.552808, HS.580377,

LOH3CR2A, CRTAC1, HS.564724, HS.576427 and LOC642140.

56. The method or use or the kit of any of the preceding claims wherein said substance is selected from the group comprising recombinant human GH, cadaveric GH or any other non endogenous

GH that is administrable to a subject.

57. The method or use or the kit of any of the preceding claims wherein said biological sample is selected from the group comprising bodily fluid and tissue. 58. The method, use or kit of claim 57 wherein said bodily fluid or tissue comprises blood, serum, plasma, lymph, thymus, lymph node, spleen, bone marrow or tonsil or combinations thereof.

59. The method, use or kit of claim 57 wherein said biological sample is a blood sample.

60. The method, use or kit of claim 58 wherein plasma is collected from said blood.

6 1. The method, use or kit of claim 58 wherein peripheral blood mononuclear cells (PBMCs) are isolated from said plasma.

62. The method or use or the kit of any of the preceding claims wherein said control sample comprises a biological sample from one or more subjects who have not been administered exogenous GH.

63. The method or use or the kit of any of the preceding claims wherein said subject is a human or any other animal.

64. The method or use or the kit of any of the preceding claims wherein said subject is selected from the group consisting of human, non-human primate, equine, bovine, ovine, caprine, leporine, avian, feline and canine.

INTERNATIONAL SEARCH REPORT International application No.

PCT/AU20 1/000349

A . CLASSIFICATION O F SUBJECT MATTER

Int. CI.

C12Q 1/68 (2006.0 1)

According to International Patent Classification (IPC) or to both national classification and IPC

B . FIELDS SEARCHED

Minimum documentation searched. (classification system followed by classification symbols)

Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched

Electronic data base consulted during the international search (name of data base and, where practicable, search terms used) WPI, EPODOC, MEDLINE, HCA, BIOSIS. WFIKKN, GASP-1, doping, drug abuse, administer, prohibited substance, drug, compound, agent, performance enhancing, biomarker, gene expression, RNA, microarray, protein level, ELISA, expression profile, human growth hormone, somatotropin, GF- , FGF, HGF, MGF, PDGF,VEGF, detect, measme, quantify and like terms

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation o f document, With indication, where appropriate, of the relevant passages Relevant to claim No. WO 2007/0 19595 A2 (ARC SED3ERSDORF RESEARCH GMBH) 22 February 2007 See: abstract; page 14-1 5 ; claims 5 and 16-1 8 ; figure

MITCHELL, C.J. et al., 'Detection of Growth Hormone Doping by Gene Expression Profiling of Peripheral Blood' The Journal of Clinical Endocrinology an Metabolism. 2009, vol. 94, pages 4703-4709 X See: abstract; page 4707, column 1, paragraph ; figure 1 1- 6, 18, 20- 64

PAPARINI, A . et al., 'Individuazione di geni candidati e profili d'espressione, come indicator! molecolari d assunzione di sostanze dopanti' (Identification of candidate genes and expression profiles, as doping biomarkers) Annali di Igiene. 2007, vol. 1 , pages 303-3 1 X See: summary; tables 1 and 2 1-16, 18 and 20-64

X Further documents are listed in the continuation of Box C See patent family annex

* Special categories of cited documents: "A" document defining the general state of the art which is "T" later document published after the international filing date or priority date and not in not considered to be of particular relevance conflict with the application but cited to understand the principle or theory underlying the invention "E" earlier application or patent but published on orafter the "X" document of particular relevance; the claimed invention cannot be considered novel international filing date or cannot be considered to involve an inventivestep when the document is taken alone "L" document which may throw doubts on priority c!aim(s) "Y" document of particular relevance; the claimed invention cannot be considered to or which is cited to establish the publication date of involve an inventivestep when the document is combined with one or more other another citation or other special reason (as specified) such documents, such combination being obvious to a person skilled in the art "O" document referring to an oral disclosure, use, exhibition „ . or other means document member of the same patent family "P" document published prior to the international filing date but later than the priority date claimed Date of the actual completion of the international search Date " " international search report 24 May 201 1 Name and mailing address of the ISA/AU Authorized officer ELLA J NGE TH AUSTRALIAN PATENT OFFICE PO BOX 200, WODEN ACT 2606, AUSTRALIA AUSTRALIAN PATENT OFFICE E-mail address: [email protected] .au (ISO 90 Quality Certified Service) Facsimile No. +61 2 6283 7999 Telephone No : +61 2 6283 2032 Form PCT SA 2 0 (second sheet) (¾ly 2009) INTERNATIONAL SEARCH REPORT International application No. PCT/AU20 11/000349 C (Continuation). DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.

FERNANDEZ-PEREZ, L. et al., 'The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy' Clinical Endocrinology. 2 0 (epub 22 October 2009), vol. 7 1, pages 800-806 X See: summary; page 8 1, column 2, paragraph 1; page 802, column 1, paragraph 1; 1- 10, 12-16, table 2 18 and 20-64

KNIESS, A . et al., 'Potential parameters for the detection of hGH doping' Analytical and Bioanalytical Chemistry. 2003, vol. 376, pages 696-700 X See: abstract; page 697, column 1, paragraph 7 and column 2 1-7, 12-14, 20-34, 38-64

LONGOBARDL S. et al., 'Growth Hormone (GH) Effects on Bone and Collagen Turnover in Healthy Adults and Its Potential as a Marker of GH Abuse in Sports: A Double Blind, Placebo-Controlled Study' The Journal of Clinical Endocrinology & Metabolism. 2000, vol. 85, pages 1505-1 5 X See: abstract; page 506, column 2, paragraph 2-3; page 15 ] 1, column 2, paragraph 2; 1-7, 12-14, figure 4 20-34 and 38- 64

