DOCSLIB.ORG

Anne Mclaren

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Anne Mclaren RESEARCH HIGHLIGHTS AN INTERVIEW WITH… Anne McLaren day would turn into mice if one transferred Last month, the 2007 March of Dimes Prize them into the uterus. And I guess this in Developmental Biology was awarded to Dr Janet Rossant from The Hospital for Sick was partly because, this was in the Royal Children in Toronto, Canada, and Dame Veterinary College in London now, he had Anne McLaren from The Gurdon Institute in a culture system set up in his lab; he was Cambridge, UK. In the May issue of Nature working on cultured chick bones and I Reviews Genetics, we published an excerpt was working on embryo transfer. So we got from a conversation with Dr Janet Rossant. chatting and thought it would be interesting This month we talked to Dr Anne McLaren. Magdalena Skipper asked her about her reasons for to culture the embryos… choosing a career in biology and what prompted her to make some key transitions in her research. Below, Dr McLaren shares her reflections on her life in research so far and her views on some You are a President of the Association of current issues including ethics and women in science. Women in Science and Engineering and are well known for your support of women Wikipedia describes your family as “industrial fascinating or memorable problem you had to in science. The fact that men outnumber magnates known for their attention to liberal grapple with? women in most walks of science has attracted politics and women’s suffrage”. Were you That’s an impossible question to answer. But different explanations and comments… encouraged to study science? my early career very much followed the focus Except in biology! Certainly at the moment No I wasn’t. Not at all, it was rather of March of Dimes — I started my Ph.D. there are more women students in biology disapproved of. It was not a suitable thing on neurotropic viruses in mice; it was the labs than there are in other sciences. for young women. days when polio was pandemic, like HIV is today, that was before the vaccines. […] One And in the other disciplines that are more Why did you decide to study it despite the was very much encouraged to do animal male dominated, how does one encourage discouragement? model studies. After that I was concerned female scientists? I wanted to go to college and I was put down with reproductive biology: fetal growth, It is a difficult issue. But I think that a lot of for entrance in English literature because prematurity, birth weight and also congenital the postdoctoral fellowships that are given I was quite good at writing essays. But when I malformations. My first 20 years in research now are much more family-friendly … read the requirements for the exams I realized was very much involved with all of that. And there is good maternity leave, there is extra that it meant reading a lot of literature that then I moved on more towards the culture of support for childcare while at conferences I’d never ever read and I only had 8 months embryos and making chimaeras, and later on … that makes a lot of difference. But in the to swat for the scholarship exam, so that was still I got interested in germ cells, which I UK, certainly, there is insufficient affordable, no good, and so I looked at all the papers am still interested in. And stem cells… convenient, available childcare. It’s different and biology was easiest — you didn’t have to from one country to another… read so much, you could swat it all up from What guided those transitions? There is also a certain amount of ‘old textbooks, as opposed to reading novels and The choice of neurotropic viruses was boy’s network’, you know, men tend to think poems … you know, Milton’s Paradise Lost, pragmatic — I needed to get a Ph.D. in of their men-friends when jobs are going. every play by Shakespeare… 2 years because my first year hadn’t worked But there is a growing ‘old women’s When I got to Oxford I had to do a year out. And viruses breed much quicker than network’ now. or two of science in general so I did zoology, rabbits. At that time, infantile paralysis, as physics and maths. But I found zoology at polio was called then, was known to affect You had a role in establishing the UK’s the end of it most interesting so that’s what I young, athletically minded people, and people Human Fertilisation and Embryo Authority carried on with. noticed that it tended to be the limbs that (HFEA). What do you think about some they were using that were affected. I found in recent criticisms of HFEA and suggestions How do you remember those early days in the mice that if the neutrotropic virus was merely that it might be outdated? laboratory? circulating in the blood there was no paralysis, HFEA is doing very well and is well thought It was fascinating because it was very but if one lowered the blood–brain barrier by of. It has coped quite sensibly with recent polarized. This was the early 1950s, the injecting a drug into one of the limbs then that problems with cytoplasmic hybrids where Cold War … and the department was very limb would become paralysed because the cow and rabbit eggs have been used to make much split between left wing and right wing virus was able to get into the nervous system. stem-cell lines for research. politically. […] Everybody was friendly but And that made the newspapers. HFEA is being merged now with the there were lively discussions, shall we say… Human Tissue Authority, and it will be And the switch to cell culture? interesting to see how that works out; it’ll You have mainly studied fertility and germline Well, with my colleague John Biggers, we were be a much bigger organization but the two development. What was the hardest, most the first to show that embryos cultured for a have a lot in common. 412 | JUNE 2007 | VOLUME 8 www.nature.com/reviews/genetics © 2007 Nature Publishing Group .
Load more

Recommended publications
  • AIRE Is a Critical Spindle-Associated Protein in Embryonic Stem Cells Bin Gu1, Jean-Philippe Lambert2, Katie Cockburn1, Anne-Claude Gingras2,3, Janet Rossant1,3*
    RESEARCH ARTICLE AIRE is a critical spindle-associated protein in embryonic stem cells Bin Gu1, Jean-Philippe Lambert2, Katie Cockburn1, Anne-Claude Gingras2,3, Janet Rossant1,3* 1Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada; 2Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, Canada; 3Department of Molecular Genetics, University of Toronto, Toronto, Canada Abstract Embryonic stem (ES) cells go though embryo-like cell cycles regulated by specialized molecular mechanisms. However, it is not known whether there are ES cell-specific mechanisms regulating mitotic fidelity. Here we showed that Autoimmune Regulator (Aire), a transcription coordinator involved in immune tolerance processes, is a critical spindle-associated protein in mouse ES(mES) cells. BioID analysis showed that AIRE associates with spindle-associated proteins in mES cells. Loss of function analysis revealed that Aire was important for centrosome number regulation and spindle pole integrity specifically in mES cells. We also identified the c-terminal LESLL motif as a critical motif for AIRE’s mitotic function. Combined maternal and zygotic knockout further revealed Aire’s critical functions for spindle assembly in preimplantation embryos. These results uncovered a previously unappreciated function for Aire and provide new insights into the biology of stem cell proliferation and potential new angles to understand fertility defects in humans carrying Aire mutations. DOI: 10.7554/eLife.28131.001 *For correspondence: janet. [email protected] Introduction Competing interests: The Self-renewal capability, defined as the ability of cells to proliferate while sustaining differentiation authors declare that no potential, is one of the defining features of stem cells (Martello and Smith, 2014).
    [Show full text]
  • Beacon in Developmental Biology
    NEWS Beacon in developmental biology n Cite as: CMAJ 2017 October 16;189:E1298-9. doi: 10.1503/cmaj.109-5460 Posted on cmajnews.com on September 27, 2017. he identification of Gurdon, whom some people the genes responsi- may know recently received ble for controlling the Nobel Prize for his work Tcellular fate and embryonic cloning frogs; undertaking development in mice has research that demonstrates made Dr. Janet Rossant a that all of development is beacon in the field of written in our genes, and all developmental biology. of our cells contain DNA that Her work pioneered tech- has that information, yet niques that allowed genes somehow during develop- to be altered within ment, different genes are embryos. It also acceler- turned on and differentiation ated avenues in the fields occurs. That’s what really of stem cell biology and turned me on to the underly- regenerative medicine. ing problem of ‘how do we She was awarded the get from a fertilized egg to an 2015 Canada Gairdner organism?’ John is the per- Wightman Award, pre- son who really turned me on sented annually to a Cana- to that question and he has dian who has demon- been pursuing it ever since strated outstanding and so have I.” leadership in medicine and medical science. Rossant For the diverse audience was recognized “for her who read CMAJ, can you outstanding contributions explain what stem cells to developmental biology are? and for her exceptional “Stem cells are cells that international leadership in have the ability to self- stem cell biology and pol- renew, make endless copies icy-making, and in advanc- of themselves and yet also ing research programs for retain the potential to differ- children’s illnesses.” Courtesy of Dr.
    [Show full text]
  • Anne Laura Dorinthea Mclaren (1927-2007) [1]
    Published on The Embryo Project Encyclopedia (https://embryo.asu.edu) Anne Laura Dorinthea McLaren (1927-2007) [1] By: Khokhar, Aroob Keywords: Biography [2] Mice [3] Fertilization [4] Anne Laura Dorinthea McLaren was a developmental biologist known for her work withe mbryology [5] in the twentieth century. McLaren was the first researcher to grow mouse [6] embryos outside of the womb [7]. She experimented by culturing mouse [6] eggs and successfully developing them into embryos, leading to advancements with in vitro [8] fertilization [9]. McLaren was born in London, England, on 26 April 1927 to Christabel McNaughten and Henry Duncan McLaren, 2nd Baron Aberconway, who was a politician and industrialist. Growing up, McLaren wanted to pursue an education in English literature, but instead entered Lady Margaret Hall, Oxford, with a scholarship to study zoology. During her undergraduate work, McLaren became intrigued with genetics, in part due to her tutor, Edmund Brisco Ford [10]. After graduating with a honors degree in zoology, she continued her research with geneticist John Burdon Sanderson Haldane at University College London [11] on mite infestation in Drosophila [12]. McLaren continued to pursue her education and in 1952 graduated with a PhD from Oxford University where she studied mice neurotropic viruses with professor Kingsley Sanders [13], furthering her career in genetics. That same year, McLaren wed Donald Michie [14], who also studied and obtained his PhD at Oxford University. They continued working on the genetics of mice with Peter Medawar [15] at University College London [11] and the Royal Veterinary College (RVC) together. At RVC, McLaren worked with researcher John Biggers [16] on the cultivation of mouse [6] embryos, leading to a major technical advance in the history of embryology [5].
