Ziziphus Nummularia Attenuates the Malignant Phenotype of Human Pancreatic Cancer Cells: Role of ROS
molecules Article Ziziphus nummularia Attenuates the Malignant Phenotype of Human Pancreatic Cancer Cells: Role of ROS Joelle Mesmar 1,†, Manal M. Fardoun 1,†, Rola Abdallah 1,†, Yusra Al Dhaheri 2, Hadi M. Yassine 3 , Rabah Iratni 2 , Adnan Badran 4, Ali H. Eid 5,6,* and Elias Baydoun 1,* 1 Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon; jm104@aub.edu.lb (J.M.); mmf27@mail.aub.edu (M.M.F.); rha62@mail.aub.edu (R.A.) 2 Department of Biology, College of Science, United Arab Emirates University, Al-Ain P.O. Box 15551, United Arab Emirates; yusra.aldhaheri@uaeu.ac.ae (Y.A.D.); r_iratni@uaeu.ac.ae (R.I.) 3 Biomedical Research Center, Qatar University, Doha P.O. Box 2713, Qatar; hyassine@qu.edu.qa 4 Department of Basic Sciences, University of Petra, Amman P.O. Box 961343, Jordan; abadran@uop.edu.jo 5 Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar 6 Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha P.O. Box 2713, Qatar * Correspondence: ali.eid@qu.edu.qa (A.H.E.); eliasbay@aub.edu.lb (E.B.) † These authors contributed equally to this work. Abstract: Pancreatic cancer (PC) is the fourth leading cause of all cancer-related deaths. Despite major improvements in treating PC, low survival rate remains a major challenge, indicating the need Citation: Mesmar, J.; Fardoun, M.M.; for alternative approaches, including herbal medicine. Among medicinal plants is Ziziphus nummu- Abdallah, R.; Al Dhaheri, Y.; Yassine, laria (family Rhamnaceae), which is a thorny shrub rich in bioactive molecules.
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