KONDAS, K. et al., 'Both WFIKKN l and WFIKKN2 Have High Affinity for Growth and Differentiation Factors 8 and 1 The Journal of Biological Chemistry. 2008, vol. 283, pages 23677-23684 X See: whole of document, in particular page 23678, column 2, paragraph 4 15-19

SAREMI, A . et al., 'Effects of oral creatine and resistance training on serum myostatin and GASP- Molecular and Cellular Endocrinology. 201 0 (epub 22 December 2009), vol. 3 17, pages 25-30 See: abstract 18 and 19

Form PCT/ISA7210 (continuation of second sheet) (July 2009) . PCT /AU201 1/000349

Box No. I Observations where certain claims were found unsearchable (Continuation of item 2 of first sheet)

This international search report has not been established in respect of certain claims under Article 17(2)(a) for the following reasons:; 1. Claims Nos.: . because they relate to subject matter not required to be searched by this Authority, namely:

2. Claims Nos.: because they relate to parts of the international application that do not comply with the prescribed requirements to such an extent that no meaningful international search can be carried out, specifically:

3. I Claims Nos.: because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4(a)

Box No. I Observations where unity of invention is lacking (Continuation of item 3 of first sheet)

This International Searching Authority found multiple inventions in this international application, as follows:

I Ί As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims. . [ ] As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.

I 1 As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:

[See Supplemental Box]

No required additional search fees were timely paid by the applicant Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.:

|_ IThe additional search fees were accompanied by the applicant's protest and, where applicable, the payment of a protest fee.

j The additional search fees were accompanied by the applicant's protest but the applicable

protest fee was not paid within the time limit specified in the invitation. ·. · '

I j No protest accompanied the payment of additional search fees. '

Form PCT/ SA 21 (continuation of Srst sheet (2)) (July 2009) INTERNATIONAL SEARCH REPOR International application No. PCT/AU2G 11/000349 Supplemental Box I (To be used when thg space in any of Boxes I to IV is not sufficient) Continuation of Box No: III

This International Application does not comply with the requirements of unity of invention because it does not relate to one invention or to a group of inventions so linked as to form a single general inventive concept.

This Authority has found that there are different inventions based on the following features that separate the claims into distinct groups:

• Group : Claims 1-4, 6-14 and 20-25, 27-55, 57-61 and 63-64 (in part) and claims 5, 26, 56 and 62 (in full). The feature of methods and kits for detecting the administration of a hormone is specific to this group of claims.

• Group 2 : Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of an anabolic agent is specific to this group of claims.

• Group 3: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a hormone antagonist is specific to this group of claims.

• Group 4: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feamre of methods and kits for detecting the administration of a hormone modulator is specific to this group of claims.

• Group 5 : Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a growth factor is specific to this group of claims.

• Group 6: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a beta-2 agonist is specific to this group of claims. • ' Group 7: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a diuretic is specific to this group of claims.

• Group 8: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a masking agent is specific to this group of claims.

• Group 9 : Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a stimulant is specific to this group of claims.

• Group 10: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The featureof methods and kits for detecting the administration of a narcotic is specific to this group of claims.

• Group 11: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a cannabinoid is specific to this group of claims.

• Group 12: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a glucocorticosteroid is specific to this group of claims.

• Group 13: Claims 1-5, 7-14, 20-25, 27-55, 57-61 and 63-64 (in part). The feature of methods and kits for detecting the administration of a beta-blocker is specific to this group of claims.

• Group 14: Claims 15-19. The feature of isolated genes and their translational or transcriptional products is specific to this group of claims [Continued in Supplemental Box II]

Form PCT/ISA/210 (extra sheet)(July 2009) INTERNATIONAL SEARCH REPORT International application No.

PCT /AU20 11/000349 Supplemental Box I (To be used when the space in any of Boxes I to VIII is not sufficient) Continuation o f Box Nor Supplemental Box I

In addition, each growth hormone and growth factor listed in the claims defines ah additional group of claims within groups 1 and 5.

Furthermore, each gene listed in the claims, Tables 1- 4 and Figures 1- 10 defines a separate invention within each of the groups of claims.

PCT Rule 13 .2, first sentence, states that unity of invention is only fulfilled when there is a technical relationship among the claimed inventions involving one or more of the same or corresponding special technical features. PCT Rule 3.2, second sentence, defines a special technical feature as a feature which makes a contribution over the prior art.

When there is no special technical feature there is no unity of invention.

In the above groups of claims, the identified features may have the potential to make a contribution over the prior art but are not common to all the claims and therefore cannot provide the required technical relationship. The only feature common to all of the claims and which provides a technical relationship among them is methods and means for detecting the administration of a substance by determining a change in the expression level or one or more genes. However this feature does not make a contribution over the prior art because it is disclosed in:

WO 2007/01 9595 A2 (ARG SEIBERSDORF RESEARCH GMBH) 22 February 2007

Therefore in the light of this document this common feature cannot be a special technical feature. Therefore there is no special technical feature present in the claims and the requirements for unity of invention are consequently not satisfied posteriori.

Form PCT/ISA/210 (extra sheet (2))(July 2009) . Information on patent family members PCT/AU201 1/000349

This Annex lists the known "A" publication level patent family members relating to the patent documents cited in the above-mentioned international search report. The Australian Patent Office is in no way liable for these particulars which are merely given for the purpose of information.

Patent Document Cited in Patent Family Member Search Report

WO 2007019595 AT 502370 EP 1934366

Due to data integration issues this family listing may not include 10 digit Australian applications filed since May 2001 .

END OF ANNEX

Form PCT SA 2 0 (patent family annex) (July 2009)