Janelia Farm Conference: Constructing Neural Circuits, April 29-May 2, 2012

Sunday, April 29th

3:00 pm Check-in

6:00 pm Reception (Lobby)

7:00 pm Dinner

8:00 pm Welcome / Opening Remarks (Organizers)

8:05 pm Keynote Talk: Liqun Luo, HHMI/Stanford University Assembly of the fly olfactory circuit

9:05 pm Refreshments available at Bob’s Pub

NOTE: All meals are in the Dining Room All talks are in the Seminar Room Posters are in the Lobby

updated 03/26/12 1 Janelia Farm Conference: Constructing Neural Circuits, April 29-May 2, 2012

Monday, April 30th

7:30 am Breakfast (service ends at 8:45 am)

9:00 am Session 1: Target selection and guidance Chair: Carla Shatz

9:00 am Greg Bashaw, University of Pennsylvania Molecular mechanisms regulating midline axon guidance

9:25 am Carol A. Mason, Columbia University Patterning the visual pathways from eye to brain: Genes and rules for retinal axon decussation, organization, and targeting

9:50 am Iris Salecker, National Institute for Medical Research Layer-specific positional guidance cues control targeting of photoreceptor axons in Drosophila

10:15 am Break

10:45 am Session 2: Target selection and guidance (cont'd) Chair: Sam Pfaff

10:45 am Hitoshi Sakano, University of Tokyo Neural circuit formation in the mouse olfactory system

11:10 am Alex L. Kolodkin, HHMI/ University Molecular cues that regulate neural connectivity in the developing mammalian visual system

11:35 am Andrew D. Huberman, University of California, San Diego Mechanisms that generate functional specificity of visual circuits

12:00 pm Jean-François Cloutier, Montreal Neurological Institute Improper glomerular development in the accessory olfactory bulb of kirrel-3 mutant mice is associated with a loss of male-male aggression

12:25 pm Lunch (service ends at 1:00 pm)

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2:00 pm Session 3: RNA-based guidance mechanisms Chair: David Ginty

2:00 pm Robert Darnell, HHMI/Rockefeller University Mapping RNA control of neural circuits

2:25 pm John G. Flanagan, Harvard Medical School Axon guidance and regeneration: transmembrane receptors and RNA-based regulation mechanisms

2:50 pm Christine E. Holt, University of Cambridge Building connections in the visual system: Role of RNA-based axon guidance

3:15 pm Break

3:45 pm Session 4: Poster highlight talks Chair: Carol Mason

3:45 pm Hwai-Jong Cheng, University of California, Davis Refinement of axonal projections in the developing visual system

4:00 pm Hanmi Lee, Stanford University Activity-dependent structural and functional synapse refinement in the LGN require MHC Class I proteins and are rescued by MHCI H2-Db

4:15 pm Jason W. Triplett, University of California, Santa Cruz Alignment of multimodal sensory input in the superior colliculus through a gradient- matching mechanism

4:30 pm Songhai Shi, Memorial Sloan-Kettering Cancer Center Preferential electrical coupling regulates lineage-dependent microcircuit assembly in the neocortex

4:45 pm Ivo Spiegel, Harvard Medical School Cell-type specific control over synaptic specification and cortical E-I-balance by experience-dependent transcriptional networks in inhibitory interneurons

5:00 pm Poster Reception

6:45 pm Dinner

8:00 pm Keynote Talk: Silvia Arber, Biozentrum, University of Basel and FMI Organizational principles of antagonistic motor circuits

9:00 pm Refreshments available at Bob’s Pub

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Tuesday, May 1st

7:30 am Breakfast (service ends at 8:45 am)

9:00 am Session 5: Plasticity Chair: Larry Zipursky

9:00 am Daniel Feldman, University of California, Berkeley Dynamic regulation of excitation-inhibition balance during whisker map plasticity

9:25 am Marla Feller, University of California, Berkeley Plasticity in direction selective circuits in the retina

9:50 am Mark Hubener, Max Planck Institute of Neurobiology Plasticity of orientation preference in mouse visual cortex

10:15 am Elizabeth Quinlan, University of Driving the recovery from severe deprivation amblyopia

10:40 am Break

11:15 am Session 6: Synapse formation Chair: Christine Holt

11:15 am Joshua Sanes, Harvard University Laminar and lateral specificity in retinal circuitry

11:40 am Michael E. Greenberg, Harvard Medical School Signaling networks that regulate synapse development and cognitive function

12:05 pm Megan E. Williams, University of Utah Evaluating synaptic specificity at developing hippocampal synapses

12:30 pm Lunch (service ends at 1:00 pm)

1:15 pm Tour (optional – meet at reception)

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2:15 pm Session 7: Degeneration / regeneration Chair: Andrew Huberman

2:15 pm Ben A. Barres, Stanford School of Medicine Engulfment and elimination of synapses by mammalian astrocytes

2:40 pm Marc Freeman, University of Massachusetts Medical School/HHMI dSarm/Sarm governs a novel axotomy-induced axon death pathway

3:05 pm Yishi Jin, HHMI/University of California, San Diego Regulation of microtubule dynamics in synapses and axon regeneration

3:30 pm Break

4:15 pm Session 8: Dendritic morphology Chair: Iris Salecker

4:15 pm Wes Grueber, Columbia University Transcriptional regulation of dendrite and axon morphology in Drosophila sensory neurons

4:40 pm Kang Shen, HHMI/Stanford School of Medicine The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans

5:05 pm Poster Reception

7:00 pm Dinner

8:00 pm Refreshments available at Bob’s Pub

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Wednesday, May 2nd

7:30 am Breakfast (service ends at 8:45am)

9:00 am Session 9: Network organization Chair: Tom Jessell

9:00 am David Ginty, HHMI/Johns Hopkins School of Medicine The functional organization of cutaneous low-threshold mechanosensory neurons

9:25 am Yuh-Nung Jan, HHMI/University of California, San Francisco From morphology to function: identification of cellular and molecular components in the mechanosensory circuitry

9:50 am Samuel L. Pfaff, HHMI/Salk Institute for Biological Studies Network properties of spinal locomotor circuits

10:15 am David Feldheim, University of California, Santa Cruz Map formation and alignment in the visual system

10:40 am Break

11:10 am Session 10: Poster Highlight Talks Chair: Silvia Arber

11:10 pm Nicola J. Allen, Stanford University Identification of an astrocyte-derived factor that promotes the formation of excitatory synapses containing GluA1 AMPA glutamate receptors

11:25 am Edward Giniger, National Institutes of Health Abl signaling controls axon guidance in part by regulating the secretory apparatus

11:40 am Hanna Hornberg, Cambridge University RNA binding protein, Hermes, regulates axon guidance, branching and synaptogenesis in the zebrafish developing visual system

11:55 am Closing Remarks

12:00 pm Lunch and Departure (To-go boxes available from servery for those on first shuttle)

12:30 pm First shuttle to Dulles 1:15 pm Second shuttle to Dulles 2:00 pm Last shuttle to Dulles

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