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Chenghua Gu's CV Gu, Chenghua NAME POSITION TITLE Chenghua Gu Professor EDUCATION / TRAINING For each degree program or postdoctoral research experience, list, in reverse chronological order, the institution and location, degree, year completed, field of study and your research mentor, if appropriate DEGREE TRAINING INSTITUTION AND LOCATION YEAR SCIENTIFIC DISCIPLINE (if applicable) MENTOR Johns Hopkins School of Medicine, Baltimore Postdoc 1999-2005 David Ginty Neuroscience Cornell University Medical College, New Cell Biology & York Ph.D 1993-1999 Moses Chao Genetics Beijing Agricultural University, Beijing, Veterinary B.S., D.V.M. 1987-1991 China Medicine Professional Positions 2017-present Professor, Department of Neurobiology, Harvard Medical School, Boston, MA 2014-2017 Associate Professor, Department of Neurobiology, Harvard Medical School, Boston, MA 2006-2013 Assistant Professor, Department of Neurobiology, Harvard Medical School, Boston, MA Significant Professional Activities, Honors, and Awards Scientific Meeting Programming 2017 Co-Organizer, workshop “Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood-Brain Barrier”, National Academies of Sciences 2016 Co-Organizer, conference on “Blood Brain Barrier”, Cold Spring Harbor Laboratory meeting 2016 Program Co-Chair, “Neurovascular Disease” session, International Vascular Biology Meeting 2014 Program Co-Chair, “The Functional Blood Brain Barrier” session, conference on “Blood Brain Barrier” Cold Spring Harbor Laboratory meeting Teaching 2015- Instructor, “Neuro-immunology in Development, Regeneration, and Disease”, Harvard Division of Medical Sciences, for graduate students. 2015- Instructor, “Biological Chemistry & Molecular Pharmacology” Harvard Division of Medical Sciences, for graduate students. 2014 Instructor, “How are neural and vascular networks are coordinated developed?”, Karolinska Institute, Sweden, for graduate students. 2008-2015 Instructor, “Developmental Neurobiology”, Harvard Division of Medical Sciences, for graduate students. Funding and Scientific Review Gu, Chenghua 2017 Ad hoc reviewer, NIH Study Section “Vascular Cell and Molecular Biology” 2016, 2015 Reviewer, NIH PPG Grant 2015 Reviewer, Human frontier Science Program 2014, 2011 Reviewer, Research Foundation Flanders (FWO) 2011 Reviewer, Israel Science Foundation (ISF) 2008-2010 Reviewer, United States-Israel Bi-national Science Foundation Advising and Training 2012- Faculty Advisory Committee, Harvard Office for Postdoctoral Fellows 2011-2015 Admissions Committee, Harvard Program in Biological and Biomedical Sciences (BBS) 2011- Optical Imaging Facility Advisory Committee, Harvard Neurodiscovery Center 2009- Admissions Committee, Harvard Program in Neuroscience Journal Review Activities various- Ad hoc reviewer, Cell, Nature, Science, Neuron, Nature Neuroscience, Nature Medicine, Nature Genetics, Cell Stem Cell, Cell Metabolism, eLife, PNAS, and others Honors and Awards 2016-2021 Howard Hughes Medical Institute Faculty Scholar 2015 The Bernice Grafstein Lecture, Weill Cornell Medical College (“recognize the work of early-mid career women neuroscientists who are making their mark in their respective field”) 2014-2019 NIH Director’s Pioneer Award 2014-2016 Kaneb Fellowship 2014-2016 Blavatnik Biomedical Accelerator Award 2008-2010 Alfred P. Sloan Research Fellowship 2007 Ellison Medical Foundation New Scholar Award in Aging (declined) 2007-2009 Basil O’Connor Starter Scholar Research Award, March of Dimes Foundation 2007-2009 Klingenstein Fellowship Award in the Neurosciences 2007-2010 Whitehall Foundation Award 2007-2009 Armenise-Harvard Foundation Junior Faculty Award 2006 Eleanor and Miles Shore Fellowship, Harvard Medical School 2005 W. Barry Wood, Jr. Young Investigator Award, Johns Hopkins School of Medicine 2003-2005 Individual research grant from Christopher Reeve Paralysis Foundation 2000-2003 NIH NRSA postdoctoral fellowship Peer-Reviewed Publications Andreone, B.J., Chow, B.W., Tata, A., Lacoste, B., Ben-Zvi, A., Bullock, K., Deik, A.A., Ginty, D.D., Clish, C.B., Gu, C., (2017) Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis. Neuron, 94(3) 581-594. Chow, B.W., Gu, C., (2017) Gradual suppression of transcytosis governs functional blood-retinal barrier formation. Neuron, 93(6) 1325-1333. Almasi S, Ben-Zvi A, Lacoste B, Gu C., Miller EL., Xu X, (2016) Joint volumetric extraction and enhancement of vasculature from low-SNR 3-D fluorescence microscopy images. Pattern Recognition, 63:710–718. Gu, Chenghua Kur E, Kim J, Tata A, Comin CH, Harrington KI, Costa LD, Bentley K, Gu C., (2016) Temporal modulation of collective cell behavior controls vascular network topology. Elife. 