Janelia Farm Conference: Constructing Neural Circuits, April 29-May 2, 2012 Sunday, April 29th 3:00 pm Check-in 6:00 pm Reception (Lobby) 7:00 pm Dinner 8:00 pm Welcome / Opening Remarks (Organizers) 8:05 pm Keynote Talk: Liqun Luo, HHMI/Stanford University Assembly of the fly olfactory circuit 9:05 pm Refreshments available at Bob’s Pub NOTE: All meals are in the Dining Room All talks are in the Seminar Room Posters are in the Lobby updated 03/26/12 1 Janelia Farm Conference: Constructing Neural Circuits, April 29-May 2, 2012 Monday, April 30th 7:30 am Breakfast (service ends at 8:45 am) 9:00 am Session 1: Target selection and guidance Chair: Carla Shatz 9:00 am Greg Bashaw, University of Pennsylvania Molecular mechanisms regulating midline axon guidance 9:25 am Carol A. Mason, Columbia University Patterning the visual pathways from eye to brain: Genes and rules for retinal axon decussation, organization, and targeting 9:50 am Iris Salecker, National Institute for Medical Research Layer-specific positional guidance cues control targeting of photoreceptor axons in Drosophila 10:15 am Break 10:45 am Session 2: Target selection and guidance (cont'd) Chair: Sam Pfaff 10:45 am Hitoshi Sakano, University of Tokyo Neural circuit formation in the mouse olfactory system 11:10 am Alex L. Kolodkin, HHMI/Johns Hopkins University Molecular cues that regulate neural connectivity in the developing mammalian visual system 11:35 am Andrew D. Huberman, University of California, San Diego Mechanisms that generate functional specificity of visual circuits 12:00 pm Jean-François Cloutier, Montreal Neurological Institute Improper glomerular development in the accessory olfactory bulb of kirrel-3 mutant mice is associated with a loss of male-male aggression 12:25 pm Lunch (service ends at 1:00 pm) updated 03/26/12 2 Janelia Farm Conference: Constructing Neural Circuits, April 29-May 2, 2012 2:00 pm Session 3: RNA-based guidance mechanisms Chair: David Ginty 2:00 pm Robert Darnell, HHMI/Rockefeller University Mapping RNA control of neural circuits 2:25 pm John G. Flanagan, Harvard Medical School Axon guidance and regeneration: transmembrane receptors and RNA-based regulation mechanisms 2:50 pm Christine E. Holt, University of Cambridge Building connections in the visual system: Role of RNA-based axon guidance 3:15 pm Break 3:45 pm Session 4: Poster highlight talks Chair: Carol Mason 3:45 pm Hwai-Jong Cheng, University of California, Davis Refinement of axonal projections in the developing visual system 4:00 pm Hanmi Lee, Stanford University Activity-dependent structural and functional synapse refinement in the LGN require MHC Class I proteins and are rescued by MHCI H2-Db 4:15 pm Jason W. Triplett, University of California, Santa Cruz Alignment of multimodal sensory input in the superior colliculus through a gradient- matching mechanism 4:30 pm Songhai Shi, Memorial Sloan-Kettering Cancer Center Preferential electrical coupling regulates lineage-dependent microcircuit assembly in the neocortex 4:45 pm Ivo Spiegel, Harvard Medical School Cell-type specific control over synaptic specification and cortical E-I-balance by experience-dependent transcriptional networks in inhibitory interneurons 5:00 pm Poster Reception 6:45 pm Dinner 8:00 pm Keynote Talk: Silvia Arber, Biozentrum, University of Basel and FMI Organizational principles of antagonistic motor circuits 9:00 pm Refreshments available at Bob’s Pub updated 03/26/12 3 Janelia Farm Conference: Constructing Neural Circuits, April 29-May 2, 2012 Tuesday, May 1st 7:30 am Breakfast (service ends at 8:45 am) 9:00 am Session 5: Plasticity Chair: Larry Zipursky 9:00 am Daniel Feldman, University of California, Berkeley Dynamic regulation of excitation-inhibition balance during whisker map plasticity 9:25 am Marla Feller, University of California, Berkeley Plasticity in direction selective circuits in the retina 9:50 am Mark Hubener, Max Planck Institute of Neurobiology Plasticity of orientation preference in mouse visual cortex 10:15 am Elizabeth Quinlan, University of Maryland Driving the recovery from severe deprivation amblyopia 10:40 am Break 11:15 am Session 6: Synapse formation Chair: Christine Holt 11:15 am Joshua Sanes, Harvard University Laminar and lateral specificity in retinal circuitry 11:40 am Michael E. Greenberg, Harvard Medical School Signaling networks that regulate synapse development and cognitive function 12:05 pm Megan E. Williams, University of Utah Evaluating synaptic specificity at developing hippocampal synapses 12:30 pm Lunch (service ends at 1:00 pm) 1:15 pm Tour (optional – meet at reception) updated 03/26/12 4 Janelia Farm Conference: Constructing Neural Circuits, April 29-May 2, 2012 2:15 pm Session 7: Degeneration / regeneration Chair: Andrew Huberman 2:15 pm Ben A. Barres, Stanford School of Medicine Engulfment and elimination of synapses by mammalian astrocytes 2:40 pm Marc Freeman, University of Massachusetts Medical School/HHMI dSarm/Sarm governs a novel axotomy-induced axon death pathway 3:05 pm Yishi Jin, HHMI/University of California, San Diego Regulation of microtubule dynamics in synapses and axon regeneration 3:30 pm Break 4:15 pm Session 8: Dendritic morphology Chair: Iris Salecker 4:15 pm Wes Grueber, Columbia University Transcriptional regulation of dendrite and axon morphology in Drosophila sensory neurons 4:40 pm Kang Shen, HHMI/Stanford School of Medicine The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans 5:05 pm Poster Reception 7:00 pm Dinner 8:00 pm Refreshments available at Bob’s Pub updated 03/26/12 5 Janelia Farm Conference: Constructing Neural Circuits, April 29-May 2, 2012 Wednesday, May 2nd 7:30 am Breakfast (service ends at 8:45am) 9:00 am Session 9: Network organization Chair: Tom Jessell 9:00 am David Ginty, HHMI/Johns Hopkins School of Medicine The functional organization of cutaneous low-threshold mechanosensory neurons 9:25 am Yuh-Nung Jan, HHMI/University of California, San Francisco From morphology to function: identification of cellular and molecular components in the mechanosensory circuitry 9:50 am Samuel L. Pfaff, HHMI/Salk Institute for Biological Studies Network properties of spinal locomotor circuits 10:15 am David Feldheim, University of California, Santa Cruz Map formation and alignment in the visual system 10:40 am Break 11:10 am Session 10: Poster Highlight Talks Chair: Silvia Arber 11:10 pm Nicola J. Allen, Stanford University Identification of an astrocyte-derived factor that promotes the formation of excitatory synapses containing GluA1 AMPA glutamate receptors 11:25 am Edward Giniger, National Institutes of Health Abl signaling controls axon guidance in part by regulating the secretory apparatus 11:40 am Hanna Hornberg, Cambridge University RNA binding protein, Hermes, regulates axon guidance, branching and synaptogenesis in the zebrafish developing visual system 11:55 am Closing Remarks 12:00 pm Lunch and Departure (To-go boxes available from servery for those on first shuttle) 12:30 pm First shuttle to Dulles 1:15 pm Second shuttle to Dulles 2:00 pm Last shuttle to Dulles updated 03/26/12 6 .