Independent Research Resources Demonstrations/Simulations
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Intelligent Design, Abiogenesis, and Learning from History: Dennis R
Author Exchange Intelligent Design, Abiogenesis, and Learning from History: Dennis R. Venema A Reply to Meyer Dennis R. Venema Weizsäcker’s book The World View of Physics is still keeping me very busy. It has again brought home to me quite clearly how wrong it is to use God as a stop-gap for the incompleteness of our knowledge. If in fact the frontiers of knowledge are being pushed back (and that is bound to be the case), then God is being pushed back with them, and is therefore continually in retreat. We are to find God in what we know, not in what we don’t know; God wants us to realize his presence, not in unsolved problems but in those that are solved. Dietrich Bonhoeffer1 am thankful for this opportunity to nature, is the result of intelligence. More- reply to Stephen Meyer’s criticisms over, this assertion is proffered as the I 2 of my review of his book Signature logical basis for inferring design for the in the Cell (hereafter Signature). Meyer’s origin of biological information: if infor- critiques of my review fall into two gen- mation only ever arises from intelli- eral categories. First, he claims I mistook gence, then the mere presence of Signature for an argument against bio- information demonstrates design. A few logical evolution, rendering several of examples from Signature make the point my arguments superfluous. Secondly, easily: Meyer asserts that I have failed to refute … historical scientists can show that his thesis by not providing a “causally a presently acting cause must have adequate alternative explanation” for the been present in the past because the origin of life in that the few relevant cri- proposed candidate is the only known tiques I do provide are “deeply flawed.” cause of the effect in question. -
Molecular Biology for Computer Scientists
CHAPTER 1 Molecular Biology for Computer Scientists Lawrence Hunter “Computers are to biology what mathematics is to physics.” — Harold Morowitz One of the major challenges for computer scientists who wish to work in the domain of molecular biology is becoming conversant with the daunting intri- cacies of existing biological knowledge and its extensive technical vocabu- lary. Questions about the origin, function, and structure of living systems have been pursued by nearly all cultures throughout history, and the work of the last two generations has been particularly fruitful. The knowledge of liv- ing systems resulting from this research is far too detailed and complex for any one human to comprehend. An entire scientific career can be based in the study of a single biomolecule. Nevertheless, in the following pages, I attempt to provide enough background for a computer scientist to understand much of the biology discussed in this book. This chapter provides the briefest of overviews; I can only begin to convey the depth, variety, complexity and stunning beauty of the universe of living things. Much of what follows is not about molecular biology per se. In order to 2ARTIFICIAL INTELLIGENCE & MOLECULAR BIOLOGY explain what the molecules are doing, it is often necessary to use concepts involving, for example, cells, embryological development, or evolution. Bi- ology is frustratingly holistic. Events at one level can effect and be affected by events at very different levels of scale or time. Digesting a survey of the basic background material is a prerequisite for understanding the significance of the molecular biology that is described elsewhere in the book. -
Department of Pharmacology (GRAD) 1
Department of Pharmacology (GRAD) 1 faculty participate fully at all levels. The department has the highest DEPARTMENT OF level of NIH funding of all pharmacology departments and a great diversity of research areas is available to trainees. These areas PHARMACOLOGY (GRAD) include cell surface receptors, G proteins, protein kinases, and signal transduction mechanisms; neuropharmacology; nucleic acids, cancer, Contact Information and antimicrobial pharmacology; and experimental therapeutics. Cell and molecular approaches are particularly strong, but systems-level research Department of Pharmacology such as behavioral pharmacology and analysis of knock-in and knock-out Visit Program Website (http://www.med.unc.edu/pharm/) mice is also well-represented. Excellent physical facilities are available for all research areas. Henrik Dohlman, Chair Students completing the training program will have acquired basic The Department of Pharmacology offers a program of study that leads knowledge of pharmacology and related fields, in-depth knowledge in to the degree of doctor of philosophy in pharmacology. The curriculum is their dissertation research area, the ability to evaluate scientific literature, individualized in recognition of the diverse backgrounds and interests of mastery of a variety of laboratory procedures, skill in planning and students and the broad scope of the discipline of pharmacology. executing an important research project in pharmacology, and the ability The department offers a variety of research areas including to communicate results, analysis, and interpretation. These skills provide a sound basis for successful scientific careers in academia, government, 1. Receptors and signal transduction or industry. 2. Ion channels To apply to BBSP, students must use The Graduate School's online 3. -
Standard 2: CELL BIOLOGY – REVIEW of BASICS
Standard 2: CELL BIOLOGY – REVIEW OF BASICS CELL PART OR TYPE OF CELL WHERE FOUND WHAT DOES IT FUNCTION: MISCELLANEOUS ORGANELLE Prokaryotic cell Plant cell LOOK LIKE: Job it does in INFORMATION: things Eukaryotic cell Animal cell Describe or Draw the cell such as color, what it is Both Both made of, size, etc. plasma/cell See diagram Holds cell together Phospholipid bilayer with membrane both both Regulates what goes proteins in/out of cell Semipermeable cytoplasm both Clear thick jelly- Supports/protects both like material in cell cell organelles See diagram Control center nucleus eukaryotic both Contains DNA See diagram Where proteins are ribosome both both made See diagram Process proteins Golgi complex eukaryotic both that go to other /apparatus parts of cell Membrane-bound Digests materials lysosome eukaryotic animal sac of digestive within the cell enzymes Membrane-bound Stores water, food, One large one in plants vacuole eukaryotic both storage area waste and dissolved Many smaller ones in minerals animals endoplasmic Network of Transport materials Can be rough (with reticulum eukaryotic both membrane tubes throughout the cell ribosomes attached) or smooth (without ribosomes) See diagram Where cell respiration Called Powerhouse of cell mitochondria eukaryotic both occurs (releases Makes ATP from energy for cell to use) breaking down glucose See diagram Where photosynthesis Contains chlorophyll chloroplast eukaryotic plant takes place Converts light energy into chemical energy in glucose Some pro- and plant (also fungi Rigid structure -
Introduction to the Cell Cell History Cell Structures and Functions
Introduction to the cell cell history cell structures and functions CK-12 Foundation December 16, 2009 CK-12 Foundation is a non-profit organization with a mission to reduce the cost of textbook materials for the K-12 market both in the U.S. and worldwide. Using an open-content, web-based collaborative model termed the “FlexBook,” CK-12 intends to pioneer the generation and distribution of high quality educational content that will serve both as core text as well as provide an adaptive environment for learning. Copyright ©2009 CK-12 Foundation This work is licensed under the Creative Commons Attribution-Share Alike 3.0 United States License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/3.0/us/ or send a letter to Creative Commons, 171 Second Street, Suite 300, San Francisco, California, 94105, USA. Contents 1 Cell structure and function dec 16 5 1.1 Lesson 3.1: Introduction to Cells .................................. 5 3 www.ck12.org www.ck12.org 4 Chapter 1 Cell structure and function dec 16 1.1 Lesson 3.1: Introduction to Cells Lesson Objectives • Identify the scientists that first observed cells. • Outline the importance of microscopes in the discovery of cells. • Summarize what the cell theory proposes. • Identify the limitations on cell size. • Identify the four parts common to all cells. • Compare prokaryotic and eukaryotic cells. Introduction Knowing the make up of cells and how cells work is necessary to all of the biological sciences. Learning about the similarities and differences between cell types is particularly important to the fields of cell biology and molecular biology. -
Biochemistry Biotechnology Cell Biology
Undergraduate Biochemistry Opportunities www.ed.ac.uk/biology Biotechnology Cell Biology Biochem_Biotech_CellBio_A5.indd 1 21/05/2019 14:25 Biochemistry The programme combines coverage of the Biochemistry is the study of living systems at basic principles and knowledge underpinning the cellular and molecular level. This dynamic biotechnology and an appreciation of the field draws on a variety of subjects and has processes involved in converting an idea widespread application. Biochemistry applies a into a product. The objective is to provide a knowledge of chemistry and physical sciences firm foundation in molecular and microbial to investigate basic life processes. The subject biotechnology through compulsory sections has a major impact on modern medical research dealing with topics such as expression vectors, and upon the pharmaceutical, bioengineering, microbial fermentation, protein structure, drug agricultural and environmental industries. design and the development of antimicrobials and vaccines. The programme encourages the critical assessment of current developments in areas of Cell Biology biological interest. Modern cell biology is a dynamic discipline that combines the interests and techniques of many Biotechnology scientific fields. Cell biologists investigate the Biotechnology is concerned with industrial basic structural and functional units of life, the and biomedical applications of fundamental cells that compose all living organisms. They aim knowledge derived from biology. This covers to understand: cellular structure, composition many facets from making useful products and regulation, the organelles that cells contain, using microbial, plant or animal cells to using cell growth, nuclear and cellular division, and bioinformatics and structural biology to design cell death. Understanding how cells work is new drugs. Biotechnology is an exciting area fundamental to many areas of biology and is of with new developments each year in areas that particular importance to fields such as cancer affect us all. -
Molecular Biology and Applied Genetics
MOLECULAR BIOLOGY AND APPLIED GENETICS FOR Medical Laboratory Technology Students Upgraded Lecture Note Series Mohammed Awole Adem Jimma University MOLECULAR BIOLOGY AND APPLIED GENETICS For Medical Laboratory Technician Students Lecture Note Series Mohammed Awole Adem Upgraded - 2006 In collaboration with The Carter Center (EPHTI) and The Federal Democratic Republic of Ethiopia Ministry of Education and Ministry of Health Jimma University PREFACE The problem faced today in the learning and teaching of Applied Genetics and Molecular Biology for laboratory technologists in universities, colleges andhealth institutions primarily from the unavailability of textbooks that focus on the needs of Ethiopian students. This lecture note has been prepared with the primary aim of alleviating the problems encountered in the teaching of Medical Applied Genetics and Molecular Biology course and in minimizing discrepancies prevailing among the different teaching and training health institutions. It can also be used in teaching any introductory course on medical Applied Genetics and Molecular Biology and as a reference material. This lecture note is specifically designed for medical laboratory technologists, and includes only those areas of molecular cell biology and Applied Genetics relevant to degree-level understanding of modern laboratory technology. Since genetics is prerequisite course to molecular biology, the lecture note starts with Genetics i followed by Molecular Biology. It provides students with molecular background to enable them to understand and critically analyze recent advances in laboratory sciences. Finally, it contains a glossary, which summarizes important terminologies used in the text. Each chapter begins by specific learning objectives and at the end of each chapter review questions are also included. -
Biochemistry and Molecular Biology
School of Life Sciences / Department of Biochemistry and Biophysics BIOCHEMISTRY AND MOLECULAR BIOLOGY Revealing how life works Department of Biochemistry and Biophysics Oregon State University 2011 Agriculture and Life Sciences Building Corvallis, OR 97331 OSUBB 541-737-4511 biochem.oregonstate.edu College of Science Oregon State University 128 Kidder Hall Corvallis, OR 97331 541-737-4811 science.oregonstate.edu This publication will be made available in an accessible alternative format upon request. Please contact the College COLLEGE OF SCIENCE of Science at 541-737-4811 or [email protected]. ACADEMIC BROCHURE / 2020 Highlights • Solve problems at the What will you discover? intersection of biological and physical sciences with our The Department of Biochemistry and Biophysics offers nationally accredited program world-class faculty, a tradition of interdisciplinary in biochemistry, molecular and research, teaching excellence and extraordinary cellular biology, chemistry, laboratories to facilitate undergraduate learning. molecular genetics, physics and statistics. The department ranks high nationally and internationally in many research areas, including signal transduction, gene • Tailor your education to expression, epigenetics, metabolic regulation, structural specific career goals with three biology, and genetic code expansion technology. different options. The department offers two Bachelor of Science degrees, • Thrive in a smaller, supportive both accredited by the American Society for Biochemistry department within a world-class and Molecular Biology (ASBMB): research university. • Biochemistry and Molecular Biology (BMB) with • Pursue interdisciplinary research options in Advanced Molecular Biology, Computational projects with faculty across OSU. Molecular Biology, and Pre-medicine; • Participate in the Biochemistry • Biochemistry and Biophysics (BB) with options in Club for community, leadership Advanced Biophysics, Neuroscience, and Pre-medicine. -
1 a Primer on Molecular Biology
1APrimer on Molecular Biology Alexander Zien Modern molecular biology provides a rich source of challenging machine learning problems. This tutorial chapter aims to provide the necessary biological background knowledge required to communicate with biologists and to understand and properly formalize a number of most interesting problems in this application domain. The largest part of the chapter (its first section) is devoted to the cell as the basic unit of life. Four aspects of cells are reviewed in sequence: (1) the molecules that cells make use of (above all, proteins, RNA, and DNA); (2) the spatial organization of cells (“compartmentalization”); (3) the way cells produce proteins (“protein expression”); and (4) cellular communication and evolution (of cells and organisms). In the second section, an overview is provided of the most frequent measurement technologies, data types, and data sources. Finally, important open problems in the analysis of these data (bioinformatics challenges) are briefly outlined. 1.1 The Cell The basic unit of all (biological) life is the cell. A cell is basically a watery solution of certain molecules, surrounded by a lipid (fat) membrane. Typical sizes of cells range from 1 µm (bacteria) to 100 µm (plant cells). The most important properties Life of a living cell (and, in fact, of life itself) are the following: It consists of a set of molecules that is separated from the exterior (as a human being is separated from his or her surroundings). It has a metabolism, that is, it can take up nutrients and convert them into other molecules and usable energy. The cell uses nutrients to renew its constituents, to grow, and to drive its actions (just like a human does). -
Biology 302 Course Syllabus Cell and Molecular Biology Fall 2014
Biology 302 Course Syllabus Cell and Molecular Biology Fall 2014 Instructor: Dr. Karen K. Resendes Office Phone: 724-946-7211 Office: 222 Hoyt Science Center e-mail: [email protected] Course Description: The primary emphasis of this course will be the basic structure and function of the cell. We begin the semester by looking at the “smaller picture” – the basic types of organic molecules that contribute to cells. We then explore cellular processes by starting on the cell surface and working our way into the interior of the cell. General topics include membrane transport and signaling, gene expression, intracellular transport, structure and motility, energy conversions, and cell division. Laboratory exercises will reinforce many of concepts covered in lecture. This course assumes the student has learned and retained a basic understanding of the fundamental cellular concepts presented in Foundations I and II. Course Structure: Lecture: T, R 9:20AM – 11:00AM Laboratory: R 2:00PM – 5:00PM HSC 206 Hoyt 343 Office Hours: M and W 1PM-2:30 PM OR other times by appointment Simply email, call or ask me for a time that will work for you. The sole purpose of making an appointment is that I want to be sure that I will be in my office at the time you want to meet with me. Required: 1. Text: Alberts A., et al. Molecular Biology of the Cell. Fifth Edition. Garland Science Publishers. New York, NY. 2008 2.Composition-style, quad-lined laboratory notebook 3. Frequent visits to the Bio 302 coursepage on my.westminster for: -Laboratory Handouts - Primary research articles - Online quizzes -Detailed reading lists - Electronic Resources Course Objectives: This course is intended for those students majoring in biology, molecular biology, biochemistry, or neuroscience. -
Biochemistry and Molecular Biology (BMB) 1
Biochemistry and Molecular Biology (BMB) 1 BMB 372. Advanced Molecular Biology. (3 h) BIOCHEMISTRY AND Presents molecular mechanisms by which stored genetic information is expressed including the mechanisms for and regulation of gene MOLECULAR BIOLOGY (BMB) expression, protein synthesis, and genome editing. Emphasizes analysis and interpretation of experimental data from the primary literature. Also Interdisciplinary Major listed as BIO 372. P-BIO 213 and 214 and BIO 370/BMB 370/CHM 370 or BIO 265 and BIO 370/BMB 370/CHM 370. This interdisciplinary Bachelor of Science major, jointly offered by the Departments of Biology and Chemistry, provides a strong foundation BMB 372L. Advanced Molecular Biology Laboratory. (1.5 h) in biological chemistry and molecular biology, and related topics at Introduces modern methods of molecular biology to analyze and the interface of these two disciplines. The major is designed to build manipulate expression of genes and function of gene products. Also conceptual understanding and practical and critical thinking skills to listed as BIO 372L. P or C-BIO 372/CHM 372 or BMB 373/CHM 373. address current biological, biochemical, and biomedical challenges. A BMB 373. Biochemistry II. (3 h) required research experience spanning multiple semesters, culminating Examines the structure, function, and synthesis of proteins and nucleic in a senior project, will give students strong experimental skills and acids and includes advanced topics in biochemistry including catalytic provide insight into biochemical and molecular biological experimental mechanisms of enzymes and ribozymes, use of sequence and structure approaches and results that demonstrate the function of biological databases, and molecular basis of disease and drug action. -
Biochemistry Metabolism
Biochemistry Metabolism 07.11.2017 – 27.11.2017 Photosynthesis Gerhild van Echten-Deckert Tel. 73 2703 E-mail: [email protected] www.limes-institut-bonn.de Photosynthesis Light reaction: - Light absorption, generation of a high energy electron and oxidation of water - Electron transport from water to NADPH and generation of a proton-motive force -Synthesis of ATP Berg, Tymoczko, Stryer: Biochemistry “Dark reaction”: - CO2 conversion into carbohydrates consuming ATP and NADPH (Calvin Cycle) Photosynthesis is localized to the thylakoid membranes Lodish et al. Molecular Cell Biology Comparison of photosynthesis and oxidative phosphorylation Berg, Tymoczko, Stryer: Biochemistry Chlorophyll a is the main pigment capturing energy of light Lodish et al. Molecular Cell Biology Energy diagram indicating the electronic states of chlorophyll and their most important modes of interconversion Other light-absorbing pigments, such as carotenoids, extend the range of light that can be absorbed and used for photosynthesis The action spectrum of photosynthesis matches the absorption spectra of chlorophyll a and b and of -carotene The absorption of photons from two distinct photosystems (PSI and PSII + is required for complete electron flow from H2O to NADP Berg, Tymoczko, Stryer: Biochemistry Light absorption by reaction-centre chlorophylls causes a charge separation across the thylakoid membrane The energy of the absorbed light is used to strip an electron from a chlorophyll molecule of the reaction centre to a primary electron acceptor thereby acquiring a positive charge (generation of a strong oxidizing- and a strong reducing agent) Lodish et al. Molecular Cell Biology Subsequent electron flow and coupled proton movement Lodish et al.