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(19) United States (12) Patent Application Publication (10) Pub
US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist. -
1. CAMBODIA 1.1 General Situation 1.1.1 Drug Use There Are No
COUNCIL OF Brussels, 15 April 2014 THE EUROPEAN UNION (OR. en) 8990/14 CORDROGUE 26 ASIE 22 NOTE From: Japanese Regional Chair of the Dublin Group To: Dublin Group No. prev. doc.: 14715/13 Subject: Regional Report on South East Asia and China 1. CAMBODIA 1.1 General situation 1.1.1 Drug use There are no consistent statistics as to the exact number of people who use drugs in Cambodia. However the general consensus among the Royal Government of Cambodia and international agencies is that there are currently between 12,000 and 28,000 people who use drugs. Methamphetamine pills are the most widely used drug in Cambodia, although crystalline methamphetamine is becoming more widely available, with use on the rise, particularly in Phnom Penh and among unemployed youth. Whereas illicit drug use was previously concentrated primarily in urban settings, in recent years it has been expanding into rural areas, in particular in the provinces adjacent to Lao PDR and Thailand (INCSR Cambodia 2012). Drug use among women and within prisons appears to be on the rise (UNODC 2013). 8990/14 JV/fm 1 DG D 2C EN Table 1. Rank of primary drugs of concern in Cambodia, 2008-2012 Drug type 2008 2009 2010** 2011*** 2012**** Methamphetamine pills ● 2* 1 2 2 Crystalline methamphetamine ● 1* 2 1 1 Ecstasy ● ● ● 6 ● Cannabis ● ● 4 4 4 Heroin ● ● 3 5 ● Inhalants ● ● ● 3 3 Opium ● ● ● ● ● ● = Not reported Source(s): *NACD 2010a. **2010 rankings based on DAINAP data and Cambodia country reports. ***NACD 2012b. ****2012 rankings are based on data provided by the National Authority for Combating Drugs. -
Toxicology Times
TOXICOLOGY (800) 677-7995 TIMES www.sdrl.com A FREE Monthly Newsletter for Substance Abuse and Opioid Treatment Volume 5, Issue 7 Programs from San Diego Reference Laboratory July, 2015 Amphetamines (Part 1) Dr. Joseph E. Graas, Scientific Director most often used in inhalers and does not tite, increased stamina and physical energy, Dr. Edward Moore, Medical Director have the central nervous system activity nor increased sexual response/drive, involuntary any addictive properties. All of the com- body movements, increased perspiration, The term “amphetamines” has come to mean pounds that have the structure of hyperactivity, nausea and increased heart rate. a class of endogenous neurotransmitters that phenylethylamine will have this mixture of d This drug is highly addictive and tolerance stimulate the sympathetic nervous system. and l molecules. In the production of these develops quickly. Withdrawal is an extremely This is a broad class of various substituted drugs they are usually noted as a racemic unpleasant experience. A few street names derivatives of phenylethylamine. This grow- mixture, or specifically, as the d or l com- for the drug are amp, speed, crank, dolls and ing class of structurally related molecules may pound. To properly evaluate this family of crystal. also stimulate the sympathetic nervous sys- compounds known as sympathomimetic tem in many different ways, such as affecting amines, amphetamines or phenylethylamine, Methamphetamine was developed by the the re-release of neurotransmitters or pre- it is best done by describing each member of Japanese in 1919 and used during World War venting the re-uptake of neurotransmitters, the class: amphetamine , methampheta- II to help soldiers stay alert and energize hallucinogens, anorectics, bronchodilators mine , phentermine , phenylpropanola- factory workers. -
MRO Manual Before 2004
Note: This manual is essentially the same as the 1997 HHS Medical Review Officer (MRO) Manual except for changes related to the new Federal Custody and Control Form (CCF). The appendix has also been deleted since the new Federal Custody and Control Form is available as a separate file on the website. Medical Review Officer Manual for Federal Agency Workplace Drug Testing Programs for use with the new Federal Drug Testing Custody and Control Form (OMB Number 0930-0158, Exp Date: June 30, 2003) This manual applies to federal agency drug testing programs that come under Executive Order 12564 and the Department of Health and Human Services (HHS) Mandatory Guidelines. Table of Contents Chapter 1. The Medical Review Officer (MRO) ............................................................... 1 Chapter 2. Federal Drug Testing Custody and Control Form .......................................... 3 Chapter 3. The MRO Review Process ............................................................................ 3 A. Administrative Review of the CCF ........................................................................... 3 I. State Initiatives and Laws ....................................................................................... 15 Chapter 4. Specific Drug Class Issues .......................................................................... 15 A. Amphetamines ....................................................................................................... 15 B. Cocaine ................................................................................................................ -
