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Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies

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Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies Oxidative Medicine and Cellular Longevity Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies Guest Editors: Wei Chen, Zhenquan Jia, Min-Hsiung Pan, and Pon Velayutham Anandh Babu Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies Oxidative Medicine and Cellular Longevity Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies Guest Editors: Wei Chen, Zhenquan Jia, Min-Hsiung Pan, and Pon Velayutham Anandh Babu Copyright © 2016 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Oxidative Medicine and Cellular Longevity.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Mohammad Abdollahi, Iran Daniela Giustarini, Italy Valentina Pallottini, Italy Antonio Ayala, Spain Saeid Golbidi, Canada David Pattison, Australia Neelam Azad, USA Tilman Grune, Germany Serafina Perrone, Italy Peter Backx, Canada Hunjoo Ha, Republic of Korea Tiziana Persichini, Italy Damian Bailey, UK Guido Haenen, Netherlands Vincent Pialoux, France Consuelo Borrás, Spain Nikolas Hodges, UK Chiara Poggi, Italy Vittorio Calabrese, Italy Tim Hofer, Norway Aurel Popa-Wagner, Germany Angel Catalá, Argentina Silvana Hrelia, Italy Ada Popolo, Italy Shao-Yu Chen, USA Vladimir Jakovljevic, Serbia José L. Quiles, Spain Zhao Zhong Chong, USA Peeter Karihtala, Finland Kota V. Ramana, USA Giuseppe Cirillo, Italy Raouf A. Khalil, USA Pranela Rameshwar, USA Massimo Collino, Italy Kum Kum Khanna, Australia Sidhartha D. Ray, USA Mark J. Crabtree, UK Neelam Khaper, Canada Alessandra Ricelli, Italy Manuela Curcio, Italy Thomas Kietzmann, Finland Francisco J. Romero, Spain Andreas Daiber, Germany Mike Kingsley, UK Vasantha Rupasinghe, Canada Felipe Dal Pizzol, Brazil Ron Kohen, Israel Gabriele Saretzki, UK Francesca Danesi, Italy W. J.H. Koopman, Netherlands Honglian Shi, USA Domenico D’Arca, Italy Jean-Claude Lavoie, Canada Cinzia Signorini, Italy Yolanda de Pablo, Sweden Christopher Horst Lillig, Germany Dinender K. Singla, USA James Duce, UK Paloma B. Liton, USA Richard Siow, UK Grégory Durand, France Nageswara Madamanchi, USA Shane Thomas, Australia Javier Egea, Spain Kenneth Maiese, USA Rosa Tundis, Italy Amina El Jamali, USA Tullia Maraldi, Italy Giuseppe Valacchi, Italy Ersin Fadillioglu, Turkey Reiko Matsui, USA Jeannette Vasquez-Vivar, USA Qingping Feng, Canada Steven McAnulty, USA Victor M. Victor, Spain Giuseppe Filomeni, Italy Bruno Meloni, Australia Michal Wozniak, Poland Swaran J. S. Flora, India Trevor A. Mori, Australia Sho-ichi Yamagishi, Japan Rodrigo Franco, USA Ryuichi Morishita, Japan Liang-Jun Yan, USA José Luís García-Giménez, Spain Ange Mouithys-Mickalad, Belgium Guillermo Zalba, Spain Janusz Gebicki, Australia Noriko Noguchi, Japan Jacek Zielonka, USA Husam Ghanim, USA Hassan Obied, Australia Matthew C. Zimmerman, USA Laura Giamperi, Italy Pál Pacher, USA Contents Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies Wei Chen, Zhenquan Jia, Min-Hsiung Pan, and Pon Velayutham Anandh Babu Volume 2016, Article ID 4628502, 2 pages A Potential Alternative against Neurodegenerative Diseases: Phytodrugs Jesús Pérez-Hernández, Víctor Javier Zaldívar-Machorro, David Villanueva-Porras, Elisa Vega-Ávila, and Anahí Chavarría Volume 2016, Article ID 8378613, 19 pages Role of Natural Stilbenes in the Prevention of Cancer J. Antoni Sirerol, María L. Rodríguez, Salvador Mena, Miguel A. Asensi, José M. Estrela, and Angel L. Ortega Volume 2016, Article ID 3128951, 15 pages Wild Raspberry Subjected to Simulated Gastrointestinal Digestion Improves the Protective Capacity against Ethyl Carbamate-Induced Oxidative Damage in Caco-2 Cells Wei Chen, Yang Xu, Lingxia Zhang, Ya Li, and Xiaodong Zheng Volume 2016, Article ID 3297363, 12 pages Low-Dose Aronia melanocarpa Concentrate Attenuates Paraquat-Induced Neurotoxicity A.J.Case,D.Agraz,I.M.Ahmad,andM.C.Zimmerman Volume 2016, Article ID 5296271, 11 pages Reviews on Mechanisms of In Vitro Antioxidant Activity of Polysaccharides Junqiao Wang, Shuzhen Hu, Shaoping Nie, Qiang Yu, and Mingyong Xie Volume 2016, Article ID 5692852, 13 pages Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation Yang Bai, Xiaolu Wang, Song Zhao, Chunye Ma, Jiuwei Cui, and Yang Zheng Volume2015,ArticleID407580,13pages Biomolecular Modulation of Neurodegenerative Events during Ageing Marcella Nebbioso, Gianfranco