2018 Inductees Marvin Caruthers...................................................................................2 Stan Honey ............................................................................................3 Sumita Mitra ..........................................................................................4 Arogyaswami Paulraj .............................................................................5 Jacqueline Quinn ..................................................................................6 Ronald Rivest .........................................................................................7 Adi Shamir .............................................................................................8 Leonard Adleman ..................................................................................9 Ching Wan Tang ..................................................................................10 Steven Van Slyke ................................................................................. 11 Warren S. Johnson .............................................................................. 12 Howard S. Jones Jr. ............................................................................. 13 Mary Engle Pennington ....................................................................... 14 Joseph C. Shivers Jr. ........................................................................... 15 Paul Terasaki ........................................................................................ 16 2018 NATIONAL INVENTORS HALL OF FAME INDUCTEE Marvin Caruthers Chemical Synthesis of DNA U.S. PATENT NOS. 4,415,732 & 4,458,066 In the early 1980s, biochemist Marvin Caruthers and his team at Born the University of Colorado-Boulder developed the methods for February 11, 1940 chemically synthesizing DNA — a breakthrough that dramatically advanced biological research and helped launch the biotechnology industry. Caruthers’ work transformed protein and DNA synthesis Primary Connections from highly specialized basic research into a widely used research, • University of Colorado-Boulder, diagnostic and forensic tool. Distinguished Professor of Chemistry and Biochemistry, 1973-present The ability to synthesize DNA, rapidly and in the lab, enables researchers to learn how certain genetic sequences are formed, and • Co-founder of several biotech to locate and isolate genes for selected proteins. Early clinical studies companies including Amgen, Applied on drugs stemming from Caruthers’ techniques showed remarkable Biosystems, Array BioPharma and benefits for patients with severe kidney disease and cancer. miRagen Therapeutics Caruthers began working on improving the reliability of DNA synthesis while in the doctoral program at Northwestern University, Education and continued his research at the University of Wisconsin-Madison • Iowa State University, B.S., Chemistry, and the Massachusetts Institute of Technology. As a faculty member 1962 at the University of Colorado-Boulder, he developed key advances • Northwestern University, Ph.D., such as adopting a more stable solid substrate onto which growing Biochemistry, 1968 molecules could be attached. He also devised methods making it possible to manufacture and ship DNA synthesis reagents on a • University of Wisconsin-Madison, commercial scale. Caruthers’ procedures have been incorporated Postdoctoral Fellowship, 1968-70 into “gene machines” automating synthetic DNA production used • Massachusetts Institute of Technology, by biochemists, biologists, molecular biologists and biophysical Postdoctoral Fellowship, 1970-72 chemists in multiple research applications. More recently, his procedures have been adapted for use with modified inkjet printers to synthesize DNA on glass chips. Key memberships/awards • American Chemical Society (ACS) Award The co-founder of several successful biotech companies, including for Creative Invention, 2014 Amgen and Applied Biosystems, he holds 43 U.S. patents and has received numerous awards, including the 2006 U.S. National Medal of • U.S. National Medal of Science, 2006 Science. • National Academy of Sciences (NAS), Award for Chemistry in Service to Society, 2005 © 2018 National Inventors Hall of Fame, Inc. 2018 NATIONAL INVENTORS HALL OF FAME INDUCTEE Stan Honey Sports Broadcast Graphic Enhancements U.S. PATENT NO. 6,141,060 A pioneer in the field of sports television graphics, Stan Honey Born has transformed the viewing experience of millions of sports fans. April 8, 1955 Innovations developed by Honey and his team at Sportvision, now owned by SMT, include the Virtual Yellow 1st & Ten® Line, introduced on Sept. 27, 1998, during an ESPN-televised game between the Primary Connections Baltimore Ravens and the Cincinnati Bengals. Now