Richard J. Schmidt PhD Pharmacist ~ Chartered Chemist ~ Intellectual Property Realisation Consultant 117 Andrew Road Penarth CF64 2NW, UK Tel. +44 (0)2920 703865 www.inter--face.org [email protected]

➢➢ Qualifications

Jun 1973 BPharm (Hons); Second Class (Upper); University of London Jul 1974 MPS; from 1988: MRPharmS Dec 1977 PhD (Lond.) Apr 1985 FLS Apr 1996 CChem, FRSC Oct 2013 FFRPS

Current Professional Registration General Pharmaceutical Council (GPhC) No. 2019451 Royal Society of Chemistry (RSC) No. 0333848

Member of the UK Register of Expert Witnesses (http://www.jspubs.com/Experts/register/reg_index.cfm) ➢➢

➢➢ Professional Career Summary

Jan 2000 – to date Business consultant (intellectual property realisation; patent drafting; EPO patent opposition; medical device / cosmetics product registration; information technology; information retrieval; forensic / expert report / legal brief writing) Sep 1997 – Jan 2000 Senior Research Scientist, Wound Care Research Group, Johnson & Johnson Medical Ltd, Gargrave, UK Apr 1983 – Aug 1997 Honorary Scientific Officer in the Dermatology Department, University Hospital of Wales (now University of Wales College of Medicine) Apr 1979 – Aug 1997 Lecturer, Welsh School of Pharmacy, UWC (formerly UWCC / UWIST) Cardiff Apr 1978 – Mar 1979 Temporary Lecturer, Undergraduate School of Studies in Pharmacy, University of Bradford Dec 1977 – Mar 1978 Superintendent pharmacist in a community pharmacy Jul 1974 – to date Occasional and ongoing work as a locum community pharmacist ➢➢

➢➢ Publishing / IT Activities

Jan 1986 Co-founder of STS Publishing, Welsh School of Pharmacy, UWIST, Cardiff. Allocated the publisher prefix 0-948917 Jun 1986 Published "Child Care Through the Centuries" (Editors Cule J & Turner T) [ ISBN 0-948917-00-8 : http://www.worldcat.org/oclc/17620478 – one of the first books to be typeset using a word processor] Jun 1986 Published "Wound Management in Industry" (Editors Turner T, Cockbill S and Caudwell D) [ ISBN 0-948917-01-6 : http://www.worldcat.org/oclc/17442735 ] 1994 - to date Webmaster: BoDD - Botanical Dermatology Database (http://www.botanical-dermatology- database.info/) 1995 - 1997 IT support (MacOS) / Webmaster: Welsh School of Pharmacy, Cardiff University, UK (http:// info.cf.ac.uk/uwcc/phrmy/) 2000 - to date Webmaster: inter--face.org (http://www.inter--face.org/) 2001 - 2017 Webmaster: Martin Biggs Associates (http://www.mba-gbm.com/ ; http://www.ce-marking- authorized-representative.com/) 2012 - 2018 Webmaster: Pharma Sol International Ltd (http://www.pharma-sol-international.com/) ➢➢

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !1 of 18! ➢➢ Analytical experience

As a undergraduate student in the School of Pharmacy, University of London, I received laboratory instruction in Pharmaceutical Analysis and Pharmacognosy. This provided “hands-on” experience of a variety of techniques including gravimetric, volumetric, acidimetric & alkalimetric, and various spectroscopic and spectrometric methods. We also covered microscopy, titrimetry, aquametry, limit tests, alkaloid determinations, and a variety of other pharmacopoeial quality control / assurance determinations.

As a post-graduate research student, I used a variety of analytical techniques commonly applied in the isolation, structure elucidation, and quantification of [toxic] phytochemicals. These included IR & UV-Visible spectroscopy, circular dichroism, nuclear magnetic resonance spectrometry, and mass spectrometry. I also used a variety of chromatographic techniques, both qualitatively and quantitatively, including gas chromatography, high pressure liquid chromatography, thin layer chromatography, and the so-called “hyphenated” technique gas chromatography-mass spectrometry.

As a lecturer in the Bradford University school of pharmacy and then in the Welsh School of Pharmacy, I spent about 18 years teaching many of these methods and techniques, the principles underlying their calibration and validation, and the statistical analysis of data produced. I also gave lectures on advanced spectroscopic and spectrometric methods, including the use of Fourier transform in nuclear magnetic resonance spectrometry.

I have also applied many of these techniques in my own research and have trained and supervised postgraduate students and research associates seeking to apply these techniques in their research projects. ➢➢

➢➢ Toxicology experience

Pharmaceutical drugs have been described as “selectively toxic agents”; selective toxicity is the basis of molecular pharmacology [see, for example, A. Albert (1985) Selective Toxicity. The physico-chemical basis of therapy. 7th edn. London: Chapman and Hall. http://www.worldcat.org/oclc/924597587]. Pharmacists, whilst understanding how drugs can be used therapeutically, also understand how drugs may cause unwanted (toxic) effects, and also understand the interplay between wanted and unwanted effects when different drugs – which in some patients may number in excess of 20 different drugs – are administered to the same patient. In this sense, pharmacy is a branch of toxicology.

During the time I spent lecturing to pharmacy undergraduate students, I was responsible for teaching various aspects of the biochemical toxicology of food , poisonous plants, natural products, and pesticides.

In addition, my research training involved the isolation and characterisation (and safe handling) of some of the most skin- and mucous membrane-irritant compounds known to man, namely mono-and di-esters of various tigliane, ingenane, and daphnane polyols. Subsequent research took me into the field of allergic contact dermatitis, in which I was involved in the isolation, characterisation (and safe handling) of potent contact allergens, including known carcinogens. Therefore, I am appropriately described as a pharmacist / toxicologist / chemist with a special interest in dermatotoxicology. ➢➢

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !2 of 18! ➢➢ Forensic experience

My forensic experience derives from training I received in forensic methodology in Pharmacognosy and Pharmaceutical Analysis laboratory classes at undergraduate level (1969–1973); the teaching of these skills to undergraduates in the Schools of Pharmacy in Bradford University (1978–1979) and Cardiff University (1979– 1997); my own training in research skills to PhD level (1974–1977); and the experience of training and mentoring numerous postgraduate research students in research methodology and thesis preparation (1980– 2000). Classically, pharmacognosy is that area of pharmacy concerned with the microscopic identification and quality control of crude drugs in powdered form. Many classically-trained pharmacognosists such as myself became involved in legal cases as experts in the identification of substances of abuse such as and opium. Perhaps the most notable pharmacognosist in the UK in recent times was Professor Frank Fish (http:// www.heraldscotland.com/opinion/13029880.Frank_Fish/) who was not only Dean of the School of Pharmacy from which I graduated but who also established courses in forensic science in both Strathclyde and London. Slide no. 23 from the Second Professor Frank Fish Memorial Award Lecture delivered by Professor A. Douglas Kinghorn (one of my contemporaries) in October 2013 shows a photograph of UK pharmacognosists taken in the late 1970s – see http://www.inter--face.org/pdfs/frankfish2013slides.pdf ; I am standing 5th from the right.

Throughout my whole professional career, information retrieval has been essential to my work as a research scientist and university lecturer. In the early days, this involved understanding how published information is structured and stratified in so-called primary, secondary and tertiary paper sources. In recent times, the internet and electronic publication has added a new dimension (“IT”). I was for a while responsible in the Welsh School of Pharmacy for providing training to our undergraduates in information retrieval skills.

In addition, my work as a locum community pharmacist, provides daily direct experience of document and signature analysis. Pharmacists are presented with prescriptions, which in the UK can be National Health Service [NHS] or private prescriptions. These are legal documents that have to be written correctly in order to be valid. Some individuals seek to amend their prescriptions prior to presentation at a pharmacy in order to obtain either greater quantities or greater strengths of certain drugs of abuse. Occasionally, pads of prescriptions are stolen. When this occurs, the signature of the physician is also then forged. So, on being presented with a prescription, the first task of every community pharmacists is to ascertain whether the prescription is validly written, signed by the prescriber, and unaltered. A reward is offered to pharmacies in the NHS for each fraudulent prescription detected. So, document examination can be regarded as a generic skill possessed to a greater or lesser extent by every community pharmacist, and especially by those such as myself who spent many years dispensing hand-written prescriptions in the days before the widespread adoption of modern computer technology.

According to Paragraph 9. (1) (a) in Part 2 of the National Health Service (Pharmaceutical and Local Pharmaceutical Services) Regulations 2013 [see page 141 in http://www.legislation.gov.uk/uksi/2013/349/pdfs/ uksi_20130349_en.pdf]:

"A pharmacist may refuse to provide drugs or appliances ordered on a prescription form … where the pharmacist reasonably believes that it is not a genuine order for the person named on the prescription form … for example because the pharmacist reasonably believes it has been stolen or forged.”

Clearly, UK law not only recognises but requires a pharmacist to be capable of determining by simple inspection whether or not a prescription has been forged. This includes the ability to spot that a signature has been forged. And this has to be read in the context that a prescription is a legal document. In the US, the forging of prescriptions is regarded as "Forgery in the second degree …" [Penal Law 170.10.] ➢➢

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !3 of 18! ➢➢ Consultancy Work

1985 Toxicology advisor in the formulation of a new range of toiletries containing material; Marks and Spencer plc 1985 Biomaterial evaluation: performance of Lyofoam C, an activated carbon containing wound management product; Ultra Laboratories Ltd 1989 Technical consultant in the translation of Technologie Pflanzlicher Arzneizubereitungen by List PH & Schmidt PC; Heyden & Sons Ltd 1989 Toxicology advisor on test data for Dermo-Film™; Stiefel Laboratories(UK) Ltd 1989 Invited to join the Database Management Working Group for the "Genera Compositarum" project in preparation for the Kew International Compositae Conference (KWICC), 1994; invited to present a paper on the “Preparation of a Database on the Compositae as a Dermatological Hazard” at an International Conference on COMPOSITAE: SYSTEMATICS, BIOLOGY, UTILIZATION held at Kew, UK 24th July - 5th August 1994 1990 Toxicology advisor on allergenicity problem with MC2000 microporous tape; Coloplast Ltd 1994 – 1996 Consultant in EC Medical Device / Medicinal Product Borderline Discussions; Les Laboratoires Brothiers, Nanterre, France (through Martin Biggs Associates) 1994 – 1997 Consultant in the evaluation of new generation bioactive hydrogel/hydrocolloid wound management products; Smith & Nephew Research Ltd 1995 Contributor to Clairol Hairdye Workshop; Clairol, Inc., Stamford, Connecticut, USA 1995 – 1997 Evaluation of biocompatibility assay data of a new wound management product; ConvaTec / Bristol-Myers Squibb 1996 Contributor to European Community DGXII Agro-Industry Seminar on “The Elderberry Plant: A survey of the clinical, nutritional and industrial potential of the Sambucus species” in Brussels, Belgium 2000 – to date Business consultant working with Martin Biggs Associates (http://www.mba-gbm.com/) and also independently to numerous clients. See also Litigation Support section below. ➢➢

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !4 of 18! ➢➢ Litigation support experience

Mar 2000 Smith & Nephew plc vs Johnson & Johnson ~ EPO Patent Opposition; case no. T 0556/96 - 3.2.2 http://www.epo.org/law-practice/case-law-appeals/recent/t960556eu1.html ; http:// www.epo.org/law-practice/case-law-appeals/pdf/t960556eu1.pdf Provided technology assessment support.

Oct 2001 Steele Greenwood (Solicitors) 17/19 Nicholas Street Burnley, UK Provided expert report on the likelihood that medication that a patient [a long-distance truck driver] was taking had caused confusion and thus contributed to a road traffic accident.

June 2005 R.J. Schmidt vs Google, Inc. https://www.lumendatabase.org/notices/6487

Mar 2006 Nurse Prescribers Ltd vs Department of Health Investigated the provenance of a Department of Health [DH] publication available only as an electronic document, being a 2nd edition of a policy implementation guide that had seemingly been created expeditiously for the purpose of misleading a Court.

Nov 2008 Nurse Prescribers Ltd vs Department of Health Assisted in the drafting of a protective Misfeasance in Public Office Claim.

Apr 2011 Martin Biggs Associates vs On Group Ltd in Guildford County Court, UK Prepared an expert report on cosmetic product ingredient declaration and labelling issues; prepared a rejoinder to erroneous assertions provided in an expert report upon which On Group Ltd placed reliance; carrying out forensic document analysis of three copies of ostensibly the same document to establish fraudulent manipulation of evidence. The case was settled out of court in favour of Martin Biggs Associates.

May 2012 Nurse Prescribers Ltd vs Department of Health Using the Internet Archive (https://archive.org/) and the UK Government Web Archive (http:// webarchive.nationalarchives.gov.uk/), tracked website and document manipulation by the Department of Health [DH] as it seemingly sought to render undiscoverable a key document cited by the DH at a judicial review hearing in February 2004.

Aug 2012 R.J. Schmidt & J. Martin Biggs vs Department of Health Prepared a detailed and substantive Complaint to the UK Parliamentary and Health Service Ombudsman [PHSO] about serial acts of maladministration at the Department of Health [DH].

Sep 2013 Nurse Prescribers Ltd vs Department of Health Assisted in the drafting of an Appeal Briefing document to Counsel. Assisted in the drafting of a rejoinder to preliminary opinion provided by Junior Counsel.

Nov 2013 Martin Biggs vs Tim Cook / Amy Davis Forensic document examination and information retrieval re alleged unlawful execution of legal instruments / fraudulent notarisation.

Dec 2013 Witte Wolk BV vs Lead by Sales LLC Federal Civil Action (Middle Dist. Fl. Tampa Division) Prepared rejoinder to expert report re applicability of the EU RoHS Directive / lead analyses to the certification of e-cigarette rechargeable battery packs. Case settled November 2014.

Jan 2014 R.J. Schmidt vs Vinci Park Services UK Ltd Successful appeal against liability for a parking charge POPLA (http://popla.org.uk/) ref. 9163293401. cont’d

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !5 of 18! Aug 2015 Moira Fairlie vs L’Oreal / Garnier Provided advice on a product safety issue with a view to establishing a causal relationship between the use of a cosmetic product and an adverse skin reaction.

Nov 2015 Yasien Hussain vs Quvera Limited / Jumbogate Limited / Meraj Limited in Northampton County Court, UK Provided expert opinion on pharmaceutical quality control issues leading to personal injury of a colecalciferol preparation seemingly being passed off on the UK market as a copy of a German product with the same name.

Nov 2015 Lorraine Smith vs Coty Provided expert opinion on the likelihood that a perfume product could cause a cold burn in normal use.

May 2016 Cephalon Inc. / Teva Pharmaceuticals USA Inc. vs CP Pharmaceuticals Limited / Wockhardt UK Holdings Limited / Wockhardt Limited (India) Provided expert report on the regulatory status and toxicology / health risks to employees of the arsenic trioxide-containing product Trisenox.

Sep 2016 Barry M Cosmetics Limited vs Swallowfield plc Provided an expert toxicological report / safety assessment on the ingredients of a spray tan product associated with adverse incidents that led to the hospitalisation of end-users.

Feb 2017 Dyfed Powys Police Provided advice on the expected level of professional and ethical conduct in the case of a Reiki practitioner accused of indecent behaviour with a client.

Nov 2017 R vs Ozan Melin & Lisa Ellen Bolster in Bournemouth Crown Court, UK Prepared an Expert Report on the allergenic / toxicologic potential of “Botox”, a branded botulinum toxin product, and of a demonstrably counterfeit version of this product imported from China, and the possibility that symptoms experienced by the Complainants could have arisen from a different cause. ➢➢

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !6 of 18! ➢➢ Refereeing / Peer Review work

Periodicals

Contact Dermatitis Bioresource Technology

Holzforschung Journal of Agricultural and Food Chemistry

Journal of Pharmacy and Pharmacology Journal of Pharmacological and Toxicological Methods

Journal of the Chemical Society of Pakistan Phytotherapy Research

Selbyana [Providing critical appraisal of research manuscripts prior to publication – see my profile at Publons]

Research Charities, etc

Wellcome Trust Science and Engineering Research Council (SERC - CASE) Natural Environment Research Council (NERC) CSO (Chief Scientist Office) – Acute Healthcare Research The Scottish Office, Home and Health Department

[Providing critical appraisal of research grant applications]

➢➢

➢➢ Publications (full list attached as Appendix 1)

Summary

PhD thesis TOTAL: 1 Edited book TOTAL: 1 Electronic book TOTAL: 1 Original scientific research papers TOTAL: 45 Reviews TOTAL: 31 Research reports TOTAL: 9 Abstracts, Posters, Letters, etc TOTAL: 108 Patents TOTAL: 9

TOTAL: 205 ➢➢

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !7 of 18! APPENDIX 1 - Publications List

PhD Thesis

Schmidt R J — Chemical and biological studies on tigliane and daphnane diterpenes of three species, PhD Thesis, University of London (1977)

Edited book

Turner T D, Schmidt R J and Harding K G (Editors) — Advances in Wound Management. John Wiley & Sons, Chichester (1986) [ ISBN 0-471-91312-X : http://www.worldcat.org/oclc/14213941 ]

Electronic book

Schmidt R J — BoDD (Botanical Dermatology Database), 1994 – 2014. An electronic re-incarnation of BOTANICAL DERMATOLOGY by J Mitchell & A Rook, which was originally published in 1979 by Greengrass Ltd, Vancouver [ISBN 0-88978-047-1]. This on-line version, which is under continuous development, is made available with the kind permission of the original authors. Hosted by Cardiff University until 2010 (http://bodd.cf.ac.uk); now migrated to http://www.botanical-dermatology-database.info

Dermatotoxicology (full papers)

Evans F J, Kinghorn A D and Schmidt R J — Some naturrally occurring skin irritants, Acta Pharmacologica et Toxicologica 37(3): 250-256 (1975) [ ISSN 0001-6683 : https://doi.org/10.1111/j.1600-0773.1975.tb00842.x ]

Evans F J, Schmidt R J and Kinghorn A D — A microtechnique for the identification of diterpene ester inflammatory toxins, Biomedical Mass Spectrometry 2(3): 126-130 (1975) [ ISSN 1052-9306 : https://doi.org/10.1002/bms. 1200020304 ]

Evans F J and Schmidt R J — Two new toxins from the latex of Euphorbia poisonii, Phytochemistry 15(2): 333-335 (1976) [ ISSN 0031-9422 : https://doi.org/10.1016/S0031-9422(00)89024-X ]

Schmidt R J and Evans F J — A new aromatic ester diterpene from Euphorbia poisonii, Phytochemistry 15(11): 1778-1779 (1976) [ ISSN 0031-9422 : https://doi.org/10.1016/S0031-9422(00)97483-1 ]

Schmidt R J and Evans F J — The succulent of Nigeria. II. Aliphatic diterpene esters of the latices of E. poisonii Pax and E. unispina N.E. Br., Lloydia 40(3): 225-229 (1977) [ ISSN 0163-3864 : https:// www.ncbi.nlm.nih.gov/pubmed/895380 ]

Schmidt R J and Evans F J — Candletoxins A and B, 2 new aromatic esters of 12-deoxy-16-hydroxy-phorbol, from the irritant latex of Euphorbia poisonii Pax, Experientia 33(9): 1197-1198 (1977) [ ISSN 0014-4754 : https://doi.org/ 10.1007/BF01922325 ]

Schmidt R J and Evans F J — Two minor diterpenes from Euphorbia latex, Phytochemistry 17(8): 1436-1437 (1978) [ ISSN 0031-9422 : https://doi.org/10.1016/S0031-9422(00)94608-9 ]

Evans F J and Schmidt R J — An assay procedure for the comparative irritancy testing of esters in the tigliane and daphnane series, Inflammation 3(3): 215-223 (1979) [ ISSN 0360-3997 : https://doi.org/10.1007/BF00914178 ]

Evans F J and Schmidt R J — The succulent euphorbias of Nigeria. III. Structure and potency of the aromatic ester diterpenes of Euphorbia poissonii Pax, Acta Pharmacologica et Toxicologica 45(3): 181-191 (1979) [ ISSN 0001-6683 : https://doi.org/10.1111/j.1600-0773.1979.tb02380.x ]

Schmidt R J and Evans F J — Investigations into the skin-irritant properties of resiniferonol ortho esters, Inflammation 3(3): 273-280 (1979) [ ISSN 0360-3997 : https://doi.org/10.1007/BF00914184 ]

Schmidt R J and Evans F J — Skin irritants of the sun spurge (Euphorbia helioscopia L.), Contact Dermatitis 6(3): 204-210 (1980) [ ISSN 0105-1873 : https://doi.org/10.1111/j.1600-0536.1980.tb05599.x ]

Schmidt R J and Evans F J — Skin irritant effects of esters of phorbol and related polyols, Archives of Toxicology 44(4): 279-289 (1980) [ ISSN 0340-5761: https://doi.org/10.1007/BF00278035 ]

Schmidt R J and Moult S P — The dermatitic properties of black bryony (Tamus communis L.), Contact Dermatitis 9(5): 390-396 (1983) [ ISSN 0105-1873 : https://doi.org/10.1111/j.1600-0536.1983.tb04435.x ]

Schmidt R J and Kingston T — Testing with musk ambrette and congeners in a case of photosensitivity dermatitis and actinic reticuloid syndrome (PD/AR), Photodermatology 1(4): 195-198 (1984) [ ISSN 0108-9684 : https:// www.ncbi.nlm.nih.gov/pubmed/6531294 ]

Schmidt R J — When is a chrysanthemum dermatitis not a Chrysanthemum dermatitis? The case for describing florists' chrysanthemums as Dendranthema cultivars, Contact Dermatitis 13(2): 115-119 (1985) [ ISSN 0105-1873 : https://doi.org/10.1111/j.1600-0536.1985.tb02515.x ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !8 of 18! Schmidt R J and Kingston T — Chrysanthemum dermatitis in South Wales; diagnosis by patch testing with feverfew (Tanacetum parthenium) extract, Contact Dermatitis 13(2): 120-121 (1985) [ ISSN 0105-1873 : https://doi.org/ 10.1111/j.1600-0536.1985.tb02516.x ]

Schmidt R J and Fernández de Corres L — Allergic contact dermatitis from proprietary topical analgesic sprays containing 3-(aminomethyl)-pyridyl salicylate, Dermatologica 174(6): 272-279 (1987) [ ISSN 0011-9075 : https:// doi.org/10.1159/000249198 ]

Schmidt R J and Khan L — Evidence for the existence of prohapten-activating enzyme in the skin: induction of contact sensitivity to monocrotaline in mice, Current Topics in Contact Dermatitis (Editors Frosch P J, Dooms-Goossens A, Lachapelle J-M, Rycroft R J G and Scheper R). Springer-Verlag, Berlin : 24-30 (1989) [ ISBN 3-540-50568-7 : https:// doi.org/10.1007/978-3-642-74299-6_4 ]

Audicana M, Schmidt R and Fernández de Corres L — Allergic contact dermatitis from nicotinic acid esters, Contact Dermatitis 22(1): 60-61 (1990) [ ISSN 0105-1873 : https://doi.org/10.1111/j.1600-0536.1990.tb01514.x ]

Schmidt R J and Fernández de Corres L — An unusual case of delayed contact sensitivity to black bryony berries (Tamus communis L.), Contact Dermatitis 23(4): 260-261 (1990) [ ISSN 0105-1873 : https://doi.org/10.1111/j. 1600-0536.1990.tb05067.x ]

Schmidt R J, Khan L and Chung L Y — Are free radicals and not quinones the haptenic species derived from urushiols and other contact allergenic mono- and dihydric alkylbenzenes? The significance of NADH, glutathione, and redox cycling in the skin, Archives of Dermatological Research 282(1): 56-64 (1990) [ ISSN 0340-3696 : https://doi.org/ 10.1007/BF00505646 ]

Picardo M, Zompetta C, Marchese C, De Luca C, Faggioni A, Schmidt R J and Santucci B — Paraphenylenediamine, a contact allergen, induces oxidative stress and ICAM-1 expression in human keratinocytes, British Journal of Dermatology 126(5): 450-455 (1992) [ ISSN 0007-0963 : https://doi.org/10.1111/j.1365-2133.1992.tb15115.x ]

Schmidt R J and Chung L Y — Biochemical responses of skin to allergenic and non-allergenic nitrohalobenzenes. Evidence that an NADPH-dependent reductase in skin may act as a prohapten-activating enzyme, Archives of Dermatological Research 284(7): 400-408 (1992) [ ISSN 0340-3696 : https://doi.org/10.1007/BF00372070 ]

Schmidt R J and Chung L Y — Mild heat shock therapy of allergic contact reactions, Contact Dermatitis 28(1): 51-52 (1993) [ ISSN 0105-1873 : https://doi.org/10.1111/j.1600-0536.1993.tb03338.x ]

Schmidt R J and Chung L Y — Perturbation of glutathione status and generation of oxidative stress in mouse skin following application of contact allergenic sesquiterpene lactones and , Xenobiotica 23(8): 889-897 (1993) [ ISSN 0049-8254 : https://doi.org/10.3109/00498259309059416 ]

Read D C and Schmidt R J — An electrochemical approach to the study of prohapten activation: a possible nitroreductase model, Prediction of Percutaneous Penetration Vol 4b, (Editors Brain K R, James V J and Walters K A). STS Publishing, Cardiff : 222-226 (1996) [ ISBN 0-948917-10-5 : http://www.worldcat.org/oclc/222800266 ]

Jones H L, Schmidt R J and Hadgraft J — The development of a database of chemical and physicochemical parameters for predicting contact allergenic potential of new chemical entities, Prediction of Percutaneous Penetration Vol 4b, (Editors Brain K R, James V J and Walters K A). STS Publishing, Cardiff : 227-231 (1996) [ ISBN 0-948917-10-5 : http://www.worldcat.org/oclc/222800266 ]

Kirby A J and Schmidt R J — The antioxidant activity of Chinese herbs for eczema and of placebo herbs I, Journal of Ethnopharmacology 56(2): 103-108 (1997) [ ISSN 0378-8741 : https://doi.org/10.1016/S0378-8741(97)01510-9 ]

Dermatotoxicology (reviews)

Evans F J and Schmidt R J — Plants and plant products that induce contact dermatitis, Planta Medica 38(4): 289-316 (1980) [ ISSN 0032-0943 : https://doi.org/10.1055/s-2008-1074883 ]

Schmidt R J — The super-nettles: a dermatologist's guide to ants in the plants, International Journal of Dermatology 24(4): 204-210 (1985) [ ISSN 0011-9059 : https://doi.org/10.1111/j.1365-4362.1985.tb05760.x ]

Schmidt R J — Compositae, Clinics in Dermatology 4(2): 46-61 (1986) [ ISSN 0738-081X : https://doi.org/ 10.1016/0738-081X(86)90063-5 ]

Schmidt R J — Cutaneous side effects in transdermal drug delivery: avoidance strategies, Transdermal Drug Delivery (Editors Hadgraft J and Guy R H). Marcel Dekker, New York : 83-97 (1989) [ ISBN 0-8247-7991-6 : http:// www.worldcat.org/oclc/18441987 ]

Schmidt R J — Plants, Occupational Skin Disease 2nd edn (Editor Adams R M). W B Saunders, Philadelphia : 503-524 (1990) [ ISBN 0-7216-2926-1 : http://www.worldcat.org/oclc/19922774 ]

Ducombs G and Schmidt R J — Plants and plant products, Textbook of Contact Dermatitis (Editors Rycroft R J G, Menné T, Frosch P and Benezra C). Springer-Verlag, Heidelberg : 588-634 (1992) [ ISBN 3-540-54562-X : http:// www.worldcat.org/oclc/611387372 ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !9 of 18! Schmidt R J, Chung L Y and Hadgraft J — New perspectives on prohapten activation in the pre-immunologic phase of allergic contact dermatitis, Prediction of Percutaneous Penetration Vol 3b, (Editors Brain K R, James V J and Walters K A). STS Publishing, Cardiff : 670-678 (1993) [ ISBN 0-948917-06-7 : http://www.worldcat.org/oclc/77672351 ]

Ducombs G and Schmidt R J — Plants and plant products, Textbook of Contact Dermatitis, 2nd edn (Editors Rycroft R J G, Menné T, Frosch P). Springer-Verlag, Heidelberg : 588-634 (1995) [ ISBN 3-540-57943-5 : http:// www.worldcat.org/oclc/456497808 ]

Schmidt R J — Allergic contact dermatitis to liverworts, lichens, and mosses, Seminars in Dermatology 15(2): 95-102 (1996) [ ISSN 0278-145X : https://www.ncbi.nlm.nih.gov/pubmed/8840404 ]

Schmidt R J — Forestry workers, Handbook of Occupational Dermatology (Editors Kanerva L, Elsner P, Wahlberg J E, Maibach H I). Springer-Verlag, Heidelberg : 938-944 (2000) [ ISBN 3-540-64046-0 : http://www.worldcat.org/oclc/ 610681996 ]

Ducombs G and Schmidt R J — Plants and plant products, Textbook of Contact Dermatitis, 3rd edn (Editors Rycroft R J G, Menné T, Frosch P J, Lepoittevin J -P). Springer-Verlag, Heidelberg : 883-931 (2001) [ ISBN 3-540-66842-X : http://www.worldcat.org/oclc/44818410 ]

Calapai G, Miroddi M, Minciullo P L, Caputi A P, Gangemi S and Schmidt R J — Contact dermatitis as an adverse reaction to some topically-used European herbal medicinal products – part 1: Achillea millefolium–Curcuma longa, Contact Dermatitis 71(1): 1-12 (2014) [ ISSN 0105-1873 : https://doi.org/10.1111/cod.12222]

Gangemi S, Minciullo P L, Miroddi M, Chinou I, Calapai G and Schmidt R J — Contact dermatitis as an adverse reaction to some topically-used European herbal medicinal products – Part 2: Echinacea purpurea–Lavandula angustifolia, Contact Dermatitis 72(4): 193-205 (2015) [ ISSN 0105-1873 : https://doi.org/10.1111/cod.12328]

Calapai G, Minciullo P L, Miroddi M, Chinou I, Gangemi S and Schmidt R J — Contact dermatitis as an adverse reaction to some topically-used European herbal medicinal products – Part 3: x piperita – Solanum dulcamara, Contact Dermatitis 74(3): 131-144 (2016) [ ISSN 0105-1873 : https://doi.org/10.1111/cod.12483]

Minciullo P L, Calapai G, Miroddi M, Mannucci, C, Chinou I, Gangemi S and Schmidt R J — Contact dermatitis as an adverse reaction to some topically-used European herbal medicinal products – Part 4: Solidago virgaurea – Vitis vinifera, Contact Dermatitis 77(2): 67-87 (2017) [ ISSN 0105-1873 : https://doi.org/10.1111/cod.12807]

Schmidt R J — Regulation (EC) No 1223/2009 – a recast of the Cosmetic Products Directive 76/768/EEC - in regard to the safety of plant-derived cosmetic product ingredients, The Expert Witness 1(20): 35-37 (2017) [ ISSN 2397– 2769 : http://www.expertwitnessjournal.co.uk/more/past-issues/904-issue-20]

Dermatotoxicology (reports)

Schmidt R J — In vitro hair dye allergenicity testing. Clairol Inc., Stamford, Connecticut, USA (1994) Research Report

Schmidt R J — In vitro hair dye allergenicity testing. Clairol Inc., Stamford, Connecticut, USA (1995) Research Report

Schmidt R J — In vitro hair dye allergenicity testing. Clairol Inc., Stamford, Connecticut, USA (1996) Research Report

Dermatotoxicology (abstracts, posters, letters)

Schmidt R J and Evans F J — Structure and potency of some ‘Tinya’ toxins, Journal of Pharmacy and Pharmacology 27(Suppl): 50P (1975) [ ISSN 0022-3573 ]

Schmidt R J — Parthenium indicum, Pharmaceutical Journal 218(5912): 230 (1977) [ ISSN 0031-6873 ]

Schmidt R J and Evans F J — Production of inflammation by diterpene esters, Journal of Pharmacy and Pharmacology 29(Suppl): 18P (1977) [ ISSN 0022-3573 : https://doi.org/10.1111/j.2042-7158.1977.tb11486.x ]

Schmidt R J — Those bulb rashes, Garden News (1066 Dec. 9th): 5 (1978) [ ISSN 0016-4593 ]

Schmidt R J — What is the toxic substance that gives the crab apple like fruit of the tropical manchineel tree its poisonous property? British Medical Journal 289(6439): 239 (1984) [ ISSN 0007-1447 : https://doi.org/10.1136/bmj. 289.6439.238 ]

Schmidt R J and Fernández de Corres L — Allergic contact dermatitis from proprietary topical analgesic sprays containing 3-(aminomethyl)-pyridyl salicylate, 8th International Symposium on Contact Dermatitis, Cambridge : 083 (1986)

Schmidt R J and Fernández de Corres L — Dermatitis y urticaria de contacto por sprays analgésicos conteniedo 3- aminometil-piridil-salicilato, Revista Española de Alergologia e Inmunologia Clinica 1: 160 (1986) [ ISSN 0214-1477 ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p 10! of 18! Schmidt R J and Khan L — The induction of metabolic activity in mouse skin by prohaptens, 7th Workshop, European Research Group on Experimental Contact Dermatitis, Basel (1986)

Schmidt R J and Chung L Y — Evidence that urushiols are not prohaptens but haptens; the significance of skin glutathione, 8th Workshop, European Research Group on Experimental Contact Dermatitis, Heidelberg (1988)

Chung L Y and Schmidt R J — Is sesquiterpene lactone contact allergy the outcome of a Michael addition to skin protein? 9th Workshop, European Research Group on Experimental Contact Dermatitis, Malmö (1989)

Schmidt R J and Chung L Y — Landsteiner and Jacobs (1936) revisited, 9th Workshop, European Research Group on Experimental Contact Dermatitis, Malmö (1989)

Schmidt R J and Chung L Y — Oxidative stress occurs in skin in the pre-immunologic phase of the cell-mediated immune response to allergenic 2,4-dinitrohalobenzenes, Free Radicals in Biology and Medicine 9(Suppl 1): 147 (1990) [ ISSN 0891-5849 : https://doi.org/10.1016/0891-5849(90)90699-J ]

Schmidt R J — Are we now in a better position to better understand the phenomenon of angry back and false positive reactions? 10th Meeting of the European Research Group on Experimental Contact Dermatitis, London (1991)

Schmidt R J — Don't be complacent! Garden News (1711 April 10-16th): 5 (1991) [ ISSN 0016-4593 ]

Schmidt R J, Chung L Y, Basketter D A, Barratt M D, Sharma R and Scholes E — Further prohapten activation studies on and congeners, 11th Meeting of the European Research Group on Experimental Contact Dermatitis, Amsterdam (1992)

Schmidt R J — Oxidative stress in the induction of irritant and allergic contact dermatitis, in relation to plant products, Symposium on Plant Dermatology, Odense : 2-3 (1993)

Schmidt R J, Chung L Y and Hadgraft J — New perspectives on prohapten activation in the pre-immunologic phase of allergic contact dermatitis, Prediction of Percutaneous Penetration Vol 3a (Editors Brain K R, Hadgraft J, James V J and Walters K A). STS Publishing, Cardiff : C85 (1993) [ ISBN 0-948917-04-0 : http://www.worldcat.org/oclc/ 43232333 ]

Schmidt R J — Tosyl chloride, Contact Dermatitis 32(2): 124 (1995) [ ISSN 0105-1873 : https://doi.org/10.1111/j. 1600-0536.1995.tb00773.x ]

Schmidt R J and Read D C — An electrochemical approach to the study of prohapten activation: a possible nitroreductase model, Prediction of Percutaneous Penetration Vol 4a (Editors Brain K R, James V J and Walters K A). STS Publishing, Cardiff : C82 (1995) [ ISBN 0-948917-09-1 : http://www.worldcat.org/oclc/85100990 ]

Schmidt R J, Hadgraft J and Jones H L — The development of a new database of chemical and physico-chemical parameters for predicting contact allergenic potential of new chemical entities, Prediction of Percutaneous Penetration Vol 4a (Editors Brain K R, James V J and Walters K A). STS Publishing, Cardiff : C83 (1995) [ ISBN 0-948917-09-1 : http://www.worldcat.org/oclc/85100990 ]

Schmidt R J, Hadgraft J, Jones H L — The development of a new database of chemical and physico-chemical parameters for predicting contact allergenic potential of new chemical entities, 13th Meeting of the European Research Group on Experimental Contact Dermatitis, Strasbourg (1995)

Schmidt R J, Read D C — An electrochemical approach to the study of prohapten activation: a possible nitroreductase model, 13th Meeting of the European Research Group on Experimental Contact Dermatitis, Strasbourg (1995)

Schmidt R J — Redox processes and prohapten activation in skin, 3rd Düsseldorf Symposium on Immunotoxicology: T Cell Reactions to Drugs and their Metabolites, Abstracts, Düsseldorf : 46 (1996)

Schmidt R J, Jones H J and Read D C — Refining the antioxidant hypothesis of prohapten activation. A possible role for iron in the activation of para-phenylenediamine, Prediction of Percutaneous Penetration Vol 5a (Editors Brain K R, James V J and Walters K A). STS Publishing, Cardiff : 116 (1997) [ ISBN 0-948917-11-3 : http://www.worldcat.org/ oclc/41062217 ]

Schmidt R J — The Botanical Dermatology Database (http://BoDD.cf.ac.uk) : an electronic reincarnation of Mitchell & Rook's Botanical Dermatology, American Journal of Contact Dermatitis 12(1): 40-42 (2001) [ ISSN 1046-199X : https://doi.org/10.1053/ajcd.2000.8938 ]

Schmidt R J — Free radicals and the antioxidant hypothesis of prohapten activation, Contact Dermatitis 56(1): 65-67 (2007) [ ISSN 0105-1873 : https://doi.org/10.1111/j.1600-0536.2007.01146.x ]

Schmidt R J —The importance of establishing correct botanical identity, Contact Dermatitis 63(Suppl. 1): 19 (2010) [ ISSN 0105-1873 : https://doi.org/10.1111/j.1600-0536.2010.01793.x ]

Schmidt R J — Online response to Davies E — A sensitive subject, Chemistry World 9(10): 42-45 (2012) [ ISSN 1473-7604 : https://www.chemistryworld.com/feature/a-sensitive-subject/5469.article ; https://www.researchgate.net/ publication/256375309_Online_response_to_Davies_E__A_sensitive_subject ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p !11 of 18! Schmidt R J — Regulation (EC) No. 1223/2009, a recast of the Cosmetic Products Directive 76/768/EEC, in relation to the safety of plant-derived cosmetic product ingredients, Contact Dermatitis 75(Suppl. 1): 19 (2016) [ ISSN 0105-1873 : https://doi.org/10.1111/cod.12634 ]

Biomaterials (full papers)

Schmidt R J, Shrestha T and Turner T D — An assay procedure to compare sorptive capacities of activated carbon dressings: the detection of impregnation with silver, Journal of Pharmacy and Pharmacology 40(9): 662-664 (1988) [ ISSN 0022-3573 : https://doi.org/10.1111/j.2042-7158.1988.tb05334.x ]

Turner T D, Spyratou O and Schmidt R J — Biocompatibility of wound management products: standardization of and determination of cell growth rate in L929 fibroblast cultures, Journal of Pharmacy and Pharmacology 41(11): 775-780 (1989) [ ISSN 0022-3573 : https://doi.org/10.1111/j.2042-7158.1989.tb06364.x ]

Schmidt R J, Spyratou O and Turner T D — Biocompatibility of wound management products: the effect of various monosaccharides on L929 and 2002 fibroblast cells in culture, Journal of Pharmacy and Pharmacology 41(11): 781-784 (1989) [ ISSN 0022-3573 : https://doi.org/10.1111/j.2042-7158.1989.tb06365.x ]

Schmidt R J, Chung L Y, Andrews A M and Turner T D — is a murine (L929) fibroblast cell proliferant at micro- to nanomolar concentrations, Proceedings of the 1st European Conference on Advances in Wound Management (Editors Harding K G, Leaper D L and Turner T D). Macmillan Magazines, London : 117-120 (1992) [ ISBN 0-333-58645-X ]

Chung L Y, Andrews A M, Schmidt R J and Turner T D — Effects of minoxidil on cell proliferation and intracellular glutathione status of murine (L929) fibroblasts, Proceedings of the 1st European Conference on Advances in Wound Management (Editors Harding K G, Leaper D L and Turner T D). Macmillan Magazines, London : 122-128 (1992) [ ISBN 0-333-58645-X ]

Chung L Y, Schmidt R J, Andrews A M and Turner T D — A study of hydrogen peroxide generation by, and antioxidant activity of, Granuflex™ (DuoDERM™) Hydrocolloid Granules and some other hydrogel/hydrocolloid wound management materials, British Journal of Dermatology 129(2): 145-153 (1993) [ ISSN 0007-0963 : https://doi.org/ 10.1111/j.1365-2133.1993.tb03517.x ]

Schmidt R J, Chung L Y and Turner T D — Quantification of hydrogen peroxide generation by Granuflex™ (DuoDERM™) Hydrocolloid Granules and its constituents (gelatin, sodium carboxymethylcellulose, and pectin), British Journal of Dermatology 129(2): 154-157 (1993) [ ISSN 0007-0963 : https://doi.org/10.1111/j. 1365-2133.1993.tb03518.x ]

Chung L Y, Schmidt R J, Andrews A M and Turner T D — Modulation of the rate of proliferation of murine L929 fibroblasts by a chitosan/plasma membrane interaction and by hydrogen peroxide formed by auto-oxidation of chitin/ chitosan in cell culture medium, Proceedings of the 2nd European Conference on Advances in Wound Management (Editors Harding K G, Cherry G, Dealey C and Turner T D). Macmillan Magazines, London : 144-149 (1993) [ ISBN 0-333-60149-1 ]

Chung L Y, Schmidt R J, Andrews A M and Turner T D — Immunomodulating activity of chitosan on murine peritoneal macrophages appears to be mediated by auto-oxidatively derived hydrogen peroxide, Proceedings of the 2nd European Conference on Advances in Wound Management (Editors Harding K G, Cherry G, Dealey C and Turner T D). Macmillan Magazines, London : 149-153 (1993) [ ISBN 0-333-60149-1 ]

Schmidt R J, Chung L Y, Andrews A M, Spyratou O and Turner T D — Biocompatibility of wound management products: a study of the effects of various polysaccharides on murine L929 fibroblast proliferation and macrophage respiratory burst, Journal of Pharmacy and Pharmacology 45(6): 508-513 (1993) [ ISSN 0022-3573 : https://doi.org/ 10.1111/j.2042-7158.1993.tb05589.x ]

Schmidt R J, Chung L Y, Andrews A M and Turner T D — Toxicity of L-ascorbic acid to L929 fibroblast cultures: relevance to biocompatibility testing of materials for use in wound management, Journal of Biomedical Materials Research 27(4): 521-530 (1993) [ ISSN 0021-9304 : https://doi.org/10.1002/jbm.820270413 ]

Chung L Y, Schmidt R J, Hamlyn P F, Sagar B F, Andrews A M and Turner T D — Biocompatibility of potential wound management products: fungal mycelia as a source of chitin/chitosan and their effect on the proliferation of human F1000 fibroblasts in culture, Journal of Biomedical Materials Research 28(4): 463-469 (1994) [ ISSN 0021-9304 : https://doi.org/10.1002/jbm.820280409 ]

Schmidt R J, Chung L Y, Andrews A M, Sagar B F, Hamlyn P F and Turner T D — Hydrogen peroxide generation by chitins/chitosans of fungal origin and its relationship to their pro- and anti-proliferative effects on fibroblasts in culture, Proceedings of the 3rd European Conference on Advances in Wound Management (Editors Harding K G, Dealey C, Cherry G and Gottrup F). Macmillan Magazines Ltd., London : 80-81 (1994) [ ISBN 0-333-62737-7 : http:// www.worldcat.org/oclc/84992088 ]