Scarsella, Aloisa Librando, and Nicola Pescosolido Volume2015,ArticleID978654,10pages Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells Hongming Lv, Hua Ren, Lidong Wang, Wei Chen, and Xinxin Ci Volume 2015, Article ID 709845, 13 pages Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2016, Article ID 4628502, 2 pages http://dx.doi.org/10.1155/2016/4628502 Editorial Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies Wei Chen,1 Zhenquan Jia,2 Min-Hsiung Pan,3 and Pon Velayutham Anandh Babu4 1 Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China 2Department of Biology, The University of North Carolina at Greensboro, Greensboro, NC 27412, USA 3Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan 4Division of Nutrition, College of Health, University of Utah, Salt Lake City, UT 84112, USA Correspondence should be addressed to Wei Chen; [email protected] Received 26 November 2015; Accepted 26 November 2015 Copyright © 2016 Wei Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Current opinions with respect to the etiology of chronic highlight the role of some of the natural products that ame- diseases such as neurodegenerative disease, cardiovascular liorate oxidative stress and reduce pathological complications diseases, and cancer are still controversial. There are multiple associated with chronic diseases. The articles published in this factors involved, and oxidative stress that results from the special issue include four reviews and four original research imbalance between reactive oxygen species and antioxidants articles that describe the importance of some of the natural is a one of the key factors in the development of these products. chronic diseases. Indeed, experimental and clinical evidences The review by J. Perez-Hern´ andez´ et al. is focused on the support the casual relationship between oxidative stress and possible role of antioxidant herbal compounds as an alterna- various chronic diseases. Thus, numerous studies are focused tive source for the treatment of neurodegenerative diseases on ameliorating these chronic diseases by reducing the (ND).Theherbalcompoundsdiscussedinthisreviewinclude oxidative stress. Epidemiological and clinical studies suggest polyphenols, flavonoids, alkaloids, and other miscellaneous that natural products can combat oxidative stress and reduce antioxidant compounds from plants. An interesting review the morbidity and mortality associated with chronic diseases. article by Y. Bai et al. discusses the cardiovascular bene- Many natural compounds such as flavonoids are potential ficial effects of sulforaphane, a sulfur-based isothiocyanate antioxidants that protect against reactive oxygen species compound in the cruciferous vegetables. Clinical and ani- (ROS) or reactive nitrogen species- (RNS-) induced damage mal studies showed sulforaphane improved cardiovascular and ameliorate oxidative stress-related diseases, such as complications through activation of Nrf2. In this review, the neurodegenerative diseases, cardiovascular diseases, inflam- authors discuss the possible molecular mechanisms involved matory conditions, and cancer. Although various natural in sulforaphane induced Nrf2 activation. J. A. Sirerol et al.’s productshavebeenshowntopossesspotentialprotective reviewisfocusedontheroleofnaturalcompoundstilbene effects against chronic diseases, the bioactivities of large in the prevention of cancer. The authors discuss about the number of natural compounds remain unknown. Therefore, studies that support the anticancer effects of stilbene, which understanding and validating the bioactivities of the natural also include few clinical trials. In this issue, the review article compounds and the molecular mechanisms involved would by J. Wang et al. discusses the latest advancements and up- provide solid scientific foundation to use the natural com- to-date discoveries on the mechanisms of antioxidant activity pounds for the prevention and treatment of oxidative stress- of polysaccharides and glycoconjugates derived from natural related diseases. The primary objective of this issue is to products. 2 Oxidative Medicine and Cellular Longevity ROSplayamajorroleintheagingprocessandsignifi- cantly contribute to the aging related pathological complica- tions. The antioxidant system is compromised with aging and the antioxidant levels are no longer sufficient to counteract the generation of free radicals. Exogenous antioxidants
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