    [Show full text]
  • Annual Report Fy 2018 Human Frontier Science Program Organization
    APRIL 2017 APRIL 2018 — MARCH 2019 ANNUAL REPORT FY 2018 HUMAN FRONTIER SCIENCE PROGRAM ORGANIZATION The Human Frontier Science Program Organization (HFSPO) is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontier of the life sciences. Special emphasis is given to the support and training of independent young investigators, beginning at the postdoctoral level. The Program is implemented by an international organisation, supported financially by Australia, Canada, France, Germany, India, Italy, Japan, the Republic of Korea, New Zealand, Norway, Singapore, Switzerland, the United Kingdom of Great Britain and Nothern Ireland, the United States of America, and the European Commission. Since 1990, over 7000 researchers from more than 70 countries have been supported. Of these, 28 HFSP awardees have gone on to receive the Nobel Prize. 2 The following documents are available on the HFSP website www.hfsp.org: Joint Communiqués (Tokyo 1992, Washington 1997, Berlin 2002, Bern 2004, Ottawa 2007, Canberra 2010, Brussels 2013, London 2016): https://www.hfsp.org/about/governance/membership Statutes of the International Human Frontier Science Program Organization: https://www.hfsp.org/about/governance/hfspo-statutes Guidelines for the participation of new members in HFSPO: https://www.hfsp.org/about/governance/membership General reviews of the HFSP (1996, 2001, 2006-2007, 2010, 2018): https://www.hfsp.org/about/strategy/reviews Updated and previous lists of awards, including titles and abstracts:
    [Show full text]
  • Balancing Potency and Differentiation in Mouse Embryo-Derived Stem Cells and in Vivo
    Balancing potency and differentiation in mouse embryo-derived stem cells and in vivo By Anne Christine Helness A thesis submitted to Imperial College London for the degree of Doctor of Philosophy Department of Surgery and Oncology Imperial College London September 2011 1 Abstract An inherent challenge for developing organisms is to maintain a critical balance between cell potency and differentiation. This is most obvious in embryonic stem (ES) cells where genetic, epigenetic and cell signalling pathways support ES cell ability to self-renew and to generate all embryonic lineages. Recently, a series of reports revealed how Polycomb-mediated repression might buffer the precocious expression of somatic lineage regulators in ES cells. Notably, these genes carry bivalent chromatin enriched in both repressive (H3K27me3) and permissive (H3K4me2) histone marks. They are targeted by the Polycomb repressive complexes PRC1 (Ring1B) and PRC2, which mediates H3K27me3 and assemble poised RNA polymerase II (RNAP II), conferring silencing of loci primed for future activation (or repression) upon ES cell differentiation. During early development the transition from morula to blastocyst is the starting point for lineage segregation into the inner cell mass (ICM) and trophectoderm (TE). ES cells are derived from the ICM and are pluripotent. By contrast, TE-derived trophoblast stem (TS) cells are multipotent and contribute solely to placenta formation in vivo. To address whether ES cells epigenetic features are unique attributes of pluripotent cells in the early embryo, we compared the epigenetic status of key developmental genes in blastocyst-derived stem cells and in vivo. We provide direct evidence that bivalent histone markings operate in vivo from the eight-cell up to the blastocyst stage.
    [Show full text]
  • EMBO Encounters Issue43.Pdf
    WINTER 2019/2020 ISSUE 43 Nine group leaders selected Meet the first EMBO Global Investigators PAGE 6 Accelerating scientific publishing EMBO publishing costs Review Commons Making our journals’ platform announced finances public PAGE 3 PAGES 10 – 11 Welcome, Young Investigators! Contract replaces stipend Marking ten years 27 group leaders join the programme EMBO Postdoctoral Fellowships EMBO Molecular Medicine receive an update celebrates anniversary PAGES 4 – 5 PAGE 7 PAGE 13 www.embo.org TABLE OF CONTENTS EMBO NEWS EMBO news Review Commons: accelerating publishing Page 3 EMBO Molecular Medicine turns ten © Marietta Schupp, EMBL Photolab Marietta Schupp, © Page 13 Editorial MBO was founded by scientists for Introducing 27 new Young Investigators scientists. This philosophy remains at Pages 4-5 Ethe heart of our organization until today. EMBO Members are vital in the running of our Meet the first EMBO Global programmes and activities: they screen appli- Accelerating scientific publishing 17 journals on board Investigators cations, interview candidates, decide on fund- Review Commons will manage the transfer of ing, and provide strategic direction. On pages EMBO and ASAPbio announced pre-journal portable review platform the manuscript, reviews, and responses to affili- Page 6 8-9 four members describe why they chose to ate journals. A consortium of seventeen journals New members meet in Heidelberg dedicate their time to an EMBO Committee across six publishers (see box) have joined the Fellowships: from stipends to contracts Pages 14 – 15 and what they took away from the experience. n December 2019, EMBO, in partnership with decide to submit their work to a journal, it will project by committing to use the Review Commons Page 7 When EMBO was created, the focus lay ASAPbio, launched Review Commons, a multi- allow editors to make efficient editorial decisions referee reports for their independent editorial deci- specifically on fostering cross-border inter- Ipublisher partnership which aims to stream- based on existing referee comments.
    [Show full text]
  • 68690 Kings Parade Summer03
    KING’S Summer 2003 P ARADE Contents Interview: Judith Mayhew 2 Editor’s letter 3 The Masters in the 21st century 3 Parade Profile: Anne McLaren 4–5 Change of direction 6 Science at King’s 7 Books by members 8–9 What is art? 10–11 New Admissions Tutor for Access and Recruitment 12–13 Foundation Lunch 14–16 Praeposita John Barber: New Development Director 17 Here and now 18–19 nova King’s treasures at V&A 19 Events & Crossword 20 “King’s is delighted to announce the Chairman of the Policy & Resources The election was virtually unanimous, election of Dame Judith Mayhew, DBE, Committee of the Corporation of and unanimity is rare in King’s. Dame as Provost. She will take up office on 1 London. Her appointment as Judith will bring wide experience and October 2003. Dame Judith will Chairman of the Royal Opera House personal charm.’ Dame Judith said: ‘It succeed Professor Patrick Bateson, was announced in February. She is is a great honour and privilege to be who will retire after 15 years as Provost. currently Chairman of the Governors elected Provost of King’s, which has a Dame Judith is the first woman to be of Birkbeck College and a Trustee of long tradition of academic excellence elected Provost, and the first non- the Natural History Museum. The in learning and research combined Kingsman for centuries. She is a Vice-Provost, Professor Keith Hopkins, with its outstanding music.’” lawyer and has until recently been said: ‘We are all absolutely delighted. Press Release, 21 February, 2003.
    [Show full text]
  • Dr. Janet Rossant ANDREW F. HOLMES DEAN of MEDICINE DISTINCTION LECTURES
    Dr. Janet Rossant ANDREW F. HOLMES DEAN OF MEDICINE DISTINCTION LECTURES Dr. Janet Rossant, PhD, FRS, FRSC Chief of Research, SickKids Senior Scientist, Developmental & Stem Cell Biology, SickKids Lombard Insurance Chair in Pediatric Research University Professor, Department of Molecular Genetics, Obstetrics and Gynecology, University of Toronto Title Stem cells and early lineage development When Friday, October 18, 2013 11:30 a.m. – 1:00 p.m. Where CP Leblond Amphitheatre Strathcona Anatomy and Dentistry Building 3640 rue University Montreal, QC H3G 1Y6 Dr. Janet Rossant, SickKids Chief of Research and a world-renowned expert in developmental biology, is the definition of a trailblazer. Widely known for her studies of the genes that control embryonic development in the mouse, Dr. Rossant has pioneered techniques for following cell fate and altering genes in embryos. This work continues to resonate in medical genetic research. Her current research focuses on stem cell development and cell differentiation in the developing embryo, important areas for the study of birth defects as well as regenerative medicine. Firmly planted on the front lines of technological change, Dr. Rossant has established SickKids as a global forerunner in genetic research. Janet Rossant was born in Chatham, UK, and trained at the Universities of Oxford and Cambridge, United Kingdom. In 1977, Dr. Rossant moved to Canada and joined the faculty at Brock University. From 1985 to 2005, she was a leading researcher at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto. She joined SickKids in 2005 and became Chief of Research of the Research Institute. She is also a University Professor at the University of Toronto.