Monoamine Reuptake Inhibitors in Parkinson's Disease
Hindawi Publishing Corporation Parkinson’s Disease Volume 2015, Article ID 609428, 71 pages http://dx.doi.org/10.1155/2015/609428 Review Article Monoamine Reuptake Inhibitors in Parkinson’s Disease Philippe Huot,1,2,3 Susan H. Fox,1,2 and Jonathan M. Brotchie1 1 Toronto Western Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 2Division of Neurology, Movement Disorder Clinic, Toronto Western Hospital, University Health Network, University of Toronto, 399BathurstStreet,Toronto,ON,CanadaM5T2S8 3Department of Pharmacology and Division of Neurology, Faculty of Medicine, UniversitedeMontr´ eal´ and Centre Hospitalier de l’UniversitedeMontr´ eal,´ Montreal,´ QC, Canada Correspondence should be addressed to Jonathan M. Brotchie; [email protected] Received 19 September 2014; Accepted 26 December 2014 Academic Editor: Maral M. Mouradian Copyright © 2015 Philippe Huot et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The motor manifestations of Parkinson’s disease (PD) are secondary to a dopamine deficiency in the striatum. However, the degenerative process in PD is not limited to the dopaminergic system and also affects serotonergic and noradrenergic neurons. Because they can increase monoamine levels throughout the brain, monoamine reuptake inhibitors (MAUIs) represent potential therapeutic agents in PD. However, they are seldom used in clinical practice other than as antidepressants and wake-promoting agents. This review article summarises all of the available literature on use of 50 MAUIs in PD. The compounds are divided according to their relative potency for each of the monoamine transporters. -
Methamphetamine and Other Potentially Risky Sex-Enhancing Drugs
METHAMPHETAMINE AND OTHER POTENTIALLY RISKY SEX-ENHANCING DRUGS A DISSERTATION SUBMITTED TO THE FACULTY OF THE AMERICAN ACADEMY OF CLINICAL SEXOLOGISTS AT MAIMONIDES UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY BY DAVID MICHAEL FAWCETT ALFREDO EUGENIO TAULE' NORTH MIAMI BEACH, FLORIDA DECEMBER, 2004 DISSERTATION APPROVAL This dissertation submitted by David Michael Fawcett and Alfredo Eugenio Taule' has been read and approved by three faculty members of the American Academy of Clinical Sexologists at Maimonides University. The final copies have been examined by the Dissertation Committee and the signatures which appear here verify the fact that any necessary changes have been incorporated and the dissertation is now given the final approval with reference to content, form and mechanical accuracy. The dissertation is therefore accepted in partial fulfillment of the requirements for the degree of Doctor of Philosophy. Signature Date ______________________________ ______________ William Granzig, Ph.D., FAACS Advisor and Committee Chair ______________________________ _______________ John Achinapura, Ph.D. Committee Member ______________________________ _______________ James Walker, Ph.D. Committee Member ii ACKNOWLEDGEMENTS I dedicate this dissertation to my first born son Timothy who at the age of thirty-four after the terrorist attack in New York and Washington became a part of our proud military forces. At present he is a proud Airborne Ranger protecting our nation in a dangerous forward zone in the Sunni Triangle in Iraq. Timothy's resolve and courage as well as all of his accomplishments in such a short period of time have become a great source of inspiration for our family. My son has become my hero and he has made me aware of noble feelings like honor, loyalty, patriotism and commitment. -
Amphetamine Use Among Workers with Severe Hyperthermia
