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[email protected] Product datasheet for TL312444 HIST1H2AC Human shRNA Plasmid Kit (Locus ID 8334) Product data: Product Type: shRNA Plasmids Product Name: HIST1H2AC Human shRNA Plasmid Kit (Locus ID 8334) Locus ID: 8334 Synonyms: dJ221C16.4; H2A/l; H2AFL; HIST1H2AC Vector: pGFP-C-shLenti (TR30023) Format: Lentiviral plasmids Components: HIST1H2AC - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 8334). 5µg purified plasmid DNA per construct Non-effective 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. RefSeq: NM_003512, NM_003512.1, NM_003512.2, NM_003512.3, BC085010, BC017379, BC050602, NM_003512.4 Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015] shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus.