International Journal of Research and Review Vol.7; Issue: 3; March 2020 Website: www.ijrrjournal.com Review Article E-ISSN: 2349-9788; P-ISSN: 2454-2237

Traditional Medicinal of Sariska Tiger Reserve Used in Diabetes

Praveen KR. Goyal, G. Jeyabalan

Alwar Pharmacy College, MIA, Alwar, Rajasthan, 301030, .

Corresponding Author: Praveen KR. Goyal

ABSTRACT became a wild life sanctuary in 1955 and Tiger reserve in 1982. According to Sariska Tiger Reserve, one of the 42 Tiger Department of Forest, Government of Reserves of India, is located near the civil Rajasthan the total area of the Sariska Tiger district of Alwar in Rajasthan. The Sariska Tiger Reserve is 866.0 km-2, of which 302.2 km-2 Reserve in Aravallis has its own importance and is buffer zone and 497.8 km-2 is core zone. specific characteristics with unique biodiversity. The forest of Sariska Tiger Reserve has great Sariska core zone is comprised of three diversity of flora. This paper gives an account of isolated; pockets: Core-I (273.8 km-2), II anti diabetic medicinal plants found in Sariska (126.5 km-2.) and III (97.5 km-2). The Tiger Reserve, along with their local name, status of the Core I has been notified as a family, habit and medicinal uses. Due to lack of National park in 1982. Sariska is undulating awareness, research unsustainable utilization to hilly and has numerous narrow valleys. and encroachments on these groups of in The forest being scattered and sparse over a this area, people of this region are unaware of large area on various geological and soil the wealth of this heritage and several persistent formation and vary greatly in composition. medicinal plant species are on the verge of Sariska is very rich in biodiversity with extinction .The present paper highlights useful wide spectrum of flora and ample of wild ethno botanical information about the uses of 4 these plants by the tribal of Rajasthan as food, life. fodder, medicine (fever, diarrhoea, diuretic, Anogeissus pendula (Dhok) is skin-problems, diabetes, hypertension, jaundice dominant species in the undulating area and etc.), timber, fire-wood, tannin, dye, oil, fibre, on the hills. Boswellia serrata (Salar) alcohol, gum, resin etc. Opuntia elatior (Prickly pear) and Lannea coromandelica (Garjan) grows on steep Keywords: Sariska, Diversity, Diabetes, rocky areas. Acacia catechu (Khair), Medicinal Plant Zizyphus mauritiana (Bordi), (Pulao) and Butea monosperma 1. INTRODUCTION (Dhak) are found in valleys.5 Rajasthan is quite rich in floristic A total number of 403 indigenous diversity probably due to presence of and naturalized plant species belonging to different variable and diversified climatic, 271 genera under 86 families can be physiographic, edaphic and habitat 1 observed in Sariska Tiger Reserve. This also conditions. The Sariska tiger reserve in includes four species of Pteridophytes Aravallis has its own importance and belonging to three genera and three families, specific characteristics endowed with 2 and a species of Gymnosperm. Table 1 unique biodiversity. Sariska National park includes the number of families, genera and is situated between the latitude (76*17’- species, under Dicotyledons and 76*34’Nand27*5’-27*33’E) and longitude 3 Monocotyledons, Pteridophytes and in the Alwar district of Rajasthan. It Gymnosperm. Except for Poaceae (56

International Journal of Research and Review (ijrrjournal.com) 130 Vol.7; Issue: 3; March 2020 Praveen KR. Goyal et.al. Traditional medicinal plants of Sariska tiger reserve used in diabetes species) and Cyperaceae (17 species) the (vii) extreme weakness and tiredness; (viii) Monocotyledons are poorly represented. irritability, mood changes etc.9 The remaining 16 species of Diabetes is rapidly growing Monocotyledons belong to 10 different worldwide, and affected 422 million people families.6 in 2014 and resulted in over 3 million A total of 110 species of plants representing deaths. The World Health Organization 88 genera and 43 families in Sariska used as (WHO) estimated that diabetes would be the traditional medicine in various disorder such seventh leading cause of death by the year as fever, diabetes, diorrhoea, , of 2030, and suggested that healthy lifestyle skin-problems, jaundice, rheumatism etc.7 and right medication and regular screening More over several difficult diseases can prevent and avoid the consequence of have problem related with vitality, diabetes, diabetes, respectively. memory loss, could be cured effectively by For many decades, medicinal plants use of , which is generally have been beneficial resources for the not possible by the Allopathic medicines.8 treatment of several diseases, including In the present study an attempt has diabetes. Some well-known drugs in been made to ascertain the current status of current-use for diabetes have been plant species which has medicinal and developed from plants such as metformin economical importance for the livelihood of drug derived from the Galega officinalis. local peoples inside and outside the Sariska Many studies have also indicated the forest. Present Paper highlights the floristic advantages of medicinal plants in the richness along with ethnobotanical wealth therapeutic development, for example of Sariska forest. This review focuses on availability and acceptable risk-benefit ratio. Indian Herbal drugs and plants from Sariska Though the ethno botanical community has forest used in the treatment of diabetes. reported a list of anti-diabetic medicinal 1.1 Diabetes and their management: plants, in the search for new treatments and Diabetes is a chronic disorder of cures, yet more medicinal plants are being carbohydrate, fat and protein metabolism explored for their therapeutic characterized by increased fasting and post development.10 prandial blood sugar levels. Diabetes Today, many treatments that involve mellitus is a complex metabolic disorder the use of medicinal plants are resulting from either insulin insufficiency or recommended. Most plants contain insulin dysfunction. Type I diabetes (insulin carotenoids, flavonoids, terpenoids, dependent) is caused due to insulin alkaloids, glycosides and can often have insufficiency because of lack of functional anti-diabetic effects. The anti- beta cells. Patients suffering from this are hyperglycemic effects that results from therefore totally dependent on exogenous treatment with plants are often due to their source of insulin while patients suffering ability to improve the performance of from Type II diabetes (insulin independent) pancreatic tissue, which is done by are unable to respond to insulin and can be increasing insulin secretions or reducing the treated with dietary changes, exercise and intestinal absorption of glucose.11 medication. Type II diabetes is the more Treatment includes diet, exercise, common form of diabetes constituting 90% and medication. Currently, the main and of the diabetic population. Symptoms for effective treatment for diabetes is the use of both diabetic conditions may include: (i) insulin and hypoglycemic drugs, but these high levels of sugar in the blood; (ii) compounds also have many adverse side unusual thirst; (iii) frequent urination; (iv) effects. Medicinal plants have a long history extreme hunger and loss of weight; (v) of usage and today, they are being blurred vision; (vi) nausea and vomiting; extensively used for various diseases. There are several reasons for increasing the use of

International Journal of Research and Review (ijrrjournal.com) 131 Vol.7; Issue: 3; March 2020 Praveen KR. Goyal et.al. Traditional medicinal plants of Sariska tiger reserve used in diabetes medicinal plants. Many plants from damage caused by streptozotocin to the different parts of the world have been pancreatic islets.14 investigated for antidiabetic effects.12 2.2 Acacia nilotica Pods and tender are considered very beneficial in folk medicine to treat diabetes mellitus. Acacia nilotica has been used traditionally for management of diabetes mellitus. The aqueous extracts of A. nilotica showed antidiabetic activity. The intraperitoneal route of herbal extract administration was found to be more effective than the oral route. Qualitative and quantitative phytochemical screening of aqueous leaf extracts of A. nialotica indicated the Fig:1 Map showing Sariska Tiger Reserve Rajasthan (Range, Village, Road)3 presence of phenols, alkaloids, flavonoids, tannins and saponins.15 Table 1 Shows current status of vegetation in Sariska Tiger Reserve.2 2.3 Anogeissus pendula Families Genera Species A study was carried out by to Monocotyledons 13 59 90 Dicotyledons 69 208 308 evaluate the antidiabetic potential of Total Angiosperm 82 267 398 Anogeissus acuminata on streptozotocin- Pteridophytes 3 3 4 Gymnosperm 1 1 1 induced diabetes mellitus. In this study DM Total 86 271 403 was induced in rats by injecting streptozocin. Rats were then treated with Table 2: Vegetation and land cover in Sariska National Park.13 Anogeissus acuminata extracts for 8 weeks S.No. Vegetation/ Landcover type Area Percentage (sq. km.) at doses of 100 and 300mg/kg. After that 1 Anogeissus dominated forest 283.3 35.43 plasma glucose levels and oxidative stress 2 Scrubland 152.5 19.07 3 Boswellia dominated forest 123.5 15.50 was assessed at weeks 1, 2, 4, and 8. The 4 Agriculture/Habitation 74.7 9.34 study results showed that Methanolic extract 5 Zizyphus mixed forest 63.6 7.95 6 Butea dominated forest 47.5 5.94 of AA leaves produced a hypoglycemic and 7 Acacia mixed forest 32.2 4.02 antioxidant effect. Urinary function was also 8 Barren land 20.6 2.58 improved. The study concluded that 9 Water body 1.6 0.20 Total 799.432 100 Anogeissus acuminata leaf extract demonstrated antidiabetic and antioxidant 2. Medicinal Plants of Sariska Forest action.16, 17 Used Traditionally as Antidiabetic: 2.4 Azadirachta indica 2.1 Aegle marmelos (Neem) is a medicinal plant, used in Aegle marmelos (Bael) fruit and Ayurveda for treating various diseases, one leaves exhibit antidiabetic, of which is diabetes mellitus. It is known to antihyperlipidaemic and antioxidant possess antiinflammatory, antipyretic, properties. Oral administration of Aegle antimicrobial, antidiabetic and diverse marmelos fruit extract at doses of 125 and pharmacological properties. Hypoglycaemic 250 mg/kg twice daily to diabetic rats for a effect was observed with Azadirachta indica period of 30 days resulted in a significant when given as a leaf extract and seed oil, in increase in body weight, weight of the normal as well as diabetic rabbits. The pancreas and insulin levels associated with a effect, however, was more pronounced in significant decrease in fasting blood glucose diabetic animals in which administration for levels. The fruit extract treated groups 4 weeks after alloxan induced diabetes, showed improved functional state of the significantly reduced blood glucose levels. pancreatic ss-cells and partially reversed the Hypoglycaemic effect was comparable to

International Journal of Research and Review (ijrrjournal.com) 132 Vol.7; Issue: 3; March 2020 Praveen KR. Goyal et.al. Traditional medicinal plants of Sariska tiger reserve used in diabetes that of glibenclamide. Pre-treatment with A. selected for screening in NIDDM model, by indica leaf extract or seed oil administration, OGTT (Oral- glucose tolerance test). For started 2 weeks prior to alloxan, partially this purpose, blood wastaken at 0 hrsfrom prevented the rise in blood glucose levels as the tail vein from overnight (12 hrs) fasted compared to control diabetic animals.18 rats and they were fed glucose at a dose of 2.5 Butea monosperma 2.5 gm /kg body weight. Then blood was Butea monosperma (Fabaceae), taken at 30, 60 and 120 minutes intervals. commonly known as palash, is widely used The rats having blood glucose level 7-12 in the treatment of various diseases and mmol/l at 0 hours and showing highest rise disorders including diabetes.19 The at 60 minutes with the blood sugar level 234 antihyperglycemic activity of the ethanolic to 360 mg/dl, which returned to their 0 hrs extract of Butea monosperma (BMEE) was value at 120 minutes, were included in the studied in glucose-loaded and alloxan- study. A significant increase in the levels induced diabetic rats. Single dose treatment ofserum glucose was evident in diabetic of BMEE (200 mg/kg, p.o.) significantly control group. The serum glucose levels improved glucose tolerance and caused reduced by 81.4%, 60.48% and 55.43% in reduction in blood glucose level in alloxan- fruit, flower and bark extract treatments induced diabetic rats. Repeated oral respectively.22 treatment with BMEE (200 mg/kg/day) for 2.8 Coccinia cordifolia 2 weeks significantly reduced blood Coccinia cordifolia glucose, serum cholesterol and improved (synonym Coccinia indica), an herb that HDL-cholesterol and albumin as compared belongs to the Cucurbitaceae family and that to diabetic control group.20 grows abundantly in sariska forest India, has 2.6 Carissa carandas L. been widely used in traditional treatment Carissa carandas (CC) has been of diabetes. are believed to heal used in folklore medicine for treatment of illnesses associated with endocrine system diabetes. Aqueous Extract of CC (AECC) disorders such as diabetes mellitus, and are was most active and showed fall of 67.08% used to treat intestinal troubles.23, 24 in fasting blood glucose from 0 to 1h in 2.9 Cayratia trifolia glucose tolerance test (GTT). The ED50 of Cayratia trifolia Linn. Syn. Vitis AECC was 300mg/kgbw in streptozotocin trifolia (Family: Vitaceae) is commonly induced diabetic rats. Treatment of diabetic known as Fox grape. Whole plant rats with ED50 of AECC for 28 days of Cayratia trifolia has been reported to significantly reduced post prandial glucose contain yellow waxy oil, (PPG) by 33.65% (p<0.01), glycosylated steroids/terpenoids, flavonoids, tannins hemoglobin (HbA1c) by 45.79% (p<0.01) upon preliminary phytochemical screening. and increased insulin level by 69.7% The bark extract shows the antiviral, (p<0.05). The results indicated that antibacterial, antiprotozoal, hypoglycemic, increaspe in insulin secretion may be partly anticancer and diuretic activity.25 Treatment responsible for antidiabetic effect of of streptozotocin induced diabetic rats with AECC.21 ethanolic extract (500 mg/kg) caused 2.7 Capparis deciduas significant (P < 0.01) reduction in blood Capparis decidua is xerophytic glucose (312–178 mg/dL), increase in body shrub, commonly known as Kair. Diabetes weight (181–219 g) and serum insulin (type 2) was induced in rats of either sex, (1.28–2.26 IU/dL). It also maintained lipid aged 48 ± 2 hrs, were injected with profile and tests of liver and kidney Streptozotocin in citrate buffer (pH 4.5) at a functions within normal range as compared dose of 90mg / kg body weight to diabetic control rats and almost at intraperitoneal route. After 12-14 weeks, par with standard drug metformin. The animalsweighing above 150 gm were oxidative stress induced decline in

International Journal of Research and Review (ijrrjournal.com) 133 Vol.7; Issue: 3; March 2020 Praveen KR. Goyal et.al. Traditional medicinal plants of Sariska tiger reserve used in diabetes glutathione and catalase in liver and kidney 2.12 Gymnema sylvestris tissues showed recovery nearly too normal Gymnema is a woody climbing level as a function of treatment. The GC– shrub native to India and Africa. The leaves MS profile of the extract showed relatively are used to treat Diabetes. Gymnema has a high concentration of β-sitosterol which was long history of use in India's Ayurvedic characterized by different spectroscopic and medicine. The Hindi name for gymnema chromatographic techniques.26 means destroyer of sugar.30 Extract from the 2.10 Dipteracanthus prostrates leaves of Gymnema sylvestre, in controlling Dipteracanthus prostratus (Poir) hyperglycaemia was investigated in 22 Type belongs to Acanthaceae family. Wistar 2 diabetic patients on conventional oral anti- albino rats were used to evaluate the hyperglycaemic agents. GS4 (400 mg/day) antihyperglycemic effect of toluene (TEDP, was administered for 18-20 months as a 100 mg/kg and 200 mg/kg, body weight) supplement to the conventional oral drugs. and methanolic (MEDP, 100 mg/kg and 200 During GS4 supplementation, the patients mg/kg, body weight) extract of D. showed a significant reduction in blood prostratus. Changes in body weight and glucose, glycosylated haemoglobin and blood glucose level were evaluated at the glycosylated plasma proteins, and beginning of the experiment and on day 7, conventional drug dosage could be 14, and 21 subsequently. Lipid profile and decreased. Five of the 22 diabetic patients histopathological examination were also were able to discontinue their conventional performed. TEDP at 200 mg/kg produced a drug and maintain their blood glucose significant stimulating body weight and homeostasis with GS4 alone.31 reduced blood glucose level in treated diabetic rats from day 7, apart that MEDP 2.13 Hibiscus rosasinensis also showed similar activity from day 14. Hibiscus rosa-sinensis, known Furthermore, significant differences in lipid as Chinese hibiscus, rose, is profiles by TEDP treated rats at 200 mg/kg, a species of tropical hibiscus, a flowering as compared to diabetic control and normal plant in the tribe of rats were also observed. Histopathological the family . The ethanol extract studies showed comparable regeneration of of flowers of Hibiscus rosasinensis at doses islet cells necrosed by Streptozotocin, by of 250 mg/kg and 500 mg/kg significantly both the extracts.27 reduced the blood glucose level in both 2.11 Euphorbia hirta acute (1, 3, 5 h) and sub acute (1, 3, 5, Euphorbia hirta (Family- 7 days) treatments.32 Euphorbiaceae) is widely used in traditional 2.14 Indigofera tinctoria (Fabaceae) system of medicine to treat diabetes in In Traditional system of medicine it India. It is reported to contain alkanes, has medicinal properties as it is used in triterpenes, phytosterols, tannins, constipation, liver disease, heart palpitation, polyphenols, and flavanoids.28 Oral gout, diabetes, bitter, thermogenic, laxative, administration of E. hirta leaves extract (300 trichogenous and expectorant.33 The mg/kg b.w./rat/day) for a period of 30 days methanolic extract of dried leaves of indicated the antidiabetic nature of the Indigofera tinctoria Linn showed significant leaves extract. Assay of enzymes such as decrease in blood glucose level of rabbits as serum aspartate transaminase (AST), serum estimated by Folin-Wu Method, alloxan is alanine transaminase (ALT) and serum used as diabetes inducing agent.34 alkaline phosphatase (ALP) revealed the 2.15 Kydia calycina: non-toxic nature of E. hirta leaves. The Kydia calycina is an evergreen tree hypoglycemic activity of the leaves extract growing 10 - 20 metres tall. Commonly was comparable with gliclazide, a standard known as Pula, Pattha, Pulia, belong to reference drug.29.

International Journal of Research and Review (ijrrjournal.com) 134 Vol.7; Issue: 3; March 2020 Praveen KR. Goyal et.al. Traditional medicinal plants of Sariska tiger reserve used in diabetes family Malvaceae. Traditionally used in ethanolic extracts were observed Boils, diabetes, febrifuge, rheumatism etc.35 antidiabetic effect for 12 consecutive days. 2.16 Opuntia Elatior BGL was monitored after1,3,6 and 12days Opuntia elatior Mill.(Cactaceae), a and compared withMetformin(250 folklore plant known as Nagaphani or mg/kg).Alpha amylase and alpha Hathlo-thore is widely available across the glucosidase activity of both extracts were globe and in India. O. elatior is being used also determined. Oral administration of both traditionally in different disease condition extracts showed significant (P < 0.05) like abscess & wound, burning sensation in antihyperglycemic activity in dose the stomach, diabetes, diphtheria, asthma dependent manner in alloxan induced and anemia. The principal constituents diabetic rats. The diabetic rats had present in the plant are â-sitosterol, opuntiol significant (P < 0.01) reduction in blood and opuntiol acetate. Plant shows notable glucose. The ethanolic and aqueous extract pharmacological activities such as reveals the reduction in the blood glucose haematinic, anti-inflammatory, analgesic, level, inhibition of alphaamylase and anti-leukemic and anti-ulcer activity alphaglucosidase enzymes which support including its safety reports during acute anti diabetic effect (reduce post prandial toxic study.36, 37 glucose levels) of Z. oenoplia and this may 2.17 oenoplia be due to presence of flavonoids At two different doses(200 constituents.38 mg/kgand400 mg/kgb.w.) of aqueous and

Table 3 Ethno medicinal Flora of the Sariska Forest used in Diabetes S.No Plant name Family & Habit Synonym Part used Traditional Uses 1 Aegle marmelos Rutaceae (T) Bael, Golden Fruit Fruit juice used traditionally in Diabetes, Anti apple oxidant39 2 Abutilon indicum Malvaceae (H) Kanghi Leaves, Roots Leaf and root extract used to treat Diabetes, Fever3 3 Acacia nilotica Mimosaceae (T) Babul Gum, Bark Powder of bark is applied externally in ulcers, Acacia arabica Extract used in diabetes 39 4 Anogeissus pendula Combretaceae Kardhai,Dhak Stem Bark Diabetes, Dysentery, Cough 40 (T) 5 Azadirachta indica Meliaceae (T) Neem Leaves,Bark and Leaves Extract used Antiseptic, Diabetes 39 fruit 6 Butea monosperma Fabaceae (T) Palash, Fire of Flower antibacterial, antifungal, hypoglycaemic 20 forest 7 Capparis decidua Capparaceae (S) Kair Fruit and Twig antidiabetic and antioxidant 22 8 Carissa carandas Apocynaceae conkerberry Stomachache, diabetic, anthelmintic 41 (S) 9 Cayratia trifolia Vitaceae Amlabel Bark antiprotozoal, hypoglycemic, anticancer 25 10 Coccinia cordifolia Cucurbitaceae Tindora, Tinda Leaf,Fruit, Antidiabetic, Hepatoprotective, asthma 23 (T) Root 11 Dipteracanthus Acanthaceae (T) Ruellia, Nees Ariel part antiulcer, antioxidant, Hypoglycemic 27 prostrates 12 Euphorbia hirta Euphorbiaceae Asthma weed Leaf, Flower, Asthma,Hypoglycemic 43 (H) Stem 13 Gymnema sylvestris Apocynaceae Gurmar Leaves Hypoglycemic, Hypolipidemic, obesity 44 (T) 14 Hibiscus Malvaceae (S) Rose mallow Leaves Extract used for Hair growth and rosasinensis hypoglycaemic 32 15 Hibiscus Malvaceae (S) Chanak Seed, Leaf Antifungal,Antiviral, Febrifuge,Hypoglycemic micranthus 32 16 Indigofera tinctoria Fabaceae (T) True Indigo Leaves Anti Diabetic, asthma, fever 33 17 Kydia calycina Malvaceae (T) Bharanga, Bhoti, Bark,Leaves Antidiabetic, skin diseases 35 Pula 18 Opuntia Elatior Cactaceae (T) Cactus, Fruit, Leaf antidiabetic, antihyperlipidemic, antioxidant HathlaThor 36 19 Sida acuta Malvaceae (H) Bala Leaf, Roots Astringent, cut,wounds, hypoglycemic 45 20 Sida cordifolia Malvaceae (H) country mallow Seed, leaves, Aphrodisiac, gonorrhea, anti diabetic 46 root 21 ziziphus oenoplia (T) Jackal jujube Bark Stomachic, hyperacidity , Hypoglycemic 38

