What should you do if you FORGET a and are bothersome, please discuss this with RILPIVIRINE/ dose? your doctor or pharmacist. EMTRICITABINE/ TENOFOVIR If you miss a dose of Odefsey and it is less Rare but serious adverse effects that have than 12 hours from when you normally take been observed are damage to the liver, ALAFENAMIDE it, take the dose immediately with a meal. If especially in patients with long-term hepatitis it is more than 12 hours from when you B or C. This can manifest as jaundice (skin Other NAMES: Odefsey is a grey colored normally take Odefsey , do not take the or eyes turn yellow), dark urine and stools tablet that is a combination of rilpivirine 25 dose and wait until your next scheduled and loss of appetite. mg, emtricitabine 200 mg and tenofovir dose. Do not take 2 doses of Odefsey at alafenamide 25mg the same time, and do not take more than 1 If you have hepatitis B and are taking dose in the same day. Odefsey, do not stop taking the WHY is this drug prescribed? medication without consulting your Why should you not forget to take this doctor first. Stopping Odefsey may This tablet contains tenofovir alafenamide drug? worsen the hepatitis B infection. and emtricitabine, two antiretroviral (anti- HIV) reverse transcriptase inhibitors If you miss doses of this drug, the amount of It is important that you keep your doctor (“nukes”) AND rilpivirine, a non-nucleoside HIV virus in your blood (known as the viral appointments and come for your reverse transcriptase inhibitor (“non-nuke”). load) will start increasing again and your laboratory tests so that your progress It is a convenient single tablet regimen for immune system will be further damaged. A can be followed. treatment of HIV infection in adults and may few missed doses can be enough for the be used in combination with other anti-HIV three components, to stop being active, a What other PRECAUTIONS should you drugs. By using Odefsey consistently, your phenomenon known as resistance. When follow while using this drug? immune system should improve (increase in this happens, other antiretrovirals that work CD4+ count) and you will be better protected in a similar way may also become inactive. You must make sure that you are taking the against infections. Therefore, missing doses of this drug can right dose. If you take higher doses than what decrease treatment options for the future. is prescribed, you may increase the chance Odefsey does not cure AIDS or Please do not stop this drug without talking of having side effects. If you take lower doses completely kill the HIV virus, but helps to to your doctor first. of than what is prescribed, the HIV virus may prevent further damage by slowing down the become resistant to Odefsey . production of new viruses. What ADVERSE EFFECTS can this drug cause? What should you do about them? Certain drugs can increase or decrease the HOW should this drug be taken? effect of rilpivirine, tenofovir alafenamide and Most common adverse effects reported with emtricitabine. Drugs that interact with Generally, the dose is 1 tablet once a day, Odefsey are trouble sleeping, abnormal Odefsey and may alter its effect include: with food. Try to take it at same time of the dreams, headache, nausea, tiredness and  Anticonvulsants: day and swallow it with plenty of water. depression. Carbamazepine (Tegretol, Carbatrol, Epitol), oxcarbazepine (Trileptal), Always take Odefsey with a meal. Less common side effects include skin phenobarbital and phenytoin (Dilantin) rashes, abdominal pain, bloating and  Antimycobacterials: decreased appetite. If these effects occur Rifampin (Rifadin, Rofact)

 Antacids including natural health products you are Aluminium hydroxide, magnesium taking. Some products such as St. John’s

hydroxide or calcium carbonate. Take at wort influence the effect of Odefsey and least 2 hours before or 4 hours after you should not be taken together. take Odefsey  Antifungals: Please inform your doctor if you are RILPIVIRINE Ketoconazole (Nizoral), Itraconazole pregnant. Your doctor can recommend the (Sporanox), Fluconazole (Diflucan) appropriate treatment to help to reduce the +  Antibacterials: risk of passing the HIV virus on to your baby. Clarithromycin (Biaxin) Breastfeeding is NOT recommended if you EMTRICITABINE have HIV as you can transmit the virus to  Immunosuppressants: your baby through your breast milk. + Cyclosporine (Neoral), tacrolimus

(Prograf), sirolimus (Rapamune) How should this drug be STORED? TENOFOVIR

Drugs that should not be taken with Odefsey tablets should be stored in a cool ALAFENAMIDE Odefsey are: dry place (below 30C), protected from light  Other medications containing and well out of the reach of children. tenofovir (Atripla, Complera, (ODEFSEY) Descovy, Genvoya, Odefsey, If you have any questions or concerns Stribild, Truvada, Viread) about this drug or if you are experiencing  Other medications containing adverse effects, please discuss them with emtricitabine or lamivudine your pharmacist, doctor or nurse. (Atripla, Complera, Emtriva, MEDICATION Descovy, Genvoya, Stribild, Write questions or concerns down to Odefsey, Truvada, 3TC, ensure they are addressed. Combivir, Heptovir, Kivexa, FACT SHEET Triumeq, Trizivir) The following pharmacist is available to  Other medications containing answer questions: rilpivirine (Complera, Edurant, Juluca) Pharmacist: ______ Adefovir (Hepsera) Telephone: ______ Proton pump inhibitors: dexlansoprazole (Dexilant®), Reference: Product Monograph Odefsey(rilpivirine/ esomeprazole (Nexium®, Vimovo®), tenofovir alafenamide/emtricitabine). Gilead Canada Inc, lansoprazole (Prevacid®), Mississauga, ON, 2018. omeprazole (Losec®, Olex®), Prepared by Zubeir Khan (PharmD student 2019).

pantoprazole sodium (Pantoloc®, Additional medication fact sheets and updates may be found at: https://hivclinic.ca/ Panto IV®), rabeprazole (Pariet®)

Inform your doctor and pharmacist of all prescribed and non-prescribed drugs