2016 Feb 24;5. pii: e13212. doi: 10.7554/eLife.13212. Keskin, D., Kim, J., Cooke, V.G., Wu, C.C., Sugimoto, H., Gu C, De Palma, M., Kalluri, R., LeBleu, V.S., (2015) Targeting vascular pericyte in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Rep. 10(7):1066-81. Almasi S, Xu X, Ben-Zvi A, Lacoste B, Gu C., Miller EL., (2015) A novel method for identifying a graph-based representation of 3-D microvascular networks from fluorescence microscopy image stacks. Med Image Anal, 20 (1):208-23. Gelfand, M.V., Hagan, N., Tata, A., Oh, W.J., Lacoste, B., Kang, K.T., Kopycinska, J., Bischoff, J., Wang, J.H., Gu C., (2014) Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. Elife. 2014 Sep 22;3. doi: 10.7554/eLife.03720. Lacoste, B., Comin C.H., Ben-Zvi, A., Kaeser, P.S., Xu, X., Costa, L.F., Gu, C., (2014) Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron, 83(5): 1117-1130. Ben-Zvi, A., Lacoste, B., Kur, E., Andreone, B.J., Mayshar, Y., Yan, H., Gu, C., (2014) Mfsd2a is critical for the formation and function of the blood brain barrier. Nature, 509(7501):507-11. Tata, A., Stoppel, D., Hong, S., Ben-Zvi, A., Xie, T., Gu, C., (2014) An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphoring 3E-PlexinD1 signaling. JCB, 205(4):573-590. Straub, C., Tritsch, N., Hagan, N., Gu, C., Sabatini, B., (2014) Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. J. Neurosci, 34(25):8557-69. Tritsch, N., Oh, W., Gu, C., Sabatini, B., (2014) Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. elife, 2014 Apr 24;3:e01936. doi: 10.7554/eLife.01936. Oh, W., Gu, C., (2013) Establishment of neurovascular congruency in the mouse whisker system by an independent mechanism. Neuron. 80(2):458-469. Kwon, H., Kozorovitskiy, Y., Oh, W., Peixoto, R., Akhtar, N., Saulnier, J. L., Gu, C., Sabatini, B.L., (2012) Cortical synaptogenesis and excitatory synapse number are determined via a Neuroligin-1-dependent intercellular competition. Nature Neuroscience. 15(12):1667-74. Ding, J.B., Oh, W., Sabatini, B.L., Gu, C., (2011) Semaphorin3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nature Neuroscience. 15(2):215-23. Kim, J., Oh, W., Gaiano, N., Yoshida, Y., Gu, C., (2011) Semaphorin3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes & Development. 25(13):1399-411. De Almodovar,C., Fabre, P., Knevels, E., Coulon,C., Segura, I., Haddick, P., Aerts, L., Delattin, N., Strasser, G., Oh, W., Lange, C., Vinckier, S., Haigh, J., Fouquet,C., Henderson, C., Gu, C., Alitalo, K., Castellani, V., Tessier-Lavigne, M., Chedotal, A Charron, F., Carmeliet, P., (2011) VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron. 70(5):966-78. Piper, M., Plachez, C., Zalucki, O., Fothergill, T., Goudreau, G., Erzurumlu, R., Gu, C., Richards, LJ., (2009) Neuropilin 1-Sema Signaling Regulates Crossing of Cingulate Pioneering Axons during Development of the Corpus Callosum. Cereb Cortex. Suppl 1:i11-21. Gu, Chenghua Huber, A. B., Kania, A., Tran, T.S., Gu, C., De Marco, N., Lieberam, I., Johnson, D.,Jessell, T.M., Ginty, D.D., Kolodkin, A.L., (2005) Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. Neuron. 48(6): 949-64. Gammill, L.S., Gonzalez, C., Gu, C., Bronner-Fraser, M., (2005) Guidance of trunk neural crest migration requires Neuropilin-2/Semaphorin3F signaling. Development . 133(1):99-106. Mukouyama, Y., Gerber, H., Ferrara, N., Gu, C., Anderson, D.J., (2005) Peripheral nerve-derived VEGF promotes arteriogenesis via Neuropilin-1-mediated positive-feedback. Development. 132(5):941-952. Gu, C., Yoshida, Y., Livet, J., Reimert, D.V., Mann, F., Merte, J., Henderson, C.E., Jessell, T.M., Kolodkin, A.L., Ginty, D.D., (2005) Semaphorin3E and Plexin-D1 control vascular pattern independently of Neuropilins. Science. 307 (5707) 265-268. Schwarz, Q., Gu, C., Fujisawa , H., Sabelko, K., Golding, M., Cheng, H., Marina Gertsenstein, M., Nagy, A., Taniguchi, M., Kolodkin, A.L., Ginty, D.D., Shima, D.T., Ruhrberg, C., (2004) Vascular endothelial growth factor cooperates with Sema3A to pattern different compartments of the facial nerve. Genes & Development. 18 (22) 2822-2834. Gu, C., Rodriguez, E.R., Reimert, D.V., Shu, T., Fritzsch, B., Richards, L.J., Kolodkin, A.L. Ginty, D.D., (2003) Neuropilin-1 conveys Semaphorin and VEGF signaling during neural and cardiovascular development. Developmental Cell. 5 (1):45-57. Gu, C., Limberg, B.J., Whitaker, G.B., Perman, B., Leahy, D.J., Rosenbaum, J.S., Ginty, D.D.,
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