International Journal of Research and Review (ijrrjournal.com) 135 Vol.7; Issue: 3; March 2020 Praveen KR. Goyal et.al. Traditional medicinal plants of Sariska tiger reserve used in diabetes

3. CONCLUSION Journal of Life Science & Pharma Research, In this review we discussed Sept 2013; 3 (2): 312-317 traditional medicinal plants from Sariska 9. Modak M, Dixit P, Londhe JS, Ghaskadbi Forest Dist. Alwar for the treatment of S. Indian Herbs and Herbal Drugs Used for Diabetes mellitus. Traditional medicinal the Treatment of Diabetes. Journal of Clinical Biochemistry and Nutrition 2017; plants are mostly used for rural areas. 40(3): 163-73 Therefore, treating hyperglycemia with 10. Selvaraj B, Periyasamy S. Indian medicinal plant derived product which are accessible plants for diabetes: Text data mining the and do not require laborious pharmaceutical literature of different electronic databases synthesis seems highly attractive. In the for future therapeutics. Biomedical present review an attempt has been made to Research 2016; Edition-I: 1-6 investigate the antidiabetic medicinal plants 11. Wesam K.The role of medicinal plants in from Sariska forest and may be useful to the the treatment of diabetes: a systematic health professionals, scientists and scholars review. Electronic physician Jan 2016; 8(1): working in the field of pharmacology, 1832-42 Pharmacognosy and therapeutics to develop 12. Moradi B, Abbaszadeh Somayeh Shahsavari Mohsen Alizadeh Fatemeh Beyranvand. hypoglycemic drugs. The most useful medicinal herbs to treat

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40. Marles RJ, Farnsworth NR. Antidiabetic 44. Parijat K. Gymnema sylvestre: A Memoir. plants and their active constituents. Journal of clinical biochemistry and Phytomedicine Oct 1995; 2(2): 137-89 nutrition 2007; 41(2): 77-81 41. Tesfaye T, Ravichadran Y. Traditional 45. Singh A, Navneet R. Pharmacological Uses, Pharmacological Action and Benefits of Natural Products. 1st Edition Phytochemical Analysis of Carissa carandas Mar- 2018: 144-155 Linn.: A Review. Natural Products 46. Jain A, Choubey S, Singour PK, Rajak H, Chemistry & Research 2018; 6 (5): 1-20 Pawar RS. Sida cordifolia (Linn) – An 42. Kumar D, Kumar S, Gupta J, Arya R, Gupta overview. Journal of Applied A. A review on chemical and biological Pharmaceutical Science 2011; 01 (02): 23- properties of Cayratia trifolia Linn. 31 (Vitaceae). Pharmacognosy Review. Jul 2011; 5(10): 184-8 How to cite this article: Goyal PKR, Jeyabalan 43. Kumar S, Malhotra R, Kumar D. Euphorbia G. Traditional medicinal plants of sariska tiger hirta: Its chemistry, traditional and reserve used in diabetes. International Journal of medicinal uses, and pharmacological Research and Review. 2020; 7(3): 130-138. activities. Pharmacognosy Review.Jun 2010; 4(7): 58-61

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International Journal of Research and Review (ijrrjournal.com) 138 Vol.7; Issue: 3; March 2020