ubiquitous in • News Corp., Executive VP for football, the superimposed yellow line has been hailed as one of the Technology, 1992-98 most important developments in sports broadcast technology since • America’s Cup Event Authority, Director the debut of instant replay in 1963. of Technology, 2010-14 Other advances led by Honey at Sportvision include K-Zone™, a • Co-founder of Etak and Sportvision baseball pitch tracking and highlighting system; RACEf/x®, which tracks NASCAR racers using GPS; and LiveLine™, a helicopter- mounted, GPS-tracked camera system first implemented during the Education 2013 America’s Cup in conjunction with GPS tracking on the race • Yale University, B.S., Engineering and boats and marks. Applied Science, 1978 A native of San Marino, Calif., Honey earned his B.S. in engineering • Stanford University, M.S., Electrical and applied science at Yale University. While working as a research Engineering, 1983 engineer at SRI International, he completed his MSEE at Stanford University. He then co-founded Etak Inc., a company that pioneered Key memberships/awards automobile navigation systems and digital mapping that was sold in 1989 to News Corp., where Honey served as executive vice president • 3 National Academy of Television Arts of technology from 1993 until co-founding Sportvision in 1998, where and Sciences Sports Emmy Awards he remained until 2003. • National Sailing Hall of Fame, 2012 Honey holds 31 patents in television graphics and in navigation • Sports Broadcasting Hall of Fame, 2017 technology and tracking. He has received numerous awards, including three Emmys for technical and engineering innovations in sports television broadcasts, and is a member of the Sports Broadcasting Hall of Fame. A professional yachtsman and navigator, Honey was the 2010 Yachtsman of the Year, and is a 2012 inductee of the National Sailing Hall of Fame. As navigator, Honey has set records for transatlantic, transpacific, circumnavigation and 24-hour passages under sail. © 2018 National Inventors Hall of Fame, Inc. 2018 NATIONAL INVENTORS HALL OF FAME INDUCTEE Sumita Mitra Nanocomposite Dental Materials U.S. PATENT NOS. 6,387,981, 6,572,693 & 6,730,156 In the late 1990s, Sumita Mitra, a chemist at 3M Oral Care (the dental Born products division of 3M Company), invented the first dental material February 27, 1949 to include nanoparticles. The new composite, called Filtek™ Supreme Universal Restorative, was a versatile material that mimicked the esthetics of natural teeth, had better polish retention and exhibited superior Primary Connections mechanical properties than existing dental composites. • 3M Company, Corporate Scientist, 1978-2010 Mitra and her multidisciplinary team looked outside the realm of traditional dental materials technologies to develop the innovative • University of Minnesota School of material. They developed unique nanomeric and nanoclustered filler Dentistry, Industrial Director at the particles that they combined to generate a composite system that University of Minnesota’s School had excellent paste-handling properties and, when cured, provided of Dentistry Minnesota Dental superior optical properties both initially and long-term, while exhibiting Research Center for Biomaterials and excellent mechanical strength and wear resistance. Filtek Supreme’s Biomechanics, 2000-10 improvements over standard composites included versatility of use due to its excellent lasting esthetics, ability to withstand fracture, low Education shrinkage during curing and extremely good resistance to wear. Tooth- colored composites provide the ability to preserve more of a patient’s • Presidency University (India), B.S., natural tooth structure and do not pose similar health and environmental Chemistry, 1969 concerns as with amalgam fillings containing mercury. Moreover, Filtek • University of Calcutta (India), M.S., Supreme was attractive enough to fill front teeth, and strong enough for Organic Chemistry, 1972 all teeth, even molars, which exert heavy chewing pressure. • University of Michigan, Ph.D., Organic/ The first-generation Filtek Supreme Restorative was launched in 2002, Polymer Chemistry, 1977 followed by the second generation in 2005. In 2012, 3M ESPE launched the third generation, Filtek Supreme Ultra. The Filtek Supreme product Key memberships/awards line has been highly successful commercially, and it has been used in more than 600 million restorations worldwide since its initial launch. • American Chemical Society (ACS), Regional Industrial Innovation Award, Mitra holds 98 U.S. patents and their international equivalents. Her 2004 inventions have led to many breakthrough dental technologies, including • American Chemical Society, Hero of nanocomposites, resin-modified glass ionomers and