Morbidity and Mortality Weekly Report Notes from the Field Amphetamine Use Among Workers with Severe National Weather Service observation stations, the maximum Hyperthermia — Eight States, 2010–2019 outdoor heat index (a metric that combines temperature and Andrew S. Karasick, MD1,2; Richard J. Thomas, MD1; relative humidity into a single number that represents how hot Dawn L. Cannon, MD1; Kathleen M. Fagan, MD1; Patricia A. Bray, MD1; the conditions feel to humans) ranged from 86°F to 107°F 1 1 Michael J. Hodgson, MD ; Aaron W. Tustin, MD (median = 97°F) on the days of the nine incidents. Seven of the nine workers died, and two survived life-threat- Workers can develop hyperthermia when core body tem- ening illnesses. Peak body temperature ranged from 103°F to perature rises because of heat stress (environmental heat plus 110.6°F (39.4°C to 43.7°C) in eight workers with confirmed metabolic heat from physical activity) (1). Amphetamines are severe hyperthermia. In one fatality with no premortem body central nervous system stimulants that can induce hyperthermia temperature measurement, the medical examiner suspected independently or in combination with other risk factors (2). that hyperthermia was a significant contributing condition, During 2010–2016, the Directorate of Technical Support and based upon the circumstances (i.e., death occurred in a hot Emergency Management’s Office of Occupational Medicine environment after strenuous activity on a hot day) and lack and Nursing (OOMN), at the Occupational Safety and Health of anatomic evidence of an alternative cause of death (e.g., Administration (OSHA), identified three workers with fatal myocardial infarction). -
Methamphetamine Use: Lessons Learned
The author(s) shown below used Federal funds provided by the U.S. Department of Justice and prepared the following final report: Document Title: Methamphetamine Use: Lessons Learned Author(s): Dana Hunt, Ph.D.; Sarah Kuck; Linda Truitt, Ph.D. Document No.: 209730 Date Received: February 2006 Award Number: 99-C-008 This report has not been published by the U.S. Department of Justice. To provide better customer service, NCJRS has made this Federally- funded grant final report available electronically in addition to traditional paper copies. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice. ANALYTIC SUPPORT PROGRAM CONTRACT TASK REQUIREMENT T-043: Methamphetamine Use: Lessons Learned Contract No. 99-C-008 Cambridge, MA Lexington, MA Hadley, MA Bethesda, MD Chicago, IL January 31, 2006 Prepared for Raymond C. German Contracting Officer Christine Crossland Senior Social Science Analyst National Institute of Justice Office of Justice Programs Acquisition Management Division 810 Seventh Street, SW Washington, D.C. 20001 Prepared by Dana Hunt, Ph.D. Sarah Kuck Abt Associates Inc. Linda Truitt, Ph.D. 55 Wheeler Street Cambridge, MA 02138 Contents Executive Summary...............................................................................................................iii History of Methamphetamine Use .................................................................................iii Trends.............................................................................................................................iii -
National Drug Threat Assessment 2002
National Drug Intelligence Center U.S. Department of Justice U.S. Department of Justice National Drug Intelligence Center Product No. 2002-Q0317-001 December 2001 National Drug Threat Assessment 2002 National Drug Intelligence Center 319 Washington Street, 5th Floor Johnstown, PA 15901-1622 (814) 532-4601 National Drug Threat Assessment 2002 From the Director: I am pleased to present the National Drug Threat Assessment 2002, the culmination of dedicated work by the National Drug Intelligence Center in partnership with federal, state, and local agencies and organizations. In accordance with the provisions of the General Counterdrug Intelligence Plan, the National Drug Threat Assessment integrates foreign and domestic counterdrug intelligence and information on domestic drug consumption trends in a single report. This report is a comprehensive assessment of the threat posed to our society by illicit drugs. It integrates the most recently available reporting from national-level law enforcement, intelligence, and health and human service agencies including the Drug Enforcement Administration, Federal Bureau of Investigation, U.S. Coast Guard, U.S. Customs Service, El Paso Intelligence Center, Financial Crimes Enforcement Network, Crime and Narcotics Center, National Institute on Drug Abuse, Substance Abuse and Mental Health Services Administration, and National Institute of Justice. It incorporates data from current national drug abuse indicators—Arrestee Drug Abuse Monitoring Program, Drug Abuse Warning Network, Monitoring the Future Study, National Household Survey on Drug Abuse, Parents’ Resource Institute on Drug Education Survey, and Treatment Episode Data Set—to accurately and reliably depict the current domestic drug abuse situation. The National Drug Threat Assessment draws on information provided by nearly 2,600 state and local law enforcement agencies throughout the country to document the current threat and emerging trends in drug trafficking and related criminal activity in the United States. -
Chiral Separation of Methamphetamine and Amphetamine on an Agilent Infinitylab Poroshell 120 Chiral-V Column with Detection by LC/MS