    [Show full text]
  • Schuler Dissertation Final Document
    COUNSEL, POLITICAL RHETORIC, AND THE CHRONICLE HISTORY PLAY: REPRESENTING COUNCILIAR RULE, 1588-1603 DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in the Graduate School of The Ohio State University By Anne-Marie E. Schuler, B.M., M.A. Graduate Program in English The Ohio State University 2011 Dissertation Committee: Professor Richard Dutton, Advisor Professor Luke Wilson Professor Alan B. Farmer Professor Jennifer Higginbotham Copyright by Anne-Marie E. Schuler 2011 ABSTRACT This dissertation advances an account of how the genre of the chronicle history play enacts conciliar rule, by reflecting Renaissance models of counsel that predominated in Tudor political theory. As the texts of Renaissance political theorists and pamphleteers demonstrate, writers did not believe that kings and queens ruled by themselves, but that counsel was required to ensure that the monarch ruled virtuously and kept ties to the actual conditions of the people. Yet, within these writings, counsel was not a singular concept, and the work of historians such as John Guy, Patrick Collinson, and Ann McLaren shows that “counsel” referred to numerous paradigms and traditions. These theories of counsel were influenced by a variety of intellectual movements including humanist-classical formulations of monarchy, constitutionalism, and constructions of a “mixed monarchy” or a corporate body politic. Because the rhetoric of counsel was embedded in the language that men and women used to discuss politics, I argue that the plays perform a kind of cultural work, usually reserved for literature, that reflects, heightens, and critiques political life and the issues surrounding conceptions of conciliar rule.
    [Show full text]
  • Web Conference with Dr. Janet Rossant
    Web Conference with Dr. Janet Rossant - 00:00 Thank you for taking the time to speak with us, so obviously we'd like to ask you some questions about your work and your research, but can you tell us about yourself and your research, how you got into stem cells in the first place? - 00:16 Okay, so I've been interested in early development for a very long time, sort of all my research career. I started as a graduate student at the University of Cambridge with Richard Gardner who was one of the first people who developed techniques to inject cells into blastocysts to make chimeras, and so I was always interested in how an egg develops into a complex organism, and over the years I've worked on the cell lineage in the early embryo. We've then been able to move in and identify some of the genes and pathways that specifies cell fate in the early embryo, and of course along the way, stem cells come into the picture because it's from the early mammalian embryo, the blastocysts, that you can derive embryonic stem cells, and it's really the work that I and my colleagues did early on in the embryo showing that there was a subset of cells that were pluripotent that gave people the idea that maybe you could capture that pluripotency and derive permanent cell lines from those cells and grow them in cultures. So we've worked on mouse embryonic stem cells, but we also have been able to show that we can derive stem cells from the other two types of the blastocysts, the trophoblast and the primitive endoderm, so in the mouse you can have three stem cell lines from the blastocysts, each of which replicates the properties of those lineages in vivo.
    [Show full text]
  • Anne Mclaren 1927–2007
    OBITUARY Anne McLaren 1927–2007 Courtesy of Gurdon Institute Gurdon of Courtesy Paul Burgoyne Anne McLaren died in a car accident along with her former husband Gurdon Institute website (http://www.gurdon.cam.ac.uk/anne-mclaren. and lifelong friend Donald Michie while traveling from Cambridge to html). Anne was of aristocratic stock (her father, Sir Henry McLaren, was London on 7 July 2007. While she made major contributions to studies of 2nd Baron Aberconway), and, at the MDU, I was once astounded to see mouse genetics and development, her immense strength was in distilling a letter addressed to “The Honorable Anne Laura Dorinthea McLaren.” scientific information and communicating it to others, and she worked Anne eschewed titles, and almost anyone who has met her will invari- tirelessly to ensure that sound scientific reasoning informed public policy ably refer to her as Anne rather than Doctor, Professor or Dame (as making. she became in 1993). Anne also had her own highly developed sense of After receiving her D.Phil. at Oxford in 1952, she worked together with social justice and responsibility, to which her whole life is a testimony. Michie in London at University College and then at The Royal Veterinary She joined the Communist Party, and this led to her being denied a visa College, where they became interested in the issue of nature versus nurture to the United States until around 1991—16 years after she had become in determining phenotypic characteristics. Their work, together with that a Fellow of the Royal Society! Anne was an inveterate traveler, heading of their subsequent colleague John Biggers, undermined the prevalent off to meetings in all parts of the globe with only a small rucksack and http://www.nature.com/naturegenetics assumption that the genetic uniformity of inbred mice led to phenotypic a plastic bag of papers to read on the plane.
    [Show full text]
  • Pnas11052ackreviewers 5098..5136
    Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H.
    [Show full text]