Schmidt R J, Kirby, A J and Chung L Y — Cadexomer iodine formulations may modulate the redox environment of wounds, Iodine and Wound Physiology. Proceedings of a Symposium held during the 5th Annual Meeting of the European Tissue Repair Society. Information Transfer, London : 6.1-6.26 (1995) [ ISBN 1-900337-00-2 : http:// www.worldcat.org/oclc/35785368 ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p 12! of 18! Chung L Y, Schmidt R J, Hamlyn P F, Sagar B F, Andrews A M and Turner T D — Biocompatibility of potential wound management products: hydrogen peroxide generation by fungal chitin/chitosans and their effects on the proliferation of murine L929 fibroblasts in culture, Journal of Biomedical Materials Research 39(2): 300-307 (1998) [ ISSN 0021-9304 : https://doi.org/10.1002/(SICI)1097-4636(199802)39:2<300::AID-JBM18>3.0.CO;2-G ]

Cullen B, Watt P W, Lundqvist C, Silcock D, Schmidt R J, Bogan D and Light N D — The role of oxidised regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action, International Journal of Biochemistry and Cell Biology 34(12): 1544-1556 (2002) [ ISSN 1357-2725 : https://doi.org/10.1016/S1357-2725(02)00054-7 ]

Biomaterials (reviews)

Schmidt R J — Xerogel dressings an overview, Advances in Wound Management (Editors Turner T D, Schmidt R J and Harding K G). John Wiley & Sons, Chichester : 65-71 (1986) [ ISBN 0-471-91312-X : http://www.worldcat.org/ oclc/497252409 ]

Schmidt R J — Hydrogels, hydrocolloids, xerogels and xerocolloids, Wound Management Conference, London. Medical and Clinical Research Consultants, Romford, Essex : 23-29 (1988)

Schmidt R J — Alginates in wound management, First Advanced Course on Alginates and their Applications, Trondheim : 88-90 (1991)

Schmidt R J — The biochemistry and clinical use of hydrogels and polysaccharide dressings, An Introduction to Wound Management, London. Rostrum, Romford, Essex : 36-45 (1992)

Hamlyn P F and Schmidt R J — Potential therapeutic application of fungal filaments in wound management, Mycologist 8(4): 147-152 (1994) [ ISSN 0269-915X : https://doi.org/10.1016/S0269-915X(09)80176-6 and http:// fungus.org.uk/nwfg/woundnw.htm ]

Schmidt R J — Redox homeostasis and microbial colonisation of wounds: new insights into the energy economy of chronic wounds, Journal für Anästhesie und Intensivbehandlung 3(3): 26-31 (1996) [ ISSN 0941-4223 : http:// www.pabst-publishers.de/Medizin/med Zeitschriften/jai/1996-3/art-6.html ; downloadable from http://bit.ly/VQBqm4 ]

Schmidt R J, Biggs M — Modulation of the redox environment of chronic wounds. Practical and regulatory issues, Proceedings of the European Wound Management Association / Journal of Wound Care Spring Meeting, Milan (Editors Leaper D, Cherry G, Cockbill S, Dealey C, Flanagan M, Hofman D, Jones V, and Turner T D) Macmillan Magazines, London : 78-80 (1998) [ ISBN 0-333-746-02-3 : http://www.worldcat.org/oclc/45054921]

Biomaterials (reports)

Fowler M, Lowe A, Schmidt R J, Turner T D, Burrow T R, Falshaw A, Spyratou O and Laity P R — An investigation of polymer materials of potential value in wound management 1987-1989. Courtaulds Research, Coventry (1990) Internal report (restricted circulation) on SERC/Courtaulds project

Turner T D, Schmidt R J and Chung L Y — Effect of fungal chitin samples (J, K, L, M, N & P) on L929 fibroblast cultures. BTTG, Manchester, UK (1991) Confidential Report

Chung L Y and Schmidt R J — Antioxidant (DPPH) and pro-oxidant (H2O2) properties of some chitin / chitosan samples. Protan Ltd., Alton, Hampshire, UK (1993) Research Report

Fowler M, Burrow T R, Schmidt R J, Chung L Y, Andrews A M and Turner T D — An investigation of polymer materials of potential value in wound management 1989-1991. Courtaulds Research, Coventry (1993) Internal report (restricted circulation) on SERC/Courtaulds project

Chung L Y and Schmidt R J — The pro-oxidant / antioxidant profiles of Iodosorb powder, cadexomer powder, iodine, and Debrisan beads, and their effects on murine (L929) fibroblast proliferation and on murine peritoneal macrophage oxidative burst. Perstorp Pharma Ltd, Basingstoke, UK (1994) Research Report

Schmidt R J and Biggs J M — KSol™ technology. National Endowment for Science, Technology and the Arts (2002) Research Report

Biomaterials (abstracts, posters, letters)

Schmidt R J and Turner T D — Calcium alginate dressings, Pharmaceutical Journal 236(6379): 578 (1986) [ ISSN 0031-6873 ]

Schmidt R J, Turner T D and Spyratou O — Alginate dressings, Pharmaceutical Journal 237(6388): 36-37 (1986) [ ISSN 0031-6873 ]

Schmidt R J — The biochemistry of gels and colloids, Wound Management in the Hospital and the Community Conference, London. Medical and Clinical Research Consultants, Romford, Essex (1989)

Turner T D and Schmidt R J — The tissue culture assay of wound management material biocompatibility, Society for Tissue Viability, Spring Conference, Cardiff (1989)

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p 13! of 18! Schmidt R J, Chung L Y, Andrews A M and Turner T D — The toxicity of L-ascorbic acid to L929 mouse fibroblast cultures, Journal of Pharmacy and Pharmacology 42(Suppl): 31P (1990) [ ISSN 0022-3573 : https://doi.org/10.1111/ j.2042-7158.1990.tb14404.x ]

Schmidt R J, Chung L Y, Andrews A M and Turner T D — Hydrogen peroxide is a murine (L929) fibroblast cell proliferant at micro- to nanomolar concentrations, 1st European Conference on Advances in Wound Management, Cardiff. Macmillan Conferences, London : 27-28 (1991)

Chung L Y, Andrews A M, Schmidt R J and Turner T D — Effects of minoxidil on murine (L929) fibroblasts: cell proliferation, intracellular glutathione status, and scavenging of reactive oxygen species, 1st European Conference on Advances in Wound Management, Cardiff. Macmillan Conferences, London : 28 (1991)

Chung L Y, Schmidt R J, Andrews A M and Turner T D — Immunomodulating activity of chitosan on murine peritoneal macrophages appears to be mediated by auto-oxidatively-derived hydrogen peroxide, 2nd European Conference on Advances in Wound Management, Cardiff. Macmillan Conferences, London : 27 (1992)

Chung L Y, Schmidt R J, Andrews A M and Turner T D — Modulation of the rate of proliferation of L929 fibroblasts by a chitosan/plasma membrane interaction and by hydrogen peroxide formed by the auto-oxidation of chitin/chitosan in cell culture medium, 2nd European Conference on Advances in Wound Management, Cardiff. Macmillan Conferences, London : 27 (1992)

Schmidt R J, Chung L Y, Andrews A M and Turner T D — A study of hydrogen peroxide generation by and anti-oxidant activity of Granuflex™ (DuoDERM™) hydrocolloid granules and some other hydrogel/hydrocolloid wound management materials, 2nd European Conference on Advances in Wound Management, Cardiff. Macmillan Conferences, London : 4 (1992)

Schmidt R J — Redox homeostasis and bacterial colonisation of healing wounds, Joint Meeting of the Wound Healing Society / European Tissue Repair Society, Amsterdam : 9 (1993)

Schmidt R J, Chung L Y, Andrews A M and Turner T D — A study of hydrogen peroxide generation by and anti-oxidant activity of Granuflex™ (DuoDERM™) hydrocolloid granules, its constituents and some other hydrogel/hydrocolloid wound management materials, Proceedings of the 2nd European Conference on Advances in Wound Management (Editors Harding K G, Cherry G, Dealey C and Turner T D). Macmillan Magazines, London : 17 (1993) [ ISBN 0-333-60149-1 ]

Schmidt R J, Chung L Y, Andrews A M, Turner T D, Sagar B F and Hamlyn P F — Hydrogen peroxide generation by chitin/chitosans of fungal origin and its relationship to their pro- and anti-proliferative effects on fibroblasts in culture, 3rd European Conference on Advances in Wound Management, Harrogate. Macmillan Magazines, London : 14 (1993)

Schmidt R J and Chung L Y — A comparison of pro-oxidant / antioxidant profiles of Debrisan™ beads and Iodosorb™ powder, 4th Annual Meeting of the European Tissue Repair Society, Programme and Abstracts, Oxford: 128 (1994)

Chung L Y and Schmidt R J — Effects of Debrisan™ beads and Iodosorb™ powder on L929 fibroblast proliferation and mouse macrophage respiratory burst, 4th Annual Meeting of the European Tissue Repair Society, Programme and Abstracts, Oxford: 129 (1994)