Application Note Clinical Research Chiral separation of methamphetamine and amphetamine on an Agilent InfinityLab Poroshell 120 Chiral-V column with detection by LC/MS Authors Abstract Carl Griffin and William Long An Agilent InfinityLab Poroshell 120 Chiral-V 2.1 × 150 mm, 2.7 μm column Agilent Technologies, Inc. (p/n 683775-604) was used to analyze methamphetamine and amphetamine Wilmington, DE, USA by LC/MS, using a mobile phase of methanol with 0.1 % acetic acid and 0.02 % ammonium hydroxide. The analysis was accomplished in 5 minutes, with a resolution Rs of 1.9 or better for racemic amphetamine and methamphetamine. Introduction H NH Experimental N 2 Superficially porous particle columns are An Agilent 1290 Infinity LC system CH3 a popular tool in liquid chromatography. with an Agilent 6460 triple quadrupole Superficially porous particle columns (S)-(+)-Methamphetamine (S)-(+)-Amphetamine LC/MS was used in this experiment. The generate high efficiency at lower Dextromethamphetamine Dextroamphetamine system was modified from its standard pressure relative to their totally porous configuration to have low system volume 1 particle column counterparts . This is H NH and dispersion. Table 1 shows the primarily due to a shorter mass transfer N 2 instrument configuration details. Table 1 distance and substantially narrower CH lists the Agilent InfinityLab Poroshell 120 particle size distribution of the particles 3 Chiral-V 2.1 × 150 mm, 2.7 μm column in the column2. The current trend with (R)-(–)-Methamphetamine (R)-(–)-Amphetamine used in this work. Table 2 shows the LC superficially porous particles is reducing Levomethamphetamine Levoamphetamine and MS parameters. -
Concepts and Opinions About the Use of Stimulant Medications
Journal of Child Psychology and Psychiatry 50:1-2 (2009), pp 180–193 doi:10.1111/j.1469-7610.2008.02062.x Psychopharmacology: concepts and opinions about the use of stimulant medications James M. Swanson and Nora D. Volkow This ‘perspective piece’ on the topic of psychophar- Many reviews have been published to summarize macology was requested to be opinion-driven and the plethora of studies that followed, including conceptual in nature, rather than a systematic influential early reviews in this journal (see Barkley, review or a state-of-the-science article. Recently we 1977) and from the European perspective by Taylor (Volkow & Swanson, 2008a) adopted a broad (1979) and in this journal by Bramble (2003). All approach to address multiple classes of psychotropic seem to reach about the same basic conclusions medication used to treat children (stimulants, anti- about the effects of AMP and MPH that were reported depressants, and anti-psychotics). We provided in these initial studies. Fifteen years ago these were examples from traditional clinical pharmacology to summarized by Swanson et al. (1993) in a ‘review of discuss their pharamacokinetic (PK) and pharma- reviews’ that suggested what should be expected codynamic (PD) properties, as well as examples from (e.g., short-term reduction in symptoms of ADHD modern positron emission tomography (PET) brain and associated features of opposition and aggres- imaging to characterize the time course of drug sion) and what should not be expected (long-term effects at the primary cellular sites of action in the benefits, absence of side effects, paradoxical re- brain (transporters, enzymes, and receptors). -
WAC 246 -887 CHAPTER.Fm
Chapter 246-887 Chapter 246-887 WAC PHARMACY—REGULATIONS IMPLEMENTING THE UNIFORM CONTROLLED SUBSTANCES ACT WAC 18.64.005 and chapter 18.64A RCW. WSR 91-18-057 246-887-020 Uniform Controlled Substances Act. (Order 191B), recodified as § 246-887-070, filed 246-887-040 Designation of nonnarcotic stimulant drugs for purposes 8/30/91, effective 9/30/91. Statutory Authority: RCW of RCW 69.50.402 (1)(c). 69.50.201. WSR 89-17-023 (Order 226), § 360-36-260, 246-887-045 Prescribing, dispensing, or administering of Schedule II filed 8/8/89, effective 9/8/89; Order 138, § 360-36-260, nonnarcotic stimulants. filed 11/8/77.] Repealed by WSR 12-21-118, filed 246-887-080 Sodium pentobarbital registration disciplinary action. 10/23/12, effective 11/23/12. Statutory Authority: RCW 246-887-090 Authority to control. 69.41.080, 69.50.310, and 18.64.005. Later promulga- 246-887-100 Schedule I. tion, see chapter 246-886 WAC. 246-887-110 Adding MPPP to Schedule I. 246-887-220 Chemical capture programs. [Statutory Authority: RCW 246-887-120 Adding PEPAP to Schedule I. 69.50.320, 18.64.005. WSR 05-20-106, § 246-887-220, 246-887-130 Adding MDMA to Schedule I. filed 10/5/05, effective 11/8/05.] Repealed by WSR 15- 246-887-131 Adding Methcathinone to Schedule I. 12-020, filed 5/22/15, effective 6/22/15. Statutory 246-887-132 Adding Aminorex to Schedule I. Authority: RCW 18.64.005, 69.50.320, 69.41.080, and 246-887-133 Adding Alpha-ethyltryptamine to Schedule I.