Schmidt R J, Kirby A J and Chung L Y — Cadexomer iodine formulations may modulate the redox environment of wounds, 5th Annual Meeting of the European Tissue Repair Society, Programme and Abstracts, Padova : 94 (1995)

Chung L Y and Schmidt R J — Modulation of macrophage respiratory burst and fibroblast proliferation by chitin/ chitosan, Asian Journal of Pharmacy : A-20 (1996) [ ISSN 0066-8419 : http://www.worldcat.org/oclc/2040132 ]

Schmidt R J and Biggs J M — Modulation of the redox environment of chronic wounds. Practical and regulatory issues, European Wound Management Association Spring Meeting, Programme, Milan : 17 (1997)

Schmidt R J and Biggs J M — New approaches to the management of chronic wounds, Wounds 9(2): 63 (1997) [ ISSN 1044-7946 ]

Bogan D P and Schmidt R J — Applications of HPLC to biomaterials in the Wound Care Research Group, Joint CAIS / Johnson & Johnson Chromatography Symposium, Princeton, New Jersey (1998)

Schmidt R J, Bogan D, Moore J and Gray G — A chaotic approach to the design of dressings to increase the healing rate of chronic ulcers, 6th Johnson & Johnson Worldwide Skin Care Symposium, New Brunswick, New Jersey : Poster #110 (1999)

Patents

Fowler M J, Burrow T J, Turner T D, Schmidt R J and Chung L Y — Polymers carrying free radical groups and precursors thereof for wound dressing GB 2288736 [Granted 02 Oct 1996] WO 9413333 A1 published 23 Jun 1994 AU 679954 B2 [Accepted 17 Jul 1997] US 5667501 [Issued 16 Sep 1997] EP 0673262 B1 [Granted 05 Apr 2000] CA 2151246 C

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p 14! of 18! Schmidt R J and Chung L Y — Treatment of allergic contact dermatitis GB 2267437 [Granted 22 Jan 1997] US 5578300 [Issued 26 Nov 1996]

Schmidt R J — Biological wound dressings comprising mitochondria GB 2350565 A filed 28 May 1999

Schmidt R J, Bogan D, Moore J — Solid compositions exhibiting selective binding to dissolved iron AU 782756 B2 [Accepted 25 Aug 2005] EP 1153620 A3, filed 11 May 2001 US 2003/078209 CA 2347566 JP 200220402

Schmidt R J — Modified polysaccharides containing thiol groups; Therapeutic compositions comprising modified polysaccharides EP 1487508 B1 [Granted 10 May 2006] GB 2386900 B WO 03080135 filed 24 Mar 2003 AU 2003212539

Schmidt R J, Bogan D, Moore J — Use of oxidized cellulose as free radical scavenger AU 200143804 B2 [Accepted 11 May 2006] EP 1153618 filed 11 May 2001 CA 2347442 JP 2001354571

Schmidt R J — Chemically modified polysaccharides comprising grafted side chains with two or more carboxylate groups EP 1487507 B1 [Granted 12 Jul 2006] GB 2386899 filed 25 Mar 2002 WO 03080134 filed 24 Mar 2003 AU 2003212538

Schmidt R J and Biggs J M — Saline solutions for clinical use UK patent application no. GB 0123115.8; filed 26 Sep 2001 EP 1429790 A2 WO 03026679 A3 filed 26 Sep 2002 US 8,236,863 B2 [Issued 07 August 2012 : http://www.uspto.gov/web/patents/patog/week32/OG/html/1381-1/ US08236863-20120807.html ]

Schmidt R J and Biggs J M — Saline preparations for clinical use UK patent application no. GB 0417544.4; filed 06 Aug 2004

Miscellaneous publications (full papers)

Zhao Y, Wang J L, Wu X P, Williams F W and Schmidt R J — Point-wise and whole-field laser speckle intensity fluctuation measurements applied to botanical specimens, Optics and Lasers in Engineering 28(6): 443-456 (1997) [ ISSN 0143-8166 : https://doi.org/10.1016/S0143-8166(97)00056-0 ]

Miscellaneous publications (reviews)

Schmidt R J Drugs from the sea, Times Atlas of the Oceans (Editor Couper A D). Times Books Ltd, London : 119 (1983) [ ISBN 0-7230-0246-0 : http://www.worldcat.org/oclc/802591569 ]

Schmidt R J — Biosynthetic and chemosystematic aspects of the and Thymelaeaceae, Naturally Occurring (Editor Evans F J). CRC Press, Boca Raton, Florida : 87-106 (1986) [ ISBN 0-8493-5117-0 : http://www.worldcat.org/oclc/12724198 ]

Schmidt R J — The daphnane polyol esters, Naturally Occurring Phorbol Esters (Editor Evans F J). CRC Press, Boca Raton, Florida : 217-243 (1986) [ ISBN 0-8493-5117-0 : http://www.worldcat.org/oclc/12724198 ]

Schmidt R J — The ingenane polyol esters, Naturally Occurring Phorbol Esters (Editor Evans F J). CRC Press, Boca Raton, Florida : 245-269 (1986) [ ISBN 0-8493-5117-0 : http://www.worldcat.org/oclc/12724198 ]

Schmidt R J — The biosynthesis of tiglianes and related diterpenoids; an intriguing problem, Botanical Journal of the Linnean Society 94(1/2): 221-230 (1987) [ ISSN 0024-4074 : https://doi.org/10.1111/j.1095-8339.1987.tb01047.x ]

Schmidt R J — , Pharmaceutical Journal 251(6749): 150 (1993) [ ISSN 0031-6873 ]

Schmidt R J, Broadley K J and Nicholls P J — Oxidative stress and lung toxicology, Cotton Dust. Proceedings of the 17th Cotton Dust Research Conference (Editors Domelsmith L N, Jacobs R R and Wakelyn P J). National Cotton Council of America, Memphis, Tennessee : 240-244 (1993) [ ISSN 0897-5531 : http://www.worldcat.org/oclc/ 17561748 ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p 15! of 18! Schmidt R J — Paracetamol: its dark side, NAWP Magazine (08): 10-13 (2013) [ http://www.nawp.org.uk/pdf/P217- V4-NAWP_Magazine_PL.pdf ]

Miscellaneous publications (abstracts, posters, letters)

Schmidt R J — Is dry of value in preventing travel sickness? British Medical Journal 289(6446): 680 (1984) [ ISSN 0007-1447 ]

Schmidt R J — Oral and topical preparations of the medicinal plant Aloe vera are sold in Australia with the claim that they have great therapeutic value. Is there any truth in this? British Medical Journal 290(6486): 1974 (1985) [ ISSN 0007-1447 ]

Schmidt R J — What is known of the South American Andes cocona fruit used in native medicine for the treatment of diabetes, apparently over a wide area ranging from Peru to Argentina? British Medical Journal 292(6532): 1379 (1986) [ ISSN 0007-1447 ]

Schmidt R J — Pharmacog for ever! Pharmaceutical Journal 242(6538): 700 (1989) [ ISSN 0031-6873 ]

Schmidt R J — Civil liability and patient safety, Pharmaceutical Journal 248(6679): 374 (1992) [ ISSN 0031-6873 ]

Schmidt R J — Civil liability and patient safety, Pharmaceutical Journal 248(6689): 696 (1992) [ ISSN 0031-6873 ]

Schmidt R J — Dietary supplements, Pharmaceutical Journal 251(6751): 208 (1993) [ ISSN 0031-6873 ]

Schmidt R J, Broadley K J and Nicholls P J — Oxidative stress and lung toxicology, 17th Cotton Dust Research Conference, New Orleans : 1 (1993)

Schmidt R J — Ketoconazole, Pharmaceutical Journal 258(6928): 169 (1997) [ ISSN 0031-6873 ]

Schmidt R J — A turning point? Pharmaceutical Journal 264(7083): 258 (2000) [ ISSN 0031-6873 : http:// www.pharmaceutical-journal.com/a-turning-point/20000470.article ]

Schmidt R J — No surprises, Pharmaceutical Journal 264(7096): 726 (2000) [ ISSN 0031-6873 : http:// www.pharmaceutical-journal.com/no-surprises/20001462.article ]

Schmidt R J — Detergent risk to gut? Pharmaceutical Journal 265(7119): 601 (2000) [ ISSN 0031-6873 : http:// www.pharmaceutical-journal.com/detergent-risk-to-the-gut/20003329.article ]

Schmidt R J — Evidence-based or commercial hype? Pharmaceutical Journal 266(7139): 356-357 (2001) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-letters/20004132.article#flax ]

Schmidt R J — More pharmacists, not delegation, is the key to the future of pharmacy, Pharmaceutical Journal 267(7164): 320 (2001) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-more-pharmacists-not- delegation-is-the-key-to-the-future-of-pharmacy/20004930.article ]

Schmidt R J — An alternative view of the future of the community pharmacy, Pharmaceutical Journal 267(7166): 380 (2001) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-broad-spectrum/20005024.article ]

Schmidt R J — Should nurses prescribe generically? Pharmaceutical Journal 269(7227): 812-813 (2002) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-pj-letters-drug-tariff/20008313.article ]

Schmidt R J — Generic specifications for standard products needed, Pharmaceutical Journal 270(7233): 116-117 (2003) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-pj-letters-appliances-and-devices/ 20008640.article ]

Schmidt R J — Same laws of science apply to all medical practices - if only people realised that, Pharmaceutical Journal 270(7241): 398 (2003) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-broad-spectrum/ 20009049.article ]

Schmidt R J — Food for thought, Chemistry in Britain 39(4): 19-20 (2003) [ ISSN 0009-3106 ]

Schmidt R J — Homoeopathy. Another example of muddled thinking? Pharmaceutical Journal 270(7247): 618 (2003) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-pj-letters-homoeopathy/20009344.article - 5 ]

Schmidt R J — Is it time for St John's Wort to become a pharmacy medicine? Pharmaceutical Journal 272(7292): 381 (2004) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-pj-letters-st-johns-wort/ 20011505.article ]

Schmidt R J — How are drug names decided? Pharmaceutical Journal 272(7295): 472 (2004) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-pj-letters-drug-nomenclature/20011668.article ]

Schmidt R J — St John's Wort. Was meta-analysis meaningful? Pharmaceutical Journal 273(7307): 52 (2004) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/pj-online-pj-letters-st-johns-wort/20012295.article ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p 16! of 18! Schmidt R J — The relationship between SOPs and PI insurance, Pharmaceutical Journal 274(7343): 390-391 (2005) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/the-relationship-between- sops-and-pi-insurance/10019439.article ]

Schmidt R J — Maybe the homoeopath, not the medicine, is the healer, Pharmaceutical Journal 275(7367): 336 (2005) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/maybe-the-homoeopath- not-the-medicine-is-the-healer/10020777.article ]

Schmidt R J — Is distilled witch hazel just water and alcohol? Pharmaceutical Journal 276(7383): 39 (2006) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/is-distilled-witch-hazel-just-water-and- alcohol/10020595.article ]

Schmidt R J — Can nurses prescribe diazepam 5mg/5ml oral solutions? Pharmaceutical Journal 276(7384): 72 (2006) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/can-nurses-prescribe- diazepam-5mg/5ml-oral-solutions/10020693.article ]

Schmidt R J — Standard operating procedures and self-employed status, Pharmaceutical Journal 276(7389): 232 (2006) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/news-and-analysis/news/standard-operating- procedures-and-self-employed-status/10021077.article ]

Schmidt R J — Fish oil supplements are not fish: rapid response to Hooper L et al., British Medical Journal online publication: http://dx.doi.org/10.1136/bmj.38755.366331.2F (2006) [ ISSN 1468-5833 : http://www.bmj.com/rapid- response/2011/10/31/fish-oil-supplements-are-not-fish ]

Schmidt R J — Practitioner-augmented placebo effect, Pharmaceutical Journal 276(7406): 747 (2006) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/practitioner-augmented-placebo-effect/ 10022178.article ]

Schmidt R J — Built on unsound foundation, Pharmaceutical Journal 277(7414): 220-221 (2006) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/built-on-an-unsound-foundation/10001895.article ]

Schmidt R J — Showing homoeopaths the way forward, Pharmaceutical Journal 277(7418): 334-335 (2006) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/showing-homoeopaths-the-way-forward/ 10002086.article ]

Schmidt R J — Watery solution to amino acid question? Chemistry World 4(1): 32 (2007) [ ISSN 1473-7604 : http:// www.rsc.org/chemistryworld/restricted/2007/january/letters.asp ]

Schmidt R J — Job description of the locum pharmacist is set to change, Pharmaceutical Journal 279(7473): 401 (2007) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/job-description-of-the- locum-pharmacist-is-set-to-change/10005117.article ]

Schmidt R J — Muddled thinking over future statutory responsibilities, Pharmaceutical Journal 279(7478): 563 (2007) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/muddled-thinking-over-future- statutory-responsibilities/10005381.article ]

Schmidt R J — Bring an end to the 400 MURs target, Pharmaceutical Journal 282(7545): 339 (2009) [ ISSN 0031-6873 ]

Schmidt R J — Support staff should not suffer, Pharmaceutical Journal 283(7582): 650-651 (2009) [ ISSN 0031-6873 ]

Schmidt R J — Remote supervision is here already, Pharmaceutical Journal 284(7588): 132 (2010) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/comment/remote-supervision-is-here-already/ 10994793.article ]

Schmidt R J — The emperor’s new clothes, Pharmaceutical Journal 284(7605): 578-579 (2010) [ ISSN 0031-6873 ]

Schmidt R J — Let us cut out the bureaucracy, Pharmaceutical Journal 285(7611/12): 114 (2010) [ ISSN 0031-6873 ]

Schmidt R J — Happiness is not a valid end-point, Pharmaceutical Journal 286(7653): 563 (2011) [ ISSN 0031-6873 ]

Schmidt R J — Paracetamol, ibuprofen and addiction, Pharmaceutical Journal 287(7671): 324 (2011) [ ISSN 0031-6873 ]

Schmidt R J — Gluten-free foods – Why should the taxpayer have to pay? Pharmaceutical Journal 288(7689): 68 (2012) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/gluten-free-foods-why- should-the-taxpayer-have-to-pay/11099485.article ]

Schmidt R J — Overuse of “take as directed”, Pharmaceutical Journal 289(7727): 396 (2012) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/overuse-of-take-as-directed/11108591.article ]

Schmidt R J — Confusion over chlorhexidine gluconate, Pharmaceutical Journal 290(7744): 151 (2013) [ ISSN 0031-6873 : https://doi.org/10.1211/PJ.2013.11116488 ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p 17! of 18! Schmidt R J — Time to address quality of training for pharmacy medicines counter assistants, Pharmaceutical Journal 291(7779): 374 (2013) [ ISSN 0031-6873 : https://doi.org/10.1211/PJ.2013.11128342 ]

Schmidt R J — When paracetamol might not be appropriate, Pharmaceutical Journal 292(7796): 139 (2014) [ ISSN 0031-6873 : https://doi.org/10.1211/PJ.2014.11133873 ]

Schmidt R J — Antimicrobial resistance, Pharmaceutical Journal 292(7814): 600 (2014) [ ISSN 0031-6873 : https:// doi.org/10.1211/PJ.2014.11138821 ]

Schmidt R J — A safe service does not mean it is a good service, Pharmaceutical Journal 293(7822/3): 151 (2014) [ ISSN 0031-6873 : http://www.pharmaceutical-journal.com/opinion/correspondence/a-safe-service-does-not-mean-it- is-a-good-service/20066040.article ]

Schmidt R J — We have to hurt to heal, Clinical Pharmacist 8(10): 300 (2016) [ ISSN 1758-9061 : https://doi.org/ 10.1211/CP.2016.20201621 ]

Schmidt R J — Pharmacists already possess technician skills, Pharmaceutical Journal 299(7903): 41 (2017) [ ISSN 0031-6873 : https://doi.org/10.1211/PJ.2017.20203058 ]

Schmidt R J — Study flawed by lack of comparative data, Clinical Pharmacist 9(7): 204 (2017) [ ISSN 1758-9061 : https://doi.org/10.1211/CP.2017.20202938 ]

Miscellaneous publications (book reviews)

Schmidt R J — Review of: Drug Targeting and Delivery. Concepts in dosage form design, Journal of Drug Development 5(4): 271-272 (1993) [ ISSN 0952-9500 ]

Schmidt R J — Review of: Excitatory Amino Acid Receptors. Design of agonists and antagonists, Journal of Drug Development 5(4): 272-273 (1993) [ ISSN 0952-9500 ]

Schmidt R J — Review of: The Pharmacology of Chinese Herbs, British Toxicology Society Newsletter (1): 10 (1994)

Schmidt R J — Review of: Peroxisomes: Biology and Importance in Toxicology and Medicine, British Toxicology Society Newsletter (3): 11 (1994)

Schmidt R J — Review of: The Carbonic Anhydrases, Journal of Pharmacy and Pharmacology 54(5): 735-736 (2002) [ ISSN 0022-3573 : https://doi.org/10.1211/0022357021778899 ]

Schmidt R J — Review of: Cells, Gels and the Engines of Life, Journal of Pharmacy and Pharmacology 55(6): 857-858 (2003) [ ISSN 0022-3573 : https://doi.org/10.1211/002235703765951483 ]

Miscellaneous publications (obituaries)

Schmidt R J — Obituary to Claude Benezra DSc, Contact Dermatitis 28(2): 57-58 (1993) [ ISSN 0105-1873 : https:// doi.org/10.1111/j.1600-0536.1993.tb03341.x ]

RJ Schmidt ~ Curriculum Vitae ~ February 2018 